TWAS hub - IL1R1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1380	0.0410	1.3e-06	0.094	0.071	0.077	0.092	0.100	1.5e-11	5.4e-09	1.0e-09	2.7e-11	4.0e-12
2	GTEx	Heart Atrial Appendage	0.1270	0.0580	5.8e-03	0.040	NA	0.062	NA	-0.004	6.9e-03	NA	9.8e-04	NA	5.2e-01
3	YFS	Blood	0.0635	0.0160	1.8e-12	0.018	0.037	0.042	0.037	0.040	1.1e-06	2.6e-12	1.1e-13	2.5e-12	4.0e-13
4	TCGA	Prostate Adenocarcinoma	0.3565	0.0693	0.0e+00	0.191	0.211	0.229	NA	0.228	1.4e-19	1.0e-21	1.1e-23	NA	1.4e-23
5	TCGA	Stomach Adenocarcinoma	0.0700	0.0370	8.2e-03	-0.004	0.007	-0.002	NA	-0.003	9.5e-01	9.7e-02	5.2e-01	NA	6.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Eosinophil Count	16.7	128.3	420.2	12.1	-3.4	4.3	20.5	-6.7
Allergy	14.7	33.8	96.6	-6.9	-1.0	0.7	-9.8	4.9
Allergy or Eczema	13.3	35.1	116.6	6.5	2.7	0.1	10.8	-3.0
Hayfever, allergic rhinitis or eczema	11.8	25.5	82.4	5.7	1.4	0.1	9.1	-3.3
Asthma	10.2	20.0	58.5	5.4	0.6	-0.0	7.7	-3.5
Asthma (self-reported)	9.9	19.6	57.0	5.3	0.5	-0.4	7.5	-3.5
Irritable Bowel Disease (IBD)	7.7	18.2	49.1	-5.7	7.0	0.1	2.1	2.3
Respiratory disease	7.5	16.6	58.2	4.8	-0.4	-0.2	7.6	-1.4
Ulcerative Colitis	7.2	10.5	25.2	-5.0	4.8	-1.0	1.3	1.1
Crohns Disease (2012)	6.8	11.0	35.2	-3.9	5.9	0.6	1.9	1.0
Crohns Disease (2017)	6.7	14.8	42.1	-4.2	6.5	1.6	2.0	2.8
Hayfever/allergic rhinitis (self-reported)	5.5	7.3	14.5	3.8	-0.9	-0.8	3.6	-2.8
Ulcerative Colitis (UC)	5.4	10.1	25.1	-5.0	4.6	-1.1	0.9	1.5
Wheeze or whistling in the chest in last year	5.4	9.7	26.4	3.3	-0.5	-2.2	5.1	-2.4
Ever highly irritable/argumentative for 2 days	4.7	5.6	7.7	-1.7	2.4	-2.2	2.6	-2.8
Medication: Ventolin 100micrograms inhaler	3.6	4.7	11.3	2.8	0.9	-0.0	3.4	-1.9
Number of self-reported non-cancer illnesses	3.6	6.2	13.7	1.6	0.7	-3.5	3.7	-1.4
Medication: Seretide 50 evohaler	3.2	3.7	7.9	1.8	-0.5	-1.6	2.2	-2.8
Alcohol drinker status: Never	3.1	3.7	5.6	-2.0	2.2	-2.4	1.5	-1.4
Birth weight of first child	3.0	5.5	11.6	1.9	-2.8	3.4	-2.0	-0.7
Glaucoma (self-reported)	2.9	3.4	6.5	0.8	0.8	-2.6	1.8	-2.4
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	5.4	1.4	-2.0	1.4	-2.3	1.7
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	7.3	-0.6	2.3	-1.7	2.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	14.4	-2.4	3.8	-1.5	0.0	-0.3
Illnesses of father: None of the above (group 1)	2.8	3.5	8.0	1.7	-0.2	-0.4	2.8	-2.5
Major Depression (MDD)	2.7	3.3	8.3	-1.6	0.4	-1.5	2.9	1.7
Hand grip strength (right)	2.6	7.0	18.9	4.3	-3.1	2.4	-0.8	-0.3
Taking other prescription medications	2.5	3.9	10.3	1.6	-0.6	-3.2	2.5	0.2
Eye problems/disorders: Glaucoma	2.5	3.0	6.0	0.3	0.4	-2.1	2.4	-2.1
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.1	2.5	-0.5	1.1	0.9	-1.8
Supplements: Vitamin C	2.2	2.6	4.0	-2.0	1.7	-0.7	1.4	-1.9
Diabetes (mother)	2.1	2.7	6.2	-2.5	2.5	-0.3	0.7	-0.8
