TWAS hub - TLR6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0410	1.3e-05	0.051	0.053	0.076	0.084	0.076	6.7e-07	4.9e-07	1.4e-09	2.1e-10	1.7e-09
2	GTEx	Cells Transformed fibroblasts	0.2830	0.0600	4.4e-09	0.188	NA	0.139	NA	0.166	4.5e-14	NA	1.3e-10	NA	1.7e-12
3	GTEx	Esophagus Mucosa	0.3610	0.0750	1.0e-05	0.063	NA	0.113	NA	0.120	5.0e-05	NA	5.8e-08	NA	2.3e-08
4	GTEx	Skin Not Sun Exposed Suprapubic	0.2890	0.0700	7.5e-06	0.032	NA	0.041	NA	0.078	7.2e-03	NA	2.6e-03	NA	4.8e-05
5	GTEx	Skin Sun Exposed Lower leg	0.1670	0.0480	3.0e-05	0.117	NA	0.097	NA	0.099	6.6e-10	NA	1.9e-08	NA	1.6e-08
6	YFS	Blood	0.0452	0.0159	1.2e-06	0.044	0.018	0.039	0.059	0.043	3.7e-14	1.0e-06	6.6e-13	1.3e-18	5.8e-14
7	TCGA	Colon Adenocarcinoma	0.1570	0.0910	1.6e-03	0.030	0.052	0.064	NA	0.060	7.6e-03	5.4e-04	1.5e-04	NA	2.2e-04
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0335	0.0220	7.7e-03	0.017	0.002	0.000	NA	0.008	4.7e-03	2.0e-01	3.7e-01	NA	3.5e-02
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0442	0.0222	2.8e-04	0.039	0.033	0.023	NA	0.035	2.9e-05	1.1e-04	1.2e-03	NA	6.6e-05
10	TCGA	Pancreatic Adenocarcinoma	0.1040	0.0530	1.1e-03	0.126	0.054	0.092	NA	0.103	6.2e-06	2.7e-03	1.2e-04	NA	4.4e-05
11	TCGA	Prostate Adenocarcinoma	0.0697	0.0513	4.5e-03	0.017	0.008	0.002	NA	0.006	6.2e-03	4.7e-02	1.7e-01	NA	7.3e-02
12	TCGA	Thyroid Carcinoma	0.0640	0.0310	1.4e-03	0.041	0.024	0.035	NA	0.039	6.4e-05	1.9e-03	2.3e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Allergy or Eczema	48.6	127.9	316.8	-6.3	17.8	-0.0	16.1	10.5	17.6	2.6	17.6	4.8	6.4	-9.1	-6.0
Hayfever, allergic rhinitis or eczema	39.8	86.3	210.2	-5.3	14.4	0.7	13.3	9.0	14.5	2.2	14.2	3.9	5.6	-7.3	-5.1
Allergy	33.5	77.2	187.7	4.6	-13.7	-1.7	-12.7	-8.8	-13.3	-2.8	-13.5	-4.7	-5.8	6.2	3.8
Hayfever/allergic rhinitis (self-reported)	17.1	22.7	58.4	-3.5	7.5	0.9	6.7	4.7	7.1	0.6	7.6	2.4	3.1	-3.2	-1.0
Respiratory disease	10.0	22.3	53.3	-1.5	7.3	1.2	7.1	5.1	6.4	2.4	7.2	3.2	3.5	-3.4	-0.4
Asthma	8.9	17.5	42.7	-2.0	6.5	1.4	6.3	4.6	5.6	2.0	6.4	2.8	3.1	-2.6	-0.1
Asthma (self-reported)	8.3	16.5	41.8	-1.8	6.5	1.1	6.1	4.2	5.8	1.7	6.3	2.4	2.7	-2.9	-0.3
Medication: Ventolin 100micrograms inhaler	4.8	6.1	17.4	-1.4	4.1	0.1	3.5	2.2	3.3	0.8	4.2	1.6	1.4	-1.8	-0.6
Breast Cancer	4.7	11.3	32.6	1.0	5.5	-1.5	3.5	1.3	5.7	-2.2	5.6	-0.9	-0.1	-3.8	-1.9
Blood Eosinophil Count	4.4	34.1	70.9	-5.1	-1.7	7.2	4.4	6.8	-2.4	7.5	-1.4	8.4	8.0	6.6	4.5
Medication: Blood pressure	3.5	6.7	15.8	-2.0	1.8	4.0	3.1	3.4	1.1	1.8	1.9	3.1	3.6	1.5	1.8
Commuting to job workplace: Cycle	3.4	4.1	8.6	2.8	-0.3	-2.1	-2.2	-2.8	-0.8	-1.2	-0.5	-2.8	-2.9	-1.9	-1.4
Happiness	3.3	3.9	8.3	2.2	-1.9	-1.7	-2.8	-2.9	-1.7	-1.3	-2.0	-2.1	-2.5	-0.5	-0.5
Ovarian Cancer	3.2	4.2	9.5	-0.8	1.3	1.9	2.8	3.1	1.4	2.5	1.2	2.6	3.0	1.1	0.1
Heart disease (mother)	3.2	3.9	10.6	-0.9	3.0	1.1	2.9	2.1	2.4	0.7	3.3	1.6	1.7	-0.5	0.7
Tinnitus: Yes, now most or all of the time	3.1	3.6	9.5	-2.7	-0.3	1.4	1.9	2.7	0.6	3.1	-0.2	1.9	2.6	1.8	0.6
Medication for hormone replacement therapy	2.9	3.3	9.1	0.8	0.4	-1.8	-1.5	-2.5	-0.2	-1.9	0.3	-3.0	-2.9	-2.4	-0.3
Illnesses of siblings	2.8	3.9	8.3	2.8	0.0	-2.5	-1.7	-2.7	0.4	-1.2	-0.2	-2.2	-2.9	-1.9	-2.0
Medication: Amlodipine	2.8	4.0	9.9	-1.8	1.4	2.3	2.6	2.5	0.5	3.1	1.4	2.5	2.5	0.0	-0.2
Friendships satisfaction	2.7	3.4	7.7	2.5	-1.4	-1.9	-1.9	-2.1	-0.9	-1.5	-1.5	-2.8	-2.3	-1.2	-0.9
Wheeze or whistling in the chest in last year	2.6	4.7	11.5	-0.7	2.7	0.9	3.4	2.9	2.5	2.0	2.6	1.8	2.3	-1.2	-0.8
Mouth/teeth dental problems: Loose teeth	2.6	3.0	12.3	3.5	-2.0	-0.3	-2.3	-1.6	-2.2	-0.3	-1.9	-1.3	-1.2	0.4	0.7
Ever highly irritable/argumentative for 2 days	2.5	3.0	6.7	2.5	0.1	-1.9	-1.2	-1.9	-1.0	-0.8	0.0	-1.9	-2.0	-2.4	-2.6
Hypothyroidism (self reported)	2.4	5.6	18.1	-0.7	-4.3	-0.5	-2.9	-1.3	-4.0	0.4	-4.2	-0.2	-0.4	2.3	-0.2
Pulse wave Arterial Stiffness index	2.3	2.7	6.6	-0.4	2.4	1.2	2.4	1.8	2.1	-0.9	2.6	0.9	1.2	0.0	1.4
Breast cancer (self-reported)	2.3	2.8	9.1	0.8	-3.0	-0.1	-1.9	-0.9	-2.2	0.5	-3.0	-0.2	-0.3	2.0	0.7
Pulse wave peak to peak time	2.2	2.6	6.8	0.1	-2.5	-0.9	-2.3	-1.6	-2.1	1.3	-2.6	-0.6	-1.1	0.1	-1.4
Mean Putamen Volume	2.1	2.4	5.8	0.3	-1.9	-0.3	-2.4	-2.1	-1.3	-1.6	-2.0	-1.6	-1.8	0.6	0.8
Alcohol drinker status: Never	2.1	2.5	7.5	-0.8	-1.6	2.1	-0.3	0.9	-2.0	0.6	-1.4	1.3	1.5	2.1	2.7
