Hub : Genes

F12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Liver Hepatocellular Carcinoma	0.1590	0.0710	0.0011	0.064	0.010	0.114	NA	0.111	6.0e-04	0.1100	5.2e-06	NA	7.0e-06
2	TCGA	Prostate Adenocarcinoma	0.0544	0.0274	0.0017	0.033	0.017	0.030	NA	0.022	1.9e-04	0.0054	4.0e-04	NA	2.0e-03
3	TCGA	Skin Cutaneous Melanoma	0.1480	0.0860	0.0040	0.193	0.103	0.083	NA	0.185	7.0e-06	0.0011	3.2e-03	NA	1.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.5	4.4	0.0	0.0	-2.1
Bipolar Disorder or Schizophrenia	0.1	0.4	1.1	0.0	0.0	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	0.4	-0.4	-1.8
Depression (Nagel 2018)	0.2	0.3	0.5	0.4	-0.7	0.4
Intelligence (Savage-Jansen 2018)	1.2	3.8	11.1	-0.1	3.3	-0.5
Neuroticism (Nagel 2018)	0.4	0.9	1.3	-0.3	1.1	-1.1
Schizophrenia (2018)	0.0	0.0	0.1	0.0	0.0	0.4
Schizophrenia vs Biploar Disorder	1.0	1.3	3.8	0.0	0.0	1.9
Worry (Nagel 2018)	0.8	1.6	4.2	-0.7	2.1	-0.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.2	-0.5	-1.0	1.1
Alzheimer’s Disease (in father)	2.2	2.3	4.2	-1.0	1.4	2.0
Alzheimer’s Disease (including proxy)	1.1	1.6	3.5	-1.1	0.5	1.9
Crohns Disease (2017)	1.1	2.4	5.5	-1.2	0.5	-2.3
Irritable Bowel Disease (IBD)	2.8	6.6	17.0	-1.5	0.7	-4.1
Ulcerative Colitis (UC)	3.1	5.7	15.1	-1.3	0.7	-3.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.2	0.5	0.2	-0.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.9	0.5	2.0	-1.3
Breast Cancer	0.3	0.7	1.4	0.8	-1.2	0.3
Ovarian Cancer	0.3	0.4	0.5	-0.6	0.7	0.6
Prostate Cancer	0.1	0.2	0.3	-0.3	0.3	0.5
Age at First Birth	2.1	3.1	5.0	-2.2	2.0	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.7	0.7	-0.7	1.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	1.7	0.4	-0.4	-1.3
Mean Putamen Volume	1.1	1.3	3.3	0.6	-0.4	1.8
Fasting Glucose	0.0	0.0	0.0	0.0	-0.0	0.0
HbA1C	0.7	0.7	1.8	0.7	-1.3	0.0
HDL Cholesterol	1.6	2.7	4.8	-2.2	1.8	0.4
LDL Cholesterol	2.0	3.2	6.9	1.3	-2.6	1.0
Lupus	1.0	1.5	4.0	-2.0	0.6	-0.4
Neuroticism (2016)	1.4	2.0	3.8	-1.2	2.0	-0.8
Primary Biliary Cirrhosis	1.4	1.9	5.6	0.5	0.2	-2.4
Rheumatoid Arthritis	1.9	2.6	7.9	0.0	0.0	-2.8
Schizophrenia (2014)	0.0	0.0	0.1	0.0	0.0	0.3
Triglycerides	4.1	6.8	9.4	3.1	-3.0	-1.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.7	2.5	7.4	0.0	-0.2	-2.7
Blood Eosinophil Count	3.0	23.3	67.1	1.5	-0.8	-8.2
Blood Platelet Count	0.6	6.6	12.4	-1.9	1.9	3.5
Blood Red Count	5.6	54.5	96.8	5.8	-5.8	-9.8
Blood White Count	1.0	7.6	22.5	0.6	-0.2	-4.7
Heel T-Score	0.3	2.7	4.8	1.8	-2.2	0.3
BMI	1.1	6.2	7.1	2.7	-2.4	-2.5
Height	5.3	101.6	135.7	-11.6	10.7	7.4
Waist Hip Ratio (WHR)	0.5	2.4	5.4	-2.3	1.3	-0.6
Systolic Blood Pressure	0.1	0.5	0.9	0.9	-0.7	0.3
Smoking Status	0.5	1.1	2.9	0.5	-1.7	0.4
Allergy or Eczema	3.4	8.9	23.1	1.4	-1.2	-4.8
