Hub : Genes

EFHD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0440	0.0200	5.3e-03	0.006	0.021	0.004	0.022	0.002	4.9e-02	1.1e-03	9.4e-02	9.0e-04	1.7e-01
2	GTEx	Breast Mammary Tissue (Female)	0.0815	0.0839	2.0e-01	0.089	NA	0.047	NA	0.077	1.3e-03	NA	1.6e-02	NA	2.6e-03
3	GTEx	Liver	0.2970	0.1060	6.0e-03	0.189	NA	0.113	NA	0.100	5.8e-06	NA	4.8e-04	NA	1.0e-03
4	GTEx	Muscle Skeletal	0.0821	0.0335	4.4e-03	-0.001	NA	0.002	NA	-0.002	4.0e-01	NA	1.8e-01	NA	5.6e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.1650	0.0482	1.2e-05	0.052	0.035	0.056	0.083	0.044	2.8e-07	2.1e-05	8.7e-08	8.8e-11	1.9e-06
6	YFS	Blood	0.0718	0.0240	1.6e-06	0.000	0.025	0.030	0.027	0.008	5.2e-01	8.9e-09	4.2e-10	3.2e-09	1.0e-03
7	TCGA	Breast Invasive Carcinoma	0.0646	0.0231	2.2e-10	0.058	0.064	0.055	NA	0.061	5.4e-12	5.4e-13	1.7e-11	NA	2.0e-12
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1140	0.0580	5.3e-03	0.011	0.027	0.022	NA	0.018	7.7e-02	1.0e-02	1.8e-02	NA	3.1e-02
9	TCGA	Brain Lower Grade Glioma	0.0466	0.0293	3.1e-03	0.009	0.011	0.009	NA	0.007	2.8e-02	1.7e-02	3.0e-02	NA	4.7e-02
10	TCGA	Liver Hepatocellular Carcinoma	0.2960	0.1000	6.2e-04	0.037	0.088	0.095	NA	0.061	7.7e-03	5.9e-05	3.1e-05	NA	8.0e-04
11	TCGA	Prostate Adenocarcinoma	0.2357	0.0593	8.5e-12	0.151	0.118	0.148	NA	0.141	1.5e-15	2.7e-12	3.0e-15	NA	1.4e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.9	1.5	8.4	1.4	-0.8	-1.1	0.7	-0.6	0.0	-0.5	2.9	-0.6	-1.1	-1.3
Bipolar Disorder or Schizophrenia	1.9	4.7	29.8	1.1	-1.4	-1.9	-0.3	-0.5	1.0	-1.4	5.5	-1.8	-2.1	-2.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	1.0	-0.6	-0.9	-0.8	0.7	0.5	-1.2	0.4	0.1	-0.8	-0.6
Depression (Nagel 2018)	0.4	0.7	1.5	-1.0	-0.2	-0.7	-1.2	-0.3	1.2	-0.4	-0.9	-1.1	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.8	2.4	11.4	2.6	0.4	0.2	2.4	0.9	0.1	0.3	3.4	0.4	-0.9	0.1
Neuroticism (Nagel 2018)	0.4	1.1	4.7	2.2	-0.6	-0.7	-0.3	1.8	0.8	-1.0	0.2	0.2	-0.6	-0.6
Schizophrenia (2018)	1.7	3.5	22.0	0.2	-1.1	-1.6	-1.0	-0.1	1.5	-1.3	4.7	-1.8	-1.7	-1.5
Schizophrenia vs Biploar Disorder	0.7	0.9	2.1	-0.6	-0.6	-1.1	-1.2	-0.6	1.4	-0.8	1.0	-1.3	-0.6	-0.9
Worry (Nagel 2018)	0.4	0.8	4.2	2.1	0.4	0.1	0.0	1.7	1.1	-0.2	0.3	0.3	-0.2	0.1
Alzheimer’s Disease (in mother)	0.4	0.5	2.9	1.0	0.0	0.4	0.3	0.2	-1.7	0.2	0.1	0.3	-0.9	0.1
Alzheimer’s Disease (in father)	0.6	0.6	2.3	-0.0	0.7	0.5	0.9	-0.2	-0.2	1.0	-0.6	1.0	1.5	0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.1	0.3	0.1	0.7	0.8	1.0	-1.4	0.9	-1.4	1.0	0.5	0.5
Crohns Disease (2017)	0.5	1.1	3.1	0.1	-1.1	-1.2	-1.0	-1.1	0.6	-1.8	-0.1	-1.6	-0.1	-1.2
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	0.5	-0.3	-0.5	0.5	-0.4	0.2	-1.1	-1.0	-1.5	0.5	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.8	0.5	0.1	0.0	1.3	0.6	0.2	-0.3	-1.2	-0.6	0.3	-0.1
Major Depression (MDD)	0.4	0.5	1.8	-1.3	-0.2	-0.3	-1.0	0.5	0.9	-0.3	-0.6	-0.6	0.4	-0.3
Reaction Time	0.8	1.5	3.2	-0.9	-1.8	-1.1	-0.1	0.8	-0.2	-1.1	1.5	-1.8	-0.6	-1.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	3.0	0.2	0.1	-0.5	-0.5	-0.8	0.0	-0.3	1.7	-0.8	-1.2	-0.5
Breast Cancer	2.2	5.4	15.1	0.1	-3.9	-3.4	-1.5	-0.7	0.0	-3.4	0.5	-1.3	-1.8	-3.6
Ovarian Cancer	1.2	1.5	8.3	0.8	0.2	1.1	1.7	2.9	-0.9	1.2	-0.1	1.0	0.5	0.5
Prostate Cancer	3.9	5.5	11.6	0.1	-3.4	-3.0	-1.8	-0.3	0.2	-2.8	2.3	-1.7	-3.2	-3.4
Age at First Birth	0.7	1.1	3.2	1.8	0.3	1.1	1.7	1.3	-0.9	0.2	1.0	-0.4	0.2	0.7
Bipolar Disorder (2011)	1.6	1.5	3.9	1.3	-1.1	-1.0	0.5	0.7	-0.2	-1.0	2.0	-1.8	-1.5	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	1.2	0.9	1.2	1.6	1.2	-0.8	0.9	0.5	1.5	0.0	0.6
Coronary Artery Disease (CAD)	1.0	1.2	5.3	-2.3	-0.0	1.0	0.2	-0.2	-0.3	1.1	-1.1	0.6	1.7	0.9
Crohns Disease (2012)	0.3	0.4	1.6	-0.4	-0.3	-0.6	0.1	0.1	1.3	-0.6	-0.3	-0.9	-0.6	-0.9
Mean Putamen Volume	1.7	1.9	4.0	-0.6	1.9	1.5	1.3	0.0	0.6	2.0	-0.3	1.4	1.6	1.9
Fasting Glucose	0.4	0.5	2.7	-0.0	0.4	1.1	1.6	-0.4	-0.6	0.2	-0.7	-0.1	-0.3	0.4
HbA1C	3.7	4.1	11.1	-0.5	-3.3	-2.8	-0.5	1.5	-1.0	-2.7	-1.2	-1.3	-1.5	-3.2
HDL Cholesterol	0.5	0.8	3.0	-0.4	-0.1	-0.2	-0.3	-0.8	-1.7	-0.5	1.7	-1.0	-0.4	-0.3
