TWAS hub - MMACHC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0850	0.0430	1.0e-04	0.031	NA	0.056	NA	0.059	1.3e-03	NA	2.3e-05	NA	1.4e-05
2	GTEx	Cells Transformed fibroblasts	0.0950	0.0470	1.3e-04	0.041	NA	0.061	NA	0.079	4.4e-04	NA	2.3e-05	NA	1.5e-06
3	GTEx	Heart Atrial Appendage	0.1020	0.0430	4.3e-05	0.055	NA	0.099	NA	0.082	1.8e-03	NA	3.3e-05	NA	1.5e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0386	0.0179	1.2e-04	0.015	0.019	0.001	0.018	0.007	4.7e-03	1.4e-03	1.9e-01	0.002	4.2e-02
5	TCGA	Breast Invasive Carcinoma	0.0125	0.0095	4.8e-03	0.001	0.009	0.003	NA	0.004	2.0e-01	5.4e-03	6.4e-02	NA	3.6e-02
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1050	0.0560	1.9e-05	0.106	0.104	0.103	NA	0.111	1.2e-06	1.4e-06	1.7e-06	NA	6.6e-07
7	TCGA	Brain Lower Grade Glioma	0.0595	0.0352	2.0e-06	0.022	0.048	0.049	NA	0.046	1.4e-03	3.5e-06	2.7e-06	NA	5.8e-06
8	TCGA	Lung Adenocarcinoma	0.0407	0.0272	1.8e-03	0.027	0.028	0.021	NA	0.025	3.8e-04	3.0e-04	1.5e-03	NA	5.1e-04
9	TCGA	Lung Squamous Cell Carcinoma	0.0602	0.0473	1.5e-04	0.018	0.025	0.036	NA	0.021	3.4e-03	6.8e-04	5.5e-05	NA	1.7e-03
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.0670	0.0520	6.5e-04	0.017	0.030	0.026	NA	0.012	2.4e-02	4.2e-03	6.6e-03	NA	4.9e-02
11	TCGA	Pheochromocytoma and Paraganglioma	0.1610	0.0700	2.7e-05	0.120	0.118	0.103	NA	0.098	1.8e-05	2.1e-05	6.8e-05	NA	1.0e-04
12	TCGA	Prostate Adenocarcinoma	0.0748	0.0390	3.9e-08	0.049	0.080	0.085	NA	0.082	7.5e-06	9.1e-09	3.1e-09	NA	6.1e-09
13	TCGA	Thyroid Carcinoma	0.0940	0.0520	6.9e-07	0.053	0.058	0.045	NA	0.019	6.9e-06	2.5e-06	3.4e-05	NA	5.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Blood Platelet Count	13.2	153.0	342.2	-11.5	-13.7	-17.8	-17.0	-7.0	-12.1	-11.2	-11.1	-3.9	-5.3	-18.5	-7.5	-13.3
Blood Red Count	10.3	99.5	201.6	3.9	0.8	12.0	14.2	11.5	10.2	-1.3	11.8	7.0	9.9	10.1	12.2	12.6
Hearing difficulty/problems: Yes	7.1	10.8	22.8	2.4	2.2	4.6	4.8	3.1	3.3	1.5	3.1	2.1	2.5	4.0	3.7	3.6
Lung FEV1/FVC ratio	7.0	35.4	65.4	0.6	-0.9	-5.8	-7.6	-7.0	-7.7	0.5	-7.5	-3.7	-5.6	-6.9	-6.7	-8.1
Vitamin and mineral supplements	6.2	8.5	16.3	-1.6	-1.7	0.7	3.2	3.8	3.4	-2.5	3.2	3.2	4.0	1.3	3.4	3.3
Supplements: Glucosamine	6.0	7.8	14.3	-0.2	-0.3	-2.8	-3.8	-3.3	-3.4	0.4	-3.0	-2.6	-2.9	-2.8	-3.4	-3.6
Supplements: Fish oil (including cod liver oil)	5.3	6.9	16.5	-0.4	-0.8	-2.4	-4.1	-2.8	-3.4	0.3	-2.8	-2.5	-3.0	-2.6	-2.1	-3.5
Multivitamins +/- minerals	4.9	6.2	10.9	0.9	1.4	-1.1	-3.1	-3.3	-2.6	2.1	-2.9	-2.6	-3.3	-1.1	-3.2	-2.8
Had major operations	4.8	5.6	12.8	-2.1	-2.1	-3.6	-3.5	-1.6	-2.2	-1.8	-2.2	-1.0	-1.1	-3.5	-1.8	-2.5
Breast Cancer	4.6	11.2	29.1	3.0	3.8	5.4	4.5	2.1	3.6	2.9	1.8	0.7	1.4	4.8	2.3	3.7
Mineral and other dietary supplements	4.1	5.5	16.6	0.6	1.6	2.4	4.1	2.1	2.9	0.5	2.2	2.1	2.2	2.6	1.5	3.1
Systolic blood pressure, automated reading	3.9	11.3	23.2	-0.6	-0.5	-2.9	-4.8	-3.9	-3.9	0.5	-4.3	-2.8	-3.7	-3.5	-3.4	-4.5
Ever smoked	3.9	6.9	17.6	-2.4	-2.4	-4.2	-3.3	-2.1	-2.4	-2.0	-2.2	-0.6	-1.0	-3.9	-2.6	-2.5
Number of operations (self-reported)	3.9	5.8	14.2	-2.6	-2.4	-3.8	-2.6	-1.5	-2.6	-2.2	-1.9	-0.6	-1.1	-3.8	-1.5	-2.5
Qualifications: College or University degree	3.7	11.6	25.4	3.3	3.2	5.0	4.5	2.4	3.4	2.2	2.8	1.9	2.1	4.7	2.4	4.2
Current tobacco smoking	3.6	5.9	13.1	-1.9	-2.0	-3.4	-3.6	-1.9	-2.7	-1.4	-2.3	-1.2	-1.8	-3.3	-1.7	-2.8
Fasting Glucose	3.5	4.2	9.1	-0.5	-1.4	-1.5	-2.4	-2.3	-2.9	-0.9	-2.0	-1.0	-1.9	-3.0	-2.1	-2.8
Number of self-reported non-cancer illnesses	3.5	6.1	12.8	-1.3	-0.8	-3.1	-3.6	-2.4	-2.6	-0.5	-3.0	-2.0	-2.1	-3.1	-2.2	-3.2
Type 2 Diabetes (T2D) (2012)	3.4	3.9	8.0	-1.0	-1.3	-2.7	-2.4	-2.1	-2.4	-0.5	-1.9	-1.0	-1.6	-2.4	-2.8	-2.0
Smoking status: Current	3.4	5.4	10.8	-1.6	-1.8	-3.3	-3.3	-2.0	-2.7	-1.2	-2.3	-1.2	-1.9	-3.1	-1.9	-2.8
Exposure to tobacco smoke outside home	3.3	4.4	11.1	-2.1	-1.1	-3.3	-2.1	-2.2	-1.9	-0.7	-2.2	-0.3	-1.4	-2.9	-2.9	-2.1
Wears glasses or contact lenses	3.3	3.8	7.0	0.5	1.1	-1.2	-1.9	-2.6	-1.8	1.6	-2.3	-2.5	-2.4	-1.0	-2.6	-2.2
Smoking Status	3.0	7.1	19.6	-3.0	-2.8	-4.4	-3.6	-1.6	-2.0	-2.3	-2.3	-0.3	-1.0	-3.8	-2.1	-2.6
Birth weight of first child	3.0	5.5	11.1	-0.8	-1.3	1.3	2.8	3.0	2.9	-2.0	2.3	2.5	3.3	0.9	2.8	2.7
Ever had hysterectomy (womb removed)	2.8	3.2	7.9	-1.4	-1.7	-2.8	-2.3	-1.3	-2.1	-1.4	-1.4	-0.7	-1.1	-2.6	-1.2	-2.0
Mouth/teeth dental problems	2.8	4.3	10.1	1.1	1.6	3.2	2.4	1.8	2.9	1.3	1.0	0.8	1.1	3.0	2.1	2.5
Age started oral contraceptive pill	2.8	3.5	9.1	1.4	2.0	3.0	3.0	1.2	1.9	1.6	1.4	-0.3	0.8	2.5	1.3	2.0
Sitting height	2.7	18.9	40.6	1.5	-1.4	5.7	6.1	5.5	4.4	-2.2	3.6	2.4	5.0	2.7	6.4	5.2
