Hub : Genes

FBXO34

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0490 0.0160 1.2e-08 0.104 0.080 0.089 0.083 0.092 1.3e-12 5.1e-10 5.4e-11 2.6e-10 2.5e-11
2 GTEx Skin Sun Exposed Lower leg 0.0530 0.0270 5.6e-03 -0.003 NA -0.003 NA -0.003 6.4e-01 NA 6.3e-01 NA 9.5e-01
3 GTEx Thyroid 0.1160 0.0410 8.8e-07 0.087 NA 0.055 NA 0.100 3.2e-07 NA 4.8e-05 NA 4.3e-08
4 YFS Blood 0.0406 0.0122 5.9e-14 0.046 0.043 0.037 0.044 0.048 7.8e-15 7.9e-14 3.4e-12 3.4e-14 2.2e-15
5 TCGA Brain Lower Grade Glioma 0.0220 0.0130 2.9e-03 0.022 0.019 0.008 NA 0.011 1.4e-03 2.4e-03 3.5e-02 NA 1.7e-02
6 TCGA Prostate Adenocarcinoma 0.1077 0.0378 2.3e-07 0.079 0.074 0.081 NA 0.084 1.1e-08 3.7e-08 7.4e-09 NA 4.4e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.7 1.1 3.2 0.5 0.3 1.1 -1.3 -0.3 1.8
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 -0.0 -0.3 -0.6 0.2 0.5 -0.5
Depressed Affect (Nagel 2018) 0.0 0.1 0.2 -0.1 -0.1 0.2 -0.4 0.4 -0.0
Depression (Nagel 2018) 0.6 0.8 1.7 -0.9 -0.9 -1.3 0.7 1.1 -0.3
Intelligence (Savage-Jansen 2018) 1.8 5.5 8.9 -2.5 -2.5 -3.0 2.5 2.3 0.3
Neuroticism (Nagel 2018) 0.4 1.0 2.0 0.9 1.0 1.4 -1.4 -0.6 0.3
Schizophrenia (2018) 0.8 1.7 4.3 -0.5 -0.6 -1.6 1.3 0.9 -2.1
Schizophrenia vs Biploar Disorder 0.5 0.6 3.4 0.2 -0.1 -0.4 0.2 0.1 -1.8
Worry (Nagel 2018) 2.1 4.4 7.1 2.3 2.0 2.5 -2.7 -1.8 0.8
Alzheimer’s Disease (in mother) 0.4 0.5 1.0 0.6 0.4 0.7 -1.0 -0.6 0.7
Alzheimer’s Disease (in father) 0.5 0.6 2.5 0.1 -0.2 0.5 -0.6 0.4 1.6
Alzheimer’s Disease (including proxy) 1.0 1.4 4.4 0.7 0.1 1.3 -1.3 -0.2 2.1
Crohns Disease (2017) 0.8 1.7 3.0 1.1 1.6 1.3 -1.2 -1.7 -0.6
Irritable Bowel Disease (IBD) 0.8 1.9 3.0 1.1 1.5 1.7 -1.5 -1.7 -0.3
Ulcerative Colitis (UC) 0.4 0.7 1.7 0.5 0.6 1.3 -1.1 -0.7 0.4
Major Depression (MDD) 0.4 0.5 2.2 0.3 0.5 0.3 0.3 -0.1 -1.5
Reaction Time 1.0 2.0 3.6 -1.2 -1.8 -1.3 0.8 1.9 1.2
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.6 -1.3 -1.3 -1.6 1.5 1.1 -0.7
Breast Cancer 0.0 0.1 0.1 -0.4 -0.2 -0.2 0.3 -0.1 -0.3
Ovarian Cancer 0.1 0.1 0.2 0.2 0.4 -0.0 0.1 -0.5 -0.3
Prostate Cancer 1.0 1.4 4.0 1.1 1.0 1.0 -0.5 -0.9 -2.0
Age at First Birth 1.7 2.5 6.6 -1.6 -1.6 -1.0 0.7 1.2 2.6
Bipolar Disorder (2011) 0.3 0.3 0.7 0.0 -0.5 -0.7 0.3 0.8 -0.5
Body Mass Index (BMI) (2010) 0.6 0.9 1.4 1.2 1.0 0.6 -1.0 -1.2 0.2
Coronary Artery Disease (CAD) 0.5 0.6 1.8 -0.4 -0.5 -0.6 0.8 0.4 -1.4
Crohns Disease (2012) 0.1 0.2 0.6 0.0 0.5 0.4 -0.3 -0.8 0.0
Mean Putamen Volume 0.8 0.9 3.6 0.6 0.6 -0.2 0.1 -0.9 -1.9
