Hub : Genes

IL18R1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3130 0.0430 0.0e+00 0.378 0.337 0.377 0.381 0.380 1.8e-48 3.2e-42 2.1e-48 5.4e-49 6.9e-49
2 GTEx Brain Caudate basal ganglia 0.1690 0.0650 5.1e-03 0.230 NA 0.175 NA 0.204 3.0e-07 NA 9.7e-06 NA 1.6e-06
3 GTEx Brain Cerebellar Hemisphere 0.2450 0.0860 2.1e-03 0.252 NA 0.098 NA 0.033 3.7e-07 NA 1.8e-03 NA 4.8e-02
4 GTEx Brain Cerebellum 0.2490 0.0660 2.5e-05 0.303 NA 0.256 NA 0.256 1.2e-09 NA 3.4e-08 NA 3.6e-08
5 GTEx Brain Cortex 0.2140 0.0760 2.6e-03 0.119 NA 0.103 NA 0.132 3.6e-04 NA 8.7e-04 NA 1.7e-04
6 GTEx Brain Hippocampus 0.2514 0.0820 5.4e-04 0.058 NA 0.032 NA 0.069 1.7e-02 NA 6.2e-02 NA 1.0e-02
7 GTEx Brain Putamen basal ganglia 0.2960 0.0940 1.9e-03 0.225 NA 0.243 NA 0.211 4.6e-06 NA 1.8e-06 NA 9.6e-06
8 GTEx Colon Transverse 0.1380 0.0550 5.4e-03 -0.002 NA 0.003 NA -0.004 4.4e-01 NA 2.1e-01 NA 5.6e-01
9 GTEx Lung 0.0600 0.0282 8.8e-03 0.009 NA 0.005 NA 0.019 5.8e-02 NA 1.2e-01 NA 1.2e-02
10 GTEx Skin Sun Exposed Lower leg 0.0470 0.0220 9.2e-03 0.023 NA 0.003 NA 0.020 5.1e-03 NA 1.8e-01 NA 7.4e-03
11 GTEx Thyroid 0.0830 0.0310 1.2e-03 -0.001 NA 0.000 NA -0.002 4.3e-01 NA 3.5e-01 NA 5.6e-01
12 GTEx Uterus 0.2610 0.1130 7.6e-03 0.079 NA 0.004 NA 0.025 1.1e-02 NA 2.6e-01 NA 1.0e-01
13 GTEx Whole Blood 0.0650 0.0280 6.2e-03 -0.001 NA 0.013 NA -0.001 3.8e-01 NA 2.1e-02 NA 3.9e-01
14 NTR Blood 0.0534 0.0183 3.5e-05 0.023 0.016 0.018 0.019 0.018 4.3e-08 5.9e-06 1.1e-06 5.1e-07 1.1e-06
15 ROSMAP Brain Pre-frontal Cortex 0.4167 0.0463 0.0e+00 0.517 0.451 0.508 0.506 0.518 1.4e-77 2.2e-64 1.2e-75 2.5e-75 6.2e-78
16 YFS Blood 0.1874 0.0328 0.0e+00 0.096 0.169 0.167 0.167 0.154 8.1e-30 7.9e-53 3.3e-52 3.0e-52 4.4e-48
17 TCGA Breast Invasive Carcinoma 0.0541 0.0224 1.2e-07 0.015 0.033 0.029 NA 0.030 3.7e-04 1.8e-07 1.2e-06 NA 5.7e-07
18 TCGA Kidney Renal Clear Cell Carcinoma 0.0636 0.0302 4.0e-04 0.010 0.040 0.020 NA 0.015 2.4e-02 2.6e-05 2.2e-03 NA 7.5e-03
19 TCGA Brain Lower Grade Glioma 0.2484 0.0591 0.0e+00 0.292 0.308 0.304 NA 0.307 2.2e-33 1.6e-35 4.9e-35 NA 2.4e-35

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 0.6 0.9 4.9 0.4 0.3 0.1 0.2 0.3 1.2 -0.3 2.2 0.4 0.7 1.9 -0.4 1.8 1.0 0.3 0.6 0.8 0.1 0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 3.9 -0.7 -0.4 -0.5 -0.9 -0.6 -0.9 -0.7 0.1 -0.8 -0.4 1.6 -1.0 0.3 0.9 -0.4 2.0 -0.3 0.9 -1.0
Depressed Affect (Nagel 2018) 1.1 2.4 10.9 0.3 1.1 1.7 1.2 0.7 -0.6 1.5 -1.3 0.1 -1.3 -3.3 -1.1 -2.8 0.9 1.0 1.3 -2.4 -2.1 0.6
Depression (Nagel 2018) 0.9 1.3 7.5 0.3 1.0 1.2 0.1 0.3 0.0 1.0 -0.8 0.4 -0.3 -1.9 -2.7 -1.6 -0.5 1.0 0.8 -2.0 -0.3 0.4
Intelligence (Savage-Jansen 2018) 2.1 6.4 14.1 -3.3 -2.6 -2.5 -3.1 -2.7 -2.6 -2.5 -2.3 -3.4 -3.4 0.3 -0.3 -0.2 2.3 -2.5 3.7 0.5 0.6 -3.4
Neuroticism (Nagel 2018) 1.2 2.8 12.0 -0.1 0.6 0.7 0.3 -0.0 -1.4 1.0 -2.6 -0.2 -1.9 -3.0 -2.0 -3.5 0.0 0.5 1.2 -3.1 -1.6 0.0
Schizophrenia (2018) 0.7 1.5 4.8 -1.2 -0.8 -0.7 -1.3 -1.1 -2.2 -0.6 -1.6 -1.4 -1.1 0.5 -1.0 -1.1 0.5 -0.7 2.0 -1.0 1.0 -1.4
Schizophrenia vs Biploar Disorder 0.8 1.1 3.7 0.9 1.2 0.8 0.9 1.0 1.2 1.2 -1.9 0.8 0.5 -0.9 -0.5 -0.8 -1.3 1.2 0.1 -1.8 -0.1 0.8
Worry (Nagel 2018) 0.3 0.6 3.9 0.3 0.5 0.1 0.3 0.3 0.3 0.3 -2.0 0.1 0.2 -0.0 -0.3 -1.8 -0.5 0.4 0.4 -1.6 0.9 -0.1
Alzheimer’s Disease (in mother) 1.9 2.3 9.1 -2.0 -1.9 -1.3 -1.3 -1.8 -1.5 -3.0 1.0 -1.8 -1.6 0.6 0.5 1.0 0.9 -1.8 1.2 1.0 -0.6 -1.7
Alzheimer’s Disease (in father) 1.0 1.1 3.3 -1.2 -0.9 -0.3 -0.7 -0.8 -1.6 -0.6 -0.6 -1.5 -1.6 -0.8 0.2 -0.0 1.8 -0.9 1.4 0.7 -1.1 -0.9
Alzheimer’s Disease (including proxy) 2.6 3.7 9.4 -2.6 -2.2 -1.4 -1.7 -2.1 -2.0 -3.1 0.2 -2.8 -1.8 0.4 0.9 0.9 2.5 -2.3 2.0 1.9 -0.6 -2.1
Crohns Disease (2017) 11.2 24.6 51.4 6.7 6.7 5.8 6.2 6.7 6.5 6.3 0.6 5.8 7.2 1.3 -0.2 0.1 -1.0 6.7 -3.2 -1.3 1.7 5.6
Irritable Bowel Disease (IBD) 10.0 23.7 44.9 6.2 6.7 6.3 6.2 6.6 5.7 6.4 0.2 5.5 6.5 -0.3 -0.6 -1.0 -1.3 6.7 -3.4 -2.3 0.7 6.0
Ulcerative Colitis (UC) 4.5 8.4 16.1 3.4 4.0 4.0 3.6 3.7 2.4 4.0 -0.2 3.1 3.1 -1.6 -1.4 -1.5 -0.8 4.0 -2.5 -2.3 -0.6 3.9
Major Depression (MDD) 0.6 0.7 4.2 -0.2 0.4 0.4 1.0 0.6 0.6 0.6 -2.1 0.0 -0.3 -1.4 1.4 -0.5 -0.8 0.3 -0.5 -0.8 -0.9 -0.1
Reaction Time 0.6 1.2 7.2 1.0 1.0 1.0 0.2 0.5 0.4 1.5 -0.2 1.1 0.3 -1.2 -2.7 -0.4 -0.9 1.0 -1.3 -0.7 -0.5 1.3
Verbal and Numeric Reasoning (VNR) 1.2 2.9 6.0 -1.9 -1.5 -1.8 -2.2 -1.7 -2.0 -1.9 -1.9 -1.9 -2.4 0.3 -0.5 -1.4 0.7 -1.5 2.5 -1.1 0.9 -2.2
Breast Cancer 0.2 0.5 3.1 -0.3 -0.1 -0.2 -0.3 -0.1 -0.2 -0.3 -1.5 -0.6 0.5 1.3 0.0 -0.2 0.3 -0.1 0.6 0.6 1.8 -1.0
Ovarian Cancer 0.3 0.3 1.6 -0.5 -0.3 0.1 -0.3 -0.3 0.3 -0.6 -0.8 -0.4 0.1 0.5 0.0 1.3 1.0 -0.2 0.8 1.0 0.2 -0.3
Prostate Cancer 1.2 1.7 5.9 1.5 1.7 1.2 1.4 1.6 1.5 2.4 -0.3 1.2 1.5 -0.2 -0.7 -1.1 -1.3 1.7 -0.1 -1.5 0.6 1.2
Age at First Birth 0.4 0.6 2.6 -0.3 -0.5 -0.2 0.0 -0.3 0.0 0.1 0.4 0.2 -0.4 -0.8 0.8 0.9 1.4 -0.5 -1.5 0.9 -1.6 0.4
Bipolar Disorder (2011) 0.5 0.5 2.0 -0.5 -0.6 -0.6 -0.4 -0.4 0.7 -0.7 1.0 -0.4 0.9 1.4 0.6 1.0 0.3 -0.5 -0.0 0.7 1.1 -0.4
Body Mass Index (BMI) (2010) 0.6 0.8 1.8 1.0 1.0 0.8 0.9 1.0 0.9 1.4 -0.3 1.2 0.1 -0.5 -0.3 -0.9 -0.4 1.0 -0.6 -1.0 -1.0 1.2
Coronary Artery Disease (CAD) 1.9 2.3 5.1 1.9 1.5 1.8 2.2 1.9 1.3 1.3 -0.8 1.9 1.2 -0.8 0.5 -1.4 1.2 1.7 -0.4 0.1 -2.3 2.0
Crohns Disease (2012) 10.2 16.5 37.2 5.2 5.1 4.5 4.8 5.2 5.6 5.1 1.0 4.7 6.1 1.3 -0.1 1.0 -1.1 5.2 -4.0 -0.6 1.5 4.7
Mean Putamen Volume 0.4 0.5 1.9 0.5 0.2 0.6 0.2 0.3 0.2 0.8 0.3 0.8 1.2 -0.6 0.2 1.2 1.4 0.2 -0.9 0.8 0.1 0.7
Fasting Glucose 1.2 1.5 5.5 -1.1 -0.8 -0.3 -1.5 -1.4 -1.0 -0.9 0.4 -1.4 -0.8 0.8 -2.1 -0.3 2.3 -0.9 1.6 1.0 -0.1 -1.2
HbA1C 0.4 0.5 2.8 0.2 0.2 -0.4 0.2 0.5 -0.8 0.0 0.1 0.3 -1.4 0.7 1.3 -0.3 0.4 0.1 0.9 0.2 -1.7 0.3
