TWAS hub - FAM114A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0330	1.0e-02	0.012	0.004	0.016	0.013	0.011	1.2e-02	8.3e-02	3.9e-03	8.5e-03	1.5e-02
2	GTEx	Adipose Subcutaneous	0.2110	0.0530	2.8e-08	0.166	NA	0.154	NA	0.169	1.6e-13	NA	1.4e-12	NA	9.5e-14
3	GTEx	Breast Mammary Tissue	0.1100	0.0480	7.4e-03	0.037	NA	0.017	NA	0.053	5.1e-03	NA	4.2e-02	NA	1.0e-03
4	GTEx	Breast Mammary Tissue (Female)	0.0747	0.0760	1.8e-01	-0.006	NA	-0.004	NA	0.008	5.1e-01	NA	4.6e-01	NA	1.7e-01
5	GTEx	Esophagus Mucosa	0.1420	0.0550	1.2e-03	0.026	NA	0.012	NA	0.027	7.1e-03	NA	5.0e-02	NA	6.6e-03
6	GTEx	Nerve Tibial	0.3210	0.0646	1.1e-10	0.245	NA	0.240	NA	0.257	2.4e-17	NA	5.4e-17	NA	2.8e-18
7	GTEx	Skin Not Sun Exposed Suprapubic	0.2320	0.0580	2.1e-06	0.168	NA	0.133	NA	0.128	1.7e-09	NA	1.0e-07	NA	1.7e-07
8	GTEx	Skin Sun Exposed Lower leg	0.2250	0.0480	2.1e-09	0.244	NA	0.230	NA	0.238	3.6e-20	NA	6.4e-19	NA	1.3e-19
9	GTEx	Spleen	0.6770	0.0860	6.6e-07	0.083	NA	0.160	NA	0.137	3.7e-03	NA	6.8e-05	NA	2.3e-04
10	GTEx	Testis	0.3730	0.0770	4.9e-07	0.196	NA	0.130	NA	0.203	4.5e-09	NA	2.2e-06	NA	2.2e-09
11	METSIM	Adipose	0.0820	0.0239	1.8e-06	0.071	0.036	0.064	0.051	0.068	9.3e-11	3.7e-06	6.2e-10	3.7e-08	2.1e-10
12	ROSMAP	Brain Pre-frontal Cortex	0.0919	0.0299	9.1e-06	0.048	0.036	0.045	0.041	0.052	7.4e-07	1.6e-05	1.7e-06	4.3e-06	2.8e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Allergy or Eczema	29.7	78.2	346.0	-3.7	-8.8	-13.9	-9.4	-12.8	-1.7	-3.2	-3.2	-2.8	-18.6	3.9	-3.1
Hayfever, allergic rhinitis or eczema	22.9	49.8	225.0	-3.1	-6.8	-11.0	-7.7	-10.4	-0.6	-2.3	-2.0	-2.2	-15.0	3.2	-2.1
Allergy	18.4	42.2	187.7	2.8	6.1	10.2	6.7	10.1	0.4	1.8	1.7	2.3	13.7	-2.8	1.7
Hayfever/allergic rhinitis (self-reported)	8.1	10.8	49.0	-0.4	-2.6	-4.7	-3.9	-5.1	0.7	-0.7	-0.1	-1.8	-7.0	2.2	0.3
Breast Cancer	6.9	16.7	41.7	-2.6	-5.0	-6.0	-4.6	-1.8	-3.4	-4.0	-3.7	-2.7	-6.5	-1.7	-4.0
Blood Eosinophil Count	6.3	48.2	92.2	8.5	7.4	6.3	4.8	-6.8	5.9	9.6	7.4	6.7	2.7	6.9	7.8
Respiratory disease	5.5	12.3	51.9	-1.0	-3.4	-5.5	-3.8	-5.5	0.0	-1.0	-1.1	-1.7	-7.2	1.3	-1.0
Tinnitus: Yes, now most or all of the time	4.8	5.6	10.0	2.8	2.0	1.2	2.1	-2.6	2.4	2.6	2.6	3.2	0.1	2.6	2.7
Ovarian Cancer	4.4	5.8	18.1	1.6	1.6	0.8	1.7	-3.2	2.3	2.7	2.4	4.2	-1.1	2.8	2.1
Medication: Amlodipine	4.2	5.9	8.6	2.8	2.5	1.4	0.9	-2.6	2.5	2.7	2.9	2.8	-0.6	2.9	2.8
Asthma	4.1	8.1	30.8	-0.8	-2.1	-4.3	-4.0	-4.7	1.2	-0.3	0.1	-0.7	-5.5	1.8	-0.1
Asthma (self-reported)	4.0	7.9	28.8	-0.6	-1.9	-4.3	-4.2	-4.4	1.4	-0.4	0.2	-0.8	-5.4	1.7	-0.1
Commuting to job workplace: Cycle	3.6	4.4	11.0	-2.6	-1.5	-1.2	-1.0	2.7	-2.4	-2.4	-2.1	0.5	0.4	-3.3	-2.5
Medication: Ventolin 100micrograms inhaler	3.3	4.3	14.8	-0.7	-2.2	-3.2	-2.4	-2.8	-0.3	-1.1	-1.0	-2.0	-3.9	0.5	-0.7
Medication: Blood pressure	3.2	6.1	15.6	4.0	2.0	1.3	1.0	-2.5	2.1	2.6	2.6	2.7	-1.3	3.1	2.9
Medication for hormone replacement therapy	2.9	3.2	5.7	-2.3	-1.6	-1.4	-2.2	2.1	-1.4	-2.4	-1.7	-1.2	-0.3	-1.9	-2.0
Hypothyroidism (self reported)	2.7	6.3	15.4	2.9	2.7	3.4	3.7	1.4	1.2	2.2	1.4	2.5	3.9	0.4	1.5
Hip circumference	2.7	11.5	24.6	3.8	3.8	3.8	5.0	-1.2	2.3	4.1	3.1	2.8	3.2	2.6	3.5
HDL Cholesterol	2.6	4.4	7.8	-1.9	-2.7	-2.7	-1.4	-0.5	-2.5	-2.0	-2.5	-0.2	-2.8	-1.4	-2.4
LDL Cholesterol	2.5	3.9	8.0	1.7	2.3	1.7	1.6	-1.3	2.3	2.8	2.4	1.7	1.1	2.0	2.1
Qualifications: CSEs or equivalent	2.5	3.3	8.6	1.5	2.2	2.9	1.8	0.8	1.3	1.7	1.7	1.4	2.3	1.2	1.8
Medication: Atenolol	2.5	3.1	7.8	2.8	1.9	0.9	0.1	-1.6	1.9	1.7	2.4	1.2	-0.3	1.9	2.2
Medication: Omeprazole	2.5	3.0	5.8	1.6	2.2	2.4	1.2	1.0	1.6	1.5	1.8	2.3	1.9	0.4	1.6
Triglycerides	2.4	4.0	7.1	2.1	2.4	2.1	1.3	-0.7	2.7	2.3	2.6	0.6	1.4	1.9	2.4
Financial difficulties in last 2 years	2.4	3.3	5.4	-1.8	-2.1	-1.6	-1.0	0.8	-2.3	-2.2	-2.3	-1.4	-0.4	-2.2	-2.2
Loneliness, isolation	2.4	3.3	7.2	-1.6	-2.2	-1.5	-1.2	1.1	-1.8	-2.0	-2.0	-2.7	-1.2	-1.5	-2.1
Blood Red Count	2.3	22.0	38.8	4.4	5.5	5.5	4.9	-2.4	4.2	6.2	5.0	2.5	4.2	4.0	5.7
Alcohol drinker status: Never	2.2	2.6	6.2	1.7	1.8	2.4	2.5	0.1	1.1	1.8	1.2	0.9	1.6	1.2	1.6
Schizophrenia vs Biploar Disorder	2.1	2.7	7.4	-2.7	-1.4	-1.2	-0.4	0.5	-1.4	-1.6	-1.7	-0.5	-1.8	-2.4	-2.1
Weight	2.1	10.2	19.4	3.7	3.5	3.3	4.4	-1.9	2.2	3.9	3.0	3.2	2.3	2.5	3.3
Ever highly irritable/argumentative for 2 days	2.1	2.5	8.8	-1.7	-1.2	-0.7	-0.3	0.8	-1.5	-2.3	-1.6	0.1	-1.1	-3.0	-2.2
