Hub : Genes

KCNN4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2190 0.0410 4.4e-16 0.206 0.171 0.198 0.201 0.199 1.5e-24 2.7e-20 1.3e-23 5.3e-24 1.1e-23
2 GTEx Brain Caudate basal ganglia 0.2250 0.0820 5.2e-03 0.107 NA 0.197 NA 0.243 5.6e-04 NA 2.6e-06 NA 1.3e-07
3 GTEx Brain Frontal Cortex BA9 0.4350 0.1444 7.8e-03 -0.007 NA 0.093 NA 0.052 5.5e-01 NA 2.0e-03 NA 1.7e-02
4 GTEx Brain Hypothalamus 0.2570 0.1020 5.2e-03 0.101 NA 0.075 NA 0.143 2.4e-03 NA 8.1e-03 NA 3.2e-04
5 GTEx Nerve Tibial 0.1696 0.0622 4.9e-03 0.002 NA 0.022 NA 0.021 2.2e-01 NA 1.0e-02 NA 1.1e-02
6 GTEx Testis 0.3800 0.0810 9.5e-09 0.379 NA 0.324 NA 0.367 7.4e-18 NA 5.6e-15 NA 3.3e-17
7 GTEx Whole Blood 0.1590 0.0420 9.5e-08 0.121 NA 0.104 NA 0.109 3.0e-11 NA 7.5e-10 NA 3.2e-10
8 NTR Blood 0.0558 0.0143 4.9e-14 0.073 0.052 0.065 0.068 0.071 2.2e-22 3.0e-16 3.6e-20 6.3e-21 5.4e-22
9 YFS Blood 0.2504 0.0376 0.0e+00 0.224 0.243 0.260 0.258 0.249 1.3e-71 1.6e-78 7.1e-85 3.8e-84 1.4e-80
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0268 0.0152 3.9e-03 0.019 0.014 0.005 NA 0.010 2.6e-03 9.0e-03 8.0e-02 NA 2.3e-02
11 TCGA Brain Lower Grade Glioma 0.0583 0.0251 2.1e-05 0.059 0.033 0.038 NA 0.043 3.1e-07 1.1e-04 3.2e-05 NA 1.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.7 1.1 3.7 -0.4 1.9 1.5 -0.6 -0.2 0.5 -1.1 -1.3 -0.6 -1.1 -0.5
Bipolar Disorder or Schizophrenia 0.5 1.2 5.0 0.5 2.0 2.2 -0.3 -1.0 -0.6 -0.7 -0.8 -0.7 -0.9 0.2
Depressed Affect (Nagel 2018) 1.8 3.8 9.2 1.6 -0.3 0.5 2.0 3.0 -2.2 2.4 2.7 1.6 1.5 1.8
Depression (Nagel 2018) 0.2 0.3 1.0 0.2 0.3 -0.1 0.3 0.1 -0.7 -0.7 -0.3 -1.0 -1.0 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.2 1.0 0.1 -0.0 -1.0 -0.3 -0.1 1.0 -0.3 -0.5 -0.1 -0.1 -0.4
Neuroticism (Nagel 2018) 0.8 1.8 4.4 1.4 0.7 1.3 1.7 0.8 -2.1 1.3 1.6 0.8 0.8 1.6
Schizophrenia (2018) 0.4 0.7 2.7 0.9 0.9 1.6 0.1 -1.2 -1.2 -0.0 -0.0 -0.4 -0.3 0.6
Schizophrenia vs Biploar Disorder 0.5 0.6 3.4 -0.5 -0.9 -1.2 -0.3 -1.8 0.2 -0.2 0.0 -0.0 0.3 -0.7
Worry (Nagel 2018) 0.2 0.4 2.1 0.3 0.9 0.9 0.3 -1.5 -0.2 -0.3 -0.1 -0.3 -0.1 0.3
Alzheimer’s Disease (in mother) 5.2 6.1 9.7 -2.8 -0.9 -1.5 -3.1 -1.8 2.7 -2.7 -2.9 -2.4 -2.2 -3.0
Alzheimer’s Disease (in father) 1.0 1.0 3.4 0.2 1.8 1.1 -0.3 -0.8 -0.3 -1.3 -1.4 -0.9 -1.2 0.1
Alzheimer’s Disease (including proxy) 5.7 8.2 15.4 -2.9 -0.5 -0.8 -3.4 -2.1 2.4 -3.8 -3.9 -3.0 -3.4 -3.0
Crohns Disease (2017) 0.7 1.5 4.0 -0.3 0.6 -0.2 -0.3 -1.7 0.4 -1.8 -1.6 -2.0 -1.6 -0.2
Irritable Bowel Disease (IBD) 0.6 1.3 3.1 -1.0 0.4 -0.3 -1.0 -1.8 0.9 -1.4 -1.4 -1.5 -1.3 -0.8
Ulcerative Colitis (UC) 0.2 0.3 0.9 -0.9 -0.1 -0.5 -0.9 -0.8 0.6 -0.0 -0.2 -0.0 -0.1 -0.8
Major Depression (MDD) 1.1 1.4 3.8 -1.3 -1.3 -1.6 -1.5 -0.2 2.0 -0.4 -0.5 -0.8 -0.7 -1.4
Reaction Time 1.4 2.8 7.7 2.3 0.6 0.9 2.8 -0.1 -0.9 1.6 1.5 0.6 2.0 2.4
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.7 -0.4 -1.3 -1.2 -0.7 -0.9 1.3 -0.8 -1.0 -0.8 -0.5 -0.6
Breast Cancer 15.8 38.1 73.6 -5.4 0.9 -0.5 -6.4 -5.3 4.6 -8.3 -8.4 -7.5 -8.6 -5.3
Ovarian Cancer 0.5 0.6 2.0 0.6 0.1 1.1 0.9 -0.1 -1.4 0.0 0.4 1.2 -0.2 1.0
Prostate Cancer 0.4 0.6 1.9 -0.5 -1.2 -1.0 -0.6 0.0 0.6 -0.4 -0.6 -1.4 0.1 -0.7
Age at First Birth 0.6 0.8 2.1 0.4 0.8 -0.2 0.7 -0.6 -1.4 1.2 1.2 1.1 0.9 0.6
Bipolar Disorder (2011) 0.4 0.4 2.0 0.6 1.4 1.2 0.2 -0.3 -0.1 -0.4 -0.3 -0.1 -0.4 0.5
Body Mass Index (BMI) (2010) 0.2 0.2 0.8 0.2 0.3 0.6 -0.2 -0.7 -0.7 -0.0 -0.0 -0.4 -0.9 0.1
Coronary Artery Disease (CAD) 0.3 0.4 1.6 0.0 0.2 -0.3 -0.3 -1.2 1.1 -0.3 -0.4 -1.0 -0.2 -0.0
Crohns Disease (2012) 0.3 0.5 1.3 0.3 0.4 0.3 0.3 -1.1 -0.0 -1.0 -1.0 -1.0 -0.9 0.5
Mean Putamen Volume 0.4 0.4 2.3 0.0 -0.4 -0.5 -0.1 1.5 0.9 -0.0 -0.2 -1.1 -0.1 -0.1
Fasting Glucose 0.4 0.4 1.3 -0.0 -0.1 0.4 0.1 0.6 -0.5 1.2 1.0 1.0 0.8 0.4
HbA1C 0.5 0.6 1.8 -0.5 0.2 0.2 0.2 -1.3 0.5 -1.0 -0.9 -0.7 -1.2 -0.4
HDL Cholesterol 0.1 0.2 0.7 0.1 0.8 0.7 0.1 0.1 -0.8 -0.4 -0.3 0.0 -0.6 0.2
LDL Cholesterol 0.9 1.4 4.3 -1.2 -0.1 -1.0 -1.1 -0.8 0.9 -1.8 -1.5 -0.3 -2.1 -0.8
Lupus 1.1 1.6 4.2 -1.5 -0.9 -2.0 -1.6 -0.6 1.4 -0.7 -0.8 -1.2 -0.2 -1.8