HDL Cholesterol 0.3 0.5 4.7 -0.0 -0.4 -0.9 -0.8 -0.5 -0.3 0.1 0.4 0.3 0.1 0.8 -0.4 0.6 -2.2 -0.4 -1.2 0.3 0.1 0.0
LDL Cholesterol 0.5 0.8 3.6 1.1 1.1 0.7 0.7 0.9 0.8 0.8 0.2 0.9 -0.1 0.0 -0.9 -1.9 -0.1 1.2 0.1 -1.6 -0.6 0.9
Lupus 1.8 2.8 6.6 1.9 2.0 2.6 2.1 1.9 1.4 2.0 -0.5 1.3 1.4 -0.6 -0.2 -2.5 -0.3 2.1 0.6 -2.3 -0.2 1.9
Neuroticism (2016) 1.5 2.1 10.6 0.3 0.7 0.8 0.7 0.4 -0.7 1.1 -0.5 0.6 -1.6 -3.3 -1.8 -2.4 -1.0 0.7 -0.9 -2.2 -2.4 0.8
Primary Biliary Cirrhosis 1.2 1.7 4.8 1.0 1.6 2.1 1.1 1.3 0.9 1.4 -2.2 0.9 0.6 -1.1 -1.2 -0.9 1.3 1.6 0.1 -1.1 -0.7 1.6
Rheumatoid Arthritis 0.7 1.0 6.4 -1.1 -1.0 -1.3 -0.6 -0.5 0.4 -1.2 0.2 -1.0 0.1 0.7 2.5 0.7 -1.1 -1.0 -0.8 0.8 0.7 -0.9
Schizophrenia (2014) 0.2 0.4 1.7 -0.2 0.0 -0.2 -0.3 -0.1 -0.6 0.3 -0.8 -0.3 0.2 1.3 -0.3 0.3 0.3 0.1 1.0 -1.1 1.1 -0.6
Triglycerides 0.3 0.5 2.4 0.2 0.4 0.5 0.3 0.5 1.1 -0.2 -1.4 -0.2 1.6 0.4 0.4 -0.4 0.3 0.5 -0.4 0.4 1.2 0.1
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.8 -0.0 -0.1 -0.3 -0.4 -0.2 0.8 0.2 -0.2 -0.1 1.2 0.4 -0.2 0.7 -0.1 -0.0 -1.3 0.4 1.2 0.1
Ulcerative Colitis 5.2 7.5 13.9 3.2 3.7 3.7 2.9 3.4 3.1 3.7 -0.2 3.0 3.7 -1.1 -1.3 -0.9 -0.8 3.7 -2.7 -1.5 0.0 3.6
Blood Eosinophil Count 18.4 141.9 756.2 -1.1 -9.7 -7.7 -1.5 -6.6 -1.7 -8.6 27.5 2.6 1.6 9.6 8.8 22.3 14.4 -9.6 -0.3 24.0 -10.0 3.0
Blood Platelet Count 0.4 4.3 24.2 1.0 1.4 2.3 2.9 1.7 0.1 1.4 0.5 1.8 -1.2 -4.9 0.6 -0.0 0.1 1.5 -0.0 -1.2 -4.8 2.1
Blood Red Count 0.2 1.6 7.8 0.5 0.6 0.7 0.8 0.9 1.9 0.3 -1.6 0.0 2.4 1.9 1.5 0.6 -1.0 0.6 -0.7 0.3 2.8 -0.0
Blood White Count 0.3 2.5 18.4 -0.0 -0.4 0.4 1.5 0.1 -1.0 0.1 1.4 0.6 -2.0 -3.7 1.5 0.8 0.9 -0.2 -0.2 -0.0 -4.3 1.0
Heel T-Score 0.1 1.0 3.0 -0.7 -0.8 -1.4 -1.3 -0.6 0.4 -0.5 -0.9 -0.5 0.4 0.8 1.2 -0.5 -1.6 -0.8 -1.7 -0.2 1.5 -0.8
BMI 0.6 3.7 11.6 2.4 2.3 2.2 2.1 2.4 1.5 3.4 -1.8 2.3 1.3 -0.1 0.5 -0.5 -1.2 2.2 -1.9 -1.7 -0.0 2.4
Height 0.9 17.9 106.1 -4.0 -3.5 -3.4 -3.6 -3.7 -5.1 -4.7 -1.4 -5.1 -5.2 3.0 -0.3 -2.2 2.7 -3.6 10.3 0.5 1.2 -5.3
Waist Hip Ratio (WHR) 0.1 0.6 4.7 0.9 0.6 0.6 0.4 0.2 0.3 0.5 0.8 0.8 0.5 -0.6 -2.2 0.2 -1.1 0.6 -0.4 -0.0 -0.1 0.6
Systolic Blood Pressure 0.6 3.1 11.1 1.6 1.7 1.2 0.6 1.0 0.7 1.4 -0.6 2.4 0.9 -1.7 -3.2 -1.6 -2.2 1.7 -1.8 -3.3 -0.2 1.8
Smoking Status 0.9 2.0 8.1 -0.8 -1.2 -1.4 -1.3 -1.5 -1.2 -0.9 1.2 -1.4 -0.1 1.9 -0.8 1.6 0.5 -1.2 2.8 1.7 1.9 -1.5
Allergy or Eczema 11.9 31.2 130.0 4.9 1.4 3.0 4.8 2.2 4.1 2.8 11.4 6.0 4.1 0.1 0.6 8.4 7.1 1.6 -2.6 8.6 -8.3 7.0
Cardiovascular Disease 0.6 1.9 7.9 -1.4 -0.9 -0.8 -1.2 -1.2 -2.2 -0.2 -1.0 -1.0 -2.4 -2.8 -1.3 -1.2 -0.4 -0.9 -0.1 -0.8 -1.8 -0.6
Hypothyroidism (self reported) 0.9 2.1 4.3 1.8 1.8 1.7 1.7 1.6 1.0 2.0 1.3 2.1 0.5 -0.8 -1.1 -0.6 -1.3 1.9 -0.6 -1.7 -1.1 1.7
Respiratory disease 10.6 23.6 141.6 -0.3 -3.4 -1.4 -0.1 -2.7 -1.6 -1.7 11.9 1.4 -0.4 -0.8 0.9 8.2 6.7 -3.3 -0.9 9.1 -8.1 2.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.6 -1.1 -1.1 -0.7 -1.6 -1.2 -0.8 -0.9 0.1 -1.0 0.5 0.9 -0.2 0.7 -0.5 -1.1 -0.5 1.4 1.6 -0.8
Lung FEV1/FVC ratio 2.6 13.0 38.8 3.2 3.9 2.5 2.1 3.8 4.5 3.5 -5.7 1.9 4.6 4.7 0.7 -2.1 -3.9 3.8 -0.5 -3.0 6.2 1.2
Lung FVC 0.4 1.9 8.3 0.6 0.6 0.1 0.2 0.2 -1.6 -0.2 -1.2 0.0 -2.1 -0.8 -2.1 -2.9 0.2 0.6 2.6 -2.1 -1.3 -0.3
Neuroticism 0.9 2.2 8.9 0.5 1.2 1.6 1.5 1.0 -0.2 1.2 -1.9 0.3 -0.8 -2.6 -0.7 -3.0 1.0 1.2 1.4 -2.1 -1.7 0.6
Chronotype (morning person) 1.8 4.1 9.1 1.9 2.2 2.6 2.5 2.3 1.4 2.6 -0.6 1.8 -0.0 -2.7 -0.1 -3.0 -1.0 2.3 -0.1 -2.7 -2.0 2.4
Hair Pigment 0.2 7.1 16.0 2.9 2.8 2.8 3.3 2.9 2.7 4.0 -0.6 3.2 1.8 -3.4 0.2 -0.4 -2.2 2.8 -3.6 -1.9 -1.8 3.1
Tanning 0.7 8.3 21.4 -3.1 -3.5 -3.6 -3.6 -3.6 -4.3 -3.8 1.0 -2.7 -4.6 -0.4 -0.4 -0.6 0.6 -3.5 3.1 1.2 -1.4 -2.9
Hand grip strength (left) 0.4 1.0 2.3 -1.1 -1.2 -0.9 -0.7 -1.1 -0.7 -1.5 1.4 -1.3 -0.4 1.0 0.7 0.4 0.2 -1.2 1.3 0.5 0.7 -1.5
Number of treatments/medications taken 0.6 1.2 7.4 -0.7 -0.7 0.3 -0.3 -0.7 -0.5 0.3 0.7 0.1 -1.0 -2.7 -0.3 0.7 1.0 -0.6 -1.4 0.5 -2.7 0.4
Average weekly spirits intake 0.3 0.3 2.1 -0.5 -0.2 -0.2 -0.5 -0.4 0.5 0.1 0.0 -0.4 0.0 0.1 -1.3 0.8 -0.4 -0.1 1.4 0.3 0.1 -0.4
Sensitivity / hurt feelings 0.7 1.1 4.8 -1.3 -0.8 -0.7 -0.9 -0.9 -1.1 -0.4 -2.2 -0.8 -1.3 -1.9 0.1 -1.3 -0.2 -0.9 -0.2 -1.1 -0.4 -0.9
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.4 0.5 0.7 0.8 0.1 0.3 1.1 0.5 -1.0 0.6 0.8 -0.6 -1.6 -1.2 -0.4 0.7 -0.4 -0.3 0.5 0.4
Hearing difficulty/problems: Yes 0.7 1.1 6.0 -0.6 -0.4 -0.7 -1.3 -0.9 -0.2 -0.1 -1.1 -0.2 -1.7 -1.3 -2.4 -1.4 -1.0 -0.4 0.3 -0.8 -1.2 -0.6
Relative age of first facial hair 0.2 0.5 3.4 0.2 0.3 0.0 0.2 0.5 0.4 -0.1 0.2 0.4 0.9 0.4 0.5 0.9 -1.8 0.3 -1.2 -0.3 1.2 -0.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.4 1.1 1.2 1.3 1.5 1.5 1.2 1.1 0.7 1.2 0.6 -1.4 1.0 -0.2 -0.1 1.3 -1.2 0.0 -1.2 1.1
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.2 0.2 0.5 -0.2 -0.5 0.2 0.4 0.2 -0.7 0.1 0.2 0.4 -1.1 -0.1 -0.8 0.4 -0.1 -0.7 1.0 -0.3
Ever had hysterectomy (womb removed) 1.1 1.3 4.5 0.5 0.7 0.4 0.7 0.6 -0.3 1.4 -0.0 0.9 -1.2 -1.6 -0.9 -2.0 -1.5 0.7 -0.6 -1.7 -2.1 0.8
Systolic blood pressure, automated reading 0.3 0.8 3.8 0.9 0.9 0.2 0.4 0.6 0.8 1.1 -0.3 1.2 0.6 0.5 -0.7 -1.2 -1.4 0.8 -0.6 -2.0 0.7 0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.8 -0.9 -0.6 -0.6 -0.3 -0.5 -1.2 0.2 -1.1 -0.4 -0.9 -1.3 0.5 -1.3 -0.7 -0.6 -0.4 -0.8 -0.1 -0.5
Angina 1.0 1.3 6.2 0.6 0.8 0.9 0.2 0.3 0.1 1.3 0.3 0.7 -0.9 -2.3 -2.5 -1.7 0.0 0.9 -0.2 -1.0 -1.8 1.0
Medication for hormone replacement therapy 0.2 0.2 1.3 0.1 0.2 -0.1 -0.3 0.0 -0.3 0.5 -0.6 0.0 -0.0 -0.3 -1.1 -0.6 -0.6 0.2 0.4 -0.3 0.2 -0.4
Vitamin and mineral supplements 0.9 1.3 4.8 -0.4 -0.6 -0.4 -0.7 -0.7 0.8 -0.9 0.7 -0.8 1.3 2.1 0.0 2.2 1.2 -0.6 0.8 1.5 2.0 -0.4
Supplements: Zinc 0.4 0.4 2.2 -0.5 -0.6 -0.5 -0.1 -0.4 0.1 -0.4 0.0 -0.2 1.1 -0.2 1.0 0.2 -0.3 -0.6 -1.5 1.0 0.9 -0.3