Irritable Bowel Disease (IBD)	2.0	4.7	8.3	-1.3	0.8	2.9	2.2	2.7	2.4	0.2	0.9	2.5	2.7	2.6	2.6
Coronary Artery Disease (CAD)	2.0	2.4	8.6	-1.1	2.3	0.5	1.4	1.0	0.6	0.5	2.9	1.6	1.0	-2.2	-1.5
Hip circumference	1.9	8.3	18.7	-1.3	-2.6	4.3	0.1	1.8	-3.0	3.6	-2.4	3.6	2.9	4.0	2.2
Vascular/heart problems diagnosed by doctor	1.9	5.1	13.5	1.5	-1.0	-3.2	-2.3	-2.8	0.2	-3.7	-0.9	-3.1	-3.1	-0.6	-0.2
Crohns Disease (2017)	1.8	4.0	8.1	-1.1	1.3	1.8	2.6	2.8	2.8	0.4	1.3	2.2	2.6	1.8	1.7
Qualifications: CSEs or equivalent	1.8	2.4	8.1	-1.0	-2.5	-0.2	-1.6	-0.7	-2.9	1.8	-2.6	-0.2	-0.1	0.6	-0.0
Ever taken oral contraceptive pill	1.8	2.0	4.1	1.0	-0.4	-2.0	-1.5	-1.9	-0.6	-1.5	-0.5	-1.9	-1.9	-1.0	-1.4
Basal cell carcinoma (self-reported)	1.8	2.1	6.0	2.5	-1.3	-1.3	-1.9	-1.6	-1.4	-0.6	-1.2	-1.1	-1.4	-0.5	-1.5
Wears glasses or contact lenses	1.7	2.0	5.3	-1.1	2.1	-0.2	2.1	1.3	1.6	0.8	2.3	1.3	1.0	-0.8	0.4
Ever smoked	1.7	3.0	6.3	2.2	-1.7	-2.0	-2.1	-1.9	-1.2	-0.7	-1.8	-2.5	-1.9	-0.7	-0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.9	-0.8	2.4	0.1	2.0	1.6	2.0	0.0	2.4	1.4	1.4	-0.4	0.1
Crohns Disease (2012)	1.6	2.6	7.2	-1.1	1.5	1.2	2.2	2.0	2.7	0.4	1.7	1.8	1.7	0.9	0.6
Systolic blood pressure, automated reading	1.6	4.6	8.4	-1.7	2.7	2.8	2.9	2.4	2.2	1.8	2.6	1.9	2.0	-0.8	-0.4
Knee pain experienced in last month	1.6	2.4	5.6	-1.3	-0.1	2.1	1.2	1.7	-0.4	2.4	-0.2	2.3	2.2	1.4	0.8
Medication: Bendroflumethiazide	1.6	2.4	7.1	-0.5	0.5	2.7	1.4	2.0	0.0	1.5	0.6	2.0	2.2	1.5	1.2
High blood pressure	1.5	4.1	12.6	-0.6	0.5	3.3	1.8	2.4	-0.5	3.5	0.4	2.8	2.7	0.9	0.2
Heart attack	1.5	1.9	5.2	-0.9	2.2	0.1	1.9	1.5	1.6	0.0	2.3	1.4	1.3	-0.6	0.3
Weight	1.5	7.4	19.4	-1.1	-1.5	4.4	0.9	2.2	-2.2	3.9	-1.5	3.7	3.2	3.3	1.9
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	8.0	0.7	-2.6	-0.4	-2.0	-1.2	-2.8	0.3	-2.5	-0.2	-0.6	1.2	0.3
Severe depression (siblings)	1.4	1.6	4.5	1.6	-1.7	-1.5	-1.2	-0.7	-2.1	1.1	-1.8	-0.7	-0.5	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	8.5	-1.4	-2.9	-0.1	-1.9	-0.7	-2.7	0.1	-2.9	-0.2	-0.2	1.7	-0.4
High blood pressure (siblings)	1.4	2.1	4.5	-1.5	1.1	2.1	1.6	1.6	0.4	-1.2	1.2	1.2	1.6	1.0	1.9
Hypertension (Self-reported)	1.4	3.9	11.1	-0.3	0.9	3.3	1.9	2.3	-0.3	3.2	0.8	2.7	2.6	0.6	0.5
Qualifications: None of the above	1.3	2.7	5.8	0.7	2.2	2.1	2.4	2.0	1.5	1.4	2.2	1.2	1.5	-0.4	0.3
Number of live births	1.3	1.9	3.7	0.4	-1.6	-0.8	-1.9	-1.7	-1.3	-1.2	-1.7	-1.1	-1.3	0.9	1.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	6.6	-2.6	-0.9	0.8	0.3	1.0	-1.1	1.7	-0.7	1.5	1.3	1.3	1.1
Medication: Omeprazole	1.3	1.5	4.5	1.1	-1.5	1.2	-0.8	-0.1	-1.9	-0.6	-1.3	-0.2	0.3	1.5	2.1
Medication: Seretide 50 evohaler	1.3	1.5	3.5	0.1	1.9	1.2	1.8	1.3	1.1	0.6	1.8	1.3	1.1	0.1	0.8
Cholesterol lowering medication	1.3	2.0	3.8	-1.9	0.9	1.4	1.9	1.9	1.2	1.4	1.0	1.3	1.9	-0.1	-0.3
HbA1C	1.2	1.3	3.5	-0.7	-1.7	0.8	-0.5	0.3	-1.4	0.2	-1.8	0.2	0.4	1.9	1.5
BMI	1.2	6.7	17.4	0.9	-3.6	3.1	-1.6	0.2	-3.5	1.9	-3.6	1.7	1.4	4.2	1.8
Average weekly spirits intake	1.2	1.5	4.7	-0.3	1.6	0.8	1.6	1.2	2.2	0.1	1.7	0.9	0.9	0.1	-0.8
Trunk fat mass	1.2	5.0	14.0	-1.0	-1.4	3.7	0.4	1.5	-2.2	2.8	-1.3	2.9	2.4	2.9	2.0
Depression (self-reported)	1.2	1.4	3.4	1.1	-0.8	-1.0	-1.3	-1.6	-0.6	-1.3	-0.9	-1.8	-1.6	-0.5	-0.8
Illnesses of mother	1.2	1.5	3.4	1.2	-1.8	-0.8	-1.9	-1.3	-0.8	-0.7	-1.8	-1.2	-1.2	0.0	-0.9
Gout (self-reported)	1.2	1.6	5.4	-1.2	-0.3	1.6	0.9	1.5	-0.1	2.3	-0.4	1.7	1.7	0.9	-0.4
Medication: Ibuprofen	1.2	1.4	2.9	0.5	-0.9	-1.3	-1.7	-1.7	-0.6	-0.9	-0.8	-1.6	-1.7	-0.9	0.2
Arm predicted mass (right)	1.2	6.0	13.5	-1.0	-1.0	3.6	1.4	2.6	-1.3	3.7	-1.0	3.5	3.2	2.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.8	1.0	-0.1	-1.0	-0.8	-1.2	-0.0	-2.2	0.1	-1.4	-1.2	0.2	1.6
Basal metabolic rate	1.2	6.4	17.1	-0.8	-1.2	4.1	1.2	2.3	-1.7	3.7	-1.2	3.6	3.2	2.8	1.4
Number of operations (self-reported)	1.2	1.8	4.3	0.1	-2.1	-0.0	-1.8	-1.2	-1.3	-1.3	-2.0	-1.4	-0.9	1.3	0.5
Irritability	1.2	2.0	6.0	-0.2	1.8	1.4	2.5	1.7	1.9	1.0	1.7	0.9	1.4	0.2	-0.0
Pain experienced in last month	1.2	2.0	5.9	0.5	2.1	-0.6	0.8	-0.4	2.4	-1.8	2.2	-0.7	-0.9	-1.2	1.0
Ulcerative Colitis (UC)	1.1	2.1	5.5	-1.2	0.2	2.3	1.1	1.5	1.5	-0.2	0.3	1.6	1.7	1.9	1.9
Blood Red Count	1.1	10.8	29.1	-0.9	-3.1	4.1	0.5	2.5	-2.8	3.2	-3.0	4.0	3.6	5.4	3.2