Neuroticism (2016) 1.1 1.6 2.9 1.4 0.4 0.8 1.6 0.8 -0.9 1.7 1.6 0.9 1.5 1.6
Primary Biliary Cirrhosis 0.2 0.2 1.5 0.2 1.2 0.1 0.2 -0.4 -0.3 -0.3 -0.4 -0.0 -0.4 0.4
Rheumatoid Arthritis 0.6 0.9 2.5 -1.0 -1.0 -0.9 -0.9 1.3 1.6 -0.0 -0.5 0.4 -0.2 -1.0
Schizophrenia (2014) 0.6 1.4 5.0 0.4 2.1 2.2 0.0 -1.8 -0.3 -0.7 -0.7 -0.9 -0.7 0.2
Triglycerides 0.1 0.2 1.0 0.4 -0.4 -0.6 0.4 -0.0 0.4 0.3 0.2 -1.0 0.5 0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.3 0.3 1.3 1.4 0.2 -1.3 1.3 -1.3 -1.5 -1.5 -1.2 0.3
Ulcerative Colitis 1.0 1.5 3.3 -1.5 -0.3 -0.3 -1.5 -1.3 1.8 -1.2 -1.5 -1.1 -0.7 -1.2
Blood Eosinophil Count 0.2 1.3 2.8 -0.8 -1.7 -0.9 -1.1 -0.7 -0.1 -1.4 -1.1 -1.5 -1.4 -0.7
Blood Platelet Count 0.2 2.2 8.4 -1.5 -2.9 -0.7 -1.4 0.8 1.1 -0.8 -1.1 -2.3 -0.9 -1.5
Blood Red Count 0.6 5.5 11.6 -2.2 -3.4 -2.3 -2.7 -0.5 2.7 -1.9 -1.6 -2.0 -1.9 -3.1
Blood White Count 1.0 7.1 13.8 -2.3 -2.2 -1.0 -2.3 -1.8 2.0 -3.5 -3.5 -3.7 -3.3 -2.4
Heel T-Score 0.6 4.8 9.4 -2.7 -1.8 -0.7 -2.1 -3.1 2.3 -2.8 -2.1 -1.6 -1.6 -2.3
BMI 0.4 2.0 4.8 -1.7 -1.0 -2.2 -1.8 -1.8 0.8 -0.7 -0.6 -0.5 -1.5 -1.8
Height 0.0 0.9 4.3 -0.6 0.3 -1.0 -0.0 1.2 -2.1 0.5 0.8 0.9 -0.8 -0.3
Waist Hip Ratio (WHR) 2.2 10.1 14.7 -3.7 -2.6 -2.6 -3.6 -2.4 3.8 -3.2 -3.0 -2.8 -3.2 -3.7
Systolic Blood Pressure 0.1 0.4 1.6 -0.2 -0.8 -0.1 0.1 0.7 0.3 0.8 0.9 0.3 1.2 -0.2
Smoking Status 0.1 0.2 1.1 0.4 0.4 -0.3 0.5 -1.1 -0.1 0.0 -0.2 -0.3 0.1 0.6
Allergy or Eczema 0.7 1.8 4.9 0.3 1.7 0.9 -0.1 -1.1 -0.0 -2.2 -1.8 -1.5 -2.1 0.5
Cardiovascular Disease 1.0 3.4 5.1 -1.7 -2.3 -1.9 -1.9 -1.7 1.7 -2.1 -1.8 -1.8 -1.6 -1.7
Hypothyroidism (self reported) 1.6 3.7 6.8 -1.6 -1.1 -0.9 -2.0 -1.5 1.9 -2.4 -2.6 -2.6 -1.7 -1.9
Respiratory disease 0.0 0.1 0.5 -0.1 -0.1 -0.1 0.1 0.7 -0.3 0.0 0.0 -0.0 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.3 -0.6 -0.7 -0.5 0.2 0.8 0.0 -0.1 -0.3 0.4 -0.7
Lung FEV1/FVC ratio 0.2 1.0 3.3 -0.9 -0.6 -0.7 -1.1 -1.8 -0.0 -1.1 -0.8 -1.1 -0.9 -1.0
Lung FVC 0.0 0.2 0.4 0.6 -0.2 -0.0 0.4 -0.6 0.3 -0.4 -0.4 -0.6 0.2 0.4
Neuroticism 0.4 1.0 2.8 0.8 -0.4 0.2 1.1 0.8 -1.4 1.4 1.7 0.6 0.8 0.9
Chronotype (morning person) 1.9 4.4 6.7 2.3 0.9 1.1 2.4 0.5 -2.6 2.5 2.6 2.0 2.4 2.3
Hair Pigment 0.4 12.2 21.3 4.6 3.8 3.6 4.2 1.0 -3.4 3.2 2.9 2.5 3.4 4.5
Tanning 0.0 0.4 1.0 -1.0 -0.8 -0.2 -1.0 -0.5 -0.4 -0.3 -0.4 0.2 -0.6 -0.6
Hand grip strength (left) 0.1 0.4 1.0 0.8 0.7 0.4 0.3 -0.3 -0.7 -0.5 -0.3 -1.0 -0.8 0.7
Number of treatments/medications taken 1.2 2.1 4.2 -1.4 -2.1 -1.2 -1.4 -0.3 0.9 -1.6 -1.3 -2.0 -1.6 -1.3
Average weekly spirits intake 1.3 1.6 5.0 -1.4 -2.2 -1.9 -1.5 0.4 1.0 -0.1 -0.0 -0.7 -0.5 -1.6
Sensitivity / hurt feelings 0.9 1.6 3.7 1.1 0.3 0.4 1.2 0.7 -1.5 1.9 1.9 1.0 1.4 1.1
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.5 -0.7 -0.6 -0.5 0.0 -0.3 -0.6 -0.8 -0.5 -1.1 -1.2 -0.2
Hearing difficulty/problems: Yes 0.3 0.5 1.7 -0.3 0.2 0.4 -0.1 -1.3 0.2 -0.9 -0.8 -0.8 -1.1 -0.1
Relative age of first facial hair 0.3 0.5 1.5 -0.6 -0.8 -0.6 -0.7 -0.5 1.2 -0.8 -1.0 -0.4 -0.4 -0.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.0 -0.4 0.9 0.9 -0.9 -0.9 0.4 -1.5 -1.2 -1.7 -1.7 -0.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.7 -1.3 -0.5 -0.5 -1.1 1.2 1.0 -0.5 -0.5 0.0 -0.6 -1.1
Ever had hysterectomy (womb removed) 0.8 0.9 2.0 -1.4 -1.4 -1.4 -1.2 0.7 0.5 -0.2 -0.1 0.0 -0.3 -1.1
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.3 0.7 0.9 0.1 -0.0 -0.5 0.5 0.9 0.4 0.5 0.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.8 0.4 -0.1 0.0 0.2 1.3 -0.4 1.2 1.1 0.8 0.7 0.0
Angina 1.5 1.9 7.4 -1.3 -2.0 -2.7 -1.1 -1.0 1.6 -0.0 -0.4 -0.2 0.7 -1.6
Medication for hormone replacement therapy 0.4 0.5 1.5 -0.7 -0.9 -0.9 -0.6 1.2 -0.5 0.6 0.4 0.2 0.3 -0.7
Vitamin and mineral supplements 0.3 0.4 2.0 0.2 0.8 -0.1 0.4 0.3 -0.8 0.7 0.6 1.4 0.3 0.3
Supplements: Zinc 0.4 0.4 1.8 0.4 -0.3 0.9 0.5 1.3 -0.3 0.6 0.7 0.1 0.8 0.3
Medication: Co-codamol 0.5 0.6 2.1 0.0 -1.2 -0.7 0.4 1.4 0.7 0.6 0.8 0.5 1.0 0.1
Medication: Metformin 0.1 0.2 0.5 -0.3 -0.3 0.0 -0.6 0.7 0.3 0.2 0.2 -0.3 0.2 -0.7
Diabetes (father) 0.9 1.1 3.1 1.2 0.3 0.7 1.0 1.4 -0.7 1.2 0.9 0.7 1.7 0.9