Medication: Atenolol	2.1	2.7	6.8	-2.2	0.2	-1.3	-2.6	-0.1
Prostate Cancer	2.0	2.9	5.1	-1.9	1.9	-1.3	-0.1	2.3
Forced vital capacity (FVC)	2.0	7.8	13.4	3.7	-3.1	3.6	-1.1	-1.4
Alcohol intake versus 10 years previously	2.0	3.0	8.8	1.1	-2.2	-0.3	-3.0	0.5
Medication: Co-codamol	1.9	2.1	4.5	-0.4	-1.6	0.6	-2.1	1.8
Medication: Ibuprofen	1.9	2.3	8.4	-1.2	1.0	-2.9	-0.4	0.7
Ever had bowel cancer screening	1.9	2.3	6.2	-2.1	2.5	-0.3	0.3	0.7
Schizophrenia (2018)	1.8	3.7	11.9	-0.7	-1.4	1.4	-1.5	3.4
Coronary Artery Disease (CAD)	1.8	2.2	4.2	2.1	1.0	1.1	1.8	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	9.1	-0.6	0.9	-3.0	0.3	0.7
Bipolar Disorder or Schizophrenia	1.7	4.2	12.5	-1.4	-0.6	2.2	-1.1	3.5
Supplements: Zinc	1.7	1.9	6.4	-2.5	1.3	-0.0	1.0	-0.5
Breastfed as a baby	1.7	2.1	6.4	-1.6	1.1	-0.4	0.1	2.5
Shortness of breath walking on level ground	1.7	2.0	5.4	1.3	-0.3	-2.3	-0.2	-1.6
Medication: Omeprazole	1.7	2.0	8.8	0.1	0.4	-3.0	0.4	0.9
Ever had prostate specific antigen (PSA) test	1.7	2.0	6.6	-1.5	-0.7	0.7	-0.1	2.6
Schizophrenia (2014)	1.6	3.5	11.7	-2.3	0.1	0.5	-0.1	3.4
Lung FEV1/FVC ratio	1.6	8.3	18.8	-4.1	4.3	0.1	-1.8	1.6
Number of treatments/medications taken	1.6	2.8	10.3	-0.4	0.7	-3.2	1.8	-0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	4.1	0.1	1.2	-2.0	1.8	-1.1
Suffer from ‘nerves’	1.6	2.6	4.8	1.7	-2.0	2.2	-1.2	-0.1
Overall health rating	1.6	3.5	14.6	-0.6	0.9	-3.8	0.3	1.4
Chest pain or discomfort	1.6	2.3	7.4	2.7	-1.3	-0.5	1.5	-0.2
Irritability	1.6	2.6	11.2	-3.4	0.4	-1.3	-0.1	0.0
Hand grip strength (left)	1.5	3.8	7.5	2.7	-2.4	2.4	-0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.6	1.1	-1.1	-1.0	1.2	-2.1
Standing height	1.5	15.0	28.0	5.2	-5.3	3.9	-2.2	-0.3
Eye problems/disorders: None of the above	1.5	1.7	4.2	0.2	1.3	1.1	-2.1	1.1
Average weekly red wine intake	1.5	2.2	5.0	1.0	-2.0	2.2	-1.1	-0.1
Ovarian Cancer	1.4	1.8	4.6	-1.7	0.6	1.1	0.3	2.1
Bipolar Disorder (2011)	1.4	1.3	2.6	-1.6	1.1	-0.3	0.7	1.5
Height	1.4	26.7	49.1	6.0	-7.0	5.5	-4.2	0.5
High blood pressure (mother)	1.4	2.0	2.9	-1.7	1.5	-1.4	1.6	-0.5
Fluid intelligence score	1.4	3.0	8.5	-1.8	-1.8	-0.4	-2.9	0.4
Lung cancer (father)	1.4	1.6	4.4	-0.3	-0.6	-0.5	1.7	-2.1
Forced vital capacity (FVC), Best measure	1.4	5.1	10.8	2.8	-2.2	3.3	-1.0	-0.7
Health satisfaction	1.4	1.8	3.7	1.0	-1.9	-1.4	-1.1	1.0
Family relationship satisfaction	1.4	1.7	3.8	-0.9	0.0	-1.6	1.9	-1.3
Breast cancer (self-reported)	1.4	1.6	4.2	-0.4	1.6	-1.0	2.1	-0.3
Ever depressed for a whole week	1.4	1.7	4.5	1.1	-0.4	-1.1	1.2	-2.1
Blood clot in the leg (DVT)	1.3	1.7	3.4	-1.8	1.1	-1.3	-1.4	0.5
Gout (self-reported)	1.3	1.8	2.7	-1.4	-0.7	1.4	1.6	1.4
Medication: Aspirin	1.3	1.8	4.4	0.0	1.6	-2.1	0.1	-1.3
Average weekly champagne plus white wine intake	1.3	1.8	5.9	1.1	-1.0	2.4	0.9	-0.2
Illnesses of father: High blood pressure	1.3	1.6	2.4	-1.1	1.1	-1.1	-1.3	1.6
