Hub : Genes

KCNJ13

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.071	0.043	1.3e-03	0.063	0.051	0.054	NA	0.052	1.7e-04	6.7e-04	0.00047	NA	0.00063
2	TCGA	Pancreatic Adenocarcinoma	0.075	0.042	2.3e-03	0.072	0.055	0.025	NA	0.052	6.0e-04	2.4e-03	0.03100	NA	0.00330
3	TCGA	Stomach Adenocarcinoma	0.088	0.043	2.5e-05	0.063	0.076	0.046	NA	0.051	2.6e-05	3.7e-06	0.00027	NA	0.00013
4	TCGA	Thyroid Carcinoma	0.033	0.023	6.5e-03	0.000	0.009	0.007	NA	-0.001	3.0e-01	4.3e-02	0.06500	NA	0.49000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.3	2.1	7.5	-0.2	0.8	0.3	-2.7
Bipolar Disorder or Schizophrenia	3.7	9.0	28.3	0.4	2.4	1.4	-5.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.2	0.3	0.5	0.2
Depression (Nagel 2018)	1.2	1.8	3.0	-1.7	-1.2	-0.9	1.3
Intelligence (Savage-Jansen 2018)	4.1	12.5	16.9	3.6	3.5	2.8	-4.1
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.8	0.8	0.9	-0.1
Schizophrenia (2018)	3.6	7.5	21.5	0.7	2.4	1.6	-4.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.5	0.0	-0.1	-0.8
Worry (Nagel 2018)	0.3	0.7	1.9	1.4	0.6	0.4	-0.5
Alzheimer’s Disease (in mother)	2.0	2.3	4.6	1.4	1.7	2.1	-0.2
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.5	-0.8	-0.3	1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	0.2	0.3	0.9	1.3
Crohns Disease (2017)	0.4	0.8	1.1	-0.9	-1.0	-1.0	0.6
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.3	-0.4	-0.4	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.4	0.5	0.7	-0.3
Major Depression (MDD)	0.5	0.6	1.4	-0.9	-0.5	-0.2	1.2
Reaction Time	1.2	2.3	4.3	-2.1	-0.9	-1.3	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.3	3.6	1.4	1.4	1.2	-1.9
Breast Cancer	0.3	0.7	1.1	0.9	0.8	1.0	0.4
Ovarian Cancer	1.3	1.7	2.2	1.1	1.5	1.5	-1.1
Prostate Cancer	1.4	2.0	4.5	1.2	1.3	0.6	-2.1
Age at First Birth	1.4	2.0	2.6	1.6	1.4	1.2	-1.4
Bipolar Disorder (2011)	2.9	2.8	6.3	0.7	1.6	1.3	-2.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	0.1	0.6	0.4	-1.4
Coronary Artery Disease (CAD)	4.4	5.2	8.6	-2.9	-2.3	-2.1	1.6
Crohns Disease (2012)	0.9	1.4	2.0	-1.1	-1.4	-1.4	0.7
Mean Putamen Volume	0.8	0.9	1.5	-1.2	-1.0	-0.6	0.9
Fasting Glucose	0.2	0.3	0.4	-0.5	0.5	0.7	-0.3
HbA1C	0.3	0.4	0.9	-1.0	-0.3	-0.2	0.7
HDL Cholesterol	0.2	0.4	1.3	0.5	0.2	-0.1	-1.1
LDL Cholesterol	1.2	1.9	3.5	1.3	1.3	0.9	-1.9
Lupus	3.1	4.6	7.6	1.7	2.2	1.8	-2.8
Neuroticism (2016)	0.3	0.5	0.8	0.5	0.6	0.9	0.7
Primary Biliary Cirrhosis	0.6	0.8	1.6	-1.0	-0.6	-0.5	1.3
Rheumatoid Arthritis	0.8	1.1	2.5	-0.8	-0.9	-0.8	1.6
Schizophrenia (2014)	5.7	12.5	37.0	1.1	2.9	1.9	-6.1