Time employed in main current job	2.7	3.2	6.0	-0.5	-1.6	0.4	1.9	2.4	1.6	-1.7	2.1	2.0	2.4	0.5	2.3	1.7
Pulse rate, automated reading	2.7	8.7	30.1	-0.8	-2.0	2.0	2.0	4.6	3.1	-2.4	2.9	1.4	3.7	1.5	5.5	2.8
Tinnitus: Yes, now most or all of the time	2.7	3.2	5.6	-1.6	-0.1	0.9	2.2	2.2	2.2	-0.7	1.9	2.1	1.8	1.2	2.4	2.0
Alzheimer’s Disease (including proxy)	2.6	3.8	7.6	0.5	-0.1	-1.2	-2.6	-2.1	-2.3	0.6	-2.4	-2.8	-2.1	-1.4	-2.2	-2.4
Friendships satisfaction	2.6	3.2	8.2	2.8	2.9	2.8	2.0	-0.4	0.5	2.5	0.3	-0.1	-0.8	2.3	-0.7	0.7
Blood White Count	2.5	18.2	45.4	-4.2	-5.9	-1.7	3.1	4.7	2.5	-6.7	4.0	5.4	5.2	-1.5	3.0	3.6
Number of treatments/medications taken	2.5	4.5	12.2	-0.9	-0.5	-2.1	-3.5	-2.0	-1.8	0.2	-2.5	-3.2	-2.0	-1.9	-1.8	-2.6
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	5.7	0.9	2.0	-0.1	-2.4	-2.2	-1.1	2.1	-1.7	-1.5	-2.2	-0.0	-2.3	-1.3
Myopia	2.5	3.6	9.5	-2.5	-3.1	-3.0	-0.8	-0.2	-1.2	-2.9	0.1	1.3	0.3	-2.8	-0.7	-0.9
Systolic Blood Pressure	2.4	12.1	28.0	-1.4	-2.1	-3.4	-5.3	-3.1	-3.9	-1.2	-4.6	-2.6	-2.9	-4.5	-2.8	-4.6
Leg fat percentage (right)	2.4	8.6	25.9	-2.1	-2.1	-5.1	-3.8	-2.5	-3.1	-1.7	-1.8	-0.1	-1.4	-4.1	-3.3	-3.3
Commuting to job workplace: Walk	2.4	2.6	5.2	2.3	1.7	1.5	-1.0	-1.6	-0.8	2.1	-2.3	-2.0	-1.8	0.3	-1.3	-0.8
Verbal and Numeric Reasoning (VNR)	2.3	5.6	11.4	0.5	2.4	2.3	3.4	1.8	3.2	1.5	2.1	2.1	1.8	3.3	1.8	2.8
Severe depression (siblings)	2.3	2.6	11.1	2.3	0.9	1.4	-1.2	-1.1	-1.2	1.4	-1.8	-3.3	-1.7	-0.0	-0.3	-1.4
Mouth/teeth dental problems: Dentures	2.2	3.8	10.5	-2.0	-2.3	-3.2	-1.6	-1.1	-2.5	-2.0	-0.5	-0.3	-0.5	-3.1	-1.3	-1.8
Qualifications: A levels/AS levels or equivalent	2.1	4.7	9.8	0.5	1.4	2.8	2.5	1.9	2.8	0.9	1.8	1.8	1.7	3.0	2.0	3.1
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	8.9	-2.1	-2.3	-3.0	-1.7	-0.2	-1.0	-2.3	-0.1	0.9	0.4	-2.3	-0.9	-1.1
High blood pressure (siblings)	2.1	3.1	7.2	0.5	-1.1	-0.9	-2.7	-1.2	-2.1	-0.3	-2.3	-2.3	-1.4	-2.2	-0.5	-2.6
Comparative height size at age 10	2.1	11.4	22.1	1.7	1.2	4.5	4.7	3.6	3.7	0.4	3.5	1.4	3.0	3.7	4.6	4.1
Alzheimer’s Disease (in father)	2.0	2.2	5.2	-0.3	-0.6	-1.2	-2.1	-1.3	-1.3	-0.1	-2.0	-2.3	-1.3	-1.4	-1.3	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.9	2.2	2.2	1.4	-0.6	-1.4	-0.2	2.1	-1.9	-2.1	-1.2	0.5	-1.3	-0.6
Leg fat percentage (left)	2.0	7.3	23.3	-1.9	-1.9	-4.8	-3.4	-2.3	-2.9	-1.5	-1.5	-0.1	-1.3	-3.7	-3.0	-3.1
Length of working week for main job	1.9	2.1	5.6	-2.3	-2.1	-2.3	-0.8	0.6	0.0	-2.4	-0.1	0.9	0.8	-1.9	0.0	-0.2
Medication: Allopurinol	1.9	2.5	4.6	-1.7	-0.7	-0.3	1.3	2.0	1.9	-1.0	2.1	1.4	1.8	1.3	1.9	1.9
Loneliness, isolation	1.9	2.6	5.1	-1.2	-0.9	0.6	1.6	2.2	2.1	-1.2	1.6	1.5	1.9	0.9	2.1	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	4.8	0.4	1.2	1.6	1.3	1.6	2.2	0.8	1.0	0.6	1.1	2.0	1.8	1.9
Breast cancer (self-reported)	1.9	2.3	6.7	-1.8	-2.6	-2.4	-1.2	0.1	-1.1	-2.4	0.1	0.4	0.1	-2.0	-0.1	-1.1
Average weekly champagne plus white wine intake	1.9	2.5	7.3	0.8	1.1	1.7	2.7	1.3	1.5	0.3	1.7	1.8	1.3	1.9	1.1	2.1
Hearing aid user	1.9	2.1	7.8	1.5	2.8	1.9	1.2	-0.5	0.7	2.4	0.1	-0.6	-0.7	2.0	-0.5	0.9
Ulcerative Colitis	1.8	2.7	8.4	2.7	2.1	2.9	2.0	0.3	0.8	1.6	0.6	0.2	0.4	2.0	0.3	1.4
Taking other prescription medications	1.8	2.8	7.5	-1.7	-0.8	-2.7	-1.9	-1.7	-1.6	-0.4	-1.4	-0.9	-1.3	-2.0	-2.0	-1.9
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.2	-2.0	-1.8	-2.2	-0.7	-0.8	-2.0	-1.6	-0.3	0.3	-0.7	-2.3	-0.7	-1.2
Hair/balding pattern: Pattern 3	1.8	2.7	6.7	-2.6	-2.2	-2.6	-1.5	-0.7	-1.2	-2.2	-0.5	0.3	-0.1	-2.4	-1.4	-1.0
Pulse rate	1.8	3.1	8.7	0.1	-0.0	1.8	1.7	2.5	2.0	-0.6	1.7	0.6	1.8	1.8	2.9	2.2
Shortness of breath walking on level ground	1.8	2.1	4.5	2.1	1.8	2.1	2.1	0.5	0.9	1.5	1.3	0.0	0.5	2.0	0.4	1.4
Suffer from ‘nerves’	1.8	2.8	7.9	-2.1	-2.4	-2.8	-1.8	-0.2	-1.1	-2.1	-0.7	0.7	0.3	-2.4	-0.3	-1.4
Financial situation satisfaction	1.8	2.2	6.9	-1.9	-1.2	-2.6	-2.2	-0.8	-1.5	-1.1	-1.1	0.1	-0.7	-2.0	-0.6	-1.6
Supplements: Calcium	1.8	1.9	5.2	-0.7	-1.1	-1.0	-2.1	-0.9	-1.1	-0.6	-2.3	-1.5	-0.5	-2.2	-0.5	-1.7
Height	1.7	31.8	75.2	3.0	-0.1	8.0	8.7	6.4	6.2	-0.9	4.5	2.5	5.9	4.7	7.3	6.9
Average weekly spirits intake	1.7	2.2	7.0	1.0	1.0	-0.9	-1.1	-2.2	-1.8	1.1	-1.1	-0.5	-1.9	-0.8	-2.6	-1.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	3.2	0.2	0.3	1.3	1.8	1.5	1.5	0.0	1.7	1.1	1.2	1.7	1.6	1.8
Diabetes (mother)	1.7	2.2	5.8	-1.5	-1.0	-2.4	-1.9	-0.9	-0.8	-0.9	-1.7	-1.1	-0.6	-2.1	-1.5	-1.7
Comparative body size at age 10	1.7	4.6	10.0	0.0	0.2	-2.0	-3.2	-2.6	-2.7	0.6	-2.5	-1.6	-2.3	-2.0	-2.0	-3.0