LDL Cholesterol	0.4	0.6	2.5	1.6	-0.8	-0.4	0.5	0.2	-1.0	-0.6	1.1	0.2	0.2	-0.4
Lupus	1.0	1.4	5.1	1.9	0.5	0.6	0.4	0.7	-0.6	0.4	2.3	1.4	-1.9	0.0
Neuroticism (2016)	0.4	0.5	1.1	0.8	1.1	0.9	0.0	0.6	-0.7	0.6	-0.9	0.5	-0.6	0.8
Primary Biliary Cirrhosis	0.4	0.5	2.2	-0.4	-0.5	-0.5	-1.5	-0.6	-0.1	-0.5	-1.2	0.4	-0.7	-0.5
Rheumatoid Arthritis	0.7	1.0	2.3	-0.6	1.1	1.1	-1.1	0.6	0.1	0.5	-1.5	1.1	1.1	1.1
Schizophrenia (2014)	2.3	5.1	38.2	1.3	-1.1	-1.5	-0.3	-0.1	0.7	-1.4	6.2	-2.1	-1.6	-1.7
Triglycerides	1.4	2.3	5.3	0.8	-2.3	-2.0	-1.6	0.3	-0.7	-2.1	0.1	-1.3	-1.0	-2.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	-0.7	-1.4	-0.9	0.4	1.2	0.3	-0.7	-1.1	-0.1	-1.4	-1.1
Ulcerative Colitis	0.8	1.2	4.1	0.6	1.4	0.9	2.0	0.4	1.1	0.9	-1.5	0.2	0.7	0.9
Blood Eosinophil Count	0.2	1.8	6.2	2.1	-0.9	-0.5	-0.1	0.6	0.0	-0.5	2.5	0.1	-2.4	-1.0
Blood Platelet Count	0.9	10.8	31.0	-3.5	-4.2	-4.3	-5.6	-2.0	1.3	-3.2	-0.1	-1.8	-2.7	-3.7
Blood Red Count	0.1	1.0	5.0	2.2	0.8	0.7	1.1	0.3	-1.1	-0.1	0.5	-0.9	1.0	0.7
Blood White Count	0.6	4.5	12.7	0.0	-2.2	-2.4	-1.9	-2.0	0.8	-1.6	3.6	-1.0	-3.0	-2.3
Heel T-Score	0.2	1.4	3.7	-1.3	1.1	0.9	1.3	-1.9	-0.7	1.2	0.3	0.8	1.3	1.1
BMI	0.3	1.7	9.2	1.0	0.8	-0.0	-0.2	-3.0	-1.4	0.4	2.1	-0.5	0.9	0.5
Height	1.9	36.2	169.0	3.4	-5.0	-4.7	0.9	6.9	5.6	-2.0	13.0	-2.1	-7.7	-4.8
Waist Hip Ratio (WHR)	0.6	2.6	8.9	-2.3	0.6	1.7	-0.2	3.0	-0.7	1.2	-2.7	0.1	1.1	1.0
Systolic Blood Pressure	0.1	0.6	2.2	-1.5	0.4	0.6	-0.8	-0.4	0.6	0.2	0.3	-0.6	1.3	0.9
Smoking Status	1.4	3.4	15.4	2.4	-0.3	0.9	3.9	2.4	-1.0	0.4	0.1	2.1	-1.8	-0.4
Allergy or Eczema	0.4	1.0	3.4	-0.9	-0.7	-0.8	-1.8	-1.8	0.4	-1.1	-0.2	-0.8	0.0	-0.7
Cardiovascular Disease	0.2	0.5	1.4	-0.3	0.7	0.8	0.4	-0.3	-0.4	0.9	0.7	0.5	1.2	0.9
Hypothyroidism (self reported)	0.1	0.3	0.6	0.6	-0.8	-0.4	0.5	-0.0	0.6	-0.7	0.5	-0.6	0.5	-0.1
Respiratory disease	0.5	1.2	2.7	0.4	1.5	1.3	0.5	-0.3	-1.0	1.5	0.4	1.3	-1.6	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.7	2.3	-1.3	0.3	0.8	0.2	0.3	-0.3	1.0	-0.6	0.6	1.5	0.7
Lung FEV1/FVC ratio	0.5	2.5	5.7	0.7	1.2	1.7	0.3	2.4	0.8	2.4	-0.1	2.2	1.4	1.9
Lung FVC	1.0	5.1	19.4	-0.0	2.1	2.0	2.9	-1.7	-1.1	1.1	-4.4	2.0	2.4	2.1
Neuroticism	0.5	1.3	4.6	2.1	-1.1	-1.1	0.3	1.8	0.4	-1.5	0.2	-0.0	-0.6	-1.1
Chronotype (morning person)	0.7	1.7	6.9	-2.6	0.5	-0.3	-2.0	-1.1	1.1	-0.3	-2.2	-0.3	0.5	0.4
Hair Pigment	0.3	7.6	26.5	1.4	-2.1	-2.6	-2.6	-1.2	0.5	-3.3	5.2	-4.2	-1.3	-2.2
Tanning	0.4	5.0	9.9	-0.1	2.6	2.9	1.6	2.2	0.4	2.8	-3.1	2.5	1.2	2.7
Hand grip strength (left)	1.1	2.9	9.2	2.8	0.2	0.5	3.0	2.2	-1.3	0.7	1.0	1.9	-1.6	0.3
Number of treatments/medications taken	0.6	1.0	5.7	1.0	-0.4	-0.9	-0.5	-2.4	0.4	-0.7	1.4	-0.1	0.6	-0.3
Average weekly spirits intake	1.7	2.1	7.2	2.0	0.3	0.6	1.9	2.1	-0.2	1.3	0.5	2.7	-1.4	0.1
Sensitivity / hurt feelings	0.7	1.2	6.3	0.9	-0.8	-0.5	0.0	2.0	2.5	-0.4	0.3	-0.3	1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.2	-2.1	-0.5	-0.5	-1.9	0.5	1.2	-0.2	-0.1	-0.6	-0.4	-0.4
Hearing difficulty/problems: Yes	0.8	1.2	6.3	2.3	-0.2	-0.1	0.9	0.5	0.1	-0.7	2.5	-0.1	-0.4	-0.3
Relative age of first facial hair	3.1	6.3	17.5	-3.1	-1.7	-1.9	-4.2	-2.0	1.9	-1.7	2.5	-3.6	-1.6	-1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	0.4	0.4	0.2	0.0	-0.3	-0.4	0.5	1.2	0.4	-0.9	0.3
Ever used hormone-replacement therapy (HRT)	1.9	2.5	5.4	0.9	2.2	2.1	1.1	0.1	0.3	1.8	-1.3	0.5	2.3	2.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.9	0.2	0.7	-0.1	0.5	-0.7	-0.2	1.2	0.3	1.0	-1.4	0.2
Systolic blood pressure, automated reading	0.2	0.7	2.4	-0.1	0.8	1.0	0.1	-1.1	0.0	0.0	0.1	-1.1	1.5	1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	-0.3	-1.0	-1.5	-0.8	-0.7	1.2	-1.2	0.8	0.1	-1.4	-1.2
Angina	1.1	1.5	4.4	0.0	0.8	0.9	1.0	-0.2	-1.4	1.7	-1.8	2.1	0.8	0.9
Medication for hormone replacement therapy	0.4	0.4	1.3	-0.0	-0.2	0.2	-0.2	1.1	1.1	-0.3	-0.7	-0.7	0.8	-0.1
Vitamin and mineral supplements	0.3	0.4	1.0	-0.7	0.4	0.7	-1.0	0.4	0.4	-0.2	-0.8	-0.7	0.2	0.4
Supplements: Zinc	0.5	0.5	1.2	1.1	-0.8	-0.8	0.9	0.3	-0.9	-0.8	0.8	0.1	0.1	-0.8
Medication: Co-codamol	0.3	0.3	1.2	0.4	0.7	0.7	0.4	-0.6	-0.3	1.1	0.4	-0.5	0.4	0.4
Medication: Metformin	0.4	0.6	1.4	-0.7	-1.0	-1.2	-0.5	-1.1	-0.2	-0.1	-0.3	0.4	-1.1	-1.0
