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chr19:43,422,999-45,202,640

Best TWAS P=9.63e-18 · Best GWAS P=1.42e-16 conditioned to 0.32

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KCNN4	0.22	0.21	bslmm	438	0.20	5.3e-24	5.3	-5.4	7.8e-08	0.76	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LYPD5	0.38	0.44	lasso	9	0.45	4.3e-60	5.3	-5.9	3.1e-09	0.78	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF404	0.18	0.23	lasso	3	0.23	3.8e-27	-7.6	-7.7	1.3e-14	0.66	0.46	0.54	FALSE
4	GTEx	Adipose Subcutaneous	ZNF404	0.16	0.13	enet	8	0.13	8.3e-11	-7.6	-7.9	2.4e-15	0.67	0.43	0.57	FALSE
5	GTEx	Adipose Visceral Omentum	ZNF404	0.19	0.14	lasso	6	0.13	4.4e-07	-7.6	-7.7	1.5e-14	0.63	0.38	0.59	FALSE
6	GTEx	Adrenal Gland	RP11-15A1.3	0.11	0.00	lasso	11	0.00	5.1e-01	-7.6	-6.7	2.3e-11	0.51	0.11	0.20	FALSE
7	GTEx	Artery Aorta	ZNF404	0.15	0.10	lasso	8	0.08	5.2e-05	-7.5	-7.6	2.4e-14	0.67	0.30	0.68	FALSE
8	GTEx	Artery Coronary	ZNF404	0.24	0.18	lasso	6	0.13	4.7e-05	-7.6	-7.4	1.0e-13	0.64	0.15	0.67	FALSE
9	GTEx	Artery Tibial	ZNF404	0.22	0.22	lasso	6	0.21	1.9e-16	-7.6	-7.7	9.7e-15	0.66	0.41	0.59	FALSE
10	GTEx	Brain Caudate basal ganglia	ZNF404	0.25	0.19	enet	24	0.14	8.5e-05	-6.8	-6.7	1.9e-11	0.61	0.44	0.34	FALSE
11	GTEx	Brain Hypothalamus	KCNN4	0.26	0.10	lasso	4	0.14	3.2e-04	5.3	-6.4	1.2e-10	0.88	0.02	0.92	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	ZNF404	0.22	-0.01	enet	15	0.00	4.2e-01	-7.5	-5.2	2.2e-07	0.56	0.06	0.34	FALSE
13	GTEx	Brain Putamen basal ganglia	ZNF404	0.33	0.29	enet	12	0.25	1.0e-06	-7.5	-6.9	6.1e-12	0.62	0.28	0.70	FALSE
14	GTEx	Breast Mammary Tissue	ZNF404	0.09	0.04	enet	5	0.06	3.4e-04	-7.6	-7.7	1.2e-14	0.67	0.27	0.58	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ZNF404	0.31	0.09	lasso	3	0.06	1.6e-02	-7.5	-7.3	2.6e-13	0.63	0.11	0.24	FALSE
16	GTEx	Breast Mammary Tissue (Male)	ZNF155	0.39	0.22	lasso	8	0.11	1.3e-03	-5.0	-5.7	9.7e-09	0.60	0.04	0.71	FALSE
17	GTEx	Breast Mammary Tissue (Male)	RP11-15A1.7	0.29	0.17	lasso	6	0.14	4.8e-04	-5.0	-6.8	1.2e-11	0.64	0.03	0.82	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RP11-15A1.3	0.25	0.13	lasso	6	0.14	2.9e-05	-7.6	-7.1	9.1e-13	0.76	0.06	0.91	FALSE
19	GTEx	Colon Transverse	ZNF404	0.10	0.15	lasso	3	0.13	1.0e-06	-7.6	-7.6	3.1e-14	0.65	0.31	0.65	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	ZNF404	0.23	0.08	enet	21	0.13	2.1e-05	-7.5	-7.0	3.0e-12	0.57	0.16	0.59	FALSE
21	GTEx	Esophagus Mucosa	ZNF404	0.10	0.13	lasso	3	0.13	8.9e-09	-7.6	-7.6	3.1e-14	0.65	0.41	0.59	FALSE
22	GTEx	Esophagus Muscularis	ZNF404	0.08	0.09	lasso	3	0.11	5.0e-07	-7.6	-7.6	3.1e-14	0.65	0.43	0.55	FALSE
23	GTEx	Esophagus Muscularis	RP11-15A1.3	0.11	0.03	lasso	5	0.05	4.1e-04	-7.6	-7.2	7.6e-13	0.62	0.23	0.74	FALSE
24	GTEx	Heart Atrial Appendage	ZNF404	0.16	0.13	enet	10	0.13	2.0e-06	-7.5	-7.8	8.6e-15	0.68	0.22	0.77	FALSE
25	GTEx	Heart Atrial Appendage	PINLYP	0.22	0.00	enet	43	0.06	7.3e-04	4.3	8.1	6.1e-16	-0.39	0.07	0.41	TRUE
26	GTEx	Heart Left Ventricle	ZNF404	0.18	0.13	enet	28	0.12	5.8e-07	-5.0	-5.9	3.9e-09	0.43	0.58	0.38	FALSE
27	GTEx	Lung	ZNF404	0.11	0.14	lasso	8	0.14	1.2e-10	-7.6	-7.8	5.5e-15	0.69	0.35	0.65	FALSE
28	GTEx	Muscle Skeletal	ZNF404	0.11	0.10	enet	11	0.10	3.4e-10	-7.6	-7.8	4.1e-15	0.63	0.44	0.56	FALSE
29	GTEx	Nerve Tibial	KCNN4	0.17	0.00	enet	19	0.02	1.0e-02	-8.2	-5.3	9.7e-08	0.56	0.01	0.94	FALSE
30	GTEx	Nerve Tibial	ZNF404	0.29	0.25	enet	33	0.27	4.3e-19	-7.6	-8.3	9.1e-17	0.57	0.41	0.59	FALSE