Osteoarthritis (self-reported)	1.7	2.1	8.8	-2.3	-1.0	-3.0	-1.6	-0.9	-0.6	-1.0	-0.9	-0.6	-0.3	-1.9	-1.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.6	-0.2	0.3	-1.3	-1.2	-1.8	-1.7	0.8	-1.8	-1.9	-1.9	-1.1	-1.9	-1.7
Rheumatoid Arthritis	1.6	2.3	6.7	-2.6	-1.9	-2.4	-0.8	0.8	0.3	-2.2	0.4	1.8	1.2	-1.4	0.5	0.1
Maternal smoking around birth	1.6	2.3	8.0	-2.2	-1.1	-2.8	-2.4	-0.7	-0.7	-1.2	-0.8	-1.0	-0.5	-1.7	-1.2	-1.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	5.2	-2.3	-1.7	-2.2	-0.9	0.1	-0.5	-1.9	-0.5	0.2	0.3	-1.8	0.0	-0.6
Past tobacco smoking	1.6	3.0	9.5	2.0	1.6	3.1	2.2	1.2	1.0	1.5	1.3	-0.3	0.4	2.6	1.7	1.4
Had menopause	1.6	2.0	5.4	1.6	2.2	2.3	1.0	0.4	1.3	2.0	0.1	-1.2	0.1	1.9	0.9	0.8
Glaucoma (self-reported)	1.6	1.9	4.3	-2.0	-2.1	-2.1	-1.5	-0.2	-0.9	-1.9	-0.4	-0.2	0.1	-1.9	-0.1	-0.8
Migraine (self-reported)	1.6	2.0	3.9	-0.2	-1.3	-0.7	-1.3	-1.4	-1.8	-0.7	-1.7	-2.0	-1.3	-2.0	-1.4	-1.6
Back pain experienced in last month	1.6	2.4	5.0	0.5	0.9	-1.0	-1.3	-2.2	-1.8	1.2	-1.6	-1.2	-1.9	-0.8	-2.2	-2.0
Medication: Paracetamol	1.6	2.4	9.2	0.5	0.4	-0.8	-2.4	-1.3	-1.1	1.1	-1.8	-3.0	-1.6	-0.5	-1.0	-2.0
Supplements: Zinc	1.5	1.6	3.8	-1.6	-1.4	-1.9	-1.7	-0.3	-0.4	-1.3	-1.3	-0.7	0.1	-1.9	-0.4	-1.2
Number of live births	1.5	2.1	4.1	0.4	-0.5	-1.2	-1.8	-1.7	-1.9	0.1	-2.0	-0.8	-1.6	-1.5	-1.6	-1.7
Standing height	1.5	15.0	30.8	1.6	0.2	5.2	5.5	4.5	4.3	-0.6	3.4	2.0	4.0	3.4	5.3	4.8
Eye problems/disorders: Cataract	1.5	1.7	5.2	2.2	1.3	2.3	1.4	0.3	0.4	1.5	0.9	-1.3	-0.1	1.9	0.7	0.4
Eye problems/disorders: Glaucoma	1.5	1.7	4.9	-1.8	-1.2	-2.2	-1.7	-0.8	-1.2	-1.1	-0.9	-0.6	-0.5	-1.9	-0.7	-1.3
High cholesterol (Self-reported)	1.5	2.6	7.2	-2.7	-2.0	-2.7	-1.7	-0.4	-1.3	-1.8	-0.4	0.1	-0.0	-2.3	-0.3	-1.4
Body Mass Index (BMI) (2010)	1.4	1.9	4.2	-0.9	-0.3	-2.0	-1.6	-1.5	-1.4	-0.1	-1.3	-1.5	-1.2	-1.6	-1.6	-1.7
HDL Cholesterol	1.4	2.3	5.8	0.7	0.7	-0.7	-2.4	-2.0	-1.6	1.0	-1.9	-1.0	-1.9	-0.8	-1.7	-1.8
Fluid intelligence score	1.4	2.9	6.8	0.4	2.2	1.8	2.1	0.9	2.4	1.5	1.3	1.2	1.1	2.6	0.9	2.2
Lung cancer (father)	1.4	1.6	4.0	-1.4	-0.3	-2.0	-1.9	-1.1	-1.2	-0.4	-0.9	-0.9	-1.2	-1.4	-1.4	-1.4
Birth weight	1.4	3.1	6.0	-1.0	-1.0	0.4	1.9	2.2	1.6	-1.5	2.5	2.2	2.2	0.9	2.4	1.9
Worry too long after embarrassment	1.4	2.3	8.4	1.9	0.4	2.9	2.1	1.3	1.5	0.4	1.0	0.3	0.9	1.8	1.5	1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.5	-0.4	-1.1	-1.8	-1.8	-1.1	-1.9	-0.7	-0.8	-0.9	-0.8	-1.7	-1.3	-1.4
Ever had bowel cancer screening	1.4	1.6	4.6	-0.9	-1.6	0.1	0.6	1.5	0.6	-2.2	1.2	1.6	1.8	-0.7	1.3	1.0
Ever taken oral contraceptive pill	1.4	1.6	3.0	-1.1	-1.6	-0.2	-0.0	1.5	0.9	-1.7	1.3	1.6	1.5	0.0	1.4	1.3
Ulcerative Colitis (UC)	1.3	2.4	7.2	2.5	1.2	2.7	2.0	0.8	0.8	1.0	1.0	1.2	0.9	2.0	0.6	1.6
Prostate Cancer	1.3	1.9	7.2	-1.7	-2.7	-2.0	-0.5	0.3	-0.8	-2.3	0.5	1.0	0.6	-1.5	0.1	-0.3
Neuroticism (2016)	1.3	1.9	7.7	2.8	1.6	2.2	0.3	-0.8	-0.3	2.0	-0.8	-1.6	-0.5	1.0	0.0	-0.6
BMI	1.3	7.7	16.6	-0.1	-0.4	-4.0	-3.4	-3.5	-3.4	0.1	-2.4	-0.4	-2.2	-3.3	-4.1	-3.3
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.1	0.1	1.1	-0.6	-1.2	-1.7	-1.2	1.3	-1.2	-1.8	-1.7	-0.6	-1.5	-1.4
Body mass index (BMI)	1.3	5.6	12.9	-0.5	-0.6	-3.6	-3.1	-2.7	-2.8	-0.3	-2.0	-0.7	-1.8	-2.9	-3.1	-3.0
Hearing difficulty/problems with background noise	1.3	2.1	6.0	0.9	0.2	2.4	2.1	1.7	1.1	-0.0	1.2	0.4	1.1	1.2	2.2	1.6
Pulse wave reflection index	1.3	1.6	3.2	-0.4	-0.5	-1.2	-1.1	-1.5	-1.5	-0.2	-1.8	-0.8	-1.2	-1.6	-1.8	-1.3
Medication: Paracetamol	1.3	2.1	7.5	0.5	0.6	-0.8	-2.0	-1.4	-1.1	1.1	-1.9	-2.7	-1.6	-0.5	-1.1	-1.8
Number of children fathered	1.3	1.4	4.3	-1.1	-1.7	-1.4	-1.2	-0.5	-1.0	-1.5	-1.4	0.1	-0.2	-2.1	-0.7	-0.9
Emphysema/chronic bronchitis	1.3	1.4	2.9	-0.9	-0.8	-1.4	-1.4	-1.2	-1.4	-0.7	-1.2	-0.6	-1.2	-1.7	-1.4	-0.9
Medication for pain relief, constipation, heartburn	1.3	2.1	7.2	-0.6	-0.8	0.5	1.6	1.7	1.3	-1.1	1.7	2.7	1.6	0.7	1.5	1.7
Neck or shoulder pain in last month	1.3	1.8	3.9	-1.3	-1.4	-1.9	-1.9	-0.7	-1.1	-1.1	-1.2	-0.8	-0.5	-2.0	-0.7	-1.6
Medication: Omeprazole	1.3	1.6	3.8	-0.4	0.2	-1.4	-1.0	-1.6	-1.5	0.5	-1.2	-1.1	-1.6	-1.1	-2.0	-1.4
Overall health rating	1.3	2.9	9.0	-2.6	-2.7	-3.0	-0.9	0.3	-0.6	-2.4	-0.1	0.2	0.5	-2.4	0.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.6	-1.3	-1.3	-2.1	-1.6	-0.9	-1.2	-1.1	-1.1	0.7	-0.4	-1.7	-1.0	-1.1
Supplements: Vitamin C	1.3	1.6	3.0	0.4	0.7	-0.3	-1.2	-1.6	-1.5	1.1	-1.7	-1.2	-1.7	-0.7	-1.1	-1.7
Pain experienced in last month	1.3	2.2	4.4	0.5	0.4	2.1	2.1	1.7	1.6	0.1	1.3	0.9	1.1	1.7	2.0	1.8
Major Depression (MDD)	1.2	1.4	4.1	-0.4	0.5	-0.7	-0.9	-1.8	-1.0	0.9	-0.9	-1.4	-1.7	-0.4	-2.0	-1.2