Triglycerides	0.2	0.3	0.7	-0.5	-0.5	-0.8	-0.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.3	-1.8	-1.6	-1.3	1.4
Ulcerative Colitis	0.0	0.0	0.0	0.1	0.0	0.0	-0.2
Blood Eosinophil Count	1.9	14.7	16.0	3.7	4.0	3.7	-3.9
Blood Platelet Count	0.5	6.0	16.0	-2.4	-1.5	-0.4	4.0
Blood Red Count	0.6	5.6	6.6	2.6	2.4	1.9	-2.6
Blood White Count	0.3	2.5	3.6	0.5	1.7	1.7	-1.9
Heel T-Score	0.5	3.9	12.2	-3.5	-0.5	-0.4	-1.7
BMI	0.1	0.8	1.5	1.2	0.6	0.2	-1.1
Height	6.9	132.0	146.4	10.7	12.0	11.1	-12.1
Waist Hip Ratio (WHR)	0.7	3.2	4.4	-1.0	-2.0	-1.9	2.1
Systolic Blood Pressure	0.1	0.7	1.7	-0.4	-0.8	-1.3	-0.4
Smoking Status	1.0	2.4	3.1	0.8	1.7	1.8	-1.6
Allergy or Eczema	0.1	0.3	0.9	-0.5	-0.0	0.3	0.9
Cardiovascular Disease	0.7	2.2	5.0	-0.8	-1.8	-2.2	0.2
Hypothyroidism (self reported)	0.5	1.1	1.5	1.0	1.2	1.2	-0.5
Respiratory disease	1.2	2.6	3.9	1.1	1.7	1.5	-2.0
Type 2 Diabetes (T2D) (2018)	3.9	7.4	9.8	-2.5	-3.1	-3.1	2.0
Lung FEV1/FVC ratio	0.2	0.8	2.1	0.5	-0.7	-0.5	1.4
Lung FVC	1.5	7.4	10.1	-3.2	-2.6	-2.1	2.9
Neuroticism	0.6	1.4	2.1	1.3	1.3	1.4	-0.6
Chronotype (morning person)	1.6	3.7	10.2	-1.3	-1.5	-0.9	3.2
Hair Pigment	0.9	25.4	30.2	5.0	5.5	5.0	-4.6
Tanning	0.2	2.7	5.2	-1.2	-1.6	-1.2	2.3
Hand grip strength (left)	1.5	4.0	4.5	2.1	2.0	1.9	-1.9
Number of treatments/medications taken	0.3	0.6	1.0	-0.6	-0.4	-1.0	-1.0
Average weekly spirits intake	4.5	5.5	6.5	2.4	2.5	2.4	-1.9
Sensitivity / hurt feelings	0.4	0.6	1.3	1.1	0.8	0.8	0.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.3	-1.5	-1.3	-1.1	1.4
Hearing difficulty/problems: Yes	3.5	5.4	8.2	2.9	2.2	1.8	-2.2
Relative age of first facial hair	0.4	0.7	1.6	-1.3	-0.8	-0.7	0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.0	0.1	0.5	0.3	-1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.2	-0.2	-0.6	-0.2	1.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.6	-0.1	-0.0	0.1
Systolic blood pressure, automated reading	0.1	0.4	1.2	-0.2	0.5	-0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	0.0	0.1	-0.3
Angina	3.0	3.9	4.9	-2.1	-2.2	-2.1	1.4
Medication for hormone replacement therapy	0.3	0.3	1.1	-0.4	-0.4	-0.1	1.1
Vitamin and mineral supplements	0.3	0.4	0.5	-0.5	-0.7	-0.7	0.6
Supplements: Zinc	0.1	0.1	0.3	-0.1	-0.2	-0.3	-0.5
Medication: Co-codamol	1.8	2.1	3.4	-1.7	-1.5	-1.8	-0.1
Medication: Metformin	3.3	4.6	6.0	-2.3	-2.4	-2.5	1.1
Diabetes (father)	0.6	0.8	1.8	-0.3	-0.9	-0.7	1.3
Diabetes (mother)	1.1	1.5	1.9	-1.4	-1.3	-1.1	1.0
Severe depression (siblings)	0.0	0.0	0.1	0.1	0.1	-0.1	-0.2
Pack years adult smoking proportion	2.1	3.3	4.6	-2.1	-2.0	-1.7	1.4
Impedance of leg (right)	2.3	11.1	17.7	-3.8	-2.9	-1.9	4.2
