Hub : Genes

TLR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0290	1.6e-04	0.066	0.031	0.054	0.043	0.067	1.7e-08	1.1e-04	3.5e-07	4.6e-06	1.3e-08
2	GTEx	Esophagus Mucosa	0.2000	0.0540	5.8e-06	0.019	NA	0.037	NA	0.041	1.9e-02	NA	1.7e-03	NA	9.8e-04
3	GTEx	Esophagus Muscularis	0.2090	0.0600	1.3e-04	0.024	NA	0.057	NA	0.032	1.3e-02	NA	2.3e-04	NA	4.5e-03
4	NTR	Blood	0.0341	0.0132	6.3e-04	0.001	0.006	0.001	0.006	0.001	2.0e-01	4.7e-03	9.3e-02	3.0e-03	1.7e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0789	0.0265	1.3e-04	0.017	0.035	0.013	0.032	0.015	2.2e-03	2.3e-05	8.0e-03	5.3e-05	4.3e-03
6	YFS	Blood	0.0805	0.0239	4.7e-11	0.053	0.031	0.047	0.066	0.049	5.2e-17	1.6e-10	4.4e-15	1.2e-20	8.7e-16
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0377	0.0208	8.4e-05	0.033	0.034	0.034	NA	0.035	1.0e-04	8.5e-05	8.7e-05	NA	8.1e-05
8	TCGA	Liver Hepatocellular Carcinoma	0.1440	0.0680	1.9e-05	0.073	0.097	0.101	NA	0.095	2.4e-04	2.5e-05	1.7e-05	NA	3.2e-05
9	TCGA	Lung Squamous Cell Carcinoma	0.0317	0.0186	6.3e-04	0.026	0.028	0.032	NA	0.026	5.3e-04	3.2e-04	1.5e-04	NA	5.9e-04
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.0760	0.0430	4.5e-03	0.023	0.036	0.039	NA	0.028	1.1e-02	1.8e-03	1.2e-03	NA	5.2e-03
11	TCGA	Uterine Corpus Endometrial Carcinoma	0.1250	0.0680	3.1e-03	0.128	0.068	0.083	NA	0.080	2.0e-04	5.9e-03	2.6e-03	NA	3.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.3	1.6	-0.6	0.3	0.1	-0.7	-1.3	-0.3	0.7	0.4	-0.4	0.2	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	3.9	-0.1	-0.2	-0.1	-2.0	-0.6	-0.6	0.2	0.1	-0.4	-0.5	0.4
Depressed Affect (Nagel 2018)	0.1	0.3	1.3	-0.4	-0.0	-0.1	-1.1	0.4	0.3	0.3	-0.1	-0.8	0.4	-0.7
Depression (Nagel 2018)	0.3	0.4	1.6	-0.5	0.4	-0.0	0.8	-0.8	-0.5	0.4	-0.1	-0.8	-0.3	-1.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.8	-0.7	1.1	0.7	0.2	-2.2	0.6	0.7	0.5	-0.3	0.6	1.2
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.8	0.2	0.1	-0.5	0.2	0.9	0.7	0.0	-0.7	0.3	-0.8
Schizophrenia (2018)	0.3	0.7	3.8	0.4	-0.5	-0.2	-2.0	0.3	-0.1	-0.3	-0.6	0.1	-1.3	0.9
Schizophrenia vs Biploar Disorder	0.8	1.0	4.5	-0.3	0.8	-0.5	-0.3	0.2	2.0	0.4	0.6	-0.1	-0.9	2.1
Worry (Nagel 2018)	0.2	0.4	2.8	-0.6	-0.3	0.8	-0.4	0.2	1.7	0.6	-0.1	-0.2	-0.1	-0.1
Alzheimer’s Disease (in mother)	0.1	0.2	0.8	-0.1	-0.3	0.2	0.9	0.5	0.0	0.2	0.1	0.0	-0.7	0.3
Alzheimer’s Disease (in father)	1.9	2.0	6.0	1.4	-1.4	1.0	-0.9	1.1	-1.6	-2.0	-1.2	-0.6	1.2	-2.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.6	0.8	-1.5	0.0	-0.1	1.6	-0.8	-0.9	-0.6	-0.3	-0.2	-0.6
Crohns Disease (2017)	1.1	2.5	6.9	-2.6	1.9	0.1	1.2	-2.0	0.8	2.3	1.8	0.8	-1.0	0.0
Irritable Bowel Disease (IBD)	0.5	1.3	3.5	-1.7	0.9	-1.0	0.2	-1.9	-0.4	1.1	0.8	0.9	-0.7	-1.5
Ulcerative Colitis (UC)	0.5	0.9	2.8	-0.6	-0.1	-1.5	-1.1	-1.2	-0.7	0.1	-0.1	1.0	-0.5	-1.7
Major Depression (MDD)	0.7	0.9	2.8	0.5	-0.3	-1.7	-0.3	1.4	0.7	-0.7	-1.3	0.1	-1.1	-0.7
Reaction Time	0.7	1.3	3.6	-0.8	0.9	-1.9	0.7	-0.0	1.4	1.5	0.9	-0.2	-1.2	1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.6	3.5	0.4	-0.4	-0.2	-0.6	-1.1	-0.9	-0.6	-0.4	0.0	1.9	0.1
Breast Cancer	10.4	25.1	43.8	-6.3	5.0	4.5	2.5	-3.4	5.3	6.6	5.8	3.8	3.2	6.6
Ovarian Cancer	2.1	2.7	7.1	-1.5	2.6	2.7	1.6	-0.9	2.6	1.6	0.7	1.1	-0.0	-0.0
Prostate Cancer	0.8	1.2	4.2	-0.3	0.9	1.7	-1.1	-1.4	0.3	0.3	0.3	0.9	2.1	0.7
Age at First Birth	0.3	0.4	1.9	-0.2	0.4	-0.0	1.4	-1.3	0.5	0.0	-0.2	0.9	0.1	0.1
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.0	0.0	0.6	-0.4	-0.3	0.1	-0.2	-0.8	0.2	-0.3	-0.8
Body Mass Index (BMI) (2010)	0.8	1.1	2.9	1.2	-0.6	-1.2	0.5	1.7	-1.2	-1.1	-0.6	-1.2	-0.8	-0.5
Coronary Artery Disease (CAD)	1.5	1.8	6.8	-0.7	1.7	-0.3	1.6	-0.7	0.3	0.8	1.7	1.4	2.6	1.1
Crohns Disease (2012)	1.5	2.5	7.0	-2.6	1.9	0.3	0.6	-2.2	0.8	2.4	2.0	0.4	1.0	0.6
Mean Putamen Volume	2.3	2.6	4.5	2.0	-1.5	-0.9	-1.9	1.9	-1.8	-2.1	-1.9	-0.9	-0.3	-1.2
Fasting Glucose	0.4	0.4	2.4	0.1	0.4	0.5	0.7	0.1	-0.4	-0.2	0.4	0.7	1.6	-0.7
HbA1C	0.7	0.8	1.5	0.7	-0.9	-0.9	-0.3	1.2	-1.1	-0.9	-1.0	0.5	-1.0	-1.1
HDL Cholesterol	1.8	3.0	5.2	-1.9	1.5	1.4	1.9	-1.7	1.9	2.3	1.7	1.5	0.5	2.2
LDL Cholesterol	0.3	0.4	1.1	0.4	0.3	-0.6	0.9	-0.2	-0.3	-0.5	-0.5	-0.9	-0.6	-1.1