Arm predicted mass (right)	2.1	10.7	16.2	2.9	3.7	3.2	3.8	-2.4	2.9	4.0	3.6	3.3	2.0	2.9	3.7
Arm fat-free mass (left)	2.1	10.8	16.2	3.3	3.9	3.4	3.6	-2.0	3.0	4.0	3.8	3.1	2.1	2.8	3.7
Arm predicted mass (left)	2.1	10.6	15.9	3.1	3.9	3.5	3.9	-1.8	2.9	4.0	3.7	3.0	2.4	2.6	3.6
Illnesses of siblings	2.0	2.9	5.3	-2.3	-1.3	-1.2	-1.7	2.2	-1.3	-2.0	-1.4	-2.1	0.5	-1.9	-1.6
Arm fat-free mass (right)	2.0	10.1	15.8	3.0	3.6	3.2	3.7	-2.2	2.8	4.0	3.5	3.0	2.0	2.9	3.6
Breast cancer (self-reported)	2.0	2.3	7.7	0.7	1.8	2.3	1.6	0.8	1.1	0.9	0.9	2.2	2.8	-0.1	0.6
Sitting height	1.9	13.4	19.9	2.6	4.4	4.2	3.1	-1.6	3.5	4.3	4.1	4.5	3.4	3.1	4.2
Emphysema/chronic bronchitis	1.9	2.2	4.3	-1.3	-1.6	-1.3	-0.7	1.4	-1.4	-2.1	-1.5	-1.8	-1.2	-1.4	-1.6
Basal metabolic rate	1.9	10.7	16.4	3.2	3.8	3.3	3.8	-2.1	2.7	4.0	3.5	3.3	2.3	2.8	3.6
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	4.7	0.9	2.1	2.1	1.3	0.1	1.7	1.5	1.8	2.2	1.4	0.4	1.3
Medication: Levothyroxine sodium	1.8	3.1	10.1	3.2	1.7	1.9	1.2	1.4	1.1	1.1	1.2	1.7	2.8	1.0	1.4
Trunk fat-free mass	1.8	10.4	16.7	2.8	3.8	3.0	3.3	-2.3	3.3	4.1	3.9	2.9	1.9	2.9	3.8
Age at last live birth	1.8	2.5	5.5	-0.6	-2.1	-1.1	-1.7	0.9	-2.3	-1.8	-2.1	-1.8	-1.2	-0.7	-1.6
Whole body water mass	1.8	10.1	15.8	2.9	3.8	3.2	3.6	-2.0	2.9	4.0	3.6	3.2	2.2	2.7	3.5
Mean Putamen Volume	1.7	2.0	6.7	0.2	1.6	1.8	1.0	2.3	1.3	0.4	1.1	0.7	2.6	-0.1	1.1
Diabetes (mother)	1.7	2.2	4.5	-0.9	-1.8	-1.7	-2.1	0.0	-1.4	-1.7	-1.4	-2.0	-1.6	-0.7	-0.9
Trunk predicted mass	1.7	9.9	15.6	2.8	3.8	3.0	3.2	-2.1	3.2	4.0	3.8	2.8	2.0	2.7	3.7
Standing height	1.7	16.6	28.7	3.3	4.8	3.9	3.6	-3.1	4.1	5.4	4.7	3.4	3.1	3.8	5.0
Exposure to tobacco smoke at home	1.7	1.9	4.3	-1.4	-1.1	-0.7	-0.2	1.1	-1.6	-1.6	-1.5	-2.1	0.2	-1.9	-1.7
Whole body fat-free mass	1.7	9.4	15.1	2.8	3.6	3.1	3.5	-2.0	2.8	3.9	3.5	3.0	2.1	2.7	3.5
Vascular/heart problems diagnosed by doctor	1.7	4.7	9.9	-2.8	-2.0	-1.3	-1.1	2.7	-1.7	-2.5	-2.0	-3.1	1.0	-2.4	-2.1
Pain experienced in last month	1.7	2.9	10.3	-1.0	-2.0	-2.5	-3.2	-0.1	-1.8	-1.7	-1.4	-1.4	-1.4	-0.6	-1.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.1	-1.3	-1.4	-0.6	-0.4	1.6	-2.0	-1.9	-1.8	-0.4	-0.8	-1.7	-1.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	7.8	2.6	1.5	2.2	2.8	0.9	0.5	1.5	0.7	1.8	2.4	0.8	1.1
Primary Biliary Cirrhosis	1.5	2.2	4.9	1.2	1.3	1.1	2.1	-1.7	1.5	2.0	1.3	0.2	0.1	2.2	1.3
Blood White Count	1.5	11.5	35.4	-2.4	-3.6	-3.9	-6.0	0.5	-2.2	-3.8	-2.8	-4.1	-3.5	-1.9	-2.9
High blood pressure	1.5	4.2	7.6	2.8	2.2	1.6	1.2	-2.1	1.8	2.5	2.1	2.7	-0.4	2.1	2.0
Mouth/teeth dental problems: Dentures	1.5	2.5	4.2	-2.0	-1.8	-1.4	-1.0	0.6	-1.0	-2.0	-1.7	-1.0	-2.0	-1.7	-1.8
Medication: Lansoprazole	1.5	1.7	4.3	-1.9	-1.2	-1.7	-0.9	-1.1	-0.7	-1.0	-0.9	1.0	-2.1	-0.8	-1.5
Birth weight of first child	1.5	2.7	4.5	-1.9	-1.9	-1.8	-1.3	0.5	-2.0	-2.1	-1.9	-1.4	-1.1	-1.5	-1.6
Gout (self-reported)	1.5	2.1	7.4	1.3	1.4	0.8	1.5	-1.6	1.2	1.6	1.4	2.7	0.0	1.5	0.9
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	8.5	1.1	2.0	2.3	1.4	1.6	1.2	1.5	1.0	0.0	2.9	-0.2	1.0
Basal cell carcinoma (self-reported)	1.5	1.8	4.2	-1.4	-0.7	-0.1	-0.4	1.2	-1.7	-1.2	-1.4	-2.1	0.5	-2.0	-1.6
HbA1C	1.4	1.5	3.8	1.1	1.3	1.3	1.2	0.3	1.1	1.3	1.3	1.2	1.9	0.9	1.2
BMI	1.4	8.4	31.6	3.0	3.0	3.7	5.6	0.5	1.0	2.8	2.0	2.8	3.4	1.2	2.0
Trunk fat mass	1.4	6.1	13.5	3.4	2.6	2.5	3.7	-1.4	1.3	2.8	2.0	2.8	1.9	1.8	2.3
Pulse wave reflection index	1.4	1.8	4.2	-0.7	-1.8	-1.6	-0.7	-0.7	-1.6	-1.4	-1.4	-1.1	-2.1	-0.7	-1.2
Pulse wave peak to peak time	1.4	1.6	5.7	0.3	1.6	1.7	2.0	0.9	0.7	0.8	0.8	0.9	2.4	-0.5	0.5
Financial situation satisfaction	1.4	1.7	5.1	-1.1	-1.4	-1.0	-0.1	0.5	-1.3	-1.7	-1.8	-0.2	-0.6	-1.6	-2.2
Cholesterol lowering medication	1.4	2.0	5.2	2.3	1.1	0.6	0.5	-1.5	1.5	1.3	1.6	0.6	-1.2	1.9	1.7
Waist Hip Ratio (WHR)	1.3	5.7	10.4	-1.0	-3.2	-2.9	-2.3	-0.2	-2.9	-2.5	-2.9	-2.2	-2.3	-2.0	-2.6
Hand grip strength (left)	1.3	3.4	6.6	0.0	1.5	0.5	-0.6	-2.6	2.4	2.4	2.3	2.1	-0.3	2.2	2.3
Leg fat-free mass (left)	1.3	6.8	10.9	2.7	3.0	2.9	3.3	-1.3	1.8	3.1	2.6	2.9	2.3	2.0	2.7
Current tobacco smoking	1.3	2.2	4.9	-2.2	-1.2	-1.0	-1.0	1.5	-1.2	-1.8	-1.3	-1.4	0.3	-2.2	-1.5
Serious illness, injury or assault to yourself	1.3	1.6	3.6	1.9	1.3	1.3	1.2	-0.2	1.1	1.1	1.4	1.2	1.0	1.4	1.4