Leg fat-free mass (left)	5.4	28.5	45.2	4.8	5.2	4.3	-6.7
Trunk fat percentage	0.0	0.1	0.3	-0.4	0.2	0.1	-0.6
Hand grip strength (right)	3.2	8.7	10.4	2.6	3.1	2.8	-3.2
Townsend deprivation index at recruitment	4.9	6.9	7.8	-2.8	-2.8	-2.7	2.2
Current tobacco smoking	0.3	0.5	1.4	0.0	0.5	1.2	0.6
Average weekly fortified wine intake	2.9	3.5	5.4	2.3	1.9	1.7	-1.4
Maternal smoking around birth	1.8	2.6	4.5	1.3	1.9	2.1	-0.8
Fed-up feelings	0.1	0.1	0.3	-0.4	0.1	0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	3.4	-1.8	-1.5	-1.2	1.3
Relative age voice broke	0.0	0.1	0.2	-0.3	0.1	0.0	-0.4
Taking other prescription medications	0.3	0.4	1.0	0.5	0.6	0.4	-1.0
Age when periods started (menarche)	0.1	0.3	1.1	1.0	0.4	0.3	0.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.3	-0.4	-0.9	-0.7	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.7	0.1	1.3	1.4	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.4	0.5	0.4	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.5	-0.6	-0.7	0.3
Serious illness, injury or assault to yourself	1.7	2.0	2.9	-1.7	-1.5	-1.7	0.0
High blood pressure	0.2	0.4	1.4	-0.2	-0.2	-0.5	-1.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.5	-0.3	-0.2	0.5
Multivitamins +/- minerals	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.6
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Supplements: Glucosamine	0.3	0.4	0.9	-0.1	0.4	0.9	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.1	-0.4	-0.6	-0.3
Medication: Atenolol	0.5	0.6	1.0	-0.3	-0.9	-0.7	1.0
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.5	0.1	0.3	0.3
Sitting height	11.2	79.2	110.2	7.7	9.1	8.0	-10.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	0.8	0.6	0.1	-0.8
High blood pressure (mother)	0.4	0.6	1.4	-0.5	-0.9	-1.2	-0.1
Body mass index (BMI)	0.0	0.1	0.4	-0.2	-0.0	-0.3	-0.7
Impedance of leg (left)	2.1	10.0	17.6	-3.2	-2.9	-2.0	4.2
Leg predicted mass (left)	5.2	27.7	44.0	4.7	5.2	4.3	-6.6
Trunk fat mass	0.8	3.5	6.7	1.2	1.9	1.6	-2.6
Waist circumference	0.7	2.6	5.7	1.2	1.5	1.0	-2.4
Number of incorrect matches in round	0.1	0.2	0.4	0.2	-0.6	-0.4	0.6
Past tobacco smoking	1.3	2.5	4.5	-0.9	-1.6	-1.4	2.1
Alcohol usually taken with meals	5.2	8.4	10.2	3.2	2.9	2.3	-3.1
Nervous feelings	0.0	0.1	0.2	-0.0	0.2	-0.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	7.5	-2.7	-2.4	-2.1	2.2
Hearing difficulty/problems with background noise	1.1	1.7	2.1	1.5	1.3	1.1	-1.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.7	0.0	-0.3	-0.5
Had menopause	0.0	0.0	0.0	-0.0	0.1	0.2	0.0
Had other major operations	1.9	2.3	3.5	1.9	1.5	1.3	-1.3
