TWAS hub - IL1RL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.2450	0.0840	3.7e-03	0.124	NA	0.170	NA	0.213	7.6e-04	NA	7.6e-05	NA	8.7e-06
2	GTEx	Lung	0.3112	0.0624	2.2e-10	0.202	NA	0.139	NA	0.202	2.2e-15	NA	8.8e-11	NA	2.3e-15
3	NTR	Blood	0.0394	0.0110	5.5e-11	0.042	0.036	0.037	0.037	0.040	1.4e-13	7.0e-12	6.1e-12	5.5e-12	7.7e-13
4	ROSMAP	Brain Pre-frontal Cortex	0.4504	0.0460	0.0e+00	0.509	0.463	0.514	0.506	0.511	5.5e-76	1.4e-66	4.7e-77	2.3e-75	3.1e-76
5	TCGA	Bladder Urothelial Carcinoma	0.0430	0.0240	1.7e-03	0.026	0.031	0.033	NA	0.033	2.7e-03	1.2e-03	8.6e-04	NA	8.0e-04
6	TCGA	Breast Invasive Carcinoma	0.0244	0.0146	1.0e-03	0.007	0.012	0.005	NA	0.005	1.1e-02	1.5e-03	3.0e-02	NA	3.2e-02
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0395	0.0208	4.3e-04	0.037	0.037	0.034	NA	0.041	4.8e-05	4.3e-05	1.0e-04	NA	1.7e-05
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0807	0.0300	2.6e-08	0.081	0.083	0.083	NA	0.081	1.8e-09	1.2e-09	1.2e-09	NA	1.9e-09
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1810	0.0650	2.0e-08	0.065	0.154	0.149	NA	0.147	1.5e-04	3.7e-09	6.8e-09	NA	8.7e-09
10	TCGA	Brain Lower Grade Glioma	0.1294	0.0394	0.0e+00	0.201	0.174	0.198	NA	0.198	2.0e-22	2.3e-19	4.5e-22	NA	4.9e-22
11	TCGA	Lung Adenocarcinoma	0.0269	0.0155	2.7e-03	0.008	0.016	0.012	NA	0.008	3.4e-02	4.7e-03	1.3e-02	NA	3.3e-02
12	TCGA	Pancreatic Adenocarcinoma	0.1930	0.0910	2.3e-05	0.053	0.097	0.084	NA	0.067	3.0e-03	7.1e-05	2.1e-04	NA	8.8e-04
13	TCGA	Thyroid Carcinoma	0.0550	0.0270	5.9e-04	0.032	0.017	0.027	NA	0.024	3.9e-04	8.6e-03	9.7e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Blood Eosinophil Count	118.3	911.3	1772.4	-10.8	-8.3	-2.4	-11.1	-35.0	-33.4	-39.4	-38.5	-39.7	-9.7	-42.1	-39.3	-34.2
Allergy	87.0	200.1	380.2	1.1	0.4	1.8	2.1	15.4	16.0	18.9	19.5	18.7	1.6	19.2	17.6	18.2
Respiratory disease	79.8	177.6	331.2	-2.2	-1.9	-0.4	-3.8	-14.4	-15.4	-17.4	-18.1	-17.9	-3.4	-18.2	-16.8	-16.3
Allergy or Eczema	74.2	195.4	380.2	1.9	2.6	-4.7	1.0	-14.8	-15.3	-19.5	-19.4	-17.8	1.5	-18.7	-16.6	-18.8
Asthma (self-reported)	73.6	146.5	278.9	-2.9	-1.6	-1.3	-3.2	-13.1	-13.4	-16.1	-16.4	-16.0	-2.8	-16.7	-15.2	-15.1
Asthma	73.3	144.5	275.6	-2.7	-1.4	-1.4	-3.0	-12.9	-13.3	-16.0	-16.4	-16.0	-2.5	-16.6	-15.0	-15.1
Hayfever, allergic rhinitis or eczema	64.7	140.5	272.2	0.4	1.2	-2.6	-0.2	-12.6	-13.2	-16.2	-16.5	-15.4	0.1	-16.0	-14.4	-15.8
Wheeze or whistling in the chest in last year	39.9	71.1	134.6	-1.1	-1.8	-0.3	-2.7	-9.5	-9.9	-10.7	-11.1	-11.5	-2.3	-11.6	-10.8	-9.9
Medication: Ventolin 100micrograms inhaler	38.0	48.8	96.7	-1.5	-1.5	-1.9	-2.3	-7.7	-7.5	-9.5	-9.1	-9.0	-1.9	-9.8	-9.0	-8.3
Hayfever/allergic rhinitis (self-reported)	37.5	49.7	89.9	-2.3	-2.3	-0.4	-3.2	-8.4	-8.2	-8.9	-8.9	-9.3	-2.9	-9.5	-9.3	-7.7
Medication: Seretide 50 evohaler	14.8	17.0	32.4	-2.3	-2.4	-0.7	-2.8	-4.8	-4.4	-5.0	-4.8	-5.0	-2.5	-5.7	-5.5	-4.2
Crohns Disease (2017)	8.5	18.7	49.3	5.2	5.9	-7.0	6.7	2.3	3.1	-0.7	1.0	3.2	6.8	1.8	3.3	-0.8
Taking other prescription medications	8.2	12.7	29.9	1.0	-0.1	0.6	-0.5	-3.0	-3.9	-4.4	-5.5	-5.2	-0.5	-4.8	-3.7	-5.1
Chest pain or discomfort	8.1	11.7	25.6	-1.3	-1.2	1.2	-1.5	-3.2	-4.1	-3.9	-4.7	-5.1	-1.4	-4.5	-4.0	-4.0
Irritable Bowel Disease (IBD)	7.9	18.7	44.6	5.5	5.6	-6.4	6.6	3.0	3.4	-0.0	1.3	3.4	6.7	2.3	3.6	-0.8
Lung FEV1/FVC ratio	7.8	39.5	82.6	3.2	2.9	-4.0	3.8	5.3	7.6	6.6	8.4	9.1	3.9	7.9	7.6	6.8
Crohns Disease (2012)	7.1	11.5	38.9	4.1	4.6	-6.2	5.0	1.4	2.4	-1.0	0.6	2.2	5.2	0.8	2.2	-0.9
Number of self-reported non-cancer illnesses	6.3	11.0	24.2	0.8	0.2	-0.0	-0.2	-2.9	-3.5	-4.2	-4.8	-4.9	-0.2	-4.7	-3.5	-4.7
Medication: Atenolol	5.5	6.9	15.9	0.5	-0.7	0.6	-0.5	2.2	2.4	3.8	3.9	3.4	-0.5	3.6	2.8	4.0
Emphysema/chronic bronchitis	4.7	5.3	11.1	-1.0	-1.6	1.0	-2.0	-3.3	-3.2	-2.1	-2.3	-2.7	-1.9	-2.4	-3.2	-1.4
Ulcerative Colitis	4.2	6.1	14.7	3.4	2.7	-3.8	3.5	2.0	2.2	0.2	0.9	1.9	3.6	1.3	2.2	-0.4
Ulcerative Colitis (UC)	3.9	7.2	15.4	3.9	3.2	-3.2	3.9	2.6	2.4	0.5	0.9	2.1	3.9	1.7	2.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	3.8	6.0	13.9	3.3	3.1	-2.9	3.5	2.2	3.0	0.2	1.0	1.5	3.7	0.4	2.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.6	4.2	8.0	0.9	0.5	-0.5	0.4	-1.9	-2.3	-2.8	-2.8	-2.8	0.5	-2.8	-2.1	-2.8
Townsend deprivation index at recruitment	3.5	4.9	11.2	0.9	0.4	-2.5	0.4	-2.9	-2.3	-3.3	-2.8	-1.9	0.7	-2.5	-2.7	-2.5
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.3	8.6	2.9	2.7	-2.1	2.7	0.1	-0.1	-2.0	-2.0	-1.2	2.8	-1.7	0.0	-2.8