Lupus	0.4	0.6	2.1	0.5	-1.1	-0.4	-0.3	0.2	-1.4	-0.7	-0.1	-0.3	1.4	-0.1
Neuroticism (2016)	1.0	1.4	5.6	-1.3	1.0	1.1	-0.4	-0.1	2.4	1.3	0.4	-0.9	-1.4	1.1
Primary Biliary Cirrhosis	0.5	0.7	3.1	0.6	0.2	-1.8	0.7	-1.0	-0.2	-0.6	-0.8	-0.4	-0.4	-1.4
Rheumatoid Arthritis	0.4	0.6	2.5	0.5	-0.4	-1.6	0.8	-0.1	-0.1	-0.3	-0.0	-1.1	-1.0	-0.7
Schizophrenia (2014)	0.3	0.7	3.0	-0.5	0.1	0.9	-1.7	-0.5	-0.0	0.6	0.5	0.5	-0.4	1.4
Triglycerides	0.5	0.9	2.7	0.4	-0.3	0.1	-0.4	0.2	-0.8	-0.5	-1.3	-1.6	-1.0	-1.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	4.5	0.5	-0.4	-0.3	0.5	2.1	-0.4	-0.4	-1.2	-0.8	-1.4	-0.4
Ulcerative Colitis	0.7	1.1	4.2	-0.0	-0.6	-0.4	-1.7	-0.7	-1.6	-0.5	-0.7	-0.4	-0.3	-2.0
Blood Eosinophil Count	1.8	13.5	50.8	2.4	-2.2	-3.2	7.1	3.5	-2.1	-3.2	-2.0	-2.0	-1.2	-6.4
Blood Platelet Count	0.6	7.3	24.1	-2.9	2.2	0.1	1.8	-2.5	3.0	3.4	3.0	1.8	0.1	4.9
Blood Red Count	1.2	11.3	43.0	3.4	-2.8	-1.7	-0.7	3.1	-3.5	-4.2	-3.6	-2.2	-0.9	-6.6
Blood White Count	1.1	8.3	21.3	-3.3	2.5	0.5	-1.2	-3.2	2.1	3.7	3.5	2.1	2.5	4.6
Heel T-Score	0.3	2.5	13.2	1.4	-1.1	3.6	-0.4	1.9	-0.4	-1.4	-1.4	-1.6	-1.0	-0.5
BMI	2.3	13.5	26.6	4.2	-3.2	-0.7	-1.7	4.3	-3.9	-4.6	-3.8	-4.1	-2.1	-5.2
Height	0.4	8.6	24.0	-1.9	3.8	3.8	-0.2	-4.5	2.2	1.1	0.8	1.0	4.9	-3.2
Waist Hip Ratio (WHR)	0.5	2.1	6.7	-1.5	0.9	2.0	-0.1	-0.6	0.3	1.9	2.6	0.9	1.0	1.8
Systolic Blood Pressure	1.3	6.4	18.1	-2.9	2.7	4.2	2.8	-0.7	2.8	2.6	2.3	1.9	1.5	1.5
Smoking Status	0.5	1.2	4.7	-0.8	1.0	0.9	0.4	1.0	1.0	1.1	0.8	0.8	-1.0	2.2
Allergy or Eczema	102.4	269.6	432.6	-20.1	19.5	12.9	12.3	-17.5	17.1	20.8	18.2	13.4	7.4	16.3
Cardiovascular Disease	0.3	0.9	3.0	0.6	0.5	0.7	1.3	1.7	0.1	-0.8	-0.8	-0.7	0.4	-1.4
Hypothyroidism (self reported)	5.1	11.6	19.8	4.2	-3.7	-1.3	-1.4	3.0	-3.2	-4.4	-4.0	-4.5	-1.7	-3.9
Respiratory disease	19.1	42.4	67.3	-8.1	7.5	6.7	4.6	-5.8	6.2	8.2	7.6	5.6	2.8	6.6
Type 2 Diabetes (T2D) (2018)	1.1	2.0	8.6	1.7	-1.4	0.6	-0.6	2.9	-1.1	-1.6	-1.1	-0.8	0.5	-1.3
Lung FEV1/FVC ratio	1.2	6.0	14.5	2.2	-1.7	-3.8	-2.9	1.7	-1.8	-2.5	-2.4	-2.2	-1.7	-3.1
Lung FVC	0.3	1.6	5.1	1.8	-1.8	-0.2	-0.2	2.2	-1.0	-1.6	-0.8	-0.0	-1.3	-0.7
Neuroticism	0.2	0.4	1.5	-0.6	0.3	-0.0	-1.1	0.3	1.2	0.6	-0.1	-0.9	0.1	-0.2
Chronotype (morning person)	0.3	0.8	2.1	1.1	-0.9	-0.6	-0.7	-0.6	-0.3	-1.5	-1.3	0.2	-0.6	-1.0
Hair Pigment	0.1	4.0	17.4	2.1	-1.2	-1.3	0.2	1.2	-0.8	-2.5	-2.7	-1.8	-0.2	-4.2
Tanning	0.3	3.4	9.9	-2.4	1.4	0.5	0.1	-0.6	1.5	2.6	2.1	2.3	-0.2	3.1
Hand grip strength (left)	1.0	2.7	9.4	-1.7	1.7	3.1	0.4	-2.3	1.4	1.8	1.7	0.7	0.5	0.5
Number of treatments/medications taken	0.9	1.6	6.1	-1.0	1.5	2.5	1.0	0.1	1.8	1.0	0.8	0.6	0.3	1.3
Average weekly spirits intake	1.7	2.1	4.3	-2.1	2.0	1.4	0.1	-2.1	1.3	1.9	1.3	0.9	0.2	0.9
Sensitivity / hurt feelings	0.4	0.8	1.9	-1.2	0.7	-0.7	0.7	-0.8	1.3	1.4	0.7	0.0	-0.4	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	-1.0	1.0	0.6	0.6	-1.2	0.3	0.9	0.5	-0.1	0.2	0.3
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-0.2	0.4	-1.1	1.0	-0.8	-0.7	0.3	0.5	-0.3	-1.0	-0.6
Relative age of first facial hair	0.4	0.8	1.8	1.1	-0.9	-0.6	-0.5	-0.1	-1.0	-1.1	-1.3	-0.2	-0.5	-1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	0.8	-0.5	-0.4	-1.0	1.3	0.2	-0.7	-0.5	-1.3	-0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.7	-0.5	0.3	-1.2	1.2	0.0	-0.4	-1.1	-0.6	-0.7	-0.4
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	-0.0	-0.2	-1.2	0.2	0.3	-1.3	-0.2	-0.6	-0.4	-1.6	-1.1
Systolic blood pressure, automated reading	1.7	5.0	9.8	-2.5	2.7	3.1	2.7	-1.0	2.6	2.3	1.8	2.0	1.4	1.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.6	1.4	-0.9	-0.1	-0.8	1.1	-1.9	-1.4	-0.7	-1.0	0.1	-1.0
Angina	0.3	0.4	1.4	-0.4	0.7	0.1	1.1	1.2	0.3	0.7	0.4	0.1	-0.9	0.1
Medication for hormone replacement therapy	1.0	1.1	5.0	-0.4	-0.5	0.7	-0.3	0.3	0.4	0.8	1.4	1.6	0.9	2.2
Vitamin and mineral supplements	0.2	0.3	1.2	-0.3	-0.2	-0.1	1.1	0.2	-0.4	0.4	0.2	-0.7	-0.7	-0.4
Supplements: Zinc	0.1	0.1	0.2	0.2	0.0	-0.2	-0.5	-0.3	-0.2	-0.2	0.0	-0.5	0.4	-0.1
Medication: Co-codamol	1.2	1.4	3.4	-1.5	1.8	0.6	0.3	-1.8	0.3	1.5	1.4	-0.3	0.4	1.1
