TWAS hub - TESK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0300	5.1e-04	0.019	0.033	0.017	0.037	0.032	2.0e-03	6.0e-05	3.3e-03	2.3e-05	8.1e-05
2	GTEx	Cells EBV-transformed lymphocytes	0.1550	0.0630	2.5e-04	0.097	NA	0.080	NA	0.097	4.7e-04	NA	1.4e-03	NA	4.5e-04
3	GTEx	Nerve Tibial	0.0716	0.0305	8.5e-05	0.000	NA	-0.004	NA	0.000	3.1e-01	NA	8.3e-01	NA	3.5e-01
4	GTEx	Pancreas	0.1390	0.0680	9.4e-04	0.072	NA	0.006	NA	0.072	5.8e-04	NA	1.6e-01	NA	5.7e-04
5	GTEx	Skin Sun Exposed Lower leg	0.0750	0.0410	3.1e-03	0.012	NA	0.040	NA	0.002	3.2e-02	NA	3.0e-04	NA	2.1e-01
6	GTEx	Testis	0.1520	0.0640	8.2e-04	0.007	NA	0.025	NA	0.038	1.4e-01	NA	2.8e-02	NA	8.4e-03
7	GTEx	Whole Blood	0.1410	0.0480	6.5e-08	0.055	NA	0.106	NA	0.094	8.6e-06	NA	5.6e-10	NA	5.0e-09
8	ROSMAP	Brain Pre-frontal Cortex	0.1621	0.0391	0.0e+00	0.199	0.186	0.200	0.197	0.198	5.8e-25	2.2e-23	3.9e-25	8.3e-25	6.3e-25
9	TCGA	Colon Adenocarcinoma	0.1720	0.1010	3.1e-04	0.017	0.042	0.043	NA	0.036	3.4e-02	1.8e-03	1.6e-03	NA	3.7e-03
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0243	0.0138	1.1e-03	0.005	0.020	0.018	NA	0.013	7.9e-02	2.0e-03	3.3e-03	NA	1.1e-02
11	TCGA	Brain Lower Grade Glioma	0.0484	0.0242	6.1e-06	0.017	0.038	0.026	NA	0.027	4.5e-03	3.4e-05	5.3e-04	NA	4.1e-04
12	TCGA	Thyroid Carcinoma	0.0250	0.0160	5.1e-03	0.010	0.013	0.012	NA	0.005	3.1e-02	1.9e-02	2.3e-02	NA	9.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Blood Platelet Count	16.8	195.2	324.0	-16.4	1.3	-9.4	3.0	-13.0	-17.3	-16.1	-18.0	-11.6	13.0	-17.4	-17.8
Blood Red Count	5.9	57.1	190.4	5.6	5.4	13.8	5.6	8.4	8.4	9.3	6.2	5.5	-0.4	8.7	5.4
Lung FEV1/FVC ratio	5.9	30.1	67.1	-5.2	-5.0	-8.2	-4.4	-4.8	-6.0	-6.6	-4.5	-6.5	0.4	-6.6	-3.9
Breast Cancer	5.8	13.9	27.8	5.3	1.9	3.7	0.5	1.8	4.2	3.2	4.7	3.9	-3.2	4.9	4.2
Hearing difficulty/problems: Yes	5.6	8.6	16.9	3.3	1.6	3.5	0.2	2.2	4.1	2.9	3.6	2.3	-2.0	3.8	3.4
Supplements: Fish oil (including cod liver oil)	5.3	6.9	12.8	-2.6	-2.5	-3.6	-2.1	-2.7	-2.9	-2.4	-2.4	-3.4	0.2	-3.2	-2.0
Number of operations (self-reported)	5.0	7.4	12.2	-3.1	-0.2	-2.4	0.4	-2.7	-3.1	-3.5	-3.3	-2.8	2.4	-3.3	-3.0
Mineral and other dietary supplements	4.9	6.6	10.8	2.8	1.9	3.2	1.4	2.7	2.8	2.3	2.7	3.3	-0.9	3.3	2.3
Fasting Glucose	4.8	5.8	9.5	-2.8	-1.6	-2.9	-1.1	-1.4	-2.7	-3.1	-2.6	-2.7	1.2	-3.0	-2.4
Supplements: Glucosamine	4.7	6.1	16.9	-2.4	-2.8	-4.1	-2.3	-2.5	-2.4	-2.6	-1.9	-2.2	-0.0	-2.9	-1.4
Had major operations	4.7	5.5	8.5	-2.8	-0.1	-2.1	0.5	-2.4	-2.8	-2.8	-2.9	-2.0	2.1	-2.9	-2.6
Qualifications: College or University degree	3.8	11.9	20.3	4.1	0.6	3.0	0.3	3.0	4.3	3.0	4.4	3.9	-2.8	4.5	4.1
Ever smoked	3.8	6.7	11.3	-3.3	-0.6	-1.7	0.3	-1.6	-3.4	-3.0	-3.4	-2.4	2.4	-3.3	-3.0
Vitamin and mineral supplements	3.7	5.1	17.3	0.8	4.2	3.4	3.6	0.3	1.4	1.5	0.4	2.3	2.1	1.8	-0.2
Current tobacco smoking	3.6	5.8	10.5	-3.2	-0.5	-2.6	-0.2	-2.7	-3.0	-2.2	-3.0	-1.2	1.7	-3.2	-2.8
Type 2 Diabetes (T2D) (2012)	3.5	4.1	8.2	-2.2	-1.2	-2.4	-0.6	-1.0	-2.9	-2.8	-2.5	-1.3	1.1	-2.5	-2.1
Smoking status: Current	3.5	5.5	10.0	-3.1	-0.8	-2.8	-0.4	-2.6	-2.9	-2.2	-2.8	-1.3	1.5	-3.2	-2.6
Myopia	3.5	5.0	9.4	-2.6	0.1	-0.3	1.1	-0.6	-2.5	-2.1	-3.0	-2.9	3.1	-2.5	-2.8
Friendships satisfaction	3.4	4.2	8.2	2.6	-1.4	0.3	-1.6	1.5	2.1	1.5	2.9	1.5	-2.8	2.2	2.7
Mouth/teeth dental problems	3.3	5.1	8.4	2.8	2.0	2.3	1.4	1.3	2.4	2.2	2.2	2.9	-1.4	2.9	2.3
Verbal and Numeric Reasoning (VNR)	3.2	7.7	15.0	3.6	0.7	1.2	0.4	2.2	3.7	3.5	3.4	2.0	-1.9	3.9	3.4
Hearing aid user	3.2	3.7	7.2	2.4	-0.7	0.2	-1.1	1.4	2.0	1.8	2.6	1.3	-2.6	2.2	2.7
Age started oral contraceptive pill	3.1	3.9	8.6	2.9	0.2	2.5	-0.1	1.4	2.3	1.6	2.4	1.1	-1.8	2.4	2.5
Ever had hysterectomy (womb removed)	3.0	3.4	6.7	-2.5	-0.7	-1.8	-0.3	-1.3	-2.2	-1.6	-2.3	-1.6	1.5	-2.6	-2.1
Systolic blood pressure, automated reading	2.9	8.3	16.6	-2.7	-2.5	-4.1	-2.0	-3.0	-3.3	-3.7	-2.6	-2.9	0.1	-3.5	-2.1
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	8.3	-2.9	-0.7	-1.2	-0.2	-1.2	-1.9	-1.6	-2.2	-2.2	1.7	-2.4	-2.1
Mouth/teeth dental problems: Dentures	2.9	4.9	9.7	-3.1	-1.1	-1.1	-0.7	-0.5	-2.5	-2.1	-2.7	-3.0	2.1	-2.9	-2.6
Smoking Status	2.7	6.5	12.0	-3.3	0.4	-1.6	0.9	-2.1	-3.3	-2.3	-3.5	-1.4	2.7	-3.2	-3.2
Migraine (self-reported)	2.7	3.4	6.1	-2.2	-0.8	-1.0	0.3	-2.3	-2.5	-2.2	-2.1	-2.1	1.0	-2.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	6.3	2.5	1.7	1.6	0.8	0.8	2.0	1.9	1.7	1.7	-1.0	2.3	1.7