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	8.1	-1.3	-1.3	0.1	-1.3	-2.8	-2.3	-2.2	-2.1	-2.2	-1.1	-2.6	-2.8	-1.5
Coronary Artery Disease (CAD)	3.0	3.5	9.2	1.1	1.9	-0.5	1.7	-1.2	-1.6	-2.3	-2.8	-1.8	1.7	-1.8	-1.6	-3.0
Had other major operations	3.0	3.6	7.7	-0.1	1.3	-1.0	1.1	-1.8	-1.6	-2.7	-2.5	-2.4	1.3	-2.8	-1.7	-2.5
Prostate Cancer	2.8	3.9	9.2	3.0	1.9	-1.3	1.9	2.1	2.3	1.3	1.6	2.2	1.7	2.0	2.5	0.8
Wears glasses or contact lenses	2.7	3.1	7.9	-0.1	-1.2	1.1	-1.2	0.9	1.5	2.4	2.6	2.0	-1.3	2.1	1.6	2.8
Pain type(s) experienced in last month: Hip pain	2.7	3.4	8.5	-0.9	-2.6	1.6	-2.9	-2.1	-1.9	-0.5	-0.8	-1.6	-2.8	-1.3	-2.1	-0.1
Financial difficulties in last 2 years	2.6	3.5	6.6	1.1	0.6	-0.8	0.6	-2.1	-2.4	-2.6	-2.6	-1.9	0.8	-2.0	-2.4	-2.4
Number of treatments/medications taken	2.5	4.5	10.9	1.0	-0.3	0.1	-0.7	-2.1	-2.5	-2.3	-3.0	-3.3	-0.7	-2.9	-2.2	-2.5
Loud music exposure frequency	2.5	2.7	5.8	-1.0	-0.6	-0.9	-0.6	-2.0	-1.6	-2.4	-1.8	-1.8	-0.4	-2.4	-2.2	-1.8
Ever had bowel cancer screening	2.5	2.9	5.3	1.6	1.5	-1.8	1.6	1.4	2.3	1.1	1.7	2.0	1.6	1.5	2.3	1.1
Osteoarthritis (self-reported)	2.5	3.2	6.4	-0.4	0.6	-0.3	0.5	1.9	2.2	2.3	2.5	2.5	0.4	2.2	2.3	2.2
Age at First Birth	2.3	3.4	7.3	0.1	-0.4	0.4	-0.6	-1.8	-2.2	-2.1	-2.4	-2.7	-0.5	-2.6	-2.2	-2.3
Severe depression (siblings)	2.3	2.6	5.5	1.8	2.3	-0.8	2.4	2.3	1.4	0.7	0.6	1.2	2.2	1.2	1.9	-0.3
Qualifications: CSEs or equivalent	2.3	3.0	6.1	-1.6	-2.1	-0.6	-1.8	-2.3	-1.4	-2.0	-1.4	-1.5	-1.4	-2.2	-2.5	-0.9
Long-standing illness, disability or infirmity	2.3	3.5	7.7	1.0	-0.2	0.6	-0.3	-1.7	-2.4	-2.0	-2.8	-2.8	-0.4	-2.3	-2.0	-2.5
Noisy workplace	2.2	2.7	6.0	1.1	1.0	-1.4	1.0	-0.9	-1.0	-2.3	-2.0	-2.0	1.2	-2.5	-1.1	-2.5
Average weekly fortified wine intake	2.1	2.4	5.5	1.6	1.5	-0.6	1.7	2.4	2.2	1.0	0.9	1.3	1.7	1.2	2.3	0.1
Mouth/teeth dental problems: Loose teeth	2.0	2.4	5.8	0.4	1.2	-2.3	1.2	-1.3	-1.1	-2.4	-1.7	-0.9	1.4	-1.5	-1.4	-2.0
Lupus	1.9	2.9	4.9	1.6	1.6	-1.0	2.1	2.2	1.8	1.3	1.3	1.9	2.0	1.8	1.9	0.5
Fluid intelligence score	1.9	3.9	8.5	-1.3	-2.2	2.5	-2.0	0.9	0.3	2.7	2.1	1.5	-2.1	2.3	0.6	2.9
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.7	-1.5	-0.2	1.2	-0.5	2.0	2.2	2.0	1.6	1.6	-0.9	1.6	1.8	1.3
Medication for cholesterol	1.9	2.9	6.9	-2.1	-1.0	-1.0	-1.0	-2.6	-2.5	-1.7	-1.4	-1.5	-0.9	-1.6	-2.4	-0.7
Financial situation satisfaction	1.9	2.3	5.1	0.9	1.5	-1.3	1.5	-0.9	-1.3	-1.9	-1.8	-1.3	1.6	-1.5	-1.3	-2.3
Illnesses of father: High blood pressure	1.9	2.4	5.3	2.3	1.8	0.7	1.8	2.3	1.0	1.4	0.6	1.0	1.5	1.9	1.8	0.4
Depression (Nagel 2018)	1.8	2.6	5.0	1.5	1.0	0.2	1.1	2.1	1.7	2.0	1.8	1.8	1.0	2.0	2.2	1.4
Mother’s age at death	1.8	2.3	4.4	-2.1	-2.0	-0.5	-2.0	-0.8	0.2	1.0	1.7	1.5	-2.0	1.3	-0.1	2.1
Basal cell carcinoma (self-reported)	1.8	2.1	5.2	-2.1	-2.1	1.8	-2.2	-0.2	-0.2	1.1	1.0	0.2	-2.3	0.5	-0.2	1.7
Verbal and Numeric Reasoning (VNR)	1.7	4.0	8.4	-1.6	-1.3	2.8	-1.3	1.7	1.2	2.9	2.3	1.7	-1.5	2.4	1.4	2.8
Primary Biliary Cirrhosis	1.7	2.5	5.7	2.4	2.0	-1.1	1.7	1.3	1.5	1.0	1.0	1.4	1.5	1.9	1.9	0.6
Loneliness, isolation	1.7	2.3	4.8	1.4	0.7	-0.2	0.8	-1.0	-1.8	-1.9	-2.2	-1.8	0.9	-1.8	-1.7	-2.0
Intelligence (Savage-Jansen 2018)	1.6	4.8	14.4	-1.7	-2.5	3.8	-2.4	0.1	-0.5	2.7	1.7	1.2	-2.6	2.4	0.0	2.9
Mean Putamen Volume	1.6	1.8	3.6	0.8	-0.0	-1.1	0.0	-1.7	-1.5	-1.9	-1.5	-1.5	0.2	-1.9	-1.8	-1.2
Diabetes (father)	1.6	2.0	5.1	2.2	1.1	0.0	1.4	2.3	2.0	0.9	0.9	0.8	1.5	0.5	1.9	0.3
Unable to work because of sickness or disability	1.6	2.1	3.9	1.4	1.8	-1.9	1.9	-0.7	-0.8	-1.7	-1.4	-0.9	2.0	-1.1	-0.6	-1.7
Neuroticism (Nagel 2018)	1.5	3.5	8.6	1.9	1.0	2.2	0.9	2.9	1.6	2.5	1.5	1.4	0.6	2.3	2.5	1.4
HbA1C	1.5	1.6	4.3	0.3	0.5	1.5	0.2	-0.3	-1.6	-1.3	-1.8	-2.1	0.1	-1.5	-1.1	-1.7
Schizophrenia (2018)	1.4	2.9	7.0	0.2	-0.5	1.5	-0.5	1.8	1.3	2.6	2.3	1.8	-0.8	2.3	1.8	2.4
Alzheimer’s Disease (including proxy)	1.4	2.1	5.1	-2.3	-1.6	1.9	-2.1	-1.4	-1.6	0.5	-0.0	-0.3	-2.3	0.5	-1.1	0.4
Alcohol usually taken with meals	1.4	2.3	10.2	-3.2	-2.0	1.0	-2.3	-0.4	0.3	0.8	1.0	0.3	-2.3	0.0	-0.2	1.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.4	0.9	1.6	-1.1	1.7	-0.0	-0.5	-1.5	-1.4	-0.8	1.8	-1.0	-0.5	-2.1
Gout (self-reported)	1.4	1.9	4.4	-0.3	-0.6	-0.3	-0.0	1.4	1.5	1.7	1.9	2.1	-0.0	1.9	1.6	1.6
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.1	1.5	1.6	-0.5	1.3	0.1	-0.4	-1.5	-1.7	-1.3	1.2	-1.2	-0.4	-2.0
Illnesses of siblings: Diabetes	1.4	1.8	4.7	0.1	0.7	0.6	0.4	1.1	1.2	1.9	1.6	1.7	0.3	2.2	1.8	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	3.3	1.3	1.6	-0.2	1.4	1.8	1.4	1.3	1.2	1.4	1.2	1.4	1.6	0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.1	0.1	-0.4	-1.7	-0.4	-2.2	-1.6	-1.6	-1.0	-0.7	-0.1	-1.1	-1.8	-0.8