Systolic Blood Pressure	1.1	5.5	10.2	-2.0	2.8	3.2	3.2	2.7	2.6	1.9	2.5	2.2	2.3	-0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.6	1.9	-0.2	-1.0	-1.2	-1.5	-0.4	-1.8	-0.0	-1.6	-1.4	-1.0	-0.6
Medication: Atenolol	1.1	1.4	2.4	-0.9	1.0	1.3	1.6	1.5	1.1	1.3	1.1	1.4	1.5	0.4	-0.3
Medication: Levothyroxine sodium	1.1	1.9	5.8	-1.0	-2.3	-0.6	-1.8	-1.3	-1.6	-0.4	-2.4	-0.8	-0.9	1.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	5.2	1.1	-0.5	-1.8	-1.4	-1.5	-0.4	-2.3	-0.3	-1.5	-1.4	-0.6	-0.8
Pulse rate	1.1	1.9	4.9	-0.2	2.1	0.5	1.8	1.4	1.7	-0.2	2.2	0.6	1.0	-0.5	1.8
Arm fat-free mass (right)	1.1	5.8	13.4	-0.9	-1.1	3.7	1.3	2.4	-1.3	3.5	-1.0	3.4	3.1	2.9	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.9	2.0	-1.2	-1.0	-1.3	-1.2	-0.6	-1.6	-1.2	-1.1	-1.1	0.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.9	-0.7	-0.1	0.6	1.2	1.5	0.1	2.0	-0.2	1.7	1.7	0.7	-0.2
Emphysema/chronic bronchitis	1.1	1.2	3.9	2.0	1.1	-0.5	-0.4	-1.2	0.2	-0.7	1.2	-1.0	-1.4	-1.5	-0.6
Whole body fat mass	1.1	4.4	13.0	-0.9	-1.1	3.6	0.6	1.5	-2.0	2.7	-1.1	2.8	2.3	2.7	1.7
Leg fat mass (right)	1.1	4.3	13.8	-0.7	-1.0	3.7	0.8	1.6	-1.8	2.8	-1.0	2.6	2.3	2.5	1.4
Arm fat-free mass (left)	1.1	5.4	14.2	-0.6	-1.2	3.8	1.2	2.3	-1.4	3.5	-1.1	3.1	3.0	2.6	1.3
Unable to work because of sickness or disability	1.1	1.4	5.5	2.3	-0.6	-1.2	-1.1	-1.2	-0.9	-0.8	-0.6	-1.5	-1.1	-0.8	-0.6
Arm predicted mass (left)	1.1	5.6	14.4	-0.5	-1.4	3.8	0.9	2.1	-1.7	3.6	-1.4	3.1	2.9	2.7	1.2
Rheumatoid Arthritis	1.0	1.4	2.9	-0.4	-0.6	1.1	0.6	1.4	-1.0	1.7	-0.4	1.5	1.6	1.4	1.3
Height	1.0	18.9	43.2	-4.3	2.4	3.2	5.3	5.7	2.5	6.6	2.6	6.3	5.8	1.4	-0.4
Waist circumference	1.0	3.7	11.7	-0.4	-1.0	3.4	0.3	1.1	-2.0	2.1	-0.9	2.5	1.9	2.5	2.1
Hearing difficulty/problems with background noise	1.0	1.6	3.7	-1.3	0.3	0.4	1.4	1.9	0.2	0.2	0.7	1.7	1.9	1.7	1.4
Trunk fat-free mass	1.0	5.5	12.8	-0.8	-0.7	3.6	1.6	2.6	-0.6	3.3	-0.6	3.4	3.2	2.6	1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	6.6	-0.1	-1.8	-0.7	-1.6	-1.2	-2.6	0.4	-1.8	0.0	-0.6	0.3	0.2
Migraine (self-reported)	1.0	1.3	4.2	0.7	-2.1	0.2	-1.5	-0.7	-1.2	0.3	-1.9	-0.9	-0.6	0.9	0.8
Family relationship satisfaction	1.0	1.2	2.7	1.6	-1.3	-0.5	-1.2	-1.3	-0.6	-1.0	-1.5	-1.1	-1.1	0.5	-0.6
Whole body fat-free mass	1.0	5.5	14.7	-0.7	-1.0	3.8	1.3	2.3	-1.3	3.5	-1.0	3.4	3.0	2.6	1.1
Whole body water mass	1.0	5.5	14.6	-0.7	-1.1	3.8	1.2	2.2	-1.4	3.5	-1.1	3.4	3.0	2.6	1.1
Arm fat mass (left)	1.0	4.1	13.2	-0.5	-1.4	3.6	0.2	1.2	-2.3	2.3	-1.4	2.5	2.0	2.7	1.7
Financial situation satisfaction	1.0	1.3	3.0	1.7	-0.1	-1.3	-0.9	-1.2	-1.0	-0.5	-0.4	-1.2	-1.2	-1.1	-1.6
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.8	-1.7	1.5	-0.6	1.0	0.3	0.6	1.1	1.6	0.2	0.1	-1.4	-1.6
Ever depressed for a whole week	1.0	1.2	4.4	0.5	0.6	-2.0	-0.1	-0.5	-0.0	-0.1	0.5	-0.5	-0.5	-1.9	-2.1
Leg fat mass (left)	1.0	3.9	12.6	-0.5	-1.0	3.5	0.6	1.5	-1.9	2.8	-1.1	2.5	2.2	2.4	1.4
Schizophrenia (2018)	0.9	1.9	6.3	2.5	-0.1	-0.1	-1.3	-1.7	0.4	-1.8	0.0	-2.0	-1.7	-1.1	0.1
Schizophrenia vs Biploar Disorder	0.9	1.1	5.3	2.2	0.5	-0.7	-0.2	-0.3	0.3	0.4	0.8	-1.1	-0.5	-2.3	-0.6
Primary Biliary Cirrhosis	0.9	1.3	5.4	-2.3	0.2	0.7	1.0	1.3	-0.4	0.9	0.0	1.8	1.6	0.6	0.2
Blood White Count	0.9	6.3	13.9	1.9	3.0	-2.6	0.5	-1.5	3.1	-2.1	3.2	-2.4	-2.4	-3.7	-2.0
Hearing difficulty/problems: Yes	0.9	1.3	3.9	-0.6	0.3	0.8	1.2	1.8	0.2	0.8	0.8	2.0	1.8	1.2	0.9
Ever had hysterectomy (womb removed)	0.9	1.0	3.5	-1.3	-0.2	1.2	0.5	0.8	0.1	-0.6	-0.1	0.7	0.9	1.9	1.7
Diabetes (mother)	0.9	1.1	3.3	0.6	1.8	0.7	1.1	0.1	1.4	-1.0	1.6	-0.3	-0.2	-0.6	1.4
Leg fat-free mass (left)	0.9	4.8	14.7	-0.4	-1.4	3.8	0.5	1.5	-2.1	3.0	-1.5	3.0	2.4	2.5	1.2
Hand grip strength (right)	0.9	2.3	5.5	-0.8	1.5	1.0	2.3	2.3	1.6	1.8	1.4	1.6	1.8	0.1	0.0
Townsend deprivation index at recruitment	0.9	1.3	2.8	-0.2	1.3	-0.1	1.3	1.3	0.9	1.1	1.6	1.2	1.3	-0.7	-1.7
Leg predicted mass (left)	0.9	4.6	14.4	-0.5	-1.4	3.8	0.5	1.5	-2.0	3.0	-1.4	2.9	2.4	2.4	1.1
Had menopause	0.9	1.1	2.8	-1.2	1.5	0.5	1.3	0.9	0.3	0.2	1.7	0.3	0.7	-0.6	1.6
Medication: Ramipril	0.9	1.1	3.8	-0.2	-0.5	1.4	0.3	0.8	-1.2	1.2	-0.7	0.9	1.1	1.1	2.0
Arm fat mass (right)	0.9	3.9	13.1	-0.4	-1.3	3.6	0.3	1.2	-2.1	2.4	-1.3	2.4	2.0	2.5	1.4
Trunk predicted mass	0.9	5.0	12.0	-0.7	-0.8	3.5	1.4	2.4	-0.7	3.2	-0.8	3.2	3.0	2.5	1.1
Standing height	0.9	8.5	26.7	-2.6	-1.5	3.1	1.5	3.0	-1.0	5.2	-1.4	4.3	3.7	3.0	1.4
