Hub : Genes

KCNN4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2190	0.0410	4.4e-16	0.206	0.171	0.198	0.201	0.199	1.5e-24	2.7e-20	1.3e-23	5.3e-24	1.1e-23
2	GTEx	Brain Caudate basal ganglia	0.2250	0.0820	5.2e-03	0.107	NA	0.197	NA	0.243	5.6e-04	NA	2.6e-06	NA	1.3e-07
3	GTEx	Brain Frontal Cortex BA9	0.4350	0.1444	7.8e-03	-0.007	NA	0.093	NA	0.052	5.5e-01	NA	2.0e-03	NA	1.7e-02
4	GTEx	Brain Hypothalamus	0.2570	0.1020	5.2e-03	0.101	NA	0.075	NA	0.143	2.4e-03	NA	8.1e-03	NA	3.2e-04
5	GTEx	Nerve Tibial	0.1696	0.0622	4.9e-03	0.002	NA	0.022	NA	0.021	2.2e-01	NA	1.0e-02	NA	1.1e-02
6	GTEx	Testis	0.3800	0.0810	9.5e-09	0.379	NA	0.324	NA	0.367	7.4e-18	NA	5.6e-15	NA	3.3e-17
7	GTEx	Whole Blood	0.1590	0.0420	9.5e-08	0.121	NA	0.104	NA	0.109	3.0e-11	NA	7.5e-10	NA	3.2e-10
8	NTR	Blood	0.0558	0.0143	4.9e-14	0.073	0.052	0.065	0.068	0.071	2.2e-22	3.0e-16	3.6e-20	6.3e-21	5.4e-22
9	YFS	Blood	0.2504	0.0376	0.0e+00	0.224	0.243	0.260	0.258	0.249	1.3e-71	1.6e-78	7.1e-85	3.8e-84	1.4e-80
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0268	0.0152	3.9e-03	0.019	0.014	0.005	NA	0.010	2.6e-03	9.0e-03	8.0e-02	NA	2.3e-02
11	TCGA	Brain Lower Grade Glioma	0.0583	0.0251	2.1e-05	0.059	0.033	0.038	NA	0.043	3.1e-07	1.1e-04	3.2e-05	NA	1.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.1	3.7	-0.4	1.9	1.5	-0.6	-0.2	0.5	-1.1	-1.3	-0.6	-1.1	-0.5
Bipolar Disorder or Schizophrenia	0.5	1.2	5.0	0.5	2.0	2.2	-0.3	-1.0	-0.6	-0.7	-0.8	-0.7	-0.9	0.2
Depressed Affect (Nagel 2018)	1.8	3.8	9.2	1.6	-0.3	0.5	2.0	3.0	-2.2	2.4	2.7	1.6	1.5	1.8
Depression (Nagel 2018)	0.2	0.3	1.0	0.2	0.3	-0.1	0.3	0.1	-0.7	-0.7	-0.3	-1.0	-1.0	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	1.0	0.1	-0.0	-1.0	-0.3	-0.1	1.0	-0.3	-0.5	-0.1	-0.1	-0.4
Neuroticism (Nagel 2018)	0.8	1.8	4.4	1.4	0.7	1.3	1.7	0.8	-2.1	1.3	1.6	0.8	0.8	1.6
Schizophrenia (2018)	0.4	0.7	2.7	0.9	0.9	1.6	0.1	-1.2	-1.2	-0.0	-0.0	-0.4	-0.3	0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	3.4	-0.5	-0.9	-1.2	-0.3	-1.8	0.2	-0.2	0.0	-0.0	0.3	-0.7
Worry (Nagel 2018)	0.2	0.4	2.1	0.3	0.9	0.9	0.3	-1.5	-0.2	-0.3	-0.1	-0.3	-0.1	0.3
Alzheimer’s Disease (in mother)	5.2	6.1	9.7	-2.8	-0.9	-1.5	-3.1	-1.8	2.7	-2.7	-2.9	-2.4	-2.2	-3.0
Alzheimer’s Disease (in father)	1.0	1.0	3.4	0.2	1.8	1.1	-0.3	-0.8	-0.3	-1.3	-1.4	-0.9	-1.2	0.1
Alzheimer’s Disease (including proxy)	5.7	8.2	15.4	-2.9	-0.5	-0.8	-3.4	-2.1	2.4	-3.8	-3.9	-3.0	-3.4	-3.0
Crohns Disease (2017)	0.7	1.5	4.0	-0.3	0.6	-0.2	-0.3	-1.7	0.4	-1.8	-1.6	-2.0	-1.6	-0.2
Irritable Bowel Disease (IBD)	0.6	1.3	3.1	-1.0	0.4	-0.3	-1.0	-1.8	0.9	-1.4	-1.4	-1.5	-1.3	-0.8
Ulcerative Colitis (UC)	0.2	0.3	0.9	-0.9	-0.1	-0.5	-0.9	-0.8	0.6	-0.0	-0.2	-0.0	-0.1	-0.8
Major Depression (MDD)	1.1	1.4	3.8	-1.3	-1.3	-1.6	-1.5	-0.2	2.0	-0.4	-0.5	-0.8	-0.7	-1.4
Reaction Time	1.4	2.8	7.7	2.3	0.6	0.9	2.8	-0.1	-0.9	1.6	1.5	0.6	2.0	2.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	-0.4	-1.3	-1.2	-0.7	-0.9	1.3	-0.8	-1.0	-0.8	-0.5	-0.6
Breast Cancer	15.8	38.1	73.6	-5.4	0.9	-0.5	-6.4	-5.3	4.6	-8.3	-8.4	-7.5	-8.6	-5.3
Ovarian Cancer	0.5	0.6	2.0	0.6	0.1	1.1	0.9	-0.1	-1.4	0.0	0.4	1.2	-0.2	1.0
Prostate Cancer	0.4	0.6	1.9	-0.5	-1.2	-1.0	-0.6	0.0	0.6	-0.4	-0.6	-1.4	0.1	-0.7
Age at First Birth	0.6	0.8	2.1	0.4	0.8	-0.2	0.7	-0.6	-1.4	1.2	1.2	1.1	0.9	0.6
Bipolar Disorder (2011)	0.4	0.4	2.0	0.6	1.4	1.2	0.2	-0.3	-0.1	-0.4	-0.3	-0.1	-0.4	0.5
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	0.2	0.3	0.6	-0.2	-0.7	-0.7	-0.0	-0.0	-0.4	-0.9	0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.6	0.0	0.2	-0.3	-0.3	-1.2	1.1	-0.3	-0.4	-1.0	-0.2	-0.0
Crohns Disease (2012)	0.3	0.5	1.3	0.3	0.4	0.3	0.3	-1.1	-0.0	-1.0	-1.0	-1.0	-0.9	0.5
Mean Putamen Volume	0.4	0.4	2.3	0.0	-0.4	-0.5	-0.1	1.5	0.9	-0.0	-0.2	-1.1	-0.1	-0.1
Fasting Glucose	0.4	0.4	1.3	-0.0	-0.1	0.4	0.1	0.6	-0.5	1.2	1.0	1.0	0.8	0.4
HbA1C	0.5	0.6	1.8	-0.5	0.2	0.2	0.2	-1.3	0.5	-1.0	-0.9	-0.7	-1.2	-0.4
HDL Cholesterol	0.1	0.2	0.7	0.1	0.8	0.7	0.1	0.1	-0.8	-0.4	-0.3	0.0	-0.6	0.2
LDL Cholesterol	0.9	1.4	4.3	-1.2	-0.1	-1.0	-1.1	-0.8	0.9	-1.8	-1.5	-0.3	-2.1	-0.8
Lupus	1.1	1.6	4.2	-1.5	-0.9	-2.0	-1.6	-0.6	1.4	-0.7	-0.8	-1.2	-0.2	-1.8