Medication: Metformin	0.2	0.3	1.3	0.0	0.1	0.8	-0.4	1.1	0.5	0.0	0.0	0.1	0.7	-0.2
Diabetes (father)	0.3	0.3	0.9	0.4	-0.5	1.0	0.3	-0.1	-0.5	-0.3	0.3	-0.8	0.9	-0.7
Diabetes (mother)	1.3	1.6	2.8	-1.7	0.7	1.6	-1.1	-1.6	0.2	1.4	1.5	0.7	1.3	1.5
Severe depression (siblings)	1.7	1.9	5.0	1.7	-1.7	-2.2	-0.0	1.8	-0.1	-1.3	-1.3	-0.3	-1.8	0.1
Pack years adult smoking proportion	0.3	0.5	1.6	0.8	-0.8	-1.3	-0.9	0.7	0.1	-0.6	-0.0	-0.3	-0.3	0.8
Impedance of leg (right)	0.8	3.8	6.2	-2.0	1.7	2.4	1.7	-2.3	2.5	2.3	1.3	1.5	-0.3	2.3
Leg fat-free mass (left)	0.9	4.7	15.7	2.4	-1.3	-0.7	-1.5	1.8	-2.4	-2.8	-2.0	-2.1	1.0	-4.0
Trunk fat percentage	1.0	4.1	10.7	2.4	-1.2	-0.3	0.0	2.1	-2.5	-2.6	-1.9	-2.6	-0.3	-3.3
Hand grip strength (right)	1.5	4.1	9.3	-2.2	2.0	3.0	1.1	-2.8	1.7	2.3	2.4	1.4	0.7	1.0
Townsend deprivation index at recruitment	0.8	1.1	2.5	-0.8	1.6	0.7	1.0	-1.6	1.5	1.0	0.8	-0.1	1.0	0.6
Current tobacco smoking	0.2	0.3	1.1	0.1	-0.3	0.8	-0.3	0.6	-1.0	0.1	0.4	-0.0	-0.5	1.0
Average weekly fortified wine intake	0.5	0.6	2.7	0.1	-0.3	-1.6	0.0	-0.5	-1.2	-0.5	-0.2	-0.2	1.4	-0.1
Maternal smoking around birth	0.2	0.3	1.2	0.5	-0.5	-0.8	-0.7	1.1	0.0	-0.4	-0.4	-0.7	-0.3	-0.2
Fed-up feelings	0.2	0.3	1.1	-0.9	0.5	0.4	-0.5	0.1	0.5	1.0	0.7	-0.1	-0.7	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.6	0.6	0.0	0.5	-0.9	-0.3	0.6	0.2	-0.7	-0.1	0.1
Relative age voice broke	1.1	1.7	3.5	-1.4	0.8	1.9	0.9	-1.0	1.1	1.5	1.5	1.6	0.3	1.5
Taking other prescription medications	1.9	2.9	9.8	-1.9	1.8	3.1	1.0	-0.3	1.8	1.9	1.7	1.2	0.1	1.6
Age when periods started (menarche)	0.3	0.8	4.0	-0.6	0.4	2.0	-0.6	-0.9	0.7	0.4	0.5	-0.6	-0.1	1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.8	-0.0	-0.8	-1.3	-0.7	0.8	-0.2	-0.0	-0.6	0.2	-0.9	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	7.7	-0.0	0.2	2.8	0.9	1.0	0.3	-0.2	0.1	-0.3	0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	-0.0	-0.3	-0.4	0.6	0.6	1.0	0.0	-0.6	-0.4	-1.3	0.1
Qualifications: CSEs or equivalent	3.0	4.0	8.2	2.8	-2.3	-1.4	-0.3	1.9	-1.2	-2.9	-2.8	-1.3	-0.8	-2.4
Serious illness, injury or assault to yourself	0.6	0.7	2.5	0.7	-0.4	-1.1	-0.7	0.6	-0.8	-0.9	-1.0	-0.3	-0.2	-1.6
High blood pressure	0.4	1.1	4.7	0.5	0.5	1.1	1.7	2.2	0.4	-0.7	-0.6	-0.3	-0.3	-1.3
Hayfever, allergic rhinitis or eczema	83.4	181.1	302.8	-16.6	15.8	9.8	10.1	-14.3	14.0	17.4	15.2	11.3	5.1	13.4
Multivitamins +/- minerals	1.0	1.2	2.8	1.6	-0.8	-0.4	-1.7	-0.0	-0.9	-1.5	-1.4	-1.2	0.1	-0.9
Stomach or abdominal pain in last month	1.0	1.2	5.2	1.0	-1.3	0.1	-1.5	2.3	-1.2	-0.9	-0.5	-1.0	-0.2	-0.2
Supplements: Glucosamine	0.4	0.5	1.8	0.9	-0.7	-1.4	-0.6	-0.1	-0.0	-0.9	-0.4	-0.5	1.0	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.4	0.2	0.0	-0.6	-1.2	0.2	0.0	0.0	-0.3	0.5	-0.4	0.8
Medication: Atenolol	0.6	0.7	2.3	-1.0	1.5	0.6	0.9	0.7	1.2	0.7	0.2	0.7	0.5	-0.1
Medication: Levothyroxine sodium	1.5	2.6	5.1	2.0	-2.3	-0.1	-1.0	1.3	-1.3	-2.2	-2.0	-1.6	0.1	-2.1
Sitting height	0.5	3.9	15.3	2.5	-1.1	0.5	-1.4	0.7	-0.9	-2.8	-2.1	-1.5	1.5	-3.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	0.7	-0.6	-0.4	-0.4	0.1	0.1	-0.8	-0.7	-0.5	-0.3	-0.1
High blood pressure (mother)	0.5	0.7	2.3	-0.8	0.5	1.5	0.6	-0.6	-0.1	0.7	1.1	0.9	1.1	-0.2
Body mass index (BMI)	0.7	2.9	8.3	1.8	-0.8	0.2	-0.6	2.2	-2.3	-2.0	-1.3	-1.8	-0.5	-2.9
Impedance of leg (left)	0.7	3.6	7.1	-2.0	1.5	2.7	1.2	-2.2	2.4	2.2	1.4	1.5	0.1	2.1
Leg predicted mass (left)	0.8	4.4	14.9	2.3	-1.2	-0.6	-1.5	1.6	-2.3	-2.7	-1.9	-2.0	1.1	-3.9
Trunk fat mass	1.1	4.8	15.8	2.4	-1.1	0.0	-0.3	2.1	-2.6	-2.8	-2.0	-2.7	-0.0	-4.0
Waist circumference	1.2	4.3	13.1	2.2	-1.3	0.3	-1.3	2.2	-3.0	-2.5	-1.6	-2.0	0.1	-3.6
Number of incorrect matches in round	0.3	0.5	2.5	-0.1	0.2	-1.6	0.7	1.1	-0.2	0.2	0.2	0.2	-1.1	0.2
Past tobacco smoking	0.4	0.7	2.3	-0.7	0.3	0.4	-0.2	-1.4	-0.6	0.2	0.6	1.0	1.5	-1.0
Alcohol usually taken with meals	1.1	1.7	3.3	1.8	-1.3	-1.8	-1.3	0.6	-0.1	-1.7	-1.5	-1.4	0.7	-0.9
Nervous feelings	0.4	0.7	2.3	-1.1	0.2	1.5	-0.4	-0.4	0.9	1.2	0.6	0.1	0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.6	-0.8	0.1	-0.6	0.3	-0.4	-0.4	-0.7	-0.5	-0.3	0.5
