Hub : Genes

NGEF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0251 0.0120 4.8e-03 0.005 0.003 0.006 NA 0.005 3.0e-02 7.9e-02 1.4e-02 NA 2.4e-02
2 TCGA Colon Adenocarcinoma 0.1380 0.0630 7.6e-03 0.027 0.023 0.022 NA 0.031 1.0e-02 1.7e-02 2.0e-02 NA 6.2e-03
3 TCGA Head and Neck Squamous Cell Carcinoma 0.1633 0.0469 1.7e-07 0.075 0.090 0.063 NA 0.065 8.6e-09 2.7e-10 1.2e-07 NA 7.8e-08
4 TCGA Brain Lower Grade Glioma 0.0254 0.0132 8.7e-03 0.009 0.011 0.003 NA 0.004 2.9e-02 2.0e-02 1.4e-01 NA 9.2e-02
5 TCGA Skin Cutaneous Melanoma 0.2770 0.1030 1.0e-03 0.113 0.131 0.185 NA 0.175 6.1e-04 2.3e-04 1.1e-05 NA 2.0e-05
6 TCGA Thyroid Carcinoma 0.0420 0.0210 4.0e-03 0.032 0.021 0.030 NA 0.029 3.7e-04 3.7e-03 5.6e-04 NA 7.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 4.1 6.5 15.4 1.9 3.9 1.9 0.2 2.8 -2.9
Bipolar Disorder or Schizophrenia 9.1 22.1 40.2 3.3 6.3 4.5 1.1 5.5 -5.5
Depressed Affect (Nagel 2018) 0.8 1.8 4.2 1.5 1.6 0.7 0.6 2.1 0.9
Depression (Nagel 2018) 1.1 1.6 2.9 1.7 1.2 0.4 -1.5 0.7 1.6
Intelligence (Savage-Jansen 2018) 1.3 4.1 15.9 -0.8 -0.8 -0.6 2.7 0.1 -4.0
Neuroticism (Nagel 2018) 0.7 1.7 4.8 0.9 1.4 0.2 1.6 2.2 0.4
Schizophrenia (2018) 7.8 16.1 24.7 2.7 5.0 4.2 1.2 4.8 -4.8
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.8 0.7 0.2 0.1 0.6 -1.0
Worry (Nagel 2018) 0.3 0.6 1.9 -0.4 0.1 -0.8 1.4 0.7 -0.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 -0.1 -0.6 -0.4 0.8 0.2 0.4
Alzheimer’s Disease (in father) 0.7 0.7 2.0 0.2 -0.5 -0.7 -1.2 -0.5 1.4
Alzheimer’s Disease (including proxy) 1.2 1.7 3.3 -0.8 -1.8 -1.5 -0.5 -1.0 1.7
Crohns Disease (2017) 0.3 0.6 1.8 1.3 1.1 0.0 -0.4 0.5 0.5
Irritable Bowel Disease (IBD) 0.3 0.8 2.5 1.6 1.3 0.1 -0.1 0.7 0.1
Ulcerative Colitis (UC) 0.2 0.3 1.2 1.1 0.6 -0.1 0.2 0.3 -0.1
Major Depression (MDD) 0.7 0.8 2.3 0.7 0.2 -0.4 -1.5 -0.2 1.4
Reaction Time 6.0 11.5 23.3 2.6 4.6 4.8 -1.0 3.6 -2.0
Verbal and Numeric Reasoning (VNR) 0.5 1.2 4.6 0.2 0.1 -0.4 1.2 0.9 -2.1
Breast Cancer 0.9 2.3 5.2 -1.2 -2.3 -1.6 1.0 -1.6 0.8
Ovarian Cancer 0.5 0.7 1.4 1.0 0.3 -0.5 1.2 0.6 -1.0
Prostate Cancer 1.7 2.3 4.3 -0.1 1.2 0.7 2.1 1.9 -2.0
Age at First Birth 0.6 0.9 2.3 -1.1 -0.3 -0.1 1.5 0.5 -1.3
Bipolar Disorder (2011) 4.7 4.6 8.7 0.9 3.0 1.9 1.0 2.9 -2.2
Body Mass Index (BMI) (2010) 0.5 0.6 3.1 -0.2 0.2 0.2 -0.4 -0.6 -1.8
Coronary Artery Disease (CAD) 2.4 2.9 6.3 1.7 2.2 0.5 -2.5 1.2 1.1
Crohns Disease (2012) 0.4 0.6 2.2 0.5 1.1 -0.0 -1.5 0.1 -0.0
Mean Putamen Volume 0.8 0.9 3.1 1.0 0.6 -0.6 -1.8 -0.5 0.6
Fasting Glucose 0.3 0.4 1.6 1.3 0.1 0.4 -0.5 -0.6 -0.2
HbA1C 0.6 0.6 1.7 0.3 -0.3 1.3 -0.5 -0.5 1.2
HDL Cholesterol 0.2 0.4 2.0 -0.4 -0.1 -0.2 0.4 -0.2 -1.4
LDL Cholesterol 0.4 0.7 3.3 0.2 -0.3 0.2 0.9 0.1 -1.8
Lupus 0.9 1.3 5.2 -0.1 0.1 0.8 1.5 0.0 -2.3
Neuroticism (2016) 0.3 0.4 1.7 -0.5 -0.4 -0.6 0.2 -0.1 1.3
Primary Biliary Cirrhosis 0.3 0.5 1.9 -0.1 -0.5 0.2 0.1 -0.8 1.4
Rheumatoid Arthritis 0.6 0.8 4.5 0.6 0.2 0.3 -0.0 0.0 2.1
Schizophrenia (2014) 11.2 24.7 42.1 3.0 6.1 4.7 1.9 5.8 -6.5
