TWAS hub - F12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Liver Hepatocellular Carcinoma	0.1590	0.0710	0.0011	0.064	0.010	0.114	NA	0.111	6.0e-04	0.1100	5.2e-06	NA	7.0e-06
2	TCGA	Prostate Adenocarcinoma	0.0544	0.0274	0.0017	0.033	0.017	0.030	NA	0.022	1.9e-04	0.0054	4.0e-04	NA	2.0e-03
3	TCGA	Skin Cutaneous Melanoma	0.1480	0.0860	0.0040	0.193	0.103	0.083	NA	0.185	7.0e-06	0.0011	3.2e-03	NA	1.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Forced vital capacity (FVC), Best measure	6.1	22.3	33.0	-5.1	5.7	2.8
Pulse wave peak to peak time	5.9	7.0	8.1	-2.8	2.8	2.2
Pulse wave reflection index	5.8	7.2	11.5	3.4	-3.1	-0.6
Blood Red Count	5.6	54.5	96.8	5.8	-5.8	-9.8
Medication: Aspirin	5.6	7.4	9.9	2.0	-2.9	-3.1
Medication: Aspirin	5.5	7.3	9.7	2.0	-2.9	-3.1
Forced vital capacity (FVC)	5.4	20.9	31.9	-5.0	5.6	2.3
Height	5.3	101.6	135.7	-11.6	10.7	7.4
Mouth/teeth dental problems: Loose teeth	5.2	6.2	12.3	1.0	-2.3	-3.5
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.6	22.1	-3.6	4.7	3.4
Number of self-reported non-cancer illnesses	4.9	8.6	11.3	2.6	-3.4	-2.8
Comparative height size at age 10	4.8	26.3	37.2	-6.1	5.1	4.0
Standing height	4.7	46.4	55.5	-7.4	7.1	5.7
Birth weight of first child	4.5	8.1	13.8	-1.8	3.7	2.7
Eye problems/disorders: None of the above	4.5	5.2	8.9	3.0	-2.1	-1.5
Cardiovascular Disease	4.3	14.2	25.3	3.5	-5.0	-2.3
Triglycerides	4.1	6.8	9.4	3.1	-3.0	-1.3
Hand grip strength (left)	4.1	10.7	16.0	-3.2	4.0	2.5
Type 2 Diabetes (T2D) (2018)	4.0	7.4	13.6	1.7	-2.4	-3.7
Birth weight	4.0	8.7	12.1	-2.4	3.5	2.8
Hypertension (Self-reported)	4.0	11.0	19.8	2.9	-4.5	-2.2
Medication for cholesterol	4.0	6.0	10.0	-2.3	3.2	1.7
Medication: Blood pressure	4.0	7.6	14.1	2.3	-3.8	-1.9
Medication: Simvastatin	3.9	5.8	7.1	2.3	-2.7	-2.2
Pulse wave Arterial Stiffness index	3.9	4.5	5.5	2.4	-2.2	-1.8
Medication for cholesterol, blood pressure or diabetes	3.8	6.2	11.3	-2.1	3.4	1.8
Father’s age at death	3.7	4.9	6.8	2.6	-2.1	-1.9
Exposure to tobacco smoke at home	3.7	4.2	8.5	1.7	-2.9	-1.1
High cholesterol (Self-reported)	3.7	6.6	11.9	2.4	-3.5	-1.5
Medication: Ramipril	3.5	4.4	5.5	1.6	-2.3	-2.3
Asthma (self-reported)	3.5	7.0	19.5	0.4	-1.1	-4.4
Allergy or Eczema	3.4	8.9	23.1	1.4	-1.2	-4.8
Respiratory disease	3.4	7.6	22.3	0.2	-0.8	-4.7
High blood pressure	3.4	9.5	16.3	2.7	-4.0	-2.3
Forced expiratory volume in 1-second (FEV1)	3.4	11.5	18.9	-3.1	4.3	2.5
Number of treatments/medications taken	3.3	5.9	9.0	1.4	-2.6	-3.0
Glaucoma (self-reported)	3.3	3.8	6.4	-2.2	2.5	0.5
Commuting to job workplace: Public transport	3.3	3.9	6.0	2.5	-0.7	-2.3
Diabetes (father)	3.2	3.9	6.4	2.5	-1.3	-1.9
Supplements: Vitamin C	3.2	3.8	4.4	1.9	-2.1	-1.8