Diabetes (father)	4.8	5.9	16.2	-1.8	-2.8	-2.6	-4.0	0.5	0.9	-3.2	-0.1	-3.1	-1.6	-2.8
Diabetes (mother)	0.3	0.4	1.8	-1.0	0.0	0.2	-1.3	-0.8	0.3	0.2	-0.7	-0.6	0.3	0.3
Severe depression (siblings)	0.6	0.7	1.9	-0.4	-0.5	-0.7	-1.0	-1.1	0.2	-0.8	1.4	-1.0	-0.4	-0.5
Pack years adult smoking proportion	0.5	0.7	5.1	-2.3	0.3	0.7	-0.8	0.4	0.3	0.7	0.1	-0.2	0.6	0.3
Impedance of leg (right)	0.8	4.1	11.2	-3.4	-2.1	-1.4	-1.8	1.8	2.6	-1.4	-2.7	-1.1	-0.8	-1.7
Leg fat-free mass (left)	1.3	6.9	49.7	2.1	-1.3	-2.2	-0.2	-0.2	1.0	-0.3	7.0	-0.2	-3.4	-1.7
Trunk fat percentage	0.4	1.7	4.6	-1.2	-0.4	-1.5	-1.7	-1.9	1.1	0.6	2.1	-0.2	-0.9	-0.8
Hand grip strength (right)	1.6	4.2	14.1	3.8	0.5	0.9	3.4	2.0	-1.3	0.9	1.9	2.5	-1.8	0.7
Townsend deprivation index at recruitment	1.3	1.9	11.8	-3.4	0.0	0.7	-1.7	1.0	-1.3	0.3	-1.6	-0.3	0.5	-0.1
Current tobacco smoking	0.7	1.2	3.3	0.8	-0.1	0.6	1.8	1.4	-0.9	0.6	-0.7	1.8	-1.2	-0.0
Average weekly fortified wine intake	1.4	1.7	5.9	1.4	-0.2	-1.1	-0.9	-1.9	0.1	-0.6	2.4	-1.3	-1.4	-0.7
Maternal smoking around birth	0.9	1.3	5.7	1.2	0.8	0.2	2.4	-0.5	-1.8	0.8	-0.9	1.1	-0.5	0.3
Fed-up feelings	0.2	0.4	2.1	0.8	-0.5	-0.3	0.4	1.4	0.2	-0.6	-0.6	-0.2	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	4.6	-2.1	-0.1	-0.3	-1.6	-0.4	0.8	0.2	-0.1	-0.8	0.1	-0.1
Relative age voice broke	2.2	3.4	10.4	-2.0	0.0	-0.2	-3.1	-1.9	2.2	-0.5	1.8	-3.2	0.9	0.3
Taking other prescription medications	0.4	0.6	2.9	1.7	-0.1	-0.5	0.2	-1.3	0.4	-0.6	0.7	-0.0	-0.5	-0.4
Age when periods started (menarche)	0.1	0.2	1.2	0.5	-0.3	0.6	0.5	1.1	-0.2	0.2	-0.4	-0.5	0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	-1.0	0.7	0.6	0.6	-0.4	-0.6	0.9	-1.2	1.2	-1.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	9.9	1.3	0.2	-0.0	3.1	-0.2	-1.3	1.0	0.1	1.9	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.4	-0.0	1.5	1.4	1.4	0.5	0.1	1.2	-0.5	1.3	1.0	1.5
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.8	-0.3	-0.6	-0.4	-0.1	0.5	0.2	-0.5	0.6	-0.7	-0.5
Serious illness, injury or assault to yourself	1.1	1.4	3.8	-0.0	1.9	1.6	1.0	-0.7	0.1	2.0	-0.4	0.5	0.7	1.7
High blood pressure	0.5	1.4	2.4	0.1	1.5	1.5	1.4	-0.6	-0.6	1.4	1.3	0.1	1.3	1.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.8	-0.5	-0.9	-0.6	-2.0	-1.1	0.6	-1.0	-0.0	-0.5	0.2	-0.8
Multivitamins +/- minerals	0.4	0.5	1.3	-0.3	-1.0	-1.1	0.3	-0.0	0.1	-0.4	-0.6	0.7	-0.6	-1.1
Stomach or abdominal pain in last month	0.4	0.5	3.4	-0.5	-0.6	-0.5	-1.8	-0.6	0.5	-0.5	0.7	-0.1	0.0	-0.7
Supplements: Glucosamine	0.8	1.0	3.8	-1.2	0.3	0.6	0.8	1.4	0.2	0.4	-1.2	0.1	1.9	0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.3	-0.0	1.0	0.9	-0.2	-1.3	-0.1	1.3	1.5	0.3	1.5	1.3
Medication: Atenolol	0.6	0.7	2.6	-0.4	0.6	0.9	0.5	0.9	0.6	0.7	-0.7	0.5	1.6	1.1
Medication: Levothyroxine sodium	0.4	0.7	2.9	-0.9	-0.8	-1.2	-0.8	-1.7	0.8	-0.6	0.3	-0.6	-0.4	-0.5
Sitting height	2.4	17.0	102.0	4.6	-2.7	-2.9	1.5	1.9	1.8	-2.0	10.1	-1.2	-5.1	-2.9
Chronic bronchitis/emphysema (father)	1.0	1.2	3.2	1.7	0.6	1.1	1.6	0.7	-0.7	1.0	0.1	1.8	0.1	0.7
High blood pressure (mother)	0.2	0.3	1.0	-0.0	0.5	0.5	0.7	0.6	-1.0	0.2	-0.8	0.1	-0.1	0.3
Body mass index (BMI)	0.4	1.8	12.7	-0.4	0.2	-0.9	-1.7	-3.6	-0.4	0.4	1.7	-0.5	0.1	-0.2
Impedance of leg (left)	0.6	3.1	8.9	-3.0	-1.5	-1.0	-1.1	2.1	2.5	-0.8	-2.7	-0.5	-0.2	-1.1
Leg predicted mass (left)	1.3	6.7	48.6	2.0	-1.3	-2.1	-0.2	-0.1	1.0	-0.2	7.0	-0.3	-3.3	-1.6
Trunk fat mass	0.7	3.0	17.6	-0.5	-0.7	-1.8	-1.6	-1.6	1.4	0.5	4.2	-0.5	-1.6	-1.1
Waist circumference	0.6	2.0	9.8	-0.0	-0.8	-1.5	-1.6	-1.9	0.3	-0.3	3.1	-1.2	-1.0	-1.0
Number of incorrect matches in round	0.3	0.6	1.6	-0.7	-0.6	-0.4	-0.2	0.4	-1.3	-0.7	-0.2	-1.2	1.2	-0.3
Past tobacco smoking	0.5	0.9	3.3	-1.0	0.4	-0.1	-1.8	-1.2	0.4	0.4	-1.4	-0.1	1.1	0.6
Alcohol usually taken with meals	1.4	2.3	7.9	2.5	-1.7	-1.4	0.7	1.0	-0.1	-1.4	2.8	-1.1	-0.1	-1.2
Nervous feelings	0.2	0.4	1.3	0.3	1.2	0.8	-0.2	-0.3	0.0	0.4	0.4	-0.4	0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	5.3	-2.3	0.3	-0.1	-1.8	-0.5	2.3	0.8	-1.0	0.5	-0.4	0.1