Breastfed as a baby	0.9	1.2	3.7	0.3	-1.3	-1.0	-1.9	-1.3	-1.9	0.4	-1.0	-0.5	-0.9	-0.1	0.6
Medication: Paracetamol	0.9	1.6	5.1	-0.5	2.3	-0.5	1.5	0.7	1.7	-1.0	2.2	0.1	0.3	-1.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.0	-0.1	-0.3	1.1	1.1	1.7	0.5	1.6	-0.2	1.2	1.7	0.4	0.3
Leg fat-free mass (right)	0.9	4.6	13.2	-0.1	-1.5	3.6	0.3	1.3	-2.3	3.0	-1.6	2.9	2.2	2.4	1.3
Osteoarthritis (self-reported)	0.9	1.1	2.9	-0.8	-1.4	1.2	-0.6	0.2	-1.7	0.9	-1.3	0.0	0.4	1.2	1.4
Smoking status: Current	0.9	1.4	9.9	3.1	-0.1	-0.5	-1.0	-1.1	0.2	-1.5	-0.2	-0.8	-1.0	-0.2	0.0
Number of self-reported non-cancer illnesses	0.9	1.6	3.9	-0.9	1.8	0.7	2.0	1.6	1.2	0.8	1.9	0.9	1.3	-0.6	-0.5
Average weekly champagne plus white wine intake	0.9	1.2	5.1	-0.3	1.7	-0.6	0.7	-0.1	0.8	-0.3	1.9	-0.2	-0.3	-2.3	-1.0
Diastolic blood pressure, automated reading	0.9	2.9	8.0	-0.6	1.1	2.8	2.1	2.3	0.8	2.1	0.9	2.1	2.3	0.3	0.3
Alzheimer’s Disease (including proxy)	0.8	1.1	2.9	1.4	-1.7	-0.7	-1.3	-0.7	-1.2	0.1	-1.7	-0.8	-0.7	0.7	0.4
HDL Cholesterol	0.8	1.3	3.3	-1.0	1.8	-0.2	1.1	0.7	1.5	-0.2	1.8	-0.6	0.1	-1.6	-1.1
Triglycerides	0.8	1.4	3.7	0.0	-0.7	1.7	0.7	1.3	-0.4	0.8	-0.6	1.4	1.6	1.9	1.2
Ulcerative Colitis	0.8	1.2	3.8	-0.9	0.1	1.7	0.6	0.7	1.0	-0.5	0.2	1.3	1.0	1.9	1.5
Hand grip strength (left)	0.8	2.0	4.9	-0.8	1.2	0.8	2.1	2.2	1.4	1.4	1.2	1.7	1.9	0.4	0.1
Trunk fat percentage	0.8	3.1	8.7	-0.9	-1.3	2.9	-0.1	0.8	-2.3	2.0	-1.3	2.0	1.6	2.3	1.8
Current tobacco smoking	0.8	1.2	8.3	2.9	0.0	-0.2	-1.0	-1.2	0.1	-1.4	-0.1	-0.8	-1.2	-0.4	0.1
Supplements: Glucosamine	0.8	1.1	2.8	0.7	-1.2	-1.7	-1.2	-1.0	-1.1	0.6	-1.0	-1.2	-1.1	-0.1	-1.0
High blood pressure (mother)	0.8	1.2	3.3	-1.2	1.0	1.8	1.5	1.0	0.3	1.0	0.9	1.4	0.9	0.4	0.6
Alcohol usually taken with meals	0.8	1.4	3.5	0.5	-1.9	-1.1	-1.5	-1.2	-1.7	0.3	-1.8	-0.7	-0.9	0.2	-0.4
Medication: Simvastatin	0.8	1.1	2.1	-1.3	1.1	1.2	1.5	1.4	0.7	0.8	1.0	0.5	1.2	-0.9	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.4	0.8	-1.0	-0.8	-1.5	-1.4	-0.6	-0.7	-1.0	-1.1	-1.3	-0.4	0.6
Medication: Lansoprazole	0.8	0.9	2.0	0.9	1.4	-0.7	1.1	0.5	1.3	0.2	1.4	-0.4	-0.0	-1.4	-0.6
Length of working week for main job	0.8	0.9	2.3	0.3	-1.3	1.0	-0.5	0.0	-1.3	0.4	-1.4	0.6	0.4	1.5	0.8
Exposure to tobacco smoke at home	0.8	0.9	2.1	1.1	-0.8	-0.9	-1.4	-1.3	-0.7	-0.1	-1.0	-0.9	-1.2	-0.5	-0.9
Overall health rating	0.8	1.6	5.1	-0.1	0.2	2.3	1.2	1.4	-0.0	0.7	0.4	1.7	1.7	1.9	1.0
Chest pain or discomfort	0.8	1.2	3.2	0.2	1.6	-0.1	1.5	0.8	1.2	0.6	1.6	0.1	0.5	-1.8	-1.1
Age at last live birth	0.8	1.1	3.4	0.7	0.3	-1.9	-0.4	-1.0	0.2	-1.8	0.3	-1.3	-1.1	-1.4	-0.6
Leg pain on walking	0.8	1.0	2.7	1.4	-1.4	0.9	-0.8	0.1	-1.6	0.8	-1.4	0.5	0.5	0.8	0.1
Medication: Aspirin	0.8	1.1	3.6	-0.7	1.9	1.1	1.0	0.3	1.3	-1.0	1.9	-0.1	0.2	-0.9	0.4
Illnesses of siblings: Diabetes	0.8	1.0	4.4	-2.1	-0.7	0.9	0.0	0.5	-0.9	0.6	-0.7	0.7	0.7	1.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	8.7	-0.6	-1.2	0.5	0.1	1.0	-1.1	2.9	-1.3	1.5	1.3	0.7	-0.1
Loneliness, isolation	0.8	1.1	6.0	2.5	0.5	-0.3	-0.1	-0.6	0.8	-1.7	0.6	-1.0	-0.8	-0.5	0.6
Osteoporosis (self-reported)	0.8	1.0	5.3	0.0	0.4	-2.3	-0.2	-0.8	-0.3	0.1	0.5	-0.6	-1.0	-1.2	-1.7
Medication: Aspirin	0.8	1.1	2.5	-1.0	1.5	1.6	1.2	0.7	0.9	-0.6	1.5	0.4	0.7	-0.2	1.0
Leg predicted mass (right)	0.8	4.5	12.8	-0.1	-1.6	3.6	0.3	1.3	-2.3	3.0	-1.6	2.8	2.2	2.4	1.2
Guilty feelings	0.8	1.3	4.9	-0.3	-1.1	1.5	-0.4	-0.0	-1.0	-0.4	-1.0	0.8	0.5	2.2	1.9
Average weekly beer plus cider intake	0.8	1.2	5.5	1.2	0.9	-1.0	0.2	-0.2	0.2	0.6	0.8	-0.7	-0.5	-2.0	-2.3
Risk taking	0.8	1.1	3.4	1.0	-1.7	0.3	-1.0	-0.2	-0.4	-0.4	-1.6	-0.5	-0.0	1.8	1.4
Heart disease (siblings)	0.8	1.0	3.2	-0.3	-0.6	1.0	0.5	1.2	-0.2	0.8	-0.6	1.1	1.3	1.8	1.5
LDL Cholesterol	0.7	1.2	3.2	-1.8	-0.8	0.9	0.3	1.1	-0.6	0.7	-0.7	1.3	1.2	1.6	0.9
Cardiovascular Disease	0.7	2.4	7.7	-0.8	0.5	2.2	1.4	1.8	-0.3	2.8	0.4	2.2	2.2	0.4	-0.7
Relative age of first facial hair	0.7	1.4	2.3	-1.5	-1.1	1.5	0.2	1.0	-1.2	1.4	-1.2	0.9	1.3	0.9	1.4
Medication: Co-codamol	0.7	0.8	2.4	-0.0	1.4	-0.4	0.6	0.1	1.3	-1.0	1.6	-0.1	-0.2	-0.1	-1.1
Stomach or abdominal pain in last month	0.7	0.8	2.5	1.6	-1.3	-0.9	-1.1	-0.5	-1.1	-0.3	-1.2	-0.5	-0.4	0.4	0.0
Sitting height	0.7	4.8	18.7	-1.6	-2.1	2.1	0.1	1.6	-2.2	4.3	-2.0	2.5	2.2	2.1	1.1
