[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr1:91,271,668-94,534,354

Best TWAS P=1.79e-26 · Best GWAS P=2.04e-26 conditioned to 0.856

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DR1	0.21	0.20	blup	305	0.23	1.8e-27	-9.5	-8.6	7.3e-18	0.89	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100131564	0.39	0.53	bslmm	315	0.54	9.6e-78	-9.1	9.2	4.8e-20	-0.75	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMED5	0.06	0.07	enet	20	0.09	6.7e-11	-10.6	10.3	7.1e-25	-0.91	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	DR1	0.18	0.14	lasso	6	0.12	3.7e-10	-9.1	-9.5	1.9e-21	0.80	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CCDC18	0.06	0.00	lasso	6	0.01	2.1e-02	-9.2	7.0	3.1e-12	-0.67	0.05	0.80	FALSE
6	GTEx	Adipose Subcutaneous	RP4-717I23.3	0.34	0.39	lasso	7	0.44	2.5e-39	-9.1	9.2	3.1e-20	-0.79	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	DR1	0.10	0.05	lasso	5	0.06	5.0e-04	-7.5	-9.6	5.9e-22	0.77	0.54	0.35	FALSE
8	GTEx	Adipose Visceral Omentum	RP4-717I23.3	0.28	0.32	enet	19	0.34	1.4e-18	-9.1	9.2	3.3e-20	-0.79	1.00	0.00	FALSE
9	GTEx	Adrenal Gland	SNORD21	0.20	0.09	enet	28	0.11	7.1e-05	1.7	7.1	1.2e-12	-0.45	0.10	0.19	FALSE
10	GTEx	Adrenal Gland	RP4-717I23.3	0.47	0.49	enet	30	0.53	5.5e-22	-9.1	9.2	3.5e-20	-0.77	1.00	0.00	FALSE
11	GTEx	Artery Aorta	DR1	0.15	0.10	lasso	5	0.14	3.1e-08	-9.1	-10.1	5.1e-24	0.87	0.24	0.76	FALSE
12	GTEx	Artery Aorta	RP4-717I23.3	0.26	0.36	lasso	5	0.33	4.6e-19	-9.1	9.2	5.5e-20	-0.79	1.00	0.00	FALSE
13	GTEx	Artery Coronary	RP4-717I23.3	0.14	0.17	lasso	5	0.17	3.1e-06	-9.1	9.1	6.9e-20	-0.80	0.16	0.80	FALSE
14	GTEx	Artery Tibial	DR1	0.17	0.11	lasso	8	0.18	5.9e-14	-9.5	-10.3	4.6e-25	0.90	0.03	0.97	FALSE
15	GTEx	Artery Tibial	RP4-717I23.3	0.22	0.32	lasso	11	0.36	9.0e-30	-9.1	9.8	9.6e-23	-0.83	1.00	0.00	FALSE
16	GTEx	Brain Caudate basal ganglia	RP4-717I23.3	0.43	0.46	enet	24	0.48	9.2e-16	-9.1	9.3	2.0e-20	-0.82	0.73	0.27	FALSE
17	GTEx	Brain Cerebellar Hemisphere	CDC7	0.28	0.18	lasso	3	0.14	2.6e-04	-5.7	5.4	6.9e-08	0.03	0.05	0.87	FALSE
18	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	-9.3	9.4	7.7e-21	-0.72	0.22	0.40	FALSE
19	GTEx	Brain Cerebellar Hemisphere	RP4-717I23.3	0.44	0.40	lasso	6	0.48	5.8e-14	-9.0	10.2	2.2e-24	-0.84	0.22	0.78	FALSE
20	GTEx	Brain Cerebellum	DR1	0.17	0.10	enet	23	0.12	2.2e-04	-9.2	-7.1	1.3e-12	0.84	0.01	0.95	FALSE
21	GTEx	Brain Cerebellum	RP4-717I23.3	0.48	0.53	enet	32	0.57	2.9e-20	-9.1	10.4	3.5e-25	-0.89	0.21	0.79	FALSE