Triglycerides 0.2 0.3 0.7 -0.9 -0.7 -0.2 0.4 -0.4 -0.0
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.8 0.1 -0.1 0.5 -1.7 -0.7 1.0
Ulcerative Colitis 0.1 0.2 0.3 0.5 0.2 -0.4 -0.6 -0.3 -0.4
Blood Eosinophil Count 0.7 5.3 13.8 -0.1 1.0 1.0 3.2 2.4 -3.7
Blood Platelet Count 0.6 6.8 24.2 0.6 -1.4 -1.3 -2.9 -2.0 4.9
Blood Red Count 0.3 3.2 13.2 -0.3 0.1 -0.2 3.6 0.6 -2.3
Blood White Count 0.2 1.2 2.7 1.1 1.1 1.1 0.0 0.7 -1.6
Heel T-Score 6.8 54.0 112.4 9.3 10.6 7.8 -3.0 7.2 -1.6
BMI 0.3 1.7 2.7 -1.6 -1.0 0.0 1.6 -1.2 -1.6
Height 4.1 78.4 127.7 3.7 7.6 7.2 11.3 10.2 -10.7
Waist Hip Ratio (WHR) 0.5 2.4 5.8 -1.5 -1.3 -2.4 -0.5 -1.4 1.5
Systolic Blood Pressure 0.2 0.9 2.4 0.5 1.6 0.1 1.0 0.9 -0.9
Smoking Status 1.9 4.6 6.6 2.0 2.5 2.3 1.7 2.6 -1.5
Allergy or Eczema 0.3 0.7 1.8 -0.4 -0.6 1.3 -0.6 0.0 1.2
Cardiovascular Disease 0.3 1.0 3.5 0.8 1.9 -0.1 0.4 1.0 -0.9
Hypothyroidism (self reported) 0.2 0.4 1.6 -0.3 -0.5 -0.0 1.2 -0.6 0.3
Respiratory disease 0.9 2.0 2.7 1.4 1.5 1.4 1.0 1.5 -1.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.0 1.0 0.8 -0.6 -1.7 0.5 1.2
Lung FEV1/FVC ratio 0.6 3.2 7.7 -2.1 -2.4 -2.8 0.5 -0.8 0.9
Lung FVC 0.9 4.7 12.1 0.1 -1.5 -0.4 -3.5 -2.6 2.6
Neuroticism 0.7 1.7 4.5 0.8 1.4 0.1 1.7 2.1 -0.0
Chronotype (morning person) 2.6 6.0 11.6 -1.5 -3.0 -1.6 -2.2 -2.5 3.4
Hair Pigment 0.3 8.8 29.6 0.0 1.3 0.8 5.4 2.9 -3.5
Tanning 0.1 1.4 4.9 1.1 0.5 -0.9 -0.6 0.9 2.2
Hand grip strength (left) 0.7 1.8 3.8 0.1 0.7 1.1 1.9 1.4 -1.8
Number of treatments/medications taken 0.4 0.6 1.5 -0.5 0.8 1.2 0.0 0.1 -1.2
Average weekly spirits intake 1.9 2.3 6.8 0.2 1.1 1.5 2.6 1.3 -1.6
Sensitivity / hurt feelings 0.8 1.3 4.0 -0.6 0.2 -0.2 2.0 1.8 0.4
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.7 1.3 0.8 0.3 -1.5 0.6 1.6
Hearing difficulty/problems: Yes 1.9 3.0 9.0 -1.6 -0.2 0.0 3.0 1.1 -2.3
Relative age of first facial hair 0.7 1.4 2.9 1.1 1.7 1.6 -0.6 1.2 0.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.8 0.8 1.4 1.7 0.7 1.2 -1.3
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.1 -0.4 -0.2 -0.9 -0.4 -0.3 1.4
Ever had hysterectomy (womb removed) 0.8 0.9 2.1 1.4 0.9 0.5 0.1 1.2 0.7
Systolic blood pressure, automated reading 0.2 0.6 1.4 0.3 0.9 0.7 1.2 0.2 -0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.0 1.4 0.7 -0.0 0.1 0.7 -0.3
Angina 1.0 1.4 5.5 -0.5 -0.7 0.3 -2.3 -1.0 0.9
Medication for hormone replacement therapy 0.7 0.8 2.0 -0.5 -1.1 -1.4 -0.4 -0.4 0.9
Vitamin and mineral supplements 0.0 0.0 0.1 0.0 -0.1 0.2 -0.4 0.1 0.2
Supplements: Zinc 1.2 1.3 2.7 0.8 1.6 1.3 -0.0 1.4 -0.9
Medication: Co-codamol 1.6 1.8 3.2 1.1 1.7 1.8 -0.4 1.7 -0.7
Medication: Metformin 0.7 1.0 2.8 1.1 1.0 -0.5 -1.7 0.5 0.6
Diabetes (father) 0.6 0.8 1.4 -0.9 -0.9 -1.1 0.2 -0.5 1.2
Diabetes (mother) 0.3 0.4 1.0 0.5 0.2 0.3 -0.9 -0.3 1.0
Severe depression (siblings) 0.1 0.1 0.3 -0.2 0.6 0.0 -0.1 -0.2 -0.1
Pack years adult smoking proportion 0.7 1.1 3.5 0.9 0.9 -0.5 -1.9 0.3 1.0