Ulcerative Colitis (UC)	3.1	5.7	15.1	-1.3	0.7	-3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.0	-2.5	3.0	2.0
Eye problems/disorders: Glaucoma	3.1	3.7	5.8	-2.4	2.1	0.9
Blood Eosinophil Count	3.0	23.3	67.1	1.5	-0.8	-8.2
Age at first live birth	3.0	5.3	8.6	-2.7	2.9	0.0
Vascular/heart problems diagnosed by doctor	3.0	8.2	14.0	-2.2	3.7	2.4
Taking other prescription medications	2.9	4.5	13.1	0.5	-0.3	-3.6
Asthma	2.9	5.7	16.3	0.3	-0.9	-4.0
Diabetes diagnosed by doctor	2.9	4.7	9.7	1.0	-1.9	-3.1
Irritable Bowel Disease (IBD)	2.8	6.6	17.0	-1.5	0.7	-4.1
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.9	8.1	-2.6	2.8	1.6
Medication: Cholesterol lowering	2.7	4.3	6.0	2.1	-2.5	-1.6
Trunk predicted mass	2.7	15.1	18.9	-4.3	4.2	3.0
Trunk fat-free mass	2.6	15.0	18.5	-4.3	4.2	3.0
Length of working week for main job	2.6	2.9	3.4	1.6	-1.9	-1.6
Diastolic blood pressure, automated reading	2.6	8.0	12.0	3.5	-3.4	-0.6
Diabetes (self-reported)	2.5	3.8	7.6	0.7	-1.9	-2.8
Hand grip strength (right)	2.4	6.5	10.7	-2.4	3.3	1.7
Alcohol usually taken with meals	2.4	3.9	5.8	1.8	-1.7	-2.4
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	4.2	1.8	-1.5	-2.1
Hayfever, allergic rhinitis or eczema	2.3	4.9	13.8	0.8	-0.6	-3.7
Allergy	2.3	5.3	14.1	-0.5	1.2	3.8
Health satisfaction	2.3	2.9	5.4	-2.3	1.8	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	5.1	-1.8	2.3	0.1
Osteoporosis (self-reported)	2.3	2.8	5.5	-1.3	1.1	2.3
Alzheimer’s Disease (in father)	2.2	2.3	4.2	-1.0	1.4	2.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	8.2	0.4	-0.2	-2.9
Medication: Ventolin 100micrograms inhaler	2.2	2.9	7.7	-0.7	-0.7	-2.8
Arm fat-free mass (right)	2.2	11.4	17.1	-4.1	3.4	2.4
Wheeze or whistling in the chest in last year	2.2	3.9	11.2	-0.6	0.1	-3.3
Qualifications: nursing, teaching	2.2	3.4	7.6	-1.6	2.8	-0.0
Cholesterol lowering medication	2.2	3.2	6.4	1.4	-1.2	-2.5
Age at First Birth	2.1	3.1	5.0	-2.2	2.0	0.2
Ever used hormone-replacement therapy (HRT)	2.1	2.6	3.5	1.9	-1.4	-1.6
Relative age voice broke	2.1	3.2	7.5	-1.4	2.7	-0.3
Nervous feelings	2.1	3.9	10.5	-1.1	3.2	0.1
Financial difficulties in last 2 years	2.1	2.8	5.8	1.4	-2.4	0.8
Medication: Blood pressure	2.1	3.7	6.7	1.3	-2.6	-1.7
Arm predicted mass (right)	2.1	10.6	15.8	-4.0	3.3	2.3
LDL Cholesterol	2.0	3.2	6.9	1.3	-2.6	1.0
Alcohol drinker status: Never	2.0	2.4	6.1	0.7	-0.7	-2.5
Rheumatoid Arthritis	1.9	2.6	7.9	0.0	0.0	-2.8
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.0	-2.2	0.5	1.2
Whole body fat-free mass	1.9	11.1	14.9	-3.9	3.6	2.3
Medication: Gliclazide	1.9	2.2	4.1	1.1	-1.1	-2.0
Whole body water mass	1.9	10.7	14.6	-3.8	3.5	2.3
Average weekly champagne plus white wine intake	1.9	2.7	4.5	-1.6	2.1	-1.0
