TWAS hub - IL18RAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1410	0.0330	3.7e-12	0.175	NA	0.169	NA	0.175	5.8e-16	NA	2.3e-15	NA	6.0e-16
2	NTR	Blood	0.1418	0.0240	0.0e+00	0.163	0.173	0.190	0.191	0.192	3.0e-50	2.1e-53	4.5e-59	2.9e-59	1.1e-59
3	YFS	Blood	0.4133	0.0383	0.0e+00	0.554	0.606	0.619	0.622	0.617	1.7e-223	8.4e-258	6.8e-267	4.2e-269	4.2e-265
4	TCGA	Glioblastoma Multiforme	0.3440	0.1190	3.0e-03	0.019	0.084	0.084	NA	0.061	8.6e-02	1.5e-03	1.5e-03	NA	6.5e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0329	0.0184	2.0e-03	0.018	0.023	0.022	NA	0.014	3.6e-03	1.2e-03	1.4e-03	NA	8.0e-03
6	TCGA	Brain Lower Grade Glioma	0.0300	0.0174	5.3e-03	0.027	0.014	0.011	NA	0.014	4.4e-04	8.5e-03	1.7e-02	NA	7.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Eosinophil Count	51.1	393.2	1176.5	-5.3	-20.1	-21.2	-16.9	34.3	-3.9
Allergy or Eczema	29.2	76.8	249.6	-5.2	-8.1	-9.3	-4.7	15.8	-3.2
Allergy	28.2	64.9	243.4	2.5	6.8	7.8	5.7	-15.6	1.1
Asthma (self-reported)	24.5	48.8	179.6	-1.8	-6.5	-7.2	-3.9	13.4	-0.9
Asthma	23.9	47.2	174.2	-1.9	-6.4	-7.0	-3.8	13.2	-0.9
Hayfever, allergic rhinitis or eczema	21.7	47.1	169.0	-3.2	-6.0	-6.9	-4.2	13.0	-1.7
Respiratory disease	21.4	47.6	187.7	-0.8	-6.0	-6.8	-3.8	13.7	0.4
Medication: Ventolin 100micrograms inhaler	18.3	23.5	73.6	-2.1	-5.0	-5.2	-2.9	8.6	-1.8
Hayfever/allergic rhinitis (self-reported)	13.9	18.3	57.9	-0.9	-4.2	-4.4	-3.7	7.6	-0.7
Wheeze or whistling in the chest in last year	11.8	21.1	87.6	-0.2	-3.6	-4.1	-3.0	9.4	0.1
Crohns Disease (2012)	9.5	15.4	29.8	-5.5	-3.5	-3.6	2.7	0.9	-5.4
Crohns Disease (2017)	8.3	18.1	41.1	-6.4	-3.1	-3.2	3.5	-0.3	-6.0
Medication: Seretide 50 evohaler	6.1	7.0	21.4	-1.0	-2.9	-3.0	-0.9	4.6	-1.0
Irritable Bowel Disease (IBD)	5.5	13.2	30.8	-5.5	-2.0	-2.3	3.5	-0.4	-5.2
Townsend deprivation index at recruitment	4.3	6.1	11.8	-2.5	-2.0	-2.2	-1.9	3.4	-2.4
Hearing aid user	4.0	4.5	8.2	2.9	2.2	2.3	0.6	-1.0	2.7
Intelligence (Savage-Jansen 2018)	3.6	11.0	16.9	3.2	3.9	4.1	-2.2	-2.8	3.4
Severe depression (siblings)	3.6	4.1	18.1	-0.6	0.6	0.3	4.3	-2.3	0.2
Neuroticism (Nagel 2018)	3.4	8.1	12.7	2.3	2.9	3.0	2.5	-3.6	2.7
Qualifications: CSEs or equivalent	3.4	4.5	6.6	-1.1	-2.4	-2.2	-2.6	2.3	-1.7
Miserableness	3.3	5.7	8.4	1.7	2.9	2.8	1.9	-2.5	2.4
Depressed Affect (Nagel 2018)	3.2	6.6	8.9	1.5	2.9	2.8	2.6	-3.0	2.3
Illnesses of father: High blood pressure	3.0	3.7	5.9	1.1	2.4	2.4	1.7	-2.2	1.4
Alzheimer’s Disease (in father)	2.9	3.1	5.6	1.6	2.4	2.1	-1.6	-0.1	1.8
Alzheimer’s Disease (including proxy)	2.9	4.2	6.1	1.8	2.5	2.4	-2.5	-0.4	2.0
Ulcerative Colitis	2.8	4.0	10.3	-3.0	-1.1	-1.3	1.2	0.7	-3.2
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	7.3	2.7	1.4	1.6	-0.7	-0.6	2.6
Neuroticism (2016)	2.5	3.6	7.9	1.6	1.5	1.5	2.8	-1.7	1.9
Fluid intelligence score	2.5	5.2	7.0	2.3	2.4	2.6	-1.2	-2.6	2.1
Chest pain or discomfort	2.5	3.6	14.0	1.5	-0.4	-0.5	-1.4	3.7	1.6
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	4.0	-1.7	-1.7	-2.0	1.3	1.8	-1.6
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	4.8	-2.2	-1.6	-1.8	2.2	1.6	-2.1