Cardiovascular Disease	4.3	14.2	25.3	3.5	-5.0	-2.3
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.2	0.7	-0.9
Respiratory disease	3.4	7.6	22.3	0.2	-0.8	-4.7
Type 2 Diabetes (T2D) (2018)	4.0	7.4	13.6	1.7	-2.4	-3.7
Lung FEV1/FVC ratio	1.2	6.1	13.4	1.8	-1.2	3.7
Lung FVC	1.0	5.1	6.2	-2.5	2.4	1.9
Neuroticism	0.3	0.8	1.6	-0.8	1.3	-0.4
Chronotype (morning person)	0.6	1.5	2.1	-1.0	-1.5	1.1
Hair Pigment	0.1	2.5	4.8	-1.4	2.2	1.0
Tanning	0.4	4.9	10.7	1.9	-3.3	-0.6
Hand grip strength (left)	4.1	10.7	16.0	-3.2	4.0	2.5
Number of treatments/medications taken	3.3	5.9	9.0	1.4	-2.6	-3.0
Average weekly spirits intake	0.3	0.4	0.8	0.5	-0.9	0.5
Sensitivity / hurt feelings	0.2	0.3	0.5	0.2	0.6	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.1	-0.1	-0.5
Hearing difficulty/problems: Yes	1.1	1.7	3.9	2.0	-1.0	0.5
Relative age of first facial hair	0.5	1.0	2.0	-1.1	1.4	0.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	8.2	0.4	-0.2	-2.9
Ever used hormone-replacement therapy (HRT)	2.1	2.6	3.5	1.9	-1.4	-1.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	0.7	0.6	0.3
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.7	0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	-1.2	-0.1	0.0
Angina	0.6	0.7	1.1	-1.0	0.3	-1.1
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	-0.5	-0.1
Vitamin and mineral supplements	0.9	1.3	1.5	-1.1	1.2	1.0
Supplements: Zinc	0.2	0.3	0.6	0.4	-0.2	-0.8
Medication: Co-codamol	0.2	0.2	0.6	0.3	0.0	0.7
Medication: Metformin	1.7	2.4	5.2	0.5	-1.3	-2.3
Diabetes (father)	3.2	3.9	6.4	2.5	-1.3	-1.9
Diabetes (mother)	1.0	1.3	1.3	1.2	-1.1	-1.1
Severe depression (siblings)	1.5	1.7	2.0	-1.2	1.4	1.3
Pack years adult smoking proportion	0.1	0.2	0.6	0.3	-0.1	0.7
Impedance of leg (right)	0.2	1.0	3.0	-0.3	0.1	1.7
Leg fat-free mass (left)	0.9	4.8	7.0	-2.6	2.4	1.2
Trunk fat percentage	0.2	0.6	0.8	0.8	-0.9	-0.6
Hand grip strength (right)	2.4	6.5	10.7	-2.4	3.3	1.7
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	-0.2	0.3
Current tobacco smoking	1.0	1.7	3.1	-0.3	-1.4	1.8
Average weekly fortified wine intake	0.8	0.9	1.8	0.8	-1.3	0.6
Maternal smoking around birth	1.2	1.7	3.0	-0.5	-1.4	1.7
Fed-up feelings	0.4	0.8	1.8	-0.0	0.8	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.3	0.0	0.7
Relative age voice broke	2.1	3.2	7.5	-1.4	2.7	-0.3
Taking other prescription medications	2.9	4.5	13.1	0.5	-0.3	-3.6
Age when periods started (menarche)	0.0	0.1	0.2	0.3	0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.1	-0.6	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	1.7	-1.3	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	0.3	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.6	0.8	-1.3	0.4