Hearing difficulty/problems with background noise	0.3	0.4	1.9	1.4	0.3	0.3	0.9	0.2	-0.5	-0.1	1.1	-0.1	-0.4	0.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.9	-0.9	-0.6	-0.3	0.4	0.0	-1.0	-1.3	-1.0	-1.4	0.8	-0.5
Had menopause	0.6	0.7	2.6	-1.2	0.4	0.7	-0.7	0.6	0.1	0.3	0.9	-1.6	1.1	0.6
Had other major operations	1.0	1.3	2.6	0.8	1.4	1.6	1.3	0.4	-1.2	1.4	0.8	-0.5	0.5	1.6
Forced vital capacity (FVC)	0.3	1.1	3.4	1.0	-0.8	-0.6	0.6	1.9	0.7	-0.5	1.0	1.6	-1.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	7.8	0.8	1.0	0.8	2.8	-1.0	-2.2	1.8	-0.0	2.3	0.4	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	5.6	0.8	0.4	-0.4	-0.1	-0.3	-0.2	0.5	2.4	0.9	-0.5	0.2
Qualifications: None of the above	0.6	1.3	4.5	-1.9	-0.2	-0.3	-1.2	-1.2	-0.9	-0.5	-2.1	-1.5	0.4	-0.3
Financial difficulties in last 2 years	0.5	0.6	1.9	-1.2	0.5	0.3	-1.2	-0.7	-0.5	0.4	-0.0	-1.4	0.6	0.6
Mouth/teeth dental problems	0.3	0.5	4.1	0.3	0.8	0.0	-0.0	-2.0	-0.6	-0.2	-0.3	-0.2	0.4	0.5
Heart attack	0.4	0.5	1.4	-0.8	0.8	0.2	-0.9	-1.2	-0.4	0.3	-0.6	-1.1	0.5	0.4
Allergy	0.3	0.6	3.3	0.7	-0.2	-0.0	1.6	1.8	-0.3	0.3	0.0	0.2	-0.1	-0.0
Pain all over the body in last month	0.3	0.4	1.1	-1.1	0.0	-0.1	-0.3	-0.5	0.9	-0.1	-0.9	-0.8	-0.4	-0.2
Diabetes (self-reported)	0.2	0.3	1.0	-0.2	-0.5	-0.5	-0.6	-0.9	-0.8	0.2	-0.1	1.0	0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.5	0.5	-0.1	0.2	-1.2	0.6	0.2	-0.3	-0.0	1.2	-0.3	-0.1
Medication: Ramipril	0.2	0.3	0.7	0.3	0.4	0.3	0.4	0.2	0.5	0.7	-0.8	0.8	0.8	0.4
Medication: Simvastatin	1.1	1.6	4.8	0.5	1.1	1.0	1.4	0.2	-2.1	1.6	0.5	2.2	-0.2	0.9
Fluid intelligence score	0.2	0.5	1.2	0.8	0.9	0.7	0.8	0.5	-0.6	0.7	-0.3	1.1	-0.2	0.5
Illnesses of siblings	0.8	1.1	7.7	-0.4	0.5	0.3	0.5	-0.3	1.1	1.1	-0.3	2.8	0.8	0.8
Neuroticism score	0.2	0.5	3.1	1.3	-0.2	-0.1	0.1	1.8	0.1	-0.5	0.1	-0.1	-0.1	-0.1
Weight	1.0	4.8	35.7	0.9	-1.0	-2.0	-1.1	-1.0	1.3	0.2	6.0	-0.6	-2.4	-1.3
Impedance of arm (right)	0.3	1.3	6.6	-1.9	-0.7	-0.2	-0.1	1.1	1.2	-0.4	-2.6	-0.3	0.4	-0.5
Arm fat percentage (right)	0.5	1.9	12.6	-1.9	0.3	-0.7	-1.7	-3.5	-0.1	0.7	0.2	-0.4	0.9	-0.1
Trunk fat-free mass	1.6	9.4	64.5	2.2	-2.0	-2.6	-0.4	0.9	2.1	-1.0	8.0	-0.7	-3.6	-2.0
Hip circumference	1.0	4.2	25.3	1.3	-1.1	-2.2	-1.0	-2.1	0.9	-0.3	5.0	-0.7	-2.0	-1.4
Time employed in main current job	0.9	1.0	3.0	-0.3	1.3	1.5	-0.0	-0.3	-0.6	1.4	0.1	0.4	1.3	1.7
Alcohol intake versus 10 years previously	0.8	1.2	2.7	-0.5	-1.4	-1.6	-1.1	0.4	-0.2	-0.8	-1.0	0.5	-1.5	-1.6
Father’s age at death	0.7	0.9	3.7	1.9	-0.4	0.1	0.8	0.7	-0.7	-0.5	1.9	0.2	-0.7	-0.0
Worrier / anxious feelings	0.5	1.0	7.5	1.5	0.6	0.6	0.3	2.7	-0.2	0.3	-0.5	0.4	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	9.7	-1.6	-1.1	-1.2	-3.1	-0.8	-0.1	-0.5	-0.4	-0.1	-0.7	-1.1
Falls in the last year	0.2	0.3	1.1	-0.8	-0.2	-0.4	-0.2	-0.1	0.4	-0.4	-0.5	-1.1	0.4	-0.5
Hair/balding pattern: Pattern 3	0.4	0.5	4.1	1.0	0.5	0.1	-0.3	0.3	-0.3	0.5	2.0	-0.1	0.1	0.1
Number of live births	0.3	0.5	2.3	0.4	1.1	-0.0	0.7	-1.5	0.5	0.4	-0.1	0.0	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	6.6	1.5	-0.3	0.1	1.2	2.5	1.0	0.4	-0.0	2.6	-0.5	0.2
Pulse rate	1.3	2.2	5.0	-0.2	-0.9	-1.3	-1.5	-2.1	-1.0	-1.0	2.2	-1.8	-1.9	-1.2
Happiness	0.6	0.7	2.7	-1.2	0.1	-0.1	-1.6	-0.6	1.0	-0.3	0.5	-0.4	1.0	0.4
Noisy workplace	0.2	0.3	1.2	-0.4	0.2	0.2	-0.5	0.1	1.1	0.0	-0.7	-0.0	0.7	0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	11.6	3.4	0.1	-0.5	1.3	0.2	-1.1	-0.4	3.3	1.1	-1.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.4	-1.0	0.1	-0.5	-1.6	-0.8	0.7	-0.1	-0.1	-0.9	-0.1	-0.1
Mouth/teeth dental problems: Dentures	1.4	2.4	6.1	-1.6	1.7	1.8	0.3	0.3	-0.6	2.5	-1.6	1.0	1.8	2.1
Asthma	0.9	1.7	4.8	-0.5	2.2	1.7	0.6	-0.7	0.1	1.8	-0.8	1.9	-0.9	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.9	-0.5	-0.2	-0.6	-1.2	-0.4	1.7	-1.0	-0.9	-1.3	0.7	-0.4
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.1	-0.7	-0.5	-0.4	-0.3	-0.7	-0.4	-1.0	0.2	-0.6	-0.8
Depression (self-reported)	0.6	0.7	3.3	0.1	-0.7	-0.8	-0.1	1.1	1.8	-0.4	-0.6	0.5	-0.9	-1.0
Medication: Lansoprazole	0.7	0.8	1.7	0.9	1.0	1.0	0.1	-1.1	-1.3	0.7	0.3	0.5	0.6	1.3
Prospective memory result	1.9	2.3	10.8	-0.6	0.1	-0.5	-1.0	-3.3	1.0	-1.0	2.6	-1.9	0.8	0.3