Medication: Bendroflumethiazide	2.3	3.4	6.1	-2.1	-2.3	-2.0	-0.2	0.8	-2.5
Taking other prescription medications	2.2	3.4	16.1	1.5	-0.0	-0.4	-0.1	4.0	1.3
Medication: Atenolol	2.2	2.8	10.0	0.8	1.4	1.7	1.0	-3.2	0.3
Tinnitus: Yes, now most or all of the time	2.2	2.6	4.4	2.1	1.5	1.8	0.9	-1.1	2.0
Supplements: Fish oil (including cod liver oil)	2.2	2.9	4.4	1.6	1.7	1.6	2.1	-1.5	1.8
Myopia	2.2	3.2	6.2	-0.4	-2.2	-2.0	-1.9	2.5	-0.9
Verbal and Numeric Reasoning (VNR)	2.1	5.1	7.3	2.3	2.3	2.6	-0.9	-2.7	2.3
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.8	-2.2	-1.4	-1.6	0.1	1.5	-1.8
Neuroticism	2.0	4.7	7.7	1.2	2.8	2.6	1.6	-2.5	1.8
Fed-up feelings	2.0	3.7	7.1	1.6	2.7	2.6	0.3	-1.2	2.1
Noisy workplace	2.0	2.5	6.7	-1.1	-1.6	-1.7	-0.1	2.6	-1.3
Medication: Co-codamol	1.9	2.2	3.8	2.0	1.3	1.4	-0.1	-1.7	1.7
Had other major operations	1.9	2.3	6.2	-1.1	-1.6	-1.8	0.3	2.5	-0.6
Emphysema/chronic bronchitis	1.9	2.1	5.2	1.0	0.3	0.1	-2.2	2.3	1.3
Number of full sisters	1.9	2.3	5.0	1.0	1.7	1.7	1.1	-2.2	1.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.2	-1.8	-1.4	-1.4	-1.0	1.6	-1.8
Medication: Lansoprazole	1.8	2.0	3.7	-1.3	-1.5	-1.4	-0.9	1.4	-1.9
Loud music exposure frequency	1.8	1.9	3.2	-1.2	-1.8	-1.7	-0.3	1.8	-0.9
Worry too long after embarrassment	1.8	3.1	5.1	1.5	2.3	2.3	-0.6	-1.5	1.8
Number of self-reported non-cancer illnesses	1.8	3.1	15.2	0.7	-0.9	-1.3	0.0	3.9	0.4
Bipolar Disorder (2011)	1.7	1.6	2.6	-0.9	-1.2	-1.2	-1.6	1.4	-1.3
Fasting Glucose	1.7	2.1	3.6	1.0	1.9	1.7	-1.9	-0.4	1.2
Lung FEV1/FVC ratio	1.7	8.5	19.5	-4.0	-0.7	-0.5	-0.3	-3.8	-4.4
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.0	-1.7	-1.2	-1.4	-0.7	1.6	-1.6
High blood pressure (mother)	1.7	2.4	4.4	-0.9	-1.9	-1.8	-0.8	2.1	-1.5
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	6.1	-0.4	-1.1	-1.3	-1.7	2.5	-0.3
Pulse wave reflection index	1.7	2.1	4.6	-2.1	-1.3	-1.4	0.6	0.6	-1.8
Alzheimer’s Disease (in mother)	1.6	1.8	2.9	1.5	1.2	1.2	-1.7	-0.1	1.7
Ulcerative Colitis (UC)	1.6	2.9	6.1	-2.5	-0.5	-0.7	2.3	-0.3	-2.3
Lupus	1.6	2.4	7.6	-0.9	0.6	0.5	2.8	-2.2	-0.6
Vitamin and mineral supplements	1.6	2.2	6.0	-1.1	-1.1	-1.0	-2.4	1.3	-1.5
Serious illness, injury or assault to yourself	1.6	1.9	3.0	-1.6	-1.4	-1.4	1.7	0.6	-1.2
Birth weight	1.6	3.5	5.9	1.7	2.2	2.4	-1.8	-1.4	1.6
Number of operations (self-reported)	1.6	2.3	6.5	-1.0	-1.6	-1.6	2.5	0.7	-1.0
Age started oral contraceptive pill	1.6	2.0	4.2	0.4	2.0	2.0	0.5	-1.6	0.9
Neuroticism score	1.5	3.2	4.9	1.2	2.2	2.2	1.2	-1.9	1.7
Time employed in main current job	1.5	1.7	2.8	-1.4	-1.7	-1.7	0.9	0.5	-1.3
Alcohol intake versus 10 years previously	1.5	2.2	3.8	1.0	1.6	1.6	1.4	-2.0	1.2
Forced vital capacity (FVC), Best measure	1.5	5.5	9.2	1.9	2.6	2.5	0.1	-3.0	2.8
Medication: Ibuprofen	1.5	1.8	2.6	1.6	1.6	1.6	0.6	-0.9	1.4
Ever depressed for a whole week	1.5	1.8	4.0	-1.1	-1.4	-1.5	-0.9	2.0	-0.9
Bipolar Disorder (2018)	1.4	2.2	6.6	-0.5	-0.8	-1.1	-2.6	1.9	-0.8
Mean Putamen Volume	1.4	1.6	2.5	-1.1	-1.5	-1.6	0.4	1.6	-1.1