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.5	-0.1	-0.9
High blood pressure	3.4	9.5	16.3	2.7	-4.0	-2.3
Hayfever, allergic rhinitis or eczema	2.3	4.9	13.8	0.8	-0.6	-3.7
Multivitamins +/- minerals	0.3	0.3	0.6	0.7	-0.6	0.2
Stomach or abdominal pain in last month	0.8	1.0	1.2	-0.8	1.1	1.0
Supplements: Glucosamine	0.1	0.2	0.4	0.2	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	1.2	0.4	1.0
Medication: Atenolol	0.4	0.5	1.4	0.1	-1.2	-0.3
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.8	-0.5	-1.1
Sitting height	1.2	8.2	20.9	-1.7	1.0	4.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-0.8	1.2	0.6
High blood pressure (mother)	1.6	2.3	4.5	2.1	-1.4	-0.6
Body mass index (BMI)	0.6	2.8	3.4	1.4	-1.8	-1.7
Impedance of leg (left)	0.3	1.5	4.4	-0.3	0.1	2.1
Leg predicted mass (left)	1.0	5.2	7.4	-2.7	2.5	1.3
Trunk fat mass	0.0	0.1	0.3	-0.5	0.3	-0.0
Waist circumference	0.1	0.4	0.9	-0.2	-0.6	-0.9
Number of incorrect matches in round	0.5	0.8	2.2	-0.2	1.5	-0.4
Past tobacco smoking	0.2	0.3	0.9	0.2	1.0	0.2
Alcohol usually taken with meals	2.4	3.9	5.8	1.8	-1.7	-2.4
Nervous feelings	2.1	3.9	10.5	-1.1	3.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	-0.4	1.0	0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.9	0.2	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.4	0.1	-1.1
Had menopause	0.1	0.1	0.3	0.3	-0.0	-0.5
Had other major operations	0.7	0.9	1.3	-0.1	-1.2	1.2
Forced vital capacity (FVC)	5.4	20.9	31.9	-5.0	5.6	2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	4.4	2.1	-1.8	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	-0.7	1.2	-0.4
Qualifications: None of the above	1.5	3.2	8.5	0.8	-2.9	-0.7
Financial difficulties in last 2 years	2.1	2.8	5.8	1.4	-2.4	0.8
Mouth/teeth dental problems	0.7	1.1	1.5	-0.7	1.2	1.1
Heart attack	1.0	1.3	2.5	-1.6	0.9	0.7
Allergy	2.3	5.3	14.1	-0.5	1.2	3.8
Pain all over the body in last month	0.8	0.8	1.5	0.3	-1.2	0.9
Diabetes (self-reported)	2.5	3.8	7.6	0.7	-1.9	-2.8
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	4.2	1.8	-1.5	-2.1
Medication: Ramipril	3.5	4.4	5.5	1.6	-2.3	-2.3
Medication: Simvastatin	3.9	5.8	7.1	2.3	-2.7	-2.2
Fluid intelligence score	0.9	1.8	4.3	0.3	2.1	-1.0
Illnesses of siblings	1.1	1.6	2.3	-0.5	1.5	1.4
Neuroticism score	0.2	0.4	0.6	0.0	0.8	-0.7
Weight	0.4	2.0	3.4	-1.9	1.3	0.9
Impedance of arm (right)	0.1	0.5	0.9	1.0	-0.1	0.7
Arm fat percentage (right)	1.0	3.9	5.9	2.4	-1.9	-1.5
Trunk fat-free mass	2.6	15.0	18.5	-4.3	4.2	3.0
Hip circumference	0.0	0.1	0.2	0.5	-0.0	-0.3
Time employed in main current job	0.8	0.9	2.3	-0.7	1.5	0.2
Alcohol intake versus 10 years previously	0.6	0.9	1.6	1.3	-0.7	0.8
Father’s age at death	3.7	4.9	6.8	2.6	-2.1	-1.9