Arm predicted mass (left)	1.9	9.9	14.2	-3.8	3.1	2.4
Alcohol intake frequency.	1.8	4.1	6.8	2.6	-1.1	-2.1
Arm fat-free mass (left)	1.8	8.9	12.4	-3.5	3.0	2.3
Supplements: Calcium	1.8	2.0	2.6	1.6	-1.6	-1.0
Ulcerative Colitis	1.7	2.5	7.4	0.0	-0.2	-2.7
Medication: Metformin	1.7	2.4	5.2	0.5	-1.3	-2.3
Loud music exposure frequency	1.7	1.9	4.1	0.1	-2.0	-1.3
Friendships satisfaction	1.7	2.1	3.9	-0.5	2.0	-1.5
HDL Cholesterol	1.6	2.7	4.8	-2.2	1.8	0.4
High blood pressure (mother)	1.6	2.3	4.5	2.1	-1.4	-0.6
Long-standing illness, disability or infirmity	1.6	2.4	5.4	0.8	-1.1	-2.3
Severe depression (siblings)	1.5	1.7	2.0	-1.2	1.4	1.3
Qualifications: None of the above	1.5	3.2	8.5	0.8	-2.9	-0.7
Risk taking	1.5	2.1	5.2	1.1	-2.3	-0.1
Heart disease (siblings)	1.5	1.9	3.9	0.3	-1.3	-2.0
Neuroticism (2016)	1.4	2.0	3.8	-1.2	2.0	-0.8
Primary Biliary Cirrhosis	1.4	1.9	5.6	0.5	0.2	-2.4
Illnesses of mother	1.4	1.7	3.4	-1.2	1.9	0.4
Eye problems/disorders: Cataract	1.4	1.6	3.7	-1.9	1.0	-0.4
Basal metabolic rate	1.4	7.5	10.2	-3.2	3.0	1.9
Gout (self-reported)	1.3	1.7	3.8	1.0	-1.9	-0.7
Intelligence (Savage-Jansen 2018)	1.2	3.8	11.1	-0.1	3.3	-0.5
Lung FEV1/FVC ratio	1.2	6.1	13.4	1.8	-1.2	3.7
Maternal smoking around birth	1.2	1.7	3.0	-0.5	-1.4	1.7
Sitting height	1.2	8.2	20.9	-1.7	1.0	4.6
Breastfed as a baby	1.2	1.4	1.8	1.2	-1.0	1.4
Loneliness, isolation	1.2	1.7	3.9	0.7	-0.9	-2.0
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.8	-1.7	1.0	0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.5	-1.1	0.5	1.9
Crohns Disease (2017)	1.1	2.4	5.5	-1.2	0.5	-2.3
Mean Putamen Volume	1.1	1.3	3.3	0.6	-0.4	1.8
BMI	1.1	6.2	7.1	2.7	-2.4	-2.5
Hearing difficulty/problems: Yes	1.1	1.7	3.9	2.0	-1.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	4.4	2.1	-1.8	-0.4
Illnesses of siblings	1.1	1.6	2.3	-0.5	1.5	1.4
Noisy workplace	1.1	1.4	2.9	0.2	-1.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.8	-0.7	-0.2	2.0
Migraine (self-reported)	1.1	1.4	2.1	1.5	-1.3	-0.6
Had major operations	1.1	1.3	1.7	0.9	-1.2	-1.3
Leg fat-free mass (right)	1.1	6.0	8.6	-2.9	2.8	1.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	1.3	-0.1	1.9
Osteoarthritis (self-reported)	1.1	1.4	2.8	-1.0	0.7	1.7
Smoking status: Current	1.1	1.8	3.9	-0.1	-1.2	2.0
Leg predicted mass (right)	1.1	5.9	8.3	-2.9	2.8	1.3
Schizophrenia vs Biploar Disorder	1.0	1.3	3.8	0.0	0.0	1.9
Lupus	1.0	1.5	4.0	-2.0	0.6	-0.4
Blood White Count	1.0	7.6	22.5	0.6	-0.2	-4.7
Lung FVC	1.0	5.1	6.2	-2.5	2.4	1.9
Diabetes (mother)	1.0	1.3	1.3	1.2	-1.1	-1.1
Current tobacco smoking	1.0	1.7	3.1	-0.3	-1.4	1.8
Leg predicted mass (left)	1.0	5.2	7.4	-2.7	2.5	1.3
Heart attack	1.0	1.3	2.5	-1.6	0.9	0.7
Arm fat percentage (right)	1.0	3.9	5.9	2.4	-1.9	-1.5