Breast cancer (self-reported)	2.7	3.3	6.2	-1.9	0.1	-0.6	0.5	-1.4	-1.9	-1.9	-2.5	-1.7	2.3	-2.2	-2.5
Number of self-reported non-cancer illnesses	2.7	4.7	13.0	-2.4	-1.3	-3.6	-0.8	-1.6	-2.3	-2.6	-2.1	-2.5	0.7	-2.6	-1.6
Multivitamins +/- minerals	2.6	3.3	10.8	-0.6	-3.3	-3.2	-2.7	0.1	-1.3	-1.0	-0.3	-1.9	-1.7	-1.4	0.2
Mouth/teeth dental problems: Bleeding gums	2.6	3.3	6.5	-2.3	0.3	-1.1	0.8	-2.1	-2.0	-1.6	-2.2	-1.0	2.3	-1.9	-2.6
Fluid intelligence score	2.5	5.3	10.2	3.0	0.4	0.8	0.3	2.2	2.9	2.4	2.8	2.0	-1.8	3.2	2.9
High blood pressure (siblings)	2.5	3.6	7.4	-2.1	-1.0	-1.5	-0.4	-1.6	-2.4	-2.0	-2.2	-2.7	0.8	-2.6	-1.9
Number of children fathered	2.5	2.8	4.5	-1.7	0.8	0.2	1.4	-1.9	-2.1	-1.9	-2.1	-1.3	1.8	-1.8	-2.0
Systolic Blood Pressure	2.4	12.0	20.6	-3.8	-1.3	-3.0	-0.3	-3.4	-4.4	-4.5	-4.1	-3.7	1.7	-4.4	-3.7
Had menopause	2.4	3.1	6.9	2.6	0.2	1.2	-0.5	1.3	2.0	1.7	2.1	1.0	-2.1	2.0	2.4
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	10.0	2.1	-1.9	-1.1	-2.3	2.0	2.5	1.7	2.9	1.5	-3.2	2.1	3.1
Glaucoma (self-reported)	2.3	2.7	4.8	-1.9	0.4	-1.0	0.9	-1.2	-1.7	-1.9	-2.2	-1.5	2.0	-1.7	-2.1
Suffer from ‘nerves’	2.3	3.5	6.6	-2.0	0.8	-1.1	0.8	-1.4	-2.1	-0.9	-2.6	-2.4	2.3	-2.2	-2.5
Supplements: Calcium	2.3	2.5	7.3	-1.5	0.7	-0.4	0.6	-1.7	-2.0	-2.7	-1.9	-1.4	1.1	-1.8	-1.7
Exposure to tobacco smoke outside home	2.2	2.9	5.6	-1.5	-0.2	-2.2	-0.3	-1.3	-2.2	-2.4	-2.0	-1.5	1.2	-2.1	-1.8
Shortness of breath walking on level ground	2.2	2.6	4.5	1.4	-0.7	0.6	-1.0	2.0	1.9	1.6	2.1	1.6	-1.7	1.8	2.1
Blood White Count	2.1	15.8	41.0	-3.6	6.1	4.8	6.2	-0.6	-1.7	-0.3	-3.4	1.5	6.4	-1.1	-4.3
Intelligence (Savage-Jansen 2018)	2.0	6.3	11.8	3.4	-0.4	0.4	-0.7	1.6	3.3	2.6	3.3	1.6	-2.5	3.3	3.4
Qualifications: A levels/AS levels or equivalent	2.0	4.5	8.1	2.3	1.5	2.4	1.4	2.3	2.5	2.0	2.3	1.9	-1.1	2.8	2.2
Length of working week for main job	2.0	2.2	5.6	-1.6	1.5	0.1	1.8	-0.2	-1.3	-1.3	-1.9	-1.1	2.4	-1.2	-1.8
Leg fat percentage (right)	2.0	7.3	16.2	-3.7	-1.5	-4.0	-1.5	-2.3	-2.8	-2.0	-2.9	-2.3	1.8	-3.5	-2.6
Medication: Blood pressure	2.0	3.5	6.2	-2.4	0.4	0.0	1.2	-0.7	-2.4	-2.5	-2.5	-1.2	1.9	-2.2	-2.4
Financial situation satisfaction	2.0	2.5	7.2	-2.0	-0.6	-2.7	-0.1	-1.2	-1.4	-1.2	-1.7	-2.0	1.1	-1.7	-1.4
Prostate Cancer	1.9	2.7	6.1	-2.3	0.1	0.5	0.6	-0.8	-1.9	-1.2	-2.4	-0.6	2.3	-1.9	-2.5
Ulcerative Colitis	1.9	2.8	5.1	2.1	-0.2	1.6	-0.8	1.1	1.8	1.0	2.2	2.0	-1.9	1.9	2.0
Birth weight of first child	1.9	3.5	11.6	1.4	2.6	3.4	3.0	1.3	1.1	2.0	0.2	0.7	1.6	1.6	0.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.9	2.4	-0.0	0.3	-0.8	1.0	2.2	1.9	2.4	1.6	-1.8	2.2	2.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.7	1.5	2.2	2.2	1.6	1.4	1.7	1.7	0.9	-0.4	0.5	1.7	0.8
Cardiovascular Disease	1.8	5.8	10.1	-2.9	1.9	0.2	2.4	-2.4	-2.5	-2.0	-3.2	-1.1	3.0	-2.5	-3.2
Hair/balding pattern: Pattern 3	1.8	2.7	5.6	-2.4	0.7	-0.5	0.8	-0.8	-1.9	-1.4	-2.2	0.0	2.1	-1.9	-2.4
Overall health rating	1.8	3.8	6.5	-2.1	1.4	-0.8	1.0	-2.4	-1.8	-1.9	-2.5	-1.3	2.5	-2.0	-2.5
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	4.3	-2.1	-0.0	-1.7	0.3	-1.6	-1.6	-1.3	-1.7	-1.2	1.2	-1.7	-1.7
Average weekly red wine intake	1.8	2.7	5.2	-1.7	-0.5	-1.1	0.4	-1.3	-2.1	-1.7	-2.0	-2.3	1.5	-1.9	-1.9
Alcohol drinker status: Never	1.8	2.2	5.6	0.8	-0.7	-0.2	-0.9	1.9	1.9	2.4	1.6	1.7	-1.1	1.4	1.6
Leg fat percentage (left)	1.8	6.4	16.3	-3.5	-1.6	-4.0	-1.7	-2.2	-2.4	-1.7	-2.6	-2.1	1.6	-3.3	-2.3
Chronotype (morning person)	1.7	3.8	6.4	2.2	0.7	1.2	0.4	2.1	2.5	2.4	2.3	1.9	-1.3	2.5	2.3
Average weekly spirits intake	1.7	2.1	7.3	-0.7	-2.7	-2.7	-2.4	0.3	-0.4	-0.6	0.2	-1.4	-1.2	-0.9	0.5
Supplements: Zinc	1.7	1.9	3.0	-1.0	0.7	-0.8	1.2	-1.1	-1.6	-1.4	-1.7	-1.7	1.6	-1.4	-1.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.3	-1.6	1.1	-0.5	1.1	-0.7	-1.3	-1.5	-1.8	-0.7	1.8	-1.4	-1.8
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.1	-2.0	-1.1	-0.8	-0.8	-0.8	-1.8	-1.7	-1.6	-1.1	0.8	-2.0	-1.6
Medication: Seretide 50 evohaler	1.7	1.9	3.6	1.2	0.5	-0.5	-0.6	1.7	1.7	1.1	1.7	1.9	-1.4	1.6	1.6
Pulse rate, automated reading	1.7	5.6	20.2	0.3	4.5	4.5	3.4	-0.6	1.2	0.9	-0.2	2.5	2.0	1.1	-0.8
Ever had prostate specific antigen (PSA) test	1.7	1.9	4.2	-1.8	0.4	0.4	0.7	-0.4	-2.0	-1.6	-1.8	-0.5	1.6	-1.6	-2.0
Pulse rate	1.6	2.8	8.5	1.0	2.5	2.9	1.9	0.3	1.4	1.5	0.9	2.5	0.2	1.5	0.5
