TWAS
hub
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Models
Genes
Traits
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Traits
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Bipolar Disorder or Schizophrenia
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chr2:233,227,833-234,123,010
Best TWAS P=2.34e-10 · Best GWAS P=1.77e-11 conditioned to 1
233.2M
233.4M
233.6M
233.8M
234M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
The Cancer Genome Atlas
Colon Adenocarcinoma
NGEF
0.14
0.03
lasso
4
0.03
6.2e-03
6.7
6.3
2.3e-10
0.98
0.00
0.94
TRUE
2
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
EFHD1
0.11
0.01
blup
70
0.03
1.0e-02
6.2
5.5
4.8e-08
0.37
0.01
0.88
TRUE
5
The Cancer Genome Atlas
Thyroid Carcinoma
NGEF
0.04
0.03
enet
7
0.03
5.6e-04
6.0
-5.5
2.8e-08
-0.42
0.15
0.73
FALSE
3
The Cancer Genome Atlas
Skin Cutaneous Melanoma
NGEF
0.28
0.11
enet
11
0.18
1.1e-05
6.7
5.5
4.1e-08
0.85
0.00
0.96
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
KCNJ13
0.03
0.00
blup
35
0.01
4.3e-02
6.1
-5.3
1.1e-07
-0.43
0.01
0.66
FALSE