Happiness	1.0	1.2	3.2	-0.5	1.8	0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.8	-0.2	2.4	-0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	0.5	-1.6	-1.0
Medication: Amlodipine	1.0	1.4	2.2	0.9	-1.1	-1.5
Leg fat percentage (right)	1.0	3.6	4.8	2.0	-2.2	-1.4
Emphysema/chronic bronchitis	1.0	1.2	2.9	-1.7	0.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.3	1.1	0.0	-1.5
Suffer from ‘nerves’	1.0	1.6	3.4	-0.7	1.0	-1.8
Average weekly red wine intake	1.0	1.5	3.4	1.8	-1.0	-0.3
Commuting to job workplace: Walk	1.0	1.1	1.5	1.2	-0.7	-1.2
Leg fat percentage (left)	1.0	3.8	5.1	2.1	-2.3	-1.3
Bipolar Disorder (2018)	0.9	1.5	4.4	0.0	0.0	-2.1
Vitamin and mineral supplements	0.9	1.3	1.5	-1.1	1.2	1.0
Leg fat-free mass (left)	0.9	4.8	7.0	-2.6	2.4	1.2
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.8	-0.5	-1.1
Fluid intelligence score	0.9	1.8	4.3	0.3	2.1	-1.0
Headache pain in last month	0.9	1.6	2.0	1.3	-1.4	-1.1
Age at last live birth	0.9	1.3	2.2	-1.3	1.5	0.3
Arm fat percentage (left)	0.9	3.5	5.0	2.2	-1.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.0	-1.4	-0.6	0.9
Medication: Bendroflumethiazide	0.9	1.4	1.8	0.9	-1.3	1.2
Ever depressed for a whole week	0.9	1.1	2.3	-0.9	1.5	-0.2
Worry (Nagel 2018)	0.8	1.6	4.2	-0.7	2.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.9	0.5	2.0	-1.3
Average weekly fortified wine intake	0.8	0.9	1.8	0.8	-1.3	0.6
Stomach or abdominal pain in last month	0.8	1.0	1.2	-0.8	1.1	1.0
Pain all over the body in last month	0.8	0.8	1.5	0.3	-1.2	0.9
Time employed in main current job	0.8	0.9	2.3	-0.7	1.5	0.2
Worrier / anxious feelings	0.8	1.5	3.7	-0.7	1.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.7	-0.8	1.6	0.4
Worry too long after embarrassment	0.8	1.3	2.7	0.2	1.1	-1.6
Qualifications: College or University degree	0.8	2.6	6.8	-0.9	2.6	-0.6
Medication: Ibuprofen	0.8	1.0	2.6	0.1	-0.6	1.6
Heart disease (mother)	0.8	0.9	2.4	-0.6	0.3	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	0.1	-1.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.7	-1.0	0.5	-1.3
Ever smoked	0.8	1.4	3.7	0.7	-1.9	-0.1
Fractured/broken bones in last 5 years	0.8	1.0	2.6	0.6	-0.3	1.6
Commuting to job workplace: Cycle	0.8	1.0	2.2	1.5	-0.9	0.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.2	-0.5	-1.0	1.1
Body Mass Index (BMI) (2010)	0.7	0.9	1.7	0.7	-0.7	1.3
HbA1C	0.7	0.7	1.8	0.7	-1.3	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	1.7	-1.3	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	1.2	0.4	1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-0.8	1.2	0.6
Had other major operations	0.7	0.9	1.3	-0.1	-1.2	1.2
Mouth/teeth dental problems	0.7	1.1	1.5	-0.7	1.2	1.1
