[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr5:149,577,574-151,236,214

Best TWAS P=1.32e-21 · Best GWAS P=2.14e-20 conditioned to 0.0394

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCTN4	0.18	0.03	blup	51	0.03	1.8e-04	8.6	9.6	1.3e-21	0.86	0.00	0.99	TRUE
58	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF300	0.03	0.01	blup	45	0.01	8.1e-02	8.6	9.3	1.7e-20	0.89	0.02	0.40	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF300	0.05	0.04	lasso	2	0.03	9.3e-05	9.0	9.2	2.2e-20	0.98	0.02	0.97	FALSE
56	The Cancer Genome Atlas	Soft Tissue Sarcoma	IRGM	0.08	0.05	lasso	8	0.05	5.3e-04	9.1	9.2	5.7e-20	0.99	0.01	0.94	FALSE
40	GTEx	Vagina	ZNF300P1	0.61	0.17	lasso	11	0.27	6.2e-07	8.1	9.1	9.1e-20	0.93	0.04	0.95	FALSE
28	GTEx	Muscle Skeletal	ZNF300P1	0.49	0.41	enet	20	0.51	2.9e-58	9.0	9.1	1.0e-19	0.95	0.04	0.96	FALSE
39	GTEx	Thyroid	ZNF300P1	0.57	0.58	lasso	9	0.60	7.8e-57	9.0	9.1	1.3e-19	0.97	0.04	0.96	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IRGM	0.17	0.09	lasso	4	0.08	1.2e-09	9.1	9.1	1.3e-19	0.99	0.02	0.98	FALSE
37	GTEx	Stomach	ZNF300P1	0.57	0.41	enet	31	0.48	7.4e-26	8.1	9.0	1.6e-19	0.88	0.29	0.71	FALSE
5	GTEx	Artery Coronary	ZNF300P1	0.73	0.71	lasso	3	0.70	5.9e-32	9.0	9.0	1.7e-19	0.99	0.04	0.96	FALSE
32	GTEx	Pancreas	ZNF300P1	0.58	0.60	lasso	4	0.60	7.6e-31	9.0	8.9	3.8e-19	0.98	0.04	0.96	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LOC134466	0.12	0.09	lasso	5	0.08	2.0e-04	9.1	8.9	6.0e-19	0.98	0.00	0.98	FALSE
31	GTEx	Ovary	ZNF300P1	0.36	0.12	lasso	5	0.11	1.2e-03	8.2	8.9	8.1e-19	0.95	0.04	0.89	FALSE
6	GTEx	Artery Tibial	ZNF300P1	0.66	0.65	enet	14	0.69	1.5e-74	9.0	8.8	9.0e-19	0.96	0.04	0.96	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ZNF300P1	0.72	0.55	lasso	8	0.52	9.1e-16	9.0	8.8	1.2e-18	0.97	0.04	0.96	FALSE
14	GTEx	Breast Mammary Tissue	ZNF300P1	0.49	0.39	enet	20	0.47	7.7e-27	8.1	8.8	1.3e-18	0.93	0.16	0.84	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ZNF300P1	0.44	0.44	lasso	3	0.46	1.3e-41	9.0	8.8	1.3e-18	0.97	0.04	0.96	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ZNF300P1	0.66	0.33	enet	22	0.44	1.1e-14	9.0	8.8	1.4e-18	0.90	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC134466	0.43	0.04	enet	15	0.08	7.2e-04	9.0	8.8	1.5e-18	0.91	0.01	0.95	FALSE
3	GTEx	Adipose Visceral Omentum	ZNF300P1	0.67	0.43	enet	12	0.54	5.2e-33	9.0	8.8	2.0e-18	0.93	0.04	0.96	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	ZNF300P1	0.74	0.64	lasso	4	0.69	2.7e-33	9.0	8.8	2.1e-18	0.95	0.08	0.92	FALSE
23	GTEx	Esophagus Muscularis	ZNF300P1	0.61	0.61	enet	17	0.62	9.7e-48	8.1	8.7	3.1e-18	0.93	0.22	0.78	FALSE
27	GTEx	Lung	ZNF300P1	0.57	0.46	lasso	8	0.58	8.1e-54	8.1	8.7	3.4e-18	0.94	0.15	0.85	FALSE
2	GTEx	Adipose Subcutaneous	ZNF300P1	0.64	0.54	lasso	9	0.63	5.3e-66	8.1	8.7	3.6e-18	0.94	0.14	0.86	FALSE
30	GTEx	Nerve Tibial	ZNF300P1	0.70	0.63	lasso	4	0.70	5.8e-68	8.1	8.6	6.2e-18	0.93	0.62	0.38	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC134466	0.13	0.09	lasso	4	0.09	8.0e-08	8.2	8.6	1.2e-17	0.91	0.04	0.96	FALSE
25	GTEx	Heart Left Ventricle	ZNF300P1	0.53	0.47	enet	20	0.51	3.3e-31	8.1	8.5	1.5e-17	0.89	0.16	0.84	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ZNF300P1	0.53	0.49	lasso	5	0.50	7.4e-31	8.1	8.5	2.2e-17	0.91	0.67	0.33	FALSE