Worrier / anxious feelings	0.8	1.5	3.7	-0.7	1.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-0.4	1.2	0.4
Falls in the last year	0.2	0.3	0.5	0.7	-0.1	-0.6
Hair/balding pattern: Pattern 3	0.7	1.0	1.5	0.8	-1.2	0.8
Number of live births	0.2	0.3	0.8	-0.9	0.3	0.2
Forced expiratory volume in 1-second (FEV1)	3.4	11.5	18.9	-3.1	4.3	2.5
Pulse rate	0.5	0.8	1.3	-0.8	1.1	-0.6
Happiness	1.0	1.2	3.2	-0.5	1.8	0.1
Noisy workplace	1.1	1.4	2.9	0.2	-1.7	1.1
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.8	-0.2	2.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.5	-0.7	0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	1.7	0.4	-1.0	-1.3
Asthma	2.9	5.7	16.3	0.3	-0.9	-4.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.8	-0.7	-0.2	2.0
Medication: Cholesterol lowering	2.7	4.3	6.0	2.1	-2.5	-1.6
Depression (self-reported)	0.5	0.6	1.6	-0.2	1.3	0.2
Medication: Lansoprazole	0.6	0.7	1.8	-1.4	0.4	0.2
Prospective memory result	0.6	0.7	2.0	0.0	-0.5	1.4
Lung cancer (father)	0.2	0.3	0.6	0.1	0.5	0.8
Illnesses of mother	1.4	1.7	3.4	-1.2	1.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.6	22.1	-3.6	4.7	3.4
Pulse wave Arterial Stiffness index	3.9	4.5	5.5	2.4	-2.2	-1.8
Impedance of arm (left)	0.1	0.4	0.7	0.7	0.1	0.9
Arm fat mass (right)	0.1	0.4	0.5	0.7	-0.6	-0.6
Trunk predicted mass	2.7	15.1	18.9	-4.3	4.2	3.0
Standing height	4.7	46.4	55.5	-7.4	7.1	5.7
Length of working week for main job	2.6	2.9	3.4	1.6	-1.9	-1.6
Exposure to tobacco smoke at home	3.7	4.2	8.5	1.7	-2.9	-1.1
Breastfed as a baby	1.2	1.4	1.8	1.2	-1.0	1.4
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.5	0.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.4	0.7	0.0
Birth weight of first child	4.5	8.1	13.8	-1.8	3.7	2.7
Peak expiratory flow (PEF)	0.6	1.5	3.2	-1.1	1.8	-0.3
Pulse wave reflection index	5.8	7.2	11.5	3.4	-3.1	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.4	-0.1	-1.2
Loud music exposure frequency	1.7	1.9	4.1	0.1	-2.0	-1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.7	-0.8	1.6	0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	0.5	-1.6	-1.0
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.9	0.3	1.1
Medication: Paracetamol	0.6	1.0	1.4	1.2	-0.5	1.1
Headache pain in last month	0.9	1.6	2.0	1.3	-1.4	-1.1
Medication for cholesterol, blood pressure or diabetes	3.8	6.2	11.3	-2.1	3.4	1.8
Glaucoma (self-reported)	3.3	3.8	6.4	-2.2	2.5	0.5
Gout (self-reported)	1.3	1.7	3.8	1.0	-1.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	0.7	-0.1	-1.4
Medication: Amlodipine	1.0	1.4	2.2	0.9	-1.1	-1.5
Medication: Ventolin 100micrograms inhaler	2.2	2.9	7.7	-0.7	-0.7	-2.8
Birth weight	4.0	8.7	12.1	-2.4	3.5	2.8
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	-1.3	0.9	-0.5