Diabetes (mother) 0.2 0.3 1.1 -0.8 -0.2 -1.0 -0.7 -0.1 0.2 0.0 0.1 0.3 0.1 -0.8
Severe depression (siblings) 0.1 0.1 0.5 0.1 -0.1 0.0 -0.1 -0.1 -0.7 0.1 0.1 -0.3 -0.1 0.2
Pack years adult smoking proportion 0.1 0.1 0.5 0.2 -0.1 -0.1 0.0 0.7 -0.6 -0.4 -0.2 -0.6 -0.3 0.1
Impedance of leg (right) 0.4 1.7 5.5 1.3 -0.8 0.8 1.4 2.0 0.0 1.2 1.1 0.4 2.4 1.2
Leg fat-free mass (left) 0.3 1.4 4.8 -1.6 0.1 -1.4 -1.3 -1.1 -0.1 -0.8 -0.5 -0.0 -2.2 -1.4
Trunk fat percentage 0.2 0.8 2.9 -1.3 -1.7 -1.1 -0.6 -0.2 0.4 0.6 0.7 0.9 0.3 -0.9
Hand grip strength (right) 0.5 1.3 4.3 0.0 0.8 0.2 -0.5 -1.4 -0.1 -1.3 -1.3 -2.1 -1.9 -0.1
Townsend deprivation index at recruitment 0.2 0.3 1.2 0.5 0.1 0.8 0.3 -0.5 -0.9 0.1 -0.2 -1.1 0.4 0.4
Current tobacco smoking 2.5 4.2 8.0 2.2 1.7 2.1 2.3 0.3 -2.8 2.1 2.0 1.6 2.0 2.3
Average weekly fortified wine intake 1.5 1.7 6.4 0.9 1.7 2.5 0.3 -0.4 0.1 -1.3 -1.6 -1.0 -1.6 0.8
Maternal smoking around birth 0.4 0.6 1.7 -0.9 -0.5 0.0 -1.1 -0.6 -0.5 -0.8 -0.7 -0.7 -1.3 -0.9
Fed-up feelings 0.5 0.9 3.3 -0.5 -1.8 -1.2 0.2 1.5 -0.7 0.7 1.1 -0.2 0.0 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.1 -0.6 -0.1 -0.8 -0.4 0.2 -0.3 -0.5 -0.1 -1.1 -0.8 -0.6
Relative age voice broke 0.6 0.9 2.6 -0.4 0.3 -0.0 -0.8 -1.6 0.8 -1.3 -1.5 -1.0 -0.9 -0.5
Taking other prescription medications 0.6 1.0 2.6 -1.2 -1.0 -0.6 -1.1 -0.5 0.4 -0.9 -0.7 -1.2 -1.6 -0.9
Age when periods started (menarche) 0.5 1.3 4.3 -0.9 -0.7 -0.5 -1.3 -0.5 1.0 -1.2 -1.2 -2.1 -1.0 -1.0
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 8.2 -1.1 -2.1 -2.9 -0.5 2.1 -0.1 1.8 1.9 1.9 2.1 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.2 -1.6 -0.2 0.1 -1.4 -2.3 1.1 -2.2 -1.6 -1.1 -1.9 -1.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.1 -0.6 0.2 -0.1 -0.9 -0.4 0.6 -0.8 -1.0 -1.0 -0.9 -0.5
Qualifications: CSEs or equivalent 0.8 1.1 2.4 -1.4 -1.4 -1.5 -1.5 -1.1 0.1 0.3 0.0 -0.0 0.3 -1.5
Serious illness, injury or assault to yourself 0.3 0.3 1.1 -0.8 0.6 -0.1 -0.8 0.1 -0.2 -0.2 0.1 0.4 -1.1 -0.7
High blood pressure 0.5 1.3 3.7 -1.3 -1.9 -1.3 -1.2 0.2 1.4 -0.7 -0.5 -0.6 -0.6 -1.3
Hayfever, allergic rhinitis or eczema 0.9 2.1 6.2 -0.5 0.9 0.2 -0.5 -1.4 1.0 -2.5 -2.1 -1.7 -2.1 -0.1
Multivitamins +/- minerals 0.5 0.7 1.8 -0.6 -1.3 -0.9 -0.6 -0.5 1.0 -0.7 -0.5 -1.2 -0.1 -0.7
Stomach or abdominal pain in last month 2.3 2.8 6.8 -0.4 1.7 0.8 -0.9 -2.0 0.8 -2.3 -2.2 -2.1 -2.6 -0.4
Supplements: Glucosamine 0.1 0.2 0.6 -0.3 -0.8 -0.1 -0.2 -0.1 0.8 -0.1 -0.2 -0.1 0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 2.5 3.0 6.2 -1.8 0.0 -0.7 -1.9 -1.5 1.8 -1.7 -1.8 -2.5 -2.0 -1.9
Medication: Atenolol 1.2 1.5 8.9 -0.4 -1.8 -3.0 -0.3 -0.4 1.6 0.5 0.4 0.3 1.1 -0.6
Medication: Levothyroxine sodium 2.6 4.5 7.5 -2.1 -1.8 -0.7 -2.1 -1.5 2.4 -2.6 -2.7 -2.7 -1.7 -2.1
Sitting height 0.3 1.9 6.8 -1.8 0.4 -0.8 -1.4 -0.5 -0.2 -1.8 -1.3 -0.6 -2.6 -1.4
Chronic bronchitis/emphysema (father) 1.5 1.8 5.4 -2.2 -0.7 -1.2 -2.0 -0.3 1.1 -0.9 -0.9 -0.7 -0.6 -2.3
High blood pressure (mother) 1.6 2.3 5.0 1.7 -0.5 0.4 1.9 0.4 -1.6 1.9 2.2 1.1 1.6 1.7
Body mass index (BMI) 0.3 1.4 2.9 -1.7 -1.0 -1.5 -1.6 -1.3 0.5 -0.5 -0.3 -0.2 -1.4 -1.7
Impedance of leg (left) 0.4 2.1 7.2 1.3 -1.0 0.7 1.5 1.8 -0.2 1.5 1.4 1.0 2.7 1.3
Leg predicted mass (left) 0.2 1.2 4.6 -1.4 0.2 -1.3 -1.2 -1.1 -0.2 -0.8 -0.5 -0.0 -2.1 -1.3
Trunk fat mass 0.2 0.8 2.1 -1.5 -1.4 -1.2 -0.9 -0.3 0.0 0.4 0.5 0.7 -0.3 -1.2
Waist circumference 0.5 1.8 4.2 -2.1 -0.9 -1.3 -1.9 -1.1 0.7 -0.7 -0.5 -0.4 -1.6 -2.0
Number of incorrect matches in round 0.1 0.2 1.3 0.1 0.3 -0.5 0.1 1.1 -0.7 0.2 0.0 -0.2 -0.2 0.1
Past tobacco smoking 1.0 1.8 4.4 1.1 0.0 1.0 0.9 1.4 -2.1 1.7 1.8 0.8 1.6 1.0
Alcohol usually taken with meals 0.9 1.5 3.6 -0.4 1.1 0.7 -0.7 -1.0 0.8 -1.9 -1.9 -1.5 -1.6 -0.4
Nervous feelings 0.5 1.0 2.6 0.5 0.1 -0.2 1.0 0.1 -1.1 1.1 1.5 1.6 1.4 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 -0.3 -0.1 -0.5 0.4 1.0 -0.6 0.3 0.8 -0.1 0.3 0.1
Hearing difficulty/problems with background noise 0.5 0.8 2.3 -0.4 0.1 0.8 -0.1 -1.2 0.6 -1.2 -1.1 -0.8 -1.5 0.0