Medication: Co-codamol 2.0 2.3 4.2 -2.1 -1.7 -1.8 -2.0 -2.0 -1.5 -1.5 -0.6 -2.0 -2.0 -0.1 -0.8 -0.0 1.3 -1.8 1.6 0.7 0.2 -2.0
Medication: Metformin 0.1 0.2 0.8 -0.7 -0.6 0.3 0.0 -0.5 -0.2 -0.3 0.4 -0.5 0.5 -0.6 0.3 0.9 0.0 -0.5 -0.3 0.6 0.2 0.0
Diabetes (father) 1.5 1.8 5.1 1.5 1.5 0.5 1.2 1.4 0.1 1.8 -0.6 1.9 -0.0 -0.9 -0.8 -1.2 -2.0 1.5 -1.4 -2.3 -0.2 1.7
Diabetes (mother) 2.4 3.0 5.4 2.2 2.1 2.3 2.1 2.2 1.9 1.8 -1.6 2.2 1.5 -0.3 -0.3 -1.7 -0.5 2.2 -1.4 -1.3 -0.7 2.3
Severe depression (siblings) 2.6 2.9 5.1 1.8 2.2 2.2 2.0 2.1 0.6 1.9 0.1 1.7 0.7 -2.3 -0.5 -1.6 -1.6 2.2 -1.1 -2.3 -1.1 1.8
Pack years adult smoking proportion 0.5 0.7 1.9 0.8 0.9 0.3 0.0 0.6 1.4 1.0 -1.0 1.1 0.9 -0.2 -1.0 -0.3 -0.6 0.9 -0.9 -0.9 1.2 0.7
Impedance of leg (right) 0.1 0.7 5.1 0.4 0.2 0.5 0.1 -0.0 0.6 -0.9 2.2 0.4 0.6 -1.0 -1.6 -0.1 0.2 0.2 -0.3 0.4 -1.3 0.8
Leg fat-free mass (left) 0.2 1.0 4.6 0.2 0.0 -0.3 0.2 0.2 -1.6 1.0 -2.0 -0.2 -1.5 1.2 1.1 -1.0 0.3 -0.0 2.1 -0.5 0.2 -0.4
Trunk fat percentage 0.3 1.2 2.7 1.4 1.1 1.0 1.2 1.2 1.4 1.6 -0.9 1.2 1.6 0.9 0.7 -0.4 -0.3 1.1 -0.9 0.0 0.9 1.4
Hand grip strength (right) 0.7 1.9 4.8 -1.3 -1.5 -1.6 -1.2 -1.6 -1.8 -2.0 1.4 -1.6 -1.8 0.3 -0.4 -0.5 -0.4 -1.5 2.2 -0.2 -0.2 -1.7
Townsend deprivation index at recruitment 1.7 2.4 8.0 1.2 0.7 0.6 1.3 1.1 1.5 0.8 2.0 1.3 2.4 0.8 1.1 2.8 1.5 0.7 -2.0 2.8 0.1 1.4
Current tobacco smoking 0.4 0.7 2.5 0.0 -0.3 -0.5 -0.2 -0.7 -0.4 -0.2 1.0 -0.5 0.2 0.5 -1.5 1.6 1.1 -0.4 1.4 1.4 0.8 -0.6
Average weekly fortified wine intake 2.3 2.7 9.7 1.3 1.7 1.5 1.4 1.6 1.5 1.8 0.1 1.5 0.5 -1.5 -0.3 -2.6 -3.1 1.7 -1.0 -2.4 -0.9 1.2
Maternal smoking around birth 0.5 0.7 7.0 -0.6 -0.5 -0.2 -0.4 -0.5 -0.9 0.1 -1.1 -0.7 -0.3 -0.5 0.1 0.7 2.6 -0.5 -0.4 1.2 -0.6 -0.1
Fed-up feelings 0.8 1.5 7.3 -0.6 -0.1 0.7 0.3 -0.1 -1.1 -0.1 -0.9 -0.7 -1.5 -2.7 -0.3 -2.2 2.1 -0.0 1.3 -0.7 -1.8 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 4.0 1.4 1.7 2.0 1.4 1.3 0.7 1.9 0.3 1.6 0.2 -1.7 -1.7 -0.8 1.0 1.7 -0.1 -1.1 -1.4 1.6
Relative age voice broke 0.5 0.8 3.0 0.4 1.1 1.5 0.9 1.2 0.4 0.5 -1.7 0.3 0.3 -1.4 0.0 -0.8 -0.6 1.2 -0.8 -1.1 0.0 0.5
Taking other prescription medications 1.9 3.0 22.3 -0.3 -0.4 0.8 0.6 -0.5 -0.9 0.4 2.4 0.8 -1.4 -4.1 -0.5 1.0 1.5 -0.4 -1.0 0.7 -4.7 1.3
Age when periods started (menarche) 0.6 1.4 6.7 0.7 1.0 1.6 1.5 1.0 1.1 0.8 -2.6 0.2 0.2 -1.2 -0.3 -0.6 1.5 1.1 1.8 -0.5 -0.8 0.5
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 7.4 -1.3 -1.0 -1.0 -1.2 -1.3 -2.4 -0.5 -0.2 -1.0 -2.7 -0.7 -1.2 -1.2 0.3 -1.0 0.7 -1.3 -1.2 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.9 -0.2 -0.1 -0.4 -0.3 -0.0 -0.2 0.3 -0.0 0.2 0.0 -0.2 0.6 -0.7 -0.9 -0.2 -0.9 -0.6 0.1 0.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.5 0.6 0.3 0.6 0.7 0.5 1.4 -0.2 1.0 0.4 1.6 0.6 0.7 1.2 -1.0 0.4 -0.5 0.9 0.5 0.5
Qualifications: CSEs or equivalent 1.9 2.5 9.5 -0.3 -1.4 -1.9 -1.4 -1.0 -0.5 -1.1 2.5 -0.4 0.7 2.8 1.3 2.6 0.8 -1.4 -1.0 3.1 1.3 -0.3
Serious illness, injury or assault to yourself 2.2 2.7 5.6 1.7 2.0 1.4 1.7 2.1 1.7 2.1 0.2 2.4 1.3 -1.3 0.2 -0.3 -2.2 2.0 -2.2 -1.5 -0.0 1.9
High blood pressure 0.5 1.3 3.1 -1.4 -0.9 -1.1 -1.5 -1.2 -1.2 -0.2 -1.6 -1.1 -1.4 -1.8 -0.8 -1.5 -0.6 -1.0 -0.9 -0.8 -0.3 -0.9
Hayfever, allergic rhinitis or eczema 8.9 19.2 94.9 3.0 0.1 1.7 3.0 0.8 2.1 1.1 9.7 4.0 2.2 -0.3 0.4 6.8 6.3 0.2 -1.6 7.3 -7.5 4.9
Multivitamins +/- minerals 0.6 0.8 2.9 -0.6 -0.6 -0.4 -0.3 -0.5 -1.6 -0.1 -0.1 -0.2 -1.5 -1.3 -0.1 -1.7 -0.6 -0.5 0.6 -0.3 -1.7 -0.2
Stomach or abdominal pain in last month 0.3 0.4 1.8 0.2 0.2 -0.0 0.4 0.2 0.1 -0.2 -0.3 0.7 -0.3 -1.3 0.0 0.8 -0.9 0.1 -0.4 -0.4 -1.3 0.9
Supplements: Glucosamine 0.6 0.8 2.0 -1.1 -1.0 -1.0 -1.1 -0.7 -1.4 -0.8 -0.4 -1.2 -1.4 -0.0 1.0 -0.5 0.1 -1.0 -0.3 0.3 0.0 -1.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 6.4 0.1 0.0 0.1 0.5 0.3 1.5 0.3 0.0 -0.0 1.8 1.2 1.4 2.5 0.3 -0.1 -0.5 2.2 1.0 -0.0
Medication: Atenolol 1.6 2.0 11.6 -1.1 -0.6 -0.8 -1.7 -1.1 -0.6 0.2 -3.4 -1.6 -0.7 0.5 -2.0 -1.1 -0.5 -0.5 0.6 -0.8 2.4 -1.8
Medication: Levothyroxine sodium 0.3 0.5 1.6 -0.5 -0.5 -1.2 -0.8 -0.8 -0.9 -0.1 0.9 -0.4 -0.9 0.7 -1.3 -0.0 -0.1 -0.5 0.7 0.4 0.0 -0.9
Sitting height 0.5 3.8 33.4 -1.0 -1.0 -1.1 -0.7 -0.9 -2.5 -0.9 -1.6 -1.8 -2.7 2.0 0.3 -1.0 1.8 -1.0 5.8 0.8 -0.4 -1.7
Chronic bronchitis/emphysema (father) 0.3 0.3 1.3 0.0 0.1 -1.0 -0.3 0.0 0.2 0.3 -1.1 0.2 -0.1 1.0 -0.6 0.6 -1.0 0.1 0.4 0.3 0.8 -0.4
High blood pressure (mother) 0.9 1.3 10.0 0.3 0.2 -0.1 0.6 0.8 1.2 0.1 -1.7 0.8 0.8 -0.2 2.5 -0.6 -0.9 0.2 -3.2 -0.2 0.6 0.7
Body mass index (BMI) 0.3 1.3 4.9 1.5 1.1 0.6 1.0 1.2 0.5 2.2 -1.1 1.6 0.4 0.4 0.6 -0.5 -1.0 1.1 -1.7 -0.8 -0.1 1.5
Impedance of leg (left) 0.1 0.7 5.0 0.4 0.3 0.6 0.3 0.1 0.8 -0.9 2.2 0.5 0.8 -0.8 -1.5 0.3 0.2 0.4 -0.2 0.5 -1.2 0.9
Leg predicted mass (left) 0.2 1.1 5.4 0.2 -0.0 -0.4 0.1 0.2 -1.6 0.9 -2.0 -0.2 -1.5 1.4 1.1 -0.9 0.3 -0.1 2.3 -0.4 0.3 -0.5
Trunk fat mass 0.1 0.5 1.8 0.9 0.5 0.3 0.7 0.7 0.3 1.2 -1.0 0.7 0.6 1.4 0.9 -0.5 -0.4 0.5 0.1 0.0 0.8 0.7
Waist circumference 0.1 0.4 1.7 0.9 0.5 -0.0 0.3 0.5 -0.2 1.3 -0.7 0.9 -0.4 0.6 0.0 -0.4 -1.3 0.4 -0.6 -0.6 0.0 0.7
Number of incorrect matches in round 0.8 1.4 6.6 -0.7 -1.1 -1.1 -1.3 -1.2 -0.6 -1.1 2.6 -0.5 0.8 0.5 -0.5 1.6 0.3 -1.0 -1.6 1.1 1.6 -0.8
Past tobacco smoking 0.7 1.2 3.7 0.7 1.0 1.4 1.3 1.1 1.4 1.1 -0.7 1.0 0.6 -1.7 0.1 -0.8 0.2 1.1 -1.9 -0.7 -1.0 1.4
Alcohol usually taken with meals 1.9 3.1 8.1 -2.1 -2.4 -2.3 -2.6 -2.1 -1.5 -2.8 0.6 -1.9 -0.5 1.2 0.9 -0.1 -1.2 -2.3 0.2 0.8 1.9 -2.4
Nervous feelings 0.4 0.7 4.1 -0.6 -0.4 -0.7 -0.9 -0.6 -1.0 -0.2 -2.0 -0.7 -0.3 0.8 -1.1 -0.1 0.4 -0.5 1.3 -0.4 1.1 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 4.1 0.4 0.6 0.8 0.6 0.4 -0.2 0.7 -1.4 0.7 -0.6 -2.0 -1.2 -1.1 0.2 0.6 -0.6 -0.8 -1.4 0.4
