Hub : Genes

NGEF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0251	0.0120	4.8e-03	0.005	0.003	0.006	NA	0.005	3.0e-02	7.9e-02	1.4e-02	NA	2.4e-02
2	TCGA	Colon Adenocarcinoma	0.1380	0.0630	7.6e-03	0.027	0.023	0.022	NA	0.031	1.0e-02	1.7e-02	2.0e-02	NA	6.2e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.1633	0.0469	1.7e-07	0.075	0.090	0.063	NA	0.065	8.6e-09	2.7e-10	1.2e-07	NA	7.8e-08
4	TCGA	Brain Lower Grade Glioma	0.0254	0.0132	8.7e-03	0.009	0.011	0.003	NA	0.004	2.9e-02	2.0e-02	1.4e-01	NA	9.2e-02
5	TCGA	Skin Cutaneous Melanoma	0.2770	0.1030	1.0e-03	0.113	0.131	0.185	NA	0.175	6.1e-04	2.3e-04	1.1e-05	NA	2.0e-05
6	TCGA	Thyroid Carcinoma	0.0420	0.0210	4.0e-03	0.032	0.021	0.030	NA	0.029	3.7e-04	3.7e-03	5.6e-04	NA	7.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	4.1	6.5	15.4	1.9	3.9	1.9	0.2	2.8	-2.9
Bipolar Disorder or Schizophrenia	9.1	22.1	40.2	3.3	6.3	4.5	1.1	5.5	-5.5
Depressed Affect (Nagel 2018)	0.8	1.8	4.2	1.5	1.6	0.7	0.6	2.1	0.9
Depression (Nagel 2018)	1.1	1.6	2.9	1.7	1.2	0.4	-1.5	0.7	1.6
Intelligence (Savage-Jansen 2018)	1.3	4.1	15.9	-0.8	-0.8	-0.6	2.7	0.1	-4.0
Neuroticism (Nagel 2018)	0.7	1.7	4.8	0.9	1.4	0.2	1.6	2.2	0.4
Schizophrenia (2018)	7.8	16.1	24.7	2.7	5.0	4.2	1.2	4.8	-4.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.8	0.7	0.2	0.1	0.6	-1.0
Worry (Nagel 2018)	0.3	0.6	1.9	-0.4	0.1	-0.8	1.4	0.7	-0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.1	-0.6	-0.4	0.8	0.2	0.4
Alzheimer’s Disease (in father)	0.7	0.7	2.0	0.2	-0.5	-0.7	-1.2	-0.5	1.4
Alzheimer’s Disease (including proxy)	1.2	1.7	3.3	-0.8	-1.8	-1.5	-0.5	-1.0	1.7
Crohns Disease (2017)	0.3	0.6	1.8	1.3	1.1	0.0	-0.4	0.5	0.5
Irritable Bowel Disease (IBD)	0.3	0.8	2.5	1.6	1.3	0.1	-0.1	0.7	0.1
Ulcerative Colitis (UC)	0.2	0.3	1.2	1.1	0.6	-0.1	0.2	0.3	-0.1
Major Depression (MDD)	0.7	0.8	2.3	0.7	0.2	-0.4	-1.5	-0.2	1.4
Reaction Time	6.0	11.5	23.3	2.6	4.6	4.8	-1.0	3.6	-2.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.6	0.2	0.1	-0.4	1.2	0.9	-2.1
Breast Cancer	0.9	2.3	5.2	-1.2	-2.3	-1.6	1.0	-1.6	0.8
Ovarian Cancer	0.5	0.7	1.4	1.0	0.3	-0.5	1.2	0.6	-1.0
Prostate Cancer	1.7	2.3	4.3	-0.1	1.2	0.7	2.1	1.9	-2.0
Age at First Birth	0.6	0.9	2.3	-1.1	-0.3	-0.1	1.5	0.5	-1.3
Bipolar Disorder (2011)	4.7	4.6	8.7	0.9	3.0	1.9	1.0	2.9	-2.2
Body Mass Index (BMI) (2010)	0.5	0.6	3.1	-0.2	0.2	0.2	-0.4	-0.6	-1.8
Coronary Artery Disease (CAD)	2.4	2.9	6.3	1.7	2.2	0.5	-2.5	1.2	1.1
Crohns Disease (2012)	0.4	0.6	2.2	0.5	1.1	-0.0	-1.5	0.1	-0.0
Mean Putamen Volume	0.8	0.9	3.1	1.0	0.6	-0.6	-1.8	-0.5	0.6
Fasting Glucose	0.3	0.4	1.6	1.3	0.1	0.4	-0.5	-0.6	-0.2
HbA1C	0.6	0.6	1.7	0.3	-0.3	1.3	-0.5	-0.5	1.2
HDL Cholesterol	0.2	0.4	2.0	-0.4	-0.1	-0.2	0.4	-0.2	-1.4
LDL Cholesterol	0.4	0.7	3.3	0.2	-0.3	0.2	0.9	0.1	-1.8
Lupus	0.9	1.3	5.2	-0.1	0.1	0.8	1.5	0.0	-2.3
Neuroticism (2016)	0.3	0.4	1.7	-0.5	-0.4	-0.6	0.2	-0.1	1.3
Primary Biliary Cirrhosis	0.3	0.5	1.9	-0.1	-0.5	0.2	0.1	-0.8	1.4
Rheumatoid Arthritis	0.6	0.8	4.5	0.6	0.2	0.3	-0.0	0.0	2.1
