Hub : Genes

FBXO34

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0160	1.2e-08	0.104	0.080	0.089	0.083	0.092	1.3e-12	5.1e-10	5.4e-11	2.6e-10	2.5e-11
2	GTEx	Skin Sun Exposed Lower leg	0.0530	0.0270	5.6e-03	-0.003	NA	-0.003	NA	-0.003	6.4e-01	NA	6.3e-01	NA	9.5e-01
3	GTEx	Thyroid	0.1160	0.0410	8.8e-07	0.087	NA	0.055	NA	0.100	3.2e-07	NA	4.8e-05	NA	4.3e-08
4	YFS	Blood	0.0406	0.0122	5.9e-14	0.046	0.043	0.037	0.044	0.048	7.8e-15	7.9e-14	3.4e-12	3.4e-14	2.2e-15
5	TCGA	Brain Lower Grade Glioma	0.0220	0.0130	2.9e-03	0.022	0.019	0.008	NA	0.011	1.4e-03	2.4e-03	3.5e-02	NA	1.7e-02
6	TCGA	Prostate Adenocarcinoma	0.1077	0.0378	2.3e-07	0.079	0.074	0.081	NA	0.084	1.1e-08	3.7e-08	7.4e-09	NA	4.4e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.1	3.2	0.5	0.3	1.1	-1.3	-0.3	1.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.0	-0.3	-0.6	0.2	0.5	-0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.4	0.4	-0.0
Depression (Nagel 2018)	0.6	0.8	1.7	-0.9	-0.9	-1.3	0.7	1.1	-0.3
Intelligence (Savage-Jansen 2018)	1.8	5.5	8.9	-2.5	-2.5	-3.0	2.5	2.3	0.3
Neuroticism (Nagel 2018)	0.4	1.0	2.0	0.9	1.0	1.4	-1.4	-0.6	0.3
Schizophrenia (2018)	0.8	1.7	4.3	-0.5	-0.6	-1.6	1.3	0.9	-2.1
Schizophrenia vs Biploar Disorder	0.5	0.6	3.4	0.2	-0.1	-0.4	0.2	0.1	-1.8
Worry (Nagel 2018)	2.1	4.4	7.1	2.3	2.0	2.5	-2.7	-1.8	0.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	0.6	0.4	0.7	-1.0	-0.6	0.7
Alzheimer’s Disease (in father)	0.5	0.6	2.5	0.1	-0.2	0.5	-0.6	0.4	1.6
Alzheimer’s Disease (including proxy)	1.0	1.4	4.4	0.7	0.1	1.3	-1.3	-0.2	2.1
Crohns Disease (2017)	0.8	1.7	3.0	1.1	1.6	1.3	-1.2	-1.7	-0.6
Irritable Bowel Disease (IBD)	0.8	1.9	3.0	1.1	1.5	1.7	-1.5	-1.7	-0.3
Ulcerative Colitis (UC)	0.4	0.7	1.7	0.5	0.6	1.3	-1.1	-0.7	0.4
Major Depression (MDD)	0.4	0.5	2.2	0.3	0.5	0.3	0.3	-0.1	-1.5
Reaction Time	1.0	2.0	3.6	-1.2	-1.8	-1.3	0.8	1.9	1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.6	-1.3	-1.3	-1.6	1.5	1.1	-0.7
Breast Cancer	0.0	0.1	0.1	-0.4	-0.2	-0.2	0.3	-0.1	-0.3
Ovarian Cancer	0.1	0.1	0.2	0.2	0.4	-0.0	0.1	-0.5	-0.3
Prostate Cancer	1.0	1.4	4.0	1.1	1.0	1.0	-0.5	-0.9	-2.0
Age at First Birth	1.7	2.5	6.6	-1.6	-1.6	-1.0	0.7	1.2	2.6
Bipolar Disorder (2011)	0.3	0.3	0.7	0.0	-0.5	-0.7	0.3	0.8	-0.5
Body Mass Index (BMI) (2010)	0.6	0.9	1.4	1.2	1.0	0.6	-1.0	-1.2	0.2
Coronary Artery Disease (CAD)	0.5	0.6	1.8	-0.4	-0.5	-0.6	0.8	0.4	-1.4
Crohns Disease (2012)	0.1	0.2	0.6	0.0	0.5	0.4	-0.3	-0.8	0.0
Mean Putamen Volume	0.8	0.9	3.6	0.6	0.6	-0.2	0.1	-0.9	-1.9
Fasting Glucose	0.5	0.6	2.3	-0.9	-0.6	-0.1	-0.2	0.1	1.5
HbA1C	0.1	0.1	0.5	-0.2	-0.2	-0.3	0.7	0.3	0.4
HDL Cholesterol	0.3	0.5	1.2	0.5	0.6	0.5	-0.7	-0.6	1.1
LDL Cholesterol	0.1	0.2	0.5	-0.6	-0.6	-0.0	0.3	0.2	0.7
Lupus	1.0	1.5	3.0	-0.9	-0.7	-1.2	1.6	1.0	-1.7
Neuroticism (2016)	1.3	1.8	3.9	1.4	1.0	1.8	-2.0	-0.6	0.8
Primary Biliary Cirrhosis	2.3	3.3	5.3	1.5	1.6	2.0	-2.3	-1.7	1.8
Rheumatoid Arthritis	0.9	1.2	3.9	0.3	0.1	1.2	-1.4	0.1	2.0
Schizophrenia (2014)	0.2	0.4	1.1	-0.0	-0.5	-1.1	0.4	0.6	-0.7