Neuroticism (2016)	1.1	1.6	2.9	1.4	0.4	0.8	1.6	0.8	-0.9	1.7	1.6	0.9	1.5	1.6
Primary Biliary Cirrhosis	0.2	0.2	1.5	0.2	1.2	0.1	0.2	-0.4	-0.3	-0.3	-0.4	-0.0	-0.4	0.4
Rheumatoid Arthritis	0.6	0.9	2.5	-1.0	-1.0	-0.9	-0.9	1.3	1.6	-0.0	-0.5	0.4	-0.2	-1.0
Schizophrenia (2014)	0.6	1.4	5.0	0.4	2.1	2.2	0.0	-1.8	-0.3	-0.7	-0.7	-0.9	-0.7	0.2
Triglycerides	0.1	0.2	1.0	0.4	-0.4	-0.6	0.4	-0.0	0.4	0.3	0.2	-1.0	0.5	0.3
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.3	0.3	1.3	1.4	0.2	-1.3	1.3	-1.3	-1.5	-1.5	-1.2	0.3
Ulcerative Colitis	1.0	1.5	3.3	-1.5	-0.3	-0.3	-1.5	-1.3	1.8	-1.2	-1.5	-1.1	-0.7	-1.2
Blood Eosinophil Count	0.2	1.3	2.8	-0.8	-1.7	-0.9	-1.1	-0.7	-0.1	-1.4	-1.1	-1.5	-1.4	-0.7
Blood Platelet Count	0.2	2.2	8.4	-1.5	-2.9	-0.7	-1.4	0.8	1.1	-0.8	-1.1	-2.3	-0.9	-1.5
Blood Red Count	0.6	5.5	11.6	-2.2	-3.4	-2.3	-2.7	-0.5	2.7	-1.9	-1.6	-2.0	-1.9	-3.1
Blood White Count	1.0	7.1	13.8	-2.3	-2.2	-1.0	-2.3	-1.8	2.0	-3.5	-3.5	-3.7	-3.3	-2.4
Heel T-Score	0.6	4.8	9.4	-2.7	-1.8	-0.7	-2.1	-3.1	2.3	-2.8	-2.1	-1.6	-1.6	-2.3
BMI	0.4	2.0	4.8	-1.7	-1.0	-2.2	-1.8	-1.8	0.8	-0.7	-0.6	-0.5	-1.5	-1.8
Height	0.0	0.9	4.3	-0.6	0.3	-1.0	-0.0	1.2	-2.1	0.5	0.8	0.9	-0.8	-0.3
Waist Hip Ratio (WHR)	2.2	10.1	14.7	-3.7	-2.6	-2.6	-3.6	-2.4	3.8	-3.2	-3.0	-2.8	-3.2	-3.7
Systolic Blood Pressure	0.1	0.4	1.6	-0.2	-0.8	-0.1	0.1	0.7	0.3	0.8	0.9	0.3	1.2	-0.2
Smoking Status	0.1	0.2	1.1	0.4	0.4	-0.3	0.5	-1.1	-0.1	0.0	-0.2	-0.3	0.1	0.6
Allergy or Eczema	0.7	1.8	4.9	0.3	1.7	0.9	-0.1	-1.1	-0.0	-2.2	-1.8	-1.5	-2.1	0.5
Cardiovascular Disease	1.0	3.4	5.1	-1.7	-2.3	-1.9	-1.9	-1.7	1.7	-2.1	-1.8	-1.8	-1.6	-1.7
Hypothyroidism (self reported)	1.6	3.7	6.8	-1.6	-1.1	-0.9	-2.0	-1.5	1.9	-2.4	-2.6	-2.6	-1.7	-1.9
Respiratory disease	0.0	0.1	0.5	-0.1	-0.1	-0.1	0.1	0.7	-0.3	0.0	0.0	-0.0	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.3	-0.6	-0.7	-0.5	0.2	0.8	0.0	-0.1	-0.3	0.4	-0.7
Lung FEV1/FVC ratio	0.2	1.0	3.3	-0.9	-0.6	-0.7	-1.1	-1.8	-0.0	-1.1	-0.8	-1.1	-0.9	-1.0
Lung FVC	0.0	0.2	0.4	0.6	-0.2	-0.0	0.4	-0.6	0.3	-0.4	-0.4	-0.6	0.2	0.4
Neuroticism	0.4	1.0	2.8	0.8	-0.4	0.2	1.1	0.8	-1.4	1.4	1.7	0.6	0.8	0.9
Chronotype (morning person)	1.9	4.4	6.7	2.3	0.9	1.1	2.4	0.5	-2.6	2.5	2.6	2.0	2.4	2.3
Hair Pigment	0.4	12.2	21.3	4.6	3.8	3.6	4.2	1.0	-3.4	3.2	2.9	2.5	3.4	4.5
Tanning	0.0	0.4	1.0	-1.0	-0.8	-0.2	-1.0	-0.5	-0.4	-0.3	-0.4	0.2	-0.6	-0.6
Hand grip strength (left)	0.1	0.4	1.0	0.8	0.7	0.4	0.3	-0.3	-0.7	-0.5	-0.3	-1.0	-0.8	0.7
Number of treatments/medications taken	1.2	2.1	4.2	-1.4	-2.1	-1.2	-1.4	-0.3	0.9	-1.6	-1.3	-2.0	-1.6	-1.3
Average weekly spirits intake	1.3	1.6	5.0	-1.4	-2.2	-1.9	-1.5	0.4	1.0	-0.1	-0.0	-0.7	-0.5	-1.6
Sensitivity / hurt feelings	0.9	1.6	3.7	1.1	0.3	0.4	1.2	0.7	-1.5	1.9	1.9	1.0	1.4	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.5	-0.7	-0.6	-0.5	0.0	-0.3	-0.6	-0.8	-0.5	-1.1	-1.2	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-0.3	0.2	0.4	-0.1	-1.3	0.2	-0.9	-0.8	-0.8	-1.1	-0.1
Relative age of first facial hair	0.3	0.5	1.5	-0.6	-0.8	-0.6	-0.7	-0.5	1.2	-0.8	-1.0	-0.4	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.0	-0.4	0.9	0.9	-0.9	-0.9	0.4	-1.5	-1.2	-1.7	-1.7	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.7	-1.3	-0.5	-0.5	-1.1	1.2	1.0	-0.5	-0.5	0.0	-0.6	-1.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.0	-1.4	-1.4	-1.4	-1.2	0.7	0.5	-0.2	-0.1	0.0	-0.3	-1.1
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.3	0.7	0.9	0.1	-0.0	-0.5	0.5	0.9	0.4	0.5	0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.8	0.4	-0.1	0.0	0.2	1.3	-0.4	1.2	1.1	0.8	0.7	0.0
Angina	1.5	1.9	7.4	-1.3	-2.0	-2.7	-1.1	-1.0	1.6	-0.0	-0.4	-0.2	0.7	-1.6
Medication for hormone replacement therapy	0.4	0.5	1.5	-0.7	-0.9	-0.9	-0.6	1.2	-0.5	0.6	0.4	0.2	0.3	-0.7
Vitamin and mineral supplements	0.3	0.4	2.0	0.2	0.8	-0.1	0.4	0.3	-0.8	0.7	0.6	1.4	0.3	0.3
Supplements: Zinc	0.4	0.4	1.8	0.4	-0.3	0.9	0.5	1.3	-0.3	0.6	0.7	0.1	0.8	0.3
Medication: Co-codamol	0.5	0.6	2.1	0.0	-1.2	-0.7	0.4	1.4	0.7	0.6	0.8	0.5	1.0	0.1
Medication: Metformin	0.1	0.2	0.5	-0.3	-0.3	0.0	-0.6	0.7	0.3	0.2	0.2	-0.3	0.2	-0.7