Fasting Glucose 0.5 0.6 2.3 -0.9 -0.6 -0.1 -0.2 0.1 1.5
HbA1C 0.1 0.1 0.5 -0.2 -0.2 -0.3 0.7 0.3 0.4
HDL Cholesterol 0.3 0.5 1.2 0.5 0.6 0.5 -0.7 -0.6 1.1
LDL Cholesterol 0.1 0.2 0.5 -0.6 -0.6 -0.0 0.3 0.2 0.7
Lupus 1.0 1.5 3.0 -0.9 -0.7 -1.2 1.6 1.0 -1.7
Neuroticism (2016) 1.3 1.8 3.9 1.4 1.0 1.8 -2.0 -0.6 0.8
Primary Biliary Cirrhosis 2.3 3.3 5.3 1.5 1.6 2.0 -2.3 -1.7 1.8
Rheumatoid Arthritis 0.9 1.2 3.9 0.3 0.1 1.2 -1.4 0.1 2.0
Schizophrenia (2014) 0.2 0.4 1.1 -0.0 -0.5 -1.1 0.4 0.6 -0.7
Triglycerides 0.1 0.2 0.5 -0.6 -0.4 -0.4 0.2 0.1 0.7
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.0 0.4 0.2 0.4 -0.6 -0.4 1.0
Ulcerative Colitis 0.5 0.7 1.6 0.7 0.4 1.1 -1.2 -0.5 0.5
Blood Eosinophil Count 9.0 69.0 95.5 -9.8 -9.4 -8.2 8.3 9.4 2.1
Blood Platelet Count 4.5 52.7 68.9 -8.0 -8.3 -6.6 6.0 8.3 6.0
Blood Red Count 1.3 12.8 15.6 -3.9 -4.0 -3.6 3.1 3.5 3.2
Blood White Count 4.0 29.4 43.4 -5.8 -5.0 -5.8 6.6 5.3 -3.6
Heel T-Score 0.2 1.5 2.6 -1.6 -1.5 -0.6 1.3 1.3 0.6
BMI 2.1 11.9 17.2 4.0 3.8 3.4 -3.1 -4.1 -1.7
Height 0.3 5.8 26.9 1.3 0.2 0.7 -2.4 0.1 5.2
Waist Hip Ratio (WHR) 0.3 1.5 8.4 0.7 0.3 -0.2 0.4 0.2 -2.9
Systolic Blood Pressure 0.8 3.8 7.4 -2.7 -2.0 -0.8 1.4 1.6 2.5
Smoking Status 0.5 1.2 3.6 -0.7 -0.8 -0.8 1.2 0.9 -1.9
Allergy or Eczema 0.4 1.0 1.5 -1.1 -1.2 -0.8 0.8 1.1 1.0
Cardiovascular Disease 0.2 0.7 1.3 0.8 0.7 1.1 -0.9 -1.1 0.3
Hypothyroidism (self reported) 3.7 8.6 10.8 -3.2 -3.0 -3.3 3.3 3.1 -1.0
Respiratory disease 0.0 0.1 0.4 0.1 -0.2 -0.2 0.1 0.2 0.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.7 -1.1 -1.3 -0.9 1.1 1.2 -0.0
Lung FEV1/FVC ratio 0.9 4.7 13.1 -2.0 -2.0 -1.7 0.7 1.9 3.6
Lung FVC 0.4 1.9 7.5 -0.6 -0.5 -1.0 1.4 0.4 -2.7
Neuroticism 0.7 1.6 3.1 0.9 0.9 1.4 -1.8 -0.4 1.5
Chronotype (morning person) 1.5 3.5 5.8 -1.8 -1.9 -2.4 2.1 1.8 -0.5
Hair Pigment 0.1 2.3 11.6 0.9 0.6 0.1 0.6 -1.0 -3.4
Tanning 0.4 5.2 9.6 2.0 2.4 2.6 -1.9 -3.1 -1.0
Hand grip strength (left) 0.2 0.5 1.0 -0.7 -0.2 -0.7 1.0 0.5 -0.9
Number of treatments/medications taken 0.8 1.4 2.6 1.6 0.8 1.0 -1.0 -1.0 -1.5
Average weekly spirits intake 2.0 2.5 3.3 1.8 1.6 1.7 -1.4 -1.8 -1.0
Sensitivity / hurt feelings 0.5 0.9 1.5 0.6 1.2 1.1 -1.1 -1.0 -0.5
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.7 -0.2 -0.4 -0.6 0.3 0.6 -1.3
Hearing difficulty/problems: Yes 0.5 0.7 1.2 -0.8 -1.1 -0.9 0.9 0.8 0.5
Relative age of first facial hair 0.7 1.4 2.7 -1.6 -1.0 -0.8 1.0 1.2 1.2
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 5.7 -0.2 -0.5 -0.8 1.1 0.5 -2.4