Triglycerides	0.1	0.2	0.5	-0.6	-0.4	-0.4	0.2	0.1	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	0.4	0.2	0.4	-0.6	-0.4	1.0
Ulcerative Colitis	0.5	0.7	1.6	0.7	0.4	1.1	-1.2	-0.5	0.5
Blood Eosinophil Count	9.0	69.0	95.5	-9.8	-9.4	-8.2	8.3	9.4	2.1
Blood Platelet Count	4.5	52.7	68.9	-8.0	-8.3	-6.6	6.0	8.3	6.0
Blood Red Count	1.3	12.8	15.6	-3.9	-4.0	-3.6	3.1	3.5	3.2
Blood White Count	4.0	29.4	43.4	-5.8	-5.0	-5.8	6.6	5.3	-3.6
Heel T-Score	0.2	1.5	2.6	-1.6	-1.5	-0.6	1.3	1.3	0.6
BMI	2.1	11.9	17.2	4.0	3.8	3.4	-3.1	-4.1	-1.7
Height	0.3	5.8	26.9	1.3	0.2	0.7	-2.4	0.1	5.2
Waist Hip Ratio (WHR)	0.3	1.5	8.4	0.7	0.3	-0.2	0.4	0.2	-2.9
Systolic Blood Pressure	0.8	3.8	7.4	-2.7	-2.0	-0.8	1.4	1.6	2.5
Smoking Status	0.5	1.2	3.6	-0.7	-0.8	-0.8	1.2	0.9	-1.9
Allergy or Eczema	0.4	1.0	1.5	-1.1	-1.2	-0.8	0.8	1.1	1.0
Cardiovascular Disease	0.2	0.7	1.3	0.8	0.7	1.1	-0.9	-1.1	0.3
Hypothyroidism (self reported)	3.7	8.6	10.8	-3.2	-3.0	-3.3	3.3	3.1	-1.0
Respiratory disease	0.0	0.1	0.4	0.1	-0.2	-0.2	0.1	0.2	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.7	-1.1	-1.3	-0.9	1.1	1.2	-0.0
Lung FEV1/FVC ratio	0.9	4.7	13.1	-2.0	-2.0	-1.7	0.7	1.9	3.6
Lung FVC	0.4	1.9	7.5	-0.6	-0.5	-1.0	1.4	0.4	-2.7
Neuroticism	0.7	1.6	3.1	0.9	0.9	1.4	-1.8	-0.4	1.5
Chronotype (morning person)	1.5	3.5	5.8	-1.8	-1.9	-2.4	2.1	1.8	-0.5
Hair Pigment	0.1	2.3	11.6	0.9	0.6	0.1	0.6	-1.0	-3.4
Tanning	0.4	5.2	9.6	2.0	2.4	2.6	-1.9	-3.1	-1.0
Hand grip strength (left)	0.2	0.5	1.0	-0.7	-0.2	-0.7	1.0	0.5	-0.9
Number of treatments/medications taken	0.8	1.4	2.6	1.6	0.8	1.0	-1.0	-1.0	-1.5
Average weekly spirits intake	2.0	2.5	3.3	1.8	1.6	1.7	-1.4	-1.8	-1.0
Sensitivity / hurt feelings	0.5	0.9	1.5	0.6	1.2	1.1	-1.1	-1.0	-0.5
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.7	-0.2	-0.4	-0.6	0.3	0.6	-1.3
Hearing difficulty/problems: Yes	0.5	0.7	1.2	-0.8	-1.1	-0.9	0.9	0.8	0.5
Relative age of first facial hair	0.7	1.4	2.7	-1.6	-1.0	-0.8	1.0	1.2	1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	5.7	-0.2	-0.5	-0.8	1.1	0.5	-2.4
Ever used hormone-replacement therapy (HRT)	2.8	3.6	5.4	-1.5	-1.5	-2.1	2.0	1.7	-2.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.2	0.0	-0.2	-0.1	-0.3	-0.4
Systolic blood pressure, automated reading	0.3	0.8	3.5	-0.9	-0.0	0.8	-0.4	-0.1	1.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.3	1.2	0.9	0.8	-1.0	-0.7	-0.8
Angina	0.2	0.3	0.7	-0.6	-0.3	-0.6	0.9	0.5	-0.1
Medication for hormone replacement therapy	3.3	3.6	10.4	-1.1	-0.9	-2.1	2.0	1.0	-3.2
Vitamin and mineral supplements	11.7	15.8	21.0	-4.6	-4.5	-3.9	4.3	4.5	0.3
Supplements: Zinc	0.0	0.0	0.1	-0.1	-0.3	-0.4	0.0	0.0	-0.1
Medication: Co-codamol	0.9	1.0	2.6	1.4	0.7	0.2	-0.6	-0.9	-1.6
Medication: Metformin	1.3	1.8	2.5	-1.2	-1.5	-1.2	1.6	1.3	-1.2
Diabetes (father)	0.2	0.2	1.1	0.5	0.0	0.1	-0.0	0.1	-1.0
Diabetes (mother)	0.5	0.6	1.1	0.9	0.7	0.6	-0.7	-1.0	-0.7
Severe depression (siblings)	1.8	2.0	3.3	-0.9	-1.2	-1.8	1.4	1.5	-1.5
Pack years adult smoking proportion	5.7	8.7	11.9	-3.1	-3.2	-3.2	3.1	3.5	-0.4