Coronary Artery Disease (CAD)	1.2	1.4	3.3	0.5	-0.2	-1.3	-1.6	-1.6	-1.8	0.0	-0.8	0.4	-1.4	-1.1	-1.7	-1.2
Average weekly fortified wine intake	1.2	1.4	3.8	1.8	1.9	1.9	1.0	-0.3	0.3	1.6	-0.1	0.6	-0.3	1.3	-0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	9.8	2.2	3.1	1.8	0.6	-1.0	0.1	2.8	0.3	-1.0	-1.1	2.0	-1.0	0.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.8	-0.3	1.2	-0.8	-1.5	-1.7	-0.8	1.4	-1.4	-1.3	-1.4	-0.3	-1.7	-1.3
Impedance of arm (right)	1.2	5.8	10.8	-2.1	-1.5	0.9	2.2	3.3	2.9	-2.0	2.6	1.9	2.9	1.2	3.2	3.0
Impedance of arm (left)	1.2	5.7	14.3	-1.6	-1.2	1.6	2.0	3.4	3.0	-1.7	2.3	1.7	2.7	1.4	3.8	3.0
Medication: Blood pressure	1.2	2.2	6.1	-0.6	-1.9	-1.0	-2.3	-0.6	-1.4	-1.6	-1.7	-1.4	-0.4	-2.5	-0.6	-1.5
Heart disease (mother)	1.2	1.5	3.8	1.9	1.6	1.0	-0.3	-1.4	-0.9	1.8	-0.9	-1.1	-1.3	0.2	-1.3	-0.8
Intelligence (Savage-Jansen 2018)	1.1	3.4	8.0	1.2	2.8	2.2	2.5	0.7	2.1	2.1	1.2	1.1	0.8	2.8	1.0	1.7
Alzheimer’s Disease (in mother)	1.1	1.2	2.7	0.6	-0.2	-0.9	-1.4	-1.2	-1.6	0.2	-1.2	-1.2	-1.2	-0.9	-1.3	-1.3
Primary Biliary Cirrhosis	1.1	1.6	3.7	0.1	0.2	-1.0	-0.4	-1.9	-1.8	0.4	-1.2	-0.8	-1.7	-1.1	-1.9	-1.4
Chronotype (morning person)	1.1	2.4	5.6	0.5	1.7	1.6	1.5	1.4	2.2	1.0	1.5	0.5	1.3	2.4	1.2	2.3
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.9	0.8	2.0	1.2	2.0	0.4	1.4	1.6	1.1	1.0	0.3	2.2	0.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.4	-1.6	-1.3	-2.1	-1.8	-0.4	-0.3	-1.1	-0.7	0.2	-0.2	-1.3	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.6	-0.8	-0.7	0.3	0.7	1.5	1.1	-0.9	1.1	1.7	1.3	0.3	1.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.2	0.2	-0.2	1.8	1.7	2.0	1.8	-0.7	1.5	1.0	1.6	1.5	2.3	1.9
Average weekly red wine intake	1.1	1.6	3.7	-1.2	-1.6	-1.9	-1.3	-0.7	-1.4	-1.3	-0.9	-0.1	-0.7	-1.9	-1.0	-1.3
Osteoporosis (self-reported)	1.1	1.3	2.7	-1.1	-0.9	0.5	0.9	1.6	1.3	-1.0	1.2	1.2	1.4	0.5	1.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	3.9	0.1	-0.4	-1.3	-1.0	-1.8	-2.0	-0.2	-2.0	-1.2	-1.5	-1.9	-2.0	-2.0
Cardiovascular Disease	1.0	3.2	9.5	-1.5	-3.1	-1.6	-2.7	1.0	-0.6	-2.7	-1.0	0.0	1.0	-2.4	1.7	-0.9
Neuroticism	1.0	2.3	6.0	0.6	-0.2	2.0	2.0	2.1	1.7	-0.4	1.3	0.8	1.8	1.2	2.5	1.3
Qualifications: CSEs or equivalent	1.0	1.3	4.1	-1.0	-1.7	-2.0	-1.9	-0.2	-1.0	-1.2	-0.4	-0.2	0.0	-1.4	-0.4	-0.9
High blood pressure (mother)	1.0	1.4	6.5	-0.2	-1.2	-1.1	-2.5	-0.6	-1.2	-0.7	-0.9	-1.0	-0.5	-1.5	-0.1	-1.4
Arm fat percentage (right)	1.0	3.8	12.1	-1.3	-1.3	-3.5	-2.6	-1.6	-1.9	-1.2	-1.3	-0.2	-0.7	-2.9	-2.0	-2.1
Asthma	1.0	2.0	5.6	0.4	1.4	-1.0	-2.4	-1.6	-1.0	1.6	-1.4	-1.3	-1.6	-0.2	-1.4	-1.6
Illnesses of mother	1.0	1.2	5.6	-0.2	0.6	1.3	2.4	0.8	1.1	-0.0	1.0	1.2	0.7	1.1	0.6	1.4
Peak expiratory flow (PEF)	1.0	2.2	6.7	0.5	0.5	-1.0	-2.4	-1.8	-1.5	0.7	-2.6	-0.8	-1.5	-1.2	-1.3	-1.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	7.1	-1.4	-0.0	-2.4	-1.1	-1.9	-1.0	0.3	-1.2	-0.1	-1.0	-1.4	-2.7	-1.4
Leg fat mass (right)	1.0	4.0	11.1	-0.8	-1.2	-3.3	-2.5	-2.0	-2.3	-0.9	-1.4	-0.4	-1.1	-2.8	-2.4	-2.5
Chest pain or discomfort	1.0	1.5	4.5	-0.3	-0.8	-1.6	-2.1	-1.1	-1.3	-0.6	-1.1	-0.7	-0.8	-1.8	-0.9	-1.4
Hypothyroidism (self reported)	0.9	2.0	6.9	-1.9	-0.8	-2.6	-1.1	-1.4	-0.6	-0.6	-1.0	0.7	-0.2	-1.8	-2.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.1	-1.0	-1.1	-2.0	-1.5	-1.1	-1.4	-0.9	-0.9	0.1	-0.8	-1.9	-1.5	-1.1
Diabetes (father)	0.9	1.1	4.7	-1.2	-1.4	-2.2	-0.6	-0.1	-0.6	-1.4	0.5	1.2	0.4	-1.2	-0.8	-0.5
Relative age voice broke	0.9	1.3	3.1	-1.4	-1.5	-0.7	1.0	1.4	0.6	-1.8	1.2	0.9	1.5	-0.5	1.1	0.7
Financial difficulties in last 2 years	0.9	1.2	4.0	-1.3	-1.4	-2.0	-1.4	-0.1	-0.8	-1.2	-0.4	0.5	0.0	-1.5	0.2	-1.1
Body fat percentage	0.9	3.6	12.9	-1.4	-1.7	-3.6	-2.4	-1.3	-1.8	-1.5	-0.9	0.1	-0.4	-2.8	-1.7	-2.0
Wheeze or whistling in the chest in last year	0.9	1.6	7.3	-1.4	-0.2	-2.7	-2.7	-0.7	-0.6	-0.1	-0.8	0.2	-0.6	-0.9	-0.7	-1.1
Qualifications: nursing, teaching	0.9	1.4	5.5	2.4	1.5	2.0	0.1	-0.4	0.3	1.7	-0.3	-1.1	-0.4	1.3	-0.4	0.3
Medication: Bendroflumethiazide	0.9	1.4	4.7	0.5	-0.9	-0.1	-2.2	-0.7	-1.4	-0.3	-1.7	-1.2	-1.0	-1.3	-0.1	-1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.7	-0.6	-1.6	-1.2	-1.0	-0.6	-1.0	-1.3	-0.7	0.2	-0.1	-1.6	-1.2	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.0	2.8	-0.8	-1.7	-0.3	0.5	1.2	0.3	-1.6	1.1	1.1	1.2	-0.2	1.0	0.7
Age at First Birth	0.8	1.2	4.5	1.0	0.8	2.1	1.2	0.9	1.0	0.6	0.3	0.8	0.6	1.2	1.4	1.2
Heel T-Score	0.8	6.1	17.4	2.8	4.2	3.6	2.7	-0.1	1.2	3.6	1.3	-0.1	-0.5	3.7	0.3	1.8
Qualifications: None of the above	0.8	1.7	5.8	-2.4	-1.8	-2.2	-0.1	0.8	0.0	-1.8	0.7	1.2	0.8	-1.4	0.5	-0.5
