TWAS hub - EIF2B3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1350	0.0290	0.0e+00	0.212	0.150	0.193	0.189	0.203	2.4e-25	8.3e-18	5.9e-23	1.7e-22	3.3e-24
2	GTEx	Artery Tibial	0.0522	0.0278	7.1e-03	0.047	NA	0.028	NA	0.040	1.3e-04	NA	2.6e-03	NA	4.3e-04
3	GTEx	Brain Nucleus accumbens basal ganglia	0.1170	0.0590	9.2e-03	0.120	NA	0.016	NA	0.127	4.1e-04	NA	1.2e-01	NA	2.9e-04
4	GTEx	Cells EBV-transformed lymphocytes	0.1780	0.0690	1.2e-03	-0.006	NA	0.049	NA	0.007	5.8e-01	NA	1.1e-02	NA	1.8e-01
5	GTEx	Ovary	0.1420	0.0720	9.7e-03	0.147	NA	0.083	NA	0.079	1.8e-04	NA	4.6e-03	NA	5.5e-03
6	GTEx	Testis	0.1820	0.0650	6.3e-04	0.114	NA	0.065	NA	0.094	1.0e-05	NA	7.7e-04	NA	6.0e-05
7	METSIM	Adipose	0.0376	0.0157	5.1e-04	0.004	0.014	0.007	0.015	0.009	8.0e-02	3.0e-03	2.6e-02	2.2e-03	1.5e-02
8	ROSMAP	Brain Pre-frontal Cortex	0.0680	0.0222	1.0e-06	0.037	0.053	0.056	0.051	0.054	1.4e-05	2.3e-07	8.8e-08	3.6e-07	1.6e-07
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1740	0.0598	0.0e+00	0.146	0.180	0.179	NA	0.170	4.0e-16	8.6e-20	1.1e-19	NA	1.1e-18
10	TCGA	Brain Lower Grade Glioma	0.0682	0.0411	5.8e-06	0.043	0.046	0.039	NA	0.043	1.2e-05	5.3e-06	2.6e-05	NA	9.8e-06
11	TCGA	Prostate Adenocarcinoma	0.0797	0.0375	2.1e-08	0.082	0.072	0.081	NA	0.087	5.8e-09	5.0e-08	8.6e-09	NA	2.1e-09
12	TCGA	Thyroid Carcinoma	0.1560	0.0610	1.4e-11	0.126	0.127	0.127	NA	0.123	2.8e-12	2.2e-12	2.5e-12	NA	5.4e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Noisy workplace	7.0	8.7	12.6	-3.2	-2.5	-3.0	-2.9	-2.3	-2.4	-2.4	-3.6	-3.0	-3.3	-3.2	-3.3
Financial situation satisfaction	4.8	5.9	10.9	-3.0	-2.9	-3.3	-0.8	-2.5	-0.2	-2.5	-2.6	-2.5	-2.0	-3.0	-2.1
Number of self-reported non-cancer illnesses	4.5	7.9	14.9	-2.9	-3.9	-2.9	-1.2	-2.7	-1.9	-3.2	-2.9	-3.0	-2.6	-3.0	-2.6
Ulcerative Colitis (UC)	3.9	7.4	10.3	3.1	3.2	3.0	2.2	1.6	2.4	3.0	2.9	3.0	2.7	3.0	2.3
Allergy	3.7	8.6	13.2	3.1	3.6	2.8	1.9	2.0	2.8	2.9	3.0	3.5	3.3	3.1	2.7
Supplements: Glucosamine	3.6	4.7	10.7	-2.2	-2.4	-2.5	-2.1	-1.7	0.3	-3.3	-2.7	-2.2	-1.6	-2.2	-1.4
Hayfever, allergic rhinitis or eczema	3.5	7.6	12.5	-3.0	-3.5	-2.9	-2.0	-2.2	-1.7	-2.7	-2.7	-3.2	-3.0	-3.0	-2.3
Exposure to tobacco smoke at home	3.5	3.9	8.3	-1.9	-2.1	-1.9	-2.9	-1.5	-1.7	-1.5	-2.4	-1.9	-1.7	-2.0	-2.0
Long-standing illness, disability or infirmity	3.4	5.2	8.4	-2.3	-2.9	-2.2	-2.2	-1.3	-2.1	-2.0	-2.8	-2.5	-2.4	-2.3	-1.8
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	9.0	-1.9	-2.4	-2.1	-1.8	-3.0	-0.2	-2.1	-2.1	-1.8	-1.1	-1.9	-1.9
Handedness (chirality/laterality): Left-handed	3.0	3.6	5.1	2.0	1.7	2.1	1.8	2.3	1.6	1.4	2.2	1.8	2.0	2.0	1.9
Irritable Bowel Disease (IBD)	2.9	6.8	11.8	3.0	3.4	3.1	1.5	1.9	2.1	2.5	2.8	2.9	2.4	3.0	2.0
Average weekly fortified wine intake	2.9	3.4	6.7	-2.0	-1.6	-2.1	-1.3	-2.1	-1.3	-1.1	-2.6	-2.2	-1.5	-2.0	-1.7
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	6.9	-2.1	-2.2	-2.0	-0.9	-1.3	-2.1	-2.6	-1.9	-2.0	-1.7	-2.1	-1.9
Neck or shoulder pain in last month	2.9	4.2	7.7	-2.2	-2.5	-1.8	-0.8	-1.5	-2.8	-2.1	-1.4	-1.6	-2.7	-2.1	-2.2
Mineral and other dietary supplements	2.9	3.9	9.2	2.1	2.6	2.4	1.3	2.0	-0.0	3.0	2.0	1.8	1.2	2.1	1.3
Falls in the last year	2.8	3.8	6.1	-2.0	-2.5	-2.0	-1.5	-1.3	-1.5	-2.2	-2.4	-2.0	-1.6	-2.0	-1.8
Breast Cancer	2.7	6.6	28.5	2.2	3.7	2.4	1.8	1.7	0.4	5.3	2.6	1.7	1.7	2.2	1.7
Allergy or Eczema	2.7	7.1	11.6	-2.9	-3.4	-2.7	-1.9	-3.0	-1.5	-2.4	-2.6	-3.3	-2.5	-2.9	-2.3
Glaucoma (self-reported)	2.5	2.9	4.2	-1.7	-1.8	-1.5	-1.6	-2.0	-1.5	-1.0	-1.8	-2.0	-1.8	-1.7	-1.9
Number of operations (self-reported)	2.5	3.7	6.8	-2.1	-2.6	-2.1	-0.9	-2.0	0.0	-2.2	-2.1	-1.9	-1.6	-2.0	-2.0
Hypothyroidism (self reported)	2.4	5.6	8.5	-2.5	-2.4	-2.5	-2.4	-2.7	-1.2	-1.3	-2.9	-2.5	-2.3	-2.5	-2.3
Leg pain on walking	2.4	3.1	5.8	-1.6	-1.4	-1.3	-2.3	-1.2	-2.2	-0.5	-2.1	-1.4	-2.4	-1.6	-2.2
Fasting Glucose	2.3	2.7	4.3	-1.9	-2.1	-2.1	-0.8	-0.9	0.5	-1.9	-1.8	-1.4	-1.4	-2.0	-1.9
Time employed in main current job	2.3	2.7	8.7	2.1	1.7	2.4	0.1	0.8	-0.0	2.9	1.1	1.6	1.1	2.1	0.7
Average weekly spirits intake	2.2	2.7	8.8	-1.6	-1.5	-1.9	-1.1	-3.0	0.3	-2.2	-1.6	-1.5	-0.8	-1.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	5.9	1.6	1.7	1.7	1.2	1.5	1.0	2.4	1.9	1.6	1.4	1.6	1.2
HbA1C	2.1	2.3	7.6	-1.4	-1.1	-1.4	-2.8	-2.1	-0.4	-0.9	-1.7	-1.6	-1.2	-1.4	-1.1
Birth weight of first child	2.1	3.9	16.5	1.9	2.3	2.0	1.9	-0.1	0.9	4.1	1.9	1.2	1.7	1.8	1.3