31	GTEx	Pancreas	ZNF404	0.14	0.13	enet	13	0.10	6.0e-05	-7.6	-5.5	4.6e-08	0.43	0.28	0.48	FALSE
32	GTEx	Pituitary	ZNF404	0.28	0.00	enet	29	-0.01	4.7e-01	-1.6	-5.2	1.6e-07	0.51	0.07	0.10	FALSE
33	GTEx	Skin Sun Exposed Lower leg	ZNF404	0.19	0.09	enet	15	0.12	6.0e-10	-7.6	-8.2	3.4e-16	0.68	0.46	0.54	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-15A1.3	0.07	0.03	lasso	4	0.02	8.0e-03	-7.6	-7.9	3.3e-15	0.69	0.30	0.46	FALSE
35	GTEx	Stomach	ZNF404	0.17	0.11	enet	12	0.10	2.0e-05	-7.6	-7.7	1.1e-14	0.67	0.48	0.41	FALSE
36	GTEx	Stomach	RP11-15A1.3	0.10	0.07	lasso	3	0.02	4.0e-02	-7.6	-7.6	3.1e-14	0.65	0.19	0.59	FALSE
37	GTEx	Thyroid	ZNF404	0.16	0.08	enet	7	0.08	1.2e-06	-7.6	-7.8	5.3e-15	0.61	0.44	0.56	FALSE
38	GTEx	Thyroid	RP11-15A1.3	0.08	0.01	lasso	5	0.02	8.0e-03	-7.6	-7.6	3.4e-14	0.54	0.11	0.76	FALSE
39	GTEx	Whole Blood	KCNN4	0.16	0.12	lasso	6	0.11	3.2e-10	-8.2	-8.3	1.3e-16	0.85	0.00	1.00	FALSE
40	NTR	Blood	KCNN4	0.06	0.07	lasso	11	0.07	5.4e-22	-8.2	-8.4	3.5e-17	0.86	0.01	0.99	FALSE
41	YFS	Blood	KCNN4	0.25	0.22	enet	55	0.26	7.1e-85	-8.2	-7.5	6.0e-14	0.76	0.00	1.00	FALSE
42	YFS	Blood	ZNF404	0.01	0.01	lasso	2	0.01	1.4e-03	-7.6	-7.5	9.5e-14	0.67	0.27	0.66	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF404	0.04	0.03	blup	44	0.03	1.5e-07	-7.6	-7.5	6.8e-14	0.65	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	ZNF404	0.10	0.07	enet	5	0.08	1.5e-03	-7.5	-7.6	2.7e-14	0.59	0.02	0.88	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF404	0.04	0.05	enet	14	0.05	6.3e-06	-7.6	-6.7	2.4e-11	0.63	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KCNN4	0.03	0.02	blup	58	0.01	9.0e-03	-8.2	-8.6	9.6e-18	0.88	0.00	0.95	TRUE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF283	0.02	0.01	blup	62	0.02	6.0e-03	-7.6	-8.1	6.6e-16	0.75	0.04	0.62	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF404	0.09	0.17	enet	13	0.17	9.8e-19	-7.6	-7.7	1.5e-14	0.66	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF404	0.05	0.01	blup	44	0.03	4.5e-03	-7.6	-7.2	4.3e-13	0.64	0.02	0.86	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	KCNN4	0.06	0.06	lasso	2	0.04	1.1e-05	5.3	-5.3	1.1e-07	0.77	0.47	0.52	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF404	0.06	0.09	lasso	2	0.09	2.5e-10	-7.6	-7.6	2.3e-14	0.65	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF404	0.02	0.03	lasso	1	0.03	1.4e-04	-7.5	-7.5	5.9e-14	0.64	0.02	0.91	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF404	0.04	0.00	lasso	4	0.00	2.8e-01	-3.9	-6.4	1.9e-10	0.53	0.02	0.57	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZNF404	0.03	0.01	enet	4	0.02	2.0e-02	-7.6	-6.8	7.2e-12	0.65	0.02	0.70	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF404	0.06	0.07	enet	5	0.04	9.1e-03	-7.5	-7.6	4.1e-14	0.63	0.02	0.88	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF404	0.08	0.03	enet	7	0.01	1.4e-01	-7.6	-7.7	1.1e-14	0.66	0.02	0.82	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF404	0.07	0.13	enet	9	0.12	1.6e-12	-7.6	-7.4	1.5e-13	0.67	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF404	0.08	0.01	enet	5	0.02	1.2e-02	1.9	-5.5	4.5e-08	0.48	0.02	0.37	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	LYPD5	0.08	0.13	lasso	4	0.12	6.3e-12	5.3	-5.3	1.0e-07	0.76	0.97	0.03	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF404	0.12	0.18	lasso	5	0.18	9.1e-18	-7.6	-7.6	2.1e-14	0.67	0.02	0.98	FALSE