Hearing difficulty/problems with background noise 0.4 0.6 2.8 -0.6 -0.2 -0.7 -0.9 -0.5 -0.2 -0.6 -1.5 -0.2 -1.7 -0.2 -0.8 -0.6 -0.8 -0.3 1.0 -0.7 -0.7 -0.3
Hair/balding pattern: Pattern 2 0.5 0.6 2.2 -0.6 -0.8 -0.7 -0.8 -0.6 -0.0 -0.5 -0.6 -0.8 0.2 1.2 1.5 0.5 0.1 -0.8 0.1 0.9 1.4 -0.8
Had menopause 0.6 0.8 3.5 0.6 1.1 0.6 0.8 1.2 1.5 0.6 -1.9 0.5 0.8 0.0 1.0 -0.2 -1.1 0.9 -0.4 -0.6 0.5 0.2
Had other major operations 1.3 1.6 4.3 1.7 1.3 1.1 1.7 1.6 2.1 0.9 1.3 2.0 0.8 0.0 1.3 0.7 -1.0 1.3 -0.4 -0.1 -1.0 1.4
Forced vital capacity (FVC) 0.7 2.6 21.7 -0.1 -0.3 -0.7 -0.4 -0.6 -2.6 -1.4 -0.2 -0.7 -2.5 0.6 -1.6 -1.8 1.1 -0.4 4.7 -1.1 -1.0 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.5 0.1 0.3 0.5 0.1 0.4 -0.1 0.6 -0.2 0.3 0.1 -1.6 0.4 -1.3 -1.2 0.3 -1.0 -1.3 -0.4 0.6
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 4.3 -0.4 -1.0 -0.7 -0.6 -0.5 -0.6 -1.1 2.1 -0.4 -0.0 0.4 2.0 1.4 0.9 -1.1 -0.7 1.8 -0.0 -0.4
Qualifications: None of the above 0.3 0.7 2.0 0.9 1.0 0.8 0.8 0.7 1.3 0.4 -0.1 0.6 1.4 0.4 -1.1 0.5 0.1 1.0 0.8 0.1 0.8 0.7
Financial difficulties in last 2 years 0.8 1.0 2.3 0.9 0.8 1.2 1.1 0.7 0.7 1.3 -0.8 1.0 0.6 -0.7 -0.4 1.0 1.5 0.8 -0.9 1.2 -1.4 1.3
Mouth/teeth dental problems 0.8 1.3 2.6 -1.4 -1.4 -1.4 -1.3 -1.1 -0.7 -1.1 0.1 -1.5 -0.7 1.0 1.1 0.7 1.6 -1.3 0.6 0.8 0.7 -1.5
Heart attack 0.7 0.8 7.7 0.2 0.1 0.4 -0.5 -0.4 -0.9 -0.1 0.1 0.3 -1.0 -1.1 -2.8 -1.0 -1.0 0.2 0.2 -1.3 -0.8 0.1
Allergy 10.6 24.4 141.6 -1.9 1.6 -0.4 -1.8 0.7 -0.6 0.2 -11.9 -3.4 -1.2 0.0 -1.0 -8.2 -6.9 1.5 1.6 -9.2 8.8 -4.3
Pain all over the body in last month 0.2 0.2 1.1 0.3 0.3 0.2 0.2 0.3 0.5 -0.2 -0.6 0.6 0.3 -0.2 -0.0 -0.3 -0.1 0.3 -1.0 0.2 -0.6 0.6
Diabetes (self-reported) 0.3 0.4 1.9 -0.6 -0.4 0.3 -0.5 -0.5 -1.3 -0.0 -1.1 -0.1 -0.6 -1.4 -0.6 -0.8 0.1 -0.3 -0.2 -0.3 -0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 6.7 8.8 42.9 -1.0 -2.9 -2.3 -1.3 -2.2 -0.1 -2.3 5.8 -0.3 0.2 2.0 2.5 5.1 3.7 -3.0 -0.4 6.6 -2.4 0.0
Medication: Ramipril 0.4 0.5 1.8 -0.7 -0.5 -0.3 -0.6 -0.5 -0.5 -0.7 -1.4 -0.6 0.4 -0.3 0.2 -0.6 -1.0 -0.4 -1.3 -0.3 0.9 -0.4
Medication: Simvastatin 0.7 1.1 5.0 0.6 1.1 1.6 1.0 0.9 0.8 0.9 -0.9 0.7 0.1 -1.1 -0.9 -1.2 -0.5 1.2 -1.1 -2.2 -0.5 0.7
Fluid intelligence score 2.0 4.2 8.9 -2.6 -2.1 -2.3 -3.0 -2.4 -2.8 -1.9 -1.5 -2.7 -2.3 0.4 -1.1 0.0 1.6 -2.1 2.1 0.3 1.3 -2.7
Illnesses of siblings 0.5 0.7 4.3 0.3 -0.3 -0.2 0.2 -0.0 0.2 0.1 1.8 0.1 0.3 0.7 0.7 2.1 1.5 -0.3 -0.1 1.4 0.3 0.1
Neuroticism score 0.7 1.4 7.8 -0.2 0.3 0.8 0.6 0.2 -0.8 0.5 -2.4 -0.2 -1.0 -2.2 -0.4 -2.8 0.7 0.3 0.6 -1.8 -0.9 -0.1
Weight 0.1 0.5 2.0 0.3 0.0 -0.5 -0.0 0.0 -1.2 0.8 -1.2 0.2 -1.2 1.3 0.6 -0.8 -0.4 -0.1 1.4 -0.3 0.1 0.0
Impedance of arm (right) 0.2 1.0 6.2 -0.2 0.1 0.7 0.3 0.2 1.9 -1.3 0.7 -0.4 2.5 0.6 0.3 0.8 0.7 0.2 0.3 1.5 1.4 0.1
Arm fat percentage (right) 0.4 1.7 3.9 1.7 1.3 1.1 1.3 1.4 1.4 2.0 -0.5 1.7 1.7 1.1 0.6 -0.0 -0.8 1.3 -1.6 -0.3 0.6 1.9
Trunk fat-free mass 0.5 2.7 13.1 -0.7 -1.1 -1.7 -1.2 -1.1 -3.2 -0.3 -0.7 -1.0 -3.4 1.4 0.3 -0.8 0.2 -1.2 3.6 -0.4 -0.7 -1.4
Hip circumference 0.1 0.4 2.7 0.2 0.0 -0.4 0.2 0.3 -0.6 0.3 -0.6 0.2 -0.9 1.2 1.6 -0.3 -0.9 -0.0 0.5 -0.5 0.1 0.1
Time employed in main current job 1.0 1.1 2.8 1.4 1.1 0.4 0.7 0.8 1.7 1.1 1.0 1.4 1.3 0.5 -0.9 0.9 -1.5 1.0 -1.3 0.4 0.2 1.0
Alcohol intake versus 10 years previously 0.5 0.7 1.7 -0.8 -0.6 -0.8 -1.0 -0.8 -1.2 -0.2 -0.3 -1.1 -1.1 -1.1 -1.0 -0.2 0.8 -0.5 0.9 -0.3 0.4 -1.3
Father’s age at death 0.5 0.7 4.5 -0.5 -0.1 -0.1 -0.0 -0.1 1.0 -0.1 -1.5 -0.2 0.0 -0.0 0.6 0.4 -2.1 -0.1 -1.1 -1.1 1.2 -0.8
Worrier / anxious feelings 0.2 0.4 2.3 -0.7 -0.5 -0.5 -0.4 -0.5 -0.6 -0.9 -1.5 -0.7 -0.3 0.4 0.2 -0.5 0.2 -0.6 0.8 -0.3 0.7 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 4.8 1.1 1.2 1.2 1.2 1.1 0.1 1.5 -1.6 1.2 -0.4 -2.2 -0.9 -0.8 -0.2 1.1 -0.8 -0.4 -1.8 1.1
Falls in the last year 0.9 1.2 2.8 1.3 1.3 1.5 0.7 1.0 0.7 1.3 0.0 1.4 0.4 -1.6 -1.7 -0.1 -0.0 1.4 -0.9 -1.3 -1.1 1.1
Hair/balding pattern: Pattern 3 0.8 1.1 3.5 -0.8 -1.0 -0.8 -0.8 -1.1 -0.6 -1.1 1.5 -1.0 0.6 1.5 -0.2 0.6 1.9 -1.0 0.0 1.6 1.1 -1.0
Number of live births 0.2 0.3 2.5 -0.2 0.1 -0.6 -0.5 -0.2 -0.0 -0.2 0.1 -0.4 -0.7 0.8 -0.8 -0.3 -0.6 -0.1 1.6 -0.1 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 12.3 1.4 1.3 0.4 0.8 1.1 -1.1 0.4 -2.2 0.6 -0.9 1.1 -1.1 -2.5 -0.3 1.3 3.5 -2.1 0.1 0.5
Pulse rate 0.3 0.5 6.0 0.0 -0.1 -0.4 0.5 0.5 0.4 0.5 -0.6 0.2 -0.1 0.5 2.5 1.3 0.4 -0.1 -0.2 0.8 -0.4 0.3
Happiness 0.2 0.2 1.9 -0.2 -0.4 -0.6 -0.4 -0.2 -0.3 0.2 0.3 -0.2 -0.5 0.3 0.9 -0.3 -0.3 -0.4 -1.4 0.1 -0.2 -0.4
Noisy workplace 1.3 1.7 4.0 1.5 1.2 0.9 1.7 1.3 1.6 1.6 1.0 2.0 0.9 -0.8 0.4 0.1 0.4 1.2 -1.9 0.1 -1.3 1.8
Qualifications: A levels/AS levels or equivalent 1.0 2.2 5.4 -2.1 -1.7 -0.9 -1.7 -1.5 -1.8 -1.5 0.2 -2.3 -1.1 0.5 0.9 1.1 1.6 -1.6 1.4 1.7 0.6 -2.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.2 0.2 0.3 -0.3 0.2 0.2 -0.0 0.9 -1.1 0.2 -1.0 -0.3 -0.6 0.3 0.0 0.3 0.1 -0.5 -0.6 -0.1
Mouth/teeth dental problems: Dentures 0.6 0.9 2.4 -1.2 -1.3 -1.5 -1.2 -1.3 -0.3 -1.4 0.3 -1.0 -0.9 0.4 0.2 0.4 -0.0 -1.3 0.6 1.3 -0.2 -1.0
Asthma 9.6 19.0 136.9 0.4 -2.5 -0.7 0.3 -1.8 -0.0 -1.5 11.7 2.0 0.7 -0.2 1.2 7.0 5.0 -2.5 -1.6 8.1 -7.0 2.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 3.0 -0.1 0.1 -0.3 0.1 0.4 -1.5 0.1 -1.3 0.1 -1.5 -1.7 0.4 -0.6 -1.5 0.1 -0.3 -0.7 -1.1 -0.2
Medication: Cholesterol lowering 0.5 0.7 3.2 -0.1 0.1 0.5 -0.3 -0.4 -0.8 0.4 -0.2 0.2 -1.0 -1.8 -1.8 -1.2 -0.4 0.1 -0.2 -1.6 -1.0 0.2
Depression (self-reported) 0.1 0.1 0.5 -0.2 -0.1 -0.0 -0.1 0.0 0.1 0.3 0.0 -0.2 -0.3 -0.4 0.7 -0.5 -0.6 -0.1 0.2 -0.5 0.1 -0.3