Migraine (self-reported)	2.1	2.6	3.5	-1.9	-1.7	-1.8	-1.6	-1.4	-0.7	-1.2	-1.6	-1.9	-1.5	-1.9	-1.7
Ever used hormone-replacement therapy (HRT)	2.0	2.6	4.7	-1.8	-2.2	-1.8	-0.3	-0.7	-1.5	-2.1	-1.5	-1.4	-1.5	-1.8	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.0	-1.9	-1.8	-1.7	-1.9	-0.5	-1.7	-1.6	-2.0	-2.1	-2.2	-1.9	-1.9
Happiness	2.0	2.4	4.7	1.7	1.5	1.6	1.5	0.7	0.6	1.5	2.2	1.8	1.6	1.7	1.6
Supplements: Fish oil (including cod liver oil)	2.0	2.6	7.1	-1.9	-2.0	-2.0	-0.6	-1.4	-0.3	-2.7	-1.2	-1.6	-1.3	-1.9	-1.1
Mean time to correctly identify matches	1.9	3.6	11.6	1.9	1.8	2.2	1.5	1.8	0.3	3.4	2.1	1.9	1.3	2.0	1.0
Irritability	1.9	3.2	6.6	-2.1	-1.5	-1.9	-2.6	-0.4	-1.5	-0.5	-1.7	-1.7	-2.1	-2.1	-2.0
Age started oral contraceptive pill	1.9	2.4	13.2	1.4	1.3	1.4	1.0	-0.6	0.4	3.6	1.7	0.9	1.2	1.5	0.9
Illnesses of mother	1.8	2.2	7.8	1.5	2.1	1.7	-0.2	1.1	-0.2	2.8	1.5	1.1	0.9	1.5	0.9
Knee pain experienced in last month	1.8	2.8	8.0	-1.6	-1.9	-1.7	-0.7	-2.8	-0.4	-1.6	-2.0	-1.8	-0.9	-1.6	-1.6
Ovarian Cancer	1.7	2.2	7.5	-1.5	-1.2	-1.5	-0.8	-2.7	-0.5	-0.8	-2.0	-1.8	-0.9	-1.5	-1.2
Relative age voice broke	1.7	2.6	5.0	1.7	1.1	1.8	1.8	1.7	1.3	1.2	2.0	2.2	1.4	1.7	0.6
Pulse rate	1.7	2.9	13.2	1.5	1.2	1.8	1.2	3.6	-1.2	1.6	1.4	2.1	0.6	1.5	0.5
Back pain experienced in last month	1.7	2.4	6.3	-1.4	-0.9	-1.3	-2.5	0.6	-1.7	-1.4	-1.9	-1.4	-2.1	-1.4	-1.3
Ever depressed for a whole week	1.7	2.2	3.5	1.6	1.5	1.5	1.4	1.6	1.2	1.2	1.4	1.9	1.4	1.5	1.3
Blood Red Count	1.6	15.4	60.4	3.7	5.5	3.7	1.3	1.6	0.7	7.8	4.1	2.7	3.5	3.7	3.6
Severe depression (siblings)	1.6	1.8	3.2	1.6	1.4	1.6	0.9	0.3	1.3	0.5	1.1	1.4	1.8	1.5	1.6
Medication: Simvastatin	1.6	2.3	3.0	-1.6	-1.5	-1.5	-1.2	-1.4	-1.3	-1.3	-1.7	-1.7	-1.6	-1.6	-1.6
Number of full brothers	1.6	2.1	4.2	1.6	1.2	1.9	1.2	1.6	0.1	1.1	2.0	1.5	1.2	1.6	1.2
Reaction Time	1.5	2.8	8.0	1.6	1.6	1.7	1.6	1.7	0.5	2.8	1.9	1.6	1.2	1.6	1.1
Angina	1.5	1.9	4.9	-1.4	-1.7	-1.1	-0.5	0.3	-2.2	-1.6	-0.9	-1.3	-1.7	-1.3	-1.6
Financial difficulties in last 2 years	1.5	2.0	3.2	-1.5	-1.7	-1.5	-1.3	-0.2	-0.9	-1.7	-1.8	-1.6	-1.6	-1.5	-1.1
Commuting to job workplace: Public transport	1.5	1.8	3.8	1.4	0.9	1.2	1.5	-0.4	1.6	1.1	1.7	1.0	1.9	1.4	1.5
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.7	1.6	0.9	1.5	0.4	1.0	1.6	0.4	1.6	1.4	1.4	1.5	1.6
Crohns Disease (2017)	1.4	3.0	7.2	2.1	2.7	2.3	0.3	1.8	0.8	1.3	1.6	1.9	1.1	2.1	1.0
Blood Platelet Count	1.4	15.7	78.7	-2.8	-6.6	-3.3	1.0	0.6	3.8	-8.9	-3.3	-0.7	-2.3	-2.8	-2.9
Trunk fat percentage	1.4	5.8	10.3	-2.6	-3.2	-2.6	-1.9	-1.8	-1.2	-2.5	-3.0	-2.3	-2.2	-2.6	-2.4
Current tobacco smoking	1.4	2.2	12.2	-1.1	-2.1	-1.3	0.6	-1.1	0.4	-3.5	-1.7	-0.6	-0.7	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	6.3	-2.1	-1.4	-2.0	-1.5	-1.4	-2.0	-2.5	-1.1	-1.9	-1.8	-2.0	-0.8
Breastfed as a baby	1.4	1.7	2.9	-1.4	-1.6	-1.6	-0.9	-1.5	-0.4	-0.9	-1.6	-1.7	-0.9	-1.4	-0.9
Loud music exposure frequency	1.4	1.5	5.4	-0.9	-0.2	-0.7	-2.3	-0.2	-2.0	-0.6	-1.3	-0.5	-1.4	-1.0	-1.5
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	4.0	-1.6	-1.5	-1.6	-1.8	-1.8	-1.4	-1.0	-2.0	-1.7	-1.7	-1.7	-1.7
Body fat percentage	1.4	5.5	10.4	-2.4	-3.2	-2.5	-1.8	-1.8	-1.1	-2.9	-3.0	-2.1	-2.0	-2.4	-2.3
Smoking status: Previous	1.4	2.2	3.5	1.7	0.9	1.6	1.7	0.0	1.4	1.4	1.3	1.9	1.8	1.7	1.1
Heart disease (siblings)	1.4	1.7	4.8	1.4	1.2	1.1	1.1	0.4	1.7	0.6	1.2	0.8	1.6	1.4	2.2
Prostate Cancer	1.3	1.9	3.0	1.6	1.0	1.4	1.3	0.6	1.5	0.6	1.6	1.7	1.7	1.6	1.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.3	-1.4	-1.6	-1.3	-0.6	-1.3	-1.0	-0.7	-1.7	-1.8	-1.1	-1.4	-1.1
Stomach or abdominal pain in last month	1.3	1.6	6.1	-1.1	-1.5	-0.8	-0.2	0.8	-2.5	-1.3	-0.9	-0.7	-1.6	-1.0	-1.3
Medication: Levothyroxine sodium	1.3	2.3	4.6	-1.6	-1.3	-1.7	-1.2	-2.1	-0.5	-0.5	-2.0	-1.7	-1.3	-1.6	-1.4
High blood pressure (mother)	1.3	1.9	8.1	-1.3	-1.8	-1.3	0.1	-0.5	-0.9	-2.8	-0.8	-1.3	-1.3	-1.3	-1.0
Nervous feelings	1.3	2.5	4.4	1.7	2.1	1.6	0.4	1.9	1.5	1.5	1.4	1.3	1.2	1.7	1.9
Hair/balding pattern: Pattern 2	1.3	1.6	7.7	1.0	1.1	1.1	1.1	1.4	-0.1	2.8	1.3	1.3	0.9	1.0	0.1
Diabetes (self-reported)	1.3	2.0	3.5	-1.2	-1.8	-1.1	-0.7	-1.7	-1.9	-1.6	-1.2	-1.4	-1.1	-1.2	-1.4
Hip circumference	1.3	5.8	9.8	-2.3	-2.1	-2.2	-2.8	-2.7	-2.0	-1.5	-3.1	-2.8	-2.1	-2.3	-2.4
Medication: Amlodipine	1.3	1.8	6.2	1.2	1.4	1.3	0.6	2.5	0.6	1.1	1.7	1.3	0.5	1.3	1.3