Average weekly champagne plus white wine intake	1.6	2.1	4.0	1.6	0.6	1.6	0.3	1.4	2.0	1.2	1.9	1.6	-0.8	1.9	1.5
High cholesterol (Self-reported)	1.6	2.8	7.1	-2.3	-0.2	-1.3	0.2	-0.2	-1.5	-1.1	-2.2	-2.7	1.8	-2.0	-1.9
Lupus	1.5	2.3	3.8	1.9	-1.0	0.1	-1.3	1.9	1.6	1.4	1.9	0.6	-1.7	1.6	2.0
Time employed in main current job	1.5	1.8	7.2	0.1	2.2	2.7	1.8	-0.3	0.3	0.3	-0.4	1.4	1.6	0.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.3	0.5	-1.6	-2.3	-2.1	0.7	0.4	0.0	1.0	1.1	-2.0	0.2	1.3
Neck or shoulder pain in last month	1.5	2.1	3.7	-1.9	0.3	-1.4	0.4	-1.8	-1.5	-1.7	-1.7	-0.4	1.3	-1.7	-1.7
Eye problems/disorders: Glaucoma	1.5	1.8	2.8	-1.5	-0.1	-1.4	0.1	-1.1	-1.4	-1.6	-1.7	-1.6	1.2	-1.5	-1.5
Alzheimer’s Disease (including proxy)	1.4	2.0	4.1	-1.2	-1.7	-1.4	-1.3	-1.3	-2.0	-1.8	-1.4	-0.7	-0.2	-1.9	-1.2
Heel T-Score	1.4	11.3	20.7	3.7	-2.1	0.7	-2.3	3.2	3.9	3.3	4.3	2.2	-4.2	3.6	4.5
Average weekly fortified wine intake	1.4	1.6	3.9	1.1	-0.8	-0.7	-0.8	1.1	1.5	1.1	1.8	0.3	-1.7	1.2	2.0
Eye problems/disorders: Cataract	1.4	1.7	2.9	1.3	-1.0	1.2	-1.4	0.3	1.2	1.2	1.5	1.7	-1.7	1.0	1.4
Medication: Bendroflumethiazide	1.4	2.1	5.0	-1.7	0.2	-0.1	0.1	-2.2	-1.9	-1.9	-1.7	-0.3	0.6	-1.9	-1.8
Number of treatments/medications taken	1.3	2.4	5.6	-1.5	-1.2	-2.4	-0.8	-0.8	-2.0	-1.6	-1.7	-1.7	0.1	-2.1	-1.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.5	0.9	0.7	1.4	0.6	1.5	1.6	1.2	1.1	1.5	-0.4	1.4	1.1
Taking other prescription medications	1.3	2.0	4.8	-1.4	-0.7	-2.2	-0.8	-0.6	-1.6	-1.6	-1.6	-1.4	0.7	-1.9	-1.4
Qualifications: CSEs or equivalent	1.3	1.7	3.9	-2.0	-0.0	-0.5	0.2	-1.0	-1.8	-0.7	-1.8	-0.3	1.5	-1.7	-1.9
Sitting height	1.3	9.1	48.3	1.3	4.2	7.0	5.1	0.9	1.6	1.7	0.6	0.2	1.9	2.4	0.2
Number of live births	1.3	1.8	4.0	-1.4	-0.5	-1.0	-0.6	-1.6	-2.0	-2.0	-1.4	-0.2	0.3	-1.9	-1.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	7.9	-1.8	0.3	0.1	1.3	-1.5	-2.7	-2.8	-2.4	-2.8	2.1	-2.3	-2.5
Pulse wave Arterial Stiffness index	1.3	1.5	3.0	-1.2	1.1	0.9	1.7	-0.7	-1.3	-1.1	-1.5	-0.6	1.5	-1.0	-1.5
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	-1.4	1.0	-0.4	0.8	-1.2	-1.4	-1.2	-1.6	-0.2	1.4	-1.4	-1.7
Pulse wave peak to peak time	1.3	1.5	2.5	1.4	-0.9	-0.5	-1.6	0.8	1.4	1.3	1.5	0.6	-1.5	1.1	1.6
Emphysema/chronic bronchitis	1.3	1.5	3.4	-1.8	-0.1	-1.2	0.3	-1.0	-1.7	-1.3	-1.5	-0.5	1.0	-1.6	-1.4
Comparative height size at age 10	1.3	7.2	12.4	2.6	1.3	3.5	1.7	3.4	3.5	3.5	2.7	0.4	-0.9	3.4	2.8
Vascular/heart problems diagnosed by doctor	1.3	3.7	6.7	2.0	-1.2	-0.0	-1.3	2.2	2.1	2.6	2.4	0.9	-1.8	2.2	2.4
Coronary Artery Disease (CAD)	1.2	1.4	2.8	-1.4	-1.7	-1.4	-1.3	-0.3	-1.2	-1.4	-0.8	-1.1	0.0	-1.5	-0.7
Primary Biliary Cirrhosis	1.2	1.7	6.0	-0.7	-1.8	-1.4	-1.3	-0.9	-1.2	-1.4	-0.8	-2.5	-0.2	-1.4	-0.6
High blood pressure	1.2	3.3	6.2	-1.9	1.3	0.1	1.4	-2.0	-2.0	-2.5	-2.4	-0.7	1.7	-2.1	-2.3
High blood pressure (mother)	1.2	1.7	3.2	-1.8	-0.7	-1.6	-0.4	-1.0	-1.4	-1.4	-1.6	-0.8	0.8	-1.7	-1.5
Pulse wave reflection index	1.2	1.4	3.5	-1.2	-0.6	-0.7	0.1	-0.8	-1.9	-1.6	-1.4	-1.3	0.6	-1.6	-1.3
Comparative body size at age 10	1.2	3.3	12.0	-1.3	-2.4	-3.5	-1.9	-1.7	-1.4	-1.2	-1.0	-2.1	-0.4	-2.0	-0.7
Hypertension (Self-reported)	1.2	3.3	6.5	-1.9	1.0	-0.1	1.2	-1.9	-2.1	-2.5	-2.4	-0.8	1.6	-2.2	-2.3
Loneliness, isolation	1.2	1.7	6.8	0.9	2.6	1.8	2.2	0.1	0.6	1.0	0.1	0.7	1.1	1.1	-0.2
Wears glasses or contact lenses	1.2	1.4	3.9	-0.3	-1.9	-2.0	-1.8	-0.2	-0.9	-0.9	-0.1	-1.1	-1.3	-0.8	0.3
Alzheimer’s Disease (in father)	1.1	1.2	2.9	-1.2	-0.5	-0.7	0.1	-0.6	-1.7	-1.1	-1.5	-0.9	0.5	-1.5	-1.3
BMI	1.1	6.5	26.0	-2.7	-2.9	-5.1	-2.8	-2.6	-2.0	-1.9	-1.5	-1.7	0.2	-2.8	-1.1
Diabetes (mother)	1.1	1.4	2.5	-1.2	1.0	-0.5	0.8	-1.1	-1.5	-1.3	-1.4	0.2	1.2	-1.3	-1.6
Body mass index (BMI)	1.1	4.6	15.9	-2.3	-2.1	-4.0	-2.1	-2.5	-1.8	-1.6	-1.6	-1.7	0.4	-2.5	-1.3
Past tobacco smoking	1.1	2.0	4.0	1.7	-0.1	0.9	-0.5	0.7	1.8	1.7	2.0	1.2	-1.7	1.7	1.6
Financial difficulties in last 2 years	1.1	1.5	2.9	-1.6	0.3	-1.6	0.1	-1.7	-1.0	-0.6	-1.3	-1.3	1.3	-1.4	-1.4
Illnesses of mother	1.1	1.4	3.8	1.3	0.6	1.9	0.9	1.5	1.1	1.2	1.1	0.7	-0.2	1.5	1.0
Leg fat mass (right)	1.1	4.1	11.0	-2.7	-1.6	-3.3	-1.4	-2.2	-1.8	-1.4	-1.8	-1.8	1.0	-2.5	-1.5
Illnesses of siblings: Diabetes	1.1	1.3	2.2	-1.4	-0.8	-0.9	-0.2	-1.3	-1.5	-0.9	-1.4	-0.9	0.9	-1.5	-1.4
Ever had bowel cancer screening	1.1	1.3	4.3	-0.5	1.7	2.1	1.7	0.1	-0.2	-0.4	-0.9	0.5	1.8	-0.2	-1.1