22	GTEx	Brain Cortex	RP4-717I23.3	0.39	0.37	enet	19	0.42	1.0e-12	-9.1	9.4	6.0e-21	-0.81	0.54	0.46	FALSE
23	GTEx	Brain Frontal Cortex BA9	RP4-717I23.3	0.48	0.53	lasso	12	0.53	1.6e-16	-9.2	9.4	7.6e-21	-0.82	0.11	0.89	FALSE
24	GTEx	Brain Hippocampus	RP4-717I23.3	0.28	0.24	lasso	7	0.22	8.0e-06	-9.1	9.3	1.2e-20	-0.79	0.13	0.85	FALSE
25	GTEx	Brain Hypothalamus	RP4-717I23.3	0.33	0.35	enet	25	0.37	1.1e-09	-9.1	9.4	6.5e-21	-0.82	0.16	0.84	FALSE
26	GTEx	Brain Nucleus accumbens basal ganglia	RP4-717I23.3	0.50	0.42	lasso	5	0.47	3.0e-14	-9.2	9.5	1.6e-21	-0.82	0.31	0.69	FALSE
27	GTEx	Brain Putamen basal ganglia	RP4-717I23.3	0.38	0.34	enet	37	0.34	9.1e-09	-9.2	9.0	3.2e-19	-0.75	0.50	0.47	FALSE
28	GTEx	Breast Mammary Tissue	RP4-717I23.3	0.30	0.32	enet	17	0.33	1.4e-17	-9.1	9.1	6.0e-20	-0.81	1.00	0.00	FALSE
29	GTEx	Breast Mammary Tissue (Male)	RP4-717I23.3	0.29	0.23	lasso	8	0.21	1.5e-05	-9.1	9.2	4.0e-20	-0.79	0.38	0.09	FALSE
30	GTEx	Breast Mammary Tissue (Female)	RP4-717I23.3	0.19	0.20	lasso	13	0.19	2.1e-06	-9.1	9.1	8.1e-20	-0.79	0.36	0.60	FALSE
31	GTEx	Cells EBV-transformed lymphocytes	RP4-717I23.3	0.32	0.36	lasso	10	0.36	9.8e-13	-9.1	9.4	5.2e-21	-0.81	0.97	0.03	FALSE
32	GTEx	Cells Transformed fibroblasts	TMED5	0.10	0.11	lasso	3	0.09	4.6e-07	-9.4	9.4	8.0e-21	-0.84	0.83	0.17	FALSE
33	GTEx	Cells Transformed fibroblasts	DR1	0.18	0.21	enet	18	0.24	6.0e-18	-9.1	-9.9	2.5e-23	0.88	0.52	0.48	FALSE
34	GTEx	Cells Transformed fibroblasts	RP4-717I23.3	0.25	0.30	lasso	3	0.33	3.8e-25	-9.0	9.2	3.8e-20	-0.79	1.00	0.00	FALSE
35	GTEx	Colon Sigmoid	DR1	0.36	0.08	enet	46	0.17	1.7e-06	-9.1	-6.7	1.7e-11	0.73	0.17	0.78	FALSE
36	GTEx	Colon Sigmoid	RP4-717I23.3	0.28	0.30	lasso	8	0.33	2.4e-12	-9.1	10.1	5.1e-24	-0.91	0.03	0.97	FALSE
37	GTEx	Colon Transverse	DR1	0.14	0.14	lasso	5	0.10	1.7e-05	-9.1	-9.3	1.2e-20	0.82	0.30	0.68	FALSE
38	GTEx	Colon Transverse	CCDC18	0.10	0.04	enet	11	0.04	8.0e-03	-4.1	7.2	7.4e-13	-0.69	0.08	0.86	FALSE
39	GTEx	Colon Transverse	RP4-717I23.3	0.25	0.28	lasso	5	0.23	2.0e-11	-9.1	9.1	1.2e-19	-0.79	0.96	0.04	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	RP4-717I23.3	0.31	0.26	lasso	17	0.30	1.4e-11	-9.1	9.4	6.2e-21	-0.78	0.82	0.18	FALSE
41	GTEx	Esophagus Mucosa	CDC7	0.31	0.36	lasso	3	0.36	5.4e-25	-5.7	5.7	1.1e-08	0.03	0.03	0.97	FALSE
42	GTEx	Esophagus Mucosa	RP4-717I23.3	0.23	0.27	lasso	2	0.29	1.5e-19	-9.1	9.3	1.7e-20	-0.77	1.00	0.00	FALSE
43	GTEx	Esophagus Muscularis	DR1	0.12	0.06	lasso	7	0.07	6.6e-05	-9.2	-9.7	3.4e-22	0.89	0.01	0.98	FALSE
44	GTEx	Esophagus Muscularis	CCDC18	0.06	0.05	lasso	4	0.04	2.8e-03	-7.6	8.7	3.8e-18	-0.65	0.13	0.77	FALSE
