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chr11:46,010,847-48,559,571

Best TWAS P=1.85e-15 · Best GWAS P=6e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	7.5	-8.0	1.9e-15	-0.89	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	-6.2	-6.8	1.5e-11	-0.34	0.84	0.15	TRUE
18	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-3.8	6.4	2.1e-10	0.58	0.34	0.41	TRUE
30	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-6.2	6.2	7.4e-10	0.46	0.88	0.08	TRUE
3	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	-6.5	6.1	9.2e-10	0.39	0.08	0.91	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-6.4	-5.6	2.1e-08	-0.24	0.00	0.76	TRUE
22	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	-5.4	5.5	4.2e-08	0.43	0.75	0.19	TRUE
21	GTEx	Ovary	ARHGAP1	0.25	0.09	lasso	16	0.18	3.8e-05	-3.4	5.3	8.8e-08	0.31	0.20	0.35	TRUE
6	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-4.9	7.7	1.2e-14	0.49	0.12	0.66	FALSE
35	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	6.2	-7.3	3.4e-13	-0.85	0.02	0.98	FALSE
15	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-6.2	-7.2	5.1e-13	-0.57	0.32	0.44	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	4.1	-7.2	5.3e-13	-0.60	0.04	0.85	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.4	-7.0	2.6e-12	-0.51	0.01	0.91	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-6.0	-6.5	5.8e-11	-0.36	0.01	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	6.4	-6.4	2.0e-10	-0.70	0.28	0.39	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	6.4	-6.3	2.3e-10	-0.56	0.02	0.82	FALSE
5	GTEx	Artery Tibial	LRP4	0.06	0.00	lasso	5	0.00	6.4e-01	5.8	6.3	2.6e-10	0.32	0.06	0.08	FALSE
27	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	-5.6	-6.3	3.0e-10	-0.36	0.92	0.08	FALSE
34	METSIM	Adipose	DDB2	0.03	0.03	lasso	2	0.02	1.9e-04	-6.0	6.3	3.5e-10	0.25	0.70	0.17	FALSE
24	GTEx	Prostate	CELF1	0.17	0.16	lasso	2	0.12	6.2e-04	-6.3	-6.3	3.6e-10	-0.29	0.18	0.07	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.2	-6.2	4.5e-10	-0.37	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.2	6.2	4.5e-10	0.37	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-6.2	6.2	5.2e-10	0.37	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.2	6.2	5.4e-10	0.36	0.00	1.00	FALSE
31	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	5.1	6.2	7.1e-10	0.54	0.81	0.04	FALSE
36	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-6.2	6.2	7.7e-10	0.37	0.89	0.11	FALSE
9	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	5.1	6.1	9.9e-10	0.56	0.05	0.05	FALSE
33	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.2	6.1	1.2e-09	0.34	0.88	0.12	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP1	0.06	0.01	lasso	9	0.00	2.8e-01	-6.2	6.1	1.3e-09	0.32	0.08	0.55	FALSE
32	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-6.1	6.1	1.4e-09	0.35	0.59	0.08	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.2	-6.0	2.0e-09	-0.37	0.89	0.11	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	4.5	-6.0	2.5e-09	-0.31	0.03	0.09	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	DDB2	0.04	0.03	enet	15	0.03	7.1e-05	-6.3	5.9	3.1e-09	0.20	0.80	0.15	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	5.2	-5.9	3.9e-09	-0.63	0.94	0.05	FALSE
16	GTEx	Esophagus Muscularis	CKAP5	0.05	0.03	lasso	4	0.04	3.3e-03	-5.5	-5.9	4.2e-09	-0.26	0.41	0.07	FALSE
25	GTEx	Prostate	ZNF408	0.19	0.10	lasso	2	0.10	1.6e-03	-6.2	5.9	4.4e-09	0.28	0.06	0.58	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-6.3	-5.9	4.8e-09	-0.35	0.01	0.96	FALSE
8	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-6.2	-5.8	6.4e-09	-0.28	0.39	0.09	FALSE
11	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	5.0	-5.7	1.0e-08	-0.48	0.98	0.01	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-6.2	5.7	1.2e-08	0.36	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-6.2	5.7	1.4e-08	0.35	0.00	0.92	FALSE
10	GTEx	Breast Mammary Tissue	ARHGAP1	0.05	0.00	enet	14	0.01	1.3e-01	-4.9	5.7	1.5e-08	0.44	0.11	0.26	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-4.7	5.6	2.0e-08	0.46	0.19	0.18	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	3.3	-5.6	2.1e-08	-0.27	0.14	0.07	FALSE
17	GTEx	Esophagus Muscularis	ARHGAP1	0.07	0.08	lasso	3	0.07	6.1e-05	-5.5	5.6	2.5e-08	0.26	0.37	0.57	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	-5.1	-5.5	2.9e-08	-0.35	0.87	0.06	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	-3.7	-5.5	3.3e-08	-0.35	0.95	0.05	FALSE
4	GTEx	Artery Aorta	CKAP5	0.09	0.12	lasso	1	0.07	1.2e-04	-5.5	-5.5	4.0e-08	-0.23	0.93	0.02	FALSE
29	GTEx	Skin Sun Exposed Lower leg	ARHGAP1	0.08	0.01	lasso	5	0.02	1.4e-02	-4.9	5.5	4.1e-08	0.35	0.21	0.28	FALSE
28	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-3.8	5.5	4.2e-08	0.47	0.97	0.03	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.2	5.5	5.1e-08	0.35	0.00	1.00	FALSE
20	GTEx	Nerve Tibial	CELF1	0.08	0.02	enet	15	0.06	4.3e-05	6.0	-5.3	8.8e-08	-0.70	0.06	0.75	FALSE
14	GTEx	Esophagus Mucosa	ARFGAP2	0.05	0.06	lasso	4	0.05	4.4e-04	-5.4	-5.3	9.3e-08	-0.37	0.32	0.05	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ZNF408	0.04	0.02	blup	243	0.03	5.0e-05	-5.6	5.3	1.2e-07	0.18	0.21	0.77	FALSE
12	GTEx	Cells Transformed fibroblasts	PACSIN3	0.07	0.00	enet	7	0.01	1.2e-01	-6.3	5.1	2.8e-07	0.17	0.11	0.10	FALSE
19	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-4.7	5.1	2.9e-07	0.36	0.94	0.06	FALSE