Forced vital capacity (FVC)	0.3	1.1	2.1	-0.1	1.1	1.0	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-0.2	0.7	0.7	-1.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.2
Qualifications: None of the above	3.4	7.2	7.8	-2.5	-2.8	-2.7	2.7
Financial difficulties in last 2 years	0.3	0.4	1.4	-1.2	-0.3	0.1	0.6
Mouth/teeth dental problems	0.1	0.1	0.3	0.3	0.2	0.2	-0.5
Heart attack	0.5	0.7	1.4	-1.2	-0.8	-0.7	0.5
Allergy	0.1	0.2	0.4	0.6	0.3	0.3	-0.4
Pain all over the body in last month	1.3	1.4	3.1	-1.8	-1.0	-0.9	0.9
Diabetes (self-reported)	4.0	6.2	8.7	-2.0	-2.9	-2.9	2.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.1	0.3	-0.1	-0.5
Medication: Ramipril	0.9	1.2	1.8	-1.3	-1.1	-1.3	0.1
Medication: Simvastatin	0.0	0.1	0.2	0.4	-0.1	-0.0	-0.2
Fluid intelligence score	0.0	0.1	0.2	0.5	0.0	-0.2	-0.3
Illnesses of siblings	0.2	0.2	0.5	0.0	-0.5	-0.4	0.7
Neuroticism score	0.1	0.1	0.3	0.5	0.3	0.3	-0.2
Weight	3.1	15.2	23.5	3.3	3.9	3.3	-4.9
Impedance of arm (right)	1.3	6.0	8.6	-2.9	-2.4	-1.8	2.6
Arm fat percentage (right)	0.8	3.0	4.9	-2.2	-1.8	-1.8	0.9
Trunk fat-free mass	7.2	41.3	54.6	5.9	6.5	5.8	-7.4
Hip circumference	2.4	10.2	15.4	2.5	3.3	2.9	-3.9
Time employed in main current job	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.1
Alcohol intake versus 10 years previously	1.9	2.8	3.2	-1.8	-1.7	-1.6	1.6
Father’s age at death	9.1	12.2	16.3	3.7	3.8	4.0	-2.1
Worrier / anxious feelings	0.1	0.2	0.8	0.9	0.2	0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	9.5	-3.1	-2.5	-2.2	2.3
Falls in the last year	1.3	1.7	2.7	-1.1	-1.5	-1.6	0.8
Hair/balding pattern: Pattern 3	1.6	2.4	5.4	2.3	1.2	0.8	-1.4
Number of live births	0.4	0.5	1.3	0.2	0.8	1.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.0	0.4	0.4	-0.3
Pulse rate	0.8	1.4	2.0	0.5	1.3	1.2	-1.4
Happiness	1.3	1.6	1.9	-1.3	-1.4	-1.3	1.0
Noisy workplace	3.1	3.8	5.4	-2.1	-2.0	-2.3	1.1
Qualifications: A levels/AS levels or equivalent	7.6	16.9	18.7	4.1	4.3	3.6	-4.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	-0.4	-0.6	-0.8	0.4
Mouth/teeth dental problems: Dentures	1.8	3.0	6.9	-1.7	-1.4	-0.7	2.6
Asthma	0.2	0.3	0.7	-0.8	-0.4	-0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.7	-0.0	-0.8	-0.7	1.3
Medication: Cholesterol lowering	1.2	1.9	2.5	-0.9	-1.6	-1.6	1.3
Depression (self-reported)	0.5	0.6	0.7	-0.8	-0.9	-0.7	0.8
Medication: Lansoprazole	0.2	0.3	0.5	0.3	0.7	0.5	-0.5
Prospective memory result	1.2	1.5	2.6	-0.3	1.3	1.3	-1.6
Lung cancer (father)	0.4	0.5	0.8	0.5	0.8	0.6	-0.9
Illnesses of mother	0.3	0.3	0.8	0.4	-0.7	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.8	0.8	0.7	0.7	-0.9