Impedance of leg (right)	0.2	1.1	1.7	-0.8	-1.2	-1.1	0.6	1.3	1.1
Leg fat-free mass (left)	1.0	5.2	7.7	2.7	2.5	2.2	-2.3	-2.8	-0.1
Trunk fat percentage	0.7	2.8	4.4	2.1	1.8	1.1	-1.7	-2.1	-1.0
Hand grip strength (right)	0.1	0.3	0.9	-1.0	-0.4	-0.2	0.5	0.5	0.5
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.0	0.8	0.4	-0.6	-0.6	-1.2
Current tobacco smoking	1.5	2.5	3.4	-1.5	-1.5	-1.7	1.8	1.7	-1.0
Average weekly fortified wine intake	0.3	0.4	1.4	-0.4	-0.5	-0.3	0.2	0.6	1.2
Maternal smoking around birth	1.0	1.5	2.7	-0.9	-1.7	-1.4	1.2	1.3	-0.4
Fed-up feelings	0.9	1.7	3.5	1.7	1.0	1.4	-1.9	-0.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	-0.5	-0.8	-0.9	0.7	0.8	-1.2
Relative age voice broke	1.2	1.9	4.2	-1.8	-1.2	-0.4	0.7	1.4	2.0
Taking other prescription medications	0.2	0.3	1.6	0.2	-0.4	-0.2	0.3	0.2	-1.3
Age when periods started (menarche)	0.9	2.1	4.1	-1.7	-1.7	-0.8	0.9	2.0	1.0
Bilateral oophorectomy (both ovaries removed)	2.4	2.7	4.3	-1.6	-1.5	-2.1	2.1	1.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	4.2	-2.0	-1.8	-1.6	1.8	1.7	-0.1
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	5.2	-1.6	-2.3	-2.2	2.0	2.3	-0.2
Qualifications: CSEs or equivalent	1.0	1.3	1.7	1.2	1.2	1.2	-0.9	-1.3	-1.1
Serious illness, injury or assault to yourself	1.1	1.3	6.2	0.7	0.7	0.5	-0.1	-0.5	-2.5
High blood pressure	0.1	0.3	0.7	0.4	0.5	0.3	-0.2	-0.8	-0.6
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.5	-1.9	-1.9	-1.5	1.3	1.7	1.0
Multivitamins +/- minerals	6.7	8.6	12.3	3.5	3.0	3.0	-3.3	-3.2	0.6
Stomach or abdominal pain in last month	0.8	1.0	2.8	1.0	1.1	0.3	-0.5	-0.8	-1.7
Supplements: Glucosamine	7.8	10.2	15.7	4.0	3.5	3.3	-3.6	-3.0	-1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.9	1.4	0.9	0.6	-1.1	-0.9	-0.2
Medication: Atenolol	0.1	0.1	0.1	-0.4	-0.1	-0.3	0.3	-0.3	0.3
Medication: Levothyroxine sodium	2.2	3.8	4.8	-2.1	-2.1	-2.2	2.1	2.1	-0.5
Sitting height	0.4	3.1	4.2	1.9	1.7	1.3	-2.0	-1.8	1.6
Chronic bronchitis/emphysema (father)	2.0	2.3	3.3	1.1	1.6	1.8	-1.6	-1.5	1.4
High blood pressure (mother)	1.7	2.4	4.2	1.6	1.9	1.0	-0.9	-2.1	-1.4
Body mass index (BMI)	1.6	6.7	10.7	2.9	2.8	2.3	-2.1	-3.3	-1.9
Impedance of leg (left)	0.2	0.9	1.4	-0.8	-1.0	-1.2	0.5	1.1	0.8
Leg predicted mass (left)	1.0	5.1	7.5	2.7	2.5	2.1	-2.3	-2.7	-0.1
Trunk fat mass	1.0	4.4	6.8	2.6	2.3	1.6	-2.2	-2.6	-0.7
Waist circumference	0.8	2.8	4.1	2.0	1.8	1.4	-1.4	-2.0	-1.3
Number of incorrect matches in round	3.1	5.1	6.4	2.2	2.5	2.5	-2.4	-2.1	1.7
Past tobacco smoking	0.4	0.7	3.6	-0.1	0.2	0.4	-0.4	-0.2	1.9
Alcohol usually taken with meals	0.1	0.2	0.4	-0.3	-0.1	-0.6	0.7	0.6	-0.0
Nervous feelings	1.6	3.0	6.2	1.5	1.5	2.1	-2.5	-1.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	0.4	0.5	0.4	-0.3	-0.4	-1.6
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.2	-0.7	-0.4	-0.0	0.6	0.1
Hair/balding pattern: Pattern 2	2.9	3.7	5.4	1.9	2.3	2.1	-1.9	-2.2	-0.4
Had menopause	0.3	0.4	0.9	-0.6	-0.6	-0.9	0.3	0.8	-0.2
Had other major operations	0.6	0.8	1.9	-0.6	-0.5	-0.7	1.0	0.7	-1.4