Depression (Nagel 2018)	1.2	1.8	3.6	-1.8	1.0	-0.7	-1.0	1.9
HbA1C	1.2	1.3	3.5	0.5	-1.9	1.2	1.2	0.1
Illnesses of mother	1.2	1.4	3.6	1.9	-1.1	1.4	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	6.0	1.1	0.1	2.4	0.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.9	0.4	-1.3	2.0	-1.3	0.2
Illnesses of father: Heart disease	1.2	1.7	7.4	0.0	0.6	0.7	-2.7	0.5
Smoking status: Previous	1.2	1.8	4.7	-1.2	0.2	2.2	0.9	1.4
Long-standing illness, disability or infirmity	1.2	1.9	4.2	-0.1	-0.4	-2.0	2.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.1	-0.7	0.7	-1.0	1.8	-1.4
Mother’s age at death	1.2	1.5	5.2	-0.3	-0.7	2.3	-0.6	1.2
Financial situation satisfaction	1.2	1.5	4.7	1.2	1.2	-0.3	2.2	-0.3
Cholesterol lowering medication	1.2	1.8	5.4	-1.5	2.3	-0.9	0.3	-0.4
Primary Biliary Cirrhosis	1.1	1.6	4.1	-0.8	1.7	0.3	-0.5	2.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	-0.8	-0.5	-1.8	0.4	1.3
Diabetes (father)	1.1	1.4	2.5	-1.2	0.7	-0.4	-1.6	1.5
Pack years adult smoking proportion	1.1	1.7	3.4	-1.8	1.0	-1.1	-1.5	-0.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.9	-0.2	-0.4	2.4	1.7	-0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.6	0.5	1.0	0.7	2.1	-0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	8.7	-0.6	-0.3	3.0	-0.1	0.6
Osteoporosis (self-reported)	1.1	1.4	2.5	-0.7	-0.9	1.4	-1.1	1.6
Osteoarthritis (self-reported)	1.1	1.5	3.6	1.4	0.1	0.5	-1.9	-1.3
Medication: Atorvastatin	1.1	1.4	2.9	1.1	-1.7	-1.2	-0.9	0.7
Average weekly spirits intake	1.0	1.2	3.5	-0.2	0.9	-1.9	0.5	1.2
Sitting height	1.0	7.2	17.1	3.6	-4.1	2.1	-0.9	-0.5
Father’s age at death	1.0	1.3	3.2	-1.8	1.1	-0.5	1.4	0.4
Noisy workplace	1.0	1.3	3.9	0.8	0.6	-0.5	2.0	-1.1
Trunk predicted mass	1.0	5.5	15.0	3.2	-3.9	1.4	-0.7	0.4
Emphysema/chronic bronchitis	1.0	1.1	2.2	1.4	-1.5	-0.1	-0.4	1.1
Medication: Blood pressure	1.0	1.8	6.7	-0.3	0.8	-2.6	-0.7	-1.0
Mean time to correctly identify matches	1.0	2.0	3.4	-1.2	1.8	-1.9	-1.3	-0.3
Hypertension (Self-reported)	1.0	2.6	7.5	-2.2	0.1	-2.7	-0.8	0.5
Medication for cholesterol	1.0	1.5	2.9	1.7	-1.0	0.7	1.1	-1.4
Guilty feelings	1.0	1.5	3.7	-1.9	1.0	-0.6	1.4	0.8
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.8	-0.5	-2.0	-1.0	1.2	0.0
High cholesterol (Self-reported)	1.0	1.8	5.0	-0.3	2.2	-0.8	0.1	-1.8
Vascular/heart problems diagnosed by doctor	1.0	2.8	9.3	1.8	-0.5	3.1	1.2	0.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.3	-1.5	0.9	-1.0	-1.5	0.6
Pack years of smoking	1.0	1.5	3.0	-1.7	0.8	-1.0	-1.5	-0.9
Bipolar Disorder (2018)	0.9	1.4	3.2	-1.3	0.7	1.8	0.1	1.3
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.7	-2.1	-2.2	-0.7	-2.1	0.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.4	0.9	-1.4	1.6	-0.1	0.1
Alzheimer’s Disease (including proxy)	0.9	1.3	3.9	0.8	-2.0	1.2	-0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.2	-1.6	-1.2	0.5	-2.5	-0.3