Body mass index (BMI)	0.7	2.8	11.1	0.1	-0.9	3.3	0.3	1.1	-1.8	1.7	-1.0	1.9	1.7	2.2	1.4
Number of incorrect matches in round	0.7	1.1	6.0	0.3	0.7	-0.6	-0.6	-1.2	0.4	-2.4	0.8	-1.3	-1.3	-0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	6.8	2.6	-1.1	0.3	-1.0	-0.7	-0.8	-0.7	-1.1	-0.4	-0.4	0.8	-0.2
Pulse wave reflection index	0.7	0.9	2.1	0.7	1.4	-0.7	0.8	0.3	1.2	-0.5	1.4	0.0	-0.0	-1.0	-1.4
Body fat percentage	0.7	2.7	8.3	-0.8	-0.9	2.9	0.2	1.0	-1.9	1.9	-0.9	2.0	1.6	2.1	1.7
Leg fat percentage (right)	0.7	2.4	9.1	-0.9	-0.2	3.0	1.0	1.5	-0.9	1.9	-0.2	1.9	1.9	1.6	1.2
Alcohol intake frequency.	0.7	1.5	8.0	0.5	-1.2	2.8	-0.8	-0.2	-1.4	0.4	-1.1	0.6	0.4	1.2	1.6
Supplements: Vitamin C	0.7	0.9	4.1	-0.0	0.6	-0.8	-0.0	-0.6	0.4	0.1	0.3	-1.0	-0.9	-2.0	-1.7
Average weekly red wine intake	0.7	1.1	6.1	-2.5	1.1	0.3	1.2	0.7	0.9	0.4	1.1	0.5	0.5	-0.8	-0.4
Long-standing illness, disability or infirmity	0.7	1.1	2.3	-1.0	0.8	1.1	1.5	1.4	0.2	1.4	1.1	1.1	1.2	-0.1	-0.2
Commuting to job workplace: Walk	0.7	0.7	2.2	-1.5	0.9	0.7	1.1	1.0	1.2	0.2	0.9	0.5	0.7	-0.3	0.3
Mineral and other dietary supplements	0.7	1.0	2.5	1.6	-1.0	0.2	-1.1	-0.8	-0.3	-1.5	-1.2	-0.6	-0.6	0.7	1.1
Medication: Paracetamol	0.7	1.1	3.5	-1.0	1.8	-1.1	0.9	0.4	1.1	-1.0	1.9	-0.3	-0.0	-1.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	0.8	-1.2	1.0	-0.4	0.3	-1.6	0.2	-1.0	0.2	0.6	1.1	1.3
Depression (Nagel 2018)	0.6	0.9	3.1	-0.4	0.3	0.9	1.0	1.2	0.9	-0.3	0.4	1.2	1.3	1.8	-0.0
Major Depression (MDD)	0.6	0.7	3.0	1.5	-0.2	-1.3	-0.2	-0.4	0.2	-0.2	-0.2	-0.5	-0.3	-0.7	-1.7
Age at First Birth	0.6	0.8	2.4	-1.4	-0.3	1.0	0.7	1.0	0.0	1.5	-0.3	0.8	1.0	0.4	1.1
Fasting Glucose	0.6	0.8	4.6	0.6	-0.2	0.9	0.5	0.6	-0.7	2.1	-0.2	1.0	0.7	0.1	-0.9
Schizophrenia (2014)	0.6	1.3	3.4	1.9	0.7	-0.1	-0.6	-1.3	0.7	-1.4	0.0	-1.5	-1.5	-1.5	0.5
Fed-up feelings	0.6	1.1	3.8	1.1	0.8	2.0	1.0	0.6	1.1	-0.4	0.8	0.7	0.6	1.1	1.6
Taking other prescription medications	0.6	0.9	2.5	0.8	1.5	-0.4	0.9	0.4	1.5	-0.3	1.6	-0.5	-0.1	-1.1	-0.6
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	1.3	-1.2	-0.8	-1.3	-0.6	-1.0	-0.3	-1.1	-0.7	-0.5	0.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	-1.1	0.6	0.3	1.2	1.4	0.5	0.7	0.5	1.0	1.3	-0.2	-0.1
Financial difficulties in last 2 years	0.6	0.8	4.0	2.0	0.2	-1.0	-0.7	-1.2	0.2	-0.8	0.0	-0.8	-1.1	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.6	0.9	4.6	-1.0	0.6	-0.5	-0.1	-0.7	0.1	-2.1	0.4	-1.1	-0.8	-0.9	0.8
Mouth/teeth dental problems: Dentures	0.6	1.1	2.8	1.3	1.3	-0.3	0.3	-0.1	1.1	-1.1	1.7	-1.0	-0.4	-1.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.2	1.8	0.9	-0.9	0.1	-0.7	0.8	-0.9	0.8	-0.6	-0.9	-1.1	-1.2
Hair/balding pattern: Pattern 4	0.6	1.5	7.2	-2.0	-0.2	0.2	0.7	1.2	-0.1	2.7	0.0	1.2	1.3	0.3	-1.4
Comparative body size at age 10	0.6	1.6	4.6	1.5	-1.3	0.7	-1.4	-1.3	-1.7	-1.1	-1.4	-0.6	-0.7	0.6	2.1
Shortness of breath walking on level ground	0.6	0.7	3.2	0.4	-1.4	0.0	-0.9	-0.6	-1.8	0.3	-1.3	-0.5	-0.3	0.2	0.3
Arm fat percentage (left)	0.6	2.5	7.4	-0.4	-1.4	2.7	-0.4	0.4	-2.4	1.5	-1.4	1.6	1.1	2.1	1.4
Back pain experienced in last month	0.6	0.8	2.0	0.4	-0.7	-0.2	-1.3	-1.2	-0.8	-1.4	-0.8	-1.0	-1.0	0.4	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	0.0	-1.1	-0.9	-1.3	-0.9	-1.3	-0.4	-1.0	-0.5	-0.5	-0.4	-0.4
Medication: Lisinopril	0.6	0.7	4.1	-0.9	0.0	2.0	0.0	0.5	-0.3	1.1	-0.1	0.9	0.8	0.3	0.9
Illnesses of father: High blood pressure	0.6	0.8	5.7	-0.1	0.2	0.3	0.7	0.6	-0.4	1.1	0.1	0.8	0.5	-0.3	-2.4
Leg fat percentage (left)	0.6	2.3	8.2	-0.6	-0.4	2.9	0.8	1.4	-1.2	2.0	-0.3	1.9	1.8	1.7	1.3
Supplements: Calcium	0.6	0.6	1.1	0.4	1.1	-1.0	-0.1	-0.7	0.1	-0.6	1.1	-0.6	-0.9	-1.0	-0.9
Alzheimer’s Disease (in father)	0.5	0.6	1.4	0.3	-0.8	0.5	-0.8	-0.5	-1.2	0.7	-0.7	0.3	-0.1	1.0	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	4.6	1.3	0.2	0.5	-0.1	-0.2	0.6	-2.1	0.0	-0.1	0.2	0.6	0.5
Smoking Status	0.5	1.2	5.1	2.3	1.0	-0.8	-0.2	-0.9	1.0	-0.9	0.8	-1.1	-1.0	-1.6	-0.4
Number of treatments/medications taken	0.5	0.8	1.9	-1.1	1.3	0.2	1.1	0.8	0.6	0.7	1.4	-0.1	0.5	-1.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.8	1.1	-1.2	0.7	-0.3	0.1	0.0	0.2	-1.3	-0.3	0.1	0.8	-0.4
Multivitamins +/- minerals	0.5	0.6	1.7	0.3	-0.4	-1.1	-1.0	-1.3	-1.2	-0.7	-0.4	-0.6	-1.0	-0.3	-0.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.9	-0.1	-0.9	-0.4	-0.8	-0.6	-0.1	-0.2	-1.2	-0.9	-1.3	-0.9