Forced vital capacity (FVC)	0.4	1.7	2.4	1.4	1.4	1.2	-1.4	-1.6	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.0	-1.4	-1.2	-1.2	1.3	0.9	-0.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	4.6	-0.1	-0.5	-0.6	0.8	0.6	-2.1
Qualifications: None of the above	0.6	1.4	2.7	1.5	0.9	1.0	-1.6	-0.8	0.7
Financial difficulties in last 2 years	0.1	0.1	0.2	0.4	0.3	0.1	-0.2	-0.3	-0.3
Mouth/teeth dental problems	0.4	0.7	1.6	0.8	0.6	0.7	-0.8	-0.6	1.3
Heart attack	0.2	0.2	0.5	-0.5	-0.2	-0.7	0.6	0.5	-0.3
Allergy	1.3	2.9	4.2	1.8	2.1	1.7	-1.4	-1.9	-1.2
Pain all over the body in last month	4.2	4.5	5.9	2.4	2.4	2.1	-2.0	-2.4	-1.1
Diabetes (self-reported)	1.6	2.5	3.8	-1.7	-1.9	-1.5	1.6	1.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.2	-0.3	0.0	1.0	-0.6	-0.1	1.5
Medication: Ramipril	2.5	3.2	4.6	-2.0	-1.8	-1.5	2.1	1.9	-1.4
Medication: Simvastatin	0.1	0.2	0.4	0.6	0.2	-0.0	-0.2	-0.5	-0.6
Fluid intelligence score	0.6	1.3	1.7	-1.3	-1.3	-1.2	1.3	1.1	-0.0
Illnesses of siblings	0.2	0.3	1.0	0.6	0.5	0.3	-0.2	-0.5	-1.0
Neuroticism score	0.7	1.5	3.0	1.1	1.3	1.5	-1.7	-0.8	0.1
Weight	2.0	9.6	14.1	3.7	3.4	2.9	-3.1	-3.8	-0.5
Impedance of arm (right)	1.5	7.1	11.1	-2.8	-3.0	-2.9	2.1	3.3	1.4
Arm fat percentage (right)	0.8	3.0	4.5	2.1	1.8	1.3	-1.5	-2.1	-1.3
Trunk fat-free mass	1.3	7.6	9.5	3.1	2.8	3.0	-2.9	-3.1	1.1
Hip circumference	0.8	3.4	5.5	2.0	1.9	1.8	-1.9	-2.3	0.4
Time employed in main current job	3.7	4.3	6.4	1.9	2.0	2.5	-2.5	-2.0	1.2
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.1	0.3	-0.6	0.3	-0.7	-0.6
Father’s age at death	1.1	1.5	6.0	-0.1	0.4	1.3	-1.1	-0.4	2.4
Worrier / anxious feelings	1.1	2.0	3.2	1.2	1.4	1.7	-1.8	-1.4	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	-0.6	-1.1	-0.9	0.5	0.9	-0.5
Falls in the last year	1.1	1.5	6.6	0.9	1.0	-0.2	0.0	-0.9	-2.6
Hair/balding pattern: Pattern 3	0.0	0.1	0.3	0.0	-0.2	-0.1	0.0	0.6	-0.2
Number of live births	2.0	2.9	4.1	-1.2	-1.6	-1.8	2.0	1.8	-1.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	0.6	0.8	0.4	-0.8	-1.0	1.0
Pulse rate	2.4	4.1	6.8	1.8	2.6	1.4	-1.2	-2.4	-2.2
Happiness	0.1	0.1	0.2	0.5	0.3	0.2	-0.4	-0.1	-0.4
Noisy workplace	1.2	1.4	7.3	0.3	-0.1	-0.6	0.8	0.1	-2.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.8	-1.3	-1.3	-0.8	1.3	1.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.6	0.9	0.6	-0.1	-0.0	-0.8	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.1	8.9	-0.4	-0.6	-1.0	1.3	0.8	-3.0
Asthma	0.7	1.4	1.9	-1.3	-1.2	-1.3	1.4	1.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	5.4	2.3	1.6	2.1	-2.3	-1.9	1.1
Medication: Cholesterol lowering	0.9	1.3	5.2	-0.3	-0.4	-1.0	1.2	0.3	-2.3
Depression (self-reported)	0.5	0.6	1.6	1.2	0.6	0.4	-0.9	-0.7	0.1
Medication: Lansoprazole	0.6	0.6	0.9	0.9	0.8	0.6	-0.9	-1.0	-0.4
Prospective memory result	0.8	1.0	2.6	0.1	0.5	1.6	-1.0	-0.3	1.5
Lung cancer (father)	1.3	1.5	2.7	-1.2	-1.4	-1.6	1.3	1.2	0.1
Illnesses of mother	1.6	2.0	3.0	-1.4	-1.5	-1.5	1.4	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.0	1.3	1.5	1.3	-1.7	-1.6	1.4