Height	1.4	27.9	40.7	5.1	5.6	5.8	-2.1	-6.4	5.6
Hand grip strength (right)	1.4	3.7	8.2	1.8	1.3	1.3	1.8	-2.9	2.1
Forced vital capacity (FVC)	1.4	5.3	9.2	2.0	2.3	2.3	0.1	-3.0	2.9
Supplements: Vitamin C	1.4	1.6	7.9	-0.8	-0.6	-0.7	2.8	-0.1	-0.5
Ever had prostate specific antigen (PSA) test	1.4	1.6	5.6	1.4	0.6	0.9	-2.4	-0.3	0.8
Supplements: Calcium	1.4	1.5	3.2	-1.8	-0.9	-0.9	1.1	-0.6	-1.6
Number of treatments/medications taken	1.3	2.4	11.8	1.2	-0.1	-0.2	-0.8	3.4	0.6
Supplements: Zinc	1.3	1.4	2.1	-1.1	-1.4	-1.3	0.0	1.5	-1.2
Relative age voice broke	1.3	2.0	3.7	-0.1	1.6	1.4	1.9	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	12.2	0.7	2.1	2.2	0.2	-3.5	1.4
Age at last live birth	1.3	1.8	7.0	0.5	1.4	1.3	-2.6	0.1	0.5
Ever had bowel cancer screening	1.3	1.5	4.3	-1.5	-1.2	-1.0	0.1	-0.2	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.5	-0.6	-1.2	-1.3	-0.9	2.1	-0.5
Alcohol drinker status: Never	1.3	1.5	2.5	-1.2	-1.2	-1.4	0.5	1.6	-1.3
Multivitamins +/- minerals	1.2	1.5	2.8	1.2	0.9	0.8	1.7	-0.8	1.6
Sitting height	1.2	8.4	12.8	2.5	3.2	3.1	-0.8	-3.6	3.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.2	1.4	1.0	1.0	1.3	-0.9	1.5
Prospective memory result	1.2	1.5	2.9	-1.7	-1.2	-1.3	0.3	0.7	-1.6
Illnesses of siblings: Diabetes	1.2	1.5	2.5	1.0	1.6	1.5	-1.2	-1.2	0.6
Mood swings	1.2	2.2	3.8	1.0	1.5	1.5	1.6	-1.9	1.2
Mineral and other dietary supplements	1.2	1.6	3.6	-0.8	-1.3	-1.2	-1.1	1.9	-0.9
Mother’s age at death	1.2	1.5	6.0	-0.9	-0.6	-0.3	-2.5	-0.2	-1.3
Depression (Nagel 2018)	1.1	1.6	3.0	0.4	1.5	1.6	1.3	-1.7	0.6
Schizophrenia (2018)	1.1	2.3	6.2	1.4	1.5	1.6	0.4	-2.5	1.0
Hearing difficulty/problems: Yes	1.1	1.8	3.0	1.7	1.2	1.5	0.8	-0.7	1.7
Average weekly fortified wine intake	1.1	1.3	6.1	-0.3	0.3	0.4	2.5	-1.1	-0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.3	-1.3	-0.9	-1.0	-0.2	1.1	-1.5
Number of incorrect matches in round	1.1	1.8	3.5	-1.0	-1.9	-1.8	0.3	0.7	-1.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	12.9	0.8	1.8	1.9	0.5	-3.6	1.4
Qualifications: College or University degree	1.1	3.3	5.1	1.7	2.0	2.2	0.3	-2.3	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.6	-0.6	-1.0	-1.1	2.1	0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	4.9	0.9	0.3	0.5	1.3	-2.2	0.7
Unable to work because of sickness or disability	1.1	1.5	2.6	-1.5	-1.0	-1.2	0.0	1.6	-1.2
Cardiovascular Disease	1.0	3.2	7.2	2.7	1.7	1.9	1.0	-1.1	1.9
Lung FVC	1.0	5.3	7.5	1.9	2.6	2.7	0.7	-2.7	2.5
Diabetes (father)	1.0	1.3	4.7	-0.0	-0.9	-0.5	2.2	-1.3	-0.3
Diabetes (mother)	1.0	1.3	4.0	-1.3	-0.5	-0.6	-0.7	2.0	-1.0
Arm fat percentage (right)	1.0	3.9	6.2	-1.6	-2.2	-2.1	-1.4	1.9	-2.5
Medication for cholesterol	1.0	1.5	3.3	-0.9	-0.9	-1.0	-1.8	1.8	-0.4
Breast cancer (self-reported)	1.0	1.2	3.1	-1.0	-1.0	-1.1	1.7	0.8	-0.6
Osteoporosis (self-reported)	1.0	1.2	2.6	1.0	0.5	0.5	-1.6	1.3	1.2
Illnesses of father: None of the above (group 1)	1.0	1.3	2.3	-1.2	-0.9	-1.1	-1.0	1.5	-1.0
Fractured/broken bones in last 5 years	1.0	1.3	3.6	-1.9	-0.6	-0.9	0.0	1.1	-1.4