Leg predicted mass (left)	1.3	6.7	10.0	2.7	3.0	2.9	3.2	-1.3	1.8	3.1	2.6	2.8	2.3	2.1	2.7
Happiness	1.3	1.6	6.9	-0.1	-0.4	0.5	-0.5	2.6	-1.2	-1.1	-1.0	-1.1	1.8	-1.4	-1.2
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.8	-0.5	0.6	1.6	0.7	2.4	-0.7	-0.5	-0.3	0.0	1.6	-2.1	-0.9
Friendships satisfaction	1.3	1.6	4.5	-0.3	-0.6	-0.2	-1.3	2.1	-0.5	-1.3	-0.8	-1.9	0.9	-2.0	-1.5
Smoking status: Current	1.3	2.1	5.1	-2.2	-1.2	-1.0	-0.7	1.4	-1.2	-1.7	-1.3	-1.3	0.3	-2.2	-1.6
Leg predicted mass (right)	1.3	6.7	11.1	2.6	3.0	3.0	3.3	-1.2	1.7	3.1	2.5	2.7	2.5	1.8	2.6
Crohns Disease (2012)	1.2	1.9	5.9	1.6	0.0	-1.2	-0.4	-2.2	1.2	1.1	0.9	-1.3	-1.0	2.4	1.3
Height	1.2	22.9	43.3	5.1	4.3	2.1	2.7	-6.6	4.9	6.0	5.3	3.2	-0.7	6.2	6.2
Cardiovascular Disease	1.2	4.1	9.5	3.1	2.1	1.5	0.8	-1.9	1.5	2.1	2.2	2.7	-0.4	2.2	1.9
Systolic blood pressure, automated reading	1.2	3.4	6.2	1.7	1.2	-0.4	-0.5	-2.5	2.2	2.0	1.9	2.2	-2.0	2.5	1.6
Hair/balding pattern: Pattern 4	1.2	2.9	6.1	2.5	1.4	0.9	1.6	-1.2	1.8	2.0	1.6	2.3	0.1	2.1	1.6
Wheeze or whistling in the chest in last year	1.2	2.1	9.1	1.1	-0.3	-1.3	-0.3	-2.9	1.3	0.6	0.8	0.1	-3.0	1.3	0.7
Medication: Allopurinol	1.2	1.6	3.3	1.4	1.6	1.1	1.3	-0.5	1.1	1.3	1.3	1.8	1.1	1.1	0.8
Whole body fat mass	1.2	5.0	12.7	3.0	2.3	2.2	3.6	-1.5	1.1	2.5	1.8	2.6	1.5	1.6	2.0
Leg fat mass (right)	1.2	4.5	11.1	2.8	2.1	2.1	3.3	-1.4	1.1	2.3	1.8	2.6	1.1	1.6	1.9
Hypertension (Self-reported)	1.2	3.4	7.0	2.6	2.0	1.3	0.7	-2.1	1.6	2.1	2.0	2.1	-0.6	1.8	1.9
Leg fat-free mass (right)	1.2	6.6	11.0	2.6	3.0	2.9	3.3	-1.2	1.6	3.1	2.5	2.7	2.5	1.8	2.6
Average weekly red wine intake	1.2	1.8	6.4	1.3	0.9	0.2	-1.3	-0.9	1.6	0.8	1.6	1.2	-0.3	2.5	1.7
Arm fat mass (left)	1.2	5.0	12.4	3.0	2.3	2.4	3.5	-1.0	1.0	2.4	1.8	2.6	1.7	1.6	2.0
Average weekly champagne plus white wine intake	1.2	1.6	3.2	-1.3	-1.3	-1.6	-1.7	-0.1	-1.0	-1.6	-1.2	-1.0	-1.8	-0.4	-1.3
Supplements: Calcium	1.2	1.3	2.2	-1.1	-1.3	-1.3	-1.1	0.0	-1.3	-1.3	-1.4	0.0	-1.0	-1.2	-1.5
Schizophrenia (2018)	1.1	2.2	5.1	-1.6	-1.0	-0.7	-0.9	2.2	-1.0	-1.8	-1.4	-1.6	-0.1	-2.3	-1.7
Irritable Bowel Disease (IBD)	1.1	2.5	4.8	1.5	1.1	-0.0	1.1	-1.5	2.2	2.0	1.8	-2.2	-0.1	1.8	1.9
Prostate Cancer	1.1	1.5	3.6	-1.1	-1.3	-1.2	-1.9	0.7	-1.3	-1.4	-1.4	-1.1	-0.7	-1.0	-1.1
Schizophrenia (2014)	1.1	2.5	6.6	-1.8	-1.5	-1.2	-1.0	1.5	-1.1	-1.9	-1.5	-2.6	-0.8	-1.9	-1.4
Pulse wave Arterial Stiffness index	1.1	1.2	4.7	-0.0	-1.2	-1.5	-1.8	-1.2	-0.4	-0.4	-0.5	-0.5	-2.2	0.8	-0.2
Arm fat mass (right)	1.1	4.6	11.2	2.9	2.2	2.3	3.3	-1.0	1.0	2.3	1.7	2.5	1.6	1.5	1.9
Heart disease (mother)	1.1	1.4	6.2	0.8	-0.9	-2.0	-0.6	-1.9	0.1	-0.2	-0.4	-0.0	-2.5	0.5	-0.3
Medication: Bendroflumethiazide	1.1	1.7	3.0	1.5	1.3	0.9	1.0	-1.3	1.2	1.6	1.4	1.7	-0.6	1.2	1.5
Leg fat mass (left)	1.1	4.3	11.4	2.7	2.1	2.1	3.4	-1.3	1.1	2.3	1.8	2.5	1.2	1.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.2	-1.1	-1.3	-1.1	-0.5	-0.1	-1.4	-0.8	-1.5	-1.5	-1.0	-0.6	-1.1
Medication: Paracetamol	1.0	1.7	5.7	-0.0	-1.1	-1.4	-2.4	-0.7	-0.6	-0.9	-0.6	-2.0	-2.3	0.4	-0.2
Pulse rate, automated reading	1.0	3.2	5.8	-2.4	-1.9	-2.0	-2.3	0.1	-1.2	-1.6	-1.5	-2.2	-1.8	-1.0	-2.0
Knee pain experienced in last month	1.0	1.6	4.3	1.6	1.5	1.1	2.1	-0.9	1.3	1.6	1.1	0.7	0.1	0.9	1.1
Medication for cholesterol	1.0	1.5	5.4	-2.3	-1.0	-0.7	0.3	0.3	-1.1	-1.0	-1.3	-1.6	0.4	-1.7	-1.3
Wears glasses or contact lenses	1.0	1.2	3.6	1.9	-0.5	-1.4	-0.4	-1.8	-0.3	0.3	-0.2	1.3	-1.4	1.2	0.1
Medication: Paracetamol	1.0	1.6	4.5	-0.6	-1.2	-1.4	-2.1	-0.8	-0.8	-1.0	-1.0	-1.9	-2.1	0.1	-0.5
Crohns Disease (2017)	0.9	1.9	5.9	1.3	0.4	-0.8	0.6	-2.4	1.5	1.6	1.2	-1.3	-1.1	1.7	1.3
Coronary Artery Disease (CAD)	0.9	1.1	4.8	0.6	0.3	-0.5	-2.2	-1.7	0.9	0.1	0.4	1.2	-0.0	1.3	0.5
Blood Platelet Count	0.9	10.4	18.1	-4.2	-4.0	-3.7	-3.9	0.6	-2.9	-3.5	-3.3	-2.3	-2.9	-2.2	-3.5
Systolic Blood Pressure	0.9	4.6	10.7	1.9	1.6	-0.1	-0.5	-2.6	2.5	2.0	2.5	3.3	-1.6	2.5	2.3
Lung FEV1/FVC ratio	0.9	4.3	8.2	0.5	2.8	2.8	2.6	0.9	2.2	2.6	2.3	0.2	2.9	0.3	1.9
Ever had hysterectomy (womb removed)	0.9	1.1	5.0	2.2	0.7	0.8	1.1	-0.4	0.5	0.8	0.9	-0.3	0.2	1.1	1.5
Waist circumference	0.9	3.2	8.1	2.8	1.8	1.9	2.8	-0.8	0.7	2.0	1.3	1.5	1.5	1.2	1.7
Number of live births	0.9	1.2	5.2	0.9	0.9	1.4	0.5	1.5	0.5	0.6	0.5	1.2	2.3	0.2	0.9
Pulse rate	0.9	1.6	3.9	-1.4	-1.5	-1.6	-1.9	-1.0	-0.9	-0.7	-1.0	-0.2	-2.0	0.1	-1.0