Pulse wave Arterial Stiffness index	2.0	2.3	4.2	1.6	1.5	2.0	-1.6	-1.5	-0.5
Impedance of arm (left)	1.4	6.6	10.0	-2.7	-2.9	-2.9	1.9	3.2	1.5
Arm fat mass (right)	1.5	6.2	9.7	3.0	2.7	2.0	-2.3	-3.1	-1.2
Trunk predicted mass	1.3	7.7	9.6	3.1	2.9	3.0	-2.9	-3.1	1.2
Standing height	0.5	4.6	11.1	2.0	1.5	1.5	-2.6	-1.3	3.3
Length of working week for main job	0.6	0.6	2.4	0.6	0.4	-0.4	0.3	-0.8	-1.6
Exposure to tobacco smoke at home	1.0	1.2	3.7	0.0	-1.0	-0.8	0.9	0.9	-1.9
Breastfed as a baby	1.8	2.3	3.8	1.5	0.8	1.5	-1.9	-1.0	2.0
Tense / ‘highly strung’	4.1	6.7	10.1	2.4	2.7	2.9	-3.2	-2.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	4.1	1.2	1.1	0.5	-0.6	-0.6	-2.0
Hair/balding pattern: Pattern 4	2.1	5.2	7.4	-2.5	-2.4	-2.7	2.2	2.4	0.6
Birth weight of first child	1.7	3.0	4.6	1.6	1.8	1.8	-2.0	-2.1	0.9
Peak expiratory flow (PEF)	0.3	0.7	4.0	0.0	0.4	0.1	-0.3	-0.4	2.0
Pulse wave reflection index	0.4	0.5	1.3	0.3	0.1	1.1	-0.8	-0.2	1.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.0	1.4	0.6	0.3	-0.7	-0.9	-1.4
Loud music exposure frequency	0.7	0.7	1.4	-0.5	-1.0	-1.2	0.9	0.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.1	-1.3	-1.4	-1.0	1.4	1.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.1	0.1	-0.0	-0.4	0.0	0.6
Blood clot in the leg (DVT)	1.9	2.4	4.1	-1.1	-1.2	-2.0	1.8	1.3	-1.6
Medication: Paracetamol	0.3	0.5	1.1	1.1	0.4	0.7	-0.7	-0.6	-0.7
Headache pain in last month	1.1	1.8	2.6	1.4	1.6	1.0	-1.1	-1.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.6	-0.5	-0.2	0.1	-0.1	0.5	1.6
Glaucoma (self-reported)	0.4	0.5	2.0	-0.0	0.1	0.8	-0.5	0.2	1.4
Gout (self-reported)	1.5	2.1	3.6	-1.5	-1.4	-1.9	1.7	1.0	-0.9
Hypothyroidism/myxoedema (self-reported)	4.7	9.2	11.9	-3.3	-3.1	-3.5	3.4	3.3	-1.1
Medication: Amlodipine	0.4	0.5	0.7	0.8	0.7	0.8	-0.8	-0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.4	0.4	0.5	-0.3	-0.4	-0.4
Birth weight	0.1	0.3	0.9	-1.0	-0.2	-0.1	0.5	0.5	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.2	0.5	0.5	0.0	-0.6	-0.6
High blood pressure (siblings)	0.2	0.2	0.8	-0.7	-0.2	0.1	0.1	0.1	0.9
Forced vital capacity (FVC), Best measure	0.8	2.8	3.6	1.9	1.8	1.7	-1.9	-1.9	0.6
Body fat percentage	1.1	4.2	6.4	2.5	2.2	1.4	-1.9	-2.5	-1.4
Leg fat percentage (right)	1.6	5.9	9.0	3.0	2.5	1.9	-2.0	-2.9	-1.9
Arm fat-free mass (right)	1.8	9.3	12.9	3.6	3.2	3.1	-3.1	-3.6	0.2
Exposure to tobacco smoke outside home	0.0	0.1	0.2	0.2	-0.1	-0.3	-0.4	0.2	0.2
Comparative body size at age 10	0.3	0.7	1.3	1.1	0.9	0.5	-0.8	-1.2	-0.2
Number of full brothers	0.1	0.1	0.3	0.2	-0.5	-0.1	0.0	0.5	0.3
Worry too long after embarrassment	0.4	0.7	1.5	0.7	1.2	0.8	-0.9	-0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.7	0.2	-0.0	-0.2	0.3	0.5	-1.6
Wheeze or whistling in the chest in last year	1.2	2.1	3.4	-1.2	-1.1	-1.8	1.9	1.2	-1.3
Number of children fathered	2.3	2.5	10.0	-0.1	-0.3	-1.6	1.6	0.4	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.8	1.3	1.2	1.1	-1.3	-1.2	0.8
Age at first live birth	0.8	1.4	2.2	-1.2	-1.5	-1.2	0.8	1.2	1.2