Cholesterol lowering medication	1.0	1.4	2.9	-0.9	-1.2	-1.1	1.7	-0.0	-1.4
Ever had hysterectomy (womb removed)	0.9	1.0	2.4	1.6	0.6	0.7	0.9	-0.0	1.4
Pack years adult smoking proportion	0.9	1.4	2.1	-1.4	-1.2	-1.1	-0.8	1.1	-1.5
Trunk fat-free mass	0.9	4.9	10.0	3.0	1.4	1.3	0.3	-2.5	3.2
Hair/balding pattern: Pattern 3	0.9	1.3	4.9	-0.5	-0.4	-0.1	-2.2	1.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.7	1.1	1.9	1.8	-0.7	-1.3	1.1
Trunk predicted mass	0.9	5.1	10.4	3.1	1.5	1.4	0.2	-2.6	3.2
Standing height	0.9	9.0	17.6	2.9	2.8	2.8	-0.3	-4.2	3.5
Birth weight of first child	0.9	1.7	2.6	1.0	1.4	1.4	-1.6	-0.9	1.3
Body fat percentage	0.9	3.4	5.2	-1.4	-2.1	-2.1	-1.1	1.9	-2.3
Leg fat percentage (right)	0.9	3.4	5.9	-0.8	-2.4	-2.4	-0.7	2.2	-1.7
Number of full brothers	0.9	1.2	2.9	1.4	0.6	0.6	1.2	-0.1	1.7
Health satisfaction	0.9	1.2	2.6	1.6	-0.2	-0.1	1.4	-0.2	1.6
Shortness of breath walking on level ground	0.9	1.1	4.3	0.8	-0.8	-0.7	2.1	0.3	0.5
Medication for pain relief, constipation, heartburn	0.9	1.5	2.8	-1.7	-1.1	-1.1	-1.3	-0.1	-1.4
Medication: Omeprazole	0.9	1.0	1.9	1.0	1.4	1.2	0.2	0.5	1.1
Suffer from ‘nerves’	0.9	1.4	5.5	0.6	0.9	0.9	0.5	-2.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.8	-0.7	-0.7	-0.9	-0.9	1.7	-0.9
Smoking status: Previous	0.9	1.3	4.5	-0.1	-1.0	-1.0	-2.1	1.0	-0.5
Arm fat percentage (left)	0.9	3.5	6.2	-1.6	-2.1	-2.0	-1.2	1.5	-2.5
Wears glasses or contact lenses	0.9	1.0	1.8	1.2	1.2	1.3	-0.3	-0.8	0.8
Irritability	0.9	1.5	3.0	1.4	1.0	1.2	1.0	-1.7	0.8
Pack years of smoking	0.9	1.3	1.7	-1.2	-1.0	-1.0	-1.1	1.2	-1.3
Prostate Cancer	0.8	1.1	2.3	-1.2	-0.3	-0.4	1.5	-1.0	-1.3
Hearing difficulty/problems with background noise	0.8	1.3	2.6	1.6	0.9	1.2	0.3	-1.0	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.6	1.3	1.0	1.1	-0.6	-0.4	1.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.5	-1.2	-0.2	-0.5	1.9	0.5	-0.5
Headache pain in last month	0.8	1.4	4.2	-0.1	0.1	-0.1	-2.0	2.0	-0.3
Glaucoma (self-reported)	0.8	1.0	3.2	-0.7	-0.8	-1.0	0.1	1.8	-0.7
Arm fat-free mass (right)	0.8	4.1	8.5	2.9	1.2	1.1	0.4	-2.2	2.9
Long-standing illness, disability or infirmity	0.8	1.2	2.9	1.3	0.7	0.5	-0.2	1.7	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.8	1.0	0.8	0.7	0.2	0.3	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.1	0.8	1.7	1.8	-0.3	-1.5	0.9
Guilty feelings	0.8	1.1	3.9	0.4	0.9	0.9	2.0	-0.7	0.8
Financial situation satisfaction	0.8	0.9	2.0	-1.3	-0.4	-0.7	1.4	0.8	-0.7
High cholesterol (Self-reported)	0.8	1.3	2.5	-0.9	-1.3	-1.3	0.4	1.1	-1.6
HbA1C	0.7	0.8	2.6	1.2	0.7	0.3	-0.3	-0.3	1.6
Breastfed as a baby	0.7	0.8	2.2	-0.5	0.7	0.6	1.3	-1.5	0.0
Tense / ‘highly strung’	0.7	1.2	2.3	-0.6	-1.5	-1.4	1.5	-0.1	-0.5
Gout (self-reported)	0.7	1.0	4.1	-0.2	0.4	0.5	1.0	-2.0	-0.5
Pulse wave peak to peak time	0.7	0.9	1.8	0.5	1.3	1.2	-0.0	-1.0	0.9
Arm predicted mass (right)	0.7	3.5	7.2	2.6	1.2	1.1	0.5	-2.1	2.7
Whole body fat-free mass	0.7	3.7	6.9	2.5	1.3	1.2	0.2	-2.4	2.6
Friendships satisfaction	0.7	0.9	2.0	0.5	0.8	0.6	1.2	-1.4	0.8
Eye problems/disorders: Cataract	0.7	0.8	1.6	1.3	0.8	0.7	-0.6	-0.8	1.1