Diabetes (father)	0.9	1.1	3.1	1.2	0.3	0.7	1.0	1.4	-0.7	1.2	0.9	0.7	1.7	0.9
Diabetes (mother)	0.2	0.3	1.1	-0.8	-0.2	-1.0	-0.7	-0.1	0.2	0.0	0.1	0.3	0.1	-0.8
Severe depression (siblings)	0.1	0.1	0.5	0.1	-0.1	0.0	-0.1	-0.1	-0.7	0.1	0.1	-0.3	-0.1	0.2
Pack years adult smoking proportion	0.1	0.1	0.5	0.2	-0.1	-0.1	0.0	0.7	-0.6	-0.4	-0.2	-0.6	-0.3	0.1
Impedance of leg (right)	0.4	1.7	5.5	1.3	-0.8	0.8	1.4	2.0	0.0	1.2	1.1	0.4	2.4	1.2
Leg fat-free mass (left)	0.3	1.4	4.8	-1.6	0.1	-1.4	-1.3	-1.1	-0.1	-0.8	-0.5	-0.0	-2.2	-1.4
Trunk fat percentage	0.2	0.8	2.9	-1.3	-1.7	-1.1	-0.6	-0.2	0.4	0.6	0.7	0.9	0.3	-0.9
Hand grip strength (right)	0.5	1.3	4.3	0.0	0.8	0.2	-0.5	-1.4	-0.1	-1.3	-1.3	-2.1	-1.9	-0.1
Townsend deprivation index at recruitment	0.2	0.3	1.2	0.5	0.1	0.8	0.3	-0.5	-0.9	0.1	-0.2	-1.1	0.4	0.4
Current tobacco smoking	2.5	4.2	8.0	2.2	1.7	2.1	2.3	0.3	-2.8	2.1	2.0	1.6	2.0	2.3
Average weekly fortified wine intake	1.5	1.7	6.4	0.9	1.7	2.5	0.3	-0.4	0.1	-1.3	-1.6	-1.0	-1.6	0.8
Maternal smoking around birth	0.4	0.6	1.7	-0.9	-0.5	0.0	-1.1	-0.6	-0.5	-0.8	-0.7	-0.7	-1.3	-0.9
Fed-up feelings	0.5	0.9	3.3	-0.5	-1.8	-1.2	0.2	1.5	-0.7	0.7	1.1	-0.2	0.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.1	-0.6	-0.1	-0.8	-0.4	0.2	-0.3	-0.5	-0.1	-1.1	-0.8	-0.6
Relative age voice broke	0.6	0.9	2.6	-0.4	0.3	-0.0	-0.8	-1.6	0.8	-1.3	-1.5	-1.0	-0.9	-0.5
Taking other prescription medications	0.6	1.0	2.6	-1.2	-1.0	-0.6	-1.1	-0.5	0.4	-0.9	-0.7	-1.2	-1.6	-0.9
Age when periods started (menarche)	0.5	1.3	4.3	-0.9	-0.7	-0.5	-1.3	-0.5	1.0	-1.2	-1.2	-2.1	-1.0	-1.0
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	8.2	-1.1	-2.1	-2.9	-0.5	2.1	-0.1	1.8	1.9	1.9	2.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.2	-1.6	-0.2	0.1	-1.4	-2.3	1.1	-2.2	-1.6	-1.1	-1.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	-0.6	0.2	-0.1	-0.9	-0.4	0.6	-0.8	-1.0	-1.0	-0.9	-0.5
Qualifications: CSEs or equivalent	0.8	1.1	2.4	-1.4	-1.4	-1.5	-1.5	-1.1	0.1	0.3	0.0	-0.0	0.3	-1.5
Serious illness, injury or assault to yourself	0.3	0.3	1.1	-0.8	0.6	-0.1	-0.8	0.1	-0.2	-0.2	0.1	0.4	-1.1	-0.7
High blood pressure	0.5	1.3	3.7	-1.3	-1.9	-1.3	-1.2	0.2	1.4	-0.7	-0.5	-0.6	-0.6	-1.3
Hayfever, allergic rhinitis or eczema	0.9	2.1	6.2	-0.5	0.9	0.2	-0.5	-1.4	1.0	-2.5	-2.1	-1.7	-2.1	-0.1
Multivitamins +/- minerals	0.5	0.7	1.8	-0.6	-1.3	-0.9	-0.6	-0.5	1.0	-0.7	-0.5	-1.2	-0.1	-0.7
Stomach or abdominal pain in last month	2.3	2.8	6.8	-0.4	1.7	0.8	-0.9	-2.0	0.8	-2.3	-2.2	-2.1	-2.6	-0.4
Supplements: Glucosamine	0.1	0.2	0.6	-0.3	-0.8	-0.1	-0.2	-0.1	0.8	-0.1	-0.2	-0.1	0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	6.2	-1.8	0.0	-0.7	-1.9	-1.5	1.8	-1.7	-1.8	-2.5	-2.0	-1.9
Medication: Atenolol	1.2	1.5	8.9	-0.4	-1.8	-3.0	-0.3	-0.4	1.6	0.5	0.4	0.3	1.1	-0.6
Medication: Levothyroxine sodium	2.6	4.5	7.5	-2.1	-1.8	-0.7	-2.1	-1.5	2.4	-2.6	-2.7	-2.7	-1.7	-2.1
Sitting height	0.3	1.9	6.8	-1.8	0.4	-0.8	-1.4	-0.5	-0.2	-1.8	-1.3	-0.6	-2.6	-1.4
Chronic bronchitis/emphysema (father)	1.5	1.8	5.4	-2.2	-0.7	-1.2	-2.0	-0.3	1.1	-0.9	-0.9	-0.7	-0.6	-2.3
High blood pressure (mother)	1.6	2.3	5.0	1.7	-0.5	0.4	1.9	0.4	-1.6	1.9	2.2	1.1	1.6	1.7
Body mass index (BMI)	0.3	1.4	2.9	-1.7	-1.0	-1.5	-1.6	-1.3	0.5	-0.5	-0.3	-0.2	-1.4	-1.7
Impedance of leg (left)	0.4	2.1	7.2	1.3	-1.0	0.7	1.5	1.8	-0.2	1.5	1.4	1.0	2.7	1.3
Leg predicted mass (left)	0.2	1.2	4.6	-1.4	0.2	-1.3	-1.2	-1.1	-0.2	-0.8	-0.5	-0.0	-2.1	-1.3
Trunk fat mass	0.2	0.8	2.1	-1.5	-1.4	-1.2	-0.9	-0.3	0.0	0.4	0.5	0.7	-0.3	-1.2
Waist circumference	0.5	1.8	4.2	-2.1	-0.9	-1.3	-1.9	-1.1	0.7	-0.7	-0.5	-0.4	-1.6	-2.0
Number of incorrect matches in round	0.1	0.2	1.3	0.1	0.3	-0.5	0.1	1.1	-0.7	0.2	0.0	-0.2	-0.2	0.1
Past tobacco smoking	1.0	1.8	4.4	1.1	0.0	1.0	0.9	1.4	-2.1	1.7	1.8	0.8	1.6	1.0
Alcohol usually taken with meals	0.9	1.5	3.6	-0.4	1.1	0.7	-0.7	-1.0	0.8	-1.9	-1.9	-1.5	-1.6	-0.4
Nervous feelings	0.5	1.0	2.6	0.5	0.1	-0.2	1.0	0.1	-1.1	1.1	1.5	1.6	1.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.3	-0.1	-0.5	0.4	1.0	-0.6	0.3	0.8	-0.1	0.3	0.1
Hearing difficulty/problems with background noise	0.5	0.8	2.3	-0.4	0.1	0.8	-0.1	-1.2	0.6	-1.2	-1.1	-0.8	-1.5	0.0