Pulse wave Arterial Stiffness index	1.9	2.2	3.8	-0.0	1.7	2.0	-1.4
Impedance of arm (left)	0.7	3.4	4.7	-2.2	-1.7	-1.2	2.2
Arm fat mass (right)	0.2	0.7	2.5	-0.1	0.5	0.3	-1.6
Trunk predicted mass	7.3	41.6	54.5	6.0	6.6	5.8	-7.4
Standing height	7.0	69.6	81.7	7.7	8.6	7.9	-9.0
Length of working week for main job	2.6	2.8	3.7	-1.5	-1.7	-1.5	1.9
Exposure to tobacco smoke at home	0.7	0.8	1.8	-1.3	-0.9	-0.8	0.2
Breastfed as a baby	0.7	0.8	1.3	0.6	1.2	1.1	-0.8
Tense / ‘highly strung’	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	5.9	-2.4	-2.0	-1.7	2.0
Hair/balding pattern: Pattern 4	0.9	2.3	3.0	-1.7	-1.6	-1.3	1.4
Birth weight of first child	0.6	1.1	1.9	1.4	1.0	0.6	-1.0
Peak expiratory flow (PEF)	0.6	1.4	2.9	1.7	1.2	1.2	-0.1
Pulse wave reflection index	1.2	1.5	3.1	0.0	1.5	1.8	-0.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	0.7	1.0	0.8	-1.5
Loud music exposure frequency	0.9	1.0	1.8	1.4	1.0	0.9	-0.5
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	3.7	1.9	1.7	1.3	-1.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.0	0.8	1.0	0.6	-1.4
Blood clot in the leg (DVT)	1.4	1.9	3.1	1.5	1.3	1.8	0.8
Medication: Paracetamol	0.4	0.6	1.0	-0.8	-0.8	-1.0	0.2
Headache pain in last month	0.9	1.6	3.4	0.5	1.6	1.9	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	0.2	0.8	0.9	-0.4
Glaucoma (self-reported)	0.4	0.5	0.9	0.4	-0.7	-0.6	1.0
Gout (self-reported)	3.3	4.6	7.3	1.9	2.2	1.6	-2.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	1.1	0.9	0.8	-0.5
Medication: Amlodipine	0.6	0.9	1.8	-0.8	-0.9	-1.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.8	-1.1	0.1	-0.2	-1.4
Birth weight	0.2	0.3	0.8	0.9	0.4	0.3	-0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.8	0.2	1.3	1.4	-1.3
High blood pressure (siblings)	1.0	1.4	2.3	0.6	1.5	1.5	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.1	3.3	0.9	1.5	1.4	-1.8
Body fat percentage	0.1	0.5	1.4	-1.2	-0.5	-0.5	0.0
Leg fat percentage (right)	0.5	1.7	4.2	-2.1	-1.0	-0.9	0.9
Arm fat-free mass (right)	7.2	36.8	49.8	5.7	6.1	5.3	-7.1
Exposure to tobacco smoke outside home	0.5	0.6	1.5	0.6	0.8	1.2	-0.3
Comparative body size at age 10	0.5	1.4	3.0	-1.7	-1.0	-0.6	1.1
Number of full brothers	0.4	0.5	1.1	-0.6	-0.8	-1.1	0.3
Worry too long after embarrassment	0.6	1.0	2.0	1.4	1.0	1.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.1	-0.9	-0.8	0.2
Wheeze or whistling in the chest in last year	1.8	3.3	6.1	1.4	1.8	1.3	-2.5
Number of children fathered	1.6	1.9	3.0	0.2	1.7	1.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.2	0.2	-1.1	-0.8	1.8
Age at first live birth	2.1	3.8	8.2	1.8	1.6	1.0	-2.9