Schizophrenia (2014)	11.2	24.7	42.1	3.0	6.1	4.7	1.9	5.8	-6.5
Triglycerides	0.2	0.3	0.7	-0.9	-0.7	-0.2	0.4	-0.4	-0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.8	0.1	-0.1	0.5	-1.7	-0.7	1.0
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.2	-0.4	-0.6	-0.3	-0.4
Blood Eosinophil Count	0.7	5.3	13.8	-0.1	1.0	1.0	3.2	2.4	-3.7
Blood Platelet Count	0.6	6.8	24.2	0.6	-1.4	-1.3	-2.9	-2.0	4.9
Blood Red Count	0.3	3.2	13.2	-0.3	0.1	-0.2	3.6	0.6	-2.3
Blood White Count	0.2	1.2	2.7	1.1	1.1	1.1	0.0	0.7	-1.6
Heel T-Score	6.8	54.0	112.4	9.3	10.6	7.8	-3.0	7.2	-1.6
BMI	0.3	1.7	2.7	-1.6	-1.0	0.0	1.6	-1.2	-1.6
Height	4.1	78.4	127.7	3.7	7.6	7.2	11.3	10.2	-10.7
Waist Hip Ratio (WHR)	0.5	2.4	5.8	-1.5	-1.3	-2.4	-0.5	-1.4	1.5
Systolic Blood Pressure	0.2	0.9	2.4	0.5	1.6	0.1	1.0	0.9	-0.9
Smoking Status	1.9	4.6	6.6	2.0	2.5	2.3	1.7	2.6	-1.5
Allergy or Eczema	0.3	0.7	1.8	-0.4	-0.6	1.3	-0.6	0.0	1.2
Cardiovascular Disease	0.3	1.0	3.5	0.8	1.9	-0.1	0.4	1.0	-0.9
Hypothyroidism (self reported)	0.2	0.4	1.6	-0.3	-0.5	-0.0	1.2	-0.6	0.3
Respiratory disease	0.9	2.0	2.7	1.4	1.5	1.4	1.0	1.5	-1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.0	1.0	0.8	-0.6	-1.7	0.5	1.2
Lung FEV1/FVC ratio	0.6	3.2	7.7	-2.1	-2.4	-2.8	0.5	-0.8	0.9
Lung FVC	0.9	4.7	12.1	0.1	-1.5	-0.4	-3.5	-2.6	2.6
Neuroticism	0.7	1.7	4.5	0.8	1.4	0.1	1.7	2.1	-0.0
Chronotype (morning person)	2.6	6.0	11.6	-1.5	-3.0	-1.6	-2.2	-2.5	3.4
Hair Pigment	0.3	8.8	29.6	0.0	1.3	0.8	5.4	2.9	-3.5
Tanning	0.1	1.4	4.9	1.1	0.5	-0.9	-0.6	0.9	2.2
Hand grip strength (left)	0.7	1.8	3.8	0.1	0.7	1.1	1.9	1.4	-1.8
Number of treatments/medications taken	0.4	0.6	1.5	-0.5	0.8	1.2	0.0	0.1	-1.2
Average weekly spirits intake	1.9	2.3	6.8	0.2	1.1	1.5	2.6	1.3	-1.6
Sensitivity / hurt feelings	0.8	1.3	4.0	-0.6	0.2	-0.2	2.0	1.8	0.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.7	1.3	0.8	0.3	-1.5	0.6	1.6
Hearing difficulty/problems: Yes	1.9	3.0	9.0	-1.6	-0.2	0.0	3.0	1.1	-2.3
Relative age of first facial hair	0.7	1.4	2.9	1.1	1.7	1.6	-0.6	1.2	0.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.8	0.8	1.4	1.7	0.7	1.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	2.1	-0.4	-0.2	-0.9	-0.4	-0.3	1.4
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	1.4	0.9	0.5	0.1	1.2	0.7
Systolic blood pressure, automated reading	0.2	0.6	1.4	0.3	0.9	0.7	1.2	0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.0	1.4	0.7	-0.0	0.1	0.7	-0.3
Angina	1.0	1.4	5.5	-0.5	-0.7	0.3	-2.3	-1.0	0.9
Medication for hormone replacement therapy	0.7	0.8	2.0	-0.5	-1.1	-1.4	-0.4	-0.4	0.9
Vitamin and mineral supplements	0.0	0.0	0.1	0.0	-0.1	0.2	-0.4	0.1	0.2
Supplements: Zinc	1.2	1.3	2.7	0.8	1.6	1.3	-0.0	1.4	-0.9
Medication: Co-codamol	1.6	1.8	3.2	1.1	1.7	1.8	-0.4	1.7	-0.7
Medication: Metformin	0.7	1.0	2.8	1.1	1.0	-0.5	-1.7	0.5	0.6
Diabetes (father)	0.6	0.8	1.4	-0.9	-0.9	-1.1	0.2	-0.5	1.2
Diabetes (mother)	0.3	0.4	1.0	0.5	0.2	0.3	-0.9	-0.3	1.0
Severe depression (siblings)	0.1	0.1	0.3	-0.2	0.6	0.0	-0.1	-0.2	-0.1
Pack years adult smoking proportion	0.7	1.1	3.5	0.9	0.9	-0.5	-1.9	0.3	1.0