Medication: Ramipril	1.3	1.7	3.8	-0.5	-0.4	-0.4	-0.5	1.4	1.9	1.5	1.7	1.9	-0.5	1.6	1.4	1.4
Medication: Simvastatin	1.3	2.0	4.8	0.9	1.2	-0.6	1.3	1.8	1.8	1.4	1.3	1.4	1.2	1.6	2.2	0.9
Number of full brothers	1.3	1.7	4.8	2.2	1.9	1.1	1.6	0.9	-0.1	-0.6	-1.2	-1.4	1.4	-0.7	0.4	-1.5
Heart disease (mother)	1.3	1.6	4.0	1.5	0.5	-0.7	0.3	1.5	2.0	1.3	1.5	1.6	0.4	1.1	1.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.2	-0.9	0.1	1.3	0.3	-0.2	-1.2	-1.1	-1.7	-1.7	0.3	-1.4	-1.2	-1.8
Alcohol drinker status: Never	1.3	1.6	5.7	2.4	1.5	-1.8	1.6	0.7	1.0	-0.5	-0.3	0.2	1.8	-0.3	0.8	-1.0
Diastolic blood pressure, automated reading	1.3	3.9	7.6	2.7	2.4	-0.4	2.4	2.8	2.4	1.3	1.1	1.1	2.3	1.2	2.7	0.3
Blood White Count	1.2	9.1	23.0	0.2	-0.4	1.5	-0.2	-2.1	-3.7	-3.4	-4.5	-4.8	-0.1	-4.0	-3.2	-4.0
Chronotype (morning person)	1.2	2.8	7.8	2.8	2.5	-0.3	2.5	2.2	1.4	0.3	0.2	0.7	2.2	0.8	1.6	-0.9
Diabetes (mother)	1.2	1.5	4.7	1.8	1.6	-1.5	2.0	-0.4	0.0	-1.0	-0.7	-0.3	2.2	-0.6	-0.2	-0.9
Lung cancer (father)	1.2	1.4	2.7	-1.4	-0.8	1.5	-1.1	-0.3	-0.7	-1.0	-1.3	-1.5	-1.0	-1.6	-1.1	-1.1
Length of working week for main job	1.2	1.4	3.0	0.8	0.1	0.3	-0.2	-0.8	-1.1	-1.5	-1.6	-1.7	-0.2	-1.7	-1.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.5	1.0	1.8	-0.8	2.1	1.4	0.6	-0.4	-0.4	-0.4	2.1	-0.5	0.9	-0.9
Supplements: Vitamin C	1.2	1.4	3.9	1.3	2.0	-0.6	1.8	1.4	1.3	-0.2	-0.0	0.2	1.8	-0.2	1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	5.3	0.8	1.0	0.6	0.9	-1.1	-2.2	-1.8	-2.3	-1.9	0.9	-1.5	-1.6	-2.2
Irritability	1.2	2.0	4.4	0.6	-0.6	1.3	-0.7	1.5	1.4	2.1	1.7	1.4	-0.7	1.8	1.6	2.0
Depressed Affect (Nagel 2018)	1.1	2.3	7.4	2.7	1.4	1.4	1.3	2.2	0.6	1.6	0.7	0.9	1.0	1.8	1.6	0.4
Alzheimer’s Disease (in mother)	1.1	1.3	5.1	-2.3	-1.0	1.7	-1.7	-0.8	-0.7	0.2	-0.2	-0.4	-1.8	0.1	-0.7	0.1
Relative age voice broke	1.1	1.6	4.2	1.0	1.0	-0.6	1.2	1.4	1.0	1.4	1.2	1.8	1.1	2.0	1.2	0.9
Serious illness, injury or assault to yourself	1.1	1.3	3.9	1.1	1.0	-1.8	1.7	1.2	1.0	-0.6	-0.3	0.2	2.0	-0.6	0.8	-0.8
Illnesses of siblings	1.1	1.6	3.5	-0.4	-0.4	-0.5	-0.4	-1.7	-1.6	-1.7	-1.5	-1.4	-0.3	-1.7	-1.9	-1.1
Average weekly champagne plus white wine intake	1.1	1.5	3.8	-2.0	-0.9	1.4	-1.5	-1.0	-0.7	-0.8	-1.0	-1.2	-1.6	-1.2	-1.2	-0.9
Worry (Nagel 2018)	1.0	2.2	4.8	0.5	0.4	0.4	0.5	2.2	2.0	1.8	1.7	1.8	0.4	1.8	2.0	1.5
Medication: Co-codamol	1.0	1.1	3.1	-0.2	-1.0	1.8	-1.5	0.4	-0.2	1.2	0.6	0.2	-1.8	1.0	0.4	1.2
Birth weight of first child	1.0	1.7	6.6	-2.6	-1.7	1.6	-1.5	-1.1	-1.4	0.4	0.3	-0.3	-1.6	0.2	-1.2	0.8
Birth weight	1.0	2.2	5.2	-1.3	-1.9	1.9	-1.6	-0.3	-0.2	1.7	1.6	1.1	-1.7	1.6	0.2	2.3
Qualifications: College or University degree	1.0	3.3	7.6	-2.0	-2.5	2.1	-2.7	-0.6	-0.5	1.6	1.3	1.0	-2.8	1.3	-0.5	2.2
Family relationship satisfaction	1.0	1.2	3.1	0.8	0.0	0.0	0.1	-0.4	-0.8	-1.5	-1.5	-1.6	0.2	-1.7	-1.1	-1.8
Average weekly red wine intake	1.0	1.5	5.5	-2.3	-1.3	0.8	-1.4	-0.3	-0.1	1.2	1.1	0.8	-1.6	1.0	-0.0	1.5
Osteoporosis (self-reported)	1.0	1.2	2.7	-0.8	-0.8	1.0	-0.8	-1.3	-1.5	-0.9	-1.1	-1.6	-1.0	-1.1	-1.4	-0.5
Number of operations (self-reported)	1.0	1.5	3.0	1.7	1.7	-1.1	1.6	0.9	0.8	-0.9	-0.9	-0.6	1.6	-1.1	0.6	-1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.8	-1.2	-1.7	1.4	-1.5	-0.2	-0.2	1.1	0.9	0.1	-1.6	0.5	0.0	1.2
Fractured/broken bones in last 5 years	1.0	1.3	3.6	1.2	1.3	-1.9	1.5	-0.9	-0.9	-1.1	-0.8	-0.3	1.6	-0.4	-0.8	-0.9
Ever depressed for a whole week	1.0	1.2	2.6	-1.6	-1.5	-0.7	-1.2	-1.4	-0.7	-1.2	-0.6	-0.6	-0.9	-1.4	-1.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	5.8	0.3	-1.1	2.4	-0.9	0.8	0.0	1.1	0.4	-0.5	-1.1	0.4	0.6	0.9
Stomach or abdominal pain in last month	0.9	1.1	2.7	0.1	-0.3	0.3	0.1	-0.7	-0.8	-1.3	-1.5	-1.5	0.2	-1.6	-1.0	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.5	-0.9	-1.9	1.0	-1.8	-0.7	-0.4	0.8	0.9	0.6	-1.8	0.7	-0.5	1.5
Medication: Ibuprofen	0.9	1.1	2.9	1.7	1.1	1.2	1.0	1.1	0.4	1.3	0.7	0.4	1.0	1.1	1.2	0.8
Suffer from ‘nerves’	0.9	1.4	2.7	-0.2	-0.4	1.0	-0.4	1.3	1.0	1.6	1.5	1.5	-0.5	1.6	1.0	1.6
Hearing aid user	0.9	1.0	6.2	-0.3	-0.8	2.5	-1.3	-0.3	-0.9	0.7	-0.3	-1.0	-1.5	0.1	-0.2	0.5
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.1	-0.8	0.4	-1.2	0.4	-1.9	-1.7	-2.5	-1.9	-1.5	0.5	-2.1	-2.0	-1.7
Cholesterol lowering medication	0.9	1.3	3.5	1.4	1.2	-1.1	1.2	1.4	1.9	0.2	0.4	0.8	1.3	0.3	1.5	-0.3
Alcohol intake versus 10 years previously	0.8	1.2	2.9	-0.2	-1.0	1.1	-0.6	0.7	0.6	1.7	1.5	1.2	-0.5	1.5	0.9	1.6