Age at last live birth	1.3	1.9	5.1	1.4	1.4	1.4	0.4	1.5	1.4	2.3	1.1	1.3	1.1	1.4	1.2
Alcohol drinker status: Never	1.3	1.5	4.4	-0.8	-1.5	-0.8	-1.1	-1.1	-1.9	-2.1	-1.3	-0.6	-0.8	-0.8	-0.8
Ulcerative Colitis	1.2	1.8	3.6	1.4	1.4	1.4	0.9	-0.0	1.4	1.9	1.5	1.2	1.5	1.4	1.3
Lung FEV1/FVC ratio	1.2	5.9	19.0	-2.4	-1.9	-2.6	-2.7	-0.2	0.7	-4.4	-3.2	-2.1	-1.9	-2.4	-1.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.8	1.3	0.6	1.4	1.7	1.2	-0.4	1.3	1.3	1.2	1.0	1.4	1.1
Trunk fat mass	1.2	5.4	8.8	-2.5	-2.7	-2.5	-2.1	-2.1	-1.1	-2.1	-3.0	-2.4	-2.1	-2.5	-2.3
Alcohol usually taken with meals	1.2	2.0	4.4	-1.6	-1.0	-1.6	-2.0	-1.2	0.4	0.5	-1.3	-2.1	-1.4	-1.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.0	-1.6	-1.2	-1.3	-1.4	0.4	-1.6	-0.7	-1.1	-1.4	-2.0	-1.6	-1.6
Worry too long after embarrassment	1.2	2.1	10.1	1.2	1.9	1.3	0.0	0.9	1.1	3.2	1.3	0.7	1.2	1.2	1.1
Medication: Omeprazole	1.2	1.4	2.8	1.3	1.2	1.1	-0.1	1.0	1.7	-0.1	0.8	1.5	1.7	1.3	1.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.3	-0.8	-0.2	-0.4	-1.7	0.4	-2.1	0.1	-1.0	-0.6	-1.8	-0.8	-1.8
Arm fat percentage (left)	1.2	4.8	8.2	-2.3	-2.9	-2.4	-1.6	-2.2	-0.7	-2.7	-2.6	-2.2	-1.7	-2.3	-1.8
Ever had bowel cancer screening	1.2	1.4	2.9	1.6	0.0	1.7	0.6	1.0	0.6	1.1	1.2	1.1	1.1	1.6	1.3
Diabetes diagnosed by doctor	1.2	2.0	5.2	-1.2	-1.9	-1.3	-0.3	-1.7	-0.9	-2.3	-1.6	-1.4	-0.9	-1.2	-1.2
Smoking status: Current	1.2	1.9	10.3	-1.0	-1.9	-1.3	0.5	-1.1	0.5	-3.2	-1.6	-0.6	-0.7	-1.0	-0.8
Eye problems/disorders: Glaucoma	1.2	1.5	2.4	-1.2	-1.2	-1.1	-0.5	-1.4	-1.1	-0.9	-1.4	-1.3	-1.2	-1.2	-1.6
Medication: Atorvastatin	1.2	1.5	3.2	1.3	0.7	1.2	1.8	-0.4	1.2	0.8	1.3	1.0	1.5	1.2	1.6
Leg fat percentage (left)	1.2	4.5	10.9	-1.9	-3.0	-2.0	-1.8	-1.6	-0.8	-3.3	-2.6	-1.4	-1.6	-1.9	-2.2
Number of treatments/medications taken	1.1	2.0	6.4	-1.2	-2.5	-1.3	0.7	-1.0	-0.8	-2.5	-1.4	-1.1	-0.7	-1.3	-1.1
Pack years adult smoking proportion	1.1	1.7	5.4	-1.1	-1.5	-1.4	-0.5	-1.6	0.6	-2.3	-1.8	-1.3	-0.6	-1.0	-0.5
Arm fat percentage (right)	1.1	4.4	7.7	-2.1	-2.8	-2.2	-1.6	-2.0	-0.8	-2.6	-2.5	-2.1	-1.6	-2.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.4	-0.9	-1.7	-0.9	1.7	-0.3	-1.3	-2.1	-0.2	-0.5	-0.5	-0.9	-0.6
Emphysema/chronic bronchitis	1.1	1.2	2.8	-0.9	-1.4	-1.0	-0.8	-1.7	-0.3	-1.6	-1.5	-1.2	-0.7	-0.9	-0.4
Medication: Seretide 50 evohaler	1.1	1.3	6.5	-0.5	-0.9	-0.3	0.1	1.5	-2.6	-1.3	-0.3	0.4	-1.3	-0.6	-1.3
Whole body fat mass	1.1	4.7	7.9	-2.3	-2.5	-2.2	-1.9	-2.1	-1.1	-2.2	-2.8	-2.3	-1.8	-2.2	-2.2
Chest pain or discomfort	1.1	1.7	4.5	-1.1	-1.2	-1.0	-0.2	-2.1	-1.4	-1.8	-1.1	-1.8	-0.7	-1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.2	1.3	1.2	1.1	0.2	0.3	1.7	0.1	0.8	1.3	1.8	1.3	1.3
Waist Hip Ratio (WHR)	1.0	4.4	11.1	2.4	1.6	2.1	2.7	0.7	1.1	0.7	1.9	3.3	2.6	2.4	1.8
Medication: Co-codamol	1.0	1.2	3.3	-1.1	-1.3	-1.1	-0.4	-1.1	-0.1	-0.8	-1.8	-1.5	-0.8	-1.1	-0.9
Diabetes (mother)	1.0	1.3	4.0	1.3	-0.1	1.3	2.0	0.5	0.8	0.5	1.1	1.5	0.9	1.3	0.8
Serious illness, injury or assault to yourself	1.0	1.2	3.2	1.3	1.2	1.2	1.3	0.7	0.6	-0.4	0.9	0.5	1.3	1.3	1.8
Multivitamins +/- minerals	1.0	1.2	7.8	-0.6	-0.9	-1.0	-0.4	-1.4	0.5	-2.8	-1.2	-0.6	0.3	-0.7	0.1
Arm fat mass (right)	1.0	4.2	6.8	-2.1	-2.3	-2.2	-1.6	-2.4	-0.8	-2.1	-2.6	-2.2	-1.6	-2.1	-1.9
Angina (self-reported)	1.0	1.3	3.3	-1.1	-1.4	-0.9	-0.3	0.5	-1.8	-1.3	-0.6	-1.0	-1.4	-1.1	-1.3
Had major operations	1.0	1.2	5.2	-0.7	-1.8	-1.0	0.8	-0.3	1.7	-2.3	-0.7	-0.3	-0.0	-0.7	-0.2
Family relationship satisfaction	1.0	1.2	3.0	1.3	1.2	1.2	0.4	0.4	1.5	1.7	0.7	1.1	1.1	1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.6	0.8	1.0	0.9	1.3	1.9	-0.7	1.3	1.0	0.6	0.5	0.8	1.0
Mother’s age at death	1.0	1.3	2.8	-1.4	-1.7	-1.4	-0.4	-0.8	0.5	-1.0	-0.8	-1.5	-0.8	-1.4	-1.3
Medication: Lisinopril	1.0	1.3	2.6	-1.1	-1.3	-0.9	-0.9	-0.0	-1.4	-0.7	-0.9	-1.2	-1.4	-1.2	-1.6
Pack years of smoking	1.0	1.4	4.8	-0.9	-1.4	-1.2	-0.2	-1.7	0.6	-2.2	-1.6	-1.2	-0.5	-0.8	-0.5
Leg fat mass (left)	1.0	4.0	6.9	-1.9	-2.3	-1.9	-2.1	-1.9	-0.9	-2.3	-2.6	-1.8	-1.6	-1.9	-2.1
Coronary Artery Disease (CAD)	0.9	1.1	5.2	0.8	0.3	-0.2	0.7	-1.1	2.3	-1.4	0.2	-0.2	1.1	0.6	1.4
Hearing difficulty/problems: Yes	0.9	1.4	7.4	0.3	1.2	0.7	-0.7	1.4	-2.1	2.7	0.6	0.1	-0.7	0.4	-0.3