Impedance of leg (right) 1.4 6.7 21.1 2.2 1.1 0.9 -3.5 0.4 4.6
Leg fat-free mass (left) 2.9 15.5 42.5 0.9 2.7 3.2 4.7 3.1 -6.5
Trunk fat percentage 0.2 0.8 2.7 0.7 1.0 1.6 0.3 0.1 -0.5
Hand grip strength (right) 1.4 3.7 6.3 0.4 1.2 2.4 2.5 1.6 -2.5
Townsend deprivation index at recruitment 1.1 1.6 4.9 0.8 0.5 -0.7 -2.2 -0.1 1.8
Current tobacco smoking 0.7 1.1 1.9 1.2 1.4 0.3 0.2 1.4 1.0
Average weekly fortified wine intake 2.3 2.7 7.8 -1.8 -0.9 -1.6 2.8 0.2 -1.3
Maternal smoking around birth 0.3 0.5 1.6 0.1 -0.1 1.3 1.0 -0.1 -0.5
Fed-up feelings 0.2 0.3 1.1 -0.0 0.2 0.3 0.4 0.6 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 3.1 1.8 1.5 0.3 -1.6 1.1 1.3
Relative age voice broke 1.5 2.4 4.7 1.8 2.2 1.1 0.8 2.0 -0.5
Taking other prescription medications 0.3 0.4 1.5 -1.2 -0.2 0.2 0.4 -0.3 -0.7
Age when periods started (menarche) 0.3 0.7 2.1 -0.0 0.5 0.3 1.2 1.5 0.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 4.7 0.1 -0.5 -2.2 -0.5 -0.4 1.5
Heel bone mineral density (BMD) T-score, automated (left) 4.9 11.2 23.6 3.5 4.9 3.5 0.3 4.2 -0.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 -0.1 0.4 1.0 0.1 0.5 -0.8
Qualifications: CSEs or equivalent 0.1 0.1 0.4 0.5 0.2 -0.6 0.0 -0.3 0.2
Serious illness, injury or assault to yourself 1.1 1.4 2.4 1.3 1.6 1.5 -1.0 1.0 -0.3
High blood pressure 0.7 1.9 4.1 1.2 1.9 0.5 0.6 1.3 -2.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.8 -0.8 -0.7 1.3 -0.6 -0.2 0.3
Multivitamins +/- minerals 0.2 0.3 0.7 -0.4 -0.3 -0.1 -0.9 -0.4 0.7
Stomach or abdominal pain in last month 0.2 0.2 0.5 0.5 0.7 0.3 0.7 0.2 0.3
Supplements: Glucosamine 2.1 2.8 5.8 1.7 1.9 1.4 0.0 2.4 1.5
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 4.5 -2.1 -1.8 -1.0 -0.3 -2.0 -0.8
Medication: Atenolol 1.9 2.4 5.5 -1.4 -1.3 -2.3 -1.5 -1.7 0.1
Medication: Levothyroxine sodium 0.3 0.5 2.1 -0.5 -0.6 -1.5 0.3 -0.2 0.6
Sitting height 8.7 61.5 92.4 4.1 7.2 7.3 8.4 9.1 -9.6
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 -0.0 -0.0 -0.8 1.3 0.4 -1.0
High blood pressure (mother) 1.2 1.6 3.1 1.5 1.8 1.3 0.3 1.6 -0.3
Body mass index (BMI) 0.1 0.3 0.9 -0.1 0.1 0.9 0.3 -0.5 -0.7
Impedance of leg (left) 1.0 4.8 18.5 1.4 0.7 0.1 -2.8 0.2 4.3
Leg predicted mass (left) 2.8 15.0 41.3 0.9 2.7 3.2 4.6 3.1 -6.4
Trunk fat mass 0.8 3.6 6.3 0.9 1.9 2.4 1.8 1.3 -2.5
Waist circumference 0.6 2.0 5.7 -0.1 0.9 1.2 2.0 0.6 -2.4
Number of incorrect matches in round 0.7 1.2 6.6 -0.3 -0.2 -2.6 -0.4 -0.6 -0.0
Past tobacco smoking 2.0 3.6 6.2 -1.4 -1.9 -1.9 -1.3 -2.1 2.5
Alcohol usually taken with meals 1.8 3.0 7.8 -1.5 -0.3 -0.2 2.8 -0.1 -2.8
Nervous feelings 0.2 0.4 1.3 0.1 0.6 1.1 0.5 0.6 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 7.6 1.8 1.0 0.5 -2.8 0.6 2.2
Hearing difficulty/problems with background noise 0.6 1.0 3.0 -0.6 0.2 0.7 1.7 1.1 -1.0
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 0.6 0.4 0.9 -0.4 -0.4 -0.5
Had menopause 0.2 0.2 0.6 0.8 0.7 0.4 -0.3 0.3 -0.0
Had other major operations 1.3 1.6 2.2 -1.2 -1.4 -1.5 1.2 -0.9 -1.2