Medication: Simvastatin	0.8	1.2	4.1	-2.0	-1.6	-1.5	-0.6	0.2	-0.1	-1.6	0.1	1.3	0.7	-1.3	0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.5	-1.5	-1.3	-1.9	-1.5	0.1	-0.3	-1.0	-0.6	-0.4	0.1	-1.3	0.0	-1.1
Age at first live birth	0.8	1.5	3.6	0.3	0.0	1.2	1.4	1.2	1.6	-0.3	1.2	1.4	1.5	1.0	0.9	1.9
Knee pain experienced in last month	0.8	1.2	3.1	-0.1	-0.2	-1.8	-1.3	-1.4	-1.6	-0.0	-0.2	-0.1	-0.9	-1.1	-1.5	-1.3
Hypertension (Self-reported)	0.8	2.3	7.1	-0.7	-1.8	-1.2	-2.7	-0.1	-1.1	-1.4	-1.9	-1.5	-0.1	-2.3	0.6	-1.7
Arm fat percentage (left)	0.8	3.3	10.0	-1.0	-1.1	-3.2	-2.6	-1.6	-1.9	-1.0	-1.4	-0.3	-0.8	-2.6	-1.7	-2.1
Asthma (self-reported)	0.8	1.7	4.9	0.3	1.3	-1.0	-2.2	-1.5	-0.9	1.4	-1.4	-1.1	-1.5	-0.2	-1.4	-1.5
Medication: Gliclazide	0.8	0.9	2.6	-0.3	-0.2	-0.8	-0.4	-1.3	-1.1	0.1	-1.0	-0.9	-1.1	-1.2	-1.6	-1.0
Guilty feelings	0.8	1.2	5.9	-0.1	-0.7	1.2	0.8	1.6	0.9	-0.7	0.9	0.8	1.1	0.6	2.4	0.7
Unable to work because of sickness or disability	0.8	1.0	3.3	-0.7	-0.6	-1.5	-1.8	-1.0	-1.0	-0.1	-1.0	-0.5	-1.0	-0.9	-0.9	-1.1
Impedance of whole body	0.8	4.1	7.8	-2.3	-1.5	0.3	1.5	2.8	2.4	-1.8	2.1	1.8	2.4	0.9	2.6	2.4
Leg fat mass (left)	0.8	3.2	9.8	-0.7	-1.1	-3.1	-2.2	-1.7	-2.1	-0.8	-1.1	-0.3	-0.8	-2.5	-2.0	-2.2
Bipolar Disorder (2011)	0.7	0.7	2.5	1.6	1.1	1.4	0.8	-0.7	-0.3	0.9	-0.6	-0.4	-0.7	0.4	-0.8	0.0
Blood Eosinophil Count	0.7	5.1	15.1	-3.9	-3.1	-2.4	0.7	1.8	1.0	-3.6	1.2	2.3	2.1	-1.4	1.0	1.5
Angina	0.7	0.9	2.7	-1.7	-1.3	-1.5	-0.4	0.4	-0.2	-1.4	0.9	0.9	0.6	-1.0	0.0	0.1
Age when periods started (menarche)	0.7	1.7	5.2	-2.0	-2.3	-1.4	-0.8	0.8	-0.2	-2.1	0.5	1.0	0.8	-1.4	1.0	-0.4
High blood pressure	0.7	2.1	5.7	-0.6	-1.8	-0.9	-2.4	0.1	-0.9	-1.5	-1.8	-1.3	0.0	-2.3	0.8	-1.6
Noisy workplace	0.7	0.8	1.7	0.3	0.2	-1.1	-0.7	-1.2	-1.2	0.5	-0.8	-0.1	-0.9	-0.7	-1.3	-1.3
Medication: Cholesterol lowering	0.7	1.0	3.5	-1.4	-1.9	-1.2	-0.4	0.4	-0.3	-1.8	0.4	0.7	0.7	-1.3	0.2	-0.2
Arm fat mass (right)	0.7	2.7	7.5	-0.5	-0.8	-2.7	-2.1	-1.7	-1.8	-0.6	-1.2	-0.2	-0.9	-2.4	-1.9	-2.0
Headache pain in last month	0.7	1.2	3.4	-0.6	-0.8	-0.8	-1.9	-0.7	-0.7	-0.4	-1.8	-1.4	-0.6	-1.6	-0.6	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	-0.7	0.1	-1.5	-1.5	-0.8	-0.5	0.4	-0.9	-1.6	-0.8	-0.5	-0.7	-1.2
Angina (self-reported)	0.7	1.0	2.8	-1.7	-1.3	-1.4	-0.2	0.5	-0.1	-1.4	1.1	1.1	0.7	-0.9	-0.0	0.3
Medication: Lisinopril	0.7	0.9	1.8	-0.5	-0.6	0.5	1.0	1.3	1.0	-0.8	1.3	0.4	1.2	0.5	1.4	1.1
Alcohol drinker status: Never	0.7	0.8	3.1	-0.0	1.0	0.7	0.7	0.4	0.7	0.5	1.7	0.8	0.1	1.5	0.2	1.1
Diastolic blood pressure, automated reading	0.7	2.1	7.7	-1.1	-1.5	-1.6	-2.8	-0.6	-1.1	-1.1	-1.8	-0.8	-0.5	-2.1	-0.3	-1.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.2	0.5	1.9	0.8	2.2	-0.1	1.0	1.5	1.8	1.2	-0.0	2.3	-0.8	1.6
Lupus	0.6	0.8	3.2	1.1	1.8	1.0	0.9	-0.3	0.4	1.5	0.4	-0.1	-0.4	1.3	-0.3	0.4
Pack years adult smoking proportion	0.6	0.9	2.4	-1.3	-1.5	-1.1	-0.8	0.8	-0.5	-1.4	0.7	0.4	0.5	-0.8	1.5	-0.4
Trunk fat percentage	0.6	2.3	8.9	-1.4	-1.7	-3.0	-1.8	-0.7	-1.2	-1.5	-0.5	0.3	0.0	-2.3	-1.0	-1.3
Medication: Levothyroxine sodium	0.6	1.1	4.1	-1.3	-0.6	-2.0	-0.8	-0.9	-0.7	-0.4	-0.7	0.2	-0.6	-1.1	-1.4	-1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	1.4	1.2	0.5	-0.8	-0.5	-0.6	1.1	-0.4	-1.1	-0.8	0.4	-0.2	-0.6
Pain all over the body in last month	0.6	0.6	1.7	-0.8	-1.3	-0.7	-0.5	0.7	0.3	-1.3	0.4	0.7	1.0	-0.9	0.6	0.0
Worrier / anxious feelings	0.6	1.0	2.5	-0.4	-1.3	-0.6	-1.4	-0.3	-1.3	-0.9	-1.0	-0.7	-0.4	-1.6	0.3	-1.6
Exposure to tobacco smoke at home	0.6	0.7	2.2	-0.6	0.6	-1.3	-0.6	-1.3	-0.9	0.5	-0.2	0.1	-1.0	-0.4	-1.5	-0.8
Gout (self-reported)	0.6	0.8	1.9	-1.4	-0.2	-0.3	1.3	0.9	1.1	-0.6	1.0	0.4	0.9	0.6	0.7	1.1
Medication: Amlodipine	0.6	0.8	2.4	-1.1	-1.1	-0.2	0.2	1.2	1.0	-1.0	0.5	0.8	1.6	-0.3	1.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	0.9	-0.8	1.3	0.9	0.8	0.1	-0.8	0.8	0.8	0.9	0.2	1.0	0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.5	-0.6	1.6	-0.3	0.3	0.1	0.9	1.3	0.5	0.6	-0.1	1.3	-0.3	0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.1	-0.6	-1.2	-1.5	-0.7	-0.6	-1.2	-0.9	-0.4	0.1	-0.6	-1.3	-0.6	-0.9
Diabetes diagnosed by doctor	0.6	1.0	3.9	-1.6	-0.8	-2.0	-0.6	-0.8	-0.8	-0.7	-0.3	-0.2	-0.7	-1.2	-1.2	-0.7
Medication for cholesterol	0.6	1.0	4.0	2.0	1.4	1.7	0.7	-0.4	-0.0	1.1	0.4	-0.4	-0.4	1.2	-0.4	0.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.6	0.5	0.8	1.6	1.0	0.5	0.8	0.7	0.5	-0.8	-0.1	1.2	0.7	0.9
Heart disease (siblings)	0.6	0.8	3.6	0.2	-0.5	1.2	0.0	1.2	1.0	-0.5	0.4	0.5	1.1	0.3	1.9	0.7
Pack years of smoking	0.6	0.9	2.0	-1.4	-1.4	-1.3	-0.9	0.6	-0.6	-1.3	0.5	0.2	0.3	-0.9	1.2	-0.6