Pulse wave peak to peak time	0.9	1.1	2.3	0.4	-1.2	-1.5	0.7
Health satisfaction	0.4	0.5	1.4	-0.4	-0.6	-0.4	1.2
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.1	0.5	0.6	-0.5
Qualifications: College or University degree	4.6	14.5	24.5	3.3	3.6	3.0	-5.0
Eye problems/disorders: None of the above	0.4	0.5	0.8	-0.4	-0.9	-0.8	0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	0.5	0.7	0.3	-1.4
Emphysema/chronic bronchitis	0.6	0.7	1.7	-1.3	-0.3	-0.6	-0.7
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.1	0.5	0.7	0.0
Neck or shoulder pain in last month	5.0	7.2	8.2	-2.9	-2.8	-2.5	2.5
Medication: Blood pressure	0.2	0.4	1.1	-0.1	-0.8	-1.0	0.1
Angina (self-reported)	3.5	4.7	5.8	-2.2	-2.4	-2.2	1.7
Migraine (self-reported)	0.3	0.4	0.8	0.9	0.4	0.5	0.7
Medication: Ibuprofen	1.9	2.3	3.7	-0.7	-1.6	-1.5	1.9
Medication: Allopurinol	2.5	3.3	7.0	0.7	1.9	1.4	-2.6
Medication: Omeprazole	2.4	2.9	3.8	-1.6	-2.0	-1.9	1.4
Medication: Seretide 50 evohaler	0.9	1.1	1.4	1.0	1.2	1.2	-0.5
Mean time to correctly identify matches	0.8	1.5	3.4	-1.3	-0.4	-0.8	-1.8
Heart disease (mother)	0.0	0.1	0.1	-0.3	0.2	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	1.1	0.6	0.8	0.5
Whole body fat mass	0.6	2.7	5.6	1.0	1.6	1.3	-2.4
Leg fat mass (right)	0.3	1.2	2.6	0.3	1.1	0.9	-1.6
Arm predicted mass (right)	6.8	34.5	47.1	5.4	5.9	5.2	-6.9
Pulse rate, automated reading	3.3	10.6	18.3	2.4	3.3	2.7	-4.3
Alcohol intake frequency.	3.5	8.2	9.5	-3.0	-2.8	-2.5	3.1
Comparative height size at age 10	7.3	40.0	45.7	5.6	6.8	6.4	-6.4
Number of full sisters	2.5	3.1	7.3	-2.7	-1.3	-0.8	1.6
Suffer from ‘nerves’	0.2	0.3	0.8	0.7	0.2	-0.0	-0.9
Overall health rating	0.4	1.0	1.6	-1.3	-0.9	-1.1	-0.0
Chest pain or discomfort	0.9	1.2	2.0	1.4	1.0	1.1	-0.8
Had major operations	0.3	0.4	0.6	-0.8	0.4	0.5	-0.7
Age at last live birth	1.2	1.7	5.0	0.4	1.1	0.8	-2.2
Family relationship satisfaction	0.1	0.1	0.2	-0.2	0.4	0.4	-0.2
Leg pain on walking	0.1	0.1	0.3	-0.6	-0.1	0.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.4	-0.4	-0.3	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.2	0.3	0.3	-0.8
Medication: Aspirin	0.4	0.6	1.3	0.4	-0.2	-0.8	-1.1
Supplements: Vitamin C	1.6	1.9	2.7	1.6	1.3	1.2	-1.3
Knee pain experienced in last month	0.3	0.5	0.9	0.0	0.9	0.9	-0.4
Hypertension (Self-reported)	0.1	0.4	0.8	-0.1	-0.4	-0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-1.1	-0.3	-0.5	-0.2
Illnesses of father: Heart disease	1.8	2.6	5.8	-2.4	-1.5	-1.4	0.7
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3