Forced vital capacity (FVC) 0.7 2.8 9.1 2.1 1.2 3.0 -0.3 0.6 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 5.1 11.6 25.3 3.8 5.0 3.0 0.4 4.5 -0.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.1 -0.1 0.6 1.1 -0.3 0.1 -0.5
Qualifications: None of the above 1.1 2.4 5.2 -0.6 -0.9 -1.4 -2.0 -1.3 2.3
Financial difficulties in last 2 years 0.8 1.1 2.9 0.1 0.3 1.7 -1.4 -0.9 0.8
Mouth/teeth dental problems 0.4 0.6 1.7 0.9 0.7 1.3 0.0 0.9 -0.1
Heart attack 0.8 1.0 1.6 1.0 1.0 1.3 -1.1 1.1 0.3
Allergy 0.1 0.3 1.0 0.5 0.3 -1.0 0.5 -0.2 -0.2
Pain all over the body in last month 1.3 1.4 4.8 0.0 -0.6 0.4 -2.2 -1.4 1.0
Diabetes (self-reported) 0.6 1.0 2.8 0.1 0.2 -1.7 -0.9 0.1 1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.3 -0.5 -0.6 1.5 0.3 -0.3 -0.2
Medication: Ramipril 1.6 2.0 4.1 1.6 2.0 2.0 -0.4 1.1 -0.1
Medication: Simvastatin 0.4 0.6 1.2 0.4 0.9 -1.0 0.6 1.1 -0.4
Fluid intelligence score 0.2 0.4 1.2 -0.4 -0.7 -1.1 0.5 -0.3 -0.6
Illnesses of siblings 2.6 3.6 7.8 -1.0 -2.2 -2.8 -1.1 -2.5 0.5
Neuroticism score 0.5 1.0 3.1 0.0 0.7 0.0 1.5 1.8 -0.1
Weight 2.1 10.2 20.5 1.2 2.7 3.3 3.7 2.8 -4.5
Impedance of arm (right) 0.6 2.9 9.0 0.8 -0.4 -0.1 -3.0 -1.2 2.5
Arm fat percentage (right) 0.2 0.9 2.5 0.5 0.3 1.2 -1.6 -0.9 0.5
Trunk fat-free mass 4.1 23.3 47.7 1.7 3.9 4.1 5.7 5.0 -6.9
Hip circumference 1.4 6.2 13.3 1.1 1.9 2.8 2.7 1.9 -3.6
Time employed in main current job 0.2 0.3 0.6 -0.4 0.5 0.6 -0.8 -0.4 -0.2
Alcohol intake versus 10 years previously 0.9 1.3 2.5 -0.1 -1.2 -1.0 -1.6 -0.8 1.4
Father’s age at death 1.2 1.7 8.1 0.2 0.1 0.0 2.8 0.8 -1.0
Worrier / anxious feelings 1.0 2.0 4.0 -2.0 -1.6 -2.0 0.9 -0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 6.5 0.9 0.6 0.8 -2.2 -0.0 2.5
Falls in the last year 0.4 0.6 1.2 -0.6 -0.3 -0.8 -1.0 -1.1 0.2
Hair/balding pattern: Pattern 3 1.7 2.6 4.7 -2.2 -1.0 -1.5 2.1 -0.0 -1.7
Number of live births 0.2 0.3 0.8 0.9 0.4 0.9 -0.2 -0.0 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.9 0.7 -0.3 1.4 -0.4 -0.4 -0.4
Pulse rate 1.7 2.8 6.2 1.8 2.5 1.8 0.9 1.5 -1.1
Happiness 0.3 0.4 1.8 0.3 0.3 0.5 -1.3 -0.2 0.5
Noisy workplace 0.5 0.6 1.8 -0.5 0.2 0.1 -1.4 -0.3 1.1
Qualifications: A levels/AS levels or equivalent 2.8 6.3 17.5 -0.3 0.7 0.8 4.2 1.9 -3.9
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.0 -1.0 -0.6 -0.6 0.1 -1.4 0.2
Mouth/teeth dental problems: Dentures 1.4 2.4 7.6 -0.1 -1.1 -1.6 -1.4 -1.0 2.8
Asthma 0.4 0.7 1.2 0.9 0.9 1.1 -1.1 0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.2 -1.8 -1.3 -1.4 -0.3 -0.9 1.1
Medication: Cholesterol lowering 0.2 0.4 1.0 -0.4 -0.0 -0.3 -1.0 -0.3 0.9
Depression (self-reported) 0.3 0.4 1.0 0.1 -0.2 -0.9 -1.0 -0.2 0.6
Medication: Lansoprazole 0.2 0.2 0.4 -0.5 -0.5 0.5 0.4 -0.6 0.1
Prospective memory result 1.8 2.2 9.1 0.7 1.5 3.0 -0.2 0.3 -1.0
Lung cancer (father) 0.5 0.5 2.7 0.0 0.2 1.6 0.4 -0.0 -0.5
Illnesses of mother 0.6 0.8 1.9 -1.3 -0.7 -1.4 0.2 -0.2 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.1 0.5 -0.0 0.5 -0.0 -0.2 -1.1