Noisy workplace	0.9	1.1	5.2	-1.6	-0.4	-0.1	-0.0	0.9	-0.6	-1.2	-0.8	-0.9	-0.1	-2.3	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.7	-1.7	-0.8	-0.8	-0.3	0.2	-0.8	-1.2	-0.9	0.2	-1.1	-1.2	-1.4
Shortness of breath walking on level ground	0.9	1.0	2.6	1.6	0.7	1.4	1.6	0.9	0.2	0.5	0.3	1.3	0.9	0.7	0.7
Medication: Blood pressure	0.9	1.7	5.1	0.8	1.5	1.0	0.0	-1.1	1.3	1.2	1.8	2.3	0.0	0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.8	0.7	1.5	1.5	1.4	-1.2	1.3	1.9	1.3	1.2	1.5	0.9	1.2
Ever had bowel cancer screening	0.9	1.1	5.3	1.4	0.3	0.2	0.3	-0.9	0.3	0.9	0.4	2.3	-0.9	1.6	0.6
Guilty feelings	0.9	1.4	2.7	1.6	0.8	1.4	1.6	0.4	0.7	0.8	0.8	-1.5	1.6	0.5	1.3
Diastolic blood pressure, automated reading	0.9	2.8	5.7	1.2	1.6	0.6	0.4	-2.4	2.1	2.3	1.9	1.2	-0.8	2.3	1.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.4	0.2	-0.7	-1.3	-1.2	-2.1	0.1	-0.1	-0.1	1.8	-1.8	-0.0	-0.2
Alzheimer’s Disease (in mother)	0.8	1.0	2.6	-0.2	1.1	0.8	0.6	-0.3	1.4	1.3	1.2	1.6	0.7	0.8	0.8
Ulcerative Colitis (UC)	0.8	1.6	3.7	1.1	1.0	0.4	1.0	-0.2	1.7	1.4	1.4	-1.9	0.4	1.3	1.6
Number of treatments/medications taken	0.8	1.4	3.3	1.5	0.8	0.2	-0.3	-1.3	1.0	0.8	1.2	1.8	-1.7	1.2	1.0
Relative age of first facial hair	0.8	1.6	3.2	0.8	1.4	1.6	1.2	-0.7	1.0	1.8	1.2	0.9	1.0	1.3	1.6
Medication: Co-codamol	0.8	0.9	2.4	-1.3	-1.1	-1.4	-0.3	-0.4	-0.4	-0.6	-0.7	-1.6	-1.4	-0.6	-0.6
Trunk fat percentage	0.8	3.3	8.9	2.8	1.7	1.9	3.0	-0.8	0.5	1.9	1.1	2.3	1.5	1.2	1.4
Hand grip strength (right)	0.8	2.2	7.0	-0.2	0.8	-0.1	-0.9	-2.6	1.9	1.8	1.6	1.3	-0.8	1.8	1.9
Heart attack	0.8	1.0	3.8	0.1	-0.5	-1.0	-1.3	-1.9	0.2	0.1	-0.0	1.8	-1.5	0.0	-0.1
Alcohol intake versus 10 years previously	0.8	1.1	2.8	-1.0	-1.1	-0.7	-0.0	0.2	-1.3	-1.2	-1.3	-0.2	-1.3	-1.7	-1.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	7.2	0.3	2.2	2.3	2.0	0.1	1.1	1.9	1.7	1.2	2.7	0.3	1.5
Length of working week for main job	0.8	0.9	3.1	1.8	0.7	1.2	0.7	0.1	0.2	0.9	0.5	-0.7	1.3	0.8	0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.7	1.7	0.5	0.9	1.1	-1.2	0.1	1.3	0.5	-0.8	0.7	1.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	6.3	-1.0	-1.3	-1.1	0.2	0.7	-1.0	-0.8	-1.3	-2.5	0.0	-0.8	-1.2
Birth weight	0.8	1.8	6.1	-1.5	-1.5	-1.3	-0.6	-0.8	-1.4	-1.1	-1.5	-2.5	-1.2	-0.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.8	0.2	0.9	0.6	1.4	-1.5	0.9	1.7	1.0	-0.7	0.1	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.9	0.3	0.8	0.3	0.9	-1.6	1.3	1.7	0.9	-0.2	-0.2	0.9	0.7
Suffer from ‘nerves’	0.8	1.2	3.9	2.0	0.9	0.5	-0.0	-0.4	1.1	1.0	1.4	-0.2	-0.2	1.8	1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.1	0.7	1.2	0.9	-0.7	0.3	1.3	1.2	1.4	0.6	0.6	0.8	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.8	-1.0	1.2	0.8	0.7	-1.3	1.1	1.3	1.2	1.3	-0.0	-0.2	0.5
Long-standing illness, disability or infirmity	0.8	1.3	4.8	2.2	0.5	0.0	-0.1	-1.6	0.9	0.9	0.8	0.4	-1.4	1.5	0.9
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.3	-1.1	-1.1	-1.4	0.4	-0.8	-1.0	-1.2	-0.6	-0.5	-0.9	-1.3
Fractured/broken bones in last 5 years	0.8	1.0	3.0	-1.7	-1.2	-1.0	-0.5	0.1	-0.9	-0.9	-1.0	-1.5	-0.3	-0.7	-0.7
Bipolar Disorder or Schizophrenia	0.7	1.7	7.7	-1.0	-0.9	-0.9	-0.7	1.3	-0.8	-1.3	-1.1	-2.8	-0.3	-1.5	-1.2
Depression (Nagel 2018)	0.7	1.1	2.0	1.2	0.7	0.3	1.4	-1.0	1.1	1.3	1.1	-0.9	0.2	1.4	1.3
Bipolar Disorder (2011)	0.7	0.7	2.0	0.0	0.9	0.4	0.3	-0.2	1.0	1.1	1.0	-0.6	0.0	1.4	1.2
Fasting Glucose	0.7	0.8	1.8	0.7	1.0	0.5	0.5	-0.8	1.2	1.3	1.2	0.7	0.4	0.9	0.9
High blood pressure (mother)	0.7	1.0	7.6	2.8	-0.3	-0.6	-0.4	-1.3	0.2	0.4	-0.1	-1.0	-0.5	0.5	0.5
Medication: Ramipril	0.7	0.9	8.2	0.7	0.6	1.0	0.3	-0.3	-0.3	0.5	0.4	2.9	0.5	-0.2	0.5
Worrier / anxious feelings	0.7	1.4	4.0	2.0	0.8	0.4	0.9	-1.3	0.9	1.3	1.2	-1.2	-0.4	1.5	1.3
Illnesses of mother	0.7	0.8	3.4	-1.1	0.8	1.1	0.5	1.8	0.2	-0.1	0.6	-0.5	1.5	-0.2	0.1
Breastfed as a baby	0.7	0.9	2.1	-1.0	-0.0	0.5	0.2	1.2	-0.9	-0.4	-0.9	-1.3	1.4	-1.4	-0.7
Body fat percentage	0.7	2.7	8.1	2.6	1.4	1.5	2.8	-0.9	0.4	1.6	1.0	2.1	1.0	1.1	1.2
Comparative body size at age 10	0.7	1.8	4.1	-0.7	-1.3	0.0	0.5	2.0	-1.9	-1.6	-2.0	-0.5	1.1	-1.3	-1.4
Overall health rating	0.7	1.5	7.6	2.8	1.0	0.6	1.4	-0.9	1.4	1.2	1.1	0.3	-0.3	0.7	1.1
Osteoarthritis (self-reported)	0.7	0.9	2.4	0.7	1.2	1.5	1.3	0.7	0.8	0.9	0.9	-0.2	0.9	0.1	1.0