Father’s age at death	0.8	1.0	2.8	0.0	-0.0	-0.1	-0.2	0.6	1.1	1.5	1.7	1.3	-0.1	1.1	1.0	1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	4.5	-0.5	1.2	1.7	1.6	2.1	1.3	2.0	1.6	1.7	1.4	2.0	1.7	1.1
Pulse rate, automated reading	0.8	2.7	6.7	0.3	-0.2	0.8	-0.3	-1.7	-2.6	-1.8	-2.3	-2.4	-0.3	-1.6	-2.1	-1.8
Medication: Gliclazide	0.8	0.9	1.9	0.5	0.1	-1.4	0.7	-1.1	-1.4	-1.1	-0.9	-0.7	0.8	-0.8	-1.1	-0.8
Miserableness	0.8	1.4	3.0	1.5	0.6	1.5	0.6	1.7	0.5	1.7	0.8	0.9	0.4	1.7	1.3	0.8
Guilty feelings	0.8	1.2	3.4	1.6	1.4	0.2	1.9	1.6	0.6	0.4	-0.0	0.1	1.8	0.3	1.2	-0.4
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.6	0.6	0.0	0.4	-1.0	-1.2	-1.2	-1.3	-1.0	0.4	-0.8	-1.3	-1.2
Medication: Lisinopril	0.8	1.0	2.3	-0.7	-0.3	0.6	-0.3	-0.6	-1.0	-1.0	-1.3	-1.5	-0.3	-1.5	-1.2	-1.3
Risk taking	0.8	1.2	3.5	1.2	1.9	0.1	1.6	-0.1	-0.8	-0.6	-1.2	-0.9	1.5	-0.5	-0.3	-1.4
Myopia	0.8	1.2	2.7	-1.1	-1.6	-0.4	-1.4	-1.4	-0.3	-0.9	-0.6	-1.0	-1.2	-1.6	-1.2	-0.3
Neuroticism (2016)	0.7	1.0	4.2	1.4	0.6	1.4	0.8	2.1	0.9	0.8	-0.1	-0.1	0.7	0.4	1.3	-0.4
Neuroticism	0.7	1.7	4.5	2.1	1.4	1.2	1.4	1.9	0.6	1.2	0.3	1.0	1.2	1.8	1.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	0.9	1.1	-0.8	1.1	-0.6	-0.7	-1.0	-1.1	-0.7	1.2	-0.7	-0.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	0.2	-0.0	0.3	0.4	1.0	0.9	1.1	1.4	1.2	0.4	1.1	1.2	1.4
Ever had hysterectomy (womb removed)	0.7	0.8	3.4	1.8	0.7	0.9	0.8	1.2	0.1	0.0	-0.6	-0.9	0.7	-0.4	0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.0	2.0	1.2	-0.6	1.6	0.1	-0.0	-0.5	-0.7	-0.2	1.7	-0.1	0.2	-0.9
Time employed in main current job	0.7	0.8	2.5	1.1	1.6	-1.5	1.0	-0.0	0.1	-0.9	-0.6	-0.2	1.1	-0.6	0.2	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.5	2.1	1.1	0.1	1.0	-0.7	-0.9	-0.9	-1.2	-1.1	1.1	-0.9	-0.5	-1.2
Falls in the last year	0.7	0.9	1.6	1.2	1.1	-0.6	1.2	-0.7	-0.5	-1.1	-0.9	-0.9	1.3	-1.0	-0.3	-1.0
Pulse rate	0.7	1.2	2.2	1.2	-0.0	0.0	-0.2	-1.2	-1.3	-1.3	-1.3	-1.5	-0.1	-1.4	-1.3	-1.1
Pulse wave reflection index	0.7	0.9	4.3	0.3	1.3	-2.1	1.3	-0.2	0.4	-0.7	-0.1	0.5	1.4	-0.3	0.0	-0.7
Age at first live birth	0.7	1.3	3.4	-1.8	-1.8	0.9	-1.8	-1.0	-0.7	0.3	0.3	-0.1	-1.8	0.2	-1.0	0.6
Medication: Allopurinol	0.7	1.0	2.1	1.4	0.6	0.0	1.1	1.2	0.7	1.0	0.8	1.1	1.1	1.2	1.3	0.5
Medication: Omeprazole	0.7	0.8	3.5	1.9	1.1	0.7	1.3	0.5	-0.3	-0.2	-0.7	-0.7	1.2	-0.3	0.3	-0.9
Number of full sisters	0.7	0.8	2.0	0.7	1.1	0.9	0.8	1.1	0.4	1.0	0.5	0.8	0.6	1.4	1.1	0.6
Breast cancer (self-reported)	0.7	0.8	2.7	0.9	0.8	-0.8	0.6	0.3	0.4	-1.2	-1.1	-0.7	0.7	-1.2	-0.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	6.3	2.5	1.5	1.0	1.4	0.8	0.2	1.2	0.9	0.7	1.4	1.2	1.0	0.8
Medication: Blood pressure	0.7	1.4	3.4	0.6	-0.3	0.8	-0.1	1.8	1.6	1.6	1.3	1.3	-0.2	1.5	1.6	0.9
Average weekly beer plus cider intake	0.7	1.0	2.9	1.5	1.4	-1.0	1.7	0.4	0.6	-0.4	-0.1	0.2	1.7	-0.1	0.5	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.2	0.1	-0.8	1.4	-0.7	-0.9	-1.5	0.4	-0.2	-0.5	-0.9	0.4	-0.7	0.2
Breast Cancer	0.6	1.4	4.1	-0.6	-0.2	-0.2	-0.2	0.1	0.9	1.3	1.9	2.0	-0.1	1.9	0.8	1.9
Schizophrenia (2014)	0.6	1.3	2.8	1.0	0.1	0.2	0.2	1.2	1.2	1.7	1.6	1.3	0.1	1.3	1.4	1.4
Triglycerides	0.6	1.0	3.5	-0.2	0.1	-1.1	0.4	0.3	1.1	0.9	1.2	1.9	0.3	1.6	0.9	1.0
Height	0.6	11.6	38.2	-5.0	-2.9	6.2	-3.0	0.5	-0.7	4.0	2.6	1.9	-3.5	3.8	0.5	4.0
Hypothyroidism (self reported)	0.6	1.3	3.3	1.7	1.7	-0.7	1.8	0.6	0.4	-0.6	-0.8	-0.3	1.8	-0.5	0.4	-1.4
Tanning	0.6	7.3	19.2	-3.8	-2.9	4.4	-3.4	-1.4	-2.6	-0.4	-1.6	-2.9	-3.5	-1.8	-2.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.4	0.9	-0.7	0.6	-0.5	1.0	0.8	1.2	0.9	0.6	-0.6	0.7	0.8	0.8
Hand grip strength (right)	0.6	1.6	6.2	-2.5	-1.1	2.4	-1.2	1.0	0.2	1.2	0.6	0.3	-1.5	0.7	0.5	0.9
High blood pressure	0.6	1.7	3.8	0.7	-0.9	1.1	-0.8	1.6	1.4	1.9	1.4	1.0	-1.0	1.5	1.6	1.3
Multivitamins +/- minerals	0.6	0.8	2.0	0.1	-0.5	1.4	-0.5	0.0	-0.9	-0.6	-1.3	-1.2	-0.6	-1.0	-0.8	-1.2
Had menopause	0.6	0.8	1.5	0.9	1.0	-0.7	1.0	0.7	0.9	0.5	0.8	1.0	1.0	0.8	1.2	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.9	-1.3	-1.6	1.2	-1.7	-1.1	-1.0	0.8	0.5	0.6	-1.7	1.0	-0.8	1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	1.9	-1.3	-1.4	0.8	-1.4	-1.0	-1.0	-0.5	-0.7	-1.0	-1.3	-0.8	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.3	-0.3	0.8	1.5	1.1	1.4	0.7	1.9	1.5	1.6	0.9	2.1	1.2	1.3
Hair/balding pattern: Pattern 4	0.6	1.5	3.7	0.0	0.3	-0.8	0.4	1.6	1.9	1.2	1.6	1.6	0.6	1.2	1.9	1.1
Medication: Paracetamol	0.6	1.0	3.1	1.8	0.9	0.4	1.2	0.7	-0.1	-0.6	-1.2	-1.0	1.3	-0.8	0.1	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.5	-0.2	0.0	-0.2	0.2	-1.3	-1.5	-1.5	-1.2	-0.9	0.3	-1.2	-1.6	-1.1