Hearing difficulty/problems with background noise	0.7	1.1	3.4	-0.4	0.5	-1.5	1.0	-1.8	-0.9	0.5	0.6	-0.6	-1.6	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.8	-0.9	0.0	-0.1	1.0	0.1	-1.0	-0.6	-0.6	-0.1	-0.3
Had menopause	0.2	0.3	1.1	-0.5	1.1	0.1	-0.0	-0.6	0.8	0.5	0.5	0.5	0.3	0.3
Had other major operations	0.3	0.4	2.9	0.3	-0.4	-1.7	0.2	0.2	-0.9	-0.3	-0.0	-0.3	-0.4	-0.3
Forced vital capacity (FVC)	0.1	0.5	1.5	0.7	-0.4	1.2	-0.0	0.1	-0.6	-0.7	0.1	-0.7	0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	8.6	-0.2	0.4	2.9	0.7	0.4	-0.1	-0.1	0.0	0.2	0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.2	-0.8	1.3	0.1	1.8	-0.5	1.5	0.8	0.6	1.1	-0.8	0.9
Qualifications: None of the above	1.5	3.3	5.8	-2.4	2.2	2.4	2.2	-0.1	1.6	2.0	1.7	1.8	0.3	1.4
Financial difficulties in last 2 years	0.2	0.2	0.7	0.2	-0.8	0.4	-0.7	-0.2	-0.8	-0.1	0.5	-0.0	0.1	0.5
Mouth/teeth dental problems	0.7	1.0	2.3	-1.4	0.7	0.7	1.1	-1.3	-0.2	1.1	0.8	1.5	0.0	1.2
Heart attack	1.9	2.5	4.9	-1.7	2.2	1.3	2.0	-0.9	1.8	1.7	1.9	0.8	1.0	1.1
Allergy	68.7	158.1	259.2	15.4	-14.7	-9.9	-9.5	12.9	-12.9	-16.1	-14.4	-11.0	-5.2	-12.2
Pain all over the body in last month	0.3	0.4	1.3	-0.7	1.2	0.0	-0.2	-0.5	0.7	1.0	0.3	0.6	-0.1	0.2
Diabetes (self-reported)	0.3	0.5	2.9	0.6	-0.4	0.3	0.0	1.7	-0.5	-0.5	-0.3	-0.3	0.6	-0.8
Hayfever/allergic rhinitis (self-reported)	31.5	41.7	68.4	-8.0	7.5	6.1	4.7	-6.8	6.2	8.3	6.8	6.0	3.2	5.6
Medication: Ramipril	0.7	0.9	3.2	1.0	-0.3	-0.0	1.6	1.8	-0.4	-0.9	-0.5	-0.6	-0.5	-1.2
Medication: Simvastatin	0.5	0.8	1.9	-1.0	1.4	1.0	1.1	0.1	0.8	0.9	0.4	0.6	-0.8	1.1
Fluid intelligence score	0.4	0.7	2.5	-0.5	0.9	0.4	0.5	-1.6	-0.4	0.5	0.5	0.4	1.5	0.8
Illnesses of siblings	0.9	1.3	7.9	0.0	-0.4	0.2	-2.8	-0.4	0.0	-0.0	0.4	1.1	1.7	1.1
Neuroticism score	0.3	0.6	2.0	-1.0	0.6	0.3	-0.9	-0.4	1.4	1.2	0.3	-0.4	0.1	0.6
Weight	1.1	5.5	21.4	2.6	-1.1	0.2	-1.0	1.9	-2.5	-3.0	-2.2	-2.5	0.5	-4.6
Impedance of arm (right)	0.1	0.5	1.6	0.1	-0.2	-1.2	0.6	-1.3	0.4	-0.0	-0.3	-0.1	0.8	0.9
Arm fat percentage (right)	0.8	3.2	6.6	2.1	-1.2	-0.5	-0.3	2.2	-2.5	-2.2	-1.4	-2.0	-0.2	-2.6
Trunk fat-free mass	0.4	2.1	12.5	1.1	-0.0	0.6	-1.3	0.4	-1.2	-1.5	-1.1	-0.9	1.1	-3.5
Hip circumference	2.2	9.4	28.8	3.4	-2.1	-1.3	-1.7	2.4	-3.7	-3.9	-3.2	-2.8	-0.1	-5.4
Time employed in main current job	0.4	0.5	1.6	-0.4	0.8	-0.6	0.8	-1.2	0.6	0.5	0.6	0.8	0.6	0.3
Alcohol intake versus 10 years previously	0.4	0.6	2.0	-0.1	0.1	1.2	-1.2	1.4	0.1	0.1	0.3	-0.6	-0.7	-0.1
Father’s age at death	0.2	0.3	1.3	0.1	-0.7	-0.5	-1.2	-0.7	-0.1	0.0	0.1	-0.6	-0.7	0.2
Worrier / anxious feelings	0.2	0.4	1.6	-0.7	0.3	0.5	-0.6	-0.7	1.2	0.5	-0.2	0.5	-0.7	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	7.1	1.3	-1.4	-0.8	-1.2	1.8	-1.3	-1.2	-1.3	-2.7	-1.3	-1.2
Falls in the last year	0.4	0.6	4.6	0.8	-0.5	-2.1	-0.0	0.1	-0.5	-0.3	0.1	-0.7	-0.6	-0.1
Hair/balding pattern: Pattern 3	0.6	0.8	5.7	-0.0	0.2	-0.9	0.6	1.0	-0.0	0.3	-0.2	0.4	-2.4	1.1
Number of live births	1.4	2.0	3.3	1.7	-1.8	-0.1	-1.7	1.7	-1.2	-1.7	-1.4	-0.0	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.3	2.0	-1.6	-0.3	-1.1	1.0	-1.4	-2.1	-0.9	-1.2	0.6	-1.8
Pulse rate	1.7	2.8	5.6	-2.0	1.9	2.4	1.0	-1.6	1.6	2.1	1.9	0.9	1.3	1.2
Happiness	1.9	2.4	6.0	2.2	-2.5	-1.7	-1.6	1.4	-0.6	-2.0	-1.4	-1.2	0.1	-0.1
Noisy workplace	0.6	0.8	2.2	0.9	-0.7	-1.1	-0.0	1.5	-0.1	-0.7	-0.8	-1.3	-1.0	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.3	0.3	-0.1	1.8	-1.0	-1.6	0.2	-0.3	0.3	-0.6	1.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.1	-0.2	0.3	-0.5	0.3	-1.1	-0.8	0.4	0.5	0.1	0.1	0.2
Mouth/teeth dental problems: Dentures	0.9	1.5	5.4	-1.0	1.4	0.7	0.2	0.6	2.3	1.5	1.4	0.0	-0.5	1.8
Asthma	18.5	36.5	57.9	-7.3	7.1	5.5	5.0	-5.1	6.1	7.6	7.3	5.5	2.3	5.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.2	0.8	-1.7	0.6	-1.8	0.1	-0.8	-0.9	-0.5	0.1	0.3	0.2
Medication: Cholesterol lowering	0.2	0.3	2.3	0.2	0.2	0.1	0.0	1.5	-0.4	-0.3	-0.1	0.2	-0.1	-0.1
Depression (self-reported)	0.5	0.7	3.5	0.8	-0.7	-0.6	-1.9	0.1	-0.2	-0.8	-1.0	-0.7	0.6	0.0
Medication: Lansoprazole	2.2	2.5	6.4	-1.6	1.5	2.5	1.6	-1.4	1.4	1.8	1.6	1.0	0.6	1.5
Prospective memory result	1.1	1.4	2.5	-1.5	1.4	0.6	1.3	-1.2	1.2	1.6	1.2	0.3	0.1	1.4