Ever had hysterectomy (womb removed)	0.9	1.0	5.5	-0.7	-1.3	-1.0	-0.1	-1.6	0.7	-2.3	-0.6	-0.4	0.0	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	4.9	-1.5	-0.7	-1.5	-1.6	-0.8	-2.2	-2.2	-0.8	-1.2	-1.1	-1.4	-0.4
Past tobacco smoking	0.9	1.7	4.0	-1.4	-0.2	-1.1	-1.8	0.4	-2.0	-0.1	-0.7	-1.8	-1.7	-1.4	-0.9
Pulse wave Arterial Stiffness index	0.9	1.0	5.5	1.0	0.3	0.6	0.3	-0.6	2.3	0.9	-0.4	1.0	1.4	1.0	0.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.5	-1.1	-1.9	-1.1	-0.4	-0.7	0.3	-0.8	-1.1	-0.7	-1.1	-1.0	-1.0
Leg fat percentage (right)	0.9	3.4	9.5	-1.6	-2.8	-1.7	-1.3	-1.7	-0.1	-3.1	-2.2	-1.0	-1.0	-1.6	-1.8
Comparative body size at age 10	0.9	2.4	7.6	-1.7	-1.6	-2.1	0.6	-2.8	0.8	-1.7	-1.5	-1.6	-0.5	-1.7	-0.3
Number of children fathered	0.9	1.0	1.6	1.2	0.7	1.2	-0.5	1.1	0.8	-0.5	1.2	1.0	1.0	1.3	0.9
Shortness of breath walking on level ground	0.9	1.1	4.4	-1.0	-0.6	-0.8	-1.0	0.0	-2.1	-0.5	-0.8	-1.2	-1.3	-1.0	-1.0
Pulse rate, automated reading	0.9	3.0	19.1	0.9	0.2	1.6	1.0	4.4	-2.2	1.8	1.0	1.2	-1.0	0.9	-0.1
Mood swings	0.9	1.6	2.3	-1.4	-1.4	-1.2	-1.3	-0.4	-0.7	-1.2	-1.5	-1.4	-1.3	-1.4	-1.4
Commuting to job workplace: Walk	0.9	1.0	2.4	1.0	1.0	0.9	0.2	1.3	1.0	0.4	1.4	0.4	1.0	0.9	1.5
Eye problems/disorders: Cataract	0.9	1.0	2.3	1.1	0.4	1.5	0.7	1.5	-0.9	0.4	1.0	1.3	0.6	1.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.0	1.4	1.4	1.4	1.2	0.9	1.2	0.8	1.0	1.3	1.3	1.4	1.0
High cholesterol (Self-reported)	0.9	1.5	3.3	-1.3	-1.6	-1.3	-0.7	-1.8	-0.4	-1.5	-1.0	-1.3	-0.9	-1.2	-0.9
Ever smoked	0.9	1.5	7.6	0.9	-0.4	0.5	1.3	-1.2	2.8	-1.0	-0.0	1.3	1.6	0.9	0.6
Pain experienced in last month	0.9	1.4	4.5	0.9	1.1	0.7	0.6	0.0	2.1	1.6	1.1	1.1	1.5	0.9	1.4
Alzheimer’s Disease (including proxy)	0.8	1.1	3.1	0.5	0.7	0.2	1.8	1.2	1.7	-1.0	0.8	0.6	1.0	0.6	1.4
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.2	-1.0	-1.3	-1.1	-1.0	-0.7	0.8	-1.5	-0.5	-0.8	-0.6	-1.0	-0.9
BMI	0.8	4.9	12.2	-2.0	-2.1	-1.9	-1.6	-1.6	-1.5	-3.5	-3.0	-2.2	-2.0	-2.0	-2.2
Respiratory disease	0.8	1.7	8.5	-0.8	-1.2	-0.5	-1.1	-0.6	-2.9	-1.3	-1.0	-0.8	-1.4	-0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.6	-0.9	-0.8	-0.7	-0.5	-0.2	-1.0	-0.5	-1.1	-0.7	-1.6	-0.9	-1.4
Alcohol intake versus 10 years previously	0.8	1.3	3.2	1.4	0.4	1.5	1.8	0.0	-0.7	0.0	0.8	1.5	1.1	1.3	1.0
Gout (self-reported)	0.8	1.1	3.5	-0.7	-0.7	-0.4	-0.9	-1.5	-1.6	0.5	-0.9	-0.8	-0.8	-0.7	-1.9
High blood pressure (siblings)	0.8	1.2	3.7	-1.0	-1.3	-1.2	-1.3	0.6	0.9	-1.9	-1.3	-0.8	-0.7	-1.0	-0.1
Eye problems/disorders: None of the above	0.8	0.9	2.9	-0.8	0.0	-1.1	-1.0	-1.3	1.7	0.9	-0.7	-1.2	-0.0	-0.8	0.4
Leg fat mass (right)	0.8	3.3	5.8	-1.7	-2.2	-1.8	-1.8	-1.9	-0.4	-2.3	-2.4	-1.6	-1.3	-1.7	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-1.2	-1.4	-1.2	-0.3	-0.1	-0.3	-0.6	-1.1	-0.9	-0.8	-1.2	-1.2
Schizophrenia (2014)	0.7	1.6	3.1	1.3	1.0	1.2	1.8	1.5	0.9	0.6	1.5	1.4	1.0	1.3	1.2
Smoking Status	0.7	1.6	5.3	1.1	-0.2	0.8	2.3	-0.5	1.8	-1.0	0.3	1.8	1.4	1.2	0.9
Hand grip strength (left)	0.7	1.9	2.8	-1.6	-0.4	-1.5	-1.3	-1.6	-1.2	-0.2	-1.5	-1.6	-1.4	-1.5	-1.7
Hearing difficulty/problems with background noise	0.7	1.1	2.4	-1.2	-0.6	-1.0	-1.4	0.7	-0.9	0.6	-0.5	-1.1	-1.5	-1.2	-1.1
Mouth/teeth dental problems	0.7	1.0	5.8	0.3	0.9	0.6	-1.1	0.8	-2.4	1.5	0.8	-0.2	-0.5	0.2	0.1
Medication: Ramipril	0.7	0.9	4.2	-0.2	0.0	-0.5	1.7	-0.9	2.1	1.1	-0.2	-0.4	0.6	-0.2	0.6
Depression (self-reported)	0.7	0.8	4.5	-0.1	-0.5	0.3	0.5	2.1	-1.5	-0.9	0.6	0.4	-0.7	-0.2	-0.9
Birth weight	0.7	1.5	10.9	-0.3	0.3	-0.5	0.7	-3.3	1.0	1.9	-1.0	-0.9	0.5	-0.3	-0.2
Pulse wave peak to peak time	0.7	0.8	4.9	-0.7	0.1	-0.3	-0.3	0.6	-2.2	-0.6	0.6	-0.8	-1.2	-0.7	-0.2
Qualifications: College or University degree	0.7	2.3	7.4	1.0	2.1	1.4	1.2	2.0	-1.1	2.7	1.9	0.6	0.3	1.1	0.9
Arm fat mass (left)	0.7	2.9	4.9	-1.8	-1.9	-1.8	-1.4	-2.1	-0.5	-1.7	-2.2	-2.0	-1.3	-1.7	-1.5
Medication: Paracetamol	0.7	1.1	4.2	-0.9	-1.8	-0.9	0.2	0.1	-0.9	-2.1	-1.0	-0.8	-0.9	-0.8	-0.5
Alzheimer’s Disease (in mother)	0.6	0.7	3.7	-0.0	0.2	-0.1	1.2	1.9	1.2	-0.5	0.7	-0.3	0.2	0.0	1.1
Vitamin and mineral supplements	0.6	0.8	5.9	0.4	0.6	0.7	1.0	0.6	-0.6	2.4	0.9	0.0	-0.5	0.3	-0.0
Maternal smoking around birth	0.6	0.9	5.0	0.8	-0.1	0.7	0.9	-0.0	0.2	-2.2	-0.0	1.2	0.5	0.8	1.0
Body mass index (BMI)	0.6	2.5	6.0	-1.4	-1.8	-1.5	-1.1	-1.8	-0.4	-2.4	-2.2	-1.7	-1.1	-1.4	-1.3
Number of live births	0.6	0.9	1.7	1.2	0.3	1.1	0.7	0.6	1.3	-0.3	0.5	1.3	1.2	1.2	0.4