Impedance of leg (right)	1.4	6.7	21.1	2.2	1.1	0.9	-3.5	0.4	4.6
Leg fat-free mass (left)	2.9	15.5	42.5	0.9	2.7	3.2	4.7	3.1	-6.5
Trunk fat percentage	0.2	0.8	2.7	0.7	1.0	1.6	0.3	0.1	-0.5
Hand grip strength (right)	1.4	3.7	6.3	0.4	1.2	2.4	2.5	1.6	-2.5
Townsend deprivation index at recruitment	1.1	1.6	4.9	0.8	0.5	-0.7	-2.2	-0.1	1.8
Current tobacco smoking	0.7	1.1	1.9	1.2	1.4	0.3	0.2	1.4	1.0
Average weekly fortified wine intake	2.3	2.7	7.8	-1.8	-0.9	-1.6	2.8	0.2	-1.3
Maternal smoking around birth	0.3	0.5	1.6	0.1	-0.1	1.3	1.0	-0.1	-0.5
Fed-up feelings	0.2	0.3	1.1	-0.0	0.2	0.3	0.4	0.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	3.1	1.8	1.5	0.3	-1.6	1.1	1.3
Relative age voice broke	1.5	2.4	4.7	1.8	2.2	1.1	0.8	2.0	-0.5
Taking other prescription medications	0.3	0.4	1.5	-1.2	-0.2	0.2	0.4	-0.3	-0.7
Age when periods started (menarche)	0.3	0.7	2.1	-0.0	0.5	0.3	1.2	1.5	0.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.7	0.1	-0.5	-2.2	-0.5	-0.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	4.9	11.2	23.6	3.5	4.9	3.5	0.3	4.2	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-0.1	0.4	1.0	0.1	0.5	-0.8
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.5	0.2	-0.6	0.0	-0.3	0.2
Serious illness, injury or assault to yourself	1.1	1.4	2.4	1.3	1.6	1.5	-1.0	1.0	-0.3
High blood pressure	0.7	1.9	4.1	1.2	1.9	0.5	0.6	1.3	-2.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.8	-0.7	1.3	-0.6	-0.2	0.3
Multivitamins +/- minerals	0.2	0.3	0.7	-0.4	-0.3	-0.1	-0.9	-0.4	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.5	0.7	0.3	0.7	0.2	0.3
Supplements: Glucosamine	2.1	2.8	5.8	1.7	1.9	1.4	0.0	2.4	1.5
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.5	-2.1	-1.8	-1.0	-0.3	-2.0	-0.8
Medication: Atenolol	1.9	2.4	5.5	-1.4	-1.3	-2.3	-1.5	-1.7	0.1
Medication: Levothyroxine sodium	0.3	0.5	2.1	-0.5	-0.6	-1.5	0.3	-0.2	0.6
Sitting height	8.7	61.5	92.4	4.1	7.2	7.3	8.4	9.1	-9.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.0	-0.0	-0.8	1.3	0.4	-1.0
High blood pressure (mother)	1.2	1.6	3.1	1.5	1.8	1.3	0.3	1.6	-0.3
Body mass index (BMI)	0.1	0.3	0.9	-0.1	0.1	0.9	0.3	-0.5	-0.7
Impedance of leg (left)	1.0	4.8	18.5	1.4	0.7	0.1	-2.8	0.2	4.3
Leg predicted mass (left)	2.8	15.0	41.3	0.9	2.7	3.2	4.6	3.1	-6.4
Trunk fat mass	0.8	3.6	6.3	0.9	1.9	2.4	1.8	1.3	-2.5
Waist circumference	0.6	2.0	5.7	-0.1	0.9	1.2	2.0	0.6	-2.4
Number of incorrect matches in round	0.7	1.2	6.6	-0.3	-0.2	-2.6	-0.4	-0.6	-0.0
Past tobacco smoking	2.0	3.6	6.2	-1.4	-1.9	-1.9	-1.3	-2.1	2.5
Alcohol usually taken with meals	1.8	3.0	7.8	-1.5	-0.3	-0.2	2.8	-0.1	-2.8
Nervous feelings	0.2	0.4	1.3	0.1	0.6	1.1	0.5	0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	7.6	1.8	1.0	0.5	-2.8	0.6	2.2
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-0.6	0.2	0.7	1.7	1.1	-1.0
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.6	0.4	0.9	-0.4	-0.4	-0.5
Had menopause	0.2	0.2	0.6	0.8	0.7	0.4	-0.3	0.3	-0.0
Had other major operations	1.3	1.6	2.2	-1.2	-1.4	-1.5	1.2	-0.9	-1.2