Lung cancer (father)	0.6	0.7	2.9	0.4	-0.1	-0.3	1.2	-0.5	-1.7	-0.4	0.3	-0.2	0.9	-1.2
Illnesses of mother	1.3	1.6	3.7	1.2	-1.7	-1.9	-1.3	1.2	-0.7	-1.2	-1.4	-1.3	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.5	1.0	-0.6	-0.1	-0.6	0.5	-0.3	-1.1	-0.1	-0.3	1.2	-1.0
Pulse wave Arterial Stiffness index	2.9	3.4	8.1	-2.6	2.1	2.8	0.8	-1.9	1.1	2.5	1.9	1.0	0.6	1.2
Impedance of arm (left)	0.1	0.5	2.2	0.7	-0.7	-1.5	0.8	-0.5	-0.1	-0.7	-0.9	-0.8	0.3	0.2
Arm fat mass (right)	1.0	4.2	13.2	2.3	-1.1	-0.1	-0.6	2.1	-2.6	-2.5	-1.7	-2.3	0.0	-3.6
Trunk predicted mass	0.4	2.3	12.7	1.2	-0.2	0.5	-1.4	0.6	-1.3	-1.6	-1.3	-1.0	1.1	-3.6
Standing height	0.4	3.7	18.0	1.7	-0.5	0.2	-0.9	-0.4	-0.7	-2.3	-1.9	-1.8	2.3	-4.2
Length of working week for main job	1.3	1.5	3.6	1.3	-1.4	-1.9	-0.9	0.5	-1.3	-1.0	-0.8	-1.7	-0.6	-1.1
Exposure to tobacco smoke at home	0.5	0.6	2.1	0.8	-1.0	-0.9	-0.5	1.5	-0.5	-0.8	-0.7	-0.4	-0.3	0.4
Breastfed as a baby	2.0	2.4	4.9	2.2	-2.1	-1.1	-1.8	1.0	-1.8	-2.2	-0.9	-1.1	0.7	-1.2
Tense / ‘highly strung’	0.7	1.1	4.4	0.9	-0.9	0.3	-1.6	0.8	0.4	-0.4	-1.2	-2.1	-1.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.6	0.9	-0.7	-0.4	-0.1	0.6	0.4	0.3	0.3	1.0	0.6
Hair/balding pattern: Pattern 4	0.3	0.7	1.9	0.1	1.3	0.1	1.4	-0.6	1.1	0.2	-0.0	0.2	1.1	-1.2
Birth weight of first child	0.4	0.7	2.2	-0.8	0.5	-0.9	-0.2	-1.1	-0.1	0.7	0.9	0.5	1.5	0.9
Peak expiratory flow (PEF)	0.2	0.4	1.2	0.2	-0.6	-0.9	-0.9	0.5	-0.6	-0.4	0.7	0.2	1.1	-0.3
Pulse wave reflection index	0.8	1.0	2.3	-1.4	0.7	0.9	0.5	-0.8	0.4	1.5	1.4	0.6	-0.6	1.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	4.6	0.8	-0.5	-1.0	0.7	2.2	-0.3	-0.3	0.3	-0.7	-0.3	1.3
Loud music exposure frequency	0.2	0.2	0.8	0.3	0.0	-0.8	0.2	0.2	-0.8	-0.2	-0.3	0.1	-0.9	0.1
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	7.0	2.7	-1.8	-1.2	-1.2	1.3	-1.8	-2.6	-1.9	-1.5	0.4	-1.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	5.1	0.9	-0.5	-2.3	-0.4	-1.1	-0.9	-0.8	-0.9	-0.4	-0.3	-1.9
Blood clot in the leg (DVT)	0.5	0.7	1.9	0.8	-0.9	-0.9	-1.0	0.5	-0.6	-0.6	-0.5	-1.4	0.7	-0.6
Medication: Paracetamol	1.1	1.9	4.3	-2.0	1.4	0.6	0.9	-1.3	0.6	1.8	1.5	1.1	0.4	2.1
Headache pain in last month	0.8	1.3	3.9	1.2	-1.3	-0.3	-1.1	1.0	-0.0	-1.2	-1.6	-0.9	-2.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.0	-0.3	-0.2	-0.5	-1.3	-1.7	-0.3	0.4	-0.1	-0.6	-1.1	0.3
Glaucoma (self-reported)	1.5	1.7	3.8	1.7	-1.4	-1.0	-0.3	0.4	-1.1	-1.9	-1.7	-0.1	-1.1	-2.0
Gout (self-reported)	0.4	0.6	3.1	0.2	0.1	1.8	1.5	0.1	0.6	-0.2	-0.2	-0.5	0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	8.0	2.7	-2.5	-0.7	-0.7	1.7	-1.7	-2.8	-2.6	-2.4	-1.3	-2.8
Medication: Amlodipine	0.8	1.2	5.4	-0.9	1.6	0.8	2.3	0.8	1.4	0.6	0.4	0.5	0.4	-0.5
Medication: Ventolin 100micrograms inhaler	10.6	13.6	20.8	-4.3	4.1	4.1	2.8	-4.3	3.1	4.6	4.3	2.7	1.9	3.3
Birth weight	0.5	1.1	4.9	-0.4	0.5	-2.2	-0.2	-1.9	0.7	0.6	1.1	0.1	0.5	1.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	5.3	-0.4	0.8	2.3	0.5	-0.1	0.6	0.6	0.3	-0.3	0.3	0.7
High blood pressure (siblings)	0.4	0.6	2.5	-0.8	1.0	0.8	1.6	0.4	-0.3	0.6	0.4	-0.6	-1.0	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	1.7	-0.0	0.3	1.2	0.1	-0.1	0.5	-0.1	0.7	0.2	1.3	0.0
Body fat percentage	0.8	3.0	8.1	1.9	-0.7	0.1	0.3	2.0	-2.1	-2.1	-1.5	-2.3	-0.4	-2.8
Leg fat percentage (right)	0.3	1.1	3.4	0.8	0.3	1.4	0.6	1.1	-1.2	-0.8	-0.6	-1.3	-0.7	-1.9
Arm fat-free mass (right)	0.6	3.0	14.9	1.6	-0.5	0.4	-1.4	1.1	-1.7	-2.0	-1.4	-1.6	0.6	-3.9
Exposure to tobacco smoke outside home	0.4	0.5	1.9	0.3	-0.3	-1.4	0.3	0.7	-0.1	-0.4	-0.8	-1.0	-0.9	-0.2
Comparative body size at age 10	1.3	3.6	5.4	2.2	-2.2	-2.2	-2.3	1.9	-1.9	-2.2	-1.7	-1.2	-1.2	-1.2
Number of full brothers	0.1	0.2	1.0	0.4	-0.2	0.5	-0.4	1.0	-0.4	-0.1	0.2	0.0	-0.1	0.4
Worry too long after embarrassment	0.2	0.3	1.0	0.5	-0.6	-0.4	-0.4	1.0	0.0	-0.7	-0.7	-0.6	0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.8	0.9	-1.1	-1.6	-1.5	1.8	-1.3	-1.0	-0.7	-2.2	-1.1	-0.9
Wheeze or whistling in the chest in last year	4.7	8.3	14.0	-3.3	3.7	3.4	2.3	-2.6	3.5	3.6	2.9	1.4	-0.3	2.7