Lung cancer (father)	0.3	0.4	1.4	0.8	-0.1	0.2	-0.7	0.2	-1.2	-0.1	0.6	-0.9	0.7	0.2
Illnesses of mother	0.6	0.7	3.6	0.1	0.1	-0.0	-0.2	0.2	1.9	0.7	0.9	1.6	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.8	1.0	-0.5	-0.5	1.2	1.8	1.2	0.2	1.0	2.2	-1.1	-0.2
Pulse wave Arterial Stiffness index	4.4	5.2	9.9	-0.5	-2.7	-2.2	-3.1	-1.9	1.7	-2.8	2.7	-2.7	-0.8	-2.3
Impedance of arm (left)	0.2	1.1	5.1	-1.4	-0.5	-0.3	0.1	1.8	1.1	-0.2	-2.3	0.2	-0.4	-0.6
Arm fat mass (right)	0.5	2.1	8.6	-1.0	-0.3	-1.4	-1.6	-2.8	0.6	0.4	2.9	-0.5	-0.5	-0.7
Trunk predicted mass	1.7	9.6	64.6	2.2	-2.1	-2.7	-0.4	0.8	2.1	-1.0	8.0	-0.7	-3.6	-2.1
Standing height	1.8	18.2	90.8	2.7	-2.9	-2.8	1.1	5.3	3.9	-0.6	9.5	-0.2	-5.7	-2.7
Length of working week for main job	0.8	0.8	3.2	-1.3	-0.4	-0.4	-1.8	-0.8	-0.6	-0.2	-1.3	0.5	-0.9	-0.3
Exposure to tobacco smoke at home	0.6	0.7	2.3	-1.5	-0.7	-0.6	-0.4	-0.3	1.5	-0.9	0.1	-0.6	-0.1	-0.6
Breastfed as a baby	0.5	0.7	2.3	0.3	-0.1	0.2	1.5	1.2	-0.5	0.6	-0.8	1.1	-1.0	-0.3
Tense / ‘highly strung’	0.8	1.3	8.7	-0.0	0.5	0.4	-1.3	1.2	2.9	-0.1	1.2	0.6	0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.6	-1.6	0.2	-0.0	-2.1	-0.1	1.2	-0.2	-0.1	0.4	0.3	-0.1
Hair/balding pattern: Pattern 4	0.3	0.6	2.0	-1.0	0.0	-0.3	-0.7	-1.0	1.4	0.6	-1.0	0.8	-0.5	-0.2
Birth weight of first child	0.5	0.9	3.8	0.5	-0.0	-0.1	-0.3	0.6	1.7	1.0	1.1	1.9	0.1	0.4
Peak expiratory flow (PEF)	1.7	3.9	10.9	2.7	1.3	1.6	2.0	2.8	1.0	1.9	-0.7	3.3	0.1	1.8
Pulse wave reflection index	1.2	1.5	6.2	2.5	0.9	1.3	1.1	0.2	1.0	0.2	-0.4	1.3	1.5	1.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.8	1.9	0.3	-0.1	0.9	0.1	0.1	0.7	1.7	0.9	-1.1	-0.1
Loud music exposure frequency	0.6	0.7	1.7	1.1	-0.4	-0.9	0.2	-1.3	-0.4	-1.3	0.1	-0.9	-1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	10.8	3.3	0.5	0.9	0.7	1.7	1.5	1.1	1.4	3.1	-0.1	0.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	7.2	0.8	-0.9	-1.1	-0.8	0.2	0.7	-0.5	2.7	0.8	-2.0	-1.4
Blood clot in the leg (DVT)	0.5	0.6	2.7	0.4	0.1	-0.4	-0.3	-0.8	-1.3	-1.0	-0.2	-1.6	-0.4	-0.0
Medication: Paracetamol	0.5	0.8	3.2	-0.5	-0.2	-1.0	-1.1	-1.8	0.6	-0.9	0.2	-1.1	0.6	-0.4
Headache pain in last month	0.4	0.7	2.3	0.6	0.8	0.7	-0.5	0.7	1.1	1.1	-0.2	1.5	0.2	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.3	-0.5	1.1	1.1	0.7	0.5	0.0	1.1	-0.5	0.6	-0.5	0.8
Glaucoma (self-reported)	1.5	1.7	4.9	0.6	-1.8	-1.6	-0.2	0.0	-0.2	-1.8	-0.7	0.1	-2.2	-2.0
Gout (self-reported)	2.1	2.8	9.4	2.3	-1.3	-1.1	0.4	0.5	-1.7	-1.8	2.0	-0.8	-3.1	-1.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.1	0.5	-1.4	-1.4	-0.6	-0.7	0.9	-1.3	0.5	-0.9	-0.9	-1.1
Medication: Amlodipine	0.5	0.6	2.4	-0.2	-0.7	0.1	-1.0	0.4	-0.8	-1.0	1.6	-0.9	0.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	-0.2	1.2	0.7	0.4	-1.5	0.7	0.4	0.6	-0.4	0.0	0.7
Birth weight	0.2	0.4	2.2	0.4	-0.3	0.2	-0.1	1.1	0.0	0.4	0.8	1.5	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.1	1.4	-0.6	-0.8	0.1	0.1	0.1	-0.5	0.5	0.9	-0.9	-0.6
High blood pressure (siblings)	0.6	0.9	2.9	0.7	-0.2	-0.5	-0.9	-0.8	-0.7	-1.0	0.8	-1.7	-1.3	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	3.1	1.1	-1.0	-1.1	1.0	1.3	1.1	-0.8	1.6	1.5	-1.8	-0.9
Body fat percentage	0.5	2.0	7.6	-1.6	-0.3	-1.5	-2.1	-2.8	0.9	0.5	1.7	-0.7	-0.3	-0.8
Leg fat percentage (right)	0.8	3.0	12.2	-2.1	-0.5	-1.6	-2.8	-3.5	0.5	-0.2	1.0	-1.8	-0.0	-0.9
Arm fat-free mass (right)	1.7	8.9	65.9	2.0	-1.4	-2.3	-0.5	0.5	2.1	-0.2	8.1	-0.2	-3.6	-1.7
Exposure to tobacco smoke outside home	1.5	2.0	4.5	0.1	-2.1	-2.1	-0.7	-0.6	0.8	-2.0	0.8	-1.4	-1.3	-1.8
Comparative body size at age 10	0.4	1.1	6.1	-1.7	0.8	0.4	-1.0	-2.5	-0.2	0.4	-0.2	0.6	-0.1	0.8
Number of full brothers	0.6	0.8	2.0	0.5	-0.9	-1.0	1.1	-0.8	-0.9	-0.7	-0.7	0.4	-1.4	-1.1
Worry too long after embarrassment	0.3	0.5	3.2	1.8	-0.3	-0.1	-0.1	1.3	-0.5	-0.6	-0.4	-0.1	-0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.6	-0.5	-1.5	-1.2	-0.4	0.0	0.6	-1.0	0.2	0.3	-1.6	-1.5
Wheeze or whistling in the chest in last year	0.8	1.4	5.2	1.0	0.6	-0.2	0.5	0.3	-2.0	0.4	1.8	0.7	-2.3	-0.7