Smoking status: Previous	0.7	1.0	3.2	0.4	0.8	0.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	4.3	9.0	11.6	3.0	3.0	2.5	-3.4
Whole body fat-free mass	6.9	39.5	55.8	5.8	6.3	5.4	-7.5
Leg fat-free mass (right)	5.7	30.5	46.9	5.3	5.3	4.3	-6.8
Arm fat percentage (left)	0.5	1.9	3.3	-1.8	-1.4	-1.4	0.6
Average weekly red wine intake	0.6	0.9	1.9	-0.4	-0.9	-0.8	1.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.1	-0.4	-0.4	0.4
Mood swings	1.3	2.3	2.9	-1.5	-1.5	-1.3	1.7
Loneliness, isolation	0.1	0.1	0.2	-0.3	-0.1	0.3	0.4
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.9	-0.7	-0.7	0.1
Ever had bowel cancer screening	2.2	2.6	4.8	2.2	1.6	1.2	-1.3
Diabetes diagnosed by doctor	5.8	9.5	13.5	-2.8	-3.6	-3.7	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.5	0.1	0.6	0.7	-0.4
Friendships satisfaction	0.1	0.1	0.3	-0.3	0.0	-0.2	-0.6
Qualifications: nursing, teaching	2.1	3.3	5.0	2.1	1.5	1.2	-2.2
Commuting to job workplace: Walk	0.4	0.4	0.9	0.9	0.6	0.4	-0.4
Eye problems/disorders: Cataract	0.6	0.7	1.2	-1.1	-0.8	-0.9	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.4	0.1	-0.2	-0.4
Medication for cholesterol	0.2	0.3	0.9	0.1	0.5	0.3	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.7	0.9	1.3	1.2	-1.1
Back pain experienced in last month	0.4	0.6	1.1	0.7	0.7	1.0	0.4
Mineral and other dietary supplements	0.1	0.2	0.4	0.6	0.4	0.4	0.0
Breast cancer (self-reported)	0.2	0.2	0.6	-0.8	-0.1	0.2	-0.4
Asthma (self-reported)	0.2	0.3	0.7	-0.8	-0.2	-0.5	-0.5
Osteoporosis (self-reported)	0.1	0.2	0.5	-0.3	-0.1	0.1	0.7
Osteoarthritis (self-reported)	0.4	0.6	1.3	-0.2	-0.7	-0.6	1.2
Medication: Aspirin	0.6	0.8	1.7	0.2	-0.6	-1.3	-1.0
Medication: Gliclazide	0.3	0.3	0.4	-0.6	-0.7	-0.6	0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.1	-0.4	-0.5	0.1
Smoking status: Current	0.8	1.3	3.2	0.6	1.3	1.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	6.5	-1.5	-2.2	-2.1	2.6
Whole body water mass	6.7	38.4	55.2	5.6	6.2	5.3	-7.4
Leg predicted mass (right)	5.7	30.6	47.1	5.3	5.3	4.3	-6.9
Arm fat mass (left)	0.3	1.3	3.5	0.4	1.1	0.8	-1.9
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	0.5	0.0	-0.1	0.3
Average weekly champagne plus white wine intake	12.9	17.8	19.9	4.1	4.5	4.2	-4.2
Miserableness	0.2	0.4	1.1	0.4	0.6	0.2	-1.0
Guilty feelings	0.3	0.5	1.0	-0.3	-0.7	-0.6	1.0
Wears glasses or contact lenses	1.7	2.0	3.8	1.0	1.6	1.9	-0.8
Ever taken oral contraceptive pill	0.9	1.0	1.8	-0.7	-1.3	-1.3	0.5
Hearing aid user	0.9	1.1	1.5	0.9	1.2	0.7	-1.2
Mother’s age at death	3.7	4.6	6.0	1.9	2.4	2.4	-1.8
Financial situation satisfaction	3.3	4.1	6.2	-1.5	-2.1	-1.9	2.5