Number of children fathered	0.2	0.2	1.2	-0.4	0.3	-0.5	-0.1	-0.1	-0.1	0.3	-0.3	-1.1	0.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	3.2	0.2	0.1	0.4	0.1	-1.8	0.7	0.0	-0.4	-1.1	-0.8	-0.3
Age at first live birth	0.7	1.2	5.1	-1.0	0.7	-1.2	0.2	-2.3	0.7	1.1	0.7	0.4	1.0	1.3
Pulse wave peak to peak time	3.1	3.6	7.7	2.7	-2.1	-2.8	-0.9	1.9	-1.1	-2.7	-2.0	-1.1	-0.2	-1.5
Health satisfaction	0.8	1.0	2.4	1.1	-1.1	-0.7	-1.1	1.5	-1.0	-0.6	-0.6	-1.6	-1.0	-0.0
Shortness of breath walking on level ground	1.8	2.1	3.8	1.9	-1.3	-0.5	-1.7	1.9	-0.7	-1.7	-1.6	-1.8	-0.8	-1.2
Qualifications: College or University degree	1.4	4.5	12.6	-1.9	1.9	2.6	-0.8	-3.5	1.3	1.7	1.7	1.5	3.5	0.8
Eye problems/disorders: None of the above	0.4	0.5	1.5	0.5	-0.6	1.0	-0.6	1.2	-0.2	-0.4	-0.6	-1.0	-0.0	0.4
Mouth/teeth dental problems: Loose teeth	3.4	4.1	8.9	2.5	-2.4	0.0	-2.4	3.0	-0.8	-2.6	-2.4	-1.1	-0.3	-1.8
Emphysema/chronic bronchitis	1.1	1.3	8.0	-0.4	0.5	2.8	-1.5	-0.6	0.3	0.7	0.5	-0.1	0.4	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.7	-0.4	0.0	0.3	-0.8	-0.4	-0.5	-0.1	-1.0	1.0	-1.0
Neck or shoulder pain in last month	0.8	1.1	2.8	1.1	-0.9	-1.1	-0.2	1.2	-0.4	-1.0	-1.5	-0.8	-1.7	-0.8
Medication: Blood pressure	0.5	0.9	2.9	-0.2	0.6	1.2	1.6	1.7	0.9	0.1	0.5	0.7	0.9	0.2
Angina (self-reported)	0.3	0.4	1.3	-0.4	0.7	-0.1	1.2	0.9	0.2	0.6	0.4	0.2	-0.9	0.2
Migraine (self-reported)	0.7	0.9	2.7	1.2	-1.6	-0.6	-0.8	1.0	-0.5	-1.2	-0.6	-1.1	-0.3	-0.7
Medication: Ibuprofen	0.5	0.6	2.6	0.7	-1.5	0.5	-1.6	-0.0	-0.3	-0.6	-0.0	-0.3	0.6	0.8
Medication: Allopurinol	0.5	0.7	1.5	0.6	-1.1	1.1	0.6	1.2	-0.5	-0.8	-0.5	-0.9	-1.0	-0.6
Medication: Omeprazole	2.2	2.6	5.9	1.6	-1.3	-0.0	-2.4	2.2	-1.4	-1.8	-1.7	-0.8	-1.2	-1.9
Medication: Seretide 50 evohaler	2.9	3.4	16.0	-1.7	2.3	4.0	2.0	-1.6	1.2	1.4	1.1	0.5	0.8	0.8
Mean time to correctly identify matches	0.4	0.8	4.5	-0.4	0.8	-2.1	0.5	0.7	0.8	0.7	0.4	-0.4	-0.9	0.8
Heart disease (mother)	3.3	4.0	8.5	-2.6	2.9	2.2	1.0	-1.6	1.8	2.5	2.1	2.0	1.1	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.3	-0.5	0.3	-1.8	0.9	-0.9	1.0	0.7	0.5	-0.2	-1.5	0.9
Whole body fat mass	0.9	3.9	13.5	2.1	-0.8	0.1	-0.1	2.1	-2.3	-2.4	-1.6	-2.5	-0.0	-3.7
Leg fat mass (right)	0.8	2.9	10.0	1.8	-0.5	0.7	-0.0	2.0	-2.0	-1.9	-1.3	-2.1	-0.3	-3.2
Arm predicted mass (right)	0.6	2.8	14.4	1.6	-0.4	0.5	-1.2	1.2	-1.5	-2.0	-1.4	-1.5	0.7	-3.8
Pulse rate, automated reading	0.6	2.0	3.8	-1.9	1.4	1.8	0.7	-0.8	1.2	2.0	1.7	0.7	0.4	1.8
Alcohol intake frequency.	1.8	4.3	6.9	2.1	-2.0	-2.2	-2.6	2.4	-2.1	-2.4	-1.9	-1.3	-0.4	-2.3
Comparative height size at age 10	0.1	0.6	1.5	-0.6	0.9	0.4	0.7	-1.2	0.9	0.3	0.3	-0.1	0.8	-1.1
Number of full sisters	0.1	0.1	0.7	0.2	0.6	0.8	-0.3	0.0	0.1	-0.2	-0.1	0.5	-0.0	-0.4
Suffer from ‘nerves’	0.2	0.2	0.8	-0.6	-0.1	-0.2	0.6	0.3	0.9	0.4	-0.2	0.4	0.6	0.5
Overall health rating	0.2	0.5	1.9	0.0	0.6	-0.0	0.1	0.7	-1.4	-0.0	0.0	-0.9	-0.5	-1.3
Chest pain or discomfort	1.8	2.6	5.6	-1.6	1.9	2.4	1.4	-1.1	2.0	1.8	1.4	1.5	0.5	1.5
Had major operations	0.9	1.0	1.8	-1.2	1.3	0.1	1.1	-0.0	1.3	1.1	0.6	1.3	-1.0	1.0
Age at last live birth	0.8	1.1	5.8	0.1	-0.3	-2.4	-1.3	-1.5	0.6	0.3	0.4	0.2	-0.5	1.2
Family relationship satisfaction	0.6	0.7	2.5	0.8	-1.6	-1.3	0.0	1.4	-0.3	-0.6	-0.4	-0.4	-0.6	0.1
Leg pain on walking	2.1	2.6	5.1	1.9	-1.9	-1.4	-1.2	2.2	-0.9	-1.6	-1.3	-1.9	-1.6	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.6	0.5	-0.9	-1.0	-0.2	0.1	-0.7	-0.5	0.1	0.3	0.5	-1.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.1	-0.1	-0.3	0.3	0.8	-0.9	0.0	-0.2	-0.1	-0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.4	0.7	0.3	-0.6	-0.6	0.7	0.1	-0.3	0.8	0.7	0.6
Medication: Aspirin	0.8	1.0	2.9	-1.0	1.7	0.8	0.6	0.4	1.5	1.0	0.7	1.1	-0.1	1.0
Supplements: Vitamin C	0.6	0.8	3.3	-0.7	0.3	-0.5	0.2	0.3	1.2	0.5	0.1	1.8	0.5	1.5
Knee pain experienced in last month	0.7	1.1	4.7	0.9	-0.3	-0.5	0.8	1.1	-0.4	-1.2	-1.1	-1.0	0.0	-2.2
Hypertension (Self-reported)	0.3	1.0	4.6	0.2	0.7	1.1	1.7	2.1	0.3	-0.5	-0.2	-0.0	-0.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.3	0.0	0.1	0.8	1.5	0.0	0.8	0.1	0.1	-0.1	-1.4	-0.1