Back pain experienced in last month	1.1	1.6	6.6	-0.5	-1.9	-2.6	-2.0	-1.0	-0.6	-1.3	-0.0	-0.2	-1.1	-0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	4.9	-1.3	-1.1	-1.6	-0.7	-1.1	-1.9	-2.2	-1.3	-2.2	0.4	-1.8	-1.2
Alzheimer’s Disease (in mother)	1.0	1.2	2.1	-0.9	-1.4	-1.1	-1.0	-1.2	-1.4	-1.4	-0.9	-0.8	-0.1	-1.3	-0.9
Ulcerative Colitis (UC)	1.0	1.8	4.6	1.6	-0.0	2.1	-0.4	1.4	1.2	0.8	1.5	1.8	-1.2	1.4	1.1
Rheumatoid Arthritis	1.0	1.4	4.4	-0.8	1.3	-0.1	1.7	-0.1	-0.8	-0.1	-1.4	-1.4	2.1	-0.8	-1.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	2.9	-1.7	-0.2	-1.5	0.1	-0.9	-1.7	-1.5	-1.6	-1.3	1.1	-1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.3	-1.6	-0.3	-0.3	-0.3	-1.2	-1.4	-1.8	-1.2	-0.9	0.9	-1.5	-1.3
Worrier / anxious feelings	1.0	2.0	3.7	-1.1	-0.1	-0.1	0.0	-1.9	-1.7	-1.5	-1.8	-1.7	1.1	-1.7	-1.9
Body fat percentage	1.0	3.8	9.6	-2.9	-0.9	-3.1	-0.8	-2.0	-1.7	-1.0	-2.0	-1.8	1.5	-2.4	-1.7
Medication: Ibuprofen	1.0	1.2	2.6	-0.5	1.6	1.2	1.3	-1.2	-0.9	-1.4	-1.0	0.7	1.0	-0.6	-1.1
Chest pain or discomfort	1.0	1.5	2.7	-1.6	-0.7	-1.6	-0.4	-1.0	-1.2	-1.3	-1.3	-1.3	0.7	-1.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.0	1.5	-0.7	-0.4	-0.9	0.5	0.6	-0.1	1.3	0.8	-2.0	0.8	1.6
Mother’s age at death	1.0	1.2	4.8	-0.7	-1.4	-0.9	-1.2	-2.2	-1.0	-1.1	-0.7	-1.0	-0.5	-1.1	-0.6
Illnesses of father: High blood pressure	1.0	1.2	2.4	-1.5	0.0	-0.6	0.3	-1.3	-1.3	-1.1	-1.4	-0.7	0.9	-1.4	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.3	-0.6	-1.6	-1.0	-1.1	-0.6	-1.4	-1.1	-0.8	-1.8	-0.4	-1.3	-0.5
Body Mass Index (BMI) (2010)	0.9	1.2	2.6	-1.0	-1.0	-1.6	-0.7	-0.4	-1.2	-1.4	-1.0	-1.4	0.3	-1.4	-0.8
Crohns Disease (2012)	0.9	1.5	4.5	-0.5	-0.2	0.2	0.1	-1.7	-1.4	-2.0	-1.1	-2.1	0.3	-1.3	-1.1
Fed-up feelings	0.9	1.6	3.0	-0.8	1.3	0.4	1.2	-1.4	-1.3	-1.5	-1.5	-0.8	1.6	-1.1	-1.7
Hair/balding pattern: Pattern 2	0.9	1.2	3.8	1.9	0.7	0.7	0.1	1.0	1.1	0.9	1.1	0.9	-1.0	1.3	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.5	1.2	-1.6	-1.6	-1.9	0.8	1.3	0.5	1.7	0.3	-2.1	1.0	1.9
Medication: Simvastatin	0.9	1.3	2.6	-1.6	0.6	-1.0	0.9	-1.1	-0.8	-0.3	-1.4	-1.2	1.6	-0.9	-1.3
Arm fat percentage (right)	0.9	3.5	10.1	-2.6	-0.9	-3.2	-0.8	-2.0	-1.6	-1.3	-1.8	-1.8	1.3	-2.3	-1.5
Noisy workplace	0.9	1.1	7.1	-0.9	-1.1	-2.7	-1.4	-0.7	-0.5	-0.4	-0.3	-0.9	-0.3	-0.7	-0.1
Medication: Cholesterol lowering	0.9	1.5	3.1	-1.8	0.3	0.0	0.9	-0.4	-1.1	-0.6	-1.6	-1.5	1.8	-1.2	-1.5
Medication: Allopurinol	0.9	1.2	3.0	0.4	1.7	1.0	1.5	1.1	1.1	1.5	0.3	0.9	0.8	1.1	0.2
Heart disease (mother)	0.9	1.1	3.5	0.5	-1.6	-1.1	-1.9	0.0	0.4	0.1	1.0	-0.2	-1.6	0.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.2	-1.3	0.2	-0.9	0.9	-0.1	-1.2	-0.9	-1.5	-0.3	1.3	-1.1	-1.2
Knee pain experienced in last month	0.9	1.5	7.1	-1.2	-1.7	-2.7	-1.8	-1.2	-0.4	-0.1	-0.4	0.1	-0.0	-1.1	-0.3
Mood swings	0.9	1.6	4.7	-1.5	-0.2	-1.0	-0.1	-2.2	-1.4	-1.3	-1.3	-1.0	0.9	-1.6	-1.4
Leg fat mass (left)	0.9	3.5	10.4	-2.5	-1.6	-3.2	-1.4	-2.1	-1.5	-1.0	-1.6	-1.7	0.9	-2.3	-1.3
Depression (Nagel 2018)	0.8	1.2	2.1	-1.2	0.5	0.7	0.7	-1.1	-0.9	-1.5	-1.2	-1.2	1.2	-1.1	-1.2
Crohns Disease (2017)	0.8	1.8	3.9	-1.1	-1.2	0.3	-0.9	-2.0	-1.5	-1.8	-1.3	-1.4	0.5	-1.7	-1.4
Neuroticism (2016)	0.8	1.2	3.6	1.2	-1.3	-0.1	-1.6	-0.3	0.6	0.6	1.3	0.7	-1.9	0.6	1.1
Height	0.8	15.9	78.7	3.5	4.3	8.9	5.5	2.0	3.0	3.0	2.3	0.6	0.9	4.2	2.2
Respiratory disease	0.8	1.9	3.8	1.6	-0.3	-0.9	-1.2	-0.1	1.4	1.0	1.6	1.6	-2.0	1.4	1.9
Age when periods started (menarche)	0.8	2.0	4.4	-1.7	0.7	0.2	0.8	-1.1	-1.2	-1.0	-1.9	-1.6	2.1	-1.4	-1.8
Medication: Ramipril	0.8	1.1	6.2	-0.6	0.2	0.7	0.9	-0.5	-0.9	-0.6	-1.1	-2.5	0.9	-0.8	-0.9
Illnesses of siblings	0.8	1.2	4.2	1.0	0.7	0.3	0.4	1.1	1.2	0.9	1.1	2.0	-0.4	1.4	0.9
Impedance of arm (right)	0.8	3.7	11.8	0.3	3.4	3.0	3.4	1.8	1.0	1.3	-0.1	0.9	1.8	1.4	-0.3
Impedance of arm (left)	0.8	3.8	12.3	0.6	3.5	3.3	3.5	1.5	1.0	1.4	0.1	0.9	1.5	1.5	-0.1
Standing height	0.8	7.5	28.6	2.3	2.7	5.3	3.5	1.8	2.7	2.6	2.0	0.8	0.3	3.3	1.8
Exposure to tobacco smoke at home	0.8	0.9	4.7	-0.4	-1.4	-2.2	-1.4	0.7	0.3	0.5	0.3	-0.6	-0.6	-0.1	0.5
Medication: Omeprazole	0.8	0.9	2.4	-0.6	-1.6	-0.9	-1.1	0.1	-1.1	-1.0	-0.6	-1.5	-0.3	-1.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.5	0.8	1.3	2.3	1.8	1.4	1.0	1.9	0.7	0.7	0.3	1.4	0.5
Arm fat percentage (left)	0.8	3.4	10.4	-2.4	-0.9	-3.2	-0.9	-2.3	-1.6	-1.2	-1.7	-1.7	1.1	-2.2	-1.4