45	GTEx	Esophagus Muscularis	RP4-717I23.3	0.31	0.38	lasso	5	0.42	2.0e-27	-9.1	10.0	1.8e-23	-0.86	1.00	0.00	FALSE
46	GTEx	Heart Atrial Appendage	DR1	0.10	0.06	lasso	4	0.05	2.8e-03	-10.6	-9.5	2.9e-21	0.91	0.01	0.98	FALSE
47	GTEx	Heart Atrial Appendage	RP4-717I23.3	0.30	0.25	lasso	6	0.27	1.3e-12	-9.1	9.2	2.2e-20	-0.78	1.00	0.00	FALSE
48	GTEx	Heart Left Ventricle	RP4-717I23.3	0.20	0.25	lasso	5	0.26	3.1e-14	-9.1	9.1	1.1e-19	-0.79	1.00	0.00	FALSE
49	GTEx	Liver	RP4-717I23.3	0.22	0.21	lasso	8	0.16	3.6e-05	-9.0	9.0	2.7e-19	-0.78	0.63	0.04	FALSE
50	GTEx	Lung	DR1	0.07	0.07	lasso	4	0.06	2.4e-05	-9.1	-9.8	1.2e-22	0.81	0.21	0.78	FALSE
51	GTEx	Lung	RP4-717I23.3	0.38	0.36	lasso	9	0.36	3.9e-29	-9.1	9.2	5.8e-20	-0.80	1.00	0.00	FALSE
52	GTEx	Muscle Skeletal	RP4-717I23.3	0.17	0.19	enet	25	0.18	3.3e-17	-9.1	8.7	3.1e-18	-0.76	1.00	0.00	FALSE
53	GTEx	Nerve Tibial	DR1	0.10	0.08	lasso	4	0.07	8.8e-06	-9.1	-8.9	7.4e-19	0.80	0.17	0.82	FALSE
54	GTEx	Nerve Tibial	CCDC18	0.06	0.04	lasso	11	0.04	7.2e-04	-10.6	9.8	1.8e-22	-0.88	0.02	0.96	FALSE
55	GTEx	Nerve Tibial	RP4-717I23.3	0.43	0.46	enet	39	0.54	1.0e-44	-9.1	9.7	2.4e-22	-0.85	1.00	0.00	FALSE
56	GTEx	Ovary	RP4-717I23.3	0.44	0.43	lasso	7	0.42	1.5e-11	-9.1	9.2	4.8e-20	-0.78	0.97	0.03	FALSE
57	GTEx	Pancreas	RP4-717I23.3	0.28	0.32	lasso	8	0.32	4.0e-14	-9.1	9.2	4.4e-20	-0.79	0.99	0.01	FALSE
58	GTEx	Pituitary	RP4-717I23.3	0.53	0.44	lasso	11	0.47	1.8e-13	-9.0	9.6	6.0e-22	-0.83	0.71	0.29	FALSE
59	GTEx	Prostate	RP4-717I23.3	0.46	0.46	lasso	10	0.45	1.1e-12	-9.1	9.2	3.6e-20	-0.77	0.82	0.18	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	CDC7	0.14	0.16	lasso	3	0.16	7.9e-09	-5.7	5.6	2.0e-08	0.03	0.03	0.97	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	RP4-717I23.3	0.40	0.41	lasso	9	0.38	3.7e-22	-9.1	9.0	2.0e-19	-0.77	1.00	0.00	FALSE
62	GTEx	Skin Sun Exposed Lower leg	CDC7	0.31	0.27	enet	36	0.26	1.9e-21	-5.7	5.7	1.3e-08	0.01	0.03	0.97	FALSE
63	GTEx	Skin Sun Exposed Lower leg	RP4-717I23.3	0.20	0.28	lasso	13	0.30	1.5e-25	-9.1	8.8	1.2e-18	-0.79	1.00	0.00	FALSE
64	GTEx	Spleen	CCDC18	0.29	0.07	lasso	10	0.15	9.2e-05	-9.5	9.5	1.8e-21	-0.86	0.02	0.95	FALSE
65	GTEx	Spleen	RP4-717I23.3	0.39	0.46	enet	22	0.48	5.3e-14	-9.0	9.2	2.9e-20	-0.79	0.96	0.04	FALSE
66	GTEx	Stomach	RP4-717I23.3	0.33	0.35	lasso	8	0.38	2.5e-19	-9.0	9.8	6.5e-23	-0.83	0.99	0.01	FALSE
67	GTEx	Testis	CDC7	0.23	0.06	lasso	3	0.05	4.3e-03	-5.7	-6.5	9.0e-11	-0.03	0.03	0.88	TRUE
68	GTEx	Testis	TMED5	0.27	0.31	lasso	5	0.30	6.9e-14	-9.5	9.7	3.0e-22	-0.83	0.93	0.07	FALSE