HDL Cholesterol	0.9	1.5	3.0	-0.8	1.1	-1.7	0.6	-1.5
Sensitivity / hurt feelings	0.9	1.6	5.7	-2.4	-0.2	-1.4	0.0	0.5
High blood pressure	0.9	2.6	7.7	-2.2	0.4	-2.8	-0.7	0.4
Had menopause	0.9	1.1	2.4	-1.2	1.5	0.1	0.3	1.3
Had other major operations	0.9	1.1	2.3	1.0	1.0	0.3	1.5	-1.2
Diabetes (self-reported)	0.9	1.4	3.8	-2.0	0.3	-0.9	0.7	1.3
Trunk fat-free mass	0.9	5.3	14.4	3.1	-3.8	1.4	-0.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	5.3	0.1	0.4	-2.3	-0.1	0.1
Birth weight	0.9	1.9	4.5	-1.4	-1.6	-0.2	0.4	2.1
Comparative body size at age 10	0.9	2.4	9.6	-3.1	1.3	-0.4	0.1	0.7
Number of full brothers	0.9	1.2	2.0	1.4	0.0	-1.1	1.1	1.3
Heart disease (mother)	0.9	1.1	2.4	-0.3	-0.0	-1.5	-0.8	-1.5
Diabetes diagnosed by doctor	0.9	1.5	2.9	-1.7	0.3	-1.3	0.8	1.5
Eye problems/disorders: Cataract	0.9	1.0	2.4	0.2	-1.5	0.9	0.8	-1.1
Medication: Aspirin	0.9	1.1	2.9	0.4	1.4	-1.7	-0.3	-0.7
Smoking status: Current	0.9	1.4	3.1	1.6	-1.1	-1.7	0.2	0.4
Number of operations (self-reported)	0.9	1.4	3.7	0.0	1.9	-0.6	1.4	1.0
Basal cell carcinoma (self-reported)	0.9	1.1	3.1	-0.1	-1.8	-0.9	-1.2	-0.0
Alcohol drinker status: Previous	0.9	1.0	2.9	-0.9	1.7	-0.3	0.2	1.0
Depressed Affect (Nagel 2018)	0.8	1.6	5.5	-1.1	-0.0	-0.8	0.7	2.3
Schizophrenia vs Biploar Disorder	0.8	1.0	2.5	-0.8	1.6	-1.2	-0.1	0.7
Lupus	0.8	1.2	3.8	-1.0	1.9	-0.4	0.9	-0.0
Smoking Status	0.8	1.8	6.4	0.3	-1.5	-0.4	-0.2	2.5
Lung FVC	0.8	4.0	9.1	1.9	-1.0	3.0	-1.2	-2.1
Neuroticism	0.8	1.8	4.3	-1.2	-0.1	0.8	1.7	2.1
Angina	0.8	1.0	4.1	0.6	0.4	-2.0	-0.4	-0.3
Current tobacco smoking	0.8	1.4	3.1	1.8	-1.0	-1.6	0.3	0.3
Stomach or abdominal pain in last month	0.8	0.9	2.3	0.4	-0.4	-0.4	1.5	1.4
Medication: Levothyroxine sodium	0.8	1.4	2.8	0.6	-1.4	1.7	-1.2	0.6
Chronic bronchitis/emphysema (father)	0.8	0.9	3.1	-0.8	0.7	0.4	-0.4	1.8
Hearing difficulty/problems with background noise	0.8	1.2	3.3	-1.5	-0.2	-0.4	-0.5	1.8
Hair/balding pattern: Pattern 2	0.8	1.0	1.3	0.9	-1.1	1.1	-1.0	1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.5	2.0	-1.4	2.5	-1.1	-0.7
Pulse rate	0.8	1.4	5.7	0.1	-0.1	-2.4	0.8	0.7
Pulse wave reflection index	0.8	1.0	4.4	-0.2	0.7	2.1	0.3	-0.1
Arm fat-free mass (right)	0.8	4.1	12.5	2.6	-3.5	0.8	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.5	-1.6	-0.6	-1.0	1.2	0.3
Number of children fathered	0.8	0.9	1.9	1.4	0.5	-0.4	1.2	-0.7
Qualifications: College or University degree	0.8	2.5	7.6	0.4	-2.8	0.2	-2.0	-0.9
Angina (self-reported)	0.8	1.0	3.6	1.0	0.2	-1.9	-0.5	-0.5
Medication: Allopurinol	0.8	1.1	2.2	-0.9	-0.1	0.2	1.5	1.5
Arm predicted mass (right)	0.8	4.1	12.1	2.8	-3.5	0.8	-0.2	0.5
Had major operations	0.8	0.9	4.2	-0.2	0.7	-2.0	0.2	0.1
Leg pain on walking	0.8	1.1	2.5	0.3	-1.4	-1.6	-0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.0	0.4	-1.1	-0.0	-1.7	0.3