Medication: Lansoprazole 0.5 0.6 2.4 -0.1 -0.1 -0.4 -0.0 0.0 0.4 0.3 0.4 -0.1 1.3 0.7 0.8 1.1 -0.7 -0.2 -1.1 1.5 1.5 0.1
Prospective memory result 1.1 1.4 4.0 1.2 1.3 1.3 1.4 1.5 2.0 0.8 0.6 1.3 1.8 0.2 1.1 1.6 0.9 1.3 -0.0 0.2 0.3 1.4
Lung cancer (father) 0.7 0.8 2.3 -0.7 -1.0 -1.2 -0.8 -0.7 -1.0 -1.4 -0.2 -0.2 -1.5 -0.4 0.8 -0.6 -1.0 -1.0 -0.9 -0.1 -1.0 -0.6
Illnesses of mother 1.0 1.2 6.5 0.3 0.1 -0.3 -0.1 -0.3 -1.2 0.1 2.6 0.0 -0.8 0.7 -2.3 1.4 0.4 0.1 2.4 0.3 -0.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 9.9 0.8 0.9 -0.1 0.4 0.8 -0.6 0.2 -2.4 -0.1 -0.7 1.4 -0.5 -1.9 0.0 0.8 3.1 -0.9 0.3 -0.3
Pulse wave Arterial Stiffness index 0.2 0.2 1.3 0.2 -0.2 -0.4 -0.1 -0.2 -0.3 0.1 1.2 0.0 0.3 0.8 -0.5 1.0 -0.5 -0.2 0.3 -0.3 0.7 -0.3
Impedance of arm (left) 0.2 0.9 4.9 -0.3 0.1 0.5 0.3 0.1 1.5 -1.3 0.8 -0.6 2.2 0.4 0.1 0.5 1.0 0.1 0.8 1.6 1.4 -0.1
Arm fat mass (right) 0.3 1.0 3.6 1.5 1.1 0.8 1.0 1.2 0.5 1.9 -1.0 1.4 0.6 1.0 0.6 -0.5 -0.8 1.0 -0.6 -0.5 0.1 1.5
Trunk predicted mass 0.5 2.9 13.8 -0.8 -1.2 -1.8 -1.3 -1.2 -3.3 -0.4 -0.7 -1.1 -3.5 1.5 0.2 -0.8 0.2 -1.3 3.7 -0.3 -0.7 -1.4
Standing height 0.7 6.5 44.0 -2.0 -2.1 -2.3 -2.0 -2.1 -3.4 -2.6 -0.2 -2.7 -3.2 2.3 -0.1 -1.0 1.1 -2.2 6.6 0.7 0.5 -2.9
Length of working week for main job 0.2 0.2 0.8 0.3 -0.2 -0.4 0.1 -0.1 -0.9 0.4 0.6 0.5 -0.4 -0.4 0.2 0.4 0.9 -0.2 0.5 0.4 -0.9 0.5
Exposure to tobacco smoke at home 0.3 0.4 1.5 -0.4 -0.6 -0.9 -0.7 -0.7 -0.2 -0.7 0.2 -0.0 -1.2 0.3 -0.2 -0.7 -0.6 -0.6 0.6 -0.5 -0.2 -0.4
Breastfed as a baby 0.4 0.6 1.5 0.9 1.2 0.9 0.4 1.0 0.7 0.8 -0.7 0.6 0.5 -0.3 -1.0 0.4 1.0 1.1 0.5 -0.2 0.2 0.2
Tense / ‘highly strung’ 0.4 0.6 3.7 0.6 0.3 -0.2 0.1 0.2 0.3 0.7 0.3 1.0 0.3 -0.2 0.1 -1.5 -1.9 0.3 -1.1 -1.1 0.4 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.3 -1.9 -1.7 -1.5 -1.6 -1.7 -1.2 -1.6 -2.1 -2.0 -0.8 -0.3 0.7 -1.0 0.0 -1.8 0.5 1.0 1.1 -1.9
Hair/balding pattern: Pattern 4 0.3 0.8 3.8 0.4 0.5 0.1 0.2 0.4 0.2 0.7 -1.3 0.4 0.6 -1.8 -0.6 -0.7 -2.0 0.6 -1.4 -0.8 0.5 0.3
Birth weight of first child 1.4 2.5 8.3 -1.5 -1.6 -1.2 -1.7 -1.8 -1.4 -2.0 0.2 -2.0 -1.3 1.9 -0.5 -0.0 1.9 -1.6 2.9 1.1 0.6 -1.8
Peak expiratory flow (PEF) 0.3 0.7 1.6 1.2 1.0 0.8 1.3 1.2 -0.0 0.8 0.2 0.9 -0.1 -0.3 0.1 -0.8 0.3 1.1 1.0 -1.1 -1.0 1.0
Pulse wave reflection index 1.4 1.7 8.0 1.8 1.4 1.5 1.5 1.2 0.9 1.1 2.8 1.3 2.1 0.9 -1.0 0.4 -0.5 1.4 0.1 0.0 0.8 1.1
Ever highly irritable/argumentative for 2 days 2.1 2.5 4.5 1.9 1.9 1.9 1.9 1.9 1.7 1.4 0.6 1.9 1.0 -2.0 0.1 -1.1 -1.0 1.9 -1.6 -0.7 -1.5 2.1
Loud music exposure frequency 0.6 0.6 3.7 0.1 -0.4 -0.5 0.1 -0.3 -0.1 -0.5 1.3 0.5 0.8 1.5 0.1 1.9 0.1 -0.3 0.1 1.5 0.4 0.0
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.6 -1.6 -1.4 -0.5 -1.3 -1.0 -0.9 -1.0 0.4 -1.6 -0.6 0.1 1.4 0.2 1.6 -1.3 0.3 1.0 0.1 -1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.5 1.0 0.9 1.1 0.9 0.9 -0.3 0.8 0.9 0.9 0.3 -0.3 -0.0 -1.1 -0.9 0.9 0.5 -0.6 -0.7 1.2
Blood clot in the leg (DVT) 0.4 0.5 4.1 0.0 0.2 -0.5 -0.7 -0.1 -0.8 0.5 -0.2 0.2 -0.4 -0.2 -1.2 0.6 -2.0 0.2 -0.0 -1.1 0.5 -0.2
Medication: Paracetamol 1.2 2.0 6.7 1.1 1.3 0.9 1.3 1.3 -0.7 1.7 -0.5 1.6 -1.1 -2.6 -0.3 -1.8 -0.6 1.3 -1.4 -1.3 -2.2 1.5
Headache pain in last month 0.1 0.1 1.3 0.2 0.1 0.3 0.0 0.1 0.3 0.7 -0.3 0.2 0.2 -0.5 -0.3 -0.2 0.1 0.2 -1.1 0.4 -0.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 4.0 0.7 0.3 -0.1 0.7 0.7 0.5 -0.1 0.8 0.2 0.7 2.0 1.7 1.0 0.6 0.2 0.4 1.4 0.5 0.2
Glaucoma (self-reported) 0.9 1.1 6.7 0.5 0.5 0.7 0.9 0.7 0.5 1.2 0.3 1.0 0.6 -1.7 1.0 -0.9 -1.4 0.5 -2.6 -0.6 -0.7 0.8
Gout (self-reported) 0.5 0.7 4.4 -0.5 -0.0 -0.4 0.5 0.4 0.5 -0.5 -1.8 -0.5 0.6 0.4 2.1 -1.2 -0.4 -0.0 0.6 -0.0 1.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.5 0.9 1.0 0.7 0.9 0.8 0.3 1.2 1.9 1.3 -0.3 -0.7 -1.2 -0.3 -0.5 1.1 -0.2 -1.0 -1.4 0.9
Medication: Amlodipine 0.1 0.2 1.7 -0.3 -0.3 -0.4 0.2 0.0 -0.1 0.2 -0.1 0.2 -0.2 -0.1 1.3 -0.3 -0.7 -0.3 -0.1 -0.5 -0.1 -0.0
Medication: Ventolin 100micrograms inhaler 5.9 7.6 42.1 0.0 -1.9 -0.9 -0.2 -1.4 0.3 -0.8 6.5 1.1 1.3 1.4 0.9 5.5 3.0 -1.8 -2.1 5.7 -2.8 1.5
Birth weight 1.6 3.5 18.7 -2.0 -1.7 -1.4 -1.7 -2.0 -2.5 -1.3 -0.7 -2.3 -1.5 1.1 -0.9 0.9 1.5 -1.7 4.3 0.5 1.1 -2.5
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.1 1.2 1.2 1.2 1.3 1.2 0.6 1.4 -0.1 1.6 0.3 -2.0 -0.4 -0.7 1.3 1.2 -1.0 -0.7 -1.9 1.7
High blood pressure (siblings) 0.4 0.5 3.9 -0.1 0.4 0.8 0.1 0.4 0.3 0.3 -2.0 -0.1 0.8 -0.4 0.4 -1.3 -1.0 0.5 -0.8 -0.2 0.4 0.1
Forced vital capacity (FVC), Best measure 0.6 2.2 18.0 -0.5 -0.5 -1.0 -0.7 -0.8 -2.0 -1.2 -0.6 -1.1 -2.2 0.9 -1.4 -1.4 1.2 -0.6 4.2 -0.2 -0.8 -1.3
Body fat percentage 0.4 1.4 3.3 1.6 1.2 1.0 1.2 1.3 1.3 1.8 -0.3 1.6 1.4 0.7 0.8 -0.3 -0.7 1.1 -1.6 -0.2 0.5 1.7
Leg fat percentage (right) 0.4 1.4 5.1 1.6 1.0 0.6 1.1 1.1 1.0 1.9 0.3 1.8 0.7 0.3 0.4 -0.4 -1.3 1.0 -2.2 -0.6 -0.3 1.8
Arm fat-free mass (right) 0.4 2.1 9.9 -0.5 -0.8 -1.3 -0.8 -0.8 -3.0 0.2 -1.3 -0.7 -3.1 0.8 0.2 -1.3 0.1 -0.9 2.9 -0.6 -0.9 -1.0
Exposure to tobacco smoke outside home 0.3 0.3 1.1 0.4 0.3 1.0 0.8 0.4 -0.1 0.8 0.2 0.3 0.3 -0.5 0.9 0.6 0.3 0.3 -0.9 0.4 -0.8 0.7
Comparative body size at age 10 0.3 0.8 4.0 -0.5 -0.7 -0.7 -0.8 -0.5 -0.2 0.5 -2.0 -0.5 0.4 1.3 1.0 -1.3 -0.4 -0.7 -0.7 -0.1 1.6 -0.5
Number of full brothers 2.0 2.5 8.1 1.4 1.4 1.3 1.5 1.0 -0.1 1.9 0.8 1.7 -1.3 -2.2 -2.4 -1.2 -0.3 1.5 0.2 -2.2 -2.9 1.8
Worry too long after embarrassment 0.7 1.2 5.7 -0.4 -0.1 0.1 -0.1 -0.2 -1.4 -0.3 -2.4 -0.7 -1.3 -0.8 -0.7 -2.4 1.3 -0.1 1.6 -1.0 -0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.7 -1.1 -0.9 -0.2 -0.5 -0.8 -0.6 -1.0 -1.3 -1.1 -0.2 -0.4 0.8 0.2 0.3 -0.9 0.8 0.9 0.2 -1.1
Wheeze or whistling in the chest in last year 5.2 9.3 49.7 -0.5 -2.3 -1.2 -0.5 -1.6 -0.5 -1.2 7.0 0.8 -0.5 -1.3 1.5 5.2 3.6 -2.2 -1.7 5.9 -5.1 1.2
