Best TWAS P=1.33e-60 · Best GWAS P=5.21e-63 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEK10 | 0.04 | 0.03 | blup | 450 | 0.03 | 9.5e-05 | -3.2 | 8.8 | 9.4e-19 | 0.61 | 0.50 | 0.30 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC4A7 | 0.09 | 0.00 | enet | 27 | 0.04 | 2.9e-05 | -1.0 | 6.6 | 3.2e-11 | 0.33 | 0.20 | 0.10 | TRUE |
| 3 | GTEx | Artery Aorta | SLC4A7 | 0.10 | 0.08 | enet | 15 | 0.08 | 5.4e-05 | 10.8 | 10.3 | 5.1e-25 | 0.65 | 0.26 | 0.52 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | 10.8 | 9.2 | 2.4e-20 | 0.58 | 0.54 | 0.08 | TRUE |
| 5 | GTEx | Muscle Skeletal | SLC4A7 | 0.07 | 0.05 | lasso | 3 | 0.04 | 5.9e-05 | -13.4 | -13.4 | 3.9e-41 | -0.54 | 0.52 | 0.04 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | 15.0 | -16.4 | 1.3e-60 | -0.90 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC4A7 | 0.02 | 0.02 | blup | 69 | 0.01 | 3.7e-04 | 15.1 | -16.0 | 2.1e-57 | -0.88 | 0.04 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK10 | 0.04 | 0.04 | lasso | 2 | 0.03 | 3.0e-04 | 15.8 | -16.0 | 1.9e-57 | -0.90 | 0.01 | 0.98 | TRUE |