Ever used hormone-replacement therapy (HRT) 2.8 3.6 5.4 -1.5 -1.5 -2.1 2.0 1.7 -2.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.2 0.0 -0.2 -0.1 -0.3 -0.4
Systolic blood pressure, automated reading 0.3 0.8 3.5 -0.9 -0.0 0.8 -0.4 -0.1 1.9
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.3 1.2 0.9 0.8 -1.0 -0.7 -0.8
Angina 0.2 0.3 0.7 -0.6 -0.3 -0.6 0.9 0.5 -0.1
Medication for hormone replacement therapy 3.3 3.6 10.4 -1.1 -0.9 -2.1 2.0 1.0 -3.2
Vitamin and mineral supplements 11.7 15.8 21.0 -4.6 -4.5 -3.9 4.3 4.5 0.3
Supplements: Zinc 0.0 0.0 0.1 -0.1 -0.3 -0.4 0.0 0.0 -0.1
Medication: Co-codamol 0.9 1.0 2.6 1.4 0.7 0.2 -0.6 -0.9 -1.6
Medication: Metformin 1.3 1.8 2.5 -1.2 -1.5 -1.2 1.6 1.3 -1.2
Diabetes (father) 0.2 0.2 1.1 0.5 0.0 0.1 -0.0 0.1 -1.0
Diabetes (mother) 0.5 0.6 1.1 0.9 0.7 0.6 -0.7 -1.0 -0.7
Severe depression (siblings) 1.8 2.0 3.3 -0.9 -1.2 -1.8 1.4 1.5 -1.5
Pack years adult smoking proportion 5.7 8.7 11.9 -3.1 -3.2 -3.2 3.1 3.5 -0.4
Impedance of leg (right) 0.2 1.1 1.7 -0.8 -1.2 -1.1 0.6 1.3 1.1
Leg fat-free mass (left) 1.0 5.2 7.7 2.7 2.5 2.2 -2.3 -2.8 -0.1
Trunk fat percentage 0.7 2.8 4.4 2.1 1.8 1.1 -1.7 -2.1 -1.0
Hand grip strength (right) 0.1 0.3 0.9 -1.0 -0.4 -0.2 0.5 0.5 0.5
Townsend deprivation index at recruitment 0.5 0.7 1.5 1.0 0.8 0.4 -0.6 -0.6 -1.2
Current tobacco smoking 1.5 2.5 3.4 -1.5 -1.5 -1.7 1.8 1.7 -1.0
Average weekly fortified wine intake 0.3 0.4 1.4 -0.4 -0.5 -0.3 0.2 0.6 1.2
Maternal smoking around birth 1.0 1.5 2.7 -0.9 -1.7 -1.4 1.2 1.3 -0.4
Fed-up feelings 0.9 1.7 3.5 1.7 1.0 1.4 -1.9 -0.9 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 -0.5 -0.8 -0.9 0.7 0.8 -1.2
Relative age voice broke 1.2 1.9 4.2 -1.8 -1.2 -0.4 0.7 1.4 2.0
Taking other prescription medications 0.2 0.3 1.6 0.2 -0.4 -0.2 0.3 0.2 -1.3
Age when periods started (menarche) 0.9 2.1 4.1 -1.7 -1.7 -0.8 0.9 2.0 1.0
Bilateral oophorectomy (both ovaries removed) 2.4 2.7 4.3 -1.6 -1.5 -2.1 2.1 1.6 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 4.2 -2.0 -1.8 -1.6 1.8 1.7 -0.1
Tinnitus: Yes, but not now, but have in the past 3.4 3.6 5.2 -1.6 -2.3 -2.2 2.0 2.3 -0.2
Qualifications: CSEs or equivalent 1.0 1.3 1.7 1.2 1.2 1.2 -0.9 -1.3 -1.1
Serious illness, injury or assault to yourself 1.1 1.3 6.2 0.7 0.7 0.5 -0.1 -0.5 -2.5
High blood pressure 0.1 0.3 0.7 0.4 0.5 0.3 -0.2 -0.8 -0.6
Hayfever, allergic rhinitis or eczema 1.1 2.5 3.5 -1.9 -1.9 -1.5 1.3 1.7 1.0
Multivitamins +/- minerals 6.7 8.6 12.3 3.5 3.0 3.0 -3.3 -3.2 0.6