High blood pressure (siblings)	0.4	0.6	1.4	0.6	-1.2	-0.4
Forced vital capacity (FVC), Best measure	6.1	22.3	33.0	-5.1	5.7	2.8
Body fat percentage	0.6	2.2	2.8	1.7	-1.7	-1.0
Leg fat percentage (right)	1.0	3.6	4.8	2.0	-2.2	-1.4
Arm fat-free mass (right)	2.2	11.4	17.1	-4.1	3.4	2.4
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	0.3	0.4
Comparative body size at age 10	0.1	0.3	0.6	-0.3	-0.3	-0.8
Number of full brothers	0.5	0.7	1.6	0.6	-1.3	0.2
Worry too long after embarrassment	0.8	1.3	2.7	0.2	1.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.4	-0.3	1.0
Wheeze or whistling in the chest in last year	2.2	3.9	11.2	-0.6	0.1	-3.3
Number of children fathered	0.2	0.2	0.5	-0.7	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.4	0.0	-0.2
Age at first live birth	3.0	5.3	8.6	-2.7	2.9	0.0
Pulse wave peak to peak time	5.9	7.0	8.1	-2.8	2.8	2.2
Health satisfaction	2.3	2.9	5.4	-2.3	1.8	0.3
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.2	-0.3	-0.2
Qualifications: College or University degree	0.8	2.6	6.8	-0.9	2.6	-0.6
Eye problems/disorders: None of the above	4.5	5.2	8.9	3.0	-2.1	-1.5
Mouth/teeth dental problems: Loose teeth	5.2	6.2	12.3	1.0	-2.3	-3.5
Emphysema/chronic bronchitis	1.0	1.2	2.9	-1.7	0.3	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	1.1	-1.0	1.1	0.3
Neck or shoulder pain in last month	0.5	0.7	1.7	0.1	-1.3	0.5
Medication: Blood pressure	2.1	3.7	6.7	1.3	-2.6	-1.7
Angina (self-reported)	0.7	0.9	1.3	-1.1	0.4	-1.2
Migraine (self-reported)	1.1	1.4	2.1	1.5	-1.3	-0.6
Medication: Ibuprofen	0.8	1.0	2.6	0.1	-0.6	1.6
Medication: Allopurinol	0.6	0.8	1.6	0.8	-1.3	0.4
Medication: Omeprazole	0.2	0.2	0.6	-0.3	0.8	0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.1	-0.1	-0.4	-1.0
Mean time to correctly identify matches	0.0	0.1	0.1	-0.2	-0.3	-0.1
Heart disease (mother)	0.8	0.9	2.4	-0.6	0.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.3	1.1	0.0	-1.5
Whole body fat mass	0.0	0.0	0.1	-0.1	-0.0	-0.3
Leg fat mass (right)	0.0	0.2	0.4	0.2	-0.6	-0.3
Arm predicted mass (right)	2.1	10.6	15.8	-4.0	3.3	2.3
Pulse rate, automated reading	0.4	1.2	2.3	-0.8	0.9	-1.5
Alcohol intake frequency.	1.8	4.1	6.8	2.6	-1.1	-2.1
Comparative height size at age 10	4.8	26.3	37.2	-6.1	5.1	4.0
Number of full sisters	0.6	0.8	1.4	0.1	-0.9	-1.2
Suffer from ‘nerves’	1.0	1.6	3.4	-0.7	1.0	-1.8
Overall health rating	0.1	0.2	0.6	-0.7	0.1	-0.4
Chest pain or discomfort	0.4	0.6	1.0	-0.9	0.1	1.0
Had major operations	1.1	1.3	1.7	0.9	-1.2	-1.3
Age at last live birth	0.9	1.3	2.2	-1.3	1.5	0.3
Family relationship satisfaction	0.1	0.1	0.2	0.1	0.5	0.0
Leg pain on walking	0.5	0.7	1.8	0.1	-0.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	0.1	-1.5	-0.7