Pulse wave Arterial Stiffness index 1.3 1.5 5.1 1.1 1.2 2.2 -0.7 0.2 -0.8
Impedance of arm (left) 0.4 2.1 5.6 0.8 -0.4 -0.1 -2.2 -1.1 2.4
Arm fat mass (right) 0.6 2.4 5.8 1.2 1.7 2.4 0.5 1.1 -1.7
Trunk predicted mass 4.1 23.4 47.3 1.8 3.9 4.1 5.7 5.0 -6.9
Standing height 4.0 40.1 67.2 2.9 5.5 5.2 7.6 7.1 -8.2
Length of working week for main job 0.7 0.8 3.5 -0.1 -0.2 0.1 -1.0 -0.3 1.9
Exposure to tobacco smoke at home 0.6 0.7 2.1 0.4 1.3 0.4 -1.4 0.2 -0.3
Breastfed as a baby 0.5 0.6 1.6 0.9 0.7 1.2 0.6 0.3 -0.5
Tense / ‘highly strung’ 1.4 2.4 5.2 2.1 2.3 1.0 0.2 1.9 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.2 -0.1 -0.3 0.3 -1.5 -0.5 2.0
Hair/balding pattern: Pattern 4 0.5 1.2 3.9 0.8 -0.1 -0.3 -2.0 -0.7 1.5
Birth weight of first child 0.7 1.4 4.8 0.0 0.6 -0.3 2.2 1.5 -0.8
Peak expiratory flow (PEF) 0.8 1.9 4.2 -1.3 -2.1 -0.9 1.7 -1.3 0.1
Pulse wave reflection index 2.1 2.6 6.6 1.8 1.6 2.6 0.2 1.8 0.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.6 -0.3 0.4 1.4 0.7 0.6 -1.6
Loud music exposure frequency 0.3 0.3 0.8 -0.2 -0.6 -0.7 0.9 -0.3 -0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.4 -0.2 -0.7 0.4 2.3 0.7 -1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.5 -1.1 -0.3 0.0 0.7 -0.3 -1.6
Blood clot in the leg (DVT) 2.2 2.8 7.1 -0.9 -2.7 -2.0 0.8 -1.6 1.2
Medication: Paracetamol 0.5 0.9 2.2 -1.5 -1.2 0.2 -0.6 -1.1 0.1
Headache pain in last month 1.0 1.7 3.2 0.9 1.2 1.5 1.8 1.4 0.7
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.4 -0.4 0.2 0.1 0.1 0.0
Glaucoma (self-reported) 0.7 0.9 4.2 -0.0 -0.8 -2.0 0.4 -0.2 0.5
Gout (self-reported) 2.1 2.9 5.9 0.3 1.4 1.5 2.4 1.5 -2.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.3 -1.1 -0.9 -0.6 1.2 -0.7 0.0
Medication: Amlodipine 0.2 0.2 1.0 -0.5 0.4 -0.1 -0.2 0.1 -1.0
Medication: Ventolin 100micrograms inhaler 2.7 3.5 10.1 1.5 2.4 3.2 -0.9 0.6 -1.3
Birth weight 0.4 0.9 1.5 1.0 0.8 0.4 1.1 1.2 -0.9
Chronic bronchitis/emphysema (mother) 1.8 2.1 9.0 1.3 1.3 3.0 -0.2 0.3 -0.5
High blood pressure (siblings) 3.1 4.5 10.3 1.4 1.9 3.2 2.0 2.6 0.2
Forced vital capacity (FVC), Best measure 0.5 1.9 3.8 1.7 1.2 1.9 0.2 0.6 -1.7
Body fat percentage 0.2 0.7 2.7 0.7 0.9 1.6 -0.4 -0.2 0.0
Leg fat percentage (right) 0.4 1.5 3.7 1.3 1.0 1.9 -1.2 -0.2 1.1
Arm fat-free mass (right) 4.1 21.0 43.7 1.7 3.7 3.7 5.5 4.7 -6.6
Exposure to tobacco smoke outside home 1.5 2.0 4.3 1.1 2.0 1.4 0.6 2.1 0.3
Comparative body size at age 10 0.5 1.5 6.0 0.8 0.2 0.9 -2.4 -0.5 1.2
Number of full brothers 0.4 0.5 1.3 0.5 1.1 0.5 0.2 0.9 0.4
Worry too long after embarrassment 0.6 1.0 4.1 -0.8 -1.0 -0.5 2.0 -0.1 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.3 1.5 2.0 0.5 -0.4 2.1 -0.0
Wheeze or whistling in the chest in last year 1.3 2.3 6.1 0.1 1.5 1.1 1.6 1.3 -2.5
Number of children fathered 1.9 2.2 10.4 1.3 0.6 3.2 0.4 0.5 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 5.0 -0.7 -1.9 -2.2 0.2 -1.1 1.3
Age at first live birth 1.5 2.6 11.7 -1.2 -0.0 0.3 1.6 0.1 -3.4