Qualifications: nursing, teaching	0.8	1.2	3.1	1.4	-0.6	0.6	-1.1	0.2	0.9	0.3	1.3	1.3	-1.8	0.9	1.5
Commuting to job workplace: Walk	0.8	0.8	2.7	1.0	-0.8	-0.3	-0.7	-1.4	-0.4	-0.7	0.7	1.2	-1.6	0.2	0.7
Medication for cholesterol	0.8	1.2	2.2	0.9	-1.4	0.1	-1.1	1.2	1.0	0.5	1.5	0.9	-1.4	1.0	1.4
Ever taken oral contraceptive pill	0.8	0.9	2.7	-1.4	1.0	0.6	1.6	0.4	-0.4	0.4	-0.9	-0.3	1.6	-0.2	-1.1
Diastolic blood pressure, automated reading	0.8	2.4	4.3	-1.9	0.7	-0.4	0.7	-1.6	-1.9	-2.1	-2.1	-0.3	1.4	-1.9	-2.0
Pain experienced in last month	0.8	1.4	5.3	1.1	0.9	2.3	1.1	1.5	1.1	1.2	0.9	0.0	-0.2	1.3	0.8
Depressed Affect (Nagel 2018)	0.7	1.5	3.9	-0.3	1.9	1.1	1.4	-2.0	-0.8	-1.2	-1.1	-0.8	1.4	-0.6	-1.3
HbA1C	0.7	0.8	2.0	-1.3	-0.9	-1.3	-0.6	-0.6	-0.5	-0.3	-0.8	-1.4	0.5	-0.9	-0.7
HDL Cholesterol	0.7	1.2	6.0	-0.5	-1.3	-2.4	-1.4	-0.9	-1.0	-1.0	-0.3	-0.4	-0.8	-0.9	-0.2
Waist Hip Ratio (WHR)	0.7	3.0	9.9	1.4	1.1	2.2	0.7	3.1	2.0	1.8	1.4	1.4	-0.4	1.8	1.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.6	-0.1	-1.3	-1.9	-1.7	-0.3	-0.0	-0.5	0.2	-0.7	-1.1	-0.4	0.5
Diabetes (father)	0.7	0.8	2.8	-1.7	-0.2	-1.1	-0.1	-0.0	-0.7	-0.4	-1.0	-0.3	1.3	-1.0	-1.2
Trunk fat percentage	0.7	2.8	7.0	-2.6	-0.4	-2.4	-0.2	-1.8	-1.4	-0.7	-1.8	-1.6	1.6	-2.0	-1.6
Hand grip strength (right)	0.7	1.8	3.3	1.7	-0.6	-0.1	-0.8	0.5	1.5	1.7	1.8	0.7	-1.7	1.5	1.8
Maternal smoking around birth	0.7	1.0	2.2	-1.5	1.0	-0.6	0.6	0.0	-1.1	-0.5	-1.3	0.5	1.2	-1.0	-1.3
Relative age voice broke	0.7	1.1	3.4	-0.7	1.3	1.9	1.4	0.3	-0.2	-0.5	-0.8	0.2	1.6	-0.3	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.6	0.8	0.8	0.7	0.6	1.3	0.7	0.3	0.8	1.9	-0.5	0.9	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.7	0.3	-1.3	-2.2	-1.4	0.0	0.3	-0.0	0.5	-0.2	-1.3	0.1	0.8
Arm fat mass (right)	0.7	2.9	10.3	-2.1	-1.4	-3.2	-1.2	-2.0	-1.3	-1.0	-1.3	-1.7	0.7	-1.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	-0.9	0.5	-0.8	0.3	-0.1	-1.0	-0.9	-1.4	-1.2	1.1	-1.2	-1.2
Family relationship satisfaction	0.7	0.9	2.2	-0.4	0.4	0.5	0.7	-1.5	-1.2	-1.0	-1.1	-0.8	0.9	-0.8	-1.1
Supplements: Vitamin C	0.7	0.9	2.5	0.1	-1.5	-1.3	-1.6	-0.7	-0.6	-0.7	-0.2	-1.2	-0.9	-0.8	0.1
Osteoarthritis (self-reported)	0.7	1.0	2.7	-0.9	0.5	-1.6	0.3	-0.6	-0.9	-1.2	-1.2	-0.1	1.1	-1.0	-1.1
Illnesses of father: None of the above (group 1)	0.7	0.8	3.3	0.8	1.6	0.9	1.1	-0.0	0.5	0.3	0.4	1.8	0.2	0.9	0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.2	1.5	0.4	-0.4	-0.4	0.0	1.1	1.0	1.1	1.1	-1.1	1.0	1.3
Bipolar Disorder (2018)	0.6	1.0	2.2	1.2	0.0	0.1	0.3	1.3	0.7	0.9	1.3	0.9	-1.1	1.3	1.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	-1.1	0.9	0.9	0.9	0.2	-0.6	-0.0	-1.2	-0.3	1.4	-0.6	-1.4
LDL Cholesterol	0.6	0.9	2.5	0.7	-0.7	0.3	-0.3	1.6	1.2	1.4	0.9	0.3	-0.6	1.0	1.1
Blood Eosinophil Count	0.6	4.5	12.3	-2.5	2.9	1.2	3.5	0.6	-1.1	-0.5	-2.3	-0.3	3.5	-0.9	-2.3
Hypothyroidism (self reported)	0.6	1.3	6.0	-1.2	0.0	-2.4	0.0	-0.9	-1.0	-0.8	-1.1	-1.4	0.9	-1.1	-0.8
Neuroticism	0.6	1.3	5.9	1.2	1.9	2.4	1.3	-0.7	0.9	0.4	0.6	0.3	0.3	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.7	-1.3	0.4	0.4	0.6	-0.8	-0.9	-1.0	-1.2	-0.6	1.3	-0.9	-1.2
Relative age of first facial hair	0.6	1.2	2.3	-1.0	0.7	0.8	0.9	-1.1	-1.2	-1.3	-1.2	-0.2	1.3	-1.1	-1.5
Pack years adult smoking proportion	0.6	0.9	1.9	-1.4	0.3	-0.5	0.3	-0.8	-0.5	0.1	-1.2	-0.8	1.3	-1.2	-1.4
Trunk fat mass	0.6	2.6	5.9	-2.4	-0.7	-2.4	-0.4	-2.1	-1.3	-0.8	-1.6	-1.7	1.3	-1.9	-1.3
Pain all over the body in last month	0.6	0.6	1.6	-0.8	1.0	0.4	0.7	-0.6	-0.5	-0.4	-0.9	-1.1	1.3	-0.5	-0.9
Asthma	0.6	1.3	4.4	0.4	-1.3	-2.1	-1.9	-0.9	0.2	-0.1	0.7	1.2	-1.5	0.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	-0.5	1.2	1.4	1.0	-0.6	-0.8	-1.1	-0.8	0.6	0.9	-0.4	-0.9
Tense / ‘highly strung’	0.6	1.1	3.5	-0.8	-0.2	0.6	0.3	-1.1	-0.9	-0.8	-1.2	-1.9	1.2	-1.0	-1.2
Headache pain in last month	0.6	1.1	2.5	-0.8	0.7	-0.3	0.7	-1.3	-1.6	-1.2	-1.4	-0.3	0.8	-1.1	-1.2
Medication: Amlodipine	0.6	0.8	2.5	-0.5	1.6	1.5	1.3	-0.2	-0.1	-0.7	-0.7	0.4	1.2	0.0	-0.8
Birth weight	0.6	1.2	3.5	0.4	0.8	1.5	1.4	1.4	1.0	1.9	0.2	-1.0	1.1	1.0	0.3
Worry too long after embarrassment	0.6	1.1	4.1	1.6	0.6	2.0	0.8	0.0	0.8	1.0	1.0	0.2	-0.4	1.3	0.6
Whole body fat mass	0.6	2.7	7.8	-2.3	-1.3	-2.8	-1.0	-2.1	-1.3	-0.8	-1.4	-1.6	0.9	-1.9	-1.1