Risk taking	0.8	1.2	1.6	0.3	1.2	-1.3	1.2	-1.1
Unable to work because of sickness or disability	0.8	1.1	3.8	-0.5	0.8	-0.4	0.7	2.0
Alzheimer’s Disease (in father)	0.7	0.8	2.3	-0.1	-1.2	-0.2	-0.4	1.5
Townsend deprivation index at recruitment	0.7	0.9	3.8	0.1	0.8	0.0	1.9	0.4
Number of incorrect matches in round	0.7	1.2	3.1	-1.5	0.3	0.7	-0.0	1.8
Past tobacco smoking	0.7	1.2	2.9	1.0	0.7	-1.2	-0.4	-1.7
Alcohol usually taken with meals	0.7	1.1	1.9	0.6	-1.4	1.2	-1.0	-0.9
Pain all over the body in last month	0.7	0.7	2.2	0.2	0.3	0.2	1.1	1.5
Happiness	0.7	0.9	1.6	-0.6	-0.8	-1.3	1.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.8	0.1	-0.1	-2.0	-0.2	0.3
Length of working week for main job	0.7	0.8	1.7	0.5	-0.8	-0.3	1.3	1.2
Exposure to tobacco smoke outside home	0.7	1.0	2.0	1.4	-0.9	-0.0	1.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	-0.0	0.1	-0.6	1.5	-1.2
Whole body fat-free mass	0.7	3.9	11.3	2.6	-3.4	1.0	-0.4	0.6
Loneliness, isolation	0.7	1.0	3.3	-1.8	0.9	-0.7	0.4	0.4
Back pain experienced in last month	0.7	1.0	2.0	0.9	-1.4	0.1	0.8	-1.3
Mineral and other dietary supplements	0.7	0.9	2.4	0.1	0.9	-1.6	-0.6	1.1
Whole body water mass	0.7	3.8	10.8	2.5	-3.3	1.0	-0.4	0.7
Ever taken oral contraceptive pill	0.7	0.8	1.1	1.1	-0.9	0.6	-0.9	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.4	1.2	1.1	-0.8	1.1	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.9	-0.2	0.4	0.2	-1.7	-0.5
Cardiovascular Disease	0.6	2.1	6.5	-1.4	-0.7	-2.5	-1.2	0.1
Hearing difficulty/problems: Yes	0.6	0.9	2.3	-1.5	0.2	-1.2	0.3	0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.9	-0.3	0.2	0.6	-1.7	0.4
Systolic blood pressure, automated reading	0.6	1.6	3.7	-0.8	1.7	0.5	-0.7	1.9
Fed-up feelings	0.6	1.1	2.5	0.1	-1.6	-0.8	-0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	-0.9	0.6	-1.3	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.2	-1.1	0.1	-1.1	-0.7	-2.0
Qualifications: CSEs or equivalent	0.6	0.8	2.4	0.6	-1.6	0.9	0.5	-0.1
Nervous feelings	0.6	1.2	3.3	-1.8	-0.2	0.6	-1.2	0.8
Financial difficulties in last 2 years	0.6	0.7	2.2	1.0	0.1	-0.7	1.5	-0.3
Mouth/teeth dental problems	0.6	0.9	2.4	0.4	-1.6	-0.7	-1.0	0.6
Medication: Simvastatin	0.6	0.8	1.7	-1.0	1.3	-1.0	-0.6	0.0
Falls in the last year	0.6	0.8	2.7	0.2	1.0	-1.6	0.4	-0.1
Medication: Cholesterol lowering	0.6	1.0	4.2	0.3	-0.0	-2.1	-0.3	-0.7
Exposure to tobacco smoke at home	0.6	0.6	2.2	0.6	-0.5	1.5	-0.7	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.8	-1.7	-0.4	-0.2	-0.3	0.4
Alcohol intake frequency.	0.6	1.4	2.4	-1.5	1.5	-1.2	0.2	1.1
Knee pain experienced in last month	0.6	1.0	3.3	-0.4	0.6	-0.8	1.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.2	1.8	-0.8	0.8	0.7	-0.9
Wears glasses or contact lenses	0.6	0.7	2.3	-0.9	-0.1	-1.5	-0.7	-0.2
Commuting to job workplace: Public transport	0.6	0.7	2.2	-0.0	-0.6	-0.9	0.3	-1.5