4	GTEx	Adrenal Gland	ZNF300P1	0.53	0.15	enet	16	0.14	1.0e-05	9.0	8.4	3.4e-17	0.92	0.02	0.97	FALSE
33	GTEx	Pituitary	ZNF300P1	0.72	0.41	lasso	14	0.46	4.1e-13	8.2	8.4	3.9e-17	0.90	0.06	0.94	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCTN4	0.10	0.02	enet	11	0.03	1.9e-07	8.6	8.4	4.2e-17	0.83	0.00	1.00	FALSE
38	GTEx	Testis	ZNF300	0.28	0.18	lasso	6	0.18	2.1e-08	9.0	8.4	5.6e-17	0.96	0.02	0.98	FALSE
19	GTEx	Colon Transverse	ZNF300P1	0.51	0.41	enet	8	0.47	9.2e-25	8.1	8.3	6.9e-17	0.89	0.62	0.38	FALSE
26	GTEx	Liver	ZNF300P1	0.32	0.18	lasso	4	0.15	7.3e-05	8.1	8.3	7.6e-17	0.88	0.09	0.90	FALSE
24	GTEx	Heart Atrial Appendage	ZNF300P1	0.61	0.39	enet	19	0.47	2.0e-23	9.0	8.2	2.0e-16	0.93	0.06	0.94	FALSE
36	GTEx	Spleen	ZNF300P1	0.69	0.50	lasso	7	0.47	9.8e-14	8.1	8.2	2.0e-16	0.88	0.15	0.85	FALSE
21	GTEx	Esophagus Mucosa	ZNF300P1	0.55	0.44	enet	20	0.50	4.0e-38	8.1	8.1	3.8e-16	0.88	0.58	0.42	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ZNF300P1	0.36	0.24	lasso	3	0.21	1.1e-05	8.1	8.1	4.4e-16	0.85	0.08	0.82	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC134466	0.10	0.05	enet	7	0.05	2.1e-06	9.0	8.1	7.9e-16	0.89	0.01	0.99	FALSE
18	GTEx	Colon Sigmoid	ZNF300P1	0.65	0.34	enet	24	0.50	3.4e-20	8.1	8.0	1.4e-15	0.81	0.37	0.63	FALSE
13	GTEx	Brain Putamen basal ganglia	ZNF300P1	0.44	0.28	lasso	4	0.34	4.9e-09	8.1	7.6	3.1e-14	0.84	0.05	0.94	FALSE
22	GTEx	Esophagus Muscularis	ZNF300	0.10	0.10	enet	12	0.10	9.6e-07	9.1	7.5	6.3e-14	0.90	0.02	0.97	FALSE
10	GTEx	Brain Frontal Cortex BA9	ZNF300P1	0.34	0.15	enet	22	0.32	4.4e-09	9.0	7.3	3.8e-13	0.80	0.03	0.94	FALSE
55	The Cancer Genome Atlas	Rectum Adenocarcinoma	DCTN4	0.83	-0.01	lasso	16	0.08	6.8e-03	8.4	7.1	1.2e-12	0.63	0.00	0.43	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZNF300P1	0.36	0.18	lasso	6	0.36	9.5e-46	9.0	6.8	7.9e-12	0.77	0.04	0.96	FALSE
11	GTEx	Brain Hypothalamus	ZNF300P1	0.68	0.24	lasso	16	0.35	4.1e-09	9.0	6.7	1.7e-11	0.80	0.04	0.93	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ZNF300P1	0.36	0.31	bslmm	516	0.48	2.8e-69	9.0	6.7	2.5e-11	0.81	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC134466	0.05	0.00	blup	46	0.01	1.1e-02	-1.4	6.6	5.0e-11	0.69	0.02	0.62	FALSE
7	GTEx	Brain Caudate basal ganglia	ZNF300P1	0.60	0.17	lasso	8	0.35	7.7e-11	9.0	6.5	5.9e-11	0.77	0.04	0.95	FALSE
9	GTEx	Brain Cortex	ZNF300P1	0.41	0.15	lasso	4	0.31	2.7e-09	8.2	6.5	6.6e-11	0.71	0.10	0.75	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	ZNF300P1	0.35	0.16	enet	11	0.18	1.3e-05	9.0	6.1	1.3e-09	0.67	0.04	0.91	FALSE
41	NTR	Blood	ANXA6	0.10	0.02	enet	31	0.05	2.1e-15	2.6	6.0	1.8e-09	0.30	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	ZNF300P1	0.35	0.26	lasso	7	0.38	2.3e-30	-1.4	5.9	3.9e-09	0.65	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	ZNF300	0.13	0.05	lasso	4	0.09	7.0e-07	-1.6	5.6	2.6e-08	0.60	0.20	0.61	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC134466	0.22	0.04	lasso	5	0.11	7.2e-07	-1.4	5.5	4.0e-08	0.63	0.32	0.60	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC134466	0.09	0.06	lasso	4	0.07	1.7e-08	-1.4	5.4	7.8e-08	0.59	0.28	0.70	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC134466	0.13	0.09	lasso	4	0.11	1.8e-12	-1.6	5.4	7.8e-08	0.58	0.86	0.14	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC134466	0.17	0.04	enet	8	0.08	1.7e-08	-1.6	5.4	8.0e-08	0.64	0.49	0.50	FALSE