Forced vital capacity (FVC)	0.7	2.8	9.1	2.1	1.2	3.0	-0.3	0.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	5.1	11.6	25.3	3.8	5.0	3.0	0.4	4.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.1	-0.1	0.6	1.1	-0.3	0.1	-0.5
Qualifications: None of the above	1.1	2.4	5.2	-0.6	-0.9	-1.4	-2.0	-1.3	2.3
Financial difficulties in last 2 years	0.8	1.1	2.9	0.1	0.3	1.7	-1.4	-0.9	0.8
Mouth/teeth dental problems	0.4	0.6	1.7	0.9	0.7	1.3	0.0	0.9	-0.1
Heart attack	0.8	1.0	1.6	1.0	1.0	1.3	-1.1	1.1	0.3
Allergy	0.1	0.3	1.0	0.5	0.3	-1.0	0.5	-0.2	-0.2
Pain all over the body in last month	1.3	1.4	4.8	0.0	-0.6	0.4	-2.2	-1.4	1.0
Diabetes (self-reported)	0.6	1.0	2.8	0.1	0.2	-1.7	-0.9	0.1	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.3	-0.5	-0.6	1.5	0.3	-0.3	-0.2
Medication: Ramipril	1.6	2.0	4.1	1.6	2.0	2.0	-0.4	1.1	-0.1
Medication: Simvastatin	0.4	0.6	1.2	0.4	0.9	-1.0	0.6	1.1	-0.4
Fluid intelligence score	0.2	0.4	1.2	-0.4	-0.7	-1.1	0.5	-0.3	-0.6
Illnesses of siblings	2.6	3.6	7.8	-1.0	-2.2	-2.8	-1.1	-2.5	0.5
Neuroticism score	0.5	1.0	3.1	0.0	0.7	0.0	1.5	1.8	-0.1
Weight	2.1	10.2	20.5	1.2	2.7	3.3	3.7	2.8	-4.5
Impedance of arm (right)	0.6	2.9	9.0	0.8	-0.4	-0.1	-3.0	-1.2	2.5
Arm fat percentage (right)	0.2	0.9	2.5	0.5	0.3	1.2	-1.6	-0.9	0.5
Trunk fat-free mass	4.1	23.3	47.7	1.7	3.9	4.1	5.7	5.0	-6.9
Hip circumference	1.4	6.2	13.3	1.1	1.9	2.8	2.7	1.9	-3.6
Time employed in main current job	0.2	0.3	0.6	-0.4	0.5	0.6	-0.8	-0.4	-0.2
Alcohol intake versus 10 years previously	0.9	1.3	2.5	-0.1	-1.2	-1.0	-1.6	-0.8	1.4
Father’s age at death	1.2	1.7	8.1	0.2	0.1	0.0	2.8	0.8	-1.0
Worrier / anxious feelings	1.0	2.0	4.0	-2.0	-1.6	-2.0	0.9	-0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	6.5	0.9	0.6	0.8	-2.2	-0.0	2.5
Falls in the last year	0.4	0.6	1.2	-0.6	-0.3	-0.8	-1.0	-1.1	0.2
Hair/balding pattern: Pattern 3	1.7	2.6	4.7	-2.2	-1.0	-1.5	2.1	-0.0	-1.7
Number of live births	0.2	0.3	0.8	0.9	0.4	0.9	-0.2	-0.0	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.9	0.7	-0.3	1.4	-0.4	-0.4	-0.4
Pulse rate	1.7	2.8	6.2	1.8	2.5	1.8	0.9	1.5	-1.1
Happiness	0.3	0.4	1.8	0.3	0.3	0.5	-1.3	-0.2	0.5
Noisy workplace	0.5	0.6	1.8	-0.5	0.2	0.1	-1.4	-0.3	1.1
Qualifications: A levels/AS levels or equivalent	2.8	6.3	17.5	-0.3	0.7	0.8	4.2	1.9	-3.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	-1.0	-0.6	-0.6	0.1	-1.4	0.2
Mouth/teeth dental problems: Dentures	1.4	2.4	7.6	-0.1	-1.1	-1.6	-1.4	-1.0	2.8
Asthma	0.4	0.7	1.2	0.9	0.9	1.1	-1.1	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.2	-1.8	-1.3	-1.4	-0.3	-0.9	1.1
Medication: Cholesterol lowering	0.2	0.4	1.0	-0.4	-0.0	-0.3	-1.0	-0.3	0.9
Depression (self-reported)	0.3	0.4	1.0	0.1	-0.2	-0.9	-1.0	-0.2	0.6
Medication: Lansoprazole	0.2	0.2	0.4	-0.5	-0.5	0.5	0.4	-0.6	0.1
Prospective memory result	1.8	2.2	9.1	0.7	1.5	3.0	-0.2	0.3	-1.0
Lung cancer (father)	0.5	0.5	2.7	0.0	0.2	1.6	0.4	-0.0	-0.5
Illnesses of mother	0.6	0.8	1.9	-1.3	-0.7	-1.4	0.2	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.1	0.5	-0.0	0.5	-0.0	-0.2	-1.1