Fluid intelligence score	0.5	1.0	2.8	-0.5	1.1	-1.6	0.2	-0.2	0.5	-0.7	1.1	-0.2	-0.4	-1.7	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.8	0.6	-2.1	0.5	-1.1	-0.2	-2.1	1.7	-2.2	0.5	0.2	1.3	0.8
Prospective memory result	0.5	0.7	1.8	-0.3	1.1	0.5	1.3	1.0	1.4	0.4	1.1	0.5	0.7	-0.2	-0.1
Lung cancer (father)	0.5	0.6	2.2	-0.4	-0.3	-0.2	0.2	0.6	-0.7	1.3	-0.2	1.5	0.8	0.8	-0.2
Age at first live birth	0.5	0.9	3.3	-0.9	0.8	-1.8	0.2	-0.4	0.7	-1.1	0.9	-0.8	-0.8	-1.1	-0.7
Medication: Blood pressure	0.5	0.8	4.7	-0.3	0.4	1.2	0.9	0.8	-0.2	2.2	-0.0	0.9	0.8	-0.2	-0.6
Medication: Allopurinol	0.5	0.7	1.7	0.0	-1.1	0.9	0.1	0.6	-0.5	0.8	-1.3	0.6	0.9	1.2	1.1
Pulse rate, automated reading	0.5	1.6	3.9	2.0	1.8	-0.6	0.8	0.2	1.8	-1.7	1.8	-0.6	-0.2	-0.9	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.9	1.1	0.4	1.1	0.4	0.1	-0.2	-0.4	0.4	0.4	0.1	0.5	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	0.8	-0.0	0.9	0.9	1.3	-0.2	1.1	0.0	0.8	1.2	0.2	0.4
Illnesses of father: Heart disease	0.5	0.7	4.4	0.8	0.5	-0.2	-0.3	-0.5	0.1	-2.1	0.5	-1.0	-0.5	-0.3	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.1	0.6	-0.4	0.7	-0.3	0.1	-0.0	-1.3	-0.3	0.4	0.4	1.0	1.8
Ever had bowel cancer screening	0.5	0.6	2.6	-1.4	0.3	0.2	0.9	0.8	0.0	1.6	0.3	0.3	0.6	-0.8	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	2.1	0.4	0.5	0.0	-0.1	-0.2	0.9	-1.4	0.5	-0.9	-0.5	-0.4	1.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.2	0.7	-1.0	0.7	-0.9	-0.6	-0.7	-0.6	-0.9	0.3	-0.2	1.5	0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	3.4	1.4	0.4	-0.1	-0.7	-1.3	1.0	-1.8	0.3	-1.2	-1.3	-0.5	-0.2
Neuroticism (Nagel 2018)	0.4	0.9	2.8	0.4	0.6	1.3	1.1	0.7	1.7	-0.1	0.7	0.8	0.9	1.4	0.4
Prostate Cancer	0.4	0.5	2.1	0.5	1.2	0.2	0.2	-0.5	0.1	-0.6	1.0	-0.4	-0.7	-1.4	-0.6
Neuroticism (2016)	0.4	0.6	2.8	0.9	0.9	0.5	1.1	0.8	1.7	-0.4	0.0	0.5	0.7	0.2	-0.0
Blood Platelet Count	0.4	5.1	11.9	1.2	2.0	-3.5	-0.2	-1.4	2.4	-2.1	2.0	-3.0	-2.4	-3.1	-1.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.6	1.1	-1.0	0.3	-1.1	-0.7	-1.6	0.6	-1.1	-0.6	-0.4	-0.2	-0.4
Lung FEV1/FVC ratio	0.4	2.3	7.6	1.0	-2.8	0.8	-1.6	-0.5	-1.8	0.5	-2.3	0.2	-0.2	2.5	-0.1
Lung FVC	0.4	2.2	4.4	1.2	-1.9	-1.4	-2.1	-1.5	-2.0	0.2	-2.1	-1.1	-1.3	0.5	0.8
Sensitivity / hurt feelings	0.4	0.6	2.8	0.9	0.4	-0.7	0.6	0.3	1.5	-0.5	0.5	-0.2	0.2	-0.3	-1.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	0.3	0.9	0.0	0.9	0.6	1.2	-0.7	1.2	0.5	0.5	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.7	0.6	-0.4	-1.0	-0.7	-0.8	-0.7	-0.8	-0.3	-1.3	-0.8	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.3	-0.3	-0.3	1.2	-0.2	-0.3	-1.5	0.8	-0.3	0.3	0.0	-0.5	-0.6
Average weekly fortified wine intake	0.4	0.5	1.7	-1.3	0.6	1.0	0.2	-0.0	0.2	-1.0	0.8	0.9	0.3	0.1	0.8
Relative age voice broke	0.4	0.6	1.8	-0.7	0.8	0.3	1.1	1.2	0.8	0.2	0.8	0.1	0.7	-0.4	1.3
Serious illness, injury or assault to yourself	0.4	0.5	2.1	-0.2	-0.6	1.4	0.2	0.4	-0.4	0.5	-0.7	0.5	0.7	0.8	0.6
Past tobacco smoking	0.4	0.8	1.8	-1.1	1.0	1.2	0.9	0.7	0.7	-0.0	1.2	1.3	0.6	0.5	0.1
Arm fat percentage (right)	0.4	1.7	6.2	-0.0	-1.2	2.5	-0.4	0.1	-2.0	1.2	-1.2	1.2	0.8	1.6	1.0
Time employed in main current job	0.4	0.4	2.6	-1.6	0.2	-0.3	0.2	0.2	0.3	0.8	0.2	0.1	0.1	-0.7	-1.1
Worrier / anxious feelings	0.4	0.8	2.1	0.1	0.2	0.3	1.2	1.4	1.1	0.8	0.3	1.3	1.4	0.7	0.1
Noisy workplace	0.4	0.5	3.8	2.0	-0.7	0.2	-0.8	-0.5	-0.4	-0.2	-0.7	-0.5	-0.3	-0.3	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.3	0.7	-0.8	0.6	-0.9	-0.7	-0.6	-0.5	-0.7	0.2	-0.4	1.1	0.6
Health satisfaction	0.4	0.5	1.5	0.9	-0.7	0.1	-0.7	-0.7	-1.2	-0.8	-0.7	-0.9	-0.6	-0.3	0.1
Qualifications: College or University degree	0.4	1.1	3.8	0.2	1.7	-1.2	1.0	0.3	2.0	-0.4	1.9	0.4	-0.1	-0.5	-0.2
Neck or shoulder pain in last month	0.4	0.5	2.2	-0.4	-0.8	0.8	-0.0	0.4	-1.5	0.6	-0.9	0.0	0.6	0.3	1.1
Comparative height size at age 10	0.4	2.4	5.7	-1.6	0.3	1.2	1.6	2.1	0.9	2.1	0.5	2.4	2.2	1.3	0.4
Had major operations	0.4	0.4	0.9	0.6	0.8	0.7	0.8	0.7	1.0	-0.5	0.8	-0.2	0.4	-0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.5	-1.6	-0.3	-1.1	-0.7	-0.6	-0.0	-0.8	-0.2	0.1	-0.4	0.8	0.2
Mood swings	0.4	0.8	1.9	0.3	1.3	1.2	1.1	0.6	1.2	-0.3	1.4	0.1	0.3	-0.4	0.5
Medication: Gliclazide	0.4	0.4	1.4	0.5	0.6	0.1	0.7	0.7	0.3	0.5	0.7	1.2	0.8	0.6	0.2