Pulse wave peak to peak time 0.7 0.8 2.4 -0.7 -0.6 -1.5 1.2 0.5 0.3
Health satisfaction 0.4 0.5 1.0 0.1 -0.4 0.5 -0.9 -0.7 1.0
Shortness of breath walking on level ground 0.2 0.2 0.7 0.2 0.2 0.1 -0.9 -0.2 -0.6
Qualifications: College or University degree 3.4 10.7 26.4 1.2 3.1 2.9 2.7 3.3 -5.1
Eye problems/disorders: None of the above 0.6 0.7 1.7 -1.3 -0.9 -0.2 -0.4 -1.1 0.1
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.2 0.5 0.5 0.9 1.3 -0.0 -1.5
Emphysema/chronic bronchitis 2.0 2.2 4.9 1.1 2.0 2.2 -0.5 1.6 -0.6
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 0.8 0.1 0.1 -0.1 0.5 0.6
Neck or shoulder pain in last month 1.3 1.8 5.9 0.2 0.2 -0.2 -2.4 0.3 2.1
Medication: Blood pressure 0.1 0.1 0.4 -0.5 0.2 -0.2 -0.2 -0.2 -0.6
Angina (self-reported) 1.4 1.9 7.3 -0.5 -0.9 0.0 -2.7 -1.2 1.2
Migraine (self-reported) 1.9 2.4 4.2 -1.4 -2.0 -2.1 0.7 -1.7 1.1
Medication: Ibuprofen 1.3 1.6 2.8 -1.6 -1.0 -1.5 -0.4 -0.9 1.7
Medication: Allopurinol 2.9 3.9 6.2 1.8 2.2 2.5 1.5 2.0 -1.7
Medication: Omeprazole 0.8 1.0 2.6 -0.7 -0.6 -0.4 -1.6 -1.3 0.8
Medication: Seretide 50 evohaler 0.6 0.7 2.1 1.0 0.4 -0.2 1.5 1.1 0.0
Mean time to correctly identify matches 3.8 7.2 14.3 1.5 3.6 3.8 -0.8 2.5 -2.5
Heart disease (mother) 0.1 0.1 0.3 0.3 0.1 0.1 -0.5 -0.5 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.1 -1.5 -1.3 -1.0 0.9 -0.8 0.7
Whole body fat mass 0.8 3.5 5.9 0.9 2.0 2.4 1.6 1.5 -2.4
Leg fat mass (right) 0.6 2.5 5.8 1.2 1.9 2.4 0.9 1.2 -1.5
Arm predicted mass (right) 3.8 19.3 41.0 1.6 3.6 3.7 5.2 4.3 -6.4
Pulse rate, automated reading 2.6 8.4 12.4 1.9 3.1 2.8 2.8 3.1 -3.5
Alcohol intake frequency. 3.1 7.2 13.6 -1.2 -2.8 -1.6 -3.1 -3.7 2.9
Comparative height size at age 10 3.0 16.3 27.4 1.7 2.9 3.5 5.2 4.4 -5.2
Number of full sisters 3.6 4.4 8.3 2.3 1.8 2.9 -2.3 0.9 1.8
Suffer from ‘nerves’ 1.0 1.5 4.5 -0.1 1.0 0.6 1.4 2.1 -1.1
Overall health rating 0.7 1.4 2.4 1.4 1.6 1.3 -1.0 1.2 -0.1
Chest pain or discomfort 1.3 1.9 5.6 0.6 1.5 0.1 1.4 2.4 -1.0
Had major operations 2.0 2.4 4.7 1.8 2.1 2.2 -0.6 1.2 -0.4
Age at last live birth 0.9 1.4 6.1 0.1 0.7 1.2 -0.1 -0.2 -2.5
Family relationship satisfaction 1.4 1.7 4.6 1.1 1.6 2.1 -0.2 1.2 0.1
Leg pain on walking 0.4 0.5 1.3 0.3 1.1 0.6 -1.1 0.3 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.4 -0.7 -1.1 -0.9 -0.1 -1.2 0.9
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 0.3 0.4 0.7 -0.5 0.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.7 -0.2 0.0 -0.3 -0.1 0.5 -0.9
Medication: Aspirin 1.0 1.3 4.5 0.1 0.9 -0.6 1.3 0.9 -2.1
Supplements: Vitamin C 0.9 1.1 3.4 -0.7 0.3 -0.5 1.9 0.7 -1.3
Knee pain experienced in last month 0.9 1.3 3.7 0.7 1.0 1.4 1.0 1.9 0.1
Hypertension (Self-reported) 0.5 1.5 3.4 0.9 1.7 -0.0 0.6 1.2 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 5.3 0.6 0.9 2.3 -0.6 0.6 0.1
Illnesses of father: Heart disease 1.9 2.7 7.3 1.9 1.7 1.4 -2.7 -0.0 0.6
Illnesses of siblings: Diabetes 0.6 0.7 2.5 -0.1 1.0 0.5 0.0 1.6 -0.6