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.0	-2.2	0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	-0.3	1.1	-1.2
Medication: Aspirin	5.5	7.3	9.7	2.0	-2.9	-3.1
Supplements: Vitamin C	3.2	3.8	4.4	1.9	-2.1	-1.8
Knee pain experienced in last month	0.5	0.7	1.5	-0.4	0.8	-1.2
Hypertension (Self-reported)	4.0	11.0	19.8	2.9	-4.5	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	5.1	-1.8	2.3	0.1
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.5	0.7	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.6	-0.8	0.6	-0.6
Smoking status: Previous	0.3	0.5	0.8	0.0	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.9	8.1	-2.6	2.8	1.6
Whole body fat-free mass	1.9	11.1	14.9	-3.9	3.6	2.3
Leg fat-free mass (right)	1.1	6.0	8.6	-2.9	2.8	1.3
Arm fat percentage (left)	0.9	3.5	5.0	2.2	-1.8	-1.5
Average weekly red wine intake	1.0	1.5	3.4	1.8	-1.0	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	0.0	0.5
Mood swings	0.2	0.4	1.1	0.3	-0.1	-1.0
Loneliness, isolation	1.2	1.7	3.9	0.7	-0.9	-2.0
Long-standing illness, disability or infirmity	1.6	2.4	5.4	0.8	-1.1	-2.3
Ever had bowel cancer screening	0.2	0.3	0.8	0.9	0.1	-0.1
Diabetes diagnosed by doctor	2.9	4.7	9.7	1.0	-1.9	-3.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.3	0.4
Friendships satisfaction	1.7	2.1	3.9	-0.5	2.0	-1.5
Qualifications: nursing, teaching	2.2	3.4	7.6	-1.6	2.8	-0.0
Commuting to job workplace: Walk	1.0	1.1	1.5	1.2	-0.7	-1.2
Eye problems/disorders: Cataract	1.4	1.6	3.7	-1.9	1.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	1.3	-0.1	1.9
Medication for cholesterol	4.0	6.0	10.0	-2.3	3.2	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.0	-1.4	-0.6	0.9
Back pain experienced in last month	0.7	1.0	2.5	-0.6	0.4	1.6
Mineral and other dietary supplements	0.5	0.7	1.8	-0.2	-0.3	1.4
Breast cancer (self-reported)	0.2	0.2	0.6	-0.3	0.2	0.8
Asthma (self-reported)	3.5	7.0	19.5	0.4	-1.1	-4.4
Osteoporosis (self-reported)	2.3	2.8	5.5	-1.3	1.1	2.3
Osteoarthritis (self-reported)	1.1	1.4	2.8	-1.0	0.7	1.7
Medication: Aspirin	5.6	7.4	9.9	2.0	-2.9	-3.1
Medication: Gliclazide	1.9	2.2	4.1	1.1	-1.1	-2.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	-0.0	-1.4	0.1
Smoking status: Current	1.1	1.8	3.9	-0.1	-1.2	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.0	-2.5	3.0	2.0
Whole body water mass	1.9	10.7	14.6	-3.8	3.5	2.3
Leg predicted mass (right)	1.1	5.9	8.3	-2.9	2.8	1.3
Arm fat mass (left)	0.1	0.5	0.7	0.9	-0.6	-0.7
Number of self-reported non-cancer illnesses	4.9	8.6	11.3	2.6	-3.4	-2.8
Average weekly champagne plus white wine intake	1.9	2.7	4.5	-1.6	2.1	-1.0
Miserableness	0.1	0.2	0.3	0.3	-0.5	-0.2
Guilty feelings	0.1	0.1	0.2	-0.1	0.5	-0.3