Hearing aid user	0.4	0.5	1.9	-0.1	0.9	-0.3	0.6	0.1	1.4	-0.7	0.9	-0.4	-0.1	-0.7	-0.8
High cholesterol (Self-reported)	0.4	0.7	2.0	0.6	1.3	-0.1	0.5	-0.1	1.0	-0.9	1.2	-0.7	-0.2	-1.4	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.1	-0.1	-0.9	-0.4	-0.7	0.2	-0.6	-0.2	-1.0	-0.8	-0.9	-1.0
Myopia	0.4	0.5	2.2	0.5	1.1	1.5	0.9	0.3	0.7	0.0	0.8	0.5	0.3	-0.6	-0.2
Bipolar Disorder (2018)	0.3	0.5	1.5	-0.9	0.8	0.2	0.5	0.1	1.2	-1.1	0.8	0.6	0.1	0.5	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.0	-0.6	1.0	-0.9	0.3	0.1	1.3	-0.6	1.1	0.1	0.0	-1.4	-1.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	0.4	-1.0	-0.3	-0.0	0.6	-0.6	0.8	-1.1	-0.1	0.4	0.6	-0.0
Lupus	0.3	0.4	1.2	0.5	-1.0	0.1	-0.9	-0.8	-0.6	0.2	-1.1	-0.4	-0.7	0.4	0.2
Waist Hip Ratio (WHR)	0.3	1.2	4.1	1.2	2.0	-0.4	1.0	-0.1	0.9	-0.8	1.9	-0.2	-0.3	-1.1	0.9
Chronotype (morning person)	0.3	0.6	1.3	-1.0	-0.5	-0.2	0.1	0.5	-0.8	1.1	-0.5	1.1	0.8	-0.4	-1.1
Tanning	0.3	3.3	6.9	1.5	2.6	-0.4	0.3	-1.1	2.5	-2.3	2.5	-1.6	-1.6	-2.2	-0.9
Angina	0.3	0.4	1.4	0.2	0.4	0.9	0.7	0.6	0.4	-0.8	0.4	0.3	0.6	0.8	1.2
Supplements: Zinc	0.3	0.3	0.8	-0.2	-0.4	0.9	0.3	0.6	-0.3	0.5	-0.4	0.9	0.7	0.5	0.4
Diabetes (father)	0.3	0.4	1.5	-1.2	-0.6	-0.4	-0.4	-0.3	-0.4	0.0	-0.6	0.2	-0.2	1.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.2	0.8	0.5	0.9	0.9	0.6	-0.3	0.9	0.7	0.8	0.1	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	0.1	-0.9	-0.2	-0.4	-0.1	-0.6	1.1	-0.9	0.0	-0.0	-0.1	-0.6
Nervous feelings	0.3	0.5	2.0	0.7	0.6	-1.4	0.3	-0.3	1.3	-0.7	0.7	-0.7	-0.5	0.0	-0.0
Mouth/teeth dental problems	0.3	0.5	1.9	-0.6	1.0	0.4	0.9	0.2	1.4	-0.3	0.6	0.3	0.0	-0.4	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	4.5	2.1	0.5	0.6	0.1	0.0	0.2	-0.3	0.5	-0.2	0.0	-0.0	0.4
Falls in the last year	0.3	0.3	1.3	0.3	-0.5	0.0	-0.1	0.2	-0.8	1.1	-0.4	0.3	0.3	-0.4	-1.1
Tense / ‘highly strung’	0.3	0.5	1.6	1.3	-1.0	-0.9	-0.5	-0.3	-0.5	-0.2	-0.7	-0.7	-0.1	0.0	-1.0
Peak expiratory flow (PEF)	0.3	0.7	2.2	1.2	-0.9	1.5	0.0	0.4	-0.1	1.1	-0.8	0.7	0.5	1.1	0.6
Headache pain in last month	0.3	0.5	1.7	0.1	-1.1	-0.1	-0.8	-0.6	-1.3	-0.1	-1.3	-0.8	-0.4	-0.0	0.0
Number of full brothers	0.3	0.4	1.7	1.3	0.6	0.1	-0.2	-0.4	-0.2	-0.3	0.7	-0.3	-0.3	-1.1	-0.1
Number of children fathered	0.3	0.3	1.2	-0.9	0.1	-0.2	0.1	-0.0	1.0	-0.8	0.1	0.3	0.1	1.1	0.4
Angina (self-reported)	0.3	0.4	1.6	0.1	0.5	0.9	0.6	0.5	0.3	-0.8	0.4	0.2	0.5	0.6	1.3
Number of full sisters	0.3	0.3	1.1	0.5	0.9	0.0	-0.1	-0.5	-0.1	-1.0	1.1	-0.1	-0.4	-0.6	-0.2
Medication for cholesterol	0.3	0.4	1.1	1.0	-0.9	-0.8	-0.7	-0.5	-0.5	0.2	-1.0	-0.2	-0.4	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.4	0.1	0.3	1.5	0.9	1.0	-0.2	1.1	0.4	0.9	0.9	0.3	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	1.1	-0.8	-0.6	-0.3	-0.2	-0.2	0.2	-0.9	-0.5	-0.3	0.5	-1.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	0.4	0.5	1.3	0.5	0.1	1.2	-0.7	0.6	0.2	0.2	0.8	0.7
Bipolar Disorder (2011)	0.2	0.2	0.8	-0.5	0.3	0.1	0.2	0.2	0.9	-0.0	0.3	0.6	0.4	-0.1	-0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.6	-0.6	-0.7	-0.6	-0.5	-0.9	-0.0	-0.8	0.1	-0.2	0.2	-0.7
Hair Pigment	0.2	7.1	16.0	-2.5	-2.3	2.9	0.6	2.6	-2.1	4.0	-2.1	3.4	3.2	3.3	0.5
Vitamin and mineral supplements	0.2	0.3	1.0	-0.8	-0.4	0.8	0.1	0.6	0.2	0.1	-0.4	0.2	0.5	1.0	0.3
Medication: Metformin	0.2	0.2	0.5	0.6	0.7	0.4	0.4	0.3	0.4	0.6	0.7	0.5	0.5	-0.6	-0.1
Pack years adult smoking proportion	0.2	0.3	1.6	-0.3	0.0	0.3	-0.4	-0.7	-0.7	0.7	-0.2	-0.3	-0.6	-1.3	-0.5
Impedance of leg (right)	0.2	1.2	3.6	-1.4	1.1	-1.9	0.7	0.3	1.8	-0.2	1.0	-0.8	-0.4	-1.2	-0.8
Maternal smoking around birth	0.2	0.2	1.9	1.4	-0.4	-0.4	-0.2	-0.0	-0.4	-0.4	-0.3	-0.2	0.1	0.1	0.5
Impedance of leg (left)	0.2	1.1	4.2	-1.0	1.1	-2.0	0.6	0.3	1.7	-0.1	1.1	-0.7	-0.4	-1.1	-0.6
Had other major operations	0.2	0.3	0.9	0.3	0.0	0.9	0.1	0.2	-0.0	-0.4	0.1	0.5	0.5	0.9	0.7
Forced vital capacity (FVC)	0.2	0.9	2.7	0.2	-1.1	0.6	-0.0	0.7	-0.9	1.6	-1.2	1.0	0.8	1.2	1.0
Pain all over the body in last month	0.2	0.2	1.0	0.2	0.5	-0.1	0.3	0.1	1.0	-0.2	0.6	-0.1	-0.0	-0.1	-0.5
Diabetes (self-reported)	0.2	0.3	1.1	0.9	-0.1	0.5	0.1	0.4	-0.3	1.1	-0.1	0.5	0.6	-0.0	-0.8
Neuroticism score	0.2	0.3	1.7	0.8	0.6	0.2	0.7	0.2	1.3	-0.6	0.7	-0.1	0.2	0.2	0.1
Impedance of arm (right)	0.2	0.8	1.8	-0.9	-0.2	-1.3	-1.0	-1.2	-0.0	-0.8	-0.1	-1.0	-1.3	-0.9	-0.4