High blood pressure (siblings)	0.6	0.8	2.1	0.7	0.3	-0.7	0.4	0.7	0.9	1.0	1.2	1.4	0.4	1.3	1.0	0.9
Number of children fathered	0.6	0.7	1.5	-0.8	-0.2	-1.0	-0.4	0.8	1.2	0.8	1.2	1.0	-0.5	0.7	0.7	0.7
Neck or shoulder pain in last month	0.6	0.8	1.7	0.4	-0.6	-0.5	-0.5	-1.0	-1.0	-1.1	-1.0	-1.1	-0.4	-1.3	-1.1	-0.9
Age at last live birth	0.6	0.8	1.7	-1.1	-1.2	0.8	-1.2	-1.2	-1.1	-0.0	-0.2	-0.2	-1.3	0.3	-1.1	0.0
Medication: Paracetamol	0.6	0.9	3.8	1.9	1.0	1.0	1.0	0.9	0.3	-0.0	-0.8	-0.8	1.1	-0.5	0.5	-0.9
Age started oral contraceptive pill	0.6	0.8	2.7	0.4	0.7	0.4	0.8	1.0	0.6	1.1	0.7	1.1	0.6	1.6	1.1	0.5
Supplements: Calcium	0.6	0.7	2.4	1.0	0.9	-1.6	1.1	0.4	0.7	0.0	0.5	0.9	1.2	0.4	0.6	-0.0
Alcohol drinker status: Previous	0.6	0.7	1.6	0.9	1.0	-0.2	1.1	1.2	1.0	0.3	0.1	0.4	1.1	0.5	1.1	-0.4
LDL Cholesterol	0.5	0.8	1.8	-0.1	0.8	0.4	1.2	1.4	0.9	0.9	0.5	0.7	1.1	0.9	1.1	0.2
Blood Platelet Count	0.5	5.7	12.2	2.6	1.6	0.6	1.6	-1.1	-2.7	-2.8	-3.3	-3.4	1.4	-2.6	-1.6	-3.5
BMI	0.5	2.9	13.5	3.7	2.3	-1.7	2.2	1.0	1.5	-0.1	0.5	0.6	2.3	0.1	1.3	-0.6
Systolic Blood Pressure	0.5	2.3	7.3	0.7	1.4	-0.9	1.7	2.4	2.7	0.8	0.9	0.9	1.7	0.4	2.4	0.2
Sensitivity / hurt feelings	0.5	0.8	1.6	0.2	-1.2	1.3	-0.9	1.1	0.8	1.2	0.8	0.6	-0.9	0.6	0.5	0.9
Systolic blood pressure, automated reading	0.5	1.4	5.1	0.8	0.8	-0.5	0.9	1.7	2.3	1.0	1.2	0.9	0.9	0.5	1.9	0.6
Maternal smoking around birth	0.5	0.7	1.7	1.3	-0.5	0.2	-0.5	-1.3	-1.2	-0.8	-0.9	-0.7	-0.5	-0.5	-1.2	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.9	-1.2	0.0	-1.4	0.2	-1.1	-0.4	-0.9	-0.4	0.0	0.4	-0.5	-0.6	-0.4
Neuroticism score	0.5	1.0	2.2	1.2	0.1	1.3	0.4	1.5	0.6	1.3	0.6	1.0	0.3	1.4	0.9	0.7
Prospective memory result	0.5	0.6	2.6	-0.1	0.6	-1.6	1.1	-0.5	-0.0	-1.0	-0.6	-0.0	1.3	-0.5	-0.3	-0.7
Illnesses of mother	0.5	0.6	1.8	-0.9	0.1	1.0	0.2	-0.2	-1.3	-0.7	-1.0	-1.0	0.1	-0.6	-0.8	-0.8
Breastfed as a baby	0.5	0.6	1.9	1.2	1.4	-0.3	1.3	0.1	-0.7	0.1	0.2	0.4	1.2	0.7	0.2	0.3
Exposure to tobacco smoke outside home	0.5	0.7	1.6	0.5	-0.1	-0.9	0.1	-1.0	-0.6	-1.1	-1.1	-0.7	0.3	-0.9	-0.9	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-1.3	-1.0	-0.2	-0.8	-0.6	-0.4	0.7	0.8	0.9	-0.8	0.9	-0.5	0.8
Health satisfaction	0.5	0.7	2.8	-0.0	-0.5	1.7	-0.5	1.2	0.2	0.1	-0.5	-1.2	-0.5	-1.2	0.2	-0.6
Shortness of breath walking on level ground	0.5	0.5	2.4	-0.3	0.3	0.7	0.2	1.6	1.2	0.0	-0.3	-0.7	0.4	-0.9	0.9	-0.5
Mean time to correctly identify matches	0.5	1.0	2.0	0.4	0.4	-1.2	1.0	1.2	1.4	0.8	1.2	1.1	1.1	0.8	1.4	0.7
Alcohol intake frequency.	0.5	1.1	4.2	2.0	1.3	-0.8	1.7	0.8	0.5	-0.3	-0.3	-0.0	1.8	-0.0	0.9	-0.6
Knee pain experienced in last month	0.5	0.8	3.7	1.9	1.1	-0.8	1.1	-0.7	-0.6	-0.6	-0.4	-0.1	1.2	-0.1	-0.3	-0.6
Hypertension (Self-reported)	0.5	1.5	3.3	0.6	-1.1	1.2	-1.0	1.3	1.0	1.8	1.2	0.9	-1.2	1.4	1.2	1.4
Mineral and other dietary supplements	0.5	0.7	1.5	1.2	1.1	-1.1	1.2	0.2	0.1	-0.8	-0.5	-0.7	1.2	-0.8	0.1	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	-0.9	-0.9	-1.4	-0.9	-1.2	-0.2	-0.7	-0.4	-0.0	-0.8	-0.4	-0.8	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.3	-0.5	-0.1	1.8	-0.2	0.9	-0.2	1.1	0.6	-0.3	-0.3	0.5	0.8	1.1
Eye problems/disorders: Glaucoma	0.5	0.5	1.5	0.1	-0.5	-0.2	-0.5	-0.4	-0.4	-1.0	-0.9	-1.0	-0.3	-1.2	-0.9	-1.0
High cholesterol (Self-reported)	0.5	1.0	2.0	1.2	1.3	-1.4	1.3	0.9	1.3	-0.1	0.2	0.3	1.3	-0.0	1.1	-0.5
Medication: Atorvastatin	0.5	0.6	1.8	-0.0	-1.3	0.9	-1.3	-0.6	-0.4	-0.1	-0.4	-0.6	-1.3	-0.5	-0.6	0.0
Bipolar Disorder or Schizophrenia	0.4	1.0	2.4	0.0	-0.3	0.8	-0.3	0.8	0.7	1.6	1.4	1.0	-0.4	1.3	1.1	1.5
Major Depression (MDD)	0.4	0.5	3.5	1.9	0.3	0.0	0.4	0.7	0.1	0.7	0.2	0.2	0.3	0.6	1.0	0.3
Body Mass Index (BMI) (2010)	0.4	0.6	2.3	1.5	1.0	-0.2	1.0	0.6	0.3	-0.4	-0.6	-0.5	0.9	-0.5	0.2	-1.0
Fasting Glucose	0.4	0.4	1.1	-0.3	-0.8	0.9	-0.8	-0.5	-1.0	0.5	0.1	0.1	-0.9	0.7	-0.5	0.6
HDL Cholesterol	0.4	0.6	2.4	-0.5	-0.5	-0.1	-0.6	-0.7	-0.5	-0.9	-0.8	-1.2	-0.4	-1.5	-0.9	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.0	-0.9	-1.4	-1.0	-1.3	-0.2	0.6	0.5	0.9	0.8	-1.2	0.4	0.0	0.8
Hand grip strength (left)	0.4	0.9	4.6	-2.1	-0.9	0.9	-1.1	0.3	0.3	0.8	0.8	0.8	-1.2	0.7	0.2	0.9
Vitamin and mineral supplements	0.4	0.5	1.7	-1.0	-0.7	-1.3	-0.6	-0.8	0.2	0.2	0.9	0.7	-0.6	0.4	-0.1	0.9
Pack years adult smoking proportion	0.4	0.7	1.6	0.1	0.4	-1.1	0.7	0.5	1.3	0.6	1.2	0.9	0.9	0.4	0.8	0.8
Number of incorrect matches in round	0.4	0.6	1.7	-1.2	-1.3	-1.1	-1.2	-0.2	0.9	-0.1	0.4	0.5	-1.0	-0.4	-0.1	0.3