Medication: Paracetamol	0.6	1.0	3.9	-0.9	-1.6	-1.0	0.6	0.1	-0.6	-2.0	-0.8	-0.9	-0.7	-1.0	-0.4
Medication: Allopurinol	0.6	0.8	2.5	-0.8	-0.7	-0.6	-0.8	-0.0	-1.4	-0.6	-0.9	-0.4	-0.9	-0.7	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	-0.7	-1.4	-0.9	-0.4	-0.5	1.3	-1.3	-0.9	-0.7	-0.3	-0.7	-0.3
Loneliness, isolation	0.6	0.8	3.5	-0.1	0.4	0.4	-0.4	1.3	-1.9	1.6	0.2	-0.5	-1.2	-0.1	-0.6
Osteoporosis (self-reported)	0.6	0.7	1.3	-1.0	-0.7	-1.0	-0.9	-0.1	-1.1	0.0	-0.8	-0.7	-1.0	-1.0	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.8	1.7	1.2	0.4	1.3	1.2	0.4	-0.2	0.8	1.0	1.1	0.4	1.1	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.6	5.9	0.2	0.3	0.1	-0.5	-0.7	0.6	2.4	0.4	0.0	0.5	0.2	0.4
Medication: Bendroflumethiazide	0.6	0.9	1.9	0.9	-0.2	0.8	0.9	1.3	1.1	-0.5	1.0	1.4	0.8	0.8	1.0
Risk taking	0.6	0.8	1.8	-0.7	-0.6	-0.6	-1.0	0.1	-1.3	-1.1	-0.6	-1.3	-1.3	-0.7	-0.2
Myopia	0.6	0.9	5.2	0.5	0.5	0.1	0.6	-1.3	2.3	0.6	0.1	-0.3	1.2	0.6	0.7
Cholesterol lowering medication	0.6	0.9	3.0	-0.6	-0.8	-0.4	-1.1	-1.4	-1.7	-0.1	-1.2	-0.6	-1.1	-0.6	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	-1.2	-0.9	-1.1	0.6	-0.8	-0.8	-0.6	-0.5	-0.9	-1.0	-1.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.1	-0.8	-0.6	-0.7	-1.1	-0.2	-1.0	-1.4	-0.6	-0.6	-0.9	-0.8	-0.8
Alcohol drinker status: Previous	0.6	0.7	1.9	-0.8	-0.7	-0.9	-1.4	-0.8	0.3	-0.7	-1.0	-1.3	-0.4	-0.7	0.3
Mean Putamen Volume	0.5	0.5	3.2	0.2	-0.1	-0.1	1.0	-0.5	1.8	0.0	0.2	0.5	0.8	0.1	0.9
Neuroticism (2016)	0.5	0.7	2.2	0.5	1.1	0.9	-0.1	1.5	-0.5	1.4	0.7	0.5	0.1	0.6	0.2
Height	0.5	10.5	68.6	2.5	4.5	3.0	-0.4	-1.5	1.0	8.3	2.5	1.4	1.8	2.5	0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	4.1	-0.7	-1.4	-0.8	0.0	-0.8	-0.3	-2.0	-0.9	-0.9	-0.6	-0.8	-0.3
Neuroticism	0.5	1.3	5.3	0.6	1.1	1.1	-1.0	2.0	-1.2	2.3	0.7	0.0	-0.5	0.6	0.1
Sensitivity / hurt feelings	0.5	0.9	1.8	1.1	1.2	1.4	0.1	0.9	-0.1	1.3	0.6	0.9	0.9	1.1	-0.2
Systolic blood pressure, automated reading	0.5	1.5	9.1	-1.0	-1.3	-1.3	0.0	-0.8	0.1	-3.0	-1.3	-0.6	-0.8	-1.0	-0.7
Medication: Metformin	0.5	0.7	2.1	-0.6	-1.0	-0.6	0.1	-1.1	-1.5	-1.2	-0.7	-0.8	-0.6	-0.7	-0.7
Qualifications: CSEs or equivalent	0.5	0.7	1.8	1.2	1.0	1.3	-0.6	0.8	-0.3	-0.6	0.3	1.0	0.4	1.1	0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	0.6	0.2	0.4	0.2	1.3	0.6	-0.5	0.8	0.9	0.6	0.6	1.4
Heart attack	0.5	0.6	1.0	-1.0	-0.7	-1.0	0.9	-0.9	-0.6	-0.7	-0.4	-0.6	-0.7	-1.0	-0.7
Prospective memory result	0.5	0.6	1.3	1.1	1.1	1.0	0.3	-0.1	0.2	0.2	0.3	0.9	0.8	1.1	0.9
Pulse wave reflection index	0.5	0.6	3.8	0.3	-0.2	-0.0	0.2	-1.5	1.9	-0.2	-0.5	0.2	0.9	0.3	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.1	0.2	1.1	0.5	1.0	-0.8	-1.4	0.3	1.2	0.7	1.1	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.1	0.8	1.3	0.8	-0.2	-0.2	0.5	1.8	1.1	0.8	0.7	0.8	0.8
Overall health rating	0.5	1.2	2.8	-0.8	-1.3	-0.6	-0.4	-0.9	-1.5	-0.3	-1.2	-0.9	-1.4	-0.8	-1.7
Average weekly champagne plus white wine intake	0.5	0.7	2.8	0.8	1.0	0.8	-0.7	0.0	0.9	1.7	0.6	0.5	0.5	0.8	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	-0.7	-0.2	-0.2	-0.9	0.6	-1.2	0.7	-0.6	-1.1	-1.3	-0.8	-1.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	5.3	0.1	1.0	0.3	-1.0	0.1	-1.6	2.3	0.4	-0.5	-0.3	0.1	-0.3
Age at First Birth	0.4	0.5	1.9	0.5	1.4	0.5	-1.1	0.8	0.0	0.9	0.6	0.4	0.1	0.6	0.4
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.7	-0.3	-0.8	-0.1	-0.9	0.5	-0.1	-0.9	-0.9	-0.3	-0.6	-0.4
Primary Biliary Cirrhosis	0.4	0.5	2.7	-0.1	0.3	-0.3	-0.1	-1.6	0.8	0.9	-1.0	-0.5	0.3	-0.1	-1.0
Rheumatoid Arthritis	0.4	0.5	2.0	0.8	0.3	0.6	0.2	-0.6	1.4	0.3	-0.5	0.6	1.2	0.8	0.3
Lung FVC	0.4	1.8	7.8	1.0	0.8	0.9	0.6	-0.7	2.8	0.6	1.8	0.8	1.7	1.1	1.4
Taking other prescription medications	0.4	0.7	2.2	-0.6	-1.5	-0.4	0.1	-0.2	-1.0	-1.1	-0.8	-0.7	-0.7	-0.6	-1.1
Had menopause	0.4	0.5	1.4	0.2	0.3	0.3	1.0	1.0	-1.1	0.9	1.2	0.4	0.1	0.3	0.3
Illnesses of siblings	0.4	0.5	4.2	-0.1	0.2	0.2	-0.5	-0.1	-2.1	0.6	0.3	-0.2	-0.6	-0.1	-0.8
Medication: Lansoprazole	0.4	0.4	1.5	-0.6	-0.3	-0.4	0.3	-0.2	-1.2	1.0	-0.2	-0.9	-0.6	-0.5	-0.7
Lung cancer (father)	0.4	0.5	1.9	-0.1	-1.1	0.1	1.0	0.2	-1.1	-1.4	0.0	0.4	-0.5	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.9	-0.4	-0.5	-0.6	0.2	-1.7	1.0	0.3	-0.2	0.0	0.3	-0.4	-0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	3.2	0.3	-0.3	0.2	1.3	0.3	1.8	0.1	0.3	1.0	0.4	0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.2	0.7	-0.0	0.7	0.7	0.3	0.9	-0.7	-0.0	1.1	0.6	0.7	0.1