Number of self-reported non-cancer illnesses	0.7	1.1	3.5	1.5	0.5	-0.3	-0.6	-1.5	1.2	0.8	1.0	0.5	-1.9	1.1	0.8
Ever smoked	0.7	1.3	5.0	-1.9	-0.1	0.6	-0.3	2.2	-0.4	-1.1	-0.3	-0.1	1.1	-1.6	-0.9
Leg fat percentage (left)	0.7	2.4	6.7	2.5	1.3	1.3	2.6	-1.2	0.7	1.6	1.2	1.7	0.2	1.3	1.3
Number of operations (self-reported)	0.7	1.1	2.9	0.6	1.1	1.7	1.0	1.4	0.3	0.4	0.8	1.2	1.7	-0.2	0.8
Average weekly beer plus cider intake	0.7	1.1	3.5	-1.0	-0.7	-1.1	-0.4	-0.2	-0.7	-1.0	-1.0	0.2	-1.3	-1.5	-1.9
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	-1.2	0.9	0.8	0.3	1.1	0.6	0.6	0.5	1.6	1.5	-0.4	-0.2
Major Depression (MDD)	0.6	0.7	1.7	0.4	1.3	0.8	1.0	-0.4	1.1	1.0	1.2	0.1	-0.1	1.0	0.5
Rheumatoid Arthritis	0.6	0.9	4.3	-0.5	0.1	0.4	2.1	-1.4	0.1	0.9	0.0	-1.6	0.3	-0.2	-0.3
Smoking Status	0.6	1.5	3.4	-1.8	-1.1	-1.2	-1.3	1.3	-0.7	-1.7	-1.0	-0.6	-0.7	-1.5	-1.1
Chronotype (morning person)	0.6	1.3	3.0	0.8	1.3	1.2	1.7	-1.3	0.4	1.7	0.8	-0.4	0.5	1.3	1.1
Tanning	0.6	7.6	13.2	-3.6	-3.1	-3.2	-2.8	1.0	-2.1	-3.3	-2.7	-2.2	-2.7	-2.6	-2.7
Townsend deprivation index at recruitment	0.6	0.8	3.2	-1.7	-0.1	-0.7	0.4	-1.5	0.0	0.3	0.1	-0.8	-1.8	0.1	-0.4
Body mass index (BMI)	0.6	2.6	8.8	2.4	1.5	1.7	3.0	-0.6	0.5	1.7	1.2	1.8	1.0	1.0	1.3
Medication: Simvastatin	0.6	0.8	3.0	0.8	0.6	0.3	-0.3	-1.1	0.8	0.4	1.0	1.1	-1.7	0.7	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.4	-1.2	0.4	0.7	-0.9	1.6	0.2	-0.2	0.4	-1.5	1.4	-0.3	0.4
Loud music exposure frequency	0.6	0.6	2.9	-1.7	-0.6	-0.4	-0.2	0.4	-0.7	-0.8	-0.8	-0.6	-0.4	-1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.6	0.1	1.0	1.7	0.7	1.1	0.0	0.3	0.3	1.1	2.1	-0.2	0.2
Headache pain in last month	0.6	1.0	3.0	1.1	1.1	1.7	1.1	0.9	0.8	0.5	1.0	0.5	0.7	0.9	1.1
Leg fat percentage (right)	0.6	2.2	6.1	2.5	1.1	1.1	2.3	-1.1	0.7	1.4	1.1	1.9	-0.0	1.4	1.3
Number of full brothers	0.6	0.8	2.8	-0.9	-0.6	-0.6	-0.6	0.5	-0.7	-1.2	-0.9	0.2	-0.8	-1.7	-1.2
Neck or shoulder pain in last month	0.6	0.9	2.5	1.3	1.0	1.6	1.1	0.0	0.8	0.6	0.9	0.7	0.5	0.8	1.0
Medication: Ibuprofen	0.6	0.8	2.3	-1.3	0.0	0.4	-1.3	1.5	-0.1	-0.5	0.0	-1.5	0.9	-0.4	0.1
Comparative height size at age 10	0.6	3.1	7.8	0.8	1.7	1.0	1.2	-2.8	1.7	2.6	2.1	1.0	0.3	1.9	2.2
Family relationship satisfaction	0.6	0.7	1.9	1.0	-0.4	0.0	0.1	1.3	-0.8	-0.9	-0.7	-0.4	0.7	-1.4	-1.1
Leg pain on walking	0.6	0.8	3.2	-0.2	1.1	1.4	1.8	0.3	0.4	1.0	0.5	-0.4	1.0	-0.5	0.0
Medication: Aspirin	0.6	0.7	3.0	0.9	0.4	-0.1	-1.5	-0.3	0.6	-0.3	0.7	1.7	-1.1	0.6	0.6
Arm fat percentage (left)	0.6	2.2	8.1	2.4	1.2	1.6	2.8	-0.3	-0.0	1.3	0.6	2.0	1.3	0.7	0.8
Qualifications: nursing, teaching	0.6	1.0	2.4	-1.5	-0.9	-0.3	0.5	0.2	-1.1	-0.7	-1.3	1.6	-0.0	-0.9	-1.4
Medication: Aspirin	0.6	0.8	4.0	1.1	0.6	0.1	-0.9	-0.7	0.7	0.1	0.8	2.0	-0.9	0.8	0.8
Miserableness	0.6	1.1	2.8	1.4	0.9	0.8	0.3	0.3	1.4	0.8	1.5	-0.6	-0.1	1.2	1.7
Worry (Nagel 2018)	0.5	1.0	4.9	2.2	0.2	0.1	0.7	-0.6	0.4	0.7	0.8	-1.3	-0.4	1.4	1.0
Reaction Time	0.5	1.0	2.9	-0.3	-1.7	-1.4	-0.2	-0.3	-1.1	-1.1	-1.3	-0.9	-0.9	-0.1	-1.0
Lupus	0.5	0.7	2.9	-0.9	0.6	0.7	-0.7	1.0	0.4	-0.1	0.8	-0.9	1.7	-0.6	0.7
Heel T-Score	0.5	4.3	40.8	1.4	1.0	1.4	1.6	1.3	0.0	0.3	0.5	6.4	1.2	0.1	0.0
Neuroticism	0.5	1.1	3.6	1.9	0.7	0.3	0.7	-0.3	1.1	0.7	1.1	-1.9	-0.2	1.0	1.1
Hair Pigment	0.5	14.1	23.7	3.5	4.2	3.9	4.6	-2.4	3.4	4.9	4.0	2.8	2.1	4.0	4.2
Average weekly spirits intake	0.5	0.7	2.8	0.4	-0.8	-1.3	-0.4	-1.1	0.1	-0.1	-0.2	-1.1	-1.7	0.4	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	0.8	0.6	-0.0	-0.0	-0.6	1.0	0.8	1.0	-1.3	-0.7	1.1	0.7
Hearing difficulty/problems: Yes	0.5	0.7	3.0	-0.8	-0.5	-0.6	0.6	-1.7	-0.4	0.3	-0.5	-1.4	-0.9	-0.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.7	1.2	-0.4	0.2	1.6	0.3	-1.1	-0.8	-0.8	0.2	-0.3	0.1	-0.3
Severe depression (siblings)	0.5	0.5	1.4	-1.2	0.0	0.7	0.9	0.3	-0.5	-0.2	-0.6	0.1	0.9	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.7	-0.9	-0.5	-0.3	-0.7	1.3	-0.6	-0.9	-0.5	-1.1	-0.3	-0.6	-0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	3.4	0.5	0.4	0.5	1.2	0.4	0.4	0.6	0.5	1.8	0.7	0.1	0.2
Stomach or abdominal pain in last month	0.5	0.6	2.1	-0.4	0.7	0.8	1.5	0.5	0.5	0.3	0.4	0.5	0.9	-1.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.8	-0.2	0.9	0.9	-0.4	1.4	1.0	-0.1	0.8	-1.7	0.7	-0.5	0.2