Schizophrenia (2018)	0.5	1.0	2.1	1.1	0.1	0.3	-1.4	-1.1	-1.3	0.8	-1.0	-0.9	-1.3	-0.4	-0.9	-1.4
Allergy or Eczema	0.5	1.3	4.6	-0.5	0.7	-1.2	-2.1	-1.0	-0.2	0.9	-1.3	-1.6	-0.8	-0.4	-1.0	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.7	-1.6	-0.7	-1.6	-0.2	0.0	-0.1	-1.0	0.2	0.8	0.3	-1.0	-0.3	-0.3
Hand grip strength (right)	0.5	1.4	3.4	1.6	1.7	1.8	1.1	0.2	0.8	1.6	0.4	0.1	-0.1	1.8	0.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.0	0.4	-1.0	-0.7	-0.9	-0.3	-1.1	-0.7	-0.7	-0.5	-0.2	-1.4	-0.1	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	5.7	-0.6	-0.1	-1.2	-2.4	-0.6	-0.3	0.0	-1.2	-1.2	-0.4	-0.8	-0.4	-1.3
Had other major operations	0.5	0.7	3.9	-2.0	-0.6	-1.5	-0.3	0.1	0.1	-0.8	-0.4	0.2	0.1	-0.9	0.1	-0.5
Forced vital capacity (FVC)	0.5	1.8	4.2	-0.5	-1.3	0.9	2.1	1.4	1.1	-1.6	1.0	1.5	1.8	0.0	1.2	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.4	1.0	2.1	0.4	-0.0	-1.3	-0.5	1.8	-0.2	-1.0	-1.2	0.8	-1.2	-0.3
Allergy	0.5	1.1	6.3	0.8	-0.3	1.5	2.5	0.6	0.2	-0.3	1.1	0.9	0.5	0.7	0.4	1.2
Diabetes (self-reported)	0.5	0.7	2.8	-1.7	-0.8	-1.7	-0.4	-0.5	-0.3	-0.7	-0.2	-0.1	-0.4	-0.9	-0.9	-0.4
Illnesses of siblings	0.5	0.8	1.9	-0.9	0.7	-0.1	1.2	0.4	1.1	0.2	1.0	1.1	0.6	1.2	-0.4	1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.9	-0.4	-1.9	-1.0	-0.9	-0.6	-1.4	-1.7	-1.7	0.1	-0.0	-2.4	-0.6	-1.1
Medication: Lansoprazole	0.5	0.6	2.4	1.0	1.2	0.8	0.2	-0.3	0.2	1.1	-0.7	-1.6	-0.4	0.4	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.5	0.5	1.8	-1.0	-1.3	-0.6	-0.4	0.3	-0.2	-1.4	-0.6	0.1	0.5	-1.1	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.6	0.9	0.6	1.6	1.0	0.7	0.9	0.3	0.8	0.6	0.7	1.2	0.7	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.2	-0.9	-1.5	-1.2	-0.9	0.3	-0.3	-1.1	-0.3	-0.3	0.2	-1.0	0.3	-0.3
Pulse wave peak to peak time	0.5	0.6	1.8	1.0	1.3	0.9	0.6	-0.1	0.3	1.3	0.8	-0.1	-0.3	1.3	0.2	0.3
Whole body fat mass	0.5	2.0	6.3	-0.5	-1.1	-2.5	-1.7	-1.3	-1.6	-0.9	-0.8	-0.1	-0.5	-2.1	-1.5	-1.7
Age at last live birth	0.5	0.8	2.2	-0.0	-0.6	0.4	0.6	1.1	1.3	-0.8	0.5	1.0	1.5	0.2	0.7	1.3
Smoking status: Previous	0.5	0.7	1.9	-1.2	-0.9	-1.4	-0.9	-0.4	-0.0	-0.9	-0.6	0.8	0.2	-1.3	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	-0.0	-0.3	-0.5	-1.2	-0.6	-0.7	-0.1	-1.4	-0.2	-0.1	-1.3	-0.4	-1.1
Mother’s age at death	0.5	0.7	2.2	1.2	-0.1	0.5	-0.6	-0.8	-1.1	0.7	-0.6	-1.5	-0.9	-0.0	-0.1	-0.9
Medication: Atorvastatin	0.5	0.6	1.4	-1.1	-0.7	-1.0	-0.7	-0.3	-0.6	-0.9	-0.8	-1.0	-0.4	-1.2	-0.5	-0.7
Ever depressed for a whole week	0.5	0.7	1.9	1.4	1.1	1.3	0.0	0.3	0.2	1.2	-0.0	-0.5	-0.1	1.1	0.9	-0.2
Bipolar Disorder (2018)	0.4	0.7	2.3	1.0	1.5	1.2	0.4	-0.4	0.7	1.2	-0.8	-0.4	-0.2	0.6	-0.8	0.3
Bipolar Disorder or Schizophrenia	0.4	1.1	2.3	1.5	1.0	0.9	-0.8	-1.1	-0.5	1.4	-1.3	-0.9	-1.1	0.1	-1.2	-0.9
Irritable Bowel Disease (IBD)	0.4	0.9	5.3	2.3	0.4	1.7	1.5	0.1	-0.5	0.4	0.6	0.5	0.2	0.7	0.0	0.5
Crohns Disease (2012)	0.4	0.6	1.6	0.6	-0.4	0.2	0.2	-0.7	-1.3	-0.2	-1.3	-1.0	-0.7	-1.1	-0.6	-0.9
HbA1C	0.4	0.4	1.6	-0.9	-0.8	-1.3	-0.3	-0.4	-0.8	-0.4	0.3	0.6	-0.4	-0.4	-0.5	-0.2
Triglycerides	0.4	0.7	1.9	-0.6	-0.5	0.0	0.9	1.1	0.5	-0.6	1.4	0.3	1.0	0.5	1.3	0.9
Respiratory disease	0.4	1.0	4.1	0.6	2.0	0.4	-0.7	-0.5	0.4	2.0	-0.6	-0.9	-0.9	1.1	-0.3	-0.2
Hand grip strength (left)	0.4	1.1	3.9	1.6	1.1	2.0	1.3	0.3	0.6	1.1	0.3	0.2	0.0	1.5	0.7	0.9
Impedance of leg (right)	0.4	1.7	7.7	-2.8	-1.5	-1.4	-0.2	1.1	0.8	-1.7	1.0	1.4	1.2	-0.5	0.5	0.8
Fed-up feelings	0.4	0.8	2.4	-1.3	-1.5	-1.1	-0.2	0.3	-0.3	-1.5	-0.4	-0.2	0.4	-1.3	0.1	-0.5
Impedance of leg (left)	0.4	2.0	6.6	-2.6	-1.5	-1.0	0.4	1.5	1.2	-1.6	1.6	1.6	1.5	0.1	1.0	1.2
Trunk fat mass	0.4	1.7	6.0	-0.8	-1.4	-2.4	-1.5	-0.8	-1.3	-1.3	-0.6	0.2	-0.1	-2.2	-1.0	-1.3
Nervous feelings	0.4	0.7	3.1	1.8	0.3	1.4	0.2	-0.3	-0.7	0.9	-0.5	-0.9	-0.6	0.3	0.3	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	-0.1	1.2	0.5	0.8	-0.0	1.1	1.2	-0.1	-0.7	0.0	1.0	-0.3	0.5
Medication: Ramipril	0.4	0.5	2.6	0.4	-1.1	0.6	-0.3	0.8	0.1	-0.8	-0.3	-0.2	0.6	-0.5	1.6	-0.5
Father’s age at death	0.4	0.5	1.8	1.3	0.4	1.4	1.0	0.2	0.2	0.5	0.6	-0.3	0.3	0.8	0.5	0.4
Prospective memory result	0.4	0.5	1.8	0.7	0.6	1.1	0.2	0.5	0.6	0.8	0.8	0.3	0.0	1.3	0.5	0.8
Forced vital capacity (FVC), Best measure	0.4	1.5	4.8	0.1	-0.9	1.2	2.2	1.3	0.9	-1.2	1.3	1.1	1.5	0.3	1.2	1.6
Number of full brothers	0.4	0.5	2.8	-0.2	-0.3	-0.3	-0.4	-0.7	-0.6	0.1	-0.6	-1.7	-0.7	-0.6	-0.7	-0.4
Leg pain on walking	0.4	0.5	2.4	-1.1	-0.9	-1.6	-0.1	0.3	0.3	-0.8	0.4	0.6	0.6	-0.5	0.1	0.1
Mood swings	0.4	0.8	1.7	-0.1	-1.0	-1.1	-1.2	-0.5	-1.3	-0.8	-0.5	-0.8	-0.3	-1.3	-0.5	-1.2