Osteoarthritis (self-reported)	0.7	0.9	2.6	-0.2	0.4	0.4	1.6	-1.6	-0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.9	1.7	0.0	-0.0	-1.1	0.4	1.1
Medication: Paracetamol	0.7	1.0	2.2	1.5	0.9	1.0	-0.1	0.5	1.4
Leg fat percentage (left)	0.7	2.7	4.5	-0.7	-2.1	-2.1	-0.8	2.0	-1.5
Risk taking	0.7	1.0	2.3	0.5	1.4	1.1	1.5	0.0	0.8
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.5	-1.8	-1.7	-1.9	0.1	0.8	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	-0.9	-0.8	-0.6	0.8	-0.1	-1.4
Tanning	0.6	6.8	15.8	4.0	1.8	2.0	-1.1	-0.7	4.0
Sensitivity / hurt feelings	0.6	1.0	1.9	1.2	1.1	1.2	-0.2	-0.3	1.4
Angina	0.6	0.8	1.4	0.8	1.2	1.2	0.6	0.2	0.9
Trunk fat percentage	0.6	2.6	5.3	-1.5	-1.6	-1.5	-1.2	1.2	-2.3
Supplements: Glucosamine	0.6	0.8	1.4	1.2	0.7	0.7	0.7	-1.0	1.0
Illnesses of siblings	0.6	0.8	1.2	-0.8	-1.1	-1.1	-0.3	1.1	-0.6
Number of live births	0.6	0.8	1.9	0.7	0.8	0.9	0.3	-1.4	0.9
Lung cancer (father)	0.6	0.7	2.1	1.2	-0.1	-0.0	0.9	-0.1	1.4
Illnesses of mother	0.6	0.7	1.4	0.5	0.7	0.6	0.8	-1.2	1.0
Exposure to tobacco smoke at home	0.6	0.7	1.8	1.0	-0.4	-0.1	-1.4	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.3	-0.1	-0.0	-0.1	1.8	-1.0	0.0
Number of children fathered	0.6	0.7	1.1	-0.9	-1.0	-1.1	0.6	-0.2	-0.9
Age at first live birth	0.6	1.0	3.5	0.7	0.9	0.9	-1.9	0.1	0.7
Neck or shoulder pain in last month	0.6	0.9	2.9	-0.3	-0.7	-0.8	-1.1	1.7	-0.4
Migraine (self-reported)	0.6	0.7	1.9	0.5	1.4	1.3	0.0	-0.1	0.6
Medication: Allopurinol	0.6	0.8	1.7	0.3	1.3	1.3	0.4	-1.1	0.2
Medication: Blood pressure	0.6	1.1	2.2	0.9	1.1	1.1	0.9	-1.5	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	1.3	0.2	0.4	-0.4	-1.1	1.1
Major Depression (MDD)	0.5	0.5	1.0	0.6	1.0	0.9	0.9	-0.2	0.5
HDL Cholesterol	0.5	0.9	2.2	-0.3	-1.5	-1.3	0.5	1.0	-0.4
Primary Biliary Cirrhosis	0.5	0.8	2.6	-0.0	0.9	0.9	-1.6	0.5	-0.6
Relative age of first facial hair	0.5	1.0	2.2	-1.0	-0.8	-0.7	1.5	-0.5	-1.2
Age when periods started (menarche)	0.5	1.1	2.8	0.1	1.7	1.5	0.6	-0.9	0.8
Stomach or abdominal pain in last month	0.5	0.6	2.8	0.3	-0.5	-0.6	-0.5	1.7	0.3
Medication: Levothyroxine sodium	0.5	0.8	2.2	0.8	0.5	0.6	0.7	-1.5	0.8
Nervous feelings	0.5	1.0	3.7	0.5	0.8	1.0	0.0	-1.9	0.5
Falls in the last year	0.5	0.6	3.5	-0.3	-0.1	-0.3	0.0	1.9	-0.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.4	-1.2	-1.0	-0.0	0.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.7	0.8	0.9	-1.3	-0.1	0.7
Peak expiratory flow (PEF)	0.5	1.2	3.8	0.1	0.8	0.7	1.4	-1.9	0.7
Eye problems/disorders: None of the above	0.5	0.5	1.7	-1.3	-0.4	-0.4	0.4	-0.4	-0.9
Hypertension (Self-reported)	0.5	1.4	3.4	1.8	1.2	1.4	-0.0	-0.7	0.9
Commuting to job workplace: Walk	0.5	0.5	1.0	-0.7	-0.7	-0.7	1.0	-0.5	-0.7
Back pain experienced in last month	0.5	0.7	1.2	0.2	1.1	0.9	1.1	-0.8	0.5
Whole body water mass	0.5	3.1	6.0	2.4	1.1	1.1	0.1	-2.2	2.4
Ever taken oral contraceptive pill	0.5	0.6	1.8	0.1	0.5	0.5	-1.4	1.0	0.2
Eye problems/disorders: Glaucoma	0.5	0.5	2.1	-0.1	-0.5	-0.7	0.6	1.4	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	0.8	0.7	0.6	1.1	-0.3	1.1