Hair/balding pattern: Pattern 3	0.7	1.0	1.5	0.8	-1.2	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	-1.3	0.9	-0.5
Angina (self-reported)	0.7	0.9	1.3	-1.1	0.4	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	-0.3	1.1	-1.2
Back pain experienced in last month	0.7	1.0	2.5	-0.6	0.4	1.6
Average weekly beer plus cider intake	0.7	1.1	1.5	1.1	-1.2	0.7
Unable to work because of sickness or disability	0.7	0.9	1.2	-1.0	0.8	1.1
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	0.4	-0.4	-1.8
Blood Platelet Count	0.6	6.6	12.4	-1.9	1.9	3.5
Chronotype (morning person)	0.6	1.5	2.1	-1.0	-1.5	1.1
Angina	0.6	0.7	1.1	-1.0	0.3	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	1.6	0.8	-1.3	0.4
Body mass index (BMI)	0.6	2.8	3.4	1.4	-1.8	-1.7
Alcohol intake versus 10 years previously	0.6	0.9	1.6	1.3	-0.7	0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	1.7	0.4	-1.0	-1.3
Medication: Lansoprazole	0.6	0.7	1.8	-1.4	0.4	0.2
Prospective memory result	0.6	0.7	2.0	0.0	-0.5	1.4
Peak expiratory flow (PEF)	0.6	1.5	3.2	-1.1	1.8	-0.3
Medication: Paracetamol	0.6	1.0	1.4	1.2	-0.5	1.1
Body fat percentage	0.6	2.2	2.8	1.7	-1.7	-1.0
Medication: Allopurinol	0.6	0.8	1.6	0.8	-1.3	0.4
Number of full sisters	0.6	0.8	1.4	0.1	-0.9	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.0	0.3	-1.4	0.4
Medication: Paracetamol	0.6	0.9	2.2	1.5	-0.2	0.7
Medication: Atorvastatin	0.6	0.8	1.4	0.2	-0.9	-1.2
Waist Hip Ratio (WHR)	0.5	2.4	5.4	-2.3	1.3	-0.6
Smoking Status	0.5	1.1	2.9	0.5	-1.7	0.4
Relative age of first facial hair	0.5	1.0	2.0	-1.1	1.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.1	-0.6	1.1
Number of incorrect matches in round	0.5	0.8	2.2	-0.2	1.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	-0.7	1.2	-0.4
Pulse rate	0.5	0.8	1.3	-0.8	1.1	-0.6
Depression (self-reported)	0.5	0.6	1.6	-0.2	1.3	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.4	-0.1	-1.2
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.9	0.3	1.1
Number of full brothers	0.5	0.7	1.6	0.6	-1.3	0.2
Neck or shoulder pain in last month	0.5	0.7	1.7	0.1	-1.3	0.5
Leg pain on walking	0.5	0.7	1.8	0.1	-0.4	-1.3
Knee pain experienced in last month	0.5	0.7	1.5	-0.4	0.8	-1.2
Mineral and other dietary supplements	0.5	0.7	1.8	-0.2	-0.3	1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	-0.0	-1.4	0.1
Mother’s age at death	0.5	0.6	1.4	0.4	0.6	1.2
Illnesses of father: High blood pressure	0.5	0.6	1.8	-0.2	1.3	0.2
Neuroticism (Nagel 2018)	0.4	0.9	1.3	-0.3	1.1	-1.1
Crohns Disease (2012)	0.4	0.7	1.7	0.4	-0.4	-1.3
Tanning	0.4	4.9	10.7	1.9	-3.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	-1.2	-0.1	0.0
Fed-up feelings	0.4	0.8	1.8	-0.0	0.8	-1.3
Medication: Atenolol	0.4	0.5	1.4	0.1	-1.2	-0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.4	0.1	-1.1