Arm fat-free mass (left)	0.6	3.0	7.1	2.6	-2.7	0.7	-0.1	0.5
Age started oral contraceptive pill	0.6	0.7	1.6	-0.1	0.6	1.2	-0.9	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.2	1.1	-0.3	-1.1	-0.3	-1.1
Arm predicted mass (left)	0.6	3.1	7.6	2.6	-2.8	0.8	0.0	0.6
Neuroticism (Nagel 2018)	0.5	1.1	3.3	-1.5	-0.2	0.2	0.2	1.8
Reaction Time	0.5	1.0	1.9	-0.2	1.1	-1.2	-1.4	-0.5
Fasting Glucose	0.5	0.6	1.3	-0.4	-0.6	0.7	-1.0	1.1
Blood White Count	0.5	3.9	13.5	1.9	-0.8	-1.3	3.7	0.5
BMI	0.5	2.7	4.3	-1.9	2.1	-2.0	0.7	1.0
Systolic Blood Pressure	0.5	2.3	5.1	-0.9	2.2	0.2	-2.2	0.8
Chronotype (morning person)	0.5	1.2	2.6	0.2	1.2	-1.6	1.4	-0.2
Average weekly fortified wine intake	0.5	0.6	1.8	-0.1	1.4	-0.7	0.7	-0.3
Supplements: Glucosamine	0.5	0.7	2.1	-1.4	0.0	-0.7	0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	0.5	0.7	-0.6	1.2	0.8
Heart attack	0.5	0.6	1.2	1.1	-0.3	-0.9	-0.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.9	0.3	0.2	-1.4	1.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.1	1.0	-0.6	2.5	-0.8	-0.4
Tense / ‘highly strung’	0.5	0.8	2.2	-0.5	0.3	-1.0	1.5	-0.7
Hair/balding pattern: Pattern 4	0.5	1.1	2.4	-1.1	0.8	-1.6	-0.0	-1.2
Medication: Paracetamol	0.5	0.8	1.5	0.9	-1.2	-0.4	1.0	-0.7
Worry too long after embarrassment	0.5	0.8	1.3	-1.0	-0.5	1.1	0.3	1.1
Migraine (self-reported)	0.5	0.6	2.3	-0.5	-0.6	-1.5	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.3	1.4	-0.6	0.6	-0.1
Pulse rate, automated reading	0.5	1.7	2.8	1.6	-0.8	-1.5	1.7	0.4
Comparative height size at age 10	0.5	2.6	9.8	3.1	-1.0	1.2	-1.0	-0.1
Age at last live birth	0.5	0.7	1.8	-0.9	-1.3	0.6	0.9	0.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.8	1.4	-0.4	0.3	0.7	-0.2
Medication: Blood pressure	0.5	0.9	3.4	-1.9	0.7	0.0	-0.6	0.4
Medication: Bendroflumethiazide	0.5	0.8	1.6	-0.5	1.2	0.8	-1.3	-0.3
Medication: Paracetamol	0.5	0.8	1.7	0.7	-1.3	-0.9	0.2	-0.9
Basal metabolic rate	0.5	3.0	8.0	2.4	-2.8	0.9	-0.3	0.7
Diastolic blood pressure, automated reading	0.5	1.5	4.4	-0.3	1.8	-0.3	-0.2	2.1
Worry (Nagel 2018)	0.4	0.7	3.2	0.6	-0.2	1.8	0.2	-0.3
Mean Putamen Volume	0.4	0.4	0.9	-0.4	0.3	-0.9	0.5	-0.9
Neuroticism (2016)	0.4	0.5	0.9	-1.0	0.1	-0.7	0.9	0.7
Rheumatoid Arthritis	0.4	0.5	1.1	-0.2	-0.3	0.9	1.1	0.6
Blood Platelet Count	0.4	4.4	11.6	-0.5	0.5	-1.1	3.0	3.4
Tanning	0.4	4.5	14.4	2.3	-3.8	0.9	-1.2	-0.9
Medication for hormone replacement therapy	0.4	0.4	0.7	0.8	-0.7	0.2	-0.6	0.7
Medication: Metformin	0.4	0.6	2.2	-0.3	-0.1	-0.8	0.4	1.5
Maternal smoking around birth	0.4	0.6	1.3	-0.3	-1.1	-0.9	0.2	1.0
Multivitamins +/- minerals	0.4	0.5	1.6	0.7	-1.3	0.1	-0.2	0.3
Qualifications: None of the above	0.4	0.9	1.9	-0.2	1.2	0.9	-0.4	1.4
Arm fat percentage (right)	0.4	1.4	4.1	-0.7	2.0	-0.3	1.2	1.0
Worrier / anxious feelings	0.4	0.7	2.2	-0.1	-0.8	1.5	0.7	0.2