Number of children fathered 0.7 0.8 4.8 -0.5 -0.4 -0.1 0.0 -0.0 1.2 -0.7 0.3 -0.5 0.8 0.8 2.1 -0.2 -2.2 -0.4 -0.5 -0.2 1.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.5 -1.2 -0.8 -0.0 -0.7 -0.7 -0.7 -1.6 -1.5 -1.4 0.3 -0.0 0.7 0.6 1.0 -0.7 1.1 1.0 1.0 -1.1
Age at first live birth 1.1 1.9 3.7 -1.9 -1.8 -1.1 -1.7 -1.7 -0.9 -1.9 -0.5 -1.8 -1.0 0.2 0.6 1.2 1.5 -1.8 1.5 1.0 0.5 -1.6
Pulse wave peak to peak time 0.2 0.2 1.2 -0.2 0.1 0.3 0.0 0.2 0.1 -0.2 -1.1 -0.1 -0.4 -0.6 0.4 -1.0 0.5 0.1 0.3 0.3 -0.7 0.1
Health satisfaction 0.9 1.2 4.0 -0.4 -0.5 -1.3 -0.6 -0.8 -1.4 0.0 1.2 0.4 -1.9 -1.3 -1.0 -0.7 -2.0 -0.5 -0.7 -1.7 -1.4 -0.1
Shortness of breath walking on level ground 1.4 1.7 9.3 0.6 0.4 -0.6 0.1 0.4 -0.0 0.2 1.2 1.2 -1.0 -2.0 -0.1 -1.7 -3.0 0.4 -2.2 -1.9 -1.2 0.6
Qualifications: College or University degree 1.5 4.7 12.8 -3.2 -2.8 -2.0 -2.6 -2.7 -2.5 -2.3 -1.0 -3.1 -1.9 0.0 0.6 -0.3 0.9 -2.7 1.8 1.0 1.5 -3.6
Eye problems/disorders: None of the above 0.9 1.0 7.5 1.3 1.0 0.7 0.1 0.5 0.6 0.4 0.3 0.8 1.3 0.7 -2.7 1.1 0.8 1.0 0.4 0.6 0.6 1.0
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.9 1.8 1.4 1.4 1.6 1.4 1.1 0.9 1.4 1.8 2.0 -0.3 -0.1 0.7 0.1 1.4 -0.8 1.2 -0.2 1.8
Emphysema/chronic bronchitis 2.3 2.6 6.7 -1.6 -2.0 -1.2 -1.5 -2.0 -1.8 -1.7 0.0 -1.5 -1.1 -0.1 -0.5 2.3 2.6 -1.9 1.3 2.4 -0.8 -1.4
Medication for pain relief, constipation, heartburn 1.2 2.1 10.7 -0.4 -0.7 -0.5 -0.1 -0.3 1.5 -1.1 1.7 -0.8 1.7 3.3 2.1 1.1 1.5 -0.7 1.6 1.7 2.1 -0.5
Neck or shoulder pain in last month 0.1 0.1 0.6 -0.3 -0.3 -0.2 -0.3 -0.2 0.4 0.0 -0.2 0.1 0.3 -0.1 0.8 -0.3 -0.4 -0.3 -0.3 0.7 -0.0 0.0
Medication: Blood pressure 0.1 0.2 1.2 -0.4 -0.3 -0.2 -0.6 -0.3 -0.1 -0.0 -0.6 0.0 -0.2 -1.1 -0.3 -0.7 -0.9 -0.2 -0.4 -0.6 0.1 -0.1
Angina (self-reported) 0.8 1.0 5.9 0.4 0.6 0.8 0.0 0.1 -0.1 1.0 0.6 0.5 -0.8 -2.0 -2.4 -1.3 0.1 0.6 -0.3 -0.8 -1.6 0.8
Migraine (self-reported) 0.5 0.6 1.9 -1.4 -0.9 -0.0 -0.7 -0.7 0.2 -0.5 -1.1 -1.3 -0.3 -0.8 1.1 0.4 0.5 -0.9 0.2 0.6 0.0 -1.2
Medication: Ibuprofen 1.2 1.4 5.6 0.5 1.0 0.5 0.4 1.1 -1.1 1.1 -2.4 0.5 -1.4 -2.0 -0.1 -1.3 -1.8 0.9 -0.3 -1.8 -1.1 0.4
Medication: Allopurinol 0.8 1.0 4.6 0.6 1.1 1.1 1.4 1.2 0.4 1.0 -2.1 0.5 0.2 -1.1 0.6 -1.6 1.0 1.1 0.1 -1.1 -0.6 0.6
Medication: Omeprazole 1.6 1.9 9.9 0.8 1.2 1.0 0.9 0.9 0.5 1.6 -1.6 1.1 -0.8 -3.1 -1.1 -1.2 -0.3 1.2 -0.5 -1.7 -2.2 1.1
Medication: Seretide 50 evohaler 4.2 4.8 24.1 -1.4 -2.5 -1.8 -1.2 -2.1 -0.3 -1.9 4.9 -0.8 0.6 0.2 1.2 3.8 1.7 -2.4 -1.7 4.1 -1.0 -0.6
Mean time to correctly identify matches 0.7 1.4 6.2 1.0 1.1 1.0 0.3 0.6 0.9 1.4 -0.5 1.0 0.8 -1.5 -2.5 -0.6 -1.4 1.1 -1.9 -1.1 0.3 1.0
Heart disease (mother) 0.8 1.0 5.4 0.3 0.4 0.3 0.2 0.4 0.9 1.1 -0.7 0.5 0.5 -1.4 0.6 -2.3 -1.2 0.4 -2.2 -0.9 0.6 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 5.5 2.2 2.1 1.6 1.5 1.8 0.8 1.5 1.1 2.1 0.8 -1.3 -1.6 -0.5 -1.4 2.1 -0.7 -1.9 -1.0 2.3
Whole body fat mass 0.1 0.6 2.2 1.1 0.7 0.5 0.8 0.9 0.2 1.5 -0.9 1.0 0.4 0.9 0.9 -0.6 -0.5 0.7 -0.4 -0.2 0.3 1.0
Leg fat mass (right) 0.2 0.7 3.0 1.1 0.7 0.4 0.8 0.9 0.3 1.7 -0.9 1.2 0.1 0.7 1.0 -0.7 -0.6 0.7 -0.9 -0.5 -0.0 1.1
Arm predicted mass (right) 0.3 1.7 8.4 -0.3 -0.7 -1.1 -0.6 -0.6 -2.8 0.4 -1.1 -0.5 -2.9 0.9 0.4 -1.1 0.2 -0.7 2.9 -0.5 -0.9 -0.8
Pulse rate, automated reading 0.2 0.5 2.8 -0.2 -0.3 -0.0 0.3 0.1 -0.4 -0.0 -0.1 -0.1 -1.0 -1.0 1.4 0.5 0.7 -0.3 1.0 1.2 -1.7 0.4
Alcohol intake frequency. 0.8 1.9 5.3 1.7 1.8 1.2 1.1 1.3 1.3 2.1 -0.0 1.8 0.5 -0.6 -2.3 -0.3 -0.7 1.8 -1.0 -1.1 -1.0 1.8
Comparative height size at age 10 0.1 0.7 4.8 0.6 0.3 0.4 0.4 0.1 -0.6 0.4 0.6 0.4 -1.0 0.2 -1.4 -1.2 0.1 0.3 2.2 -1.2 -1.0 0.1
Number of full sisters 0.4 0.5 1.6 0.3 0.6 0.6 0.4 0.4 -0.5 0.4 -0.9 -0.0 -0.9 -0.4 -1.2 -1.0 0.3 0.6 1.2 -0.8 -0.7 0.2
Suffer from ‘nerves’ 0.5 0.7 2.3 -0.5 -0.5 -0.6 -0.4 -0.6 -1.4 -0.3 -1.4 -0.9 -0.7 0.8 0.1 -1.5 0.6 -0.6 1.0 -0.5 1.1 -0.8
Overall health rating 0.9 1.8 8.4 0.8 0.9 0.7 0.6 0.4 0.1 2.1 -0.5 1.2 -0.3 -2.9 -2.3 -0.7 -0.3 0.9 -2.2 -1.9 -1.2 1.0
Chest pain or discomfort 1.8 2.6 11.4 -0.8 -1.5 -1.0 -0.8 -1.5 -1.6 -1.5 3.4 -0.2 -1.9 -1.5 -1.0 1.2 1.0 -1.4 -0.6 1.7 -3.3 0.2
Had major operations 0.1 0.1 0.5 0.0 0.1 0.3 0.3 0.1 -0.2 0.5 -0.7 0.0 0.1 -0.6 -0.2 -0.3 -0.4 0.1 -0.2 0.1 -0.3 0.6
Age at last live birth 1.1 1.6 7.7 -1.5 -1.3 -0.4 -0.7 -1.1 -0.4 -1.3 0.4 -1.7 -0.6 0.9 1.2 0.6 2.8 -1.3 2.0 1.3 -0.1 -0.9
Family relationship satisfaction 0.5 0.7 4.0 0.4 0.2 0.3 0.9 0.7 0.4 0.6 0.4 0.6 -0.4 -0.6 2.0 -0.4 -0.6 0.2 -1.6 -0.0 -1.3 0.9
Leg pain on walking 0.5 0.6 2.3 0.0 -0.2 -0.5 -0.4 -0.2 -0.8 0.2 0.4 0.4 -1.2 -1.2 0.2 -1.1 -0.9 -0.2 -1.5 -1.3 -0.6 -0.0
Qualifications: NVQ or HND or HNC or equivalent 4.7 5.7 12.7 3.0 2.8 2.3 3.2 3.1 2.3 3.0 0.6 3.1 1.8 -0.8 0.9 0.1 -1.3 2.8 -3.6 -1.0 -1.8 3.2
Commuting to job workplace: Car/motor vehicle 0.2 0.3 2.2 -0.1 -0.1 -0.1 0.2 -0.1 0.1 -0.3 -0.4 0.1 -0.6 -0.7 -0.3 -1.5 -0.3 -0.0 0.7 -0.9 -0.6 0.1
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 4.7 -0.9 -0.9 -0.7 -0.7 -0.9 -1.1 -1.7 1.2 -1.0 -0.8 0.6 0.3 -2.2 -0.8 -0.9 1.9 -1.5 0.7 -1.0
Medication: Aspirin 0.7 0.9 2.8 1.1 1.0 1.2 0.6 0.7 0.6 1.1 -0.5 1.2 0.1 -0.9 -1.7 -0.5 -1.1 1.0 -1.0 -1.3 -0.4 0.8
Supplements: Vitamin C 2.7 3.2 8.7 1.6 1.9 1.5 1.9 2.0 1.5 1.7 0.1 2.0 0.7 -2.3 1.0 -1.4 -2.4 1.8 -3.0 -2.1 -1.2 1.9
Knee pain experienced in last month 1.0 1.6 4.8 1.1 1.2 1.5 1.8 1.7 1.3 1.1 -2.2 0.9 0.9 -1.0 2.0 -1.4 -0.1 1.2 -0.9 -0.1 -0.5 0.8
Hypertension (Self-reported) 0.5 1.4 3.1 -1.6 -1.1 -1.2 -1.6 -1.3 -1.4 -0.4 -1.8 -1.4 -1.5 -1.7 -0.4 -1.4 -0.3 -1.2 -0.6 -0.5 -0.2 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 0.6 0.4 0.5 0.8 0.6 0.2 0.6 0.3 0.6 0.8 0.4 0.9 0.4 -0.3 0.4 -1.2 0.2 0.1 0.7