Hair/balding pattern: Pattern 2 0.1 0.2 1.3 0.4 -0.0 0.0 0.4 -1.1 -0.4 -0.2 -0.0 0.1 0.1 0.5
Had menopause 0.4 0.5 1.5 -0.2 -0.1 -0.3 -0.3 0.9 -0.5 1.0 0.9 1.2 0.6 -0.1
Had other major operations 0.1 0.1 0.7 0.1 0.1 0.9 0.1 0.5 -0.1 0.7 0.3 0.2 -0.0 0.0
Forced vital capacity (FVC) 0.2 0.8 2.5 1.6 0.1 0.1 1.3 0.7 -0.8 0.8 0.7 0.2 0.9 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.0 -1.5 0.1 0.5 -1.4 -1.5 1.0 -2.0 -1.5 -1.0 -1.9 -1.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.8 0.5 -0.3 -0.9 0.6 0.5 -0.0 0.3 0.7 -0.2 -0.0 0.5
Qualifications: None of the above 0.5 1.1 6.6 0.1 0.4 0.6 -0.1 2.6 0.2 1.1 0.9 1.2 1.1 -0.1
Financial difficulties in last 2 years 0.9 1.2 3.6 -1.1 -0.3 0.2 -0.9 -0.3 0.2 -1.4 -1.4 -1.5 -1.9 -1.0
Mouth/teeth dental problems 1.1 1.6 3.4 -1.4 -0.7 -0.8 -1.8 -0.8 0.9 -1.7 -1.3 -0.2 -1.5 -1.7
Heart attack 0.9 1.1 2.6 0.5 -0.2 -0.5 0.9 0.9 -1.0 1.4 1.4 1.6 1.6 0.4
Allergy 0.3 0.6 2.4 0.4 -0.5 -0.2 0.1 0.6 0.2 1.6 1.3 1.0 1.1 -0.2
Pain all over the body in last month 0.4 0.4 2.2 -0.1 -0.1 0.2 0.4 1.5 -0.9 0.5 0.7 0.9 0.4 0.1
Diabetes (self-reported) 0.3 0.5 1.6 -1.1 -0.2 -0.7 -1.2 0.2 0.8 -0.1 -0.1 -0.5 -0.4 -1.3
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 7.5 0.4 2.7 1.8 -0.7 -1.1 -0.1 -2.2 -2.1 -1.2 -2.7 0.4
Medication: Ramipril 0.9 1.1 2.5 -1.5 -0.9 -1.2 -1.4 0.1 1.5 -0.6 -0.6 -0.2 -0.7 -1.6
Medication: Simvastatin 2.3 3.4 6.4 -1.1 0.5 -1.1 -1.5 -2.5 1.8 -2.5 -2.5 -1.6 -2.4 -1.4
Fluid intelligence score 0.4 0.8 4.8 -0.2 0.1 -0.1 -0.6 -2.2 -0.0 -1.0 -1.1 -1.2 -0.5 -0.2
Illnesses of siblings 1.0 1.3 4.1 1.2 2.0 1.2 1.0 0.2 -2.0 0.5 0.5 0.4 0.2 1.4
Neuroticism score 0.6 1.3 3.7 0.7 -0.3 -0.2 1.3 0.9 -1.6 1.6 1.9 0.7 1.0 1.0
Weight 0.3 1.4 3.5 -1.9 -0.8 -1.6 -1.5 -0.8 -0.1 -0.5 -0.2 0.0 -1.7 -1.7
Impedance of arm (right) 0.2 0.8 4.1 0.3 -0.8 0.4 0.8 1.1 0.5 0.8 0.6 0.7 2.0 0.6
Arm fat percentage (right) 0.2 0.9 2.5 -1.6 -1.4 -1.2 -1.1 -0.4 0.7 -0.0 0.1 0.4 -0.4 -1.4
Trunk fat-free mass 0.2 1.0 5.1 -1.0 0.7 -0.9 -0.9 -0.7 -1.1 -0.6 -0.3 -0.1 -2.2 -1.0
Hip circumference 0.1 0.4 1.4 -0.4 0.1 -0.4 -0.1 0.1 -1.1 0.8 1.0 1.2 -0.2 -0.3
Time employed in main current job 1.6 1.8 4.7 -0.7 0.8 0.4 -1.3 -0.9 1.6 -1.7 -1.8 -1.5 -2.2 -1.0
Alcohol intake versus 10 years previously 0.2 0.2 0.8 -0.2 -0.4 -0.9 -0.3 -0.7 0.4 0.2 0.1 0.3 0.7 -0.6
Father’s age at death 0.2 0.3 1.8 0.4 1.3 0.6 0.3 0.1 0.3 -0.2 -0.1 0.2 -0.6 0.5
Worrier / anxious feelings 0.1 0.1 0.4 0.1 -0.0 -0.4 0.4 -0.5 0.4 -0.2 -0.3 -0.6 -0.4 0.4
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.3 9.1 -2.2 0.2 -0.2 -1.8 -0.2 1.5 -2.4 -2.1 -2.0 -3.0 -1.7
Falls in the last year 2.0 2.7 6.3 -1.3 0.2 0.2 -1.6 -1.2 1.2 -2.3 -2.2 -2.0 -2.5 -1.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 0.1 -0.0 -0.5 0.2 -0.2 0.4 0.3 0.4 0.2 0.1 -0.1
Number of live births 0.1 0.2 0.7 0.3 0.9 0.5 0.3 0.2 -0.0 0.2 -0.0 -0.6 -0.3 0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 1.4 1.2 0.1 -0.1 0.8 -0.1 -0.7 0.2 0.3 -0.5 0.2 0.9
Pulse rate 0.1 0.3 0.8 -0.5 -0.9 0.0 -0.1 0.7 0.7 -0.5 -0.6 -0.1 -0.2 -0.3
Happiness 0.5 0.6 1.9 0.7 1.0 0.7 0.7 -1.1 -0.0 -0.8 -0.5 -1.4 -0.4 0.4
Noisy workplace 2.3 2.8 8.7 -0.3 -2.7 -1.9 0.5 1.7 1.0 1.8 1.5 1.2 2.9 -0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.9 0.6 1.5 1.3 0.5 -1.7 0.3 -0.9 -0.8 -0.8 -0.3 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 6.2 -1.4 -2.5 -1.3 -1.0 -1.3 1.4 -1.3 -1.0 -1.8 -0.9 -1.2
Mouth/teeth dental problems: Dentures 4.9 8.3 14.5 3.5 2.6 1.8 3.8 1.6 -2.1 3.3 2.9 2.5 2.9 3.7
Asthma 1.4 2.7 5.2 -1.8 -0.1 -0.3 -1.8 -0.9 1.1 -2.3 -2.2 -2.0 -2.2 -1.7
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.2 -1.8 -1.1 -1.2 -1.6 -0.6 1.1 -1.0 -1.1 -1.2 -1.0 -1.6
Medication: Cholesterol lowering 1.4 2.2 7.6 -1.6 -2.1 -2.8 -1.7 -0.4 1.3 -0.5 -0.7 -0.2 -0.4 -1.9
Depression (self-reported) 0.7 0.8 1.4 1.1 0.6 1.1 1.1 0.9 -1.1 1.0 0.9 0.2 0.1 1.2
Medication: Lansoprazole 0.4 0.4 1.5 -0.3 1.2 0.7 -0.1 0.1 -0.7 -0.6 -0.5 -0.5 -1.0 -0.1
Prospective memory result 0.3 0.3 1.0 -0.6 0.4 -0.7 -0.2 -1.0 1.0 -0.4 -0.4 -0.3 -0.0 -0.4
Lung cancer (father) 0.3 0.4 1.2 -1.1 -1.0 0.1 -0.7 0.6 -0.3 0.2 -0.1 0.3 0.1 -0.9