Pulse wave peak to peak time	1.7	2.0	3.5	-1.4	-1.4	-1.9	1.4	1.4	0.8
Health satisfaction	2.4	3.2	9.9	2.0	1.4	0.9	-0.7	-1.3	-3.1
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.0	-0.4	-0.4	0.5	0.4	-0.9
Qualifications: College or University degree	1.2	3.9	5.7	-2.1	-2.0	-2.0	2.4	2.3	-0.1
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.9	-0.5	-0.7	0.8	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	2.7	3.3	6.4	-1.3	-1.6	-1.6	1.8	1.7	-2.5
Emphysema/chronic bronchitis	1.8	2.0	3.3	-1.4	-1.7	-1.4	1.3	1.8	0.4
Medication for pain relief, constipation, heartburn	1.1	1.9	3.5	-1.9	-1.2	-1.5	1.4	1.4	0.4
Neck or shoulder pain in last month	0.5	0.7	2.2	0.6	0.8	0.5	-0.4	-0.7	-1.5
Medication: Blood pressure	0.3	0.5	2.4	0.2	0.3	0.3	0.1	-0.5	-1.6
Angina (self-reported)	0.3	0.4	0.9	-0.7	-0.3	-0.6	0.9	0.4	-0.4
Migraine (self-reported)	1.0	1.2	6.4	0.5	0.2	-0.7	0.3	-0.3	-2.5
Medication: Ibuprofen	2.4	2.8	5.6	2.4	1.5	1.6	-1.9	-1.6	0.4
Medication: Allopurinol	0.4	0.6	1.0	-0.8	-0.9	-0.8	1.0	0.6	-0.2
Medication: Omeprazole	1.8	2.1	3.5	1.7	1.2	1.8	-1.9	-0.8	0.9
Medication: Seretide 50 evohaler	2.0	2.3	3.3	-1.2	-1.8	-1.8	1.7	1.5	-0.6
Mean time to correctly identify matches	1.5	2.8	5.1	-1.6	-2.1	-1.6	1.1	2.3	0.7
Heart disease (mother)	0.6	0.7	1.1	0.9	1.0	0.9	-0.8	-1.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	-0.7	0.1	-0.4	0.6	-0.1	-1.1
Whole body fat mass	1.4	5.6	9.0	2.9	2.6	1.9	-2.3	-3.0	-1.0
Leg fat mass (right)	2.0	7.7	11.8	3.4	3.0	2.4	-2.6	-3.4	-1.4
Arm predicted mass (right)	1.7	8.5	11.9	3.4	3.1	3.0	-3.0	-3.4	0.4
Pulse rate, automated reading	4.1	13.3	19.8	3.7	4.4	3.8	-3.1	-4.5	-1.7
Alcohol intake frequency.	0.4	1.0	4.7	0.1	-0.0	-0.9	0.7	0.1	-2.2
Comparative height size at age 10	0.5	2.9	4.7	2.2	1.7	1.2	-2.2	-1.5	1.1
Number of full sisters	2.2	2.7	4.1	-1.6	-1.8	-1.8	1.7	2.0	-0.8
Suffer from ‘nerves’	1.9	3.0	5.2	1.7	1.7	2.1	-2.3	-1.4	0.8
Overall health rating	1.7	3.7	5.2	2.1	2.1	1.2	-1.4	-2.2	-2.3
Chest pain or discomfort	1.9	2.8	5.3	-1.1	-1.6	-2.3	1.7	1.8	-1.2
Had major operations	0.5	0.6	1.1	1.0	0.6	0.1	-0.4	-1.0	-0.9
Age at last live birth	0.3	0.5	1.0	-0.4	-0.8	-0.8	0.3	1.0	0.6
Family relationship satisfaction	0.6	0.7	2.8	-0.2	-0.6	-0.5	0.5	0.9	-1.7
Leg pain on walking	3.2	4.0	5.7	2.4	2.1	1.8	-1.5	-1.6	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.4	-0.3	-0.7	0.6	0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	0.1	0.1	0.7	-0.9	-0.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.9	-0.8	-0.4	-0.2	0.5	0.4	1.4
Medication: Aspirin	0.2	0.3	0.9	0.6	0.3	0.1	-0.2	-0.4	-0.9
Supplements: Vitamin C	2.7	3.2	4.9	1.7	2.0	1.9	-1.9	-2.2	0.1
Knee pain experienced in last month	8.3	12.9	15.7	4.0	4.0	3.9	-3.7	-3.8	-1.6
Hypertension (Self-reported)	0.0	0.1	0.3	-0.1	0.2	-0.0	0.1	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.3	0.1	0.7	-0.4	-0.2	0.6
Illnesses of father: Heart disease	0.7	1.0	2.1	-1.0	-0.8	-1.5	1.0	0.8	0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.4	-0.7	-0.3	0.5	0.8	0.8