Pulse wave Arterial Stiffness index	1.3	1.5	5.1	1.1	1.2	2.2	-0.7	0.2	-0.8
Impedance of arm (left)	0.4	2.1	5.6	0.8	-0.4	-0.1	-2.2	-1.1	2.4
Arm fat mass (right)	0.6	2.4	5.8	1.2	1.7	2.4	0.5	1.1	-1.7
Trunk predicted mass	4.1	23.4	47.3	1.8	3.9	4.1	5.7	5.0	-6.9
Standing height	4.0	40.1	67.2	2.9	5.5	5.2	7.6	7.1	-8.2
Length of working week for main job	0.7	0.8	3.5	-0.1	-0.2	0.1	-1.0	-0.3	1.9
Exposure to tobacco smoke at home	0.6	0.7	2.1	0.4	1.3	0.4	-1.4	0.2	-0.3
Breastfed as a baby	0.5	0.6	1.6	0.9	0.7	1.2	0.6	0.3	-0.5
Tense / ‘highly strung’	1.4	2.4	5.2	2.1	2.3	1.0	0.2	1.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.2	-0.1	-0.3	0.3	-1.5	-0.5	2.0
Hair/balding pattern: Pattern 4	0.5	1.2	3.9	0.8	-0.1	-0.3	-2.0	-0.7	1.5
Birth weight of first child	0.7	1.4	4.8	0.0	0.6	-0.3	2.2	1.5	-0.8
Peak expiratory flow (PEF)	0.8	1.9	4.2	-1.3	-2.1	-0.9	1.7	-1.3	0.1
Pulse wave reflection index	2.1	2.6	6.6	1.8	1.6	2.6	0.2	1.8	0.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.6	-0.3	0.4	1.4	0.7	0.6	-1.6
Loud music exposure frequency	0.3	0.3	0.8	-0.2	-0.6	-0.7	0.9	-0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.4	-0.2	-0.7	0.4	2.3	0.7	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.5	-1.1	-0.3	0.0	0.7	-0.3	-1.6
Blood clot in the leg (DVT)	2.2	2.8	7.1	-0.9	-2.7	-2.0	0.8	-1.6	1.2
Medication: Paracetamol	0.5	0.9	2.2	-1.5	-1.2	0.2	-0.6	-1.1	0.1
Headache pain in last month	1.0	1.7	3.2	0.9	1.2	1.5	1.8	1.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	0.4	-0.4	0.2	0.1	0.1	0.0
Glaucoma (self-reported)	0.7	0.9	4.2	-0.0	-0.8	-2.0	0.4	-0.2	0.5
Gout (self-reported)	2.1	2.9	5.9	0.3	1.4	1.5	2.4	1.5	-2.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	-1.1	-0.9	-0.6	1.2	-0.7	0.0
Medication: Amlodipine	0.2	0.2	1.0	-0.5	0.4	-0.1	-0.2	0.1	-1.0
Medication: Ventolin 100micrograms inhaler	2.7	3.5	10.1	1.5	2.4	3.2	-0.9	0.6	-1.3
Birth weight	0.4	0.9	1.5	1.0	0.8	0.4	1.1	1.2	-0.9
Chronic bronchitis/emphysema (mother)	1.8	2.1	9.0	1.3	1.3	3.0	-0.2	0.3	-0.5
High blood pressure (siblings)	3.1	4.5	10.3	1.4	1.9	3.2	2.0	2.6	0.2
Forced vital capacity (FVC), Best measure	0.5	1.9	3.8	1.7	1.2	1.9	0.2	0.6	-1.7
Body fat percentage	0.2	0.7	2.7	0.7	0.9	1.6	-0.4	-0.2	0.0
Leg fat percentage (right)	0.4	1.5	3.7	1.3	1.0	1.9	-1.2	-0.2	1.1
Arm fat-free mass (right)	4.1	21.0	43.7	1.7	3.7	3.7	5.5	4.7	-6.6
Exposure to tobacco smoke outside home	1.5	2.0	4.3	1.1	2.0	1.4	0.6	2.1	0.3
Comparative body size at age 10	0.5	1.5	6.0	0.8	0.2	0.9	-2.4	-0.5	1.2
Number of full brothers	0.4	0.5	1.3	0.5	1.1	0.5	0.2	0.9	0.4
Worry too long after embarrassment	0.6	1.0	4.1	-0.8	-1.0	-0.5	2.0	-0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.3	1.5	2.0	0.5	-0.4	2.1	-0.0
Wheeze or whistling in the chest in last year	1.3	2.3	6.1	0.1	1.5	1.1	1.6	1.3	-2.5
Number of children fathered	1.9	2.2	10.4	1.3	0.6	3.2	0.4	0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	5.0	-0.7	-1.9	-2.2	0.2	-1.1	1.3
Age at first live birth	1.5	2.6	11.7	-1.2	-0.0	0.3	1.6	0.1	-3.4