Hearing difficulty/problems with background noise	0.5	0.9	3.4	1.2	0.2	0.1	1.3	-1.9	0.3	1.2	0.4	-0.7	-0.4	0.9	0.6
Qualifications: None of the above	0.5	1.0	4.9	-0.7	-0.5	-1.3	-0.4	-1.4	0.3	-0.3	-0.0	-1.4	-2.2	-0.3	-0.3
Pain all over the body in last month	0.5	0.5	1.6	0.9	0.6	0.3	0.0	-0.2	1.2	0.6	1.1	0.1	-0.5	0.9	0.9
Father’s age at death	0.5	0.7	1.5	-0.5	-1.2	-0.7	0.3	0.8	-1.1	-0.9	-1.2	-1.2	0.5	-0.3	-0.7
Medication: Cholesterol lowering	0.5	0.7	5.8	0.6	0.7	0.8	-0.0	-0.3	0.4	0.2	0.8	2.4	-0.2	0.1	0.6
High blood pressure (siblings)	0.5	0.7	3.4	1.5	0.1	0.0	0.1	-0.9	0.2	0.3	0.3	1.8	-0.9	0.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.9	-0.6	-0.3	0.2	0.7	1.4	-0.9	-1.1	-0.6	0.5	0.6	-1.1	-0.9
Age at first live birth	0.5	0.8	3.6	-0.2	-1.2	-1.0	-1.9	0.3	-0.9	-0.9	-0.8	-0.1	-1.0	0.2	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	1.9	-0.2	-1.1	-0.7	1.4	-0.4	-1.3	-0.2	-1.4	-0.3	0.0	-0.7	-1.4
Migraine (self-reported)	0.5	0.6	1.8	-0.6	0.0	0.4	1.0	1.3	-0.3	-0.3	-0.4	0.9	1.2	-1.0	-0.6
Medication: Seretide 50 evohaler	0.5	0.6	2.1	-0.3	-0.1	-0.8	-0.7	-0.9	0.7	0.1	0.3	1.4	-1.4	0.5	0.3
Mean time to correctly identify matches	0.5	1.0	2.1	-0.0	-1.4	-1.2	0.2	-0.1	-1.1	-1.2	-1.4	-1.0	-0.8	-0.5	-1.1
Supplements: Vitamin C	0.5	0.6	1.4	-0.8	-0.6	-0.8	-1.2	0.4	-0.7	-0.9	-0.6	-1.1	-0.7	-0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.9	-0.3	-0.7	-0.4	-0.6	1.2	-0.6	-0.9	-0.8	-0.6	0.1	-1.4	-0.6
Ever taken oral contraceptive pill	0.5	0.6	3.0	-0.9	0.4	0.4	-1.0	1.7	0.5	-0.6	0.2	0.2	0.5	-0.8	-0.2
Hearing aid user	0.5	0.5	1.6	-0.5	-0.7	-1.0	-1.3	-0.3	-0.4	-0.6	-0.4	0.2	-1.2	-0.2	-0.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	0.4	0.9	1.4	0.6	0.7	0.1	0.6	0.4	0.7	0.7	1.2	0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.1	0.7	-0.0	-0.6	-0.4	-1.3	0.9	0.1	0.2	-0.1	-1.4	1.2	0.4
Irritability	0.5	0.9	3.1	1.1	-0.3	-0.8	0.1	-1.5	0.5	0.4	0.6	-0.8	-1.8	1.4	0.6
Bipolar Disorder (2018)	0.4	0.6	6.3	0.6	-0.2	-0.5	-0.1	-0.6	0.2	0.0	0.1	-2.5	-0.3	0.4	0.2
Neuroticism (Nagel 2018)	0.4	1.0	3.9	2.0	0.0	-0.1	0.6	-0.6	0.3	0.4	0.6	-2.0	-0.4	1.3	1.0
Alzheimer’s Disease (in father)	0.4	0.4	1.6	0.4	0.6	0.7	0.1	0.7	-0.2	0.2	-0.0	1.3	1.3	-0.1	0.2
Body Mass Index (BMI) (2010)	0.4	0.5	2.0	1.4	0.9	0.7	0.9	-0.0	0.6	0.4	0.6	0.2	1.0	0.1	0.2
Ulcerative Colitis	0.4	0.6	1.0	1.0	0.5	0.1	1.0	-0.1	0.8	0.7	0.6	-0.9	0.6	1.0	1.0
Angina	0.4	0.6	1.5	0.5	-0.8	-0.7	0.2	-0.4	-0.9	-0.8	-0.9	1.2	-0.7	-0.8	-0.7
Medication: Metformin	0.4	0.6	1.3	-1.1	-0.6	-0.5	0.2	0.2	-1.1	-0.6	-0.7	-0.4	-0.9	-1.0	-0.8
Fed-up feelings	0.4	0.8	2.1	0.9	0.7	0.5	0.3	-0.2	1.2	0.8	1.4	-0.5	0.0	1.3	1.4
Relative age voice broke	0.4	0.6	1.7	-1.3	-0.8	-0.9	-1.3	-0.8	-0.5	-0.3	-0.4	-0.1	-1.0	-0.4	-0.2
Taking other prescription medications	0.4	0.6	3.1	-0.1	-0.6	-1.3	-0.8	-0.8	-0.0	-0.3	-0.1	0.9	-1.8	-0.2	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	0.3	0.8	0.9	1.2	0.1	0.8	1.0	0.6	0.3	0.7	0.3	0.4
Number of incorrect matches in round	0.4	0.6	1.7	0.9	-0.5	-0.5	-0.9	1.1	-0.6	-1.3	-0.7	-0.7	-0.5	-0.2	-0.9
Alcohol usually taken with meals	0.4	0.6	2.1	0.7	-0.2	0.7	1.5	0.9	-0.9	-0.4	-0.6	-0.1	1.3	-0.4	-0.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.3	-0.7	0.5	0.0	0.6	-1.5	0.9	0.9	0.6	0.1	-0.6	0.6	0.5
Neuroticism score	0.4	0.9	2.6	1.6	0.5	0.2	-0.1	-0.1	1.1	0.6	1.2	-1.6	-0.5	0.9	1.1
Arm fat percentage (right)	0.4	1.4	5.5	2.1	0.9	1.2	2.3	-0.0	-0.2	0.9	0.3	1.5	1.0	0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.8	-1.9	-0.9	-0.6	-0.3	0.1	-1.1	-0.7	-1.1	-0.8	0.2	-0.9	-0.8
Depression (self-reported)	0.4	0.5	2.7	-0.7	0.4	0.5	-0.6	1.6	0.3	-0.3	0.1	1.4	0.5	-0.1	-0.2
Tense / ‘highly strung’	0.4	0.6	1.8	1.3	0.7	1.1	1.3	0.9	0.3	0.4	0.7	-0.6	0.1	0.1	0.3
Blood clot in the leg (DVT)	0.4	0.5	2.2	-0.3	0.1	0.3	0.7	0.6	-0.1	-0.1	-0.1	-1.5	1.0	-1.1	-0.0
Worry too long after embarrassment	0.4	0.7	1.2	0.8	1.1	0.9	0.3	0.7	0.8	0.4	1.0	-1.0	1.1	-0.4	0.8
Angina (self-reported)	0.4	0.5	1.0	0.3	-0.9	-0.7	-0.1	-0.3	-1.0	-0.8	-0.9	0.8	-0.7	-0.8	-0.7
Alcohol intake frequency.	0.4	1.0	2.8	0.6	1.0	1.6	1.7	1.2	0.6	0.7	0.4	-0.6	1.2	-0.4	1.0
Illnesses of siblings: Diabetes	0.4	0.4	1.3	1.1	0.5	0.7	0.9	-0.1	0.1	0.5	0.5	0.6	0.7	0.5	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	-0.9	-0.3	-0.2	-0.0	0.7	-0.5	-0.6	-0.6	-1.2	0.7	-1.2	-0.7