Weight	0.4	2.0	3.4	-1.9	1.3	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-0.4	1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	0.7	-0.1	-1.4
High blood pressure (siblings)	0.4	0.6	1.4	0.6	-1.2	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.1	-1.0	1.1	0.3
Medication: Seretide 50 evohaler	0.4	0.4	1.1	-0.1	-0.4	-1.0
Pulse rate, automated reading	0.4	1.2	2.3	-0.8	0.9	-1.5
Chest pain or discomfort	0.4	0.6	1.0	-0.9	0.1	1.0
Wears glasses or contact lenses	0.4	0.5	1.3	0.2	0.4	1.1
Ever taken oral contraceptive pill	0.4	0.5	0.7	-0.8	0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.2	0.1	-1.3
Medication: Lisinopril	0.4	0.5	0.6	-0.7	-0.8	-0.7
Irritability	0.4	0.7	1.3	0.8	-1.1	-0.3
Age started oral contraceptive pill	0.4	0.5	1.2	-1.1	0.5	0.0
Alcohol drinker status: Previous	0.4	0.4	0.8	0.9	-0.6	0.4
Breast Cancer	0.3	0.7	1.4	0.8	-1.2	0.3
Ovarian Cancer	0.3	0.4	0.5	-0.6	0.7	0.6
Heel T-Score	0.3	2.7	4.8	1.8	-2.2	0.3
Neuroticism	0.3	0.8	1.6	-0.8	1.3	-0.4
Average weekly spirits intake	0.3	0.4	0.8	0.5	-0.9	0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	0.7	0.6	0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.5	-0.1	-0.9
Multivitamins +/- minerals	0.3	0.3	0.6	0.7	-0.6	0.2
Impedance of leg (left)	0.3	1.5	4.4	-0.3	0.1	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	-0.4	1.0	0.1
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.4	-0.3	1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.6	-0.8	0.6	-0.6
Smoking status: Previous	0.3	0.5	0.8	0.0	-0.7	-0.9
Hearing aid user	0.3	0.3	0.7	0.3	-0.9	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.4	-0.1	0.9
Depression (Nagel 2018)	0.2	0.3	0.5	0.4	-0.7	0.4
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.2	0.7	-0.9
Sensitivity / hurt feelings	0.2	0.3	0.5	0.2	0.6	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	-0.5	-0.1
Supplements: Zinc	0.2	0.3	0.6	0.4	-0.2	-0.8
Medication: Co-codamol	0.2	0.2	0.6	0.3	0.0	0.7
Impedance of leg (right)	0.2	1.0	3.0	-0.3	0.1	1.7
Trunk fat percentage	0.2	0.6	0.8	0.8	-0.9	-0.6
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.3	0.0	0.7
Past tobacco smoking	0.2	0.3	0.9	0.2	1.0	0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.9	0.2	-0.4
Neuroticism score	0.2	0.4	0.6	0.0	0.8	-0.7
Falls in the last year	0.2	0.3	0.5	0.7	-0.1	-0.6
Number of live births	0.2	0.3	0.8	-0.9	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.5	-0.7	0.1
Lung cancer (father)	0.2	0.3	0.6	0.1	0.5	0.8
Number of children fathered	0.2	0.2	0.5	-0.7	-0.3	0.1
Medication: Omeprazole	0.2	0.2	0.6	-0.3	0.8	0.1
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.5	0.7	0.1
Mood swings	0.2	0.4	1.1	0.3	-0.1	-1.0