Illnesses of mother 0.2 0.3 0.8 0.7 0.7 0.6 0.9 0.4 -0.5 0.2 -0.1 0.1 0.4 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 2.2 0.5 0.1 -0.2 0.1 -0.6 0.2 -0.7 -0.7 -1.5 -0.6 0.3
Pulse wave Arterial Stiffness index 2.4 2.8 5.6 -2.4 -1.5 -0.9 -2.0 -0.3 1.4 -1.9 -1.9 -1.5 -1.4 -2.1
Impedance of arm (left) 0.1 0.7 3.5 0.2 -1.0 0.5 0.6 0.9 0.8 0.6 0.3 0.4 1.9 0.5
Arm fat mass (right) 0.2 0.8 2.4 -1.5 -0.6 -0.9 -1.2 -0.9 0.2 -0.3 -0.1 0.2 -1.1 -1.4
Trunk predicted mass 0.2 0.9 4.7 -0.9 0.8 -0.9 -0.8 -0.7 -1.1 -0.5 -0.2 -0.0 -2.2 -0.9
Standing height 0.0 0.3 1.9 -0.4 0.4 -0.4 0.1 0.6 -1.4 -0.1 0.2 0.5 -0.9 -0.1
Length of working week for main job 0.1 0.1 0.7 -0.2 -0.1 -0.4 0.2 0.8 -0.1 0.1 0.3 -0.3 0.3 -0.2
Exposure to tobacco smoke at home 1.5 1.7 4.4 1.2 0.5 0.6 1.3 0.9 -1.3 1.8 1.7 0.8 2.1 1.1
Breastfed as a baby 2.4 2.9 6.2 -2.4 -0.2 -0.2 -2.5 -0.5 1.9 -1.9 -1.9 -0.7 -2.1 -2.1
Tense / ‘highly strung’ 0.5 0.9 2.8 1.2 0.5 0.9 1.7 0.5 -0.4 0.6 0.7 0.1 0.8 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.9 0.4 -0.1 0.1 0.7 0.9 -0.9 1.0 1.0 0.3 0.5 0.6
Hair/balding pattern: Pattern 4 0.6 1.5 3.3 -1.6 -0.1 -1.1 -1.7 -0.6 0.9 -1.2 -1.1 -1.3 -0.9 -1.8
Birth weight of first child 1.1 2.0 4.0 -1.9 0.2 -0.6 -1.9 -1.2 0.4 -1.5 -1.3 -1.4 -2.0 -1.8
Peak expiratory flow (PEF) 1.1 2.6 5.6 2.4 1.2 1.0 2.2 0.5 -1.9 1.2 1.4 1.3 1.2 2.3
Pulse wave reflection index 3.7 4.5 6.8 -2.5 -1.0 -1.0 -2.6 -1.4 1.8 -2.4 -2.5 -2.5 -2.3 -2.4
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.7 0.5 -0.3 -1.3 0.5 -0.2 -0.5 0.3 0.5 -0.2 0.1 0.5
Loud music exposure frequency 0.3 0.3 1.2 -0.2 -0.7 -0.0 0.4 -0.7 1.1 -0.4 -0.4 -0.6 -0.3 0.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 7.5 0.1 -0.2 -0.4 -0.1 -2.7 -0.6 -0.1 -0.1 -0.6 -0.3 0.3
Mouth/teeth dental problems: Bleeding gums 1.3 1.6 3.6 1.7 0.1 0.6 1.9 -0.3 -1.3 1.4 1.3 0.6 1.6 1.7
Blood clot in the leg (DVT) 2.5 3.2 5.9 1.9 1.1 1.6 2.4 1.2 -2.1 1.6 1.7 1.5 1.9 2.4
Medication: Paracetamol 0.2 0.3 0.6 0.8 -0.1 0.4 0.8 0.4 -0.8 0.5 0.4 -0.3 -0.0 0.8
Headache pain in last month 1.8 3.1 6.1 2.4 1.9 1.8 2.3 1.2 -2.1 1.3 1.1 0.9 1.0 2.5
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 8.5 1.6 2.6 2.9 1.6 -0.0 -0.9 0.3 0.1 0.0 0.4 1.7
Glaucoma (self-reported) 3.9 4.6 9.8 -2.9 -1.7 -1.3 -2.9 -0.3 2.0 -2.1 -2.1 -1.9 -1.8 -3.1
Gout (self-reported) 0.5 0.7 4.8 -0.9 -2.2 -0.7 -0.6 -0.1 0.3 -0.2 0.0 -0.4 0.2 -0.9
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 4.8 -1.1 -0.8 -0.3 -1.3 -1.2 1.5 -1.9 -1.9 -2.2 -1.2 -1.3
Medication: Amlodipine 0.5 0.7 2.4 -0.7 -1.6 -1.2 -0.3 0.8 0.6 0.7 0.6 0.5 0.6 -0.6
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.8 -1.7 -0.3 -1.2 -1.5 -0.2 0.4 -0.8 -0.6 -0.4 -0.7 -1.6
Birth weight 0.3 0.7 2.0 1.1 0.7 -0.6 1.4 -0.0 -0.8 0.7 0.9 0.5 0.5 1.2
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.9 0.7 -0.2 0.4 0.8 1.0 -0.2 0.3 0.3 0.3 0.6 0.5
High blood pressure (siblings) 0.9 1.2 4.8 -0.9 -1.6 -1.4 -0.8 -0.9 2.2 -0.3 -0.4 -0.6 -0.2 -1.2
Forced vital capacity (FVC), Best measure 0.1 0.4 1.4 1.2 0.2 0.0 1.0 0.4 -0.1 0.2 0.1 -0.3 0.3 1.1
Body fat percentage 0.2 0.8 2.9 -1.2 -1.7 -1.1 -0.7 0.1 0.3 0.6 0.8 0.9 0.3 -0.9
Leg fat percentage (right) 0.3 0.9 4.0 -1.2 -2.0 -1.2 -0.8 0.6 0.6 0.4 0.6 0.5 0.2 -1.2
Arm fat-free mass (right) 0.1 0.6 2.8 -0.6 0.7 -0.7 -0.5 -0.9 -1.3 -0.1 0.2 0.3 -1.7 -0.5
Exposure to tobacco smoke outside home 0.6 0.8 2.5 1.3 0.5 1.6 1.2 -0.0 -0.9 0.4 0.2 -0.8 0.6 1.0
Comparative body size at age 10 0.1 0.4 1.1 -0.4 -0.4 -1.1 -0.5 0.8 -0.6 0.5 0.7 0.3 -0.1 -0.5
Number of full brothers 1.0 1.3 2.9 -1.6 0.2 -0.7 -1.4 -0.9 1.2 -1.0 -1.0 -0.9 -1.0 -1.7
Worry too long after embarrassment 0.5 0.8 2.7 -1.3 -1.5 -1.6 -0.7 0.4 0.4 -0.1 0.0 -0.4 -0.4 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.9 -0.7 0.5 0.5 -0.6 -0.2 0.5 -0.9 -0.9 -0.7 -1.4 -0.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 -0.7 -0.5 -0.4 -0.5 -0.2 -0.1 -0.3 -0.4 -0.7 -0.3 -0.5
Number of children fathered 1.3 1.4 4.5 -2.1 -0.8 -1.5 -1.7 -0.2 1.0 -0.2 -0.2 0.5 -0.4 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 6.7 -0.5 0.8 0.0 -0.5 -1.1 0.5 -1.3 -1.0 -0.9 -2.6 -0.3