Illnesses of father: Heart disease 0.4 0.5 4.4 0.4 0.6 0.3 -0.3 0.1 0.2 0.1 -1.5 0.4 0.0 -0.4 -2.1 -0.4 -0.2 0.6 0.2 -0.7 -0.3 0.5
Illnesses of siblings: Diabetes 0.2 0.3 2.9 -0.2 0.3 0.1 0.1 0.4 -0.4 -0.5 -1.7 -0.4 -0.6 -0.1 0.2 -0.6 0.1 0.3 0.9 -0.5 0.1 -0.4
Smoking status: Previous 0.5 0.7 5.2 -0.1 -0.5 -1.0 -0.7 -0.3 -0.4 -0.6 0.9 -0.4 0.1 2.3 0.9 0.3 -0.2 -0.6 1.3 0.9 0.9 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.4 1.2 0.8 1.0 1.3 1.0 0.3 1.3 0.9 1.0 -0.3 0.1 -0.2 -0.3 1.2 0.9 1.2 0.4 -2.1 1.0
Whole body fat-free mass 0.3 1.9 10.2 -0.4 -0.7 -1.2 -0.7 -0.6 -2.7 0.2 -1.3 -0.7 -2.8 1.3 0.6 -0.9 0.3 -0.8 3.2 -0.4 -0.5 -1.0
Leg fat-free mass (right) 0.2 1.1 6.7 0.1 -0.0 -0.3 0.2 0.2 -1.6 0.9 -2.1 -0.3 -1.6 1.3 1.1 -0.8 0.5 -0.1 2.6 -0.4 0.2 -0.5
Arm fat percentage (left) 0.3 1.4 3.5 1.6 1.2 0.9 1.2 1.2 1.1 1.9 -0.3 1.5 1.6 1.2 0.7 0.0 -0.7 1.1 -1.3 0.0 0.8 1.6
Average weekly red wine intake 1.3 2.0 4.3 -1.6 -1.6 -1.0 -1.6 -1.5 -1.9 -2.1 0.6 -2.0 -0.5 1.0 0.4 0.5 1.2 -1.5 1.7 0.9 1.3 -1.8
Handedness (chirality/laterality): Left-handed 0.9 1.0 4.2 -0.3 -0.3 0.4 -0.1 -0.3 1.3 -0.1 0.6 -0.2 2.1 1.8 0.4 2.0 0.8 -0.3 -1.3 0.8 1.5 -0.3
Mood swings 0.4 0.7 3.0 0.2 0.4 0.3 0.5 0.3 -0.8 1.1 -1.7 -0.0 -1.0 -1.4 -0.1 -1.5 0.4 0.3 0.3 -1.0 -0.5 -0.0
Loneliness, isolation 0.9 1.2 2.9 1.0 1.0 1.4 1.0 0.6 -0.2 1.2 -1.0 1.1 -0.0 -1.3 -1.4 -1.7 1.6 0.9 -0.4 -0.2 -1.7 1.3
Long-standing illness, disability or infirmity 0.8 1.2 6.9 -0.4 -0.3 0.3 0.7 -0.1 -0.7 0.6 1.6 0.1 -1.4 -2.6 0.9 -0.4 1.4 -0.3 -0.6 0.5 -2.6 0.4
Ever had bowel cancer screening 1.6 1.8 5.4 1.5 1.6 0.9 1.3 1.7 2.3 1.8 0.2 1.2 2.0 1.2 0.9 0.1 -1.2 1.5 -1.1 -0.7 1.4 1.0
Diabetes diagnosed by doctor 0.2 0.4 3.5 -0.6 -0.2 0.6 -0.2 -0.3 -1.1 0.1 -0.4 -0.1 -0.5 -1.9 -0.5 -0.2 0.2 -0.2 -0.5 -0.2 -0.9 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 5.5 0.4 0.2 0.4 0.0 -0.2 -1.6 -0.2 1.4 0.6 -1.4 -1.2 -2.4 -0.5 -0.4 0.3 1.1 -1.1 -2.1 0.7
Friendships satisfaction 0.4 0.5 1.4 0.7 0.9 0.5 0.6 0.8 0.1 1.0 -1.2 0.3 -0.4 -0.1 -0.0 -1.0 -0.9 0.8 -0.4 -1.1 -0.4 0.3
Qualifications: nursing, teaching 0.3 0.5 3.0 -0.3 -0.3 0.7 0.4 0.2 -0.2 -0.3 1.2 -0.2 -0.2 -1.7 1.5 -0.4 0.3 -0.2 -0.4 -0.0 -0.8 0.1
Commuting to job workplace: Walk 0.3 0.3 1.0 0.6 0.5 0.2 0.6 0.8 -0.5 0.4 1.0 0.5 0.5 0.1 0.9 0.1 -0.4 0.5 -0.4 0.1 0.5 0.6
Eye problems/disorders: Cataract 0.7 0.8 3.5 -1.1 -0.9 -0.8 -0.6 -0.6 -0.5 -1.1 0.2 -0.9 -1.3 0.7 1.9 -0.4 -0.6 -1.0 1.1 -0.2 0.0 -1.4
Mouth/teeth dental problems: Mouth ulcers 6.0 9.6 14.9 3.7 3.8 3.6 3.0 3.0 2.1 3.8 -1.5 3.9 2.4 -2.6 -3.3 -0.8 -2.9 3.7 -3.6 -3.8 -0.6 3.5
Medication for cholesterol 1.0 1.6 6.4 -0.5 -0.9 -0.5 -0.2 -0.5 0.7 -1.4 1.2 -0.7 0.7 1.6 2.0 2.1 1.7 -0.9 1.0 2.5 0.9 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 3.0 0.9 0.5 0.0 0.7 0.6 1.0 1.1 1.1 1.1 0.6 0.6 0.2 1.4 1.7 0.4 -1.4 1.3 -1.3 0.9
Back pain experienced in last month 0.3 0.5 1.6 0.6 0.8 0.6 1.1 0.9 -0.3 0.5 -1.2 0.3 -0.3 -1.3 0.9 -0.4 -0.0 0.7 0.2 -0.1 -0.4 0.3
Mineral and other dietary supplements 0.8 1.1 2.8 1.4 1.2 1.0 0.9 0.8 1.1 1.6 0.3 1.6 0.7 -0.1 -1.4 0.7 0.3 1.1 -1.1 -1.0 -0.3 1.7
Breast cancer (self-reported) 1.1 1.3 3.4 0.8 0.7 0.9 1.5 1.1 1.8 1.1 1.3 1.2 0.9 -0.2 1.8 -0.6 -1.9 0.7 -0.5 -1.0 -1.0 0.9
Asthma (self-reported) 9.7 19.3 134.6 0.2 -2.8 -0.9 0.0 -2.1 -0.2 -1.7 11.6 1.8 0.7 -0.2 1.1 7.3 5.0 -2.8 -1.5 8.3 -6.9 2.5
Osteoporosis (self-reported) 0.9 1.2 10.0 -1.1 -0.9 -0.3 -0.7 -1.1 -0.4 -1.3 -0.1 -0.6 -1.2 -0.3 -0.5 0.8 3.2 -0.9 1.3 0.2 -0.8 -0.7
Osteoarthritis (self-reported) 0.7 1.0 7.1 0.1 0.4 0.4 -0.1 0.3 0.5 -0.4 -1.2 -0.1 0.3 -0.5 -0.3 -2.0 -2.7 0.4 -0.2 -1.6 1.2 -0.5
Medication: Aspirin 0.9 1.1 4.0 1.1 1.0 1.3 0.5 0.6 0.4 1.1 -0.4 1.3 0.1 -1.3 -2.0 -0.6 -1.0 1.1 -1.0 -1.7 -0.6 0.9
Medication: Gliclazide 0.7 0.8 3.3 0.9 0.8 1.1 1.1 0.9 0.9 1.3 0.3 0.7 1.0 -0.1 0.1 1.2 1.8 0.8 -0.3 0.9 -0.1 0.7
Illnesses of father: None of the above (group 1) 0.7 0.9 3.2 -0.5 -0.8 0.3 0.0 -0.5 1.3 -0.9 1.8 -0.7 1.4 1.1 1.5 1.1 0.5 -0.8 -0.3 1.1 0.8 -0.5
Smoking status: Current 0.5 0.8 3.0 -0.3 -0.6 -0.5 -0.4 -1.0 -0.6 -0.4 0.9 -0.7 0.1 0.2 -1.4 1.7 1.0 -0.6 1.2 1.4 0.7 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 14.7 1.1 1.3 0.5 0.9 1.3 0.3 2.2 -3.8 0.7 -0.6 0.4 -0.2 -2.0 0.3 1.3 0.5 -1.4 -0.4 0.1
Whole body water mass 0.3 1.8 9.7 -0.4 -0.8 -1.2 -0.7 -0.7 -2.7 0.2 -1.3 -0.7 -2.7 1.4 0.5 -0.7 0.2 -0.8 3.1 -0.3 -0.4 -1.0
Leg predicted mass (right) 0.2 1.1 6.8 0.1 -0.0 -0.4 0.2 0.2 -1.6 0.9 -2.0 -0.3 -1.6 1.4 1.2 -0.7 0.5 -0.1 2.6 -0.3 0.2 -0.5
Arm fat mass (left) 0.2 0.7 2.7 1.2 0.8 0.5 0.8 0.9 0.1 1.6 -0.9 1.1 0.4 1.0 0.6 -0.3 -0.7 0.8 -0.3 -0.2 0.2 1.2
Number of self-reported non-cancer illnesses 1.2 2.0 13.5 0.5 -0.2 0.4 0.7 -0.1 -0.1 0.7 2.8 1.1 -0.7 -2.4 -0.2 1.4 1.1 -0.1 -1.6 1.1 -3.7 1.3
Average weekly champagne plus white wine intake 1.2 1.6 4.3 -1.4 -1.6 -1.4 -0.7 -1.3 -1.3 -2.1 1.8 -1.1 -1.1 0.8 1.2 0.5 -0.1 -1.6 1.8 0.5 -0.2 -1.5
Miserableness 1.1 1.9 11.1 -0.3 0.4 1.0 0.6 0.1 -1.0 0.6 -1.7 -0.3 -1.6 -3.3 -1.0 -2.8 0.8 0.5 0.6 -1.9 -1.6 0.1
Guilty feelings 1.9 2.8 10.9 1.3 1.8 1.6 1.1 1.1 0.4 1.6 -0.9 1.6 -0.2 -3.3 -3.0 -1.8 -0.3 1.7 -0.7 -2.4 -1.7 1.4
Wears glasses or contact lenses 1.5 1.8 6.2 -1.8 -1.3 -1.3 -1.3 -1.4 -0.6 -0.7 -2.5 -1.9 -1.1 -0.4 0.3 -1.0 -0.7 -1.3 -0.6 -0.7 1.3 -2.2
Ever taken oral contraceptive pill 0.5 0.6 5.2 0.6 0.4 0.8 0.7 0.3 -0.7 0.6 0.2 0.3 -0.1 0.0 -0.7 0.0 2.3 0.5 0.4 0.4 -1.0 0.8
Hearing aid user 2.0 2.3 7.1 -1.9 -1.5 -0.8 -1.3 -1.3 -1.2 -1.6 -1.8 -1.6 -2.7 -2.0 0.6 -1.3 0.8 -1.5 1.2 -0.4 -1.6 -1.7
Mother’s age at death 3.4 4.3 13.2 -2.0 -2.0 -2.0 -1.9 -1.8 0.1 -2.4 0.1 -2.3 1.0 3.6 1.7 1.8 1.0 -2.0 1.2 2.7 3.3 -2.5