Illnesses of father: Heart disease	0.2	0.3	1.7	-0.0	0.6	0.2	0.1	1.3	-0.3	0.0	-0.1	0.3	0.8	0.7
Illnesses of siblings: Diabetes	0.8	1.0	3.6	0.7	-1.0	-0.6	1.0	1.9	-0.9	-0.7	-0.8	-0.7	-0.2	-1.2
Smoking status: Previous	0.4	0.6	1.5	0.4	-0.0	-1.2	0.9	0.8	0.9	0.1	-0.4	-0.4	-1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	1.1	-0.4	0.3	-0.1	0.6	0.1	-1.0	-0.7	-0.8	0.9	-1.0
Whole body fat-free mass	0.5	3.0	14.6	1.6	-0.5	0.1	-1.5	1.0	-1.7	-2.1	-1.5	-1.4	1.2	-3.8
Leg fat-free mass (right)	1.0	5.4	16.3	2.6	-1.5	-0.8	-1.8	1.9	-2.5	-3.0	-2.0	-2.1	1.4	-4.0
Arm fat percentage (left)	1.1	4.3	9.9	2.4	-1.4	-0.7	-0.3	2.3	-2.8	-2.6	-1.8	-2.5	-0.3	-3.1
Average weekly red wine intake	0.9	1.4	2.8	-1.1	1.4	1.2	1.4	-1.7	1.1	1.1	0.8	0.9	1.4	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.5	0.3	-0.9	-0.9	-0.5	0.0	-0.9	-0.5	-0.4	-0.9	-1.6	-0.1
Mood swings	0.6	1.0	2.3	-1.4	1.0	0.8	-0.1	-0.5	1.2	1.5	1.2	0.7	-0.4	1.3
Loneliness, isolation	0.5	0.7	2.9	-0.6	0.2	0.6	-1.0	-0.4	0.5	1.1	1.0	-0.9	-0.4	1.7
Long-standing illness, disability or infirmity	0.5	0.7	2.7	-0.7	1.2	1.6	0.1	-0.6	0.8	0.7	0.7	-0.2	0.9	-0.2
Ever had bowel cancer screening	0.3	0.3	1.2	-0.1	0.9	0.5	1.0	-0.3	1.1	0.3	0.0	0.2	-0.2	0.3
Diabetes diagnosed by doctor	0.5	0.7	4.3	0.9	-0.7	0.4	0.5	2.1	-0.4	-0.7	-0.4	-0.6	0.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.6	0.3	-0.6	-1.4	-1.6	-0.2	-1.5	-0.0	0.5	-0.5	0.1	0.6
Friendships satisfaction	0.7	0.8	3.2	0.5	-1.4	-0.7	-1.6	0.4	0.4	0.1	0.6	0.3	0.2	1.8
Qualifications: nursing, teaching	0.2	0.3	1.2	0.7	-0.3	0.7	0.1	0.4	-0.2	-0.6	-0.3	-0.6	-1.1	0.5
Commuting to job workplace: Walk	1.0	1.1	2.3	-1.4	0.9	0.2	-0.1	-1.4	1.5	1.1	1.0	1.3	0.5	1.0
Eye problems/disorders: Cataract	0.3	0.4	1.7	-0.4	0.4	-0.6	0.3	-1.3	-0.0	0.2	0.5	0.3	1.1	0.2
Mouth/teeth dental problems: Mouth ulcers	4.3	6.9	10.2	3.2	-3.1	-0.8	-2.9	2.3	-2.9	-3.2	-2.4	-2.9	0.5	-3.0
Medication for cholesterol	0.1	0.1	0.3	0.3	-0.5	-0.6	-0.1	-0.2	-0.4	-0.3	0.1	0.1	0.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.6	-0.2	0.1	0.4	-0.3	-0.1	0.5	0.2	-0.3	0.8	-0.2	0.5
Back pain experienced in last month	1.0	1.5	3.1	1.1	-1.2	-1.8	-0.9	1.2	-0.9	-0.8	-1.6	-1.8	-1.2	-0.6
Mineral and other dietary supplements	0.7	1.0	2.3	0.5	-1.5	0.2	-1.1	0.6	-1.3	-0.6	-1.0	-1.1	-1.5	0.2
Breast cancer (self-reported)	4.7	5.7	10.1	2.9	-2.3	-2.0	-1.1	3.1	-1.6	-3.2	-3.0	-1.9	-1.0	-2.8
Asthma (self-reported)	18.3	36.4	57.1	-7.4	6.9	5.5	4.8	-5.1	6.0	7.6	7.3	5.6	2.7	5.9
Osteoporosis (self-reported)	0.4	0.5	1.3	-0.3	0.5	1.1	-0.1	-0.9	0.6	0.2	0.6	0.3	1.2	1.1
Osteoarthritis (self-reported)	1.1	1.4	2.7	1.3	-0.8	-1.7	-0.3	1.1	-0.9	-1.4	-1.5	-1.0	-0.7	-1.5
Medication: Aspirin	0.5	0.7	2.1	-0.7	1.5	0.5	1.1	0.8	0.9	0.5	0.5	1.1	-0.6	0.5
Medication: Gliclazide	0.8	0.9	3.4	-0.2	0.6	1.8	-0.1	0.6	-1.0	-0.1	0.5	0.4	1.7	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.5	-0.9	0.3	-0.2	-0.2	-0.5	0.7	1.1	0.5	0.8	-1.6	1.1
Smoking status: Current	0.3	0.5	1.1	0.1	-0.3	1.1	-0.3	1.0	-1.0	-0.0	0.3	-0.3	-0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	-0.3	0.7	0.3	0.2	-0.9	-0.0	0.2	0.7	0.4	0.8	-0.2
Whole body water mass	0.6	3.4	15.7	1.8	-0.6	0.0	-1.5	1.1	-1.8	-2.2	-1.6	-1.5	1.2	-4.0
Leg predicted mass (right)	1.0	5.4	16.4	2.6	-1.6	-0.8	-1.9	1.9	-2.5	-3.0	-2.0	-2.1	1.4	-4.0
Arm fat mass (left)	1.2	4.8	14.9	2.4	-1.2	0.0	-0.6	2.2	-2.9	-2.7	-1.8	-2.5	0.1	-3.9
Number of self-reported non-cancer illnesses	1.4	2.4	7.4	-1.6	1.7	2.7	1.2	-0.8	1.6	1.6	1.4	1.3	1.2	0.9
Average weekly champagne plus white wine intake	0.9	1.3	3.9	-1.0	1.2	0.1	0.6	-1.0	1.2	1.2	1.3	1.2	0.6	2.0
Miserableness	0.2	0.3	1.1	-0.7	0.5	0.2	-1.0	-0.2	0.6	0.6	-0.2	-0.4	-0.8	0.3
Guilty feelings	1.9	2.8	7.2	1.5	-1.2	-1.2	-2.4	-0.2	-2.1	-1.4	-1.5	-2.7	-0.3	-2.0
Wears glasses or contact lenses	2.8	3.2	7.1	-1.8	2.7	0.9	1.9	-2.3	1.5	1.3	1.4	2.0	1.9	1.0
Ever taken oral contraceptive pill	0.4	0.4	1.7	0.5	-0.2	1.3	-1.3	0.5	-0.6	-0.2	-0.1	0.4	-0.2	0.2
Hearing aid user	1.1	1.3	2.5	-1.2	1.4	-0.7	0.3	-1.6	1.4	1.3	0.8	1.4	-0.1	1.0
Mother’s age at death	0.0	0.0	0.1	0.4	-0.2	-0.1	-0.1	0.1	0.1	-0.3	0.2	0.1	0.2	-0.0
Financial situation satisfaction	0.3	0.3	1.3	0.6	-0.5	-0.0	-0.1	0.8	-0.5	0.1	0.5	-0.5	-0.6	1.1