Age at first live birth 0.5 0.9 4.4 0.6 2.1 1.5 0.3 -0.8 -0.8 -0.4 -0.4 -0.2 -0.8 0.7
Pulse wave peak to peak time 2.0 2.3 4.6 2.1 1.3 0.6 1.8 0.2 -1.4 1.8 1.8 1.4 1.3 1.9
Health satisfaction 0.5 0.7 1.5 0.3 0.7 1.2 0.5 -1.1 -0.5 -1.1 -0.5 -1.2 -0.9 0.4
Shortness of breath walking on level ground 0.1 0.1 0.7 -0.1 -0.2 -0.3 0.2 0.1 -0.8 0.5 0.6 0.3 0.0 -0.1
Qualifications: College or University degree 0.7 2.2 5.4 -0.8 0.5 0.4 -0.9 -1.8 1.4 -2.3 -2.3 -1.5 -1.9 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.6 -0.1 -0.8 0.2 -0.1 -0.1 0.3 0.1 0.2 0.5 -0.2 0.1
Mouth/teeth dental problems: Loose teeth 2.0 2.4 5.8 -1.4 -0.7 -0.2 -1.4 -2.4 1.0 -1.8 -2.0 -2.2 -1.2 -1.3
Emphysema/chronic bronchitis 1.0 1.1 2.4 1.3 0.3 0.1 1.6 -0.3 -1.1 0.9 1.0 1.3 1.4 1.3
Medication for pain relief, constipation, heartburn 0.3 0.6 1.3 0.8 1.1 1.0 0.5 -0.1 -0.8 0.4 0.4 0.9 0.9 0.8
Neck or shoulder pain in last month 0.1 0.2 0.5 -0.2 0.1 -0.4 -0.4 -0.5 -0.7 0.2 0.3 0.4 0.2 -0.6
Medication: Blood pressure 1.1 2.0 6.8 -1.4 -2.4 -2.6 -1.2 1.2 0.4 0.8 0.9 0.6 0.6 -1.5
Angina (self-reported) 1.5 1.9 7.8 -1.1 -2.1 -2.8 -0.8 -0.8 1.6 0.3 -0.1 0.1 1.3 -1.5
Migraine (self-reported) 1.8 2.2 6.7 -1.7 -0.1 0.3 -1.8 0.1 2.6 -1.4 -2.1 -1.1 -1.3 -1.6
Medication: Ibuprofen 0.7 0.9 1.8 -1.4 -0.9 -1.0 -1.2 -0.5 1.0 -0.6 -0.7 -0.9 -0.4 -1.2
Medication: Allopurinol 0.2 0.3 1.2 0.1 -1.1 -0.1 0.4 0.2 -0.5 0.3 0.7 0.5 0.7 0.1
Medication: Omeprazole 0.5 0.6 1.6 -1.1 -1.0 -0.3 -1.3 -0.2 -0.0 -0.6 -0.4 -0.6 -1.1 -1.0
Medication: Seretide 50 evohaler 0.5 0.5 1.5 0.4 0.4 1.1 0.5 1.2 -1.2 0.6 0.5 0.1 0.3 0.5
Mean time to correctly identify matches 1.2 2.2 4.8 1.6 -0.0 0.9 2.2 0.3 -1.1 1.8 1.6 1.3 1.9 1.9
Heart disease (mother) 0.1 0.1 0.4 -0.3 0.2 -0.0 -0.1 -0.0 -0.2 0.5 0.5 0.7 0.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.1 -1.5 -1.1 -1.4 -1.4 -0.1 0.1 -0.3 -0.2 -0.6 -1.1 -1.4
Whole body fat mass 0.1 0.6 1.5 -1.2 -1.0 -1.0 -0.9 -0.5 -0.0 0.2 0.4 0.6 -0.6 -1.0
Leg fat mass (right) 0.2 0.8 2.1 -1.4 -1.5 -1.2 -1.1 -0.0 0.3 0.1 0.3 0.4 -0.7 -1.3
Arm predicted mass (right) 0.1 0.6 2.1 -0.3 0.7 -0.8 -0.3 -0.7 -1.4 0.1 0.4 0.6 -1.4 -0.4
Pulse rate, automated reading 0.3 0.8 1.9 1.1 -0.5 0.5 1.4 0.7 -0.8 0.8 1.2 0.4 0.5 1.3
Alcohol intake frequency. 1.0 2.4 5.5 1.0 0.1 -0.4 1.6 0.7 -2.1 2.1 2.3 1.7 2.0 1.0
Comparative height size at age 10 0.4 2.0 4.4 -0.4 -0.6 -1.1 0.1 1.9 -2.1 1.8 1.9 2.0 0.9 -0.1
Number of full sisters 0.8 0.9 2.6 -1.5 -1.6 -0.9 -1.0 1.1 0.3 -0.2 0.0 -0.4 -0.1 -1.4
Suffer from ‘nerves’ 0.3 0.5 1.6 -0.4 0.8 0.5 -0.4 -1.3 -0.3 -0.8 -0.5 -0.9 -0.6 -0.2
Overall health rating 0.3 0.7 1.6 -1.0 -0.3 0.4 -0.9 0.5 0.2 -0.7 -0.6 -1.1 -1.2 -1.0
Chest pain or discomfort 0.8 1.1 2.6 -0.1 -1.3 -1.5 0.6 1.0 -0.6 1.2 1.4 0.7 1.6 -0.0
Had major operations 0.9 1.1 4.2 -0.4 -2.0 -1.0 -0.1 1.8 -0.6 0.9 0.9 0.6 0.8 -0.3
Age at last live birth 0.4 0.5 1.6 0.1 1.3 1.1 0.4 -0.7 -1.1 0.3 0.5 0.6 0.1 0.4
Family relationship satisfaction 1.6 2.0 5.6 1.7 2.4 2.1 1.5 -1.2 -1.1 -0.3 -0.4 0.1 -0.5 1.8
Leg pain on walking 0.5 0.6 2.5 -0.5 0.4 0.8 -0.4 -1.6 0.4 -0.9 -0.8 -0.4 -0.8 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 4.9 -0.4 -0.4 -0.8 -0.9 -1.3 0.7 -1.3 -1.2 -2.2 -1.4 -0.7
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.4 0.2 1.0 0.6 -0.2 -1.2 0.4 -0.9 -0.9 -0.6 -1.6 -0.0
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 4.6 2.1 1.5 1.2 1.7 0.2 -0.8 1.7 1.2 1.2 1.9 2.0
Medication: Aspirin 0.9 1.2 3.7 -1.2 -0.3 -1.9 -1.1 -0.9 1.2 -1.0 -0.8 -0.4 -0.9 -1.3
Supplements: Vitamin C 0.3 0.4 2.5 0.4 0.6 1.6 0.1 0.4 0.0 0.1 -0.1 -0.7 0.0 0.5
Knee pain experienced in last month 0.1 0.1 0.9 -0.4 -0.1 0.3 -0.1 -0.4 -0.1 0.4 0.2 0.9 0.1 -0.2
Hypertension (Self-reported) 0.6 1.6 2.8 -1.5 -1.6 -1.2 -1.4 -0.3 1.7 -1.1 -0.9 -1.0 -1.0 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 -0.1 -0.4 -0.7 0.2 0.1 -0.3 -0.5 -0.4 -1.1 -1.1 0.1
Illnesses of father: Heart disease 1.2 1.7 5.0 1.9 0.6 0.2 1.9 -0.5 -2.0 0.5 0.9 0.6 0.3 2.2