Financial situation satisfaction 1.5 1.8 4.4 1.9 1.6 2.1 2.0 1.5 0.9 1.4 1.0 1.8 1.2 -0.5 -0.5 -0.4 0.1 1.7 -0.6 -0.3 -1.2 1.9
Tinnitus: Yes, now most or all of the time 1.0 1.2 7.6 -0.6 -0.3 -0.5 -1.1 -1.0 -1.1 -0.3 -0.7 -0.6 -1.8 -1.6 -2.8 -0.8 0.3 -0.4 0.1 -1.4 -0.9 -0.7
Commuting to job workplace: Public transport 0.6 0.8 4.4 -0.7 -0.8 -0.5 -0.5 -0.4 0.1 -0.4 -0.5 -0.8 -0.4 -0.0 2.0 -0.2 0.8 -0.8 -2.1 0.6 0.2 -1.1
Eye problems/disorders: Glaucoma 0.9 1.1 5.7 -0.4 -0.4 0.2 0.4 0.2 0.3 0.3 0.4 0.2 0.0 -2.0 2.4 -1.4 -1.4 -0.3 -2.2 -0.3 -1.0 0.4
Medication: Blood pressure 0.3 0.6 3.4 -0.8 -0.2 -0.0 -0.5 -0.4 -0.6 -0.1 -1.8 -0.5 -0.8 -0.9 -0.4 -1.6 -0.6 -0.2 -0.8 -1.2 -0.5 -0.2
Pain type(s) experienced in last month: Hip pain 3.4 4.3 9.5 -2.6 -2.8 -3.1 -2.2 -2.5 -2.5 -1.7 0.2 -2.4 -2.0 0.7 1.8 1.5 -0.3 -2.8 0.6 2.5 0.5 -2.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.5 -1.0 -0.9 -0.3 -0.4 -0.6 -1.2 -1.2 0.4 -1.0 -1.3 -1.7 1.0 -1.9 -0.5 -0.8 0.6 -0.1 -1.5 -0.8
High cholesterol (Self-reported) 0.9 1.5 4.0 1.5 1.3 1.2 0.9 0.9 0.6 1.9 0.3 1.6 0.9 -0.2 -2.0 -0.4 -1.0 1.3 -1.9 -1.2 -0.2 1.5
Medication: Bendroflumethiazide 0.9 1.3 5.0 0.6 0.4 -0.4 0.1 0.4 1.4 0.4 -1.8 0.7 2.0 2.2 -0.3 0.6 -1.2 0.4 -1.6 0.6 2.1 0.5
Medication: Paracetamol 1.3 2.0 6.9 0.7 1.1 0.7 1.0 1.1 -1.0 1.7 -0.8 1.3 -1.6 -2.6 0.1 -2.1 -0.6 1.1 -1.3 -1.8 -2.3 1.2
Medication: Lisinopril 0.3 0.4 1.8 -0.2 -0.2 -0.0 -0.2 -0.1 -1.1 -1.0 -0.0 0.2 -0.8 -0.9 0.0 0.0 -0.6 -0.2 -0.7 -0.3 -1.3 0.3
Medication: Atorvastatin 1.0 1.3 3.5 -1.0 -1.3 -1.4 -1.9 -1.6 -1.9 -0.1 0.2 -0.9 -1.3 -0.3 -1.7 -0.2 0.8 -1.3 0.4 1.0 0.0 -1.1
Illnesses of father: High blood pressure 2.0 2.5 10.8 0.7 1.4 1.8 1.0 1.1 0.6 1.7 -1.4 0.6 -0.8 -2.7 -1.6 -3.3 1.0 1.5 -0.3 -2.2 -2.0 1.2
Alcohol drinker status: Never 2.6 3.1 13.7 1.8 1.8 1.7 1.8 1.8 1.4 2.4 0.1 2.0 1.3 -1.3 -0.5 -0.8 -1.6 1.9 -3.7 -1.3 -0.7 2.0
Ever smoked 0.8 1.4 6.3 -0.5 -0.8 -1.1 -1.2 -1.3 -1.3 -1.5 1.0 -0.7 -0.8 1.4 -1.6 1.4 -0.2 -0.9 2.5 0.4 0.7 -1.2
Basal metabolic rate 0.2 1.4 7.2 -0.1 -0.5 -0.9 -0.4 -0.4 -2.4 0.5 -1.3 -0.4 -2.4 1.3 0.5 -0.8 0.1 -0.5 2.7 -0.4 -0.4 -0.7
Leg fat percentage (left) 0.3 1.2 4.3 1.5 1.1 0.5 1.0 1.1 0.9 1.8 0.1 1.8 0.6 0.4 0.2 -0.2 -1.2 1.0 -2.1 -0.6 -0.3 1.8
Arm fat-free mass (left) 0.2 1.2 6.9 0.1 -0.3 -0.8 -0.3 -0.3 -2.3 0.6 -1.1 -0.0 -2.6 0.8 0.0 -0.8 -0.2 -0.4 2.1 -0.6 -1.2 -0.2
Number of operations (self-reported) 1.5 2.3 6.1 1.8 1.6 1.1 1.9 1.5 1.3 1.8 1.0 2.1 0.8 -0.9 -0.6 -0.8 -2.5 1.6 -1.5 -1.3 -1.1 1.8
Average weekly beer plus cider intake 1.2 1.8 4.6 1.8 1.7 1.8 2.1 1.8 0.5 1.5 -0.2 1.7 1.0 -0.8 0.4 -0.9 0.2 1.7 -0.5 -1.3 -0.4 1.7
Irritability 0.6 1.0 2.9 -1.2 -0.7 -1.1 -1.3 -0.6 -1.0 -0.1 -1.7 -1.0 -1.3 -1.1 0.7 -1.4 -1.1 -0.8 -0.4 -0.9 0.6 -1.2
Risk taking 1.5 2.2 7.1 1.6 1.6 1.9 1.6 1.4 0.3 1.1 -1.1 1.4 -0.0 -2.7 -1.1 -2.2 0.3 1.6 -0.0 -1.2 -2.2 1.4
Ever had prostate specific antigen (PSA) test 2.1 2.4 4.8 -1.7 -1.6 -2.1 -1.7 -1.9 -0.8 -1.6 0.4 -1.8 -1.4 2.2 -0.7 1.7 0.6 -1.7 2.0 0.8 1.0 -2.0
Fractured/broken bones in last 5 years 1.3 1.7 4.0 1.6 1.5 1.8 1.9 1.6 2.0 1.5 -0.3 1.3 1.8 -0.2 0.3 0.7 1.2 1.6 0.7 0.1 0.2 1.4
Age started oral contraceptive pill 0.4 0.5 2.3 -0.1 0.6 1.0 0.4 0.5 0.7 0.0 -1.0 -0.1 -0.2 -1.1 -0.5 -1.2 0.5 0.6 1.5 -0.8 -0.7 -0.1
Diastolic blood pressure, automated reading 1.1 3.4 10.7 2.2 2.3 1.7 1.6 1.8 0.6 2.6 -0.8 2.2 0.3 -1.2 -1.6 -2.3 -1.9 2.2 -0.8 -3.3 -0.8 2.0
Ever depressed for a whole week 0.5 0.6 2.0 -0.5 -0.9 -0.7 -0.6 -0.7 0.5 -0.9 1.0 -0.3 0.8 0.1 1.1 0.5 -0.7 -0.9 -1.4 1.0 0.8 -0.5
Unable to work because of sickness or disability 1.7 2.2 4.8 1.9 2.0 2.2 2.0 1.9 1.4 1.6 -0.1 2.1 1.4 -0.9 -0.6 0.7 0.6 2.0 -0.3 -0.2 -0.8 2.2
Commuting to job workplace: Cycle 0.4 0.5 1.9 -0.6 -0.3 -0.0 -0.1 0.1 -0.2 -1.1 -1.2 -0.5 -0.4 -0.2 1.4 0.6 1.3 -0.3 0.2 0.9 -0.1 -0.4
Myopia 0.8 1.1 3.9 -0.6 -1.2 -1.4 -0.9 -1.2 -0.4 -0.5 1.9 -0.4 0.2 1.3 -0.2 2.0 0.7 -1.2 -0.8 1.0 1.2 -0.6
Vascular/heart problems diagnosed by doctor 0.6 1.5 5.0 1.1 0.5 0.6 1.4 0.9 1.0 -0.1 2.2 0.9 1.5 2.2 1.6 1.8 0.9 0.5 1.0 1.3 0.5 0.7
Cholesterol lowering medication 1.0 1.5 5.8 1.3 1.3 0.8 0.9 1.1 1.3 1.6 -0.5 1.6 0.9 -0.3 -1.1 -0.2 -1.6 1.3 -2.4 -1.3 0.1 1.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 5.0 0.3 0.9 0.5 0.6 0.6 1.0 1.4 -1.5 0.7 -0.2 -2.2 -0.6 -1.1 -0.7 0.8 -1.2 -1.5 -1.0 0.7
Pain experienced in last month 0.2 0.3 1.8 -0.3 -0.2 -0.2 -0.2 -0.4 -0.3 -0.1 0.3 -0.3 -0.5 0.2 -1.1 -0.4 1.3 -0.2 1.0 -0.7 -0.5 0.1
Supplements: Calcium 0.9 1.0 3.1 1.1 1.2 0.9 1.0 1.0 1.3 1.3 -0.2 0.9 1.8 1.3 -0.3 0.3 -0.7 1.1 0.4 0.0 1.1 0.8
Basal cell carcinoma (self-reported) 2.7 3.2 6.0 -2.3 -2.3 -2.4 -2.5 -2.2 -1.5 -2.1 0.1 -2.3 -1.5 0.6 0.7 0.3 -0.0 -2.3 2.2 0.7 1.4 -2.4
Heart attack/myocardial infarction (self-reported) 0.9 1.1 8.6 0.2 0.2 0.4 -0.4 -0.4 -0.8 0.0 -0.1 0.4 -1.1 -1.4 -2.9 -1.3 -1.4 0.3 0.1 -1.7 -0.9 0.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.9 -0.2 -0.0 -0.6 -0.8 -0.4 -1.0 0.2 -0.2 -0.0 -0.6 -0.2 -1.3 0.5 -1.7 -0.1 0.3 -0.9 0.4 -0.4
Heart disease (siblings) 0.3 0.4 2.0 -0.3 -0.3 -0.4 -0.7 -0.6 0.8 -0.3 0.2 -0.3 0.8 0.7 -1.4 -0.6 -0.9 -0.2 -0.0 0.2 0.8 -0.4
Alcohol drinker status: Previous 0.9 1.0 3.3 0.6 1.1 1.2 0.8 0.8 0.2 1.0 -0.4 1.0 0.3 -1.2 -1.8 -0.8 -0.9 1.1 -0.4 -1.5 -1.0 1.1
Pack years of smoking 0.4 0.5 2.1 0.7 0.7 0.2 -0.0 0.5 1.4 0.8 -1.0 0.9 0.8 -0.3 -0.6 -0.3 -0.4 0.7 -0.9 -0.7 1.2 0.5
Impedance of whole body 0.1 0.7 3.9 0.3 0.5 0.8 0.5 0.4 1.8 -1.0 1.4 0.1 2.0 -0.3 -0.6 0.2 0.6 0.5 -0.0 1.1 0.3 0.6
Leg fat mass (left) 0.2 0.6 2.5 1.1 0.6 0.3 0.8 0.8 0.2 1.6 -0.9 1.1 0.1 0.8 0.9 -0.4 -0.4 0.6 -0.8 -0.3 -0.1 1.1
Arm predicted mass (left) 0.2 1.2 7.1 0.0 -0.4 -0.8 -0.4 -0.4 -2.4 0.5 -0.8 -0.0 -2.7 0.7 -0.1 -0.8 0.1 -0.4 2.3 -0.6 -1.3 -0.3