Age at last live birth	0.6	0.9	3.3	0.4	1.8	1.5	1.7	0.1	0.0	-0.4	-0.1	0.8	0.9	0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.7	-0.8	-0.2	-1.1	-0.0	-0.9	-0.9	-0.8	-0.8	-1.6	0.4	-0.9	-0.6
Asthma (self-reported)	0.6	1.1	3.9	0.4	-1.0	-2.0	-1.7	-1.1	0.2	-0.1	0.6	1.3	-1.3	0.1	0.7
Osteoporosis (self-reported)	0.6	0.8	2.3	-0.1	1.2	1.0	1.5	1.3	0.4	1.0	-0.2	-0.1	0.9	0.6	-0.2
Arm fat mass (left)	0.6	2.3	7.6	-1.8	-1.3	-2.8	-1.1	-2.1	-1.1	-0.9	-1.0	-1.5	0.5	-1.7	-0.8
Medication: Atorvastatin	0.6	0.8	1.8	-0.7	0.1	0.8	0.8	0.3	-1.0	-1.1	-1.1	-1.3	0.8	-0.8	-0.9
Unable to work because of sickness or disability	0.6	0.8	2.6	-0.9	-0.7	-1.6	-0.4	-0.7	-1.2	-0.4	-1.1	-0.4	0.4	-1.2	-1.0
Impedance of whole body	0.6	3.0	8.7	-0.1	3.0	2.6	2.9	2.2	0.6	1.3	-0.3	0.8	1.7	1.0	-0.5
Major Depression (MDD)	0.5	0.6	2.5	-0.3	-1.6	-1.1	-1.4	0.1	-0.4	0.1	-0.1	-0.5	-0.7	-0.5	-0.0
Lung FVC	0.5	2.4	4.7	-1.9	-0.2	0.0	0.2	-1.2	-2.2	-2.0	-1.9	-1.0	1.8	-1.9	-2.1
Angina	0.5	0.6	1.6	-1.2	0.3	-0.4	0.3	0.6	-0.4	-0.5	-1.0	-1.0	1.3	-0.7	-0.8
Medication: Metformin	0.5	0.7	1.4	1.1	0.2	-0.5	0.1	0.9	1.0	1.0	0.9	0.7	-0.7	1.0	1.2
Severe depression (siblings)	0.5	0.6	2.1	0.6	-1.4	0.3	-0.9	-0.8	-0.8	-0.6	-0.1	-0.3	-1.1	-0.7	-0.0
Medication: Levothyroxine sodium	0.5	0.8	4.0	-0.7	-0.2	-2.0	-0.3	-0.6	-0.8	-0.2	-0.9	-1.4	0.5	-1.0	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.8	-0.7	-0.4	-1.3	-0.2	0.7	0.2	0.9	0.2	-1.3	0.3	1.0
Qualifications: None of the above	0.5	1.0	3.1	-1.2	0.9	0.0	0.6	0.3	-0.5	0.1	-1.3	-1.5	1.8	-0.9	-1.2
Prospective memory result	0.5	0.6	2.3	0.5	-0.1	0.5	-0.3	1.0	0.7	0.9	0.9	1.5	-0.7	0.8	0.6
Lung cancer (father)	0.5	0.6	1.8	-0.8	-0.2	-1.3	-0.4	-0.5	-0.7	-1.1	-0.7	0.4	0.3	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.9	-1.1	0.1	0.1	0.9	-1.0	-1.6	-1.6	-1.4	-2.2	1.4	-1.3	-1.4
Peak expiratory flow (PEF)	0.5	1.2	3.4	-0.5	-1.1	-1.9	-0.5	-1.4	-1.2	-1.5	-0.6	-1.5	-0.4	-1.0	-0.2
Loud music exposure frequency	0.5	0.5	1.3	0.6	-0.3	-0.8	-0.3	0.1	0.9	0.8	0.9	0.0	-0.8	0.8	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	6.8	-0.6	-0.9	-2.6	-1.0	-0.6	-0.8	-0.4	-0.5	-1.2	0.0	-0.8	-0.2
Age at first live birth	0.5	0.8	2.1	1.0	1.3	1.5	1.3	0.1	0.8	0.8	0.6	0.7	0.2	1.2	0.5
Eye problems/disorders: None of the above	0.5	0.6	2.7	-0.8	-0.0	-0.3	0.7	0.2	-0.9	-0.4	-0.8	-1.7	0.9	-0.6	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.7	0.6	1.6	1.5	1.3	0.6	0.7	0.7	0.2	0.7	0.9	0.8	-0.1
Leg pain on walking	0.5	0.6	2.0	-0.9	0.7	-1.3	0.4	-1.4	-0.4	-0.1	-0.5	0.4	1.0	-0.3	-0.5
Illnesses of father: Heart disease	0.5	0.8	3.8	-0.7	-2.0	-0.6	-1.3	0.0	-0.5	-0.5	-0.2	-1.2	-0.3	-0.7	-0.1
Diabetes diagnosed by doctor	0.5	0.8	1.5	-1.1	-0.3	-1.2	0.1	-0.3	-0.9	-0.8	-1.1	-1.0	0.8	-1.1	-0.8
Medication: Gliclazide	0.5	0.6	1.2	-0.7	-0.1	-0.6	-0.3	-1.1	-1.1	-1.0	-0.7	-0.8	0.2	-1.1	-0.7
Miserableness	0.5	0.9	2.7	-0.6	-0.0	-0.5	-0.2	-1.6	-1.0	-1.4	-0.9	-0.8	0.6	-1.0	-1.1
Commuting to job workplace: Public transport	0.5	0.6	4.1	0.1	0.8	2.0	1.3	0.7	-0.2	-0.4	-0.3	-0.1	0.7	0.3	-0.2
Medication: Paracetamol	0.5	0.8	2.5	-0.5	-0.9	-1.6	-1.2	-1.1	-0.9	-0.7	-0.5	0.4	-0.8	-1.0	-0.4
Ever depressed for a whole week	0.5	0.6	1.6	1.1	-0.3	0.6	-0.9	0.0	0.8	0.6	1.0	0.2	-1.3	0.7	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.4	1.0	-0.9	-0.8	-0.8	1.2	0.3	1.0	0.5	0.4	-1.0	0.5	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.9	0.3	0.8	0.2	0.5	0.9	1.0	1.0	0.7	-0.8	1.1	0.9
Heart disease (siblings)	0.5	0.6	3.0	0.3	1.3	1.7	1.2	-0.3	0.2	0.2	-0.1	-0.1	0.6	0.3	-0.1
Pack years of smoking	0.5	0.8	1.6	-1.3	0.2	-0.6	0.1	-0.7	-0.5	-0.2	-1.2	-0.8	1.2	-1.1	-1.3
Schizophrenia (2018)	0.4	0.8	2.5	-0.4	-1.2	-0.8	-1.6	-1.2	-0.8	-0.9	-0.5	-0.5	-0.6	-1.1	-0.4
Worry (Nagel 2018)	0.4	0.9	1.6	-0.2	1.1	1.3	0.8	-1.0	-0.7	-0.7	-1.1	-1.2	1.2	-0.7	-1.2
Reaction Time	0.4	0.9	3.5	0.2	1.6	1.9	1.7	-0.2	-0.4	-0.1	-0.3	0.6	0.8	0.2	-0.6
Age at First Birth	0.4	0.6	1.1	0.9	0.4	1.0	0.4	0.2	0.9	0.6	1.0	0.3	-0.6	1.1	0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.8	-0.1	1.0	1.3	1.3	0.8	0.1	0.4	-0.3	-0.3	0.8	0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.4	-0.1	-0.5	-1.0	-0.9	-1.8	-0.2	-0.9	-0.1	-0.4	-0.4	-0.3	0.0
Hearing difficulty/problems with background noise	0.4	0.7	3.7	0.4	0.9	1.9	0.8	0.2	0.8	0.5	0.6	-0.7	-0.1	0.8	0.6
Forced vital capacity (FVC)	0.4	1.5	5.3	-0.0	1.6	2.3	2.3	0.3	-0.4	-0.3	-0.6	-0.5	1.6	0.1	-0.8