Number of children fathered	1.1	1.3	3.6	1.1	-1.2	-1.4	-0.1	-1.9	0.5	-1.2	1.0	-0.9	-0.9	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.7	-0.9	-1.2	-1.3	-1.3	0.6	0.1	-0.7	-1.3	-0.0	-1.1	-1.2
Age at first live birth	1.1	1.9	5.5	2.0	-0.1	0.3	1.8	2.2	1.3	1.0	2.4	0.9	-0.6	-0.3
Pulse wave peak to peak time	3.6	4.2	8.4	0.6	2.4	2.0	2.9	2.1	-1.2	2.6	-2.0	2.4	0.5	2.1
Health satisfaction	0.3	0.3	0.9	-0.1	0.6	-0.1	-0.9	-0.2	0.7	0.7	-0.1	0.9	-0.6	0.3
Shortness of breath walking on level ground	0.4	0.5	1.1	-1.0	0.6	-0.0	0.4	-0.9	0.9	0.8	1.1	-0.2	-0.2	0.3
Qualifications: College or University degree	0.9	2.9	15.5	0.5	-1.7	-1.2	1.2	0.8	-0.2	-1.5	3.9	-1.3	-1.9	-1.6
Eye problems/disorders: None of the above	1.9	2.2	5.6	-1.0	1.6	2.0	-0.1	1.4	-0.8	2.4	0.2	0.9	1.9	1.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.8	0.0	0.1	0.4	0.2	-0.5	-0.2	-0.0	1.3	-0.5	0.3	0.3
Emphysema/chronic bronchitis	0.7	0.7	3.5	0.1	0.8	0.7	0.1	0.1	-0.1	1.3	0.8	1.9	0.6	0.8
Medication for pain relief, constipation, heartburn	0.8	1.3	4.1	0.4	0.2	0.8	1.8	1.5	-1.3	0.8	-1.2	0.8	-2.0	-0.1
Neck or shoulder pain in last month	1.1	1.6	6.1	-2.5	1.2	0.9	-0.6	-0.5	0.7	1.3	-1.2	0.1	1.7	1.4
Medication: Blood pressure	0.9	1.6	4.3	-0.2	-1.7	-1.2	-1.1	-0.2	-0.3	-2.0	0.9	-2.1	1.1	-1.3
Angina (self-reported)	1.1	1.4	4.7	-0.3	0.5	0.7	1.1	0.0	-1.4	1.4	-2.2	2.0	0.7	0.6
Migraine (self-reported)	0.7	0.9	2.8	0.3	1.6	0.5	-0.3	-1.7	-0.2	0.4	-0.5	0.8	1.0	1.4
Medication: Ibuprofen	0.7	0.8	2.5	-0.2	-0.4	-0.7	-1.1	0.2	1.6	-1.0	-1.6	-0.5	0.3	-0.6
Medication: Allopurinol	2.5	3.3	10.8	1.3	-1.5	-1.2	-1.1	-0.2	-1.8	-1.9	2.7	-1.4	-3.3	-1.7
Medication: Omeprazole	0.9	1.1	5.2	-1.2	0.9	0.4	-0.9	-0.5	1.1	0.9	-0.0	0.3	2.3	0.9
Medication: Seretide 50 evohaler	0.9	1.0	4.9	1.5	0.6	0.2	0.9	-0.3	-0.3	0.4	0.0	1.5	-2.2	-0.1
Mean time to correctly identify matches	0.5	1.0	5.2	-0.9	-0.8	-0.1	0.7	0.7	-0.8	-0.1	2.3	-1.6	0.4	-0.7
Heart disease (mother)	0.6	0.7	2.0	-0.4	-0.5	-0.9	-0.3	-1.3	-0.2	-0.9	0.1	-1.4	-1.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.5	-0.0	1.2	1.1	0.4	0.2	0.2	0.9	0.2	-0.2	1.6	1.4
Whole body fat mass	0.7	2.9	15.6	-0.3	-0.7	-1.9	-1.5	-2.2	1.3	0.2	4.0	-0.7	-1.4	-1.1
Leg fat mass (right)	0.6	2.4	11.3	-0.6	-0.3	-1.5	-1.7	-2.7	0.7	0.2	3.4	-0.9	-0.7	-0.7
Arm predicted mass (right)	1.8	9.1	62.4	1.8	-1.8	-2.6	-0.8	0.5	2.2	-0.6	7.9	-0.3	-3.9	-1.9
Pulse rate, automated reading	3.9	12.6	34.9	-1.6	-3.2	-3.2	-4.1	-1.9	0.4	-3.7	5.5	-5.9	-2.5	-3.1
Alcohol intake frequency.	2.7	6.4	17.4	-3.1	-2.3	-3.0	-4.2	-2.5	1.2	-2.7	-1.1	-2.6	-0.2	-2.4
Comparative height size at age 10	1.7	9.4	47.2	1.2	-1.9	-1.6	0.1	4.8	2.7	-0.3	6.9	-0.5	-4.0	-1.6
Number of full sisters	1.0	1.2	5.1	-2.3	-0.9	-1.1	-1.0	-0.9	-0.3	-0.7	-1.0	-0.8	-1.1	-1.2
Suffer from ‘nerves’	0.5	0.7	2.6	1.6	-1.0	-0.1	-0.0	1.6	0.1	-0.9	0.6	-0.4	-0.8	-0.6
Overall health rating	0.5	1.0	5.5	-0.6	-0.1	-0.2	-2.3	-0.8	1.6	0.4	1.2	-0.2	0.6	-0.0
Chest pain or discomfort	1.0	1.4	5.1	0.8	1.4	0.1	0.1	-1.2	-0.2	1.2	1.0	2.1	-2.3	0.4
Had major operations	0.7	0.9	7.1	0.9	0.0	-0.0	0.5	0.8	0.0	0.3	0.2	0.4	-2.7	-0.8
Age at last live birth	0.4	0.6	4.9	0.4	0.6	-0.1	0.1	-0.5	0.7	0.7	2.2	0.1	-0.4	-0.1
Family relationship satisfaction	0.3	0.3	1.3	0.1	-0.6	-0.6	-0.4	0.3	-0.5	-0.7	0.3	-1.1	0.2	-0.6
Leg pain on walking	0.6	0.8	2.2	-1.2	-0.1	0.1	-0.1	1.4	1.4	0.7	0.5	0.3	-1.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	-0.6	0.1	-0.1	-1.0	-0.4	0.2	0.3	-0.7	0.0	1.1	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.1	-0.7	0.6	-0.2	-1.0	-0.7	1.4	-0.4	0.7	-0.8	0.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	3.9	0.2	-0.1	-0.1	0.5	-0.0	-0.3	0.2	1.1	2.0	-0.4	-0.3
Medication: Aspirin	0.8	1.0	7.7	-0.2	0.0	-0.2	-1.4	-1.0	0.0	-0.1	2.8	0.4	0.8	0.3
Supplements: Vitamin C	0.9	1.0	4.2	1.6	0.1	-0.4	1.6	-0.9	-0.5	0.6	2.0	0.5	-0.2	0.0
Knee pain experienced in last month	1.2	1.9	4.2	-0.6	-2.0	-1.9	-1.5	0.3	-0.1	-1.6	0.6	-1.7	-0.8	-2.1
Hypertension (Self-reported)	0.5	1.3	2.4	0.1	1.5	1.5	1.4	-0.3	-0.3	1.4	1.1	0.3	1.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.1	0.3	-0.1	-0.2	-0.3	-0.2	1.1	0.2	0.7	1.5	-0.2	-0.1