Nervous feelings	0.4	0.8	1.7	0.3	-0.4	1.0	-0.3	1.0	0.6	1.2	1.1	1.1	-0.4	1.2	0.7	1.3
Forced vital capacity (FVC)	0.4	1.4	10.5	-2.3	-0.1	3.2	-0.0	0.6	-0.6	0.8	-0.1	-0.3	-0.3	0.4	-0.4	-0.1
Qualifications: None of the above	0.4	0.8	1.9	0.6	1.0	-1.4	1.1	0.4	0.8	0.4	0.9	1.0	1.0	1.0	1.0	0.6
Mouth/teeth dental problems	0.4	0.6	1.7	-0.7	-1.1	1.1	-1.2	-0.3	-0.4	0.7	0.4	0.2	-1.3	0.4	-0.2	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.7	-1.1	-0.5	-1.1	-1.3	-0.9	-0.3	0.0	-0.1	-1.0	-0.2	-0.9	0.5
Exposure to tobacco smoke at home	0.4	0.4	1.1	-0.8	-0.8	1.0	-0.6	0.0	-0.0	-0.2	-0.3	-1.0	-0.6	-1.0	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.3	-1.0	-1.5	0.6	-1.4	-0.5	-0.4	0.3	0.2	0.4	-1.4	0.4	-0.6	0.5
Blood clot in the leg (DVT)	0.4	0.6	1.4	0.1	-0.3	0.4	0.1	0.8	1.0	1.0	1.2	0.6	0.2	0.5	1.0	1.1
Migraine (self-reported)	0.4	0.5	1.9	-0.0	-1.4	0.2	-1.0	-0.7	-1.0	0.4	0.3	0.1	-0.9	0.4	-0.6	0.8
Overall health rating	0.4	0.9	6.8	2.6	0.9	-0.0	0.8	0.9	0.9	0.2	0.1	-0.1	0.9	-0.2	0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	3.5	0.1	-0.3	-1.9	-0.5	-0.8	0.3	-0.3	0.4	0.6	-0.4	0.1	-0.0	0.5
Mood swings	0.4	0.7	3.4	1.8	0.1	1.1	0.4	0.9	0.2	1.1	0.7	0.6	0.3	0.9	0.7	0.7
Eye problems/disorders: Cataract	0.4	0.5	2.2	-0.7	-0.6	1.5	-0.9	-0.0	0.1	0.8	0.5	-0.0	-1.0	0.3	0.2	0.7
Medication: Aspirin	0.4	0.5	1.9	0.8	1.4	-0.5	1.1	0.4	0.8	0.1	0.2	0.1	1.0	0.0	0.9	-0.2
Smoking status: Current	0.4	0.6	2.0	-0.9	-0.8	-0.1	-0.7	-1.4	-1.4	-0.3	-0.2	-0.4	-0.6	-0.4	-1.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.2	1.5	0.5	0.1	0.8	1.0	0.6	0.5	0.4	0.2	0.8	0.3	1.0	-0.0
Pack years of smoking	0.4	0.6	1.4	0.0	0.5	-1.0	0.6	0.2	1.1	0.6	1.2	0.9	0.8	0.4	0.8	0.8
Rheumatoid Arthritis	0.3	0.4	1.2	-1.1	-1.0	-0.2	-1.0	0.0	-0.2	0.3	0.3	-0.0	-0.9	0.0	-0.0	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	0.4	-0.2	-1.0	-0.0	0.3	0.8	0.4	1.0	0.8	0.0	0.5	0.5	0.7
Smoking Status	0.3	0.8	2.1	-0.8	-1.5	0.1	-1.3	-1.0	-0.6	0.4	0.7	0.3	-1.2	0.3	-0.6	1.2
Cardiovascular Disease	0.3	0.9	4.0	0.4	-0.4	2.0	-0.7	1.4	0.6	1.4	0.4	-0.0	-0.9	0.8	1.1	0.5
Angina	0.3	0.4	1.1	1.0	0.9	0.3	0.9	0.6	-0.2	0.1	-0.5	-0.5	0.8	-0.0	0.3	-0.8
Supplements: Zinc	0.3	0.4	1.1	-0.2	-0.5	-1.0	-0.8	-0.8	0.0	-0.8	-0.2	-0.1	-0.6	-0.7	-0.7	-0.1
Current tobacco smoking	0.3	0.5	1.8	-0.9	-0.6	-0.2	-0.4	-1.4	-1.3	-0.4	-0.3	-0.4	-0.3	-0.4	-1.2	0.1
Supplements: Glucosamine	0.3	0.4	1.2	-0.3	-0.8	1.1	-1.0	-0.1	-0.2	0.6	0.3	0.1	-1.0	0.3	-0.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.2	1.5	0.9	0.4	0.6	-0.2	-0.6	-0.6	-0.8	-0.8	0.6	-0.6	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.5	0.3	0.2	-0.1	0.4	1.6	1.4	0.6	0.5	0.8	0.3	0.6	1.3	0.3
Arm fat percentage (right)	0.3	1.2	4.3	2.1	1.0	-2.0	1.2	0.1	1.2	-0.5	0.3	0.2	1.3	-0.4	0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	1.1	0.3	1.0	0.3	0.2	-0.2	0.5	0.3	-0.1	0.3	0.4	0.5	0.6
Medication: Lansoprazole	0.3	0.4	2.8	0.1	-0.7	-1.7	-0.5	-0.8	0.2	-0.2	0.5	0.6	-0.2	0.0	-0.2	0.4
Impedance of arm (left)	0.3	1.2	3.8	-1.8	-0.3	-1.9	0.0	0.0	0.6	0.4	0.8	2.0	0.1	1.6	0.4	0.8
Trunk predicted mass	0.3	1.5	12.9	-0.3	-0.8	3.6	-1.0	-0.0	-1.1	0.5	-0.2	-1.2	-1.2	-0.3	-0.6	0.2
Standing height	0.3	3.4	15.0	-3.2	-1.7	3.9	-1.8	0.0	-0.9	1.5	0.7	0.4	-2.1	1.4	-0.4	1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	1.0	-0.4	1.0	1.0	0.4	-0.3	-0.3	0.0	0.9	0.1	0.6	-0.6
Glaucoma (self-reported)	0.3	0.3	0.9	0.5	0.2	-0.9	0.3	-0.1	0.2	-0.8	-0.6	-0.5	0.5	-0.9	-0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	1.0	0.8	0.1	1.0	0.4	-0.2	-0.6	-1.1	-0.8	1.0	-0.7	0.0	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.1	8.6	-1.8	-0.3	2.9	-0.3	0.1	-1.1	0.7	-0.2	-0.3	-0.5	0.5	-0.5	0.0
Leg fat percentage (right)	0.3	1.2	4.0	2.0	1.0	-1.3	0.9	-0.0	0.5	-1.1	-0.5	-1.1	1.0	-1.5	0.2	-1.2
Comparative body size at age 10	0.3	0.9	1.7	1.3	-0.5	-0.2	-0.6	0.7	1.3	1.0	1.3	1.2	-0.6	1.0	0.9	1.3
Worry too long after embarrassment	0.3	0.5	2.9	0.4	-0.2	1.7	0.0	0.5	-0.2	1.0	0.5	0.5	-0.1	1.1	0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.2	-0.9	0.3	-1.0	-1.1	-0.8	0.0	0.0	0.1	-0.9	0.1	-0.7	0.4
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.1	0.7	-1.1	1.0	-0.0	0.1	-0.3	-0.0	0.5	1.0	0.3	0.1	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.4	1.4	-1.2	-0.9	-1.1	-0.6	-0.6	-0.2	-0.3	0.3	0.5	-0.7	0.2	-0.6	0.4
Medication: Aspirin	0.3	0.4	1.8	0.7	1.4	-0.5	1.0	0.2	0.6	-0.0	0.1	-0.0	1.0	-0.1	0.7	-0.3
Friendships satisfaction	0.3	0.4	1.0	0.9	0.6	0.5	0.8	1.0	0.2	0.6	0.3	0.4	0.8	0.7	0.7	0.2