Smoking status: Previous	0.3	0.4	2.3	0.5	0.1	-0.1	0.1	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.2	0.7	0.9	0.8	-1.1	-0.7	1.5
Whole body fat-free mass	1.3	7.5	10.2	3.2	2.9	2.8	-2.8	-3.2	0.4
Leg fat-free mass (right)	1.0	5.2	7.8	2.7	2.5	2.1	-2.3	-2.8	-0.1
Arm fat percentage (left)	0.7	2.8	4.2	2.0	1.7	1.2	-1.5	-2.0	-1.4
Average weekly red wine intake	0.0	0.0	0.1	-0.0	0.3	0.1	0.1	-0.3	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.6	0.2	0.3	-0.5	-0.2	0.8
Mood swings	1.0	1.8	2.7	1.2	1.6	1.6	-1.7	-1.2	-0.3
Loneliness, isolation	0.7	0.9	2.4	0.6	0.9	1.6	-1.2	-0.7	-0.1
Long-standing illness, disability or infirmity	0.9	1.3	1.8	-1.3	-1.2	-1.1	1.3	1.2	-0.6
Ever had bowel cancer screening	0.8	1.0	1.7	-0.9	-1.2	-0.9	0.8	1.3	-0.7
Diabetes diagnosed by doctor	2.3	3.7	5.8	-1.9	-2.4	-2.0	1.9	2.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.2	-0.9	-1.3	-1.8	1.6	1.3	-1.3
Friendships satisfaction	0.2	0.3	1.2	0.5	0.0	0.3	-0.2	-0.0	-1.1
Qualifications: nursing, teaching	3.0	4.6	6.9	-2.2	-2.1	-2.3	2.6	2.0	-1.5
Commuting to job workplace: Walk	1.0	1.1	5.0	-1.1	-0.4	-0.1	0.1	0.4	2.2
Eye problems/disorders: Cataract	0.6	0.7	1.2	-0.8	-1.1	-1.0	0.8	0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.5	3.1	1.6	1.8	1.7	-1.8	-1.8	-0.1
Medication for cholesterol	0.3	0.4	0.9	0.3	0.5	0.9	-0.7	-0.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.1	-0.2	0.0	0.4	-0.6	-0.4	1.8
Back pain experienced in last month	1.0	1.5	3.5	1.9	1.0	1.0	-1.3	-1.2	-0.6
Mineral and other dietary supplements	6.5	8.8	13.4	-3.7	-2.7	-3.0	3.6	2.9	-1.3
Breast cancer (self-reported)	0.4	0.5	1.5	-0.5	-0.0	-0.7	0.9	0.2	-1.2
Asthma (self-reported)	0.9	1.8	2.4	-1.6	-1.5	-1.4	1.6	1.4	-0.0
Osteoporosis (self-reported)	0.6	0.7	1.3	-0.7	-0.9	-1.1	0.8	0.9	0.4
Osteoarthritis (self-reported)	0.7	0.9	1.8	1.3	0.9	0.8	-0.9	-1.0	-0.7
Medication: Aspirin	0.3	0.4	2.1	0.5	0.3	-0.2	0.1	-0.3	-1.5
Medication: Gliclazide	0.4	0.4	0.9	0.5	0.3	0.8	-0.7	-0.4	1.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.2	-0.3	-0.5	-0.3	0.5	0.5	-0.3
Smoking status: Current	1.1	1.7	2.2	-1.3	-1.3	-1.4	1.5	1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.2	-0.1	-0.4	-0.3	-0.1	0.3	1.5
Whole body water mass	1.3	7.4	10.1	3.2	2.9	2.8	-2.8	-3.1	0.4
Leg predicted mass (right)	0.9	4.7	7.2	2.5	2.4	2.0	-2.2	-2.7	0.0
Arm fat mass (left)	1.5	6.2	9.7	3.0	2.7	2.1	-2.4	-3.1	-1.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.6	0.1	-0.3	-0.2	0.2	0.0	-0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-0.4	-0.7	-1.1	0.9	0.6	0.1
Miserableness	0.9	1.6	2.7	-1.0	-1.2	-1.3	1.0	1.6	-1.3
Guilty feelings	1.3	2.0	3.5	1.5	1.3	1.7	-1.9	-0.8	1.0
Wears glasses or contact lenses	1.6	1.8	3.2	-1.5	-1.8	-0.8	0.9	1.6	1.1
Ever taken oral contraceptive pill	2.2	2.5	3.8	-1.2	-1.2	-1.7	1.9	1.4	-1.9
Hearing aid user	1.0	1.2	2.6	-0.3	-0.6	-1.6	1.3	0.6	-1.4
Mother’s age at death	0.2	0.2	0.4	0.5	0.5	0.6	-0.5	-0.1	0.6
Financial situation satisfaction	0.4	0.4	1.5	0.7	0.5	0.5	-0.4	0.0	-1.2
Tinnitus: Yes, now most or all of the time	2.9	3.4	5.4	-1.9	-1.8	-2.1	2.3	1.8	-0.7