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.8	-0.9	1.3	1.3	1.3	-1.1	1.0	0.8	1.1	-0.5	0.0	-1.1
Commuting to job workplace: Public transport	0.3	0.3	1.6	-0.0	0.2	-0.6	0.1	-1.3	0.2	0.2	0.8	-0.7	0.4	0.2
Eye problems/disorders: Glaucoma	2.1	2.5	5.6	2.0	-1.6	-1.2	-0.7	0.9	-0.7	-2.0	-2.4	-0.7	-2.0	-1.8
Medication: Blood pressure	0.6	1.2	4.7	-1.0	2.2	1.0	1.5	0.3	0.8	0.7	-0.1	-0.2	-1.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.7	0.0	-0.4	-0.7	0.2	0.7	0.1	0.1	0.4	-0.9	0.0	0.3
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.8	-0.9	1.7	-0.1	1.4	-0.5	1.5	1.0	1.2	1.9	1.4	0.5
High cholesterol (Self-reported)	0.3	0.6	1.6	-0.7	1.1	0.7	0.5	0.6	0.9	0.8	0.2	0.4	-0.9	1.3
Medication: Bendroflumethiazide	0.4	0.6	1.8	-0.2	0.7	0.8	1.3	1.2	0.4	-0.0	-0.3	-0.7	-0.7	-1.2
Medication: Paracetamol	0.9	1.4	4.1	-1.5	1.3	0.4	1.2	-1.1	0.6	1.5	1.3	0.7	0.2	2.0
Medication: Lisinopril	0.8	1.0	3.6	1.0	-0.9	-0.7	-0.5	1.9	0.4	-0.9	-1.5	-0.9	-0.8	-0.8
Medication: Atorvastatin	0.1	0.1	0.6	-0.1	0.6	0.0	-0.5	0.1	0.4	0.1	-0.1	0.3	0.8	-0.3
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.1	0.6	0.5	-0.5	0.1	0.2	-0.1	-0.1	-0.5	0.6	-0.2
Alcohol drinker status: Never	3.4	4.0	9.8	2.1	-1.5	-1.6	0.2	1.9	-1.5	-2.5	-2.4	-1.1	-2.4	-3.1
Ever smoked	0.4	0.8	1.9	1.2	-0.9	-0.7	-0.5	1.4	0.2	-0.6	-0.8	-0.8	-1.0	0.9
Basal metabolic rate	0.7	3.9	17.7	2.0	-0.7	0.1	-1.4	1.2	-2.0	-2.4	-1.7	-1.8	1.1	-4.2
Leg fat percentage (left)	0.4	1.3	4.3	1.0	0.1	1.3	0.2	1.4	-1.2	-1.0	-0.7	-1.4	-0.6	-2.1
Arm fat-free mass (left)	0.6	3.1	15.1	1.8	-0.6	0.5	-1.6	1.1	-1.7	-2.1	-1.5	-1.4	0.8	-3.9
Number of operations (self-reported)	1.3	1.9	4.1	1.6	-1.5	-1.7	0.4	2.0	-0.7	-1.6	-1.8	-0.6	-1.0	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.3	-0.5	0.3	1.5	-0.0	0.3	0.5	0.8	1.2	0.6	0.4	1.2
Irritability	2.2	3.7	8.7	-2.1	2.4	1.3	0.7	-2.9	2.2	2.7	2.0	-0.5	0.8	1.5
Risk taking	0.8	1.2	3.5	0.7	-1.2	-0.0	-1.8	0.9	-0.2	-0.4	-0.7	-1.8	-1.9	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.2	0.2	-0.4	-0.2	0.3	0.0	0.1	-0.2	0.5	-0.1	0.5
Fractured/broken bones in last 5 years	0.5	0.6	3.4	-0.6	0.1	-1.9	0.9	-0.1	-0.4	0.9	0.6	-0.0	-0.3	1.0
Age started oral contraceptive pill	0.5	0.6	1.8	0.1	-0.2	-0.7	-0.7	1.0	0.7	-0.1	-0.5	-1.3	-1.2	-0.6
Diastolic blood pressure, automated reading	0.4	1.2	4.7	-1.1	1.2	1.6	2.2	-0.2	1.0	0.9	0.9	0.6	0.2	0.1
Ever depressed for a whole week	0.5	0.6	2.1	0.2	0.5	-1.0	1.0	0.2	1.1	0.0	0.0	0.3	-0.9	1.4
Unable to work because of sickness or disability	0.8	1.0	3.6	1.2	-0.6	-0.7	-1.9	1.4	-1.2	-1.2	-0.5	-0.3	-0.6	-0.3
Commuting to job workplace: Cycle	0.9	1.0	2.5	0.6	-1.1	0.7	-1.3	1.3	0.2	-0.6	0.5	0.9	1.5	1.6
Myopia	0.1	0.2	0.5	-0.5	-0.1	-0.2	0.7	0.4	0.0	0.6	0.3	0.6	0.0	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.8	-0.2	-1.0	-1.2	-1.7	-1.4	-0.7	0.4	0.4	-0.1	-0.0	1.2
Cholesterol lowering medication	0.7	1.0	3.5	-1.0	1.4	0.6	1.0	-1.0	1.9	1.1	-0.0	-0.2	-1.0	0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.0	1.3	-0.8	-0.5	-1.3	2.2	-0.8	-1.3	-1.2	-0.4	-1.3	-1.7
Pain experienced in last month	2.6	4.3	7.6	-2.3	2.0	2.0	0.2	-2.5	1.4	2.1	2.3	2.0	2.8	2.1
Supplements: Calcium	0.5	0.6	3.2	-0.4	0.6	0.3	0.3	-0.5	0.6	0.4	1.2	0.1	1.8	0.7
Basal cell carcinoma (self-reported)	1.7	2.1	7.7	1.6	-1.4	-2.8	-1.1	1.6	-1.4	-1.6	-1.0	-0.6	0.1	-0.7
Heart attack/myocardial infarction (self-reported)	2.4	3.1	5.9	-2.0	2.4	1.7	2.1	-1.1	2.0	2.0	2.2	0.8	1.0	1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.4	1.1	-1.1	-1.1	-1.3	0.7	-0.8	-0.9	-0.8	-1.6	0.5	-1.0
Heart disease (siblings)	0.2	0.3	1.6	0.0	-0.5	0.3	0.8	0.1	-0.2	-0.2	-0.3	-0.2	0.2	-1.3
Alcohol drinker status: Previous	0.4	0.4	1.0	0.8	-0.7	-0.9	-0.3	0.9	-0.4	-0.8	-0.0	-0.2	0.2	-1.0
Pack years of smoking	0.3	0.4	1.5	0.8	-0.7	-1.2	-0.8	0.7	-0.1	-0.7	-0.2	-0.6	-0.3	0.5
Impedance of whole body	0.1	0.4	1.3	-0.4	-0.0	0.4	0.9	-1.0	0.9	0.5	0.1	0.0	0.2	1.1
Leg fat mass (left)	0.8	3.0	10.0	1.8	-0.6	0.7	-0.3	2.1	-2.0	-2.0	-1.3	-2.0	-0.2	-3.2
Arm predicted mass (left)	0.8	4.0	16.9	2.1	-1.0	0.5	-1.7	1.5	-1.9	-2.4	-1.7	-1.8	0.8	-4.1