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.3	-0.7	-0.2	-0.9	-1.0	-0.7	-0.1	-0.1	-0.5	-0.8	-0.5	-0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.9	-0.7	-0.7	1.4	-0.7	0.2	-0.3	0.3	-0.5	-0.3	-0.9	0.0	-0.2	-0.4
Medication: Bendroflumethiazide	0.3	0.4	2.9	-0.0	-0.1	-1.7	0.2	-0.0	0.8	-0.1	0.8	0.7	0.5	-0.1	0.2	0.4
Ever smoked	0.3	0.6	3.3	-1.8	-0.9	0.7	-0.8	-0.7	-0.6	0.1	-0.0	-0.5	-0.8	-0.5	-0.5	0.3
Leg fat percentage (left)	0.3	1.0	3.8	1.9	1.0	-1.1	0.9	0.1	0.6	-0.9	-0.4	-1.0	1.0	-1.3	0.3	-1.1
Commuting to job workplace: Cycle	0.3	0.4	1.8	-0.7	-0.4	0.3	-0.3	-0.9	-1.3	-0.3	-0.3	-0.5	-0.3	-0.2	-1.0	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.0	-0.5	0.6	-0.1	0.6	0.7	0.9	1.0	0.5	-0.0	0.4	0.7	1.0
Bipolar Disorder (2018)	0.2	0.3	0.9	-0.3	0.1	-0.6	0.2	-0.9	-0.4	-0.8	-0.6	-0.7	0.2	-0.8	-0.4	-0.6
Reaction Time	0.2	0.3	1.0	0.5	0.6	-0.9	0.9	0.5	0.4	-0.2	-0.0	-0.1	1.0	-0.2	0.3	-0.3
Ovarian Cancer	0.2	0.3	0.9	-0.7	-0.6	-0.1	-0.3	-0.8	-0.9	-0.4	-0.2	-0.1	-0.2	-0.1	-0.7	0.2
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.6	-0.8	-0.7	-0.6	-0.2	0.6	0.1	0.5	0.4	-0.5	0.1	0.2	0.3
Blood Red Count	0.2	2.1	5.7	0.2	0.4	-2.0	0.4	0.4	1.5	1.0	2.1	2.4	0.6	1.8	1.2	2.0
Lung FVC	0.2	1.1	6.3	-1.1	0.9	2.5	0.9	1.2	-0.0	1.3	0.5	0.1	0.6	0.9	0.6	0.3
Hair Pigment	0.2	4.3	17.0	4.1	2.7	-2.2	2.6	0.2	0.3	-1.8	-1.4	-0.8	2.8	-1.4	0.2	-2.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.5	0.4	-0.9	0.6	0.3	0.5	0.4	0.6	0.8	0.7	0.6	0.5	0.5
Hearing difficulty/problems: Yes	0.2	0.3	2.6	0.5	-0.3	1.6	-0.3	0.4	-0.4	0.5	-0.0	-0.7	-0.4	-0.2	0.1	0.1
Relative age of first facial hair	0.2	0.3	0.9	-0.5	0.0	-0.9	0.2	0.5	0.7	0.4	0.6	0.9	0.3	0.5	0.5	0.6
Medication for hormone replacement therapy	0.2	0.2	0.7	0.8	0.2	0.6	0.2	0.4	0.4	0.4	0.4	0.7	0.2	0.6	0.5	0.5
Medication: Metformin	0.2	0.2	1.2	-0.1	-0.6	-1.1	-0.6	0.2	0.5	-0.0	0.2	0.4	-0.6	0.1	0.1	-0.1
Impedance of leg (right)	0.2	1.2	2.4	-1.5	0.3	-0.5	0.2	-0.7	-1.0	-1.4	-1.6	-1.4	0.2	-1.4	-1.1	-1.4
Trunk fat percentage	0.2	1.0	3.7	1.6	0.9	-1.9	1.0	0.1	1.2	-0.1	0.7	0.8	1.1	0.2	0.8	0.0
Fed-up feelings	0.2	0.4	2.1	0.8	0.1	1.5	0.1	0.4	-0.6	0.7	-0.2	-0.1	-0.1	0.9	0.0	0.0
Age when periods started (menarche)	0.2	0.6	2.3	1.5	1.2	0.0	1.3	-0.0	-0.7	-0.0	-0.4	0.2	1.1	0.7	0.1	-0.1
Sitting height	0.2	1.5	10.1	-0.9	-0.6	3.2	-0.7	-0.3	-1.6	1.0	0.2	-0.0	-1.0	1.2	-0.7	0.8
High blood pressure (mother)	0.2	0.2	1.1	0.6	-0.2	-1.0	0.0	-0.1	0.7	-0.4	0.0	-0.2	0.2	-0.7	0.0	-0.1
Body mass index (BMI)	0.2	1.0	7.2	2.7	1.1	-0.8	1.0	0.3	0.8	-0.3	0.1	-0.3	1.1	-0.6	0.7	-0.5
Impedance of leg (left)	0.2	1.1	2.6	-1.6	0.3	-0.7	0.3	-0.5	-0.9	-1.4	-1.4	-1.2	0.3	-1.2	-1.0	-1.5
Past tobacco smoking	0.2	0.4	1.2	0.7	1.1	-0.7	1.1	0.8	0.3	-0.3	-0.3	0.2	1.1	0.2	0.3	-0.6
Hearing difficulty/problems with background noise	0.2	0.3	1.8	-0.3	-0.4	1.3	-0.2	0.9	-0.0	0.7	0.3	-0.4	-0.3	0.2	0.5	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	-0.2	-0.4	0.0	-0.8	-0.7	-0.1	-0.0	0.3	0.4	-0.8	0.3	-0.4	0.6
Impedance of arm (right)	0.2	1.1	5.1	-1.9	-0.4	-2.3	0.0	-0.2	0.7	0.0	0.6	1.7	0.1	1.1	0.2	0.5
Trunk fat-free mass	0.2	1.4	12.3	-0.2	-0.7	3.5	-0.9	-0.0	-1.0	0.5	-0.2	-1.2	-1.1	-0.3	-0.5	0.1
Worrier / anxious feelings	0.2	0.4	1.3	-0.8	-1.1	0.9	-0.6	0.0	0.2	0.6	0.6	0.5	-0.6	0.4	0.0	0.9
Happiness	0.2	0.2	0.4	0.3	-0.6	0.5	-0.5	-0.2	-0.6	-0.4	-0.4	-0.6	-0.4	-0.7	-0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.7	0.8	0.4	1.3	0.1	0.3	-0.4	0.3	-0.2	-0.5	0.1	-0.0	0.0	0.0
Medication: Cholesterol lowering	0.2	0.2	1.0	0.1	0.2	0.5	0.2	0.8	0.7	0.7	0.4	-0.0	0.1	0.2	1.0	0.3
Arm fat mass (right)	0.2	0.8	4.5	2.1	1.0	-0.9	1.0	0.1	0.8	-0.3	0.2	-0.1	1.1	-0.4	0.6	-0.5
Peak expiratory flow (PEF)	0.2	0.5	1.5	0.6	1.2	0.7	1.2	1.1	0.4	0.1	-0.3	0.2	1.1	0.3	0.4	-0.7
Headache pain in last month	0.2	0.4	1.5	1.2	-0.0	-0.5	0.0	-1.1	-0.7	-0.5	-0.5	-0.5	0.1	-0.5	-0.7	-0.2
Body fat percentage	0.2	1.0	3.6	1.9	1.0	-1.9	1.1	-0.0	0.9	-0.6	0.1	-0.1	1.2	-0.6	0.5	-0.6
Arm fat-free mass (right)	0.2	1.2	10.5	0.5	-0.4	3.2	-0.7	-0.2	-1.0	0.3	-0.4	-1.3	-0.8	-0.5	-0.6	-0.1
Angina (self-reported)	0.2	0.2	0.6	0.7	0.7	0.2	0.6	0.3	-0.2	-0.1	-0.5	-0.6	0.6	-0.2	0.1	-0.8
Leg fat mass (right)	0.2	0.6	4.1	2.0	0.7	-0.5	0.6	-0.1	0.4	-0.5	-0.1	-0.6	0.7	-0.8	0.2	-0.6
Arm predicted mass (right)	0.2	1.1	9.1	0.5	-0.2	3.0	-0.5	-0.3	-1.1	0.1	-0.5	-1.3	-0.7	-0.6	-0.7	-0.3
Had major operations	0.2	0.2	1.1	1.1	0.3	-0.3	0.1	0.4	0.7	0.1	0.1	0.3	0.1	0.3	0.3	-0.3
Leg pain on walking	0.2	0.3	1.3	0.2	-0.1	1.0	-0.3	0.3	0.2	-0.2	-0.3	-0.8	-0.2	-1.1	-0.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	0.3	-0.0	-0.9	0.2	-0.6	-0.2	-0.7	-0.5	-0.3	0.4	-0.6	-0.4	-0.5