Arm predicted mass (left)	0.5	2.3	5.8	2.4	0.8	0.7	-0.1	-1.2	2.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	-0.4	0.4	0.3	1.2	-1.1	0.2
Worry (Nagel 2018)	0.4	0.8	3.5	0.1	0.4	0.5	0.9	-1.9	0.3
Age at First Birth	0.4	0.6	3.1	0.3	-0.4	-0.5	-0.0	1.8	0.3
Coronary Artery Disease (CAD)	0.4	0.4	1.1	-1.0	0.2	-0.1	0.2	1.1	-0.5
Triglycerides	0.4	0.6	1.7	-1.3	0.1	0.1	-0.5	-0.0	-1.3
Systolic Blood Pressure	0.4	1.8	6.1	-0.6	-1.4	-1.1	2.5	0.1	-0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-0.6	-1.1	-0.9	-0.4	0.3	-1.2
Chronotype (morning person)	0.4	0.8	2.8	-0.1	0.8	0.7	1.7	-0.9	0.5
Average weekly spirits intake	0.4	0.5	1.7	0.2	0.8	0.8	-1.3	0.3	0.2
Medication for hormone replacement therapy	0.4	0.4	1.4	0.1	0.6	0.7	0.4	-1.2	0.3
Maternal smoking around birth	0.4	0.5	2.0	0.4	0.4	0.2	-1.4	0.9	0.1
High blood pressure	0.4	1.1	3.0	1.7	1.0	1.2	-0.1	-0.6	0.8
Pain all over the body in last month	0.4	0.4	1.2	-0.1	-0.3	-0.4	-1.1	1.1	-0.4
Impedance of arm (right)	0.4	2.1	5.6	-2.4	-0.4	-0.2	-1.1	0.7	-2.2
Hair/balding pattern: Pattern 4	0.4	0.9	3.8	-0.3	-0.3	-0.2	2.0	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	0.7	1.2	1.0	-0.5	-0.3	0.6
Medication: Paracetamol	0.4	0.6	1.0	0.9	0.6	0.7	1.0	0.1	0.9
Angina (self-reported)	0.4	0.5	0.7	0.7	0.8	0.8	0.4	0.5	0.8
Mean time to correctly identify matches	0.4	0.7	1.9	-0.9	-0.4	-0.4	1.4	-0.0	-1.1
Heart disease (mother)	0.4	0.5	1.5	-0.3	-0.5	-0.4	1.2	-0.6	-0.8
Leg pain on walking	0.4	0.5	1.2	0.9	-0.5	-0.6	1.1	0.5	0.7
Leg fat-free mass (right)	0.4	2.0	5.1	1.4	1.2	1.1	-0.1	-2.3	1.5
Average weekly red wine intake	0.4	0.6	1.7	0.5	0.8	0.9	-0.2	-1.3	0.5
Medication: Gliclazide	0.4	0.5	1.1	-1.0	-0.1	0.0	-0.2	0.9	-0.9
Leg predicted mass (right)	0.4	1.9	4.9	1.4	1.2	1.1	-0.1	-2.2	1.5
Commuting to job workplace: Public transport	0.4	0.5	2.0	0.3	-0.0	-0.1	-0.8	1.4	-0.0
Basal metabolic rate	0.4	2.3	4.5	2.1	0.9	0.9	-0.0	-1.9	2.0
Arm fat-free mass (left)	0.4	2.1	5.3	2.3	0.7	0.6	0.1	-1.2	2.3
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.3	0.9	0.9	0.4	-0.5	0.8
Breast Cancer	0.3	0.7	2.3	-0.4	0.6	0.8	0.4	-1.5	-0.7
Blood Platelet Count	0.3	3.0	6.1	1.5	1.7	1.2	2.1	1.0	2.5
Blood White Count	0.3	2.5	5.6	1.9	0.7	0.3	0.4	2.4	2.3
BMI	0.3	1.5	2.6	-1.3	-1.4	-1.5	0.7	0.4	-1.6
Smoking Status	0.3	0.7	3.6	0.0	-0.4	-0.4	-1.9	0.2	-0.2
Hand grip strength (left)	0.3	0.8	2.7	0.4	0.6	0.6	0.7	-1.6	0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.2	-0.5	0.2	-0.0	1.5	0.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.7	-0.2	0.1	0.2	0.8	-1.3	-0.2
Systolic blood pressure, automated reading	0.3	0.8	2.0	-0.3	-1.4	-1.2	0.7	0.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.8	0.4	0.7	-0.0	-0.4	0.5
Leg fat-free mass (left)	0.3	1.4	3.6	1.3	0.9	0.8	-0.0	-1.9	1.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.6	0.0	-0.3	-0.2	-1.3	0.1	-0.3
Body mass index (BMI)	0.3	1.2	2.1	-0.4	-1.4	-1.5	-0.5	1.0	-1.2
Leg predicted mass (left)	0.3	1.4	3.9	1.3	0.8	0.8	-0.0	-2.0	1.3
Trunk fat mass	0.3	1.1	1.8	-0.6	-1.2	-1.2	-1.1	0.6	-1.3