Hair/balding pattern: Pattern 2	0.1	0.2	1.3	0.4	-0.0	0.0	0.4	-1.1	-0.4	-0.2	-0.0	0.1	0.1	0.5
Had menopause	0.4	0.5	1.5	-0.2	-0.1	-0.3	-0.3	0.9	-0.5	1.0	0.9	1.2	0.6	-0.1
Had other major operations	0.1	0.1	0.7	0.1	0.1	0.9	0.1	0.5	-0.1	0.7	0.3	0.2	-0.0	0.0
Forced vital capacity (FVC)	0.2	0.8	2.5	1.6	0.1	0.1	1.3	0.7	-0.8	0.8	0.7	0.2	0.9	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.0	-1.5	0.1	0.5	-1.4	-1.5	1.0	-2.0	-1.5	-1.0	-1.9	-1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	0.5	-0.3	-0.9	0.6	0.5	-0.0	0.3	0.7	-0.2	-0.0	0.5
Qualifications: None of the above	0.5	1.1	6.6	0.1	0.4	0.6	-0.1	2.6	0.2	1.1	0.9	1.2	1.1	-0.1
Financial difficulties in last 2 years	0.9	1.2	3.6	-1.1	-0.3	0.2	-0.9	-0.3	0.2	-1.4	-1.4	-1.5	-1.9	-1.0
Mouth/teeth dental problems	1.1	1.6	3.4	-1.4	-0.7	-0.8	-1.8	-0.8	0.9	-1.7	-1.3	-0.2	-1.5	-1.7
Heart attack	0.9	1.1	2.6	0.5	-0.2	-0.5	0.9	0.9	-1.0	1.4	1.4	1.6	1.6	0.4
Allergy	0.3	0.6	2.4	0.4	-0.5	-0.2	0.1	0.6	0.2	1.6	1.3	1.0	1.1	-0.2
Pain all over the body in last month	0.4	0.4	2.2	-0.1	-0.1	0.2	0.4	1.5	-0.9	0.5	0.7	0.9	0.4	0.1
Diabetes (self-reported)	0.3	0.5	1.6	-1.1	-0.2	-0.7	-1.2	0.2	0.8	-0.1	-0.1	-0.5	-0.4	-1.3
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	7.5	0.4	2.7	1.8	-0.7	-1.1	-0.1	-2.2	-2.1	-1.2	-2.7	0.4
Medication: Ramipril	0.9	1.1	2.5	-1.5	-0.9	-1.2	-1.4	0.1	1.5	-0.6	-0.6	-0.2	-0.7	-1.6
Medication: Simvastatin	2.3	3.4	6.4	-1.1	0.5	-1.1	-1.5	-2.5	1.8	-2.5	-2.5	-1.6	-2.4	-1.4
Fluid intelligence score	0.4	0.8	4.8	-0.2	0.1	-0.1	-0.6	-2.2	-0.0	-1.0	-1.1	-1.2	-0.5	-0.2
Illnesses of siblings	1.0	1.3	4.1	1.2	2.0	1.2	1.0	0.2	-2.0	0.5	0.5	0.4	0.2	1.4
Neuroticism score	0.6	1.3	3.7	0.7	-0.3	-0.2	1.3	0.9	-1.6	1.6	1.9	0.7	1.0	1.0
Weight	0.3	1.4	3.5	-1.9	-0.8	-1.6	-1.5	-0.8	-0.1	-0.5	-0.2	0.0	-1.7	-1.7
Impedance of arm (right)	0.2	0.8	4.1	0.3	-0.8	0.4	0.8	1.1	0.5	0.8	0.6	0.7	2.0	0.6
Arm fat percentage (right)	0.2	0.9	2.5	-1.6	-1.4	-1.2	-1.1	-0.4	0.7	-0.0	0.1	0.4	-0.4	-1.4
Trunk fat-free mass	0.2	1.0	5.1	-1.0	0.7	-0.9	-0.9	-0.7	-1.1	-0.6	-0.3	-0.1	-2.2	-1.0
Hip circumference	0.1	0.4	1.4	-0.4	0.1	-0.4	-0.1	0.1	-1.1	0.8	1.0	1.2	-0.2	-0.3
Time employed in main current job	1.6	1.8	4.7	-0.7	0.8	0.4	-1.3	-0.9	1.6	-1.7	-1.8	-1.5	-2.2	-1.0
Alcohol intake versus 10 years previously	0.2	0.2	0.8	-0.2	-0.4	-0.9	-0.3	-0.7	0.4	0.2	0.1	0.3	0.7	-0.6
Father’s age at death	0.2	0.3	1.8	0.4	1.3	0.6	0.3	0.1	0.3	-0.2	-0.1	0.2	-0.6	0.5
Worrier / anxious feelings	0.1	0.1	0.4	0.1	-0.0	-0.4	0.4	-0.5	0.4	-0.2	-0.3	-0.6	-0.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	9.1	-2.2	0.2	-0.2	-1.8	-0.2	1.5	-2.4	-2.1	-2.0	-3.0	-1.7
Falls in the last year	2.0	2.7	6.3	-1.3	0.2	0.2	-1.6	-1.2	1.2	-2.3	-2.2	-2.0	-2.5	-1.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.1	-0.0	-0.5	0.2	-0.2	0.4	0.3	0.4	0.2	0.1	-0.1
Number of live births	0.1	0.2	0.7	0.3	0.9	0.5	0.3	0.2	-0.0	0.2	-0.0	-0.6	-0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.4	1.2	0.1	-0.1	0.8	-0.1	-0.7	0.2	0.3	-0.5	0.2	0.9
Pulse rate	0.1	0.3	0.8	-0.5	-0.9	0.0	-0.1	0.7	0.7	-0.5	-0.6	-0.1	-0.2	-0.3
Happiness	0.5	0.6	1.9	0.7	1.0	0.7	0.7	-1.1	-0.0	-0.8	-0.5	-1.4	-0.4	0.4
Noisy workplace	2.3	2.8	8.7	-0.3	-2.7	-1.9	0.5	1.7	1.0	1.8	1.5	1.2	2.9	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.9	0.6	1.5	1.3	0.5	-1.7	0.3	-0.9	-0.8	-0.8	-0.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	6.2	-1.4	-2.5	-1.3	-1.0	-1.3	1.4	-1.3	-1.0	-1.8	-0.9	-1.2
Mouth/teeth dental problems: Dentures	4.9	8.3	14.5	3.5	2.6	1.8	3.8	1.6	-2.1	3.3	2.9	2.5	2.9	3.7
Asthma	1.4	2.7	5.2	-1.8	-0.1	-0.3	-1.8	-0.9	1.1	-2.3	-2.2	-2.0	-2.2	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.2	-1.8	-1.1	-1.2	-1.6	-0.6	1.1	-1.0	-1.1	-1.2	-1.0	-1.6
Medication: Cholesterol lowering	1.4	2.2	7.6	-1.6	-2.1	-2.8	-1.7	-0.4	1.3	-0.5	-0.7	-0.2	-0.4	-1.9
Depression (self-reported)	0.7	0.8	1.4	1.1	0.6	1.1	1.1	0.9	-1.1	1.0	0.9	0.2	0.1	1.2
Medication: Lansoprazole	0.4	0.4	1.5	-0.3	1.2	0.7	-0.1	0.1	-0.7	-0.6	-0.5	-0.5	-1.0	-0.1
Prospective memory result	0.3	0.3	1.0	-0.6	0.4	-0.7	-0.2	-1.0	1.0	-0.4	-0.4	-0.3	-0.0	-0.4