Tinnitus: Yes, now most or all of the time	1.6	1.8	2.6	1.6	1.4	1.5	-0.6
Commuting to job workplace: Public transport	3.5	4.2	5.3	2.3	2.1	2.0	-1.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.7	-0.0	0.0	0.8
Medication: Blood pressure	0.2	0.3	0.4	-0.4	-0.5	-0.6	-0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.9	-1.0	-1.2	-0.8	1.4
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.4	0.1	-0.6	-0.6	0.5
Medication: Bendroflumethiazide	0.6	1.0	1.7	0.0	-1.2	-1.3	0.8
Medication: Paracetamol	0.5	0.8	1.4	-1.0	-0.9	-1.2	0.2
Medication: Lisinopril	4.9	6.4	9.3	-2.7	-2.8	-3.0	1.0
Medication: Atorvastatin	3.8	4.7	10.6	-1.6	-2.4	-3.3	-0.2
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.4	-0.4	-0.7	-0.9
Alcohol drinker status: Never	2.6	3.1	4.1	-1.1	-2.0	-1.9	1.8
Ever smoked	0.9	1.6	2.0	0.9	1.4	1.4	-1.4
Basal metabolic rate	5.9	32.7	48.3	5.2	5.7	4.8	-7.0
Leg fat percentage (left)	0.4	1.4	2.8	-1.7	-1.0	-0.9	0.9
Arm fat-free mass (left)	6.6	33.5	46.2	5.1	5.9	5.2	-6.8
Number of operations (self-reported)	0.3	0.5	0.7	0.3	0.9	0.7	-0.8
Average weekly beer plus cider intake	2.7	3.9	5.3	-2.0	-2.1	-2.3	1.3
Irritability	0.0	0.1	0.2	-0.4	-0.0	0.2	-0.0
Risk taking	0.2	0.3	0.5	-0.7	-0.5	-0.3	0.6
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.0	1.2	1.7	1.6	-1.2
Fractured/broken bones in last 5 years	0.9	1.2	2.7	-0.2	-1.4	-1.7	0.2
Age started oral contraceptive pill	2.2	2.8	5.6	1.6	1.4	1.1	-2.4
Diastolic blood pressure, automated reading	0.1	0.2	0.6	-0.0	0.3	-0.2	-0.8
Ever depressed for a whole week	0.2	0.2	0.6	0.4	0.2	-0.0	-0.8
Unable to work because of sickness or disability	1.9	2.5	3.9	-2.0	-1.5	-1.3	1.4
Commuting to job workplace: Cycle	2.0	2.4	5.1	0.4	1.6	1.4	-2.3
Myopia	0.5	0.7	0.8	-0.7	-0.9	-0.8	0.9
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	0.7	0.8	1.1	0.5
Cholesterol lowering medication	0.3	0.5	1.0	-0.3	-0.9	-1.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.5	-0.7	-1.1	-1.2	0.7
Pain experienced in last month	0.2	0.4	0.8	-0.3	-0.7	-0.9	-0.2
Supplements: Calcium	0.4	0.4	1.2	0.0	0.5	0.4	-1.1
Basal cell carcinoma (self-reported)	0.5	0.7	1.8	-1.3	-0.4	-0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.9	-0.6	-0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.5	1.4	1.0	1.6	1.0
Heart disease (siblings)	0.6	0.7	1.0	-0.6	-1.0	-1.0	0.7
Alcohol drinker status: Previous	8.2	9.4	11.0	-3.1	-3.3	-3.1	2.7
Pack years of smoking	1.6	2.3	3.3	-1.8	-1.7	-1.5	1.0
Impedance of whole body	1.4	7.4	11.9	-2.9	-2.5	-1.8	3.5
Leg fat mass (left)	0.3	1.0	2.2	0.4	1.0	0.8	-1.5
Arm predicted mass (left)	5.5	27.8	39.6	4.7	5.3	4.6	-6.3