Illnesses of siblings: Diabetes 2.7 3.3 9.0 -2.5 -2.1 -2.0 -1.9 -0.5 3.0 -1.1 -1.2 -0.0 -0.7 -2.4
Smoking status: Previous 2.3 3.4 7.4 -1.6 -0.8 -2.1 -1.6 -1.3 2.7 -2.1 -2.2 -1.5 -2.0 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.1 1.1 -0.2 -0.4 1.2 1.0 -0.6 1.4 0.9 -0.3 1.4 0.9
Whole body fat-free mass 0.2 1.0 4.7 -1.1 0.5 -1.1 -0.9 -0.9 -0.9 -0.6 -0.3 0.0 -2.2 -1.0
Leg fat-free mass (right) 0.2 1.2 4.1 -1.4 0.3 -1.3 -1.1 -1.4 -0.3 -0.8 -0.4 0.2 -2.0 -1.3
Arm fat percentage (left) 0.2 0.8 2.1 -1.4 -1.4 -1.1 -1.0 -0.4 0.6 0.1 0.2 0.5 -0.2 -1.2
Average weekly red wine intake 1.0 1.5 3.1 -1.0 0.4 -0.4 -1.3 -1.2 0.7 -1.8 -1.7 -1.5 -1.8 -0.9
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.9 0.6 0.7 -0.0 0.5 -0.0 0.9 -0.5 -0.4 -0.3 0.3 0.4
Mood swings 0.6 1.1 3.6 0.8 -0.1 0.4 1.2 1.9 -0.9 1.1 1.4 0.8 0.7 1.0
Loneliness, isolation 0.9 1.2 4.6 0.6 0.8 0.5 0.9 0.5 -2.1 1.4 1.7 0.6 0.5 0.8
Long-standing illness, disability or infirmity 1.8 2.8 4.9 -2.0 0.1 0.1 -2.2 -1.4 0.6 -2.2 -1.9 -1.8 -2.2 -1.7
Ever had bowel cancer screening 0.3 0.3 1.2 -0.1 0.8 1.1 -0.2 -0.6 0.5 -0.7 -0.6 -0.3 -0.5 0.0
Diabetes diagnosed by doctor 0.3 0.4 0.8 -0.7 0.6 -0.0 -0.9 0.2 0.7 -0.5 -0.5 -0.8 -0.8 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.6 -0.7 0.5 -0.6 -0.8 -0.3 0.1 -0.7 -0.7 -0.5 -0.7 -0.6
Friendships satisfaction 0.9 1.1 4.2 1.4 2.1 1.3 0.9 -0.2 -1.3 -0.1 -0.1 -0.7 -0.5 1.1
Qualifications: nursing, teaching 0.2 0.3 0.9 -0.6 -1.0 -0.7 -0.0 -0.1 0.3 -0.9 -0.6 -0.0 -0.6 -0.2
Commuting to job workplace: Walk 0.5 0.6 1.6 0.1 0.6 1.2 0.1 -0.6 1.1 -0.5 -0.9 -1.2 -0.1 0.3
Eye problems/disorders: Cataract 0.3 0.3 2.2 0.0 0.0 -1.5 0.3 -0.4 -0.3 0.2 0.4 0.3 1.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.0 -1.3 0.3 -0.5 -1.1 -0.6 0.7 -1.4 -1.4 -1.3 -0.7 -0.9
Medication for cholesterol 0.4 0.6 1.3 0.5 0.4 0.4 0.6 1.0 -0.8 1.1 1.1 0.7 0.7 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.3 3.9 6.9 -2.6 -1.2 -1.3 -2.6 -2.0 1.6 -2.1 -2.1 -1.2 -1.6 -2.6
Back pain experienced in last month 0.3 0.4 1.3 -0.9 -0.5 0.3 -0.9 -0.1 0.2 -0.5 -0.7 0.0 -1.1 -0.8
Mineral and other dietary supplements 0.2 0.3 0.8 0.6 0.7 0.3 0.4 0.3 -0.9 0.4 0.4 0.3 -0.4 0.6
Breast cancer (self-reported) 3.8 4.5 10.3 1.5 -1.1 -0.1 1.6 1.0 -2.3 3.2 3.0 2.4 3.0 1.5
Asthma (self-reported) 1.4 2.8 5.7 -1.8 0.0 -0.2 -1.8 -0.7 1.0 -2.3 -2.2 -2.0 -2.4 -1.7
Osteoporosis (self-reported) 0.6 0.7 1.7 0.7 -0.2 -0.1 0.5 1.2 -0.7 1.2 0.9 1.0 1.3 0.6
Osteoarthritis (self-reported) 0.1 0.1 0.4 -0.1 -0.2 -0.2 -0.1 -0.1 -0.3 0.6 0.6 0.6 0.3 -0.3
Medication: Aspirin 1.1 1.4 4.2 -1.4 -0.5 -2.0 -1.2 -0.9 1.4 -0.9 -0.8 -0.5 -0.8 -1.5
Medication: Gliclazide 0.4 0.4 1.2 -0.4 -1.0 -0.8 -0.1 1.1 0.8 0.6 0.6 0.5 0.6 -0.3
Illnesses of father: None of the above (group 1) 0.6 0.7 1.8 -1.3 -0.5 -0.1 -1.4 -0.8 0.9 -0.5 -0.6 -0.1 -0.6 -1.4
Smoking status: Current 2.9 4.6 7.3 2.3 1.6 2.1 2.5 0.5 -2.7 2.2 2.2 1.9 2.3 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.4 0.6 -0.5 -0.5 0.1 -0.0 -0.5 0.3 0.3 -0.0 0.3 0.4
Whole body water mass 0.2 1.1 5.0 -1.1 0.6 -1.1 -1.0 -1.0 -0.9 -0.6 -0.3 0.0 -2.2 -1.1
Leg predicted mass (right) 0.3 1.4 4.6 -1.5 0.2 -1.3 -1.2 -1.4 -0.2 -0.8 -0.5 0.1 -2.2 -1.4
Arm fat mass (left) 0.2 0.8 2.2 -1.5 -0.8 -1.1 -1.1 -0.9 0.1 -0.2 0.0 0.3 -1.0 -1.3
Number of self-reported non-cancer illnesses 2.2 3.8 10.0 -1.4 0.5 0.9 -1.8 -1.2 -0.0 -2.7 -2.4 -3.1 -3.2 -1.2
Average weekly champagne plus white wine intake 0.6 0.8 3.0 0.8 1.7 1.6 0.6 -0.3 -0.2 -0.4 -0.3 0.2 -0.7 0.9
Miserableness 0.7 1.2 4.0 0.8 -1.3 -0.4 1.3 2.0 -0.4 1.1 1.3 0.6 0.8 1.1
Guilty feelings 0.4 0.6 2.9 -0.9 -0.9 -1.7 -0.5 -0.7 -0.4 0.0 0.2 -0.6 0.1 -0.7
Wears glasses or contact lenses 0.3 0.4 1.4 0.3 1.2 0.6 0.1 -0.3 -0.3 -0.9 -0.6 -0.4 -0.9 0.3
Ever taken oral contraceptive pill 0.9 1.0 1.7 -1.3 -1.0 -0.7 -1.1 0.0 1.3 -0.9 -1.1 -0.8 -1.2 -1.2
Hearing aid user 0.2 0.2 0.4 -0.5 -0.0 0.1 -0.7 0.7 0.1 -0.6 -0.3 -0.1 -0.3 -0.6
Mother’s age at death 0.6 0.8 1.9 1.0 1.1 1.4 0.9 -0.8 -1.2 0.2 0.2 0.5 0.4 1.1
Financial situation satisfaction 0.4 0.5 1.3 0.9 1.1 1.0 1.0 -0.4 -0.6 -0.0 0.0 -0.2 -0.1 0.8