Long-standing illness, disability or infirmity	0.4	0.5	2.5	-1.6	-0.5	-1.3	-0.9	0.1	0.0	-0.5	-0.4	0.6	-0.2	-0.7	0.3	-0.5
Medication: Aspirin	0.4	0.5	1.6	1.0	0.0	1.2	0.3	0.4	-0.1	0.2	-0.1	-1.2	-0.0	0.2	1.3	-0.1
Leg predicted mass (right)	0.4	1.9	5.5	2.3	1.1	2.3	2.0	0.8	0.9	0.8	0.7	-0.0	0.7	1.4	1.5	1.1
Arm fat mass (left)	0.4	1.8	4.6	0.0	-0.6	-2.1	-1.8	-1.4	-1.6	-0.4	-1.1	-0.3	-0.7	-2.0	-1.5	-1.7
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.1	-1.0	-0.5	-1.1	-0.3	-1.0	-0.8	-0.8	-0.1	-0.4	-1.1	0.1	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.9	-0.3	-1.3	0.1	0.7	1.0	0.3	-1.4	0.0	-0.0	1.1	-0.7	0.8	0.1
Depression (Nagel 2018)	0.3	0.4	1.4	0.1	-1.2	-0.0	-0.2	0.4	-0.4	-1.2	-0.2	-0.4	0.4	-1.1	0.6	-0.4
Worry (Nagel 2018)	0.3	0.6	1.6	-0.4	-1.3	0.2	0.5	0.9	0.0	-1.2	0.3	0.4	1.1	-0.7	1.1	-0.1
Crohns Disease (2017)	0.3	0.7	3.0	1.1	-0.8	-0.0	0.4	-0.7	-1.7	-0.5	-0.3	-0.1	-0.6	-0.9	-0.7	-1.0
Waist Hip Ratio (WHR)	0.3	1.5	3.4	-0.7	0.6	0.7	0.8	1.6	1.8	0.1	1.8	0.3	0.9	1.5	1.7	1.5
Lung FVC	0.3	1.8	5.2	-1.0	-1.8	-1.7	-0.4	-1.1	-1.4	-1.7	-0.2	0.5	-0.2	-2.0	-2.3	-0.6
Sensitivity / hurt feelings	0.3	0.6	2.5	0.5	0.8	0.4	0.3	-0.6	-0.4	1.1	-0.0	-1.6	-1.0	0.5	-0.5	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.1	-0.5	-1.4	-0.7	-0.3	0.6	-0.1	-1.2	0.4	-0.1	0.6	-0.8	0.7	-0.1
Medication: Metformin	0.3	0.4	1.1	-1.1	0.8	-0.5	0.3	0.1	0.9	0.7	0.4	0.1	-0.1	0.8	-0.3	0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-1.0	-0.6	-0.2	0.4	0.6	0.4	-1.0	0.3	0.6	0.7	-0.4	0.6	0.6
Number of incorrect matches in round	0.3	0.6	1.5	-0.1	-0.8	0.8	0.4	1.0	0.5	-0.6	0.6	1.0	0.9	0.3	1.2	0.7
Alcohol usually taken with meals	0.3	0.5	1.4	0.7	-0.5	0.9	1.2	0.7	0.3	-0.6	0.6	0.0	0.9	0.1	0.8	0.7
Neuroticism score	0.3	0.5	2.2	-0.1	-1.0	0.5	0.6	1.1	0.4	-0.8	0.5	0.3	0.9	0.0	1.5	0.1
Tense / ‘highly strung’	0.3	0.5	1.8	-0.2	-1.3	-0.2	-0.0	0.5	-0.5	-1.2	0.2	-0.1	0.6	-1.1	0.9	-0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	0.7	-1.4	-0.0	0.1	0.9	-0.5	-1.2	1.1	1.3	1.1	-0.4	1.0	0.3
Eye problems/disorders: None of the above	0.3	0.4	1.2	-0.7	-0.7	-0.8	0.5	-0.2	-0.3	-0.7	-0.4	1.1	0.1	-0.9	-0.5	-0.0
Medication: Ibuprofen	0.3	0.4	0.9	-0.6	-0.9	-0.2	-0.5	0.3	0.2	-0.8	-0.7	-1.0	0.4	-0.7	0.4	-0.2
Mean time to correctly identify matches	0.3	0.6	3.4	1.0	-0.1	1.2	1.8	0.4	0.6	-0.3	0.1	0.0	0.9	0.1	-0.3	0.5
Medication: Aspirin	0.3	0.4	2.2	1.0	0.1	1.1	0.2	0.1	-0.3	0.3	-0.3	-1.5	-0.2	0.1	0.9	-0.3
Leg fat-free mass (right)	0.3	1.8	5.2	2.3	1.0	2.3	1.9	0.8	0.9	0.8	0.7	-0.0	0.8	1.3	1.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	1.1	0.5	0.6	-0.5	-0.8	-0.6	0.6	-0.7	-1.0	-0.8	0.0	-0.8	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	-1.3	0.1	-0.4	0.3	0.5	1.2	-0.2	0.2	0.3	0.6	0.2	0.2	0.6
Miserableness	0.3	0.4	1.3	0.1	-0.7	-0.6	-0.6	-0.4	-1.0	-0.5	-0.8	-0.4	-0.2	-1.0	-0.4	-1.1
Commuting to job workplace: Public transport	0.3	0.4	1.3	-1.0	-0.3	-0.0	1.1	0.2	0.4	-0.8	0.2	-0.3	0.7	-0.4	-0.2	0.7
Fractured/broken bones in last 5 years	0.3	0.4	1.5	0.1	1.2	0.7	-0.3	-0.0	0.6	1.2	-0.2	0.3	-0.7	0.9	0.5	0.2
Commuting to job workplace: Cycle	0.3	0.4	1.2	0.2	0.8	-0.0	-1.1	-0.4	0.0	1.0	-0.1	-0.5	-0.7	0.9	-0.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.1	-0.3	0.2	0.5	0.7	0.2	-0.4	1.2	0.7	0.6	0.3	0.7	0.8
Neuroticism (Nagel 2018)	0.2	0.4	1.2	0.6	-0.6	1.1	0.9	0.9	0.3	-0.5	0.2	-0.3	0.9	0.0	1.1	-0.0
Reaction Time	0.2	0.4	1.0	0.3	-0.5	0.7	1.0	0.6	0.7	-0.8	-0.2	0.1	1.0	-0.1	0.1	0.4
LDL Cholesterol	0.2	0.4	1.0	-0.2	0.5	-0.0	0.9	0.5	0.7	0.3	1.0	0.3	0.5	0.9	0.2	0.7
Schizophrenia (2014)	0.2	0.5	1.0	0.6	-0.3	0.4	-0.9	-0.8	-0.8	0.2	-1.0	-0.8	-0.8	-0.6	-0.6	-0.9
Relative age of first facial hair	0.2	0.3	1.6	0.0	-1.3	0.1	0.0	0.4	-0.5	-1.2	-0.2	0.0	0.1	-0.8	0.5	-0.3
Leg fat-free mass (left)	0.2	0.9	3.8	1.9	0.7	1.6	1.3	0.4	0.4	0.6	0.3	-0.1	0.5	0.7	1.0	0.5
Townsend deprivation index at recruitment	0.2	0.3	1.5	-1.2	-0.5	-1.0	0.0	0.4	0.5	-0.6	0.6	-0.1	0.6	-0.4	0.1	0.0
Stomach or abdominal pain in last month	0.2	0.3	0.7	-0.7	-0.1	-0.8	-0.7	-0.1	-0.3	-0.6	-0.3	0.8	0.2	-0.7	-0.3	-0.2
Leg predicted mass (left)	0.2	0.9	3.9	2.0	0.7	1.6	1.3	0.3	0.4	0.5	0.3	-0.1	0.4	0.6	1.0	0.5
Waist circumference	0.2	0.8	1.8	0.4	0.6	-1.4	-1.4	-1.1	-0.7	0.6	-0.7	-0.6	-0.7	-0.7	-1.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	0.7	0.3	0.8	0.2	0.4	0.3	0.4	0.0	0.2	-0.1	0.7	0.7	0.2
Heart attack	0.2	0.2	1.1	-0.2	-0.3	-0.0	0.3	0.6	0.2	-0.4	1.0	0.6	0.4	0.1	0.6	0.6