69	GTEx	Testis	RP4-717I23.3	0.45	0.42	enet	48	0.48	9.8e-24	-9.1	8.5	1.4e-17	-0.83	0.98	0.02	FALSE
70	GTEx	Thyroid	DR1	0.09	0.01	enet	14	0.04	5.3e-04	-9.3	-6.4	1.6e-10	0.63	0.02	0.89	FALSE
71	GTEx	Thyroid	RP4-717I23.3	0.41	0.44	lasso	10	0.49	1.8e-42	-9.1	9.6	7.8e-22	-0.80	1.00	0.00	FALSE
72	GTEx	Uterus	RP4-717I23.3	0.23	0.16	enet	14	0.17	2.7e-04	-9.1	8.8	1.6e-18	-0.79	0.15	0.56	FALSE
73	GTEx	Vagina	CDC7	0.32	0.12	enet	18	0.17	8.8e-05	3.7	5.8	5.0e-09	-0.03	0.10	0.36	FALSE
74	GTEx	Vagina	RP4-717I23.3	0.26	0.13	lasso	7	0.09	3.8e-03	-9.1	9.5	2.5e-21	-0.80	0.16	0.38	FALSE
75	GTEx	Whole Blood	RP4-717I23.3	0.15	0.16	enet	29	0.19	2.3e-17	-9.0	7.3	2.6e-13	-0.61	1.00	0.00	FALSE
76	METSIM	Adipose	CCDC18	0.08	0.06	lasso	4	0.07	4.9e-10	-9.1	10.4	2.1e-25	-0.90	0.04	0.96	FALSE
77	METSIM	Adipose	DR1	0.04	0.04	lasso	3	0.04	1.0e-06	-9.0	-9.2	3.1e-20	0.79	0.31	0.69	FALSE
78	METSIM	Adipose	RP4-717I23.3	0.21	0.34	enet	34	0.34	3.0e-52	-9.0	9.2	2.4e-20	-0.80	1.00	0.00	FALSE
79	METSIM	Adipose	TMED5	0.05	0.07	lasso	17	0.06	2.4e-09	-9.1	9.1	7.0e-20	-0.79	0.84	0.16	FALSE
80	NTR	Blood	CCDC18	0.03	0.00	blup	317	0.01	1.1e-05	-10.6	10.4	3.4e-25	-0.75	0.00	0.99	TRUE
81	NTR	Blood	DR1	0.01	0.01	blup	304	0.01	6.5e-03	-7.7	-6.5	7.0e-11	0.59	0.21	0.20	FALSE
82	NTR	Blood	TMED5	0.01	0.01	blup	277	0.01	5.2e-04	-10.6	9.6	1.0e-21	-0.83	0.01	0.98	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	TMED5	0.11	0.10	enet	17	0.13	2.7e-16	-10.6	10.0	1.1e-23	-0.88	0.00	1.00	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	DR1	0.09	0.12	enet	20	0.16	1.2e-20	-9.1	-10.6	1.8e-26	0.86	0.44	0.56	TRUE
85	ROSMAP	Brain Pre-frontal Cortex	RP4-717I23.3	0.33	0.57	lasso	9	0.58	2.6e-92	-9.1	9.2	4.1e-20	-0.78	1.00	0.00	FALSE
86	YFS	Blood	DR1	0.11	0.17	lasso	17	0.19	2.0e-58	-9.3	-10.3	5.0e-25	0.93	0.44	0.56	FALSE
87	YFS	Blood	TMED5	0.14	0.19	lasso	16	0.22	1.1e-69	-9.1	10.5	5.4e-26	-0.87	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC7	0.13	0.15	blup	73	0.18	7.8e-15	-3.6	5.2	1.9e-07	0.00	0.16	0.84	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	DR1	0.04	0.04	lasso	3	0.04	1.5e-08	-9.3	-10.2	2.6e-24	0.89	0.02	0.98	FALSE
90	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDC7	0.15	0.14	lasso	3	0.11	6.0e-06	-5.7	5.7	9.6e-09	0.04	0.01	0.98	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC18	0.08	0.08	lasso	1	0.05	7.7e-04	-9.0	-9.0	1.5e-19	0.80	0.41	0.10	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	DR1	0.36	0.06	enet	9	0.06	2.2e-04	-10.6	-9.1	7.5e-20	0.90	0.00	0.99	FALSE