Lung cancer (father)	0.3	0.4	1.2	-1.1	-1.0	0.1	-0.7	0.6	-0.3	0.2	-0.1	0.3	0.1	-0.9
Illnesses of mother	0.2	0.3	0.8	0.7	0.7	0.6	0.9	0.4	-0.5	0.2	-0.1	0.1	0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	2.2	0.5	0.1	-0.2	0.1	-0.6	0.2	-0.7	-0.7	-1.5	-0.6	0.3
Pulse wave Arterial Stiffness index	2.4	2.8	5.6	-2.4	-1.5	-0.9	-2.0	-0.3	1.4	-1.9	-1.9	-1.5	-1.4	-2.1
Impedance of arm (left)	0.1	0.7	3.5	0.2	-1.0	0.5	0.6	0.9	0.8	0.6	0.3	0.4	1.9	0.5
Arm fat mass (right)	0.2	0.8	2.4	-1.5	-0.6	-0.9	-1.2	-0.9	0.2	-0.3	-0.1	0.2	-1.1	-1.4
Trunk predicted mass	0.2	0.9	4.7	-0.9	0.8	-0.9	-0.8	-0.7	-1.1	-0.5	-0.2	-0.0	-2.2	-0.9
Standing height	0.0	0.3	1.9	-0.4	0.4	-0.4	0.1	0.6	-1.4	-0.1	0.2	0.5	-0.9	-0.1
Length of working week for main job	0.1	0.1	0.7	-0.2	-0.1	-0.4	0.2	0.8	-0.1	0.1	0.3	-0.3	0.3	-0.2
Exposure to tobacco smoke at home	1.5	1.7	4.4	1.2	0.5	0.6	1.3	0.9	-1.3	1.8	1.7	0.8	2.1	1.1
Breastfed as a baby	2.4	2.9	6.2	-2.4	-0.2	-0.2	-2.5	-0.5	1.9	-1.9	-1.9	-0.7	-2.1	-2.1
Tense / ‘highly strung’	0.5	0.9	2.8	1.2	0.5	0.9	1.7	0.5	-0.4	0.6	0.7	0.1	0.8	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.4	-0.1	0.1	0.7	0.9	-0.9	1.0	1.0	0.3	0.5	0.6
Hair/balding pattern: Pattern 4	0.6	1.5	3.3	-1.6	-0.1	-1.1	-1.7	-0.6	0.9	-1.2	-1.1	-1.3	-0.9	-1.8
Birth weight of first child	1.1	2.0	4.0	-1.9	0.2	-0.6	-1.9	-1.2	0.4	-1.5	-1.3	-1.4	-2.0	-1.8
Peak expiratory flow (PEF)	1.1	2.6	5.6	2.4	1.2	1.0	2.2	0.5	-1.9	1.2	1.4	1.3	1.2	2.3
Pulse wave reflection index	3.7	4.5	6.8	-2.5	-1.0	-1.0	-2.6	-1.4	1.8	-2.4	-2.5	-2.5	-2.3	-2.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.7	0.5	-0.3	-1.3	0.5	-0.2	-0.5	0.3	0.5	-0.2	0.1	0.5
Loud music exposure frequency	0.3	0.3	1.2	-0.2	-0.7	-0.0	0.4	-0.7	1.1	-0.4	-0.4	-0.6	-0.3	0.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	7.5	0.1	-0.2	-0.4	-0.1	-2.7	-0.6	-0.1	-0.1	-0.6	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	3.6	1.7	0.1	0.6	1.9	-0.3	-1.3	1.4	1.3	0.6	1.6	1.7
Blood clot in the leg (DVT)	2.5	3.2	5.9	1.9	1.1	1.6	2.4	1.2	-2.1	1.6	1.7	1.5	1.9	2.4
Medication: Paracetamol	0.2	0.3	0.6	0.8	-0.1	0.4	0.8	0.4	-0.8	0.5	0.4	-0.3	-0.0	0.8
Headache pain in last month	1.8	3.1	6.1	2.4	1.9	1.8	2.3	1.2	-2.1	1.3	1.1	0.9	1.0	2.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	8.5	1.6	2.6	2.9	1.6	-0.0	-0.9	0.3	0.1	0.0	0.4	1.7
Glaucoma (self-reported)	3.9	4.6	9.8	-2.9	-1.7	-1.3	-2.9	-0.3	2.0	-2.1	-2.1	-1.9	-1.8	-3.1
Gout (self-reported)	0.5	0.7	4.8	-0.9	-2.2	-0.7	-0.6	-0.1	0.3	-0.2	0.0	-0.4	0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.8	-1.1	-0.8	-0.3	-1.3	-1.2	1.5	-1.9	-1.9	-2.2	-1.2	-1.3
Medication: Amlodipine	0.5	0.7	2.4	-0.7	-1.6	-1.2	-0.3	0.8	0.6	0.7	0.6	0.5	0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.8	-1.7	-0.3	-1.2	-1.5	-0.2	0.4	-0.8	-0.6	-0.4	-0.7	-1.6
Birth weight	0.3	0.7	2.0	1.1	0.7	-0.6	1.4	-0.0	-0.8	0.7	0.9	0.5	0.5	1.2
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.9	0.7	-0.2	0.4	0.8	1.0	-0.2	0.3	0.3	0.3	0.6	0.5
High blood pressure (siblings)	0.9	1.2	4.8	-0.9	-1.6	-1.4	-0.8	-0.9	2.2	-0.3	-0.4	-0.6	-0.2	-1.2
Forced vital capacity (FVC), Best measure	0.1	0.4	1.4	1.2	0.2	0.0	1.0	0.4	-0.1	0.2	0.1	-0.3	0.3	1.1
Body fat percentage	0.2	0.8	2.9	-1.2	-1.7	-1.1	-0.7	0.1	0.3	0.6	0.8	0.9	0.3	-0.9
Leg fat percentage (right)	0.3	0.9	4.0	-1.2	-2.0	-1.2	-0.8	0.6	0.6	0.4	0.6	0.5	0.2	-1.2
Arm fat-free mass (right)	0.1	0.6	2.8	-0.6	0.7	-0.7	-0.5	-0.9	-1.3	-0.1	0.2	0.3	-1.7	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	2.5	1.3	0.5	1.6	1.2	-0.0	-0.9	0.4	0.2	-0.8	0.6	1.0
Comparative body size at age 10	0.1	0.4	1.1	-0.4	-0.4	-1.1	-0.5	0.8	-0.6	0.5	0.7	0.3	-0.1	-0.5
Number of full brothers	1.0	1.3	2.9	-1.6	0.2	-0.7	-1.4	-0.9	1.2	-1.0	-1.0	-0.9	-1.0	-1.7
Worry too long after embarrassment	0.5	0.8	2.7	-1.3	-1.5	-1.6	-0.7	0.4	0.4	-0.1	0.0	-0.4	-0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.9	-0.7	0.5	0.5	-0.6	-0.2	0.5	-0.9	-0.9	-0.7	-1.4	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.7	-0.5	-0.4	-0.5	-0.2	-0.1	-0.3	-0.4	-0.7	-0.3	-0.5