Past tobacco smoking	0.3	0.6	2.9	-0.5	0.3	0.3	1.7	-0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.6	0.7	0.6	0.8	0.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.6	0.1	-0.2	-0.2	1.9	-0.7	0.0
Financial difficulties in last 2 years	0.3	0.5	2.0	-0.8	0.0	-0.2	-0.1	1.4	-0.2
Mouth/teeth dental problems	0.3	0.5	0.6	0.7	0.6	0.7	-0.8	-0.8	0.6
Heart attack	0.3	0.4	0.8	0.7	0.5	0.4	0.9	-0.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	0.5	0.9	0.8	0.2	0.8	0.6
Pulse rate	0.3	0.5	1.4	-0.1	-0.7	-0.7	-0.7	1.2	-0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	0.8	0.0	0.1	-1.1	0.8	0.4
Impedance of arm (left)	0.3	1.4	4.0	-2.0	0.1	0.3	-0.7	-0.1	-1.9
Arm fat mass (right)	0.3	1.2	1.9	-0.6	-1.4	-1.4	-0.9	0.9	-1.3
Length of working week for main job	0.3	0.3	0.7	0.1	-0.8	-0.8	-0.0	0.9	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.3	-0.2	-0.4	-0.5	0.4	1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.3	1.0	0.9	-0.6	0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.3	0.9	0.9	-0.1	-0.5	-0.1
Leg fat mass (right)	0.3	1.1	1.9	-0.2	-1.4	-1.4	-0.8	1.1	-0.9
Pulse rate, automated reading	0.3	1.0	1.6	1.1	0.7	0.5	-1.2	1.0	1.3
Family relationship satisfaction	0.3	0.4	1.0	0.1	-0.6	-0.7	1.0	0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.8	0.4	0.4	-0.3	-0.3	0.8
Medication: Aspirin	0.3	0.3	0.7	-0.4	-0.5	-0.6	0.8	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.3	1.0	0.8	0.7	-0.5	1.1
Qualifications: nursing, teaching	0.3	0.4	1.3	0.3	0.6	0.3	1.1	-0.2	0.7
Medication: Atorvastatin	0.3	0.4	1.4	1.2	0.0	0.3	-0.7	0.2	0.5
Average weekly beer plus cider intake	0.3	0.4	1.0	-1.0	-0.3	-0.5	0.4	0.4	-0.7
Pain experienced in last month	0.3	0.5	1.5	0.5	0.2	0.3	0.8	-1.2	0.6
Alcohol drinker status: Previous	0.3	0.4	1.6	0.1	0.4	0.4	1.3	-0.4	0.2
Leg fat mass (left)	0.3	1.0	1.7	-0.1	-1.3	-1.3	-1.0	1.1	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.6	1.6	0.7	0.6	0.6	-1.3	-0.7	0.3
Reaction Time	0.2	0.5	2.2	-0.5	-0.3	-0.4	1.5	0.1	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	1.2	-0.1	-0.4	-0.4	1.1	-0.0	0.0
LDL Cholesterol	0.2	0.3	0.7	0.1	0.8	0.7	-0.5	-0.3	0.4
Blood Red Count	0.2	2.0	4.5	-2.1	-1.2	-1.2	0.3	-0.3	-2.1
Waist Hip Ratio (WHR)	0.2	0.9	2.4	-0.4	-0.9	-0.9	1.6	1.0	-0.7
Medication: Metformin	0.2	0.3	0.6	-0.5	-0.6	-0.5	0.7	0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.3	0.8	0.7	-0.0	0.5	0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	-0.3	-0.5	-0.6	-0.5	-0.4	-0.5
Had menopause	0.2	0.3	0.4	-0.7	-0.2	-0.2	0.6	-0.4	-0.7
Qualifications: None of the above	0.2	0.5	1.3	-1.0	-0.4	-0.3	-0.6	0.3	-1.1
Medication: Simvastatin	0.2	0.2	0.5	0.0	0.7	0.6	0.7	-0.2	-0.2
Worrier / anxious feelings	0.2	0.4	1.6	0.4	0.5	0.6	-1.3	0.0	0.4
Happiness	0.2	0.2	0.7	0.3	-0.2	-0.2	0.8	-0.3	0.5
Medication: Cholesterol lowering	0.2	0.4	1.1	1.1	0.4	0.4	0.1	0.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.9	-0.6	-0.7	-0.3	-0.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.9	0.2	0.3	0.1	1.4	-0.4	0.7