Smoking status: Previous 1.3 1.9 5.4 0.7 1.0 1.6 0.8 1.2 -2.3
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.2 12.1 0.8 1.5 1.7 3.5 2.2 -3.0
Whole body fat-free mass 3.8 21.7 50.7 1.3 3.5 3.7 5.7 4.4 -7.1
Leg fat-free mass (right) 3.0 15.8 46.1 0.3 2.4 2.6 5.2 3.0 -6.8
Arm fat percentage (left) 0.2 0.7 1.6 0.4 0.2 1.2 -1.3 -1.1 0.4
Average weekly red wine intake 0.8 1.1 2.9 0.8 0.6 0.1 0.7 1.7 1.6
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 0.2 0.2 -0.5 -0.4 -0.1 0.2
Mood swings 1.0 1.8 4.4 1.4 1.3 0.5 -0.6 1.4 2.1
Loneliness, isolation 0.4 0.5 1.4 0.8 1.0 0.0 -0.5 1.2 0.1
Long-standing illness, disability or infirmity 0.6 0.9 1.8 0.8 1.4 1.1 -0.7 1.1 -0.3
Ever had bowel cancer screening 2.9 3.4 7.2 -2.7 -1.6 -1.6 2.2 -1.1 -1.4
Diabetes diagnosed by doctor 0.7 1.1 2.7 0.5 1.1 -0.9 -1.7 0.6 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 0.3 0.0 0.2 -0.1 -0.7 -0.1
Friendships satisfaction 1.1 1.3 2.5 1.2 1.6 1.5 -0.1 1.2 -0.6
Qualifications: nursing, teaching 1.1 1.7 5.4 -0.8 0.2 -0.1 1.9 0.6 -2.3
Commuting to job workplace: Walk 0.6 0.7 2.0 0.2 0.3 0.4 1.4 1.3 -0.2
Eye problems/disorders: Cataract 0.5 0.6 1.9 0.7 0.9 0.0 -1.4 0.5 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 -0.2 0.1 -0.4 0.9 0.7 -0.7
Medication for cholesterol 0.6 0.9 4.1 0.1 0.8 2.0 -0.2 0.6 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.6 0.2 0.1 1.3 0.5 0.1 -0.8
Back pain experienced in last month 0.4 0.7 2.1 -0.9 -1.5 0.0 0.3 -0.4 0.8
Mineral and other dietary supplements 1.2 1.7 3.8 -1.3 -1.6 -1.1 0.6 -1.9 -0.2
Breast cancer (self-reported) 1.1 1.3 3.6 0.9 1.3 1.0 -1.9 0.6 -0.6
Asthma (self-reported) 0.5 1.0 2.2 1.1 1.1 1.5 -0.9 0.6 -0.6
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.4 -0.5 -1.0 -0.5 -0.4 1.0
Osteoarthritis (self-reported) 0.4 0.5 1.4 -0.3 -0.3 -1.1 -0.3 0.2 1.2
Medication: Aspirin 1.0 1.3 4.5 -0.2 0.8 -0.8 1.2 0.8 -2.1
Medication: Gliclazide 0.2 0.3 0.5 0.7 0.7 -0.2 -0.3 0.5 0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.8 -0.9 -0.6 -0.2 0.5 -0.2 0.0
Smoking status: Current 1.3 2.1 4.1 1.6 2.0 1.0 0.8 2.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 3.9 7.3 -1.8 -2.2 -0.9 -1.6 -2.7 2.1
Whole body water mass 3.8 21.9 49.8 1.6 3.7 3.9 5.5 4.5 -7.1
Leg predicted mass (right) 3.0 16.0 46.2 0.3 2.4 2.6 5.2 3.1 -6.8
Arm fat mass (left) 0.6 2.4 5.4 1.1 1.6 2.3 1.0 1.0 -1.9
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 -0.9 -0.8 -0.6 0.8 -0.3 0.5
Average weekly champagne plus white wine intake 3.4 4.7 12.0 -0.1 1.5 1.2 3.2 1.4 -3.5
Miserableness 2.4 4.2 9.8 1.5 2.5 1.4 2.0 3.1 -0.8
Guilty feelings 0.2 0.2 1.1 -0.4 0.2 0.1 0.2 0.2 1.0
Wears glasses or contact lenses 0.8 0.9 1.7 1.3 1.2 0.6 0.9 1.1 -0.1
Ever taken oral contraceptive pill 0.6 0.7 1.7 -1.0 -0.7 -0.6 -0.5 -1.3 0.1
Hearing aid user 1.1 1.3 2.5 -1.4 -1.4 0.6 1.6 -0.8 -0.6
Mother’s age at death 1.4 1.8 6.9 0.3 0.8 0.5 2.6 1.3 -1.1
Financial situation satisfaction 1.6 1.9 3.8 -0.9 -1.4 -0.9 -1.6 -1.4 1.9
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.5 -1.3 -1.5 -1.6 1.3 -0.7 -0.3