Number of children fathered	1.3	1.4	4.5	-2.1	-0.8	-1.5	-1.7	-0.2	1.0	-0.2	-0.2	0.5	-0.4	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	6.7	-0.5	0.8	0.0	-0.5	-1.1	0.5	-1.3	-1.0	-0.9	-2.6	-0.3
Age at first live birth	0.5	0.9	4.4	0.6	2.1	1.5	0.3	-0.8	-0.8	-0.4	-0.4	-0.2	-0.8	0.7
Pulse wave peak to peak time	2.0	2.3	4.6	2.1	1.3	0.6	1.8	0.2	-1.4	1.8	1.8	1.4	1.3	1.9
Health satisfaction	0.5	0.7	1.5	0.3	0.7	1.2	0.5	-1.1	-0.5	-1.1	-0.5	-1.2	-0.9	0.4
Shortness of breath walking on level ground	0.1	0.1	0.7	-0.1	-0.2	-0.3	0.2	0.1	-0.8	0.5	0.6	0.3	0.0	-0.1
Qualifications: College or University degree	0.7	2.2	5.4	-0.8	0.5	0.4	-0.9	-1.8	1.4	-2.3	-2.3	-1.5	-1.9	-0.7
Eye problems/disorders: None of the above	0.1	0.1	0.6	-0.1	-0.8	0.2	-0.1	-0.1	0.3	0.1	0.2	0.5	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	2.0	2.4	5.8	-1.4	-0.7	-0.2	-1.4	-2.4	1.0	-1.8	-2.0	-2.2	-1.2	-1.3
Emphysema/chronic bronchitis	1.0	1.1	2.4	1.3	0.3	0.1	1.6	-0.3	-1.1	0.9	1.0	1.3	1.4	1.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.3	0.8	1.1	1.0	0.5	-0.1	-0.8	0.4	0.4	0.9	0.9	0.8
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.2	0.1	-0.4	-0.4	-0.5	-0.7	0.2	0.3	0.4	0.2	-0.6
Medication: Blood pressure	1.1	2.0	6.8	-1.4	-2.4	-2.6	-1.2	1.2	0.4	0.8	0.9	0.6	0.6	-1.5
Angina (self-reported)	1.5	1.9	7.8	-1.1	-2.1	-2.8	-0.8	-0.8	1.6	0.3	-0.1	0.1	1.3	-1.5
Migraine (self-reported)	1.8	2.2	6.7	-1.7	-0.1	0.3	-1.8	0.1	2.6	-1.4	-2.1	-1.1	-1.3	-1.6
Medication: Ibuprofen	0.7	0.9	1.8	-1.4	-0.9	-1.0	-1.2	-0.5	1.0	-0.6	-0.7	-0.9	-0.4	-1.2
Medication: Allopurinol	0.2	0.3	1.2	0.1	-1.1	-0.1	0.4	0.2	-0.5	0.3	0.7	0.5	0.7	0.1
Medication: Omeprazole	0.5	0.6	1.6	-1.1	-1.0	-0.3	-1.3	-0.2	-0.0	-0.6	-0.4	-0.6	-1.1	-1.0
Medication: Seretide 50 evohaler	0.5	0.5	1.5	0.4	0.4	1.1	0.5	1.2	-1.2	0.6	0.5	0.1	0.3	0.5
Mean time to correctly identify matches	1.2	2.2	4.8	1.6	-0.0	0.9	2.2	0.3	-1.1	1.8	1.6	1.3	1.9	1.9
Heart disease (mother)	0.1	0.1	0.4	-0.3	0.2	-0.0	-0.1	-0.0	-0.2	0.5	0.5	0.7	0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.1	-1.5	-1.1	-1.4	-1.4	-0.1	0.1	-0.3	-0.2	-0.6	-1.1	-1.4
Whole body fat mass	0.1	0.6	1.5	-1.2	-1.0	-1.0	-0.9	-0.5	-0.0	0.2	0.4	0.6	-0.6	-1.0
Leg fat mass (right)	0.2	0.8	2.1	-1.4	-1.5	-1.2	-1.1	-0.0	0.3	0.1	0.3	0.4	-0.7	-1.3
Arm predicted mass (right)	0.1	0.6	2.1	-0.3	0.7	-0.8	-0.3	-0.7	-1.4	0.1	0.4	0.6	-1.4	-0.4
Pulse rate, automated reading	0.3	0.8	1.9	1.1	-0.5	0.5	1.4	0.7	-0.8	0.8	1.2	0.4	0.5	1.3
Alcohol intake frequency.	1.0	2.4	5.5	1.0	0.1	-0.4	1.6	0.7	-2.1	2.1	2.3	1.7	2.0	1.0
Comparative height size at age 10	0.4	2.0	4.4	-0.4	-0.6	-1.1	0.1	1.9	-2.1	1.8	1.9	2.0	0.9	-0.1
Number of full sisters	0.8	0.9	2.6	-1.5	-1.6	-0.9	-1.0	1.1	0.3	-0.2	0.0	-0.4	-0.1	-1.4
Suffer from ‘nerves’	0.3	0.5	1.6	-0.4	0.8	0.5	-0.4	-1.3	-0.3	-0.8	-0.5	-0.9	-0.6	-0.2
Overall health rating	0.3	0.7	1.6	-1.0	-0.3	0.4	-0.9	0.5	0.2	-0.7	-0.6	-1.1	-1.2	-1.0
Chest pain or discomfort	0.8	1.1	2.6	-0.1	-1.3	-1.5	0.6	1.0	-0.6	1.2	1.4	0.7	1.6	-0.0
Had major operations	0.9	1.1	4.2	-0.4	-2.0	-1.0	-0.1	1.8	-0.6	0.9	0.9	0.6	0.8	-0.3
Age at last live birth	0.4	0.5	1.6	0.1	1.3	1.1	0.4	-0.7	-1.1	0.3	0.5	0.6	0.1	0.4
Family relationship satisfaction	1.6	2.0	5.6	1.7	2.4	2.1	1.5	-1.2	-1.1	-0.3	-0.4	0.1	-0.5	1.8
Leg pain on walking	0.5	0.6	2.5	-0.5	0.4	0.8	-0.4	-1.6	0.4	-0.9	-0.8	-0.4	-0.8	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.9	-0.4	-0.4	-0.8	-0.9	-1.3	0.7	-1.3	-1.2	-2.2	-1.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.4	0.2	1.0	0.6	-0.2	-1.2	0.4	-0.9	-0.9	-0.6	-1.6	-0.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.6	2.1	1.5	1.2	1.7	0.2	-0.8	1.7	1.2	1.2	1.9	2.0
Medication: Aspirin	0.9	1.2	3.7	-1.2	-0.3	-1.9	-1.1	-0.9	1.2	-1.0	-0.8	-0.4	-0.9	-1.3
Supplements: Vitamin C	0.3	0.4	2.5	0.4	0.6	1.6	0.1	0.4	0.0	0.1	-0.1	-0.7	0.0	0.5
Knee pain experienced in last month	0.1	0.1	0.9	-0.4	-0.1	0.3	-0.1	-0.4	-0.1	0.4	0.2	0.9	0.1	-0.2
Hypertension (Self-reported)	0.6	1.6	2.8	-1.5	-1.6	-1.2	-1.4	-0.3	1.7	-1.1	-0.9	-1.0	-1.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	-0.1	-0.4	-0.7	0.2	0.1	-0.3	-0.5	-0.4	-1.1	-1.1	0.1
Illnesses of father: Heart disease	1.2	1.7	5.0	1.9	0.6	0.2	1.9	-0.5	-2.0	0.5	0.9	0.6	0.3	2.2