93	The Cancer Genome Atlas	Glioblastoma Multiforme	TMED5	0.08	0.05	blup	39	0.03	4.7e-02	-9.5	10.3	8.5e-25	-0.85	0.01	0.73	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC7	0.34	0.32	enet	12	0.32	3.8e-36	-5.7	5.5	4.4e-08	0.04	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DR1	0.03	0.03	lasso	1	0.03	3.2e-04	-10.6	-10.6	2.0e-26	1.00	0.00	0.97	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DR1	0.05	0.05	blup	29	0.06	4.1e-07	-9.6	-10.5	6.5e-26	0.91	0.01	0.98	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC18	0.03	0.03	blup	52	0.03	5.0e-04	-4.0	7.5	6.1e-14	-0.69	0.04	0.72	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	DR1	0.03	0.03	blup	29	0.03	1.1e-04	-9.3	-10.1	6.5e-24	0.85	0.03	0.95	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMED5	0.08	0.06	enet	12	0.07	3.5e-08	-9.5	7.4	1.1e-13	-0.78	0.33	0.67	FALSE
100	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FNBP1L	0.13	0.02	lasso	3	0.01	1.3e-01	-5.4	-5.5	4.3e-08	0.34	0.02	0.04	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	DR1	0.05	0.03	blup	29	0.03	1.3e-04	-10.6	-10.3	5.5e-25	0.95	0.00	0.98	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCDC18	0.06	0.01	blup	52	0.02	3.6e-03	-9.1	-5.7	1.1e-08	0.48	0.15	0.04	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC7	0.07	0.13	enet	8	0.11	3.7e-12	-5.7	5.2	1.7e-07	0.04	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DR1	0.03	0.02	blup	29	0.02	3.2e-03	-9.6	-9.9	3.0e-23	0.84	0.01	0.93	FALSE
105	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMED5	0.05	0.05	enet	11	0.04	9.7e-04	-7.7	7.7	1.3e-14	-0.56	0.04	0.68	FALSE
106	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DR1	0.09	0.09	lasso	2	0.07	4.7e-04	-9.3	-9.3	1.1e-20	0.78	0.01	0.78	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	DR1	0.10	0.09	blup	29	0.08	3.9e-09	-9.3	-9.7	2.1e-22	0.84	0.10	0.90	FALSE
108	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDC7	0.11	0.18	lasso	3	0.15	2.4e-09	-5.7	5.8	8.5e-09	0.03	0.01	0.99	FALSE
109	The Cancer Genome Atlas	Soft Tissue Sarcoma	DR1	0.10	0.03	lasso	4	0.06	3.2e-04	-9.0	-10.1	3.6e-24	0.88	0.11	0.56	FALSE
110	The Cancer Genome Atlas	Stomach Adenocarcinoma	DR1	0.07	0.05	enet	9	0.07	6.2e-06	-9.6	-10.3	4.9e-25	0.88	0.02	0.98	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMED5	0.05	0.06	lasso	2	0.05	1.4e-04	-10.1	10.1	8.9e-24	-0.75	0.01	0.98	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	DR1	0.16	0.18	blup	29	0.19	4.1e-18	-9.6	-9.9	3.9e-23	0.86	0.47	0.53	FALSE