Commuting to job workplace: Public transport 0.7 0.8 3.4 -0.3 -0.2 0.4 1.8 0.3 -1.1
Eye problems/disorders: Glaucoma 0.8 1.0 3.7 0.2 -0.8 -1.9 0.7 -0.2 0.9
Medication: Blood pressure 1.0 1.8 3.7 1.6 1.9 0.5 0.1 1.6 -1.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.6 -0.2 0.2 -0.1 -1.6 -0.3 0.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.4 0.8 1.1 0.1 0.4 1.8 -0.0
High cholesterol (Self-reported) 0.2 0.3 0.8 0.4 0.1 -0.2 0.8 0.9 0.3
Medication: Bendroflumethiazide 1.6 2.5 5.7 -1.8 -1.8 -2.4 -0.3 -1.6 -0.2
Medication: Paracetamol 0.2 0.3 1.1 -1.1 -0.4 0.2 -0.2 -0.5 0.1
Medication: Lisinopril 1.2 1.5 6.9 0.7 0.3 0.1 -2.6 -1.2 -0.0
Medication: Atorvastatin 0.5 0.6 1.2 -0.5 0.7 0.9 -0.3 0.9 -1.1
Illnesses of father: High blood pressure 0.5 0.6 3.1 -0.1 0.6 -0.0 -0.2 0.6 -1.8
Alcohol drinker status: Never 1.6 1.9 3.7 -1.2 -1.2 -1.9 -0.8 -1.7 1.2
Ever smoked 2.3 4.0 6.6 2.3 2.4 1.2 1.3 2.6 -1.8
Basal metabolic rate 3.5 19.6 44.1 1.4 3.5 3.8 5.2 4.2 -6.6
Leg fat percentage (left) 0.2 0.7 2.1 0.6 0.6 1.5 -0.7 -0.4 0.9
Arm fat-free mass (left) 4.1 20.7 40.8 1.9 3.9 4.0 5.1 4.7 -6.4
Number of operations (self-reported) 0.2 0.3 0.7 0.1 -0.3 0.8 -0.0 -0.7 -0.7
Average weekly beer plus cider intake 0.6 0.9 1.5 0.8 1.2 0.3 -0.9 1.2 0.9
Irritability 1.0 1.8 5.6 1.2 1.7 0.8 -0.0 2.4 0.3
Risk taking 0.3 0.4 0.8 0.9 0.7 0.7 -0.7 0.7 0.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.1 -0.4 1.1 1.1 1.8 1.0 -0.5
Fractured/broken bones in last 5 years 1.9 2.4 4.0 -2.0 -1.9 -1.8 -0.7 -1.6 -0.5
Age started oral contraceptive pill 1.4 1.8 8.4 -0.4 0.5 0.0 1.2 0.6 -2.9
Diastolic blood pressure, automated reading 0.2 0.7 1.6 0.3 0.8 0.8 1.3 0.8 -0.7
Ever depressed for a whole week 0.2 0.3 1.0 -0.5 0.3 0.5 0.1 -0.3 -1.0
Unable to work because of sickness or disability 1.5 1.9 3.9 1.6 0.7 1.3 -2.0 -0.4 1.7
Commuting to job workplace: Cycle 0.9 1.1 4.0 0.4 0.0 1.2 -0.2 -0.9 -2.0
Myopia 0.4 0.5 1.0 -0.7 -0.8 0.3 -0.4 -1.0 0.9
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.1 -0.8 -1.3 -0.5 0.3 -0.9 1.4
Cholesterol lowering medication 0.2 0.3 0.8 0.8 -0.1 -0.9 0.4 0.2 0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -1.0 -0.8 -0.0 -0.3 -0.7 0.6
Pain experienced in last month 0.2 0.3 0.7 0.3 0.1 -0.5 -0.8 -0.4 -0.8
Supplements: Calcium 0.4 0.5 0.8 0.7 0.8 0.9 -0.1 0.5 -0.9
Basal cell carcinoma (self-reported) 2.1 2.5 4.4 1.8 2.1 2.0 -1.1 1.5 -0.2
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 0.8 0.8 0.8 -0.7 1.0 0.2
Deep venous thrombosis (DVT) (self-reported) 2.3 3.0 7.3 -1.0 -2.7 -2.2 0.6 -1.7 1.3
Heart disease (siblings) 0.3 0.4 1.4 -0.8 -0.4 -1.2 -0.1 0.5 0.1
Alcohol drinker status: Previous 3.8 4.4 11.7 -1.8 -1.4 -0.8 -3.4 -2.3 1.9
Pack years of smoking 0.4 0.6 2.5 0.2 0.3 -0.6 -1.6 -0.2 0.7
Impedance of whole body 0.7 3.4 12.9 0.7 -0.1 -0.2 -2.6 -0.6 3.6
Leg fat mass (left) 0.6 2.2 4.8 0.9 1.7 2.2 1.0 1.1 -1.5
Arm predicted mass (left) 3.6 18.3 35.6 1.7 3.6 3.8 4.8 4.5 -6.0