Hip circumference	0.2	0.7	1.7	0.8	0.8	-0.8	-0.5	-1.3	-0.8	0.8	-0.8	-0.5	-0.7	-0.5	-1.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.6	-0.7	-1.0	-0.6	-0.0	0.0	-0.5	-0.2	0.7	0.4	-0.6	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.3	0.1	-1.2	-0.3	0.0	-0.3	-0.9	-1.2	-0.9	0.2	0.3	-1.5	-0.3	-0.6
Breastfed as a baby	0.2	0.2	0.7	0.6	0.8	0.6	-0.2	-0.3	-0.0	0.8	-0.1	-0.4	-0.5	0.6	0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	2.7	0.6	0.4	-0.1	-0.5	-0.0	-0.3	0.4	0.1	-1.6	-0.0	-0.0	0.1	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.2	0.1	-0.1	0.2	0.4	0.9	0.2	0.6	0.4	0.5	0.6	0.2	0.5
Loud music exposure frequency	0.2	0.2	1.0	0.5	1.0	0.5	0.2	-0.1	0.3	0.8	0.0	0.3	-0.1	0.6	-0.3	0.2
Arm fat-free mass (right)	0.2	0.8	4.6	2.1	1.1	1.2	0.5	-0.6	-0.4	1.1	-0.5	-0.6	-0.4	0.3	-0.0	-0.4
Health satisfaction	0.2	0.2	0.6	-0.3	-0.5	-0.7	-0.5	0.2	-0.2	-0.6	-0.2	-0.8	-0.1	-0.7	0.2	-0.6
Arm predicted mass (right)	0.2	0.9	4.7	2.2	1.2	1.6	1.1	-0.2	-0.0	1.1	-0.1	-0.4	-0.1	0.7	0.4	0.1
Alcohol intake frequency.	0.2	0.4	1.4	1.0	0.6	1.2	0.4	0.5	0.6	0.6	0.3	0.2	0.3	0.9	0.9	0.5
Number of full sisters	0.2	0.3	0.7	-0.4	-0.0	-0.4	-0.8	0.8	0.8	-0.2	0.7	-0.2	0.5	0.4	0.8	0.1
Family relationship satisfaction	0.2	0.2	0.9	0.4	-1.0	-0.0	0.0	0.1	-0.5	-0.8	-0.6	0.2	0.1	-0.7	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.1	0.5	0.4	0.7	0.2	0.7	0.5	0.3	0.5	0.3	0.8	-0.1	0.6
Illnesses of father: Heart disease	0.2	0.3	1.5	1.0	0.1	0.3	-0.1	-0.7	-1.2	0.2	-0.0	-0.3	-0.5	-0.3	-0.7	-0.4
Whole body water mass	0.2	0.9	4.0	2.0	1.0	1.7	1.2	-0.0	0.2	0.9	0.0	-0.3	0.2	0.7	0.6	0.3
Medication: Blood pressure	0.2	0.4	3.2	-0.2	-0.5	0.5	-0.2	0.9	0.5	-0.2	-0.6	0.2	0.5	-0.1	1.8	-0.0
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.2	-0.6	-0.6	-0.7	-0.4	-0.7	-0.5	0.1	0.2	-0.4	-0.6	-0.5	-0.8
Irritability	0.2	0.3	1.3	1.1	0.1	0.5	0.6	0.3	-0.1	0.2	1.0	0.8	0.4	0.5	0.5	0.1
Cholesterol lowering medication	0.2	0.3	2.4	-1.5	-0.3	-0.8	0.0	0.2	0.1	-0.3	0.4	0.3	0.1	-0.4	0.5	-0.2
Alcohol drinker status: Previous	0.2	0.2	1.4	1.2	0.1	0.5	-0.1	0.1	0.0	0.5	-0.3	-0.1	0.1	-0.0	0.5	-0.4
Ovarian Cancer	0.1	0.1	0.4	-0.6	0.5	-0.5	-0.1	-0.4	-0.2	0.5	0.4	-0.0	-0.3	0.2	-0.4	-0.1
Mean Putamen Volume	0.1	0.1	0.5	0.4	0.1	0.2	0.6	0.3	0.1	0.0	0.7	0.5	0.4	0.2	0.2	0.1
Tanning	0.1	1.6	3.0	0.5	0.3	-0.7	-1.7	-1.6	-1.7	0.7	-1.5	-0.8	-1.6	-0.8	-1.6	-1.6
Medication for hormone replacement therapy	0.1	0.1	0.5	-0.1	0.1	-0.2	0.2	-0.2	-0.1	0.1	0.4	0.7	-0.0	0.2	-0.6	0.6
Medication: Co-codamol	0.1	0.1	0.3	-0.5	-0.2	-0.3	0.5	-0.0	0.1	0.0	0.1	-0.6	-0.1	-0.1	-0.0	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	-0.0	0.8	0.5	-0.3	-0.1	0.5	0.4	-0.5	-0.0	-0.1	0.3	-0.2	0.4
Medication: Atenolol	0.1	0.1	0.6	0.0	0.3	0.5	0.6	-0.3	-0.1	0.3	-0.8	-0.3	-0.1	-0.4	-0.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	0.7	0.1	0.1	-0.5	-0.3	-0.3	0.5	-0.2	-0.9	-0.4	-0.1	0.0	-0.7
Weight	0.1	0.3	1.2	0.3	-0.5	-1.0	-0.3	-0.5	-0.6	-0.5	-0.3	0.3	0.2	-1.1	-0.4	-0.6
Trunk fat-free mass	0.1	0.5	2.8	1.7	0.9	1.3	1.0	-0.3	-0.1	0.7	-0.2	-0.3	-0.0	0.3	0.1	0.0
Alcohol intake versus 10 years previously	0.1	0.2	0.7	0.4	0.3	0.8	-0.5	0.4	0.4	0.4	0.3	-0.2	0.3	0.4	0.8	0.2
Falls in the last year	0.1	0.2	0.5	0.7	0.1	0.2	-0.7	-0.4	-0.6	0.4	0.1	-0.4	-0.4	0.0	0.0	-0.2
Happiness	0.1	0.2	0.6	-0.1	0.3	0.5	-0.3	0.3	0.3	0.3	-0.5	-0.8	-0.2	0.2	0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.6	-0.4	-0.8	-0.0	0.1	0.2	0.1	-0.8	-0.3	-0.5	0.4	-0.6	0.0	0.1
Depression (self-reported)	0.1	0.1	0.4	-0.0	-0.1	0.2	-0.6	-0.1	-0.1	0.3	-0.5	-0.4	-0.2	-0.1	0.1	-0.3
Trunk predicted mass	0.1	0.5	2.5	1.6	0.8	1.3	1.0	-0.2	-0.0	0.6	-0.1	-0.2	0.1	0.3	0.3	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.5	-0.4	0.0	-0.4	-0.7	-0.2	-0.6	-0.1	-0.3	0.2	-0.4	-0.3	-0.1	-0.4
Whole body fat-free mass	0.1	0.8	3.8	1.9	1.0	1.6	1.3	-0.0	0.2	0.8	0.1	-0.3	0.2	0.6	0.5	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.3	-0.4	0.2	0.5	-0.1	-0.6	-0.2	-0.2	0.2	-0.0	-0.4	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.5	0.2	-0.1	-0.1	-0.5	-0.5	0.3	-0.3	-0.0	-0.6	-0.3	-0.4	-0.5
Basal metabolic rate	0.1	0.5	2.8	1.7	0.7	1.1	0.9	-0.1	0.0	0.6	-0.0	-0.2	0.2	0.3	0.3	0.1
Arm fat-free mass (left)	0.1	0.4	2.9	1.7	0.8	0.9	0.9	-0.3	-0.1	0.6	-0.1	-0.1	0.1	0.1	-0.1	-0.1
Risk taking	0.1	0.2	0.7	0.8	0.2	0.5	-0.8	-0.1	-0.4	0.3	0.0	0.1	-0.5	0.3	0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.0	0.3	-0.1	-0.6	-0.3	-0.5	0.3	-0.3	-0.0	-0.5	0.0	-0.1	-0.3
Arm predicted mass (left)	0.1	0.4	2.2	1.5	0.9	0.6	0.5	-0.5	-0.2	0.8	-0.3	-0.2	-0.1	0.1	-0.2	-0.2
Hair Pigment	0.0	1.4	5.3	-1.4	-2.3	-1.5	-0.7	0.2	-0.5	-2.0	0.2	0.9	0.6	-1.6	-0.3	-0.2

Hub : Genes

MMACHC

Models

Trait associations