Medication: Lansoprazole	0.4	0.5	1.3	1.1	-0.1	-0.1	-0.2	-0.8	0.6	0.2	0.8	-0.1	-1.0	0.6	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	0.9	0.0	0.8	0.4	1.2	0.9	0.9	0.9	0.3	-0.4	1.0	1.0
Medication: Paracetamol	0.4	0.6	2.3	-0.3	-1.1	-1.5	-1.1	-0.3	-0.8	-0.5	-0.3	-0.2	-0.9	-0.8	-0.2
Gout (self-reported)	0.4	0.6	1.8	0.7	1.3	0.8	1.1	0.7	0.6	0.6	0.2	0.8	0.4	0.7	0.2
Angina (self-reported)	0.4	0.5	1.6	-1.1	0.3	-0.2	0.3	0.8	-0.3	-0.3	-0.9	-0.9	1.3	-0.6	-0.8
Mean time to correctly identify matches	0.4	0.7	4.8	0.5	1.2	2.2	1.0	0.0	-0.1	-0.0	0.1	1.1	0.3	0.4	-0.2
Number of full sisters	0.4	0.4	1.2	0.5	0.6	0.3	-0.2	1.1	0.8	1.1	0.4	0.9	-0.1	0.6	0.5
Long-standing illness, disability or infirmity	0.4	0.5	2.2	-0.5	1.0	-1.5	0.5	-0.9	-0.1	-0.2	-0.6	-0.9	0.5	-0.5	-0.3
Guilty feelings	0.4	0.5	1.9	0.5	1.0	1.4	0.9	-0.3	0.4	0.6	-0.1	-1.1	0.6	0.3	-0.3
Medication: Blood pressure	0.4	0.7	3.0	0.2	1.4	0.7	1.0	-1.7	-0.3	-0.5	-0.7	-0.1	0.4	-0.2	-0.6
Ovarian Cancer	0.3	0.4	1.0	0.1	-1.0	-1.0	-1.0	0.6	0.7	0.4	0.5	-0.5	-0.6	0.2	0.6
Bipolar Disorder (2011)	0.3	0.3	1.0	0.5	-0.9	-0.3	-0.5	0.0	0.2	-0.1	0.8	0.1	-1.0	0.5	0.8
Allergy or Eczema	0.3	0.8	6.3	0.3	-0.2	-2.5	-0.6	-1.6	-0.1	-0.2	0.2	-0.1	-0.7	-0.0	0.3
Sensitivity / hurt feelings	0.3	0.5	1.5	0.7	-1.2	0.2	-1.2	-0.4	0.3	0.1	0.6	-0.5	-1.0	0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.8	-0.4	0.9	-0.9	0.3	-0.4	-0.2	0.0	-0.5	-0.8	0.9	-0.3	-0.4
Impedance of leg (right)	0.3	1.6	6.0	-1.1	1.6	1.1	1.7	2.5	-0.3	0.5	-0.9	0.1	1.6	-0.1	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	5.2	-0.5	0.0	-2.3	-0.0	-1.5	-0.4	-0.6	-0.4	-0.3	0.1	-0.4	-0.3
Impedance of leg (left)	0.3	1.5	6.2	-0.9	1.6	1.2	1.6	2.5	0.0	1.0	-0.7	0.2	1.5	0.2	-0.8
Nervous feelings	0.3	0.6	1.6	0.7	-0.6	0.8	-1.2	-1.3	-0.4	-0.7	-0.1	-0.8	-0.8	-0.4	-0.1
Had other major operations	0.3	0.4	1.3	-0.1	0.9	-0.4	0.9	0.1	-0.2	-0.5	-0.7	-1.2	0.8	-0.3	-0.6
Heart attack	0.3	0.4	1.9	-0.7	-0.8	-0.1	-0.2	1.4	0.4	-0.1	-0.1	-1.0	0.3	-0.0	0.2
Allergy	0.3	0.7	6.6	0.3	0.0	2.6	0.2	1.2	0.1	0.2	0.1	0.2	0.2	0.2	-0.1
Diabetes (self-reported)	0.3	0.5	0.9	-0.7	0.1	-1.0	0.4	-0.4	-0.8	-0.6	-1.0	-0.7	0.8	-0.8	-0.6
Neuroticism score	0.3	0.7	2.3	0.1	1.2	1.0	0.9	-1.5	-0.4	-0.4	-0.6	-0.8	0.9	-0.2	-0.9
Hip circumference	0.3	1.2	5.9	-0.6	-1.7	-2.4	-1.4	-1.1	0.1	0.3	0.4	-0.5	-0.8	-0.3	0.6
Falls in the last year	0.3	0.3	1.4	-0.4	-1.1	-1.2	-1.0	-0.1	0.0	-0.1	0.0	-0.2	-0.4	-0.4	0.2
Happiness	0.3	0.4	1.6	1.3	0.9	1.0	0.6	-0.6	0.1	-0.1	0.1	0.7	-0.2	0.4	0.1
Breastfed as a baby	0.3	0.3	0.8	0.3	-0.7	-0.7	-0.6	0.4	0.5	0.4	0.6	0.1	-0.9	0.3	0.8
Number of full brothers	0.3	0.4	1.1	-0.4	-0.3	0.8	-0.1	-0.6	-0.9	-1.0	-0.7	0.3	0.2	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.6	-0.0	0.6	1.6	0.4	-0.2	-0.1	-0.2	-0.3	0.6	0.6	-0.3	-0.7
Health satisfaction	0.3	0.4	2.7	-0.3	0.7	-0.1	0.5	-1.6	-0.3	-0.4	-0.5	0.1	0.6	-0.4	-0.5
Alcohol intake frequency.	0.3	0.7	1.8	0.9	0.3	0.4	-0.3	-0.2	1.0	1.4	0.9	1.3	-0.8	0.8	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.2	1.0	0.4	1.0	-0.7	0.6	0.1	-0.1	-0.1	0.7	0.4	-0.0
Smoking status: Previous	0.3	0.5	1.2	-0.5	0.5	0.3	0.7	-0.3	-0.8	-0.8	-1.0	-0.4	1.1	-0.5	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.0	-0.0	0.9	-0.1	-0.8	-0.7	-0.8	-0.6	-0.4	0.3	-0.6	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.8	-0.6	-0.8	0.0	-0.1	1.3	0.5	-0.0	-0.0	-1.0	0.3	0.0	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.4	-0.9	-0.5	-1.0	-0.4	-0.1	-0.2	0.4	0.2	-1.1	-0.0	0.6
Neuroticism (Nagel 2018)	0.2	0.5	2.2	0.3	0.9	1.2	0.5	-1.5	-0.1	-0.4	-0.4	-1.0	0.4	-0.2	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	2.4	0.4	-0.9	1.5	-0.9	-0.0	-0.1	-0.4	0.3	0.2	-0.5	-0.1	-0.1
Schizophrenia (2014)	0.2	0.4	1.0	-0.3	-0.3	0.3	-0.5	-0.9	-1.0	-0.8	-0.8	-0.6	0.1	-0.9	-0.6
Triglycerides	0.2	0.3	1.5	0.3	0.3	1.2	0.5	0.5	0.4	0.6	-0.0	0.2	0.4	0.3	-0.0
Hand grip strength (left)	0.2	0.7	1.4	0.9	-0.3	-0.1	-0.2	0.2	0.9	1.2	1.1	0.1	-1.1	0.9	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.8	-0.3	0.8	-0.8	0.1	-0.7	0.2	-0.3	-0.1	0.9	0.3	-0.1	-0.2
Medication: Atenolol	0.2	0.2	1.6	0.3	0.2	0.4	0.2	-0.3	-0.1	-0.8	-0.1	-1.3	-0.2	-0.1	0.2
Waist circumference	0.2	0.8	4.7	-0.4	-1.3	-2.2	-1.4	-0.6	0.3	0.3	0.3	-0.2	-0.7	-0.3	0.6
Number of incorrect matches in round	0.2	0.4	1.2	-0.2	0.9	1.1	0.8	-0.0	-0.2	0.4	-0.6	-0.5	0.7	-0.2	-0.6