Illnesses of father: Heart disease	0.3	0.5	1.2	-1.1	-0.3	-0.4	0.5	-0.6	0.6	-0.3	-1.1	0.4	-0.8	-0.7
Illnesses of siblings: Diabetes	0.7	0.9	3.1	-0.1	0.6	1.3	1.8	1.2	0.1	1.2	0.6	-0.2	0.4	0.9
Smoking status: Previous	0.5	0.7	1.5	1.0	-0.8	-0.4	1.0	0.2	-0.5	-1.1	1.2	-0.5	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	15.0	1.4	-1.5	-1.6	-0.5	2.2	2.6	-0.2	3.9	1.2	-2.4	-1.5
Whole body fat-free mass	1.6	9.0	64.3	2.3	-1.7	-2.4	-0.2	0.6	1.6	-0.6	8.0	-0.4	-3.6	-1.9
Leg fat-free mass (right)	1.2	6.6	50.0	2.5	-0.8	-1.7	0.3	0.2	0.8	0.1	7.1	0.1	-3.1	-1.2
Arm fat percentage (left)	0.5	1.9	12.2	-1.7	0.5	-0.7	-1.8	-3.5	0.1	0.9	0.6	-0.1	0.6	0.0
Average weekly red wine intake	0.6	0.8	2.4	-0.9	-1.5	-0.9	-1.3	0.7	-1.1	-1.1	0.2	-0.1	0.3	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.9	0.4	0.9	0.4	1.7	-0.3	-0.2	0.6	-1.7	0.5	-0.7	0.4
Mood swings	0.7	1.3	5.2	-0.1	-0.7	-1.4	-2.3	-0.2	1.3	-1.3	0.1	0.3	-1.3	-1.0
Loneliness, isolation	1.0	1.4	3.3	-0.8	-1.7	-1.6	-0.5	-0.5	0.7	-1.6	0.7	-1.8	0.5	-1.1
Long-standing illness, disability or infirmity	0.3	0.5	1.2	-0.7	0.7	0.8	0.3	0.4	-0.8	1.0	-0.6	1.1	-0.4	0.6
Ever had bowel cancer screening	1.5	1.8	3.5	1.9	1.8	1.7	1.4	0.6	-0.3	1.7	0.5	-0.0	1.2	1.6
Diabetes diagnosed by doctor	0.2	0.4	1.0	-0.8	-0.7	-0.6	-0.8	-0.5	-0.6	0.4	-0.2	1.0	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.7	1.4	2.2	1.3	1.4	-1.3	-0.2	1.4	-0.2	1.0	1.0	1.6
Friendships satisfaction	0.4	0.5	2.7	-0.8	0.7	0.6	-0.8	-0.2	-0.1	0.4	0.5	0.1	1.6	0.9
Qualifications: nursing, teaching	0.6	0.9	3.8	1.9	0.7	0.3	1.6	0.3	0.1	0.4	1.4	0.7	0.5	0.6
Commuting to job workplace: Walk	1.1	1.2	3.0	1.5	-1.7	-1.3	0.5	0.5	-0.0	-1.7	-0.1	-0.1	-0.7	-1.5
Eye problems/disorders: Cataract	0.5	0.5	2.2	-0.2	-0.3	-1.1	-0.2	-1.5	0.3	-0.6	0.5	0.2	-0.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.5	0.4	-1.3	-0.8	-0.7	0.9	1.6	-0.9	0.3	-1.2	1.0	-0.7
Medication for cholesterol	1.7	2.5	4.7	0.1	-2.0	-2.0	-1.0	-0.0	1.2	-2.2	-0.2	-2.1	-2.0	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	5.3	1.7	2.1	1.7	1.4	-0.7	0.8	2.3	0.6	1.0	1.5	2.1
Back pain experienced in last month	0.4	0.6	1.2	1.1	0.7	0.5	-0.4	-0.8	0.7	0.5	0.7	0.7	1.1	1.0
Mineral and other dietary supplements	0.4	0.6	2.3	1.2	0.4	-0.1	-0.4	-1.5	-0.6	-0.1	-0.4	-0.3	-1.2	-0.2
Breast cancer (self-reported)	1.0	1.1	3.6	-1.9	0.9	0.9	0.7	0.7	-0.7	1.9	0.3	0.5	0.9	1.0
Asthma (self-reported)	0.5	1.0	2.7	-0.5	1.6	1.1	0.2	-0.7	0.1	1.2	-0.6	1.3	-1.2	0.9
Osteoporosis (self-reported)	0.9	1.2	4.5	0.5	1.0	1.5	0.6	2.1	0.0	1.2	-0.6	1.2	0.3	1.0
Osteoarthritis (self-reported)	0.2	0.2	0.8	-0.9	0.2	0.4	-0.7	0.3	-0.5	0.1	-0.2	0.1	0.6	0.3
Medication: Aspirin	0.5	0.7	4.8	0.2	0.2	0.1	-1.0	-0.6	-0.3	0.0	2.2	0.3	0.9	0.4
Medication: Gliclazide	0.3	0.3	1.1	0.4	-1.0	-0.9	-0.5	0.0	0.0	-0.4	-0.7	-0.2	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	0.4	0.6	0.4	-0.1	0.0	-0.8	0.6	0.2	0.1	0.6	0.8
Smoking status: Current	0.9	1.4	4.3	1.2	0.2	0.9	2.1	1.4	-0.7	0.9	-0.2	2.0	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	14.2	0.4	2.4	2.8	1.4	0.4	-0.6	1.9	-3.1	2.8	3.8	3.2
Whole body water mass	1.5	8.6	64.2	2.1	-1.5	-2.2	-0.3	0.5	1.6	-0.4	8.0	-0.2	-3.5	-1.7
Leg predicted mass (right)	1.2	6.5	50.1	2.5	-0.8	-1.7	0.3	0.2	0.8	0.1	7.1	0.1	-3.0	-1.2
Arm fat mass (left)	0.6	2.3	10.0	-0.7	-0.2	-1.4	-1.7	-2.8	0.6	0.4	3.2	-0.3	-0.8	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	0.4	0.6	0.0	-0.8	-1.0	0.1	-0.1	-0.2	-0.2	-0.2	0.2
Average weekly champagne plus white wine intake	3.0	4.1	17.6	2.7	-1.6	-2.1	-0.8	-0.7	1.0	-2.0	4.2	-0.9	-1.8	-1.6
Miserableness	0.4	0.8	3.6	1.9	0.6	0.4	0.4	1.6	-0.3	0.2	0.9	0.5	-0.4	0.4
Guilty feelings	1.6	2.4	4.2	-1.0	-1.9	-2.0	-1.9	-0.2	-1.0	-2.0	-0.3	-1.8	-1.2	-2.0
Wears glasses or contact lenses	0.5	0.5	2.2	1.5	-0.8	-0.4	0.3	0.9	0.1	-1.2	0.1	0.1	-0.6	-0.6
Ever taken oral contraceptive pill	0.4	0.5	3.6	-0.7	0.1	-0.1	-0.1	-0.4	0.2	0.7	0.3	1.9	0.7	0.2
Hearing aid user	0.8	0.9	2.0	-0.0	-1.0	-0.9	-1.2	-1.0	-0.6	-1.3	0.3	-1.4	-0.6	-1.1
Mother’s age at death	0.7	0.9	3.3	1.6	0.2	-0.0	0.3	-1.1	-1.2	-0.4	0.7	-1.8	-0.7	-0.2