Medication: Amlodipine	0.2	0.2	0.6	-0.1	-0.8	-0.7	0.1	0.4	-0.3
High blood pressure (siblings)	0.2	0.4	0.8	-0.3	0.6	0.6	0.9	-0.6	-0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.6	-0.3	-0.1	-0.4	-0.2	1.3	-0.3
Whole body fat mass	0.2	1.0	1.5	-0.5	-1.2	-1.2	-0.9	0.8	-1.1
Comparative height size at age 10	0.2	0.9	2.0	0.7	0.7	0.5	0.8	-1.1	1.4
Loneliness, isolation	0.2	0.3	1.2	-0.1	0.2	0.3	0.3	1.1	0.5
Medication: Aspirin	0.2	0.3	0.6	-0.3	-0.4	-0.5	0.7	0.8	-0.3
Arm fat mass (left)	0.2	1.0	1.5	-0.4	-1.2	-1.2	-1.0	0.8	-1.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	1.0	-0.1	-0.1	-0.0	0.1	0.9
Medication: Lisinopril	0.2	0.3	1.3	0.5	-0.1	-0.3	0.4	1.1	0.4
Ever smoked	0.2	0.3	1.2	0.6	-0.1	-0.3	-1.1	0.4	0.4
Diastolic blood pressure, automated reading	0.2	0.6	2.8	0.2	-0.1	-0.1	1.7	-0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.5	0.7	0.6	0.1	0.5	0.4
Heart disease (siblings)	0.2	0.3	0.6	-0.8	-0.5	-0.4	-0.0	0.2	-0.8
Impedance of whole body	0.2	1.2	3.2	-1.8	-0.2	-0.1	-0.6	0.9	-1.6
Ovarian Cancer	0.1	0.1	0.2	-0.4	0.5	0.5	-0.1	0.0	-0.1
Rheumatoid Arthritis	0.1	0.1	0.2	0.2	-0.5	-0.4	-0.4	0.3	-0.3
Schizophrenia (2014)	0.1	0.1	0.4	0.1	0.2	0.2	-0.6	-0.5	-0.2
Heel T-Score	0.1	0.7	1.8	-0.4	-1.3	-1.1	-0.0	0.2	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.9	-0.6	-0.2	-0.4	1.0	0.3	-0.0
Hair Pigment	0.1	3.4	8.1	-1.8	-1.3	-1.6	2.8	1.9	-1.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	-0.8	0.1	0.3	0.2	0.0	-0.5
Impedance of leg (right)	0.1	0.6	2.8	-0.4	-0.4	-0.4	-0.2	1.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.1	-0.7	-0.5	0.5	0.1	-0.2
Impedance of leg (left)	0.1	0.6	2.7	-0.6	-0.4	-0.3	-0.4	1.6	-0.4
Waist circumference	0.1	0.5	1.2	0.3	-1.1	-1.0	-0.4	0.7	-0.4
Alcohol usually taken with meals	0.1	0.2	0.6	0.4	-0.8	-0.6	-0.3	-0.3	0.0
Diabetes (self-reported)	0.1	0.2	0.3	0.5	0.4	0.6	0.2	0.1	0.3
Medication: Ramipril	0.1	0.1	0.4	-0.3	0.1	0.2	-0.0	-0.6	-0.6
Weight	0.1	0.4	1.0	1.0	-0.1	-0.0	-0.7	-0.8	0.6
Hip circumference	0.1	0.3	0.6	0.8	-0.2	-0.2	-0.7	-0.5	0.4
Father’s age at death	0.1	0.1	0.5	-0.3	0.1	-0.1	0.7	-0.4	-0.1
Comparative body size at age 10	0.1	0.4	0.8	-0.3	-0.9	-0.8	-0.4	-0.4	-0.7
Alcohol intake frequency.	0.1	0.2	0.6	-0.5	-0.2	-0.3	-0.2	0.8	-0.2
Overall health rating	0.1	0.3	1.0	0.4	-0.1	-0.1	1.0	0.7	-0.0
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	0.4	0.3	0.5	0.3	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.5	0.4	0.5	0.5	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.5	0.2	0.3	-0.1	-0.2	0.2
Current tobacco smoking	0.0	0.0	0.1	-0.3	0.0	0.0	-0.3	-0.1	0.0
Depression (self-reported)	0.0	0.0	0.2	0.5	0.0	-0.0	0.1	0.1	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	-0.1	0.0	0.0	-0.1	-0.1
Medication: Blood pressure	0.0	0.1	0.2	0.2	-0.1	0.0	-0.1	0.5	-0.1
Had major operations	0.0	0.1	0.1	-0.0	-0.2	-0.2	0.3	-0.2	-0.2
Illnesses of father: Heart disease	0.0	0.1	0.1	0.1	0.3	0.4	-0.3	0.0	-0.2
Smoking status: Current	0.0	0.0	0.1	-0.3	0.2	0.1	-0.2	0.0	0.1

Hub : Genes

IL18RAP

Models

Trait associations