Pulse wave peak to peak time	0.7	0.8	2.4	-0.7	-0.6	-1.5	1.2	0.5	0.3
Health satisfaction	0.4	0.5	1.0	0.1	-0.4	0.5	-0.9	-0.7	1.0
Shortness of breath walking on level ground	0.2	0.2	0.7	0.2	0.2	0.1	-0.9	-0.2	-0.6
Qualifications: College or University degree	3.4	10.7	26.4	1.2	3.1	2.9	2.7	3.3	-5.1
Eye problems/disorders: None of the above	0.6	0.7	1.7	-1.3	-0.9	-0.2	-0.4	-1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.2	0.5	0.5	0.9	1.3	-0.0	-1.5
Emphysema/chronic bronchitis	2.0	2.2	4.9	1.1	2.0	2.2	-0.5	1.6	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.8	0.1	0.1	-0.1	0.5	0.6
Neck or shoulder pain in last month	1.3	1.8	5.9	0.2	0.2	-0.2	-2.4	0.3	2.1
Medication: Blood pressure	0.1	0.1	0.4	-0.5	0.2	-0.2	-0.2	-0.2	-0.6
Angina (self-reported)	1.4	1.9	7.3	-0.5	-0.9	0.0	-2.7	-1.2	1.2
Migraine (self-reported)	1.9	2.4	4.2	-1.4	-2.0	-2.1	0.7	-1.7	1.1
Medication: Ibuprofen	1.3	1.6	2.8	-1.6	-1.0	-1.5	-0.4	-0.9	1.7
Medication: Allopurinol	2.9	3.9	6.2	1.8	2.2	2.5	1.5	2.0	-1.7
Medication: Omeprazole	0.8	1.0	2.6	-0.7	-0.6	-0.4	-1.6	-1.3	0.8
Medication: Seretide 50 evohaler	0.6	0.7	2.1	1.0	0.4	-0.2	1.5	1.1	0.0
Mean time to correctly identify matches	3.8	7.2	14.3	1.5	3.6	3.8	-0.8	2.5	-2.5
Heart disease (mother)	0.1	0.1	0.3	0.3	0.1	0.1	-0.5	-0.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.1	-1.5	-1.3	-1.0	0.9	-0.8	0.7
Whole body fat mass	0.8	3.5	5.9	0.9	2.0	2.4	1.6	1.5	-2.4
Leg fat mass (right)	0.6	2.5	5.8	1.2	1.9	2.4	0.9	1.2	-1.5
Arm predicted mass (right)	3.8	19.3	41.0	1.6	3.6	3.7	5.2	4.3	-6.4
Pulse rate, automated reading	2.6	8.4	12.4	1.9	3.1	2.8	2.8	3.1	-3.5
Alcohol intake frequency.	3.1	7.2	13.6	-1.2	-2.8	-1.6	-3.1	-3.7	2.9
Comparative height size at age 10	3.0	16.3	27.4	1.7	2.9	3.5	5.2	4.4	-5.2
Number of full sisters	3.6	4.4	8.3	2.3	1.8	2.9	-2.3	0.9	1.8
Suffer from ‘nerves’	1.0	1.5	4.5	-0.1	1.0	0.6	1.4	2.1	-1.1
Overall health rating	0.7	1.4	2.4	1.4	1.6	1.3	-1.0	1.2	-0.1
Chest pain or discomfort	1.3	1.9	5.6	0.6	1.5	0.1	1.4	2.4	-1.0
Had major operations	2.0	2.4	4.7	1.8	2.1	2.2	-0.6	1.2	-0.4
Age at last live birth	0.9	1.4	6.1	0.1	0.7	1.2	-0.1	-0.2	-2.5
Family relationship satisfaction	1.4	1.7	4.6	1.1	1.6	2.1	-0.2	1.2	0.1
Leg pain on walking	0.4	0.5	1.3	0.3	1.1	0.6	-1.1	0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.4	-0.7	-1.1	-0.9	-0.1	-1.2	0.9
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.3	0.4	0.7	-0.5	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	-0.2	0.0	-0.3	-0.1	0.5	-0.9
Medication: Aspirin	1.0	1.3	4.5	0.1	0.9	-0.6	1.3	0.9	-2.1
Supplements: Vitamin C	0.9	1.1	3.4	-0.7	0.3	-0.5	1.9	0.7	-1.3
Knee pain experienced in last month	0.9	1.3	3.7	0.7	1.0	1.4	1.0	1.9	0.1
Hypertension (Self-reported)	0.5	1.5	3.4	0.9	1.7	-0.0	0.6	1.2	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	5.3	0.6	0.9	2.3	-0.6	0.6	0.1
Illnesses of father: Heart disease	1.9	2.7	7.3	1.9	1.7	1.4	-2.7	-0.0	0.6
Illnesses of siblings: Diabetes	0.6	0.7	2.5	-0.1	1.0	0.5	0.0	1.6	-0.6