Illnesses of siblings: Diabetes	2.7	3.3	9.0	-2.5	-2.1	-2.0	-1.9	-0.5	3.0	-1.1	-1.2	-0.0	-0.7	-2.4
Smoking status: Previous	2.3	3.4	7.4	-1.6	-0.8	-2.1	-1.6	-1.3	2.7	-2.1	-2.2	-1.5	-2.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.1	1.1	-0.2	-0.4	1.2	1.0	-0.6	1.4	0.9	-0.3	1.4	0.9
Whole body fat-free mass	0.2	1.0	4.7	-1.1	0.5	-1.1	-0.9	-0.9	-0.9	-0.6	-0.3	0.0	-2.2	-1.0
Leg fat-free mass (right)	0.2	1.2	4.1	-1.4	0.3	-1.3	-1.1	-1.4	-0.3	-0.8	-0.4	0.2	-2.0	-1.3
Arm fat percentage (left)	0.2	0.8	2.1	-1.4	-1.4	-1.1	-1.0	-0.4	0.6	0.1	0.2	0.5	-0.2	-1.2
Average weekly red wine intake	1.0	1.5	3.1	-1.0	0.4	-0.4	-1.3	-1.2	0.7	-1.8	-1.7	-1.5	-1.8	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.6	0.7	-0.0	0.5	-0.0	0.9	-0.5	-0.4	-0.3	0.3	0.4
Mood swings	0.6	1.1	3.6	0.8	-0.1	0.4	1.2	1.9	-0.9	1.1	1.4	0.8	0.7	1.0
Loneliness, isolation	0.9	1.2	4.6	0.6	0.8	0.5	0.9	0.5	-2.1	1.4	1.7	0.6	0.5	0.8
Long-standing illness, disability or infirmity	1.8	2.8	4.9	-2.0	0.1	0.1	-2.2	-1.4	0.6	-2.2	-1.9	-1.8	-2.2	-1.7
Ever had bowel cancer screening	0.3	0.3	1.2	-0.1	0.8	1.1	-0.2	-0.6	0.5	-0.7	-0.6	-0.3	-0.5	0.0
Diabetes diagnosed by doctor	0.3	0.4	0.8	-0.7	0.6	-0.0	-0.9	0.2	0.7	-0.5	-0.5	-0.8	-0.8	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	-0.7	0.5	-0.6	-0.8	-0.3	0.1	-0.7	-0.7	-0.5	-0.7	-0.6
Friendships satisfaction	0.9	1.1	4.2	1.4	2.1	1.3	0.9	-0.2	-1.3	-0.1	-0.1	-0.7	-0.5	1.1
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.6	-1.0	-0.7	-0.0	-0.1	0.3	-0.9	-0.6	-0.0	-0.6	-0.2
Commuting to job workplace: Walk	0.5	0.6	1.6	0.1	0.6	1.2	0.1	-0.6	1.1	-0.5	-0.9	-1.2	-0.1	0.3
Eye problems/disorders: Cataract	0.3	0.3	2.2	0.0	0.0	-1.5	0.3	-0.4	-0.3	0.2	0.4	0.3	1.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.0	-1.3	0.3	-0.5	-1.1	-0.6	0.7	-1.4	-1.4	-1.3	-0.7	-0.9
Medication for cholesterol	0.4	0.6	1.3	0.5	0.4	0.4	0.6	1.0	-0.8	1.1	1.1	0.7	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	6.9	-2.6	-1.2	-1.3	-2.6	-2.0	1.6	-2.1	-2.1	-1.2	-1.6	-2.6
Back pain experienced in last month	0.3	0.4	1.3	-0.9	-0.5	0.3	-0.9	-0.1	0.2	-0.5	-0.7	0.0	-1.1	-0.8
Mineral and other dietary supplements	0.2	0.3	0.8	0.6	0.7	0.3	0.4	0.3	-0.9	0.4	0.4	0.3	-0.4	0.6
Breast cancer (self-reported)	3.8	4.5	10.3	1.5	-1.1	-0.1	1.6	1.0	-2.3	3.2	3.0	2.4	3.0	1.5
Asthma (self-reported)	1.4	2.8	5.7	-1.8	0.0	-0.2	-1.8	-0.7	1.0	-2.3	-2.2	-2.0	-2.4	-1.7
Osteoporosis (self-reported)	0.6	0.7	1.7	0.7	-0.2	-0.1	0.5	1.2	-0.7	1.2	0.9	1.0	1.3	0.6
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.1	-0.1	-0.3	0.6	0.6	0.6	0.3	-0.3
Medication: Aspirin	1.1	1.4	4.2	-1.4	-0.5	-2.0	-1.2	-0.9	1.4	-0.9	-0.8	-0.5	-0.8	-1.5
Medication: Gliclazide	0.4	0.4	1.2	-0.4	-1.0	-0.8	-0.1	1.1	0.8	0.6	0.6	0.5	0.6	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	-1.3	-0.5	-0.1	-1.4	-0.8	0.9	-0.5	-0.6	-0.1	-0.6	-1.4
Smoking status: Current	2.9	4.6	7.3	2.3	1.6	2.1	2.5	0.5	-2.7	2.2	2.2	1.9	2.3	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.6	-0.5	-0.5	0.1	-0.0	-0.5	0.3	0.3	-0.0	0.3	0.4
Whole body water mass	0.2	1.1	5.0	-1.1	0.6	-1.1	-1.0	-1.0	-0.9	-0.6	-0.3	0.0	-2.2	-1.1
Leg predicted mass (right)	0.3	1.4	4.6	-1.5	0.2	-1.3	-1.2	-1.4	-0.2	-0.8	-0.5	0.1	-2.2	-1.4
Arm fat mass (left)	0.2	0.8	2.2	-1.5	-0.8	-1.1	-1.1	-0.9	0.1	-0.2	0.0	0.3	-1.0	-1.3
Number of self-reported non-cancer illnesses	2.2	3.8	10.0	-1.4	0.5	0.9	-1.8	-1.2	-0.0	-2.7	-2.4	-3.1	-3.2	-1.2
Average weekly champagne plus white wine intake	0.6	0.8	3.0	0.8	1.7	1.6	0.6	-0.3	-0.2	-0.4	-0.3	0.2	-0.7	0.9
Miserableness	0.7	1.2	4.0	0.8	-1.3	-0.4	1.3	2.0	-0.4	1.1	1.3	0.6	0.8	1.1
Guilty feelings	0.4	0.6	2.9	-0.9	-0.9	-1.7	-0.5	-0.7	-0.4	0.0	0.2	-0.6	0.1	-0.7
Wears glasses or contact lenses	0.3	0.4	1.4	0.3	1.2	0.6	0.1	-0.3	-0.3	-0.9	-0.6	-0.4	-0.9	0.3
Ever taken oral contraceptive pill	0.9	1.0	1.7	-1.3	-1.0	-0.7	-1.1	0.0	1.3	-0.9	-1.1	-0.8	-1.2	-1.2
Hearing aid user	0.2	0.2	0.4	-0.5	-0.0	0.1	-0.7	0.7	0.1	-0.6	-0.3	-0.1	-0.3	-0.6
Mother’s age at death	0.6	0.8	1.9	1.0	1.1	1.4	0.9	-0.8	-1.2	0.2	0.2	0.5	0.4	1.1
Financial situation satisfaction	0.4	0.5	1.3	0.9	1.1	1.0	1.0	-0.4	-0.6	-0.0	0.0	-0.2	-0.1	0.8