Medication: Blood pressure	0.4	0.8	3.1	0.4	-0.7	0.2	1.8	0.6	1.6	-1.0	0.2	0.7	0.8	0.4	0.7
Heart disease (mother)	0.4	0.4	1.6	-0.3	-0.1	-0.5	-0.5	-1.0	0.2	-1.3	-1.2	0.2	0.1	-0.3	-0.6
Comparative height size at age 10	0.4	2.0	4.8	-1.3	0.3	-1.1	-1.2	-1.5	-1.9	2.2	-1.2	-1.6	-1.3	-1.3	-1.0
Number of full sisters	0.4	0.5	2.1	0.5	-0.6	0.4	1.5	0.5	-0.1	-0.9	0.4	0.7	0.4	0.4	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	-0.5	-0.0	-0.5	-0.9	-1.5	-0.3	1.0	-0.2	-0.1	-0.5	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.2	0.9	1.5	0.9	0.2	0.4	0.0	1.0	0.8	1.1	0.8	0.9	0.8
Friendships satisfaction	0.4	0.5	4.4	0.2	0.8	0.3	-0.2	0.3	0.2	2.1	0.4	0.5	0.4	0.2	0.0
Asthma (self-reported)	0.4	0.8	4.9	-0.2	-0.7	0.2	-0.1	0.6	-2.2	-1.6	-0.3	-0.2	-0.9	-0.2	-0.6
Guilty feelings	0.4	0.6	1.9	0.6	1.1	1.0	-0.0	0.9	-1.1	1.4	0.5	0.1	-0.1	0.6	-0.3
Wears glasses or contact lenses	0.4	0.5	1.9	-0.3	-0.9	-0.5	-0.2	-1.4	0.5	-1.3	-0.5	-0.5	0.2	-0.3	0.1
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.9	-0.3	-0.8	-0.2	0.5	-0.9	-0.6	-0.3	-0.7	-1.0	-0.9	-0.4
Unable to work because of sickness or disability	0.4	0.5	2.8	-0.3	-0.9	-0.3	0.5	0.5	0.0	-1.7	-1.0	-0.1	-0.3	-0.3	-0.3
Commuting to job workplace: Cycle	0.4	0.4	1.1	0.5	0.7	0.5	0.9	0.6	-0.2	0.1	1.1	0.8	0.6	0.6	0.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	5.3	-0.5	0.4	-0.1	-1.1	-0.1	-2.3	1.8	-0.1	-0.8	-1.0	-0.4	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	-0.3	-0.4	-0.1	-0.1	0.9	-1.2	-0.4	-0.0	-0.0	-0.9	-0.4	-1.1
Worry (Nagel 2018)	0.3	0.6	1.9	0.6	0.5	0.7	0.3	1.4	0.5	1.3	0.9	0.8	0.5	0.6	0.4
Crohns Disease (2012)	0.3	0.4	1.8	0.4	1.4	0.7	-0.7	0.8	-0.3	0.7	0.6	0.2	-0.3	0.5	0.0
Lupus	0.3	0.5	1.6	0.3	1.1	0.2	0.3	1.2	-0.4	1.3	0.7	0.1	0.4	0.3	0.6
Blood Eosinophil Count	0.3	2.4	5.5	-1.6	-2.1	-1.3	-1.0	-1.0	-1.7	-1.0	-1.5	-1.3	-1.7	-1.6	-2.4
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.4	-0.7	-0.6	0.1	-1.0	0.7	-0.6	-0.7	-0.2	0.1	-0.4	0.3
Supplements: Zinc	0.3	0.4	2.3	-0.3	-0.7	-0.4	0.2	-1.5	0.4	-0.0	-0.7	-0.6	0.0	-0.4	-0.5
Diabetes (father)	0.3	0.3	1.5	-0.3	-0.5	-0.3	-0.4	-0.7	0.3	-1.2	-1.0	0.1	-0.1	-0.2	-0.4
Leg fat-free mass (left)	0.3	1.4	4.2	-0.9	0.1	-0.8	-1.6	-2.1	-0.5	0.8	-1.3	-1.9	-0.8	-0.9	-0.8
Medication: Atenolol	0.3	0.4	1.8	-0.0	0.5	-0.2	0.5	-0.9	0.9	1.4	0.2	-0.2	0.3	-0.0	0.3
Sitting height	0.3	2.2	18.3	0.6	2.1	0.9	-0.4	0.4	0.7	4.3	0.9	-0.3	0.3	0.6	0.8
Leg predicted mass (left)	0.3	1.4	4.3	-0.9	0.1	-0.8	-1.7	-2.1	-0.5	0.8	-1.3	-1.9	-0.7	-0.9	-0.7
Waist circumference	0.3	1.1	3.5	-0.7	-1.1	-0.8	-0.8	-1.4	-0.8	-1.4	-1.9	-0.7	-0.5	-0.7	-0.9
Forced vital capacity (FVC)	0.3	1.1	4.9	0.6	1.4	0.8	-0.8	-1.2	0.7	2.2	1.1	0.2	0.8	0.6	0.4
Neuroticism score	0.3	0.6	3.2	0.2	0.7	0.6	-0.7	1.8	-0.7	1.3	0.4	-0.2	-0.5	0.2	-0.2
Weight	0.3	1.5	3.5	-1.2	-0.8	-1.1	-1.2	-1.9	-0.5	-0.4	-1.8	-1.6	-1.0	-1.2	-1.3
Father’s age at death	0.3	0.4	1.3	-0.8	-0.5	-0.9	-1.1	-0.1	0.3	0.6	0.0	-0.8	-0.3	-0.8	-0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.9	0.1	-1.1	0.3	0.1	0.5	-1.4	-1.2	0.1	-0.1	-0.5	0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.6	0.7	1.4	0.7	-1.0	-0.7	1.9	0.9	0.9	0.4	1.1	0.7	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	4.5	0.6	1.0	0.4	-1.1	-0.5	0.1	2.1	0.4	0.3	0.6	0.6	0.9
Asthma	0.3	0.6	3.4	-0.1	-0.7	0.1	0.1	0.6	-1.8	-1.6	-0.1	-0.1	-0.7	-0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.7	0.5	0.8	0.9	0.6	0.6	0.1	0.7	0.4	0.2	0.7	0.3
Medication: Cholesterol lowering	0.3	0.4	1.2	-0.6	-0.8	-0.7	0.9	-1.1	0.9	-0.2	0.1	-0.8	0.1	-0.6	0.1
Blood clot in the leg (DVT)	0.3	0.4	2.0	-0.5	-0.4	-0.5	-0.8	0.1	-0.6	-1.4	-0.3	-0.3	-0.6	-0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	0.2	0.8	0.4	-1.2	-0.1	-1.1	1.2	0.1	0.2	-0.3	0.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.2	0.5	0.1	0.3	1.1	0.5	0.7	-0.3	0.5	0.5	0.6	0.4	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	2.1	-0.4	-0.6	-0.3	0.2	1.4	-0.4	-0.2	-0.6	-0.3	-0.5	-0.5	-0.5
Age at first live birth	0.3	0.5	3.3	0.4	0.7	0.4	-0.2	0.7	0.4	1.8	0.8	0.1	0.1	0.4	0.7
Medication: Ibuprofen	0.3	0.3	1.3	0.7	0.2	0.8	1.2	0.6	0.3	0.1	0.8	0.4	0.0	0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.5	-0.2	-0.7	-0.4	0.7	-1.2	-0.1	-1.2	-0.5	-0.6	0.1	-0.2	0.0