Ever had bowel cancer screening	0.2	0.3	0.8	0.9	0.1	-0.1
Breast cancer (self-reported)	0.2	0.2	0.6	-0.3	0.2	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.6	0.1	0.6
Impedance of whole body	0.2	1.0	3.1	0.1	0.2	1.8
Bipolar Disorder or Schizophrenia	0.1	0.4	1.1	0.0	0.0	-1.0
Reaction Time	0.1	0.2	0.5	0.2	-0.3	-0.7
Prostate Cancer	0.1	0.2	0.3	-0.3	0.3	0.5
Systolic Blood Pressure	0.1	0.5	0.9	0.9	-0.7	0.3
Hair Pigment	0.1	2.5	4.8	-1.4	2.2	1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.1	-0.1	-0.5
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.7	0.1	0.1
Pack years adult smoking proportion	0.1	0.2	0.6	0.3	-0.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	0.3	-0.2
Supplements: Glucosamine	0.1	0.2	0.4	0.2	0.6	0.4
Waist circumference	0.1	0.4	0.9	-0.2	-0.6	-0.9
Had menopause	0.1	0.1	0.3	0.3	-0.0	-0.5
Impedance of arm (right)	0.1	0.5	0.9	1.0	-0.1	0.7
Impedance of arm (left)	0.1	0.4	0.7	0.7	0.1	0.9
Arm fat mass (right)	0.1	0.4	0.5	0.7	-0.6	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.5	0.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.4	0.7	0.0
Comparative body size at age 10	0.1	0.3	0.6	-0.3	-0.3	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.4	0.0	-0.2
Overall health rating	0.1	0.2	0.6	-0.7	0.1	-0.4
Family relationship satisfaction	0.1	0.1	0.2	0.1	0.5	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	0.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.3	0.4
Arm fat mass (left)	0.1	0.5	0.7	0.9	-0.6	-0.7
Miserableness	0.1	0.2	0.3	0.3	-0.5	-0.2
Guilty feelings	0.1	0.1	0.2	-0.1	0.5	-0.3
Financial situation satisfaction	0.1	0.1	0.4	-0.1	-0.6	0.1
Myopia	0.1	0.2	0.2	0.5	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	0.3	0.5
Pain experienced in last month	0.1	0.1	0.2	-0.0	0.4	-0.4
Pack years of smoking	0.1	0.1	0.3	0.0	0.1	0.6
Leg fat mass (left)	0.1	0.3	0.7	0.4	-0.8	-0.4
Schizophrenia (2018)	0.0	0.0	0.1	0.0	0.0	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	-0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.1	0.0	0.0	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Age when periods started (menarche)	0.0	0.1	0.2	0.3	0.4	-0.1
Trunk fat mass	0.0	0.1	0.3	-0.5	0.3	-0.0
Hip circumference	0.0	0.1	0.2	0.5	-0.0	-0.3
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2	-0.0
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.2	-0.3	-0.2
Mean time to correctly identify matches	0.0	0.1	0.1	-0.2	-0.3	-0.1
Whole body fat mass	0.0	0.0	0.1	-0.1	-0.0	-0.3
Leg fat mass (right)	0.0	0.2	0.4	0.2	-0.6	-0.3
Number of operations (self-reported)	0.0	0.1	0.1	0.2	-0.4	0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.2	-0.1	-0.2

Hub : Genes

F12

Models

Trait associations