Commuting to job workplace: Walk	0.4	0.4	1.6	0.4	0.2	-0.3	-0.5	-1.0	0.7	0.6	0.6	-0.5	-0.5	1.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	-1.0	-0.9	-0.4	-0.5	0.5	-0.6	-1.2	-0.9	0.6	-0.4	-0.5	-0.7
Mineral and other dietary supplements	0.4	0.6	2.5	-1.1	-0.2	0.3	-0.4	1.6	-0.6	-0.4	-0.2	-0.4	1.2	-0.9	-0.3
Medication: Gliclazide	0.4	0.4	1.1	1.0	0.4	-0.0	1.0	-1.0	0.3	0.8	0.5	0.2	-0.1	0.7	0.5
High cholesterol (Self-reported)	0.4	0.7	3.2	0.1	-0.6	-0.6	-1.1	0.4	-0.4	-1.2	-0.4	-0.4	-1.8	-0.9	-0.4
Medication: Lisinopril	0.4	0.6	1.2	0.3	1.1	1.1	0.9	0.3	0.6	1.0	0.9	0.5	0.3	0.3	0.9
Illnesses of father: High blood pressure	0.4	0.4	1.6	1.3	0.7	0.4	0.7	-0.6	0.5	0.6	0.7	0.3	-0.4	0.5	0.7
Risk taking	0.4	0.6	1.9	-1.0	0.2	0.7	1.2	1.0	-0.2	0.4	0.2	-0.7	1.4	-0.5	0.0
Myopia	0.4	0.7	1.7	-1.2	-0.4	-0.9	-1.3	0.3	-0.4	-0.8	-0.7	-0.1	-0.7	-0.9	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.8	0.1	0.3	0.6	0.9	0.6	0.0	0.1	0.1	-1.4	1.2	-0.9	0.2
Heart disease (siblings)	0.4	0.4	1.2	0.5	0.5	0.4	1.1	-1.0	0.4	1.1	0.5	0.3	0.5	0.4	0.6
Depressed Affect (Nagel 2018)	0.3	0.6	2.8	1.7	0.1	0.1	0.2	0.2	0.5	-0.0	0.6	-1.0	-0.2	1.1	1.1
Neuroticism (2016)	0.3	0.4	2.2	0.7	-0.8	-0.7	0.6	-0.1	-0.4	-0.4	-0.4	-0.1	-1.5	-0.2	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.7	0.4	0.2	0.2	-0.6	1.3	0.6	-0.5	0.2	0.9	0.3	-0.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	-0.9	0.1	0.6	1.3	1.0	-1.0	-0.5	-0.5	0.5	0.3	-1.1	-0.8
Lung FVC	0.3	1.7	3.5	-1.7	-0.6	0.5	1.8	1.5	-1.3	-1.1	-1.1	-0.5	1.9	-1.7	-1.3
Sensitivity / hurt feelings	0.3	0.6	2.7	0.7	0.4	-0.3	-0.5	-0.5	0.8	0.6	0.8	-1.7	-1.1	0.5	-0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.6	0.5	1.0	1.0	0.7	0.6	0.2	0.6	0.1	0.0	0.4	0.4
Diabetes (father)	0.3	0.4	1.5	0.7	-0.6	-0.3	0.5	-0.4	-1.2	-0.1	-0.6	-1.1	0.3	-0.3	-0.2
Average weekly fortified wine intake	0.3	0.4	2.3	0.1	0.6	0.1	-0.9	0.2	0.6	0.1	0.4	-1.5	0.7	-0.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.6	-0.4	-0.0	-0.4	0.2	-0.5	0.3	0.5	0.2	-1.6	-0.7	0.6	0.0
Had menopause	0.3	0.3	1.7	0.3	-0.6	-0.5	-0.2	-0.7	-0.0	-0.6	-0.6	-0.4	-1.3	-0.2	-0.1
Had other major operations	0.3	0.4	2.5	0.7	-0.2	-0.1	1.1	-0.4	-0.2	-0.0	-0.1	-1.6	0.0	-0.1	-0.0
Forced vital capacity (FVC)	0.3	1.3	2.6	-0.0	1.4	1.4	1.4	-0.6	0.8	1.4	1.3	1.1	1.6	0.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	6.3	1.0	0.5	0.3	0.0	-0.3	0.2	0.3	0.5	2.5	-0.4	0.9	0.4
Diabetes (self-reported)	0.3	0.5	2.3	-1.0	0.1	0.0	1.5	-0.2	-0.8	-0.0	-0.2	-0.3	-0.4	-0.9	-0.7
Time employed in main current job	0.3	0.4	1.5	1.1	0.1	-0.1	-0.3	-0.6	0.7	0.4	0.1	-1.2	-0.4	0.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.8	0.7	1.0	1.1	1.1	0.3	0.3	0.5	-0.8	0.8	-0.1	0.0
Lung cancer (father)	0.3	0.4	1.5	-0.7	0.1	0.1	0.9	-1.2	-0.1	0.6	0.0	0.9	0.5	-0.2	0.1
Peak expiratory flow (PEF)	0.3	0.7	1.6	-0.2	1.2	0.9	0.4	-0.2	1.1	1.0	1.3	0.3	1.2	0.0	1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	0.8	0.6	0.2	-0.1	0.6	0.6	0.8	0.6	-0.1	0.9	0.5
Qualifications: College or University degree	0.3	1.0	4.5	-1.0	-1.0	-1.5	-2.1	-0.9	-0.7	-0.1	-0.3	-1.0	-0.8	0.3	0.1
Eye problems/disorders: None of the above	0.3	0.4	1.1	-0.2	0.8	0.8	0.4	0.8	0.4	0.2	0.6	0.4	1.1	-0.5	0.4
Chest pain or discomfort	0.3	0.5	2.1	1.3	-0.0	-0.7	-0.2	-0.7	0.8	0.1	0.4	0.0	-1.4	0.3	-0.1
Illnesses of father: Heart disease	0.3	0.5	1.8	-0.4	-0.5	-0.3	-1.3	0.6	-0.4	-1.1	-0.7	0.1	-0.3	-0.8	-0.5
Mood swings	0.3	0.5	2.2	0.6	-0.3	-0.5	-0.9	-0.3	-0.0	-0.0	0.2	-1.5	-1.4	0.7	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.8	-1.1	-0.0	0.1	1.3	0.3	-0.9	-0.3	-0.4	0.3	-0.5	-1.1	-0.8
Back pain experienced in last month	0.3	0.4	2.1	-0.4	0.1	0.7	1.0	1.4	0.1	-0.3	-0.0	-0.6	0.6	-0.5	-0.1
Osteoporosis (self-reported)	0.3	0.3	0.8	0.6	-0.6	-0.6	-0.9	-0.2	-0.8	-0.5	-0.6	-0.4	-0.5	0.5	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	2.3	-1.5	-0.4	-0.4	-1.0	0.7	0.0	-0.4	-0.1	-0.0	-0.2	-0.5	-0.3
Age started oral contraceptive pill	0.3	0.3	1.7	1.3	0.6	0.5	0.6	0.2	0.7	0.2	0.5	-0.1	0.4	0.6	0.5
Ever depressed for a whole week	0.3	0.3	1.7	-1.3	0.5	0.2	-0.1	-0.6	0.4	0.0	0.2	0.7	-0.9	-0.2	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.3	-0.7	0.5	0.7	0.4	1.1	0.3	-0.3	-0.0	0.6	0.3	-1.1	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	-1.4	-0.3	-1.0	-1.4	-0.6	-0.3	-0.1	-0.3	-0.8	-1.0	-0.0	-0.5