Suffer from ‘nerves’	0.3	0.5	2.2	-0.1	-0.5	-0.4	1.3	0.3	1.5	-0.6	-0.8	0.1	0.5	-0.1	0.1
Leg fat-free mass (right)	0.3	1.6	4.1	-0.9	0.3	-0.8	-1.8	-1.9	-0.8	1.1	-1.4	-2.0	-0.9	-0.9	-0.8
Qualifications: nursing, teaching	0.3	0.5	1.1	0.7	0.2	0.6	0.6	1.1	0.5	-0.2	0.9	0.6	0.7	0.7	0.9
Breast cancer (self-reported)	0.3	0.4	1.5	0.5	-0.1	0.4	0.0	0.7	1.2	0.7	0.8	0.3	0.2	0.4	0.7
Osteoarthritis (self-reported)	0.3	0.4	1.6	-0.3	-1.3	-0.4	-0.6	-1.1	-0.4	-0.4	-0.5	-0.3	-0.4	-0.3	-0.7
Leg predicted mass (right)	0.3	1.6	4.0	-0.9	0.4	-0.8	-1.8	-1.9	-0.8	1.2	-1.4	-2.0	-0.9	-0.9	-0.8
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.7	-0.3	-0.7	-0.3	0.1	-0.9	0.1	-0.6	-0.3	-0.9	-0.7	-1.0
Bipolar Disorder (2018)	0.2	0.4	1.5	0.4	0.7	0.3	1.2	-0.0	0.6	0.7	0.1	0.5	0.7	0.6	0.3
Alzheimer’s Disease (in father)	0.2	0.3	1.1	0.3	0.5	0.1	1.1	0.1	0.4	-0.8	0.4	0.4	0.6	0.3	0.4
LDL Cholesterol	0.2	0.3	2.1	0.3	0.4	0.3	0.3	-1.4	-0.1	0.6	0.3	0.5	0.9	0.2	0.1
Systolic Blood Pressure	0.2	0.9	6.8	0.0	-0.4	-0.3	0.1	0.1	1.6	-2.6	-0.3	0.5	0.3	0.0	0.5
Chronotype (morning person)	0.2	0.5	2.0	0.4	0.8	0.5	-1.4	0.4	-1.4	1.0	-0.2	0.3	-0.3	0.4	0.1
Relative age of first facial hair	0.2	0.4	1.1	0.7	0.5	0.8	0.1	0.9	0.6	0.3	1.0	0.9	0.5	0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	0.4	0.3	0.5	-0.2	-0.7	-0.6	0.9	-0.0	0.2	-0.1	0.4	-0.0
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.2	-0.8	-0.2	0.6	-0.8	-0.1	-0.1	-0.3	-0.6	-0.3	-0.3	-0.3
Age when periods started (menarche)	0.2	0.5	1.9	-0.3	-0.9	-0.4	-0.5	0.2	1.4	-1.3	-0.1	-0.3	-0.2	-0.3	0.6
Number of incorrect matches in round	0.2	0.4	0.9	0.5	0.5	0.4	0.8	0.9	0.4	0.8	0.1	0.9	0.6	0.5	0.2
Had other major operations	0.2	0.2	0.8	-0.4	-0.8	-0.5	-0.9	-0.4	0.1	0.2	-0.6	-0.3	-0.2	-0.4	-0.3
Pain all over the body in last month	0.2	0.2	1.1	0.1	0.0	0.1	1.1	0.8	0.3	-0.2	0.1	0.3	-0.1	0.1	0.1
Fluid intelligence score	0.2	0.4	2.1	-0.2	0.4	-0.0	-0.3	0.2	-1.4	1.5	0.6	0.0	-0.2	-0.1	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	2.3	0.0	-0.9	-0.0	-0.3	-0.6	0.7	-1.5	-0.4	-0.0	0.3	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.1	-0.0	1.2	0.0	-1.3	-0.7	1.4	1.2	0.4	0.1	0.6	0.0	0.2
Standing height	0.2	2.0	17.1	0.5	2.1	0.8	-0.3	-0.6	-0.2	4.1	0.7	0.0	0.2	0.5	0.0
Length of working week for main job	0.2	0.2	0.8	0.3	0.2	0.3	-0.2	-0.9	0.5	-0.3	0.4	0.5	0.5	0.3	0.0
Hair/balding pattern: Pattern 4	0.2	0.6	3.4	-0.2	-0.1	-0.3	0.8	1.8	0.5	-1.4	-0.2	-0.2	-0.3	-0.2	0.3
Peak expiratory flow (PEF)	0.2	0.6	1.1	0.5	0.9	0.3	-0.9	-0.7	1.1	-1.1	0.1	0.4	1.0	0.5	0.7
Headache pain in last month	0.2	0.4	2.1	-0.2	-0.4	0.1	-0.4	-0.2	-1.4	-1.2	-0.2	-0.1	-0.5	-0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.9	5.2	0.1	1.2	0.3	-0.9	-1.3	0.8	2.3	0.8	-0.0	0.6	0.2	0.2
Arm fat-free mass (right)	0.2	0.9	2.8	-0.8	0.1	-0.7	-1.0	-1.7	-0.4	0.3	-1.2	-1.4	-0.6	-0.8	-0.9
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.3	-0.5	-0.4	0.4	-0.7	0.7	-0.8	-0.1	-0.5	0.2	-0.3	0.0
Health satisfaction	0.2	0.2	0.8	-0.3	0.0	-0.2	-0.9	-0.4	-0.8	-0.8	-0.4	-0.7	-0.2	-0.2	0.1
Arm predicted mass (right)	0.2	0.8	2.6	-0.7	0.4	-0.5	-1.0	-1.6	-0.6	0.8	-1.1	-1.3	-0.5	-0.7	-0.9
Alcohol intake frequency.	0.2	0.5	3.2	0.2	-0.1	0.4	-0.6	-0.4	-1.8	-1.0	-0.0	-0.3	-0.4	0.2	0.7
Medication: Aspirin	0.2	0.3	1.1	-0.5	-0.5	-0.6	0.2	-0.7	-0.2	-0.5	-1.1	-0.7	-0.1	-0.5	-0.5
Supplements: Vitamin C	0.2	0.2	0.9	0.5	0.5	0.5	-0.1	0.6	-0.1	-0.0	0.4	1.0	0.3	0.5	0.1
Illnesses of father: Heart disease	0.2	0.3	2.0	-0.4	-0.1	-0.4	-0.6	-1.4	0.2	0.1	-0.3	-0.7	0.3	-0.4	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.2	-0.2	0.1	0.6	-0.6	0.9	-0.6	-0.2	0.3	0.2	0.2	0.1
Whole body fat-free mass	0.2	1.0	3.7	-0.6	0.6	-0.5	-1.2	-1.9	-0.4	1.0	-1.0	-1.5	-0.5	-0.6	-0.7
Average weekly red wine intake	0.2	0.3	2.4	-0.3	-0.1	-0.6	0.1	0.0	1.5	0.1	0.1	-0.5	0.2	-0.3	0.2
Medication for cholesterol	0.2	0.2	1.8	0.0	0.5	-0.0	0.4	1.4	0.4	-0.2	0.4	0.1	0.2	0.0	0.4
Medication: Aspirin	0.2	0.3	1.0	-0.4	-0.5	-0.6	0.5	-1.0	0.0	-0.5	-0.9	-0.5	0.0	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	2.2	-0.4	0.2	-0.4	-1.5	-0.6	0.8	0.2	-0.3	-0.5	0.0	-0.3	-0.1
Whole body water mass	0.2	0.9	3.7	-0.6	0.6	-0.4	-1.2	-1.9	-0.4	1.0	-0.9	-1.5	-0.5	-0.6	-0.7
Miserableness	0.2	0.4	2.7	-0.1	0.5	0.2	-0.2	1.6	-0.4	0.6	0.2	-0.5	-0.7	-0.1	0.1
Hearing aid user	0.2	0.3	0.9	0.5	0.7	0.3	0.3	0.2	0.4	0.2	0.4	0.5	0.8	0.5	0.9