Number of live births	0.4	0.6	1.0	0.6	-0.9	1.0	-0.9	0.4
Peak expiratory flow (PEF)	0.4	0.9	3.1	1.7	-0.6	0.8	0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	0.5	-1.3	0.3	-0.9	-0.8
Medication: Amlodipine	0.4	0.5	1.7	0.3	-0.3	-1.3	0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	0.5	0.9	-0.8	-0.4	0.9
Leg fat percentage (right)	0.4	1.4	3.0	-0.1	1.7	-0.8	1.7	0.6
Pulse wave peak to peak time	0.4	0.5	1.5	1.2	-0.6	0.4	0.4	-0.2
Leg fat-free mass (right)	0.4	2.2	6.2	1.8	-2.5	0.7	-0.4	0.9
Mood swings	0.4	0.7	2.0	-0.4	-0.9	-1.4	0.4	0.5
Qualifications: nursing, teaching	0.4	0.6	1.0	0.8	-0.8	-1.0	0.5	-0.3
Leg predicted mass (right)	0.4	2.2	6.3	1.8	-2.5	0.7	-0.3	0.9
Hearing aid user	0.4	0.5	1.2	-0.1	-1.1	-0.9	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.8	-0.4	-0.9	0.7	0.9	-0.8
Ever smoked	0.4	0.7	1.3	-0.1	-1.1	0.8	0.7	1.1
Heart disease (siblings)	0.4	0.5	2.3	-0.2	1.5	-0.1	-0.5	0.1
Age at First Birth	0.3	0.4	1.3	0.2	-0.1	-0.8	1.1	-0.4
LDL Cholesterol	0.3	0.4	1.0	0.7	0.4	0.4	-0.6	-1.0
Triglycerides	0.3	0.5	1.2	0.6	1.1	0.8	-0.6	-0.5
Leg fat-free mass (left)	0.3	1.7	4.8	1.7	-2.2	0.5	-0.2	0.5
Trunk fat percentage	0.3	1.0	2.7	-0.5	1.6	0.1	1.0	1.1
Serious illness, injury or assault to yourself	0.3	0.4	0.9	0.0	0.9	-1.0	0.0	-0.3
Body mass index (BMI)	0.3	1.3	1.6	-1.0	1.3	-1.0	1.1	1.3
Leg predicted mass (left)	0.3	1.9	5.1	1.8	-2.2	0.6	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.4	-0.1	-0.3	-0.5	-0.8	-1.6
Illnesses of siblings	0.3	0.5	1.1	0.3	-1.1	-0.1	1.0	0.4
Hip circumference	0.3	1.3	3.4	0.5	-0.9	1.1	0.8	1.9
Time employed in main current job	0.3	0.3	1.4	0.1	1.2	-0.5	-0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.3	-0.1	-1.5	-0.0	-0.9	-0.4
Prospective memory result	0.3	0.4	0.9	-0.1	0.1	0.9	0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-0.8	-1.0	-0.8	0.3	0.1
High blood pressure (siblings)	0.3	0.4	0.7	0.1	0.8	-0.3	-0.8	-0.9
Body fat percentage	0.3	1.2	3.0	-0.3	1.7	-0.4	1.4	1.0
Neck or shoulder pain in last month	0.3	0.5	1.8	-0.6	0.2	-0.3	1.4	0.3
Arm fat percentage (left)	0.3	1.1	2.0	-0.4	1.4	-0.1	1.2	1.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.5	1.0	0.2	0.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	0.7	-0.8	0.3	-0.8	-0.3
Friendships satisfaction	0.3	0.4	1.4	0.2	-0.5	-1.2	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.8	-0.9	0.6	-0.9	-0.9	0.0
Leg fat percentage (left)	0.3	1.3	2.6	-0.2	1.6	-0.6	1.5	1.0
Supplements: Calcium	0.3	0.4	1.3	-0.2	0.7	0.3	1.1	-0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.5	0.7	0.4	-0.5	-0.4
Waist Hip Ratio (WHR)	0.2	0.8	2.1	1.4	1.0	-0.4	-0.4	-0.6
Hypothyroidism (self reported)	0.2	0.5	0.7	0.8	0.8	0.6	-0.5	0.7
Hair Pigment	0.2	6.5	16.0	-0.6	2.9	-4.0	2.6	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.4	0.6	-0.5	-0.1	-0.6