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	-1.0	0.4	-0.8	-1.4	-0.9	0.3	-1.0	-0.7	-0.5	-1.3	-1.4
Commuting to job workplace: Public transport	0.6	0.7	4.7	-0.5	-2.2	-0.9	-0.2	1.1	0.7	0.1	0.1	-0.3	0.1	-0.4
Eye problems/disorders: Glaucoma	1.6	2.0	3.7	-1.6	-0.7	-0.7	-1.7	-0.6	1.2	-1.6	-1.5	-1.9	-1.2	-1.9
Medication: Blood pressure	0.1	0.1	0.4	0.4	-0.3	0.6	0.4	-0.5	0.4	-0.3	-0.2	-0.3	0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.3	1.1	0.2	-0.0	1.4	0.8	-0.6	1.2	1.5	1.3	1.0	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.8	-1.1	-1.9	-1.4	-1.0	0.1	1.9	-0.7	-0.6	-0.4	0.3	-1.3
High cholesterol (Self-reported)	2.3	4.1	8.9	-1.3	-0.6	-1.0	-1.7	-2.2	2.2	-3.0	-3.0	-2.1	-2.3	-1.5
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.4	-0.7	0.0	-0.5	0.5	0.2	-0.3	-0.2	-0.4	-0.8	-0.2
Medication: Paracetamol	0.1	0.2	0.4	0.4	-0.6	0.3	0.4	0.5	-0.2	0.1	0.2	-0.6	-0.5	0.4
Medication: Lisinopril	0.1	0.1	0.6	0.2	-0.0	0.8	-0.2	0.2	0.1	0.3	0.5	-0.0	0.4	-0.1
Medication: Atorvastatin	0.3	0.3	1.0	-0.7	-0.1	0.0	-0.9	0.1	0.9	-0.4	-0.3	-0.5	-0.1	-1.0
Illnesses of father: High blood pressure	4.5	5.6	9.1	3.0	1.0	1.4	3.0	1.3	-2.5	2.7	2.8	1.6	2.5	2.9
Alcohol drinker status: Never	0.3	0.4	2.0	0.1	-0.4	-1.1	0.1	-1.4	-0.2	0.2	0.2	-0.5	0.4	0.0
Ever smoked	0.3	0.4	1.6	-0.2	1.3	0.4	0.0	-1.2	0.2	-0.6	-0.6	0.1	-0.9	0.0
Basal metabolic rate	0.2	1.1	4.4	-1.2	0.3	-1.2	-1.0	-0.9	-0.6	-0.6	-0.2	0.0	-2.1	-1.2
Leg fat percentage (left)	0.3	1.0	4.2	-1.3	-2.1	-1.3	-0.9	0.1	0.6	0.4	0.6	0.8	0.2	-1.2
Arm fat-free mass (left)	0.1	0.8	3.7	-0.6	0.6	-0.9	-0.5	-0.7	-1.3	-0.3	0.2	0.4	-1.9	-0.6
Number of operations (self-reported)	0.6	0.8	4.0	-0.7	-1.3	-0.5	-0.3	2.0	-0.7	1.0	0.8	0.2	0.5	-0.6
Average weekly beer plus cider intake	0.5	0.8	2.1	-0.0	-0.2	0.9	-0.4	-0.8	0.2	-1.2	-1.4	-1.4	-1.1	-0.2
Irritability	0.5	0.8	2.0	1.2	0.7	1.1	1.4	-0.3	-0.8	0.6	0.7	0.5	0.1	1.3
Risk taking	1.6	2.3	6.0	-2.2	-0.7	-1.5	-2.5	0.4	1.2	-1.1	-1.2	-0.6	-1.1	-2.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.7	-0.4	-0.2	-0.0	-0.4	0.2	0.7	-0.8	-0.9	-1.1	-1.3	-0.2
Fractured/broken bones in last 5 years	1.3	1.7	3.4	1.4	1.2	1.6	1.4	1.0	-1.9	1.2	1.2	0.9	0.3	1.6
Age started oral contraceptive pill	0.6	0.8	1.5	-1.2	-1.2	-0.8	-1.1	1.0	0.5	-0.0	0.1	1.1	0.1	-1.1
Diastolic blood pressure, automated reading	0.2	0.5	1.9	0.6	-0.7	1.0	0.5	0.1	-0.9	0.8	1.4	0.4	0.4	0.5
Ever depressed for a whole week	0.3	0.3	1.2	-0.1	0.2	-0.5	-0.5	0.4	0.4	-0.9	-0.7	-0.6	-1.1	-0.3
Unable to work because of sickness or disability	1.3	1.7	4.5	-0.9	0.6	0.9	-0.8	-0.3	0.9	-1.7	-1.8	-2.1	-1.9	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.1	0.5	-0.1	-0.1	0.9	0.1	0.4	0.6	0.7	0.2	-0.2
Myopia	0.1	0.2	1.1	-0.1	0.4	0.7	-0.4	0.0	-1.0	0.3	0.2	0.2	0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.3	1.2	1.8	1.5	1.1	0.4	-1.1	0.5	0.3	0.5	0.6	1.3
Cholesterol lowering medication	2.6	3.9	9.0	-1.1	1.2	0.2	-1.5	-2.5	1.4	-3.0	-2.7	-2.2	-2.6	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	-1.0	-1.0	-0.4	-1.2	0.1	-0.1	-0.7	-0.4	-0.7	-1.2	-0.9
Pain experienced in last month	0.4	0.7	1.7	1.0	0.5	0.0	1.0	-0.4	-0.5	1.1	1.2	0.6	1.3	0.9
Supplements: Calcium	0.3	0.3	2.7	-0.6	-0.5	0.3	-0.2	1.6	-0.1	0.1	-0.1	0.2	0.1	-0.2
Basal cell carcinoma (self-reported)	1.6	1.9	4.1	-1.5	-0.7	-0.4	-1.2	-1.2	0.8	-2.0	-1.8	-1.8	-1.5	-1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.2	0.3	-0.5	-0.8	0.8	0.9	-0.9	1.5	1.5	1.6	1.8	0.2
Deep venous thrombosis (DVT) (self-reported)	2.9	3.7	6.1	2.0	0.9	1.5	2.4	1.4	-2.2	1.9	2.0	1.7	2.1	2.5
Heart disease (siblings)	0.3	0.4	1.2	-0.9	0.0	-1.1	-0.7	-0.7	0.4	-0.3	-0.5	-0.2	-0.0	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.6	-0.3	1.2	1.1	-0.5	-0.9	-0.0	-0.9	-1.1	-0.8	-1.0	-0.3
Pack years of smoking	0.1	0.1	0.6	0.2	-0.3	-0.1	0.0	0.7	-0.5	-0.4	-0.2	-0.4	-0.2	0.2
Impedance of whole body	0.3	1.6	6.7	1.0	-1.1	0.6	1.4	1.5	0.3	1.2	0.9	0.7	2.6	1.1
Leg fat mass (left)	0.2	0.8	2.0	-1.4	-1.4	-1.1	-1.0	-0.1	0.1	0.2	0.4	0.6	-0.6	-1.2
Arm predicted mass (left)	0.1	0.7	2.5	-0.4	0.6	-0.9	-0.3	-0.7	-1.6	0.1	0.5	0.7	-1.4	-0.4