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.0 -1.0 0.4 -0.8 -1.4 -0.9 0.3 -1.0 -0.7 -0.5 -1.3 -1.4
Commuting to job workplace: Public transport 0.6 0.7 4.7 -0.5 -2.2 -0.9 -0.2 1.1 0.7 0.1 0.1 -0.3 0.1 -0.4
Eye problems/disorders: Glaucoma 1.6 2.0 3.7 -1.6 -0.7 -0.7 -1.7 -0.6 1.2 -1.6 -1.5 -1.9 -1.2 -1.9
Medication: Blood pressure 0.1 0.1 0.4 0.4 -0.3 0.6 0.4 -0.5 0.4 -0.3 -0.2 -0.3 0.2 0.4
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.3 1.1 0.2 -0.0 1.4 0.8 -0.6 1.2 1.5 1.3 1.0 0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.8 -1.1 -1.9 -1.4 -1.0 0.1 1.9 -0.7 -0.6 -0.4 0.3 -1.3
High cholesterol (Self-reported) 2.3 4.1 8.9 -1.3 -0.6 -1.0 -1.7 -2.2 2.2 -3.0 -3.0 -2.1 -2.3 -1.5
Medication: Bendroflumethiazide 0.1 0.2 0.6 -0.4 -0.7 0.0 -0.5 0.5 0.2 -0.3 -0.2 -0.4 -0.8 -0.2
Medication: Paracetamol 0.1 0.2 0.4 0.4 -0.6 0.3 0.4 0.5 -0.2 0.1 0.2 -0.6 -0.5 0.4
Medication: Lisinopril 0.1 0.1 0.6 0.2 -0.0 0.8 -0.2 0.2 0.1 0.3 0.5 -0.0 0.4 -0.1
Medication: Atorvastatin 0.3 0.3 1.0 -0.7 -0.1 0.0 -0.9 0.1 0.9 -0.4 -0.3 -0.5 -0.1 -1.0
Illnesses of father: High blood pressure 4.5 5.6 9.1 3.0 1.0 1.4 3.0 1.3 -2.5 2.7 2.8 1.6 2.5 2.9
Alcohol drinker status: Never 0.3 0.4 2.0 0.1 -0.4 -1.1 0.1 -1.4 -0.2 0.2 0.2 -0.5 0.4 0.0
Ever smoked 0.3 0.4 1.6 -0.2 1.3 0.4 0.0 -1.2 0.2 -0.6 -0.6 0.1 -0.9 0.0
Basal metabolic rate 0.2 1.1 4.4 -1.2 0.3 -1.2 -1.0 -0.9 -0.6 -0.6 -0.2 0.0 -2.1 -1.2
Leg fat percentage (left) 0.3 1.0 4.2 -1.3 -2.1 -1.3 -0.9 0.1 0.6 0.4 0.6 0.8 0.2 -1.2
Arm fat-free mass (left) 0.1 0.8 3.7 -0.6 0.6 -0.9 -0.5 -0.7 -1.3 -0.3 0.2 0.4 -1.9 -0.6
Number of operations (self-reported) 0.6 0.8 4.0 -0.7 -1.3 -0.5 -0.3 2.0 -0.7 1.0 0.8 0.2 0.5 -0.6
Average weekly beer plus cider intake 0.5 0.8 2.1 -0.0 -0.2 0.9 -0.4 -0.8 0.2 -1.2 -1.4 -1.4 -1.1 -0.2
Irritability 0.5 0.8 2.0 1.2 0.7 1.1 1.4 -0.3 -0.8 0.6 0.7 0.5 0.1 1.3
Risk taking 1.6 2.3 6.0 -2.2 -0.7 -1.5 -2.5 0.4 1.2 -1.1 -1.2 -0.6 -1.1 -2.4
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.7 -0.4 -0.2 -0.0 -0.4 0.2 0.7 -0.8 -0.9 -1.1 -1.3 -0.2
Fractured/broken bones in last 5 years 1.3 1.7 3.4 1.4 1.2 1.6 1.4 1.0 -1.9 1.2 1.2 0.9 0.3 1.6
Age started oral contraceptive pill 0.6 0.8 1.5 -1.2 -1.2 -0.8 -1.1 1.0 0.5 -0.0 0.1 1.1 0.1 -1.1
Diastolic blood pressure, automated reading 0.2 0.5 1.9 0.6 -0.7 1.0 0.5 0.1 -0.9 0.8 1.4 0.4 0.4 0.5
Ever depressed for a whole week 0.3 0.3 1.2 -0.1 0.2 -0.5 -0.5 0.4 0.4 -0.9 -0.7 -0.6 -1.1 -0.3
Unable to work because of sickness or disability 1.3 1.7 4.5 -0.9 0.6 0.9 -0.8 -0.3 0.9 -1.7 -1.8 -2.1 -1.9 -0.8
Commuting to job workplace: Cycle 0.2 0.2 0.9 -0.1 0.5 -0.1 -0.1 0.9 0.1 0.4 0.6 0.7 0.2 -0.2
Myopia 0.1 0.2 1.1 -0.1 0.4 0.7 -0.4 0.0 -1.0 0.3 0.2 0.2 0.0 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.3 1.2 1.8 1.5 1.1 0.4 -1.1 0.5 0.3 0.5 0.6 1.3
Cholesterol lowering medication 2.6 3.9 9.0 -1.1 1.2 0.2 -1.5 -2.5 1.4 -3.0 -2.7 -2.2 -2.6 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.4 -1.0 -1.0 -0.4 -1.2 0.1 -0.1 -0.7 -0.4 -0.7 -1.2 -0.9
Pain experienced in last month 0.4 0.7 1.7 1.0 0.5 0.0 1.0 -0.4 -0.5 1.1 1.2 0.6 1.3 0.9
Supplements: Calcium 0.3 0.3 2.7 -0.6 -0.5 0.3 -0.2 1.6 -0.1 0.1 -0.1 0.2 0.1 -0.2
Basal cell carcinoma (self-reported) 1.6 1.9 4.1 -1.5 -0.7 -0.4 -1.2 -1.2 0.8 -2.0 -1.8 -1.8 -1.5 -1.3
Heart attack/myocardial infarction (self-reported) 1.0 1.2 3.2 0.3 -0.5 -0.8 0.8 0.9 -0.9 1.5 1.5 1.6 1.8 0.2
Deep venous thrombosis (DVT) (self-reported) 2.9 3.7 6.1 2.0 0.9 1.5 2.4 1.4 -2.2 1.9 2.0 1.7 2.1 2.5
Heart disease (siblings) 0.3 0.4 1.2 -0.9 0.0 -1.1 -0.7 -0.7 0.4 -0.3 -0.5 -0.2 -0.0 -0.9
Alcohol drinker status: Previous 0.6 0.7 1.6 -0.3 1.2 1.1 -0.5 -0.9 -0.0 -0.9 -1.1 -0.8 -1.0 -0.3
Pack years of smoking 0.1 0.1 0.6 0.2 -0.3 -0.1 0.0 0.7 -0.5 -0.4 -0.2 -0.4 -0.2 0.2
Impedance of whole body 0.3 1.6 6.7 1.0 -1.1 0.6 1.4 1.5 0.3 1.2 0.9 0.7 2.6 1.1
Leg fat mass (left) 0.2 0.8 2.0 -1.4 -1.4 -1.1 -1.0 -0.1 0.1 0.2 0.4 0.6 -0.6 -1.2
Arm predicted mass (left) 0.1 0.7 2.5 -0.4 0.6 -0.9 -0.3 -0.7 -1.6 0.1 0.5 0.7 -1.4 -0.4