Father’s age at death	0.2	0.3	1.4	-0.1	-0.6	-0.2	-0.4	-0.2	0.4	-0.5	-0.4	-0.1	-0.1	1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.5	-0.5	0.3	-0.2	0.0	0.1	0.2	-1.2	0.4	-0.0	0.0	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	3.0	0.3	-1.2	0.5	-0.4	0.2	-1.1	1.7	-1.2	0.7	0.4	0.8	0.5
Birth weight of first child	0.2	0.4	0.8	-0.6	0.8	-0.2	0.1	-0.6	0.7	-0.1	0.8	-0.8	-0.8	-0.9	-0.7
Loud music exposure frequency	0.2	0.2	0.8	0.9	0.4	0.1	-0.2	-0.4	0.0	-0.6	0.4	-0.1	-0.3	-0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	2.5	0.6	-0.2	-0.5	-0.4	-0.3	0.6	-1.6	0.1	-0.3	-0.3	0.5	0.9
Glaucoma (self-reported)	0.2	0.3	1.2	0.1	-0.6	0.1	-0.8	-0.5	-1.1	-0.2	-0.5	0.3	-0.1	-0.2	0.1
Birth weight	0.2	0.4	1.8	-0.7	0.9	-0.5	0.3	-0.3	0.5	0.4	0.9	-0.2	-0.4	-1.3	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.8	0.7	-0.4	0.1	-0.1	0.4	-0.6	0.6	-0.3	-0.2	-0.5	-0.7
Worry too long after embarrassment	0.2	0.3	1.2	1.1	-0.8	-0.2	-0.7	-0.6	-0.5	-0.5	-0.7	-0.2	-0.4	0.2	-0.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.4	-0.6	0.4	-0.4	-0.2	-0.5	-0.3	-0.7	-0.5	-0.2	0.3	0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	1.6	0.4	-0.6	-0.1	-0.1	-0.0	-0.7	1.3	-0.6	0.5	0.1	0.3	-0.9
Mean time to correctly identify matches	0.2	0.3	1.4	-0.6	0.7	-0.0	0.4	-0.1	0.6	-1.2	0.7	-0.1	-0.1	0.1	0.5
Suffer from ‘nerves’	0.2	0.3	1.6	-1.2	0.4	-0.3	0.7	0.4	0.6	0.6	0.4	-0.0	0.3	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.9	0.4	0.3	0.3	0.3	-0.0	0.3	0.3	-0.1	0.1	-0.2	0.9
Diabetes diagnosed by doctor	0.2	0.3	0.9	0.4	-0.1	0.9	-0.2	0.1	-0.6	0.9	-0.2	0.3	0.3	-0.1	-0.8
Qualifications: nursing, teaching	0.2	0.2	0.6	0.0	-0.5	0.1	-0.5	-0.5	-0.8	0.3	-0.7	-0.6	-0.5	-0.5	0.3
Eye problems/disorders: Cataract	0.2	0.3	0.7	0.6	0.6	-0.8	-0.1	-0.5	0.0	-0.5	0.7	-0.2	-0.6	-0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.3	1.1	0.1	-0.2	0.1	-0.1	-0.1	0.3	-0.1	-0.6	-0.3	-0.8	-0.2
Miserableness	0.2	0.4	1.7	-0.4	0.6	1.3	0.7	0.4	0.7	-0.1	0.8	0.2	0.4	0.2	0.3
Mother’s age at death	0.2	0.2	0.7	0.1	-0.2	0.0	-0.7	-0.9	-0.2	-0.4	-0.3	-0.7	-0.8	-0.2	0.0
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.6	-0.1	0.3	0.3	0.5	0.3	0.2	-0.1	0.9	0.7	0.8	0.2
Medication: Atorvastatin	0.2	0.3	0.6	0.5	0.6	0.5	0.6	0.4	0.4	0.3	0.8	0.7	0.5	-0.4	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	1.6	-0.4	0.1	0.2	0.1	0.1	0.7	-1.3	0.1	0.3	0.1	0.6	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.9	-0.4	0.4	-0.2	0.0	-0.6	0.5	-0.3	0.6	0.3	0.7	0.0
Worry (Nagel 2018)	0.1	0.3	1.7	-0.1	0.0	-0.4	0.6	0.4	1.3	0.5	0.1	0.2	0.5	0.4	-0.7
Reaction Time	0.1	0.3	1.2	-1.1	0.5	0.1	0.6	0.3	0.9	-0.7	0.4	-0.1	0.2	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.5	-0.1	0.0	-1.2	-0.2	-0.2	-0.1	0.1	0.1	0.2	-0.1	-0.8	-0.8
Heel T-Score	0.1	0.9	3.0	1.2	-0.8	-0.1	-1.1	-1.0	-1.7	-0.4	-1.2	-1.0	-0.9	-0.3	-0.7
Neuroticism	0.1	0.3	1.6	0.4	0.3	0.3	0.6	0.3	1.3	-0.2	0.5	0.2	0.4	0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	1.0	0.3	-0.2	1.0	-0.2	-0.2	0.2	-0.5	-0.1	-0.5	-0.2	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.7	0.8	0.6	0.0	0.1	-0.1	-0.3	-0.3	0.5	-0.3	-0.1	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.3	0.9	0.5	0.5	0.2	-0.2	-0.2	0.8	-0.0	0.1	-0.2	0.3
Impedance of arm (left)	0.1	0.7	1.5	-1.0	-0.7	-1.2	-1.1	-1.1	-0.7	-0.5	-0.6	-0.7	-1.0	-0.3	0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	2.2	0.0	-0.4	-0.0	0.2	0.6	-0.2	1.5	-0.6	0.6	0.6	0.4	0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.9	-0.2	-0.1	-0.0	0.1	0.1	0.2	-0.4	-0.2	0.1	0.4	-0.2	-1.0
Smoking status: Previous	0.1	0.2	0.9	-0.2	-0.4	-0.0	0.2	0.3	-0.5	0.9	-0.6	-0.1	0.4	-0.3	0.6
Age started oral contraceptive pill	0.1	0.1	0.6	-0.2	-0.6	-0.3	-0.3	0.1	0.2	-0.5	-0.3	-0.1	0.2	0.8	-0.3
Pack years of smoking	0.1	0.2	0.6	-0.4	-0.1	0.6	-0.3	-0.5	-0.6	0.8	-0.2	-0.1	-0.4	-0.8	-0.2
Impedance of whole body	0.1	0.7	3.4	-0.9	-0.1	-1.9	-0.6	-0.7	0.2	-0.5	0.0	-0.9	-1.0	-0.7	-0.1
Age when periods started (menarche)	0.0	0.1	0.5	0.7	0.1	0.3	0.3	0.1	0.4	0.5	0.0	0.0	-0.0	0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.4	-0.1	-0.5	-0.3	-0.2	-0.0	0.3	-0.1	0.2	-0.2	-0.2	0.5
Medication: Cholesterol lowering	0.0	0.0	0.2	0.2	0.1	0.5	0.2	0.1	-0.1	-0.3	-0.1	-0.2	0.2	0.1	0.2

Hub : Genes

TLR6

Models

Trait associations