Age at First Birth	0.2	0.3	0.8	0.8	0.3	0.3	-0.3	-0.9	0.0	0.6	0.5	0.4	-0.1	0.6	0.8
Vitamin and mineral supplements	0.2	0.2	1.3	0.5	0.4	0.3	-0.2	0.0	0.6	0.3	0.6	1.1	0.3	0.1	0.5
Supplements: Zinc	0.2	0.2	0.7	0.9	-0.3	-0.2	0.8	-0.8	-0.5	0.1	-0.5	0.2	0.3	-0.1	-0.5
Maternal smoking around birth	0.2	0.3	0.8	-0.9	-0.3	0.0	-0.6	0.2	-0.2	-0.8	-0.6	0.1	-0.3	-0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	5.0	-0.1	0.1	-0.1	0.2	0.0	-0.2	-0.2	-0.1	2.2	-0.6	-0.3	-0.5
Multivitamins +/- minerals	0.2	0.2	0.8	0.6	0.2	0.9	0.8	0.7	-0.2	0.1	-0.0	0.2	0.6	-0.0	0.2
Past tobacco smoking	0.2	0.4	1.2	1.1	-0.3	-0.8	-0.2	-1.1	-0.3	0.4	-0.3	-0.7	-0.4	0.7	0.3
Nervous feelings	0.2	0.3	2.2	0.6	-0.0	-0.2	-0.7	0.3	0.4	0.0	0.5	-1.5	-0.5	0.2	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.9	0.1	0.5	0.3	0.6	-0.5	-0.2	-0.2	0.1	0.4	-0.6	-0.4
Mouth/teeth dental problems	0.2	0.3	0.8	0.3	-0.5	-0.9	-0.8	-0.7	-0.4	-0.1	0.1	-0.0	-0.6	0.7	0.4
Impedance of arm (right)	0.2	0.9	2.1	-0.7	-1.0	-0.9	-1.5	0.8	-0.8	-0.9	-1.2	-1.3	0.2	-0.6	-1.0
Falls in the last year	0.2	0.3	1.1	-0.6	-0.1	0.1	1.1	-0.8	-0.6	0.2	-0.4	-0.2	-0.4	-0.7	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	-0.3	-0.3	0.1	-0.6	0.8	0.3	-1.0	-0.2	-0.8	-0.3	-0.3	-0.0
Prospective memory result	0.2	0.3	0.9	0.1	-0.2	-0.6	-0.3	-1.0	0.5	0.3	0.4	-0.5	-0.9	0.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.5	-0.4	0.8	0.8	1.6	-0.2	0.2	0.9	0.5	1.3	1.5	-0.2	0.3
Glaucoma (self-reported)	0.2	0.3	0.6	0.6	0.4	0.7	0.8	0.4	-0.5	0.6	-0.1	0.0	0.6	0.8	-0.0
Forced vital capacity (FVC), Best measure	0.2	0.6	3.0	-0.7	0.5	0.3	1.0	-0.8	0.3	0.7	0.5	1.7	0.7	-0.0	0.2
Number of children fathered	0.2	0.2	2.0	1.4	-0.2	-0.3	0.4	-0.1	-0.0	0.1	0.0	-0.0	0.3	0.3	0.6
Health satisfaction	0.2	0.3	1.6	0.4	-0.1	0.4	0.6	1.3	-0.4	-0.4	-0.4	-0.2	0.3	-0.4	-0.5
Number of full sisters	0.2	0.3	0.7	0.3	-0.6	-0.5	-0.0	0.5	-0.8	-0.8	-0.6	0.2	-0.4	-0.4	-0.7
Had major operations	0.2	0.2	1.5	-0.3	0.0	-0.1	-0.7	-0.3	0.3	0.1	0.4	0.6	-1.2	0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.9	0.0	0.0	0.7	-0.0	0.2	-0.2	-0.1	0.2	0.4	-0.9	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.9	-0.3	0.2	0.4	0.9	-0.3	-0.0	0.2	-0.0	0.5	0.3	-0.7	0.2
Pack years of smoking	0.2	0.2	1.7	0.0	0.4	0.5	0.0	0.2	0.6	0.1	0.2	-1.3	0.2	-0.0	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.7	-0.4	0.5	0.1	-0.3	-0.3	0.1	0.5	0.2	-0.8	0.1	0.3	0.1
Pack years adult smoking proportion	0.1	0.2	1.5	-0.3	0.2	0.3	-0.3	0.4	0.4	-0.2	-0.0	-1.2	0.0	-0.1	0.1
Impedance of leg (right)	0.1	0.7	2.9	-0.8	-0.5	-1.0	-1.7	-0.6	0.7	-0.3	0.1	-0.6	-1.2	0.6	0.0
Age when periods started (menarche)	0.1	0.1	1.0	0.2	0.3	0.1	0.0	-0.1	0.2	0.2	0.5	1.0	0.3	0.0	0.2
Supplements: Glucosamine	0.1	0.1	0.3	-0.1	0.4	0.5	0.6	0.6	0.0	0.2	-0.0	0.1	0.4	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.9	-0.3	0.0	0.3	-0.7	1.0	-0.1	-0.3	0.2	0.2	-0.3	0.4	0.1
Impedance of leg (left)	0.1	0.6	2.3	-0.8	-0.5	-1.0	-1.5	-0.7	0.7	-0.1	0.2	-0.7	-1.1	0.5	0.1
Fluid intelligence score	0.1	0.3	1.0	-0.8	-0.0	-0.6	-0.8	-0.7	0.2	-0.1	-0.0	0.1	-1.0	0.3	-0.3
Impedance of arm (left)	0.1	0.6	1.6	-0.7	-0.9	-0.5	-0.9	0.8	-0.9	-0.7	-1.3	-0.6	0.5	-0.5	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.0	-0.9	0.1	-0.3	-1.0	0.1	0.7	-0.4	0.3	-0.1	-0.4	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.9	0.8	0.2	0.2	0.2	0.2	0.3	-0.0	0.0	0.1	1.0	-0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.2	1.2	0.2	-0.1	0.0	-0.6	0.0	-0.2	-0.1	0.0	-1.1	0.1	-0.5	0.2
Smoking status: Previous	0.1	0.2	0.9	-0.3	0.5	0.7	0.2	0.0	0.5	0.2	0.5	0.9	-0.0	0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.2	-0.3	-0.3	0.7	-0.8	-0.3	0.1	-0.3	0.6	-0.3	0.6	-0.5
Mother’s age at death	0.1	0.1	0.5	0.2	0.3	0.4	0.1	0.4	0.1	0.0	0.4	0.1	0.7	0.4	0.2
Commuting to job workplace: Public transport	0.1	0.2	0.6	-0.8	-0.3	-0.3	0.4	-0.5	-0.1	-0.0	-0.4	-0.6	-0.0	-0.2	-0.4
Medication: Atorvastatin	0.1	0.1	0.4	0.6	0.2	-0.1	-0.2	-0.4	0.1	-0.0	0.2	0.4	-0.6	0.2	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.9	-0.2	0.3	0.1	-0.6	1.0	0.2	-0.2	0.2	0.1	0.2	-0.0	-0.0
Impedance of whole body	0.1	0.5	1.7	-0.7	-0.8	-0.7	-1.3	0.4	-0.4	-0.6	-0.8	-0.8	-0.0	-0.2	-0.6

Hub : Genes

FAM114A1

Models

Trait associations