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.4	0.7	0.1	0.6	0.7	0.7	0.7	0.5	0.6	0.6	0.6	0.8	0.3
Whole body fat-free mass	0.2	0.9	8.5	0.5	-0.3	2.9	-0.6	0.0	-0.7	0.6	0.0	-0.7	-0.7	-0.0	-0.3	0.3
Arm fat percentage (left)	0.2	1.0	3.8	1.9	0.9	-1.9	1.0	0.1	1.1	-0.4	0.4	0.3	1.1	-0.3	0.7	-0.4
Arm fat-free mass (left)	0.2	1.0	6.6	0.7	-0.1	2.6	-0.2	-0.3	-1.0	-0.2	-0.8	-1.6	-0.3	-1.0	-0.7	-0.7
Heart disease (siblings)	0.2	0.2	0.7	-0.5	-0.5	-0.5	-0.4	0.1	0.8	0.2	0.6	0.8	-0.3	0.5	0.3	0.4
Arm predicted mass (left)	0.2	1.2	7.3	0.6	-0.0	2.7	-0.2	-0.4	-1.2	-0.3	-0.9	-1.8	-0.4	-1.1	-0.8	-0.8
Heel T-Score	0.1	0.7	1.6	-0.3	-0.6	-0.0	-0.8	0.7	1.2	0.8	1.2	0.8	-0.8	0.3	0.7	1.1
Waist Hip Ratio (WHR)	0.1	0.4	1.2	-0.4	0.5	-1.1	0.5	-0.4	-0.6	-0.7	-0.6	-0.8	0.6	-0.9	-0.3	-0.4
Average weekly spirits intake	0.1	0.1	0.4	-0.1	-0.5	0.1	-0.2	-0.1	-0.0	0.5	0.4	0.4	-0.2	0.6	0.2	0.4
Leg fat-free mass (left)	0.1	0.4	2.4	1.4	0.2	1.6	0.1	0.1	-0.1	0.6	0.5	0.1	0.0	0.5	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	-0.1	-0.4	-0.0	-0.2	0.9	0.9	0.2	0.2	0.3	-0.2	-0.0	0.7	0.1
Medication: Levothyroxine sodium	0.1	0.2	1.0	-0.1	-0.6	1.0	-0.5	0.3	-0.1	0.3	-0.1	-0.1	-0.5	0.1	0.0	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.4	0.0	0.3	0.0	0.0	0.1	0.1	0.4	0.2	0.1	0.2	0.2	0.5
Leg predicted mass (left)	0.1	0.4	2.5	1.3	0.1	1.6	0.1	0.1	-0.1	0.7	0.5	0.1	-0.1	0.5	0.2	0.5
Trunk fat mass	0.1	0.4	1.8	1.4	0.4	-0.8	0.5	0.0	0.8	0.0	0.6	0.4	0.5	0.0	0.5	0.1
Waist circumference	0.1	0.3	1.9	1.4	0.5	-0.1	0.4	0.2	0.4	-0.0	0.2	-0.5	0.5	-0.5	0.5	-0.1
Heart attack	0.1	0.1	0.8	-0.9	0.1	0.8	0.1	0.1	0.1	0.2	0.0	-0.2	0.1	-0.3	-0.0	-0.2
Pain all over the body in last month	0.1	0.1	0.5	0.4	0.4	-0.3	0.2	-0.0	0.2	-0.4	-0.4	-0.3	0.3	-0.4	-0.0	-0.7
Diabetes (self-reported)	0.1	0.1	0.4	0.4	-0.6	-0.0	-0.4	0.3	0.3	0.3	0.2	0.1	-0.4	0.1	0.1	0.1
Number of live births	0.1	0.2	1.0	-0.4	-0.1	1.0	0.1	0.5	-0.2	0.7	0.4	0.1	0.0	0.5	0.3	0.2
Depression (self-reported)	0.1	0.1	0.3	0.5	0.0	0.3	-0.2	0.1	0.4	0.4	0.4	0.2	-0.2	0.3	0.5	0.6
Tense / ‘highly strung’	0.1	0.2	1.0	0.5	0.1	-0.1	0.2	1.0	1.0	-0.2	0.0	0.0	0.3	-0.6	0.3	-0.3
Medication: Amlodipine	0.1	0.1	0.6	0.1	-0.2	0.2	-0.2	0.5	0.8	-0.1	-0.1	-0.1	-0.3	-0.5	0.2	-0.4
Pulse wave peak to peak time	0.1	0.1	0.4	-0.2	-0.1	0.4	0.1	0.2	-0.5	0.2	-0.2	0.1	0.1	0.6	-0.1	0.1
Medication: Blood pressure	0.1	0.2	0.7	-0.2	-0.2	-0.1	-0.3	0.5	0.8	0.7	0.6	0.5	-0.2	0.4	0.6	0.5
Whole body fat mass	0.1	0.4	2.9	1.7	0.6	-0.7	0.6	-0.0	0.5	-0.3	0.2	-0.1	0.7	-0.4	0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.5	-0.3	0.7	-0.0	0.7	0.2	0.4	-0.0	-0.1	-0.1	0.1	0.3	0.0
Smoking status: Previous	0.1	0.1	0.6	0.1	-0.3	0.1	-0.5	-0.8	-0.2	-0.3	-0.0	-0.3	-0.5	-0.4	-0.2	0.1
Leg fat-free mass (right)	0.1	0.5	3.0	1.3	0.1	1.7	0.1	0.2	-0.0	0.8	0.6	0.3	-0.0	0.8	0.3	0.6
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.0	-0.2	0.1	-0.2	-0.5	-0.7	-0.4	-0.6	-0.4	-0.2	-0.4	-0.8	-0.7
Commuting to job workplace: Walk	0.1	0.2	0.3	0.0	0.6	-0.6	0.5	0.3	0.6	-0.1	0.3	0.5	0.6	0.2	0.2	0.0
Back pain experienced in last month	0.1	0.2	0.6	0.2	0.7	0.3	0.7	-0.4	-0.8	-0.1	-0.0	-0.1	0.7	0.1	-0.3	-0.0
Whole body water mass	0.1	0.8	7.8	0.3	-0.4	2.8	-0.6	-0.1	-0.8	0.4	-0.1	-0.8	-0.8	-0.2	-0.4	0.2
Leg predicted mass (right)	0.1	0.5	2.9	1.2	0.1	1.7	0.0	0.1	-0.1	0.7	0.5	0.2	-0.1	0.7	0.2	0.5
Arm fat mass (left)	0.1	0.5	3.4	1.8	0.7	-0.7	0.7	0.0	0.6	-0.3	0.1	-0.2	0.8	-0.4	0.4	-0.4
Basal metabolic rate	0.1	0.6	5.7	0.7	-0.2	2.4	-0.3	0.0	-0.5	0.4	0.0	-0.7	-0.5	-0.1	-0.2	0.1
Pain experienced in last month	0.1	0.2	1.2	-0.5	0.2	0.8	0.1	1.1	0.5	0.4	0.0	0.0	-0.2	0.3	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	-0.8	0.2	0.9	0.2	0.5	0.4	0.5	0.2	-0.0	0.2	-0.1	0.3	-0.0
Impedance of whole body	0.1	0.6	3.1	-1.8	0.2	-1.8	0.4	-0.2	0.1	-0.4	-0.1	0.8	0.5	0.4	-0.1	-0.2
Leg fat mass (left)	0.1	0.6	3.8	2.0	0.6	-0.4	0.6	-0.2	0.2	-0.6	-0.2	-0.8	0.6	-0.9	0.0	-0.7
Weight	0.0	0.2	1.1	1.0	0.1	1.0	0.0	0.2	0.2	0.3	0.4	-0.2	-0.0	0.0	0.3	0.2
Hip circumference	0.0	0.2	0.9	1.0	0.1	0.7	0.0	0.4	0.5	0.5	0.5	-0.0	0.0	0.2	0.6	0.3
Pulse wave Arterial Stiffness index	0.0	0.1	0.3	0.1	0.0	-0.1	-0.2	-0.2	0.4	-0.1	0.1	-0.1	-0.2	-0.6	0.0	-0.1
Comparative height size at age 10	0.0	0.2	1.7	-0.3	0.5	1.3	0.5	0.5	-0.0	-0.1	-0.4	-0.3	0.4	-0.2	0.1	-0.4
Diabetes diagnosed by doctor	0.0	0.1	0.3	0.6	-0.5	-0.2	-0.2	0.3	0.2	0.1	-0.1	-0.1	-0.3	0.0	0.2	-0.3

Hub : Genes

IL1RL1

Models

Trait associations