Alcohol usually taken with meals	0.2	0.3	0.8	-0.5	0.0	0.3	0.7	-0.4	-0.3	-0.8	-0.2	-0.9	0.6	-0.1	-0.2
Weight	0.2	0.7	2.5	-1.1	-0.8	-1.3	-0.4	-1.6	-0.4	-0.2	-0.5	-1.1	0.5	-0.8	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.5	0.2	0.8	-0.2	0.2	0.7	0.9	0.5	0.8	-0.4	0.4	0.6
Father’s age at death	0.2	0.3	0.6	0.7	-0.8	0.3	-0.7	-0.2	0.4	0.1	0.5	-0.1	-0.7	0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.2	-0.9	0.4	-1.1	0.2	-0.8	-0.5	-0.6	-0.6	-0.5	0.6	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.4	-0.8	-0.3	-1.2	-0.5	0.5	-0.2	0.3	-0.3	-0.6	-0.1	0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-1.3	-0.1	0.2	-0.4	0.2	-0.6	-0.5	-1.0	-0.3	1.1	-1.0	-1.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.5	0.9	-0.1	0.3	-0.3	0.4	0.9	0.5	0.8	-0.1	0.6	0.4
Blood clot in the leg (DVT)	0.2	0.3	1.0	-0.6	-0.8	-0.8	-0.4	0.5	-0.2	-0.2	-0.3	-1.0	-0.1	-0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.2	0.0	-0.6	-1.1	-0.6	-0.2	-0.3	-0.2	-0.3	-0.2	-0.3	-0.4	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	3.8	0.1	0.9	2.0	1.6	0.4	-0.0	0.3	-0.1	-0.6	1.1	0.3	-0.3
Arm fat-free mass (right)	0.2	0.8	2.4	0.4	-1.6	-0.8	-1.1	-1.1	0.4	0.2	0.8	-0.8	-1.1	0.2	1.1
Wheeze or whistling in the chest in last year	0.2	0.4	2.9	-0.4	0.1	-1.7	-0.6	-0.6	-0.0	0.1	-0.4	0.9	0.1	-0.5	-0.3
Arm predicted mass (right)	0.2	0.8	1.8	0.7	-1.3	-0.4	-0.9	-0.9	0.8	0.5	1.1	-0.6	-1.2	0.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.6	-0.1	-0.2	0.1	0.3	0.5	0.4	0.6	0.5	-0.4	0.8	0.7
Medication: Aspirin	0.2	0.3	2.3	0.0	-0.6	0.3	-0.2	-0.8	-0.0	0.2	-0.1	-1.5	-0.3	-0.4	0.2
Leg fat-free mass (right)	0.2	0.9	2.0	1.1	-0.4	0.5	-0.1	-1.0	1.2	0.9	1.3	0.0	-0.9	1.1	1.4
Medication: Aspirin	0.2	0.2	1.7	0.1	-0.4	0.5	-0.1	-0.6	0.1	0.3	-0.1	-1.3	-0.2	-0.2	0.2
Leg predicted mass (right)	0.2	1.0	2.2	1.1	-0.5	0.5	-0.1	-0.9	1.3	0.9	1.4	0.0	-1.0	1.1	1.5
Medication: Lisinopril	0.2	0.3	1.0	0.1	0.8	0.7	1.0	0.9	0.5	-0.0	0.0	0.2	0.6	0.5	-0.1
Average weekly beer plus cider intake	0.2	0.4	1.0	-0.6	-1.0	-0.5	-0.5	0.2	-0.5	-0.3	-0.6	-1.0	0.3	-0.7	-0.5
Irritability	0.2	0.3	1.2	-0.2	-0.6	-0.9	-1.1	-0.5	0.6	0.3	0.5	-0.1	-0.3	0.1	0.4
Risk taking	0.2	0.3	0.9	-0.2	-0.8	-0.9	-0.8	-0.7	0.0	-0.5	0.1	0.3	-0.4	-0.1	0.0
Cholesterol lowering medication	0.2	0.2	2.1	-0.1	0.0	-0.4	-0.1	0.3	0.3	0.5	-0.3	-1.4	0.3	-0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.4	-0.9	-0.9	-0.5	0.4	-0.0	-0.1	-0.0	-0.8	-0.4	-0.2	0.2
Alcohol drinker status: Previous	0.2	0.2	1.0	0.3	-0.3	-0.5	-0.5	-0.9	-0.1	0.1	0.0	-1.0	-0.3	-0.1	0.3
Mean Putamen Volume	0.1	0.2	0.5	-0.1	-0.5	0.0	-0.6	0.4	0.7	0.5	0.4	0.2	-0.2	0.1	0.3
Hair Pigment	0.1	2.8	5.2	-2.0	0.2	0.2	1.0	-1.8	-1.9	-2.0	-2.1	-0.1	2.2	-1.7	-2.3
Tanning	0.1	0.9	2.1	-0.8	-1.4	-1.5	-1.3	-0.3	-1.0	-0.6	-0.3	-1.4	-0.5	-1.0	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.7	-0.4	0.0	-0.2	-0.2	0.2	0.1	0.3	0.2	0.8	-0.0	0.1	0.0
Medication: Co-codamol	0.1	0.1	0.7	-0.1	0.2	-0.0	0.1	0.1	-0.2	0.3	-0.2	-0.8	0.1	-0.3	-0.0
Leg fat-free mass (left)	0.1	0.5	1.6	0.6	-0.6	0.1	-0.2	-1.3	0.8	0.4	0.9	-0.2	-0.7	0.6	1.0
Leg predicted mass (left)	0.1	0.5	1.7	0.5	-0.6	0.1	-0.2	-1.3	0.8	0.4	0.9	-0.3	-0.6	0.5	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.5	0.2	0.1	0.0	-0.5	0.2	0.2	0.3	-0.1	-0.4	0.3	0.2
Trunk fat-free mass	0.1	0.4	1.4	0.4	-1.2	-0.2	-0.5	-0.6	0.5	0.0	0.8	-0.7	-0.7	0.3	0.9
Depression (self-reported)	0.1	0.1	0.3	-0.0	0.2	0.1	-0.2	-0.5	-0.3	-0.5	-0.3	0.4	-0.1	-0.3	-0.2
Trunk predicted mass	0.1	0.4	1.0	0.4	-1.0	-0.1	-0.4	-0.6	0.5	0.0	0.7	-0.7	-0.6	0.4	0.9
Whole body fat-free mass	0.1	0.6	1.3	0.6	-1.0	-0.1	-0.5	-0.9	0.8	0.3	1.0	-0.5	-0.9	0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.0	-0.5	0.2	-0.3	-0.6	-0.4	-0.3	0.1	0.7	-0.4	-0.3	-0.1
Whole body water mass	0.1	0.6	1.4	0.7	-1.0	-0.1	-0.5	-0.9	0.8	0.4	1.1	-0.4	-0.9	0.7	1.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.7	0.4	-0.4	-0.2	-0.8	-0.4	-0.0	-0.3	0.1	0.5	-0.3	-0.1	0.2
Basal metabolic rate	0.1	0.5	1.1	0.3	-1.0	-0.5	-0.5	-1.0	0.6	0.3	0.8	-0.6	-0.7	0.3	0.9
Arm fat-free mass (left)	0.1	0.4	1.4	0.3	-1.2	-0.5	-0.8	-0.7	0.5	0.1	0.8	-0.6	-0.7	0.3	0.9
Arm predicted mass (left)	0.1	0.5	1.5	0.3	-1.2	-0.8	-0.8	-0.8	0.5	0.2	0.8	-0.5	-0.8	0.3	0.9
Townsend deprivation index at recruitment	0.0	0.1	0.3	0.0	0.2	-0.1	0.2	-0.1	0.3	0.3	-0.2	-0.2	0.5	0.0	-0.1

Hub : Genes

TESK2

Models

Trait associations