Commuting to job workplace: Public transport	0.8	1.0	1.5	-1.1	-1.0	-0.6	1.2	1.1	0.5
Eye problems/disorders: Glaucoma	0.4	0.4	2.0	-0.3	-0.1	0.7	-0.2	0.2	1.4
Medication: Blood pressure	0.2	0.3	0.5	-0.5	-0.7	-0.5	0.3	0.6	0.6
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.1	1.8	1.0	1.5	-1.2	-0.7	-1.5
Supplements: Fish oil (including cod liver oil)	8.0	10.5	15.0	3.5	2.8	3.5	-3.9	-3.2	2.3
High cholesterol (Self-reported)	0.7	1.3	2.5	1.4	1.0	0.8	-0.8	-1.1	-1.6
Medication: Bendroflumethiazide	0.8	1.2	1.6	1.1	0.7	1.1	-1.3	-1.2	1.1
Medication: Paracetamol	1.7	2.6	4.8	2.2	1.4	1.3	-1.4	-1.4	-1.8
Medication: Lisinopril	0.7	0.9	2.2	-0.4	-0.7	-1.0	1.0	0.8	-1.5
Medication: Atorvastatin	0.5	0.6	2.3	-0.1	-0.2	-0.7	0.8	0.2	-1.5
Illnesses of father: High blood pressure	0.5	0.6	1.1	0.5	1.0	0.7	-0.6	-1.1	-0.5
Alcohol drinker status: Never	2.0	2.4	3.8	-1.7	-1.3	-1.6	1.9	1.7	-0.8
Ever smoked	0.8	1.3	2.9	1.1	1.2	1.0	-0.7	-1.0	-1.7
Basal metabolic rate	1.5	8.3	11.7	3.4	3.1	2.8	-3.0	-3.4	0.2
Leg fat percentage (left)	1.8	6.6	10.0	3.0	2.7	1.9	-2.0	-3.2	-2.3
Arm fat-free mass (left)	1.9	9.8	14.1	3.7	3.4	3.1	-3.2	-3.8	0.1
Number of operations (self-reported)	1.1	1.6	7.8	-0.0	-0.3	-0.8	1.1	0.2	-2.8
Average weekly beer plus cider intake	0.8	1.2	1.9	1.1	1.2	1.4	-1.2	-1.1	0.4
Irritability	0.0	0.1	0.1	0.1	-0.1	0.3	-0.3	0.2	-0.3
Risk taking	0.8	1.2	3.4	1.3	0.9	0.6	-0.6	-0.8	-1.8
Ever had prostate specific antigen (PSA) test	9.1	10.5	13.9	3.7	3.1	3.5	-3.7	-3.4	1.3
Fractured/broken bones in last 5 years	1.8	2.3	3.2	1.5	1.7	1.4	-1.2	-1.8	-1.5
Age started oral contraceptive pill	0.2	0.2	0.4	0.4	0.2	0.6	-0.5	0.1	0.5
Diastolic blood pressure, automated reading	2.1	6.6	11.1	2.0	2.7	2.9	-2.7	-3.3	1.3
Ever depressed for a whole week	0.4	0.5	1.7	-0.1	-0.6	-0.6	0.8	0.5	-1.3
Unable to work because of sickness or disability	0.7	0.9	2.5	-0.7	-0.8	-0.6	0.8	0.7	-1.6
Commuting to job workplace: Cycle	0.6	0.8	1.7	-0.8	-0.6	-1.0	1.3	0.8	-0.3
Myopia	0.2	0.3	1.2	0.2	-0.2	0.7	-0.3	-0.0	1.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.8	-0.3	-0.4	0.1	-0.0	0.6	0.9
Cholesterol lowering medication	0.3	0.4	0.8	0.9	0.6	0.4	-0.5	-0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.9	3.5	6.0	2.2	1.8	2.4	-2.2	-1.3	0.3
Pain experienced in last month	4.4	7.4	11.5	-3.4	-2.8	-2.0	2.4	2.6	2.9
Supplements: Calcium	0.4	0.5	0.7	0.8	0.8	0.2	-0.6	-0.8	-0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.5	0.6	0.5	-1.1	-0.7	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.6	-0.2	-0.8	0.7	0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	4.5	-1.3	-1.4	-2.1	2.1	1.4	-2.1
Heart disease (siblings)	0.1	0.1	0.2	0.4	0.1	0.4	-0.4	-0.3	0.1
Alcohol drinker status: Previous	0.7	0.7	4.0	0.5	0.1	-0.3	0.3	-0.1	-2.0
Pack years of smoking	4.4	6.5	9.5	-2.7	-2.9	-2.7	2.6	3.1	-0.2
Impedance of whole body	0.7	3.5	5.3	-1.9	-2.0	-2.2	1.3	2.3	1.3
Leg fat mass (left)	2.2	8.4	13.1	3.5	3.1	2.4	-2.6	-3.6	-1.7
Arm predicted mass (left)	2.1	10.7	15.0	3.8	3.6	3.3	-3.3	-3.9	0.3