Smoking status: Previous	1.3	1.9	5.4	0.7	1.0	1.6	0.8	1.2	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	12.1	0.8	1.5	1.7	3.5	2.2	-3.0
Whole body fat-free mass	3.8	21.7	50.7	1.3	3.5	3.7	5.7	4.4	-7.1
Leg fat-free mass (right)	3.0	15.8	46.1	0.3	2.4	2.6	5.2	3.0	-6.8
Arm fat percentage (left)	0.2	0.7	1.6	0.4	0.2	1.2	-1.3	-1.1	0.4
Average weekly red wine intake	0.8	1.1	2.9	0.8	0.6	0.1	0.7	1.7	1.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.2	0.2	-0.5	-0.4	-0.1	0.2
Mood swings	1.0	1.8	4.4	1.4	1.3	0.5	-0.6	1.4	2.1
Loneliness, isolation	0.4	0.5	1.4	0.8	1.0	0.0	-0.5	1.2	0.1
Long-standing illness, disability or infirmity	0.6	0.9	1.8	0.8	1.4	1.1	-0.7	1.1	-0.3
Ever had bowel cancer screening	2.9	3.4	7.2	-2.7	-1.6	-1.6	2.2	-1.1	-1.4
Diabetes diagnosed by doctor	0.7	1.1	2.7	0.5	1.1	-0.9	-1.7	0.6	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	0.3	0.0	0.2	-0.1	-0.7	-0.1
Friendships satisfaction	1.1	1.3	2.5	1.2	1.6	1.5	-0.1	1.2	-0.6
Qualifications: nursing, teaching	1.1	1.7	5.4	-0.8	0.2	-0.1	1.9	0.6	-2.3
Commuting to job workplace: Walk	0.6	0.7	2.0	0.2	0.3	0.4	1.4	1.3	-0.2
Eye problems/disorders: Cataract	0.5	0.6	1.9	0.7	0.9	0.0	-1.4	0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.2	0.1	-0.4	0.9	0.7	-0.7
Medication for cholesterol	0.6	0.9	4.1	0.1	0.8	2.0	-0.2	0.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.6	0.2	0.1	1.3	0.5	0.1	-0.8
Back pain experienced in last month	0.4	0.7	2.1	-0.9	-1.5	0.0	0.3	-0.4	0.8
Mineral and other dietary supplements	1.2	1.7	3.8	-1.3	-1.6	-1.1	0.6	-1.9	-0.2
Breast cancer (self-reported)	1.1	1.3	3.6	0.9	1.3	1.0	-1.9	0.6	-0.6
Asthma (self-reported)	0.5	1.0	2.2	1.1	1.1	1.5	-0.9	0.6	-0.6
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.4	-0.5	-1.0	-0.5	-0.4	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.3	-0.3	-1.1	-0.3	0.2	1.2
Medication: Aspirin	1.0	1.3	4.5	-0.2	0.8	-0.8	1.2	0.8	-2.1
Medication: Gliclazide	0.2	0.3	0.5	0.7	0.7	-0.2	-0.3	0.5	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.9	-0.6	-0.2	0.5	-0.2	0.0
Smoking status: Current	1.3	2.1	4.1	1.6	2.0	1.0	0.8	2.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	7.3	-1.8	-2.2	-0.9	-1.6	-2.7	2.1
Whole body water mass	3.8	21.9	49.8	1.6	3.7	3.9	5.5	4.5	-7.1
Leg predicted mass (right)	3.0	16.0	46.2	0.3	2.4	2.6	5.2	3.1	-6.8
Arm fat mass (left)	0.6	2.4	5.4	1.1	1.6	2.3	1.0	1.0	-1.9
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	-0.9	-0.8	-0.6	0.8	-0.3	0.5
Average weekly champagne plus white wine intake	3.4	4.7	12.0	-0.1	1.5	1.2	3.2	1.4	-3.5
Miserableness	2.4	4.2	9.8	1.5	2.5	1.4	2.0	3.1	-0.8
Guilty feelings	0.2	0.2	1.1	-0.4	0.2	0.1	0.2	0.2	1.0
Wears glasses or contact lenses	0.8	0.9	1.7	1.3	1.2	0.6	0.9	1.1	-0.1
Ever taken oral contraceptive pill	0.6	0.7	1.7	-1.0	-0.7	-0.6	-0.5	-1.3	0.1
Hearing aid user	1.1	1.3	2.5	-1.4	-1.4	0.6	1.6	-0.8	-0.6
Mother’s age at death	1.4	1.8	6.9	0.3	0.8	0.5	2.6	1.3	-1.1
Financial situation satisfaction	1.6	1.9	3.8	-0.9	-1.4	-0.9	-1.6	-1.4	1.9
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.5	-1.3	-1.5	-1.6	1.3	-0.7	-0.3