Financial situation satisfaction	0.6	0.7	2.0	-1.2	-0.1	-0.5	-1.4	-0.3	-0.2	-0.9	-1.3	-1.3	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	0.9	-0.7	-0.8	0.9	-0.6	0.8	-1.1	0.5	-0.4	-0.4	-0.8
Commuting to job workplace: Public transport	1.1	1.3	4.6	1.7	-0.7	-0.3	1.0	1.0	-2.2	0.1	-0.6	0.2	-1.7	-0.8
Eye problems/disorders: Glaucoma	1.4	1.7	5.0	0.5	-1.6	-1.7	-1.1	-0.3	0.2	-2.2	-0.2	-1.0	-1.5	-1.8
Medication: Blood pressure	2.5	4.9	10.3	-0.0	3.1	3.0	1.6	0.0	-0.6	3.2	1.0	2.4	2.2	3.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	6.3	-2.5	0.8	0.9	-0.7	0.4	0.0	1.2	-0.4	-0.8	1.9	1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	4.6	0.0	-0.5	0.1	0.4	2.2	1.3	-0.0	0.4	0.3	0.9	-0.0
High cholesterol (Self-reported)	0.2	0.4	2.6	-0.3	0.3	0.2	-0.5	-0.3	-1.6	0.7	0.2	-0.2	-0.6	-0.1
Medication: Bendroflumethiazide	1.6	2.5	5.8	0.1	1.7	2.4	1.0	2.0	-1.6	2.3	-0.3	1.1	1.1	1.8
Medication: Paracetamol	0.2	0.4	1.6	-0.3	-0.1	-0.6	-0.7	-1.3	0.2	-0.7	0.1	-0.8	0.7	-0.2
Medication: Lisinopril	0.5	0.7	4.9	-2.2	-0.1	0.5	-0.7	0.4	0.2	0.4	-0.3	-0.4	1.1	0.2
Medication: Atorvastatin	0.6	0.7	1.6	-1.0	-0.9	-0.3	-1.3	0.3	-1.2	-0.3	0.1	-1.2	-0.5	-1.0
Illnesses of father: High blood pressure	1.3	1.6	6.7	-0.8	-1.4	-1.4	-0.6	0.1	1.2	-1.3	0.4	-2.6	0.2	-1.6
Alcohol drinker status: Never	3.7	4.4	9.5	-2.1	-2.6	-2.5	-2.7	-1.1	-0.1	-2.7	-0.4	-3.1	0.2	-2.3
Ever smoked	0.7	1.3	5.6	0.9	0.1	0.8	2.4	2.1	-0.6	0.2	1.0	0.8	-1.0	0.0
Basal metabolic rate	1.5	8.2	59.6	1.9	-1.6	-2.4	-0.5	0.2	1.7	-0.4	7.7	-0.3	-3.4	-1.8
Leg fat percentage (left)	0.6	2.3	12.2	-1.7	-0.0	-1.3	-2.2	-3.5	0.4	0.2	1.0	-1.4	0.4	-0.5
Arm fat-free mass (left)	1.6	8.2	60.8	1.6	-1.6	-2.4	-0.7	0.1	1.9	-0.4	7.8	-0.7	-3.3	-1.8
Number of operations (self-reported)	0.5	0.7	3.0	0.5	1.1	0.5	-0.2	-1.0	-0.2	0.9	1.7	0.5	-0.3	0.6
Average weekly beer plus cider intake	0.8	1.1	3.1	-0.2	1.0	1.2	0.5	0.4	1.5	1.1	-1.8	1.6	-0.1	0.9
Irritability	0.6	1.1	3.3	0.7	1.0	0.8	0.8	1.4	0.2	1.6	-0.1	1.8	0.4	0.7
Risk taking	0.4	0.6	3.2	-0.6	0.3	0.2	0.8	0.8	0.8	0.8	-0.2	1.8	-0.4	0.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.0	0.8	-1.3	-1.3	-0.1	-0.3	-0.8	-1.6	1.4	-1.7	-0.5	-1.4
Fractured/broken bones in last 5 years	0.4	0.5	1.8	1.4	0.1	-0.4	-0.2	-0.4	0.9	0.5	1.3	1.0	0.2	-0.1
Age started oral contraceptive pill	0.8	1.0	4.6	1.8	0.7	0.8	1.1	0.3	-0.2	0.6	2.1	0.0	-0.2	0.5
Diastolic blood pressure, automated reading	0.5	1.5	3.0	-0.2	1.5	1.7	1.6	0.5	-1.0	1.0	-1.1	0.4	1.5	1.7
Ever depressed for a whole week	0.7	0.9	2.6	1.1	1.6	0.4	0.2	-0.9	-0.7	0.6	1.5	0.9	-0.0	1.0
Unable to work because of sickness or disability	0.7	1.0	2.3	-1.4	-0.4	-1.0	-1.0	-1.2	-1.5	-0.1	-0.8	-0.6	-0.9	-1.0
Commuting to job workplace: Cycle	2.0	2.5	6.1	1.1	1.3	1.1	2.5	1.5	-1.5	2.0	0.7	1.5	-2.3	0.6
Myopia	2.9	4.2	16.7	2.2	1.3	1.1	1.8	0.8	2.8	1.6	-2.2	4.1	1.1	1.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.1	0.2	-1.7	-1.5	-1.2	1.0	0.3	-1.6	-0.8	-0.3	-2.0	-1.9
Cholesterol lowering medication	1.2	1.8	8.5	-0.5	1.3	0.9	-0.3	-1.2	-2.9	1.7	0.7	1.2	0.8	1.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.7	-0.6	0.7	0.3	-1.1	-0.4	0.5	0.7	0.1	0.4	1.9	0.8
Pain experienced in last month	0.8	1.4	3.1	0.2	-1.5	-1.8	-0.5	-1.2	-0.3	-1.3	0.7	-0.2	-1.6	-1.7
Supplements: Calcium	0.5	0.6	1.5	-0.2	0.6	0.4	1.1	-0.1	-0.6	0.9	1.2	0.8	0.8	0.9
Basal cell carcinoma (self-reported)	1.7	2.0	7.5	-0.7	-1.2	-1.1	-0.3	-0.6	-2.1	-2.3	-0.2	-2.7	-0.3	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	-0.9	0.8	0.2	-0.8	-1.0	-0.4	0.4	-0.5	-1.2	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.7	0.4	0.4	-0.1	0.1	-0.5	-1.1	-0.7	-0.4	-1.3	-0.1	0.3
Heart disease (siblings)	0.7	0.8	3.1	0.0	1.0	0.6	0.4	0.1	-0.3	0.0	-1.6	-1.8	1.0	0.6
Alcohol drinker status: Previous	2.2	2.5	9.0	-2.1	-0.5	-1.4	-1.7	-3.0	1.7	-1.3	-0.4	-1.4	1.2	-0.6
Pack years of smoking	0.5	0.8	4.2	-2.1	0.3	0.9	-0.8	0.4	-0.0	0.7	0.2	-0.5	1.1	0.5
Impedance of whole body	0.5	2.4	8.4	-2.4	-1.0	-0.6	-0.5	2.3	2.1	-0.4	-2.9	-0.1	-0.4	-0.9
Leg fat mass (left)	0.6	2.2	10.6	-0.5	-0.2	-1.5	-1.4	-2.6	0.8	0.4	3.2	-0.7	-0.6	-0.6
Arm predicted mass (left)	1.5	7.8	57.0	1.3	-1.7	-2.4	-1.0	0.0	2.0	-0.6	7.5	-0.8	-3.0	-1.8