Relative age of first facial hair	0.2	0.5	1.3	-1.1	0.4	0.8	0.4	-0.5
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	0.2	0.3	-0.3	0.3	1.0
Vitamin and mineral supplements	0.2	0.3	0.5	-0.6	0.6	0.1	-0.2	0.7
Impedance of leg (right)	0.2	1.0	2.2	1.1	0.9	0.7	0.6	-1.5
Age when periods started (menarche)	0.2	0.5	0.9	1.0	0.1	0.7	0.5	0.8
Impedance of leg (left)	0.2	0.9	1.3	1.0	0.8	1.1	0.6	-1.1
Medication: Ramipril	0.2	0.2	0.6	-0.8	0.4	-0.1	-0.5	0.2
Neuroticism score	0.2	0.5	0.8	-0.9	-0.5	-0.0	0.9	0.8
Weight	0.2	1.1	1.8	1.4	-1.3	0.8	0.1	1.1
Impedance of arm (right)	0.2	1.0	2.3	-0.5	1.5	1.2	-0.3	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.5	-0.7	0.5	-0.8	-0.3
Depression (self-reported)	0.2	0.2	0.6	-0.2	0.5	-0.8	0.5	0.2
Pulse wave Arterial Stiffness index	0.2	0.3	1.0	-1.0	0.4	-0.1	-0.4	0.2
Impedance of arm (left)	0.2	0.7	2.5	-0.0	0.7	1.6	-0.4	-0.6
Loud music exposure frequency	0.2	0.2	0.8	-0.3	0.1	0.9	0.3	-0.2
Headache pain in last month	0.2	0.3	1.1	1.1	0.5	-0.1	-0.0	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.5	-0.2	0.8	-1.0	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.7	-0.1	-0.2	-0.8	0.1
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.4	-0.3	-0.6	0.4	-0.4
Medication: Gliclazide	0.2	0.2	0.5	0.5	0.3	-0.5	0.3	-0.7
Miserableness	0.2	0.3	1.0	0.1	-0.7	-1.0	-0.3	0.3
Medication: Lisinopril	0.2	0.3	1.1	0.1	0.1	0.3	0.3	-1.0
Average weekly beer plus cider intake	0.2	0.3	0.9	0.4	0.5	0.2	0.9	-0.0
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.2	-0.8	0.6	-0.1	0.1
Myopia	0.2	0.3	0.7	0.6	-0.5	-0.8	-0.1	0.0
Pain experienced in last month	0.2	0.3	1.3	-1.1	0.3	0.1	-0.4	-0.1
Impedance of whole body	0.2	1.0	2.0	0.6	1.0	1.4	-0.1	-1.3
Breast Cancer	0.1	0.2	0.3	-0.3	-0.2	-0.3	-0.6	-0.5
Heel T-Score	0.1	1.2	2.5	-1.2	0.7	-1.2	0.0	-1.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.5	-0.7	-0.4	-0.2	-0.0	-0.1
Severe depression (siblings)	0.1	0.1	0.5	-0.2	0.7	0.0	-0.0	0.2
Relative age voice broke	0.1	0.2	0.8	-0.9	0.2	0.4	-0.3	0.0
Trunk fat mass	0.1	0.5	1.2	0.4	0.5	0.3	0.8	1.1
Waist circumference	0.1	0.4	0.8	0.3	0.6	-0.6	0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	-0.2	0.3	-0.2	0.9	0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	-0.1	-0.2	-0.3	0.7	-0.4
Arm fat mass (right)	0.1	0.5	1.0	-0.0	1.0	-0.1	0.9	0.9
Age at first live birth	0.1	0.3	0.6	-0.8	-0.7	0.2	0.3	0.4
Whole body fat mass	0.1	0.5	1.0	0.5	0.3	-0.1	1.0	1.0
Leg fat mass (right)	0.1	0.5	1.4	0.3	0.6	-0.6	1.2	0.5
Arm fat mass (left)	0.1	0.5	1.1	0.2	0.5	0.0	1.0	1.1
Leg fat mass (left)	0.1	0.5	1.5	0.3	0.5	-0.5	1.2	0.8
Blood Red Count	0.0	0.3	1.5	0.2	1.2	-0.1	-0.2	0.4
Medication: Lansoprazole	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.2	0.4
Number of full sisters	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.1	0.3

Hub : Genes

IL1R1

Models

Trait associations