Commuting to job workplace: Public transport	0.7	0.8	3.4	-0.3	-0.2	0.4	1.8	0.3	-1.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.7	0.2	-0.8	-1.9	0.7	-0.2	0.9
Medication: Blood pressure	1.0	1.8	3.7	1.6	1.9	0.5	0.1	1.6	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.6	-0.2	0.2	-0.1	-1.6	-0.3	0.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.4	0.8	1.1	0.1	0.4	1.8	-0.0
High cholesterol (Self-reported)	0.2	0.3	0.8	0.4	0.1	-0.2	0.8	0.9	0.3
Medication: Bendroflumethiazide	1.6	2.5	5.7	-1.8	-1.8	-2.4	-0.3	-1.6	-0.2
Medication: Paracetamol	0.2	0.3	1.1	-1.1	-0.4	0.2	-0.2	-0.5	0.1
Medication: Lisinopril	1.2	1.5	6.9	0.7	0.3	0.1	-2.6	-1.2	-0.0
Medication: Atorvastatin	0.5	0.6	1.2	-0.5	0.7	0.9	-0.3	0.9	-1.1
Illnesses of father: High blood pressure	0.5	0.6	3.1	-0.1	0.6	-0.0	-0.2	0.6	-1.8
Alcohol drinker status: Never	1.6	1.9	3.7	-1.2	-1.2	-1.9	-0.8	-1.7	1.2
Ever smoked	2.3	4.0	6.6	2.3	2.4	1.2	1.3	2.6	-1.8
Basal metabolic rate	3.5	19.6	44.1	1.4	3.5	3.8	5.2	4.2	-6.6
Leg fat percentage (left)	0.2	0.7	2.1	0.6	0.6	1.5	-0.7	-0.4	0.9
Arm fat-free mass (left)	4.1	20.7	40.8	1.9	3.9	4.0	5.1	4.7	-6.4
Number of operations (self-reported)	0.2	0.3	0.7	0.1	-0.3	0.8	-0.0	-0.7	-0.7
Average weekly beer plus cider intake	0.6	0.9	1.5	0.8	1.2	0.3	-0.9	1.2	0.9
Irritability	1.0	1.8	5.6	1.2	1.7	0.8	-0.0	2.4	0.3
Risk taking	0.3	0.4	0.8	0.9	0.7	0.7	-0.7	0.7	0.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.1	-0.4	1.1	1.1	1.8	1.0	-0.5
Fractured/broken bones in last 5 years	1.9	2.4	4.0	-2.0	-1.9	-1.8	-0.7	-1.6	-0.5
Age started oral contraceptive pill	1.4	1.8	8.4	-0.4	0.5	0.0	1.2	0.6	-2.9
Diastolic blood pressure, automated reading	0.2	0.7	1.6	0.3	0.8	0.8	1.3	0.8	-0.7
Ever depressed for a whole week	0.2	0.3	1.0	-0.5	0.3	0.5	0.1	-0.3	-1.0
Unable to work because of sickness or disability	1.5	1.9	3.9	1.6	0.7	1.3	-2.0	-0.4	1.7
Commuting to job workplace: Cycle	0.9	1.1	4.0	0.4	0.0	1.2	-0.2	-0.9	-2.0
Myopia	0.4	0.5	1.0	-0.7	-0.8	0.3	-0.4	-1.0	0.9
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.1	-0.8	-1.3	-0.5	0.3	-0.9	1.4
Cholesterol lowering medication	0.2	0.3	0.8	0.8	-0.1	-0.9	0.4	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-1.0	-0.8	-0.0	-0.3	-0.7	0.6
Pain experienced in last month	0.2	0.3	0.7	0.3	0.1	-0.5	-0.8	-0.4	-0.8
Supplements: Calcium	0.4	0.5	0.8	0.7	0.8	0.9	-0.1	0.5	-0.9
Basal cell carcinoma (self-reported)	2.1	2.5	4.4	1.8	2.1	2.0	-1.1	1.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	0.8	0.8	0.8	-0.7	1.0	0.2
Deep venous thrombosis (DVT) (self-reported)	2.3	3.0	7.3	-1.0	-2.7	-2.2	0.6	-1.7	1.3
Heart disease (siblings)	0.3	0.4	1.4	-0.8	-0.4	-1.2	-0.1	0.5	0.1
Alcohol drinker status: Previous	3.8	4.4	11.7	-1.8	-1.4	-0.8	-3.4	-2.3	1.9
Pack years of smoking	0.4	0.6	2.5	0.2	0.3	-0.6	-1.6	-0.2	0.7
Impedance of whole body	0.7	3.4	12.9	0.7	-0.1	-0.2	-2.6	-0.6	3.6
Leg fat mass (left)	0.6	2.2	4.8	0.9	1.7	2.2	1.0	1.1	-1.5
Arm predicted mass (left)	3.6	18.3	35.6	1.7	3.6	3.8	4.8	4.5	-6.0