Wears glasses or contact lenses	0.4	0.5	1.3	0.2	0.4	1.1
Ever taken oral contraceptive pill	0.4	0.5	0.7	-0.8	0.4	-0.8
Hearing aid user	0.3	0.3	0.7	0.3	-0.9	0.3
Mother’s age at death	0.5	0.6	1.4	0.4	0.6	1.2
Financial situation satisfaction	0.1	0.1	0.4	-0.1	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.0	0.3	-1.4	0.4
Commuting to job workplace: Public transport	3.3	3.9	6.0	2.5	-0.7	-2.3
Eye problems/disorders: Glaucoma	3.1	3.7	5.8	-2.4	2.1	0.9
Medication: Blood pressure	4.0	7.6	14.1	2.3	-3.8	-1.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.7	-1.0	0.5	-1.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.2	0.1	-1.3
High cholesterol (Self-reported)	3.7	6.6	11.9	2.4	-3.5	-1.5
Medication: Bendroflumethiazide	0.9	1.4	1.8	0.9	-1.3	1.2
Medication: Paracetamol	0.6	0.9	2.2	1.5	-0.2	0.7
Medication: Lisinopril	0.4	0.5	0.6	-0.7	-0.8	-0.7
Medication: Atorvastatin	0.6	0.8	1.4	0.2	-0.9	-1.2
Illnesses of father: High blood pressure	0.5	0.6	1.8	-0.2	1.3	0.2
Alcohol drinker status: Never	2.0	2.4	6.1	0.7	-0.7	-2.5
Ever smoked	0.8	1.4	3.7	0.7	-1.9	-0.1
Basal metabolic rate	1.4	7.5	10.2	-3.2	3.0	1.9
Leg fat percentage (left)	1.0	3.8	5.1	2.1	-2.3	-1.3
Arm fat-free mass (left)	1.8	8.9	12.4	-3.5	3.0	2.3
Number of operations (self-reported)	0.0	0.1	0.1	0.2	-0.4	0.0
Average weekly beer plus cider intake	0.7	1.1	1.5	1.1	-1.2	0.7
Irritability	0.4	0.7	1.3	0.8	-1.1	-0.3
Risk taking	1.5	2.1	5.2	1.1	-2.3	-0.1
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.2	-0.1	-0.2
Fractured/broken bones in last 5 years	0.8	1.0	2.6	0.6	-0.3	1.6
Age started oral contraceptive pill	0.4	0.5	1.2	-1.1	0.5	0.0
Diastolic blood pressure, automated reading	2.6	8.0	12.0	3.5	-3.4	-0.6
Ever depressed for a whole week	0.9	1.1	2.3	-0.9	1.5	-0.2
Unable to work because of sickness or disability	0.7	0.9	1.2	-1.0	0.8	1.1
Commuting to job workplace: Cycle	0.8	1.0	2.2	1.5	-0.9	0.0
Myopia	0.1	0.2	0.2	0.5	0.3	-0.5
Vascular/heart problems diagnosed by doctor	3.0	8.2	14.0	-2.2	3.7	2.4
Cholesterol lowering medication	2.2	3.2	6.4	1.4	-1.2	-2.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	0.3	0.5
Pain experienced in last month	0.1	0.1	0.2	-0.0	0.4	-0.4
Supplements: Calcium	1.8	2.0	2.6	1.6	-1.6	-1.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.4	-0.1	0.9
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.8	-1.7	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.6	0.1	0.6
Heart disease (siblings)	1.5	1.9	3.9	0.3	-1.3	-2.0
Alcohol drinker status: Previous	0.4	0.4	0.8	0.9	-0.6	0.4
Pack years of smoking	0.1	0.1	0.3	0.0	0.1	0.6
Impedance of whole body	0.2	1.0	3.1	0.1	0.2	1.8
Leg fat mass (left)	0.1	0.3	0.7	0.4	-0.8	-0.4
Arm predicted mass (left)	1.9	9.9	14.2	-3.8	3.1	2.4