Medication: Blood pressure	0.2	0.4	2.2	0.3	-0.0	0.7	-0.4	-0.5	-1.5	0.8	0.2	0.0	-0.3	0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.8	0.6	0.8	-0.8	0.4	-0.0	-0.1	-0.1	0.3	0.4	0.8	0.5
Illnesses of father: High blood pressure	0.2	0.2	1.8	-0.0	0.1	-0.0	-1.3	0.8	-0.0	-0.6	-0.2	-0.0	-0.3	0.0	0.2
Basal metabolic rate	0.2	1.2	4.0	-0.9	0.2	-0.7	-1.4	-2.0	-0.6	0.6	-1.3	-1.6	-0.7	-0.8	-1.0
Fractured/broken bones in last 5 years	0.2	0.2	1.2	0.3	0.1	0.1	-0.0	1.1	-0.1	0.3	0.3	0.3	0.4	0.4	1.0
Diastolic blood pressure, automated reading	0.2	0.5	1.4	0.8	0.1	0.8	0.9	0.8	0.4	-0.2	0.6	1.2	0.5	0.9	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	0.3	1.2	0.1	-0.2	-0.7	1.1	0.8	0.6	0.1	1.0	0.3	0.8
Supplements: Calcium	0.2	0.2	0.8	-0.3	-0.9	-0.4	-0.6	0.3	0.5	-0.2	-0.3	-0.0	-0.2	-0.3	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	1.5	0.5	0.2	0.3	1.2	0.7	0.6	-0.3	0.4	0.7	0.4	0.5	0.4
Depression (Nagel 2018)	0.1	0.1	0.5	-0.0	-0.0	-0.0	0.1	0.7	0.1	0.4	0.0	0.0	-0.4	-0.0	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	2.2	-0.1	0.1	0.3	-0.5	0.8	-0.3	1.5	0.1	-0.1	-0.3	-0.1	-0.5
Schizophrenia (2018)	0.1	0.3	1.1	0.2	-0.3	0.2	0.7	1.0	0.2	-1.0	0.4	0.4	-0.1	0.2	0.4
Major Depression (MDD)	0.1	0.1	0.4	0.1	-0.3	0.0	-0.6	-0.3	-0.2	-0.4	-0.3	-0.2	-0.1	-0.0	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	1.2	-0.4	-0.1	-0.5	-0.2	-0.0	0.3	-1.1	-0.6	-0.4	-0.2	-0.3	-0.2
HDL Cholesterol	0.1	0.2	1.4	-0.3	-0.5	-0.5	0.5	0.4	0.1	-1.2	-0.1	0.2	-0.0	-0.2	0.1
Triglycerides	0.1	0.2	0.4	0.4	0.5	0.5	-0.7	-0.5	-0.1	-0.1	0.5	0.1	0.5	0.3	-0.1
Blood White Count	0.1	1.0	3.3	1.4	0.1	1.8	1.1	1.1	0.4	0.9	0.2	1.0	0.2	1.5	0.0
Heel T-Score	0.1	0.8	3.9	-0.1	0.3	-0.4	-0.9	-2.0	-0.1	-0.5	0.3	-0.8	0.8	-0.0	1.6
Cardiovascular Disease	0.1	0.3	2.2	-0.0	-0.8	0.2	-0.1	0.5	-0.2	-1.5	-0.4	-0.0	-0.4	-0.1	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.1	-0.4	-0.1	0.3	0.5	0.4	-0.4	-0.3	-0.1	-0.1	-0.1	0.0
Impedance of leg (right)	0.1	0.6	3.1	0.2	-0.9	0.1	0.8	1.3	0.3	-0.6	0.5	1.8	0.3	0.2	-0.2
Hand grip strength (right)	0.1	0.2	0.7	-0.4	0.6	-0.4	-0.8	-0.8	-0.1	0.6	-0.2	-0.5	-0.0	-0.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	1.4	0.0	-0.2	0.0	-0.0	1.2	0.4	-0.5	-0.1	-0.0	-0.2	0.1	0.2
High blood pressure	0.1	0.3	0.8	0.2	-0.9	0.4	0.4	0.7	-0.8	-0.8	-0.1	0.3	-0.6	0.2	-0.4
Impedance of leg (left)	0.1	0.6	1.7	-0.3	-1.2	-0.3	0.1	1.3	-0.4	-0.7	-0.1	1.3	-0.5	-0.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.3	0.0	-0.4	0.6	-0.4	0.5	-0.2	-0.1	-0.3	-0.1	-0.4	0.0
Qualifications: None of the above	0.1	0.2	0.6	-0.3	-0.7	-0.4	0.8	-0.3	0.1	-0.4	-0.7	0.2	-0.2	-0.3	-0.6
Impedance of arm (right)	0.1	0.4	1.3	-0.7	-1.1	-0.6	-0.5	0.2	-0.5	0.7	-0.1	-0.1	-0.8	-0.7	-0.6
Trunk fat-free mass	0.1	0.6	2.8	-0.3	0.9	-0.2	-0.8	-1.7	-0.3	1.1	-0.6	-1.1	-0.3	-0.3	-0.6
Worrier / anxious feelings	0.1	0.3	1.4	0.4	0.1	0.7	0.0	1.2	-0.5	0.0	0.8	0.3	0.0	0.4	0.2
Trunk predicted mass	0.1	0.6	2.9	-0.2	0.9	-0.1	-0.8	-1.7	-0.2	1.2	-0.5	-1.0	-0.2	-0.2	-0.5
Tense / ‘highly strung’	0.1	0.2	0.5	0.4	0.6	0.5	-0.3	0.7	0.4	0.6	0.6	0.1	0.4	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.0	-0.3	-0.4	-0.1	0.5	1.0	-0.2	0.2	0.3	0.1	-0.4	-0.3	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.9	-0.0	0.7	-0.1	-0.9	-0.3	-0.1	0.9	0.0	-0.2	0.2	0.0	0.3
Hypertension (Self-reported)	0.1	0.2	0.7	0.3	-0.8	0.4	0.6	0.5	-0.4	-0.9	-0.0	0.4	-0.2	0.3	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.6	0.3	-0.1	0.2	0.6	0.3	-0.2	-0.4	0.5	0.1	0.8	0.3	0.6
Medication: Gliclazide	0.1	0.1	0.4	-0.1	-0.4	-0.2	0.0	-0.3	0.6	-0.4	-0.2	-0.2	0.0	-0.2	0.2
Arm fat-free mass (left)	0.1	0.5	1.6	-0.3	0.8	-0.1	-0.8	-1.3	-0.4	1.1	-0.6	-0.9	-0.3	-0.2	-0.7
Average weekly beer plus cider intake	0.1	0.1	0.8	-0.0	0.0	-0.1	0.9	-0.1	0.4	-0.2	0.2	0.1	0.2	-0.1	0.0
Impedance of whole body	0.1	0.3	1.1	-0.3	-1.1	-0.3	0.1	1.0	-0.4	0.2	0.0	0.7	-0.5	-0.4	-0.6
Arm predicted mass (left)	0.1	0.7	2.5	-0.5	0.4	-0.4	-1.0	-1.6	-0.5	0.7	-0.9	-1.2	-0.5	-0.5	-0.8
Hair Pigment	0.0	0.9	4.4	0.5	0.5	0.8	1.0	2.1	0.5	0.7	1.6	1.1	-0.0	0.5	0.0
Tanning	0.0	0.4	2.0	0.2	0.4	0.1	-0.2	0.9	0.9	-1.4	-0.4	-0.1	0.3	0.2	0.4
Fed-up feelings	0.0	0.1	0.4	-0.0	0.0	0.1	-0.1	0.3	0.2	0.6	-0.1	-0.3	-0.2	-0.0	-0.2
Impedance of arm (left)	0.0	0.2	1.1	-0.5	-1.1	-0.5	-0.0	0.2	-0.3	0.6	-0.1	-0.0	-0.5	-0.5	-0.2

Hub : Genes

EIF2B3

Models

Trait associations