Stomach or abdominal pain in last month 0.8 1.0 2.8 1.0 1.1 0.3 -0.5 -0.8 -1.7
Supplements: Glucosamine 7.8 10.2 15.7 4.0 3.5 3.3 -3.6 -3.0 -1.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.9 1.4 0.9 0.6 -1.1 -0.9 -0.2
Medication: Atenolol 0.1 0.1 0.1 -0.4 -0.1 -0.3 0.3 -0.3 0.3
Medication: Levothyroxine sodium 2.2 3.8 4.8 -2.1 -2.1 -2.2 2.1 2.1 -0.5
Sitting height 0.4 3.1 4.2 1.9 1.7 1.3 -2.0 -1.8 1.6
Chronic bronchitis/emphysema (father) 2.0 2.3 3.3 1.1 1.6 1.8 -1.6 -1.5 1.4
High blood pressure (mother) 1.7 2.4 4.2 1.6 1.9 1.0 -0.9 -2.1 -1.4
Body mass index (BMI) 1.6 6.7 10.7 2.9 2.8 2.3 -2.1 -3.3 -1.9
Impedance of leg (left) 0.2 0.9 1.4 -0.8 -1.0 -1.2 0.5 1.1 0.8
Leg predicted mass (left) 1.0 5.1 7.5 2.7 2.5 2.1 -2.3 -2.7 -0.1
Trunk fat mass 1.0 4.4 6.8 2.6 2.3 1.6 -2.2 -2.6 -0.7
Waist circumference 0.8 2.8 4.1 2.0 1.8 1.4 -1.4 -2.0 -1.3
Number of incorrect matches in round 3.1 5.1 6.4 2.2 2.5 2.5 -2.4 -2.1 1.7
Past tobacco smoking 0.4 0.7 3.6 -0.1 0.2 0.4 -0.4 -0.2 1.9
Alcohol usually taken with meals 0.1 0.2 0.4 -0.3 -0.1 -0.6 0.7 0.6 -0.0
Nervous feelings 1.6 3.0 6.2 1.5 1.5 2.1 -2.5 -1.3 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.7 0.4 0.5 0.4 -0.3 -0.4 -1.6
Hearing difficulty/problems with background noise 0.1 0.2 0.5 0.2 -0.7 -0.4 -0.0 0.6 0.1
Hair/balding pattern: Pattern 2 2.9 3.7 5.4 1.9 2.3 2.1 -1.9 -2.2 -0.4
Had menopause 0.3 0.4 0.9 -0.6 -0.6 -0.9 0.3 0.8 -0.2
Had other major operations 0.6 0.8 1.9 -0.6 -0.5 -0.7 1.0 0.7 -1.4
Forced vital capacity (FVC) 0.4 1.7 2.4 1.4 1.4 1.2 -1.4 -1.6 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.0 -1.4 -1.2 -1.2 1.3 0.9 -0.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 4.6 -0.1 -0.5 -0.6 0.8 0.6 -2.1
Qualifications: None of the above 0.6 1.4 2.7 1.5 0.9 1.0 -1.6 -0.8 0.7
Financial difficulties in last 2 years 0.1 0.1 0.2 0.4 0.3 0.1 -0.2 -0.3 -0.3
Mouth/teeth dental problems 0.4 0.7 1.6 0.8 0.6 0.7 -0.8 -0.6 1.3
Heart attack 0.2 0.2 0.5 -0.5 -0.2 -0.7 0.6 0.5 -0.3
Allergy 1.3 2.9 4.2 1.8 2.1 1.7 -1.4 -1.9 -1.2
Pain all over the body in last month 4.2 4.5 5.9 2.4 2.4 2.1 -2.0 -2.4 -1.1
Diabetes (self-reported) 1.6 2.5 3.8 -1.7 -1.9 -1.5 1.6 1.8 -0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 2.2 -0.3 0.0 1.0 -0.6 -0.1 1.5
Medication: Ramipril 2.5 3.2 4.6 -2.0 -1.8 -1.5 2.1 1.9 -1.4
Medication: Simvastatin 0.1 0.2 0.4 0.6 0.2 -0.0 -0.2 -0.5 -0.6
Fluid intelligence score 0.6 1.3 1.7 -1.3 -1.3 -1.2 1.3 1.1 -0.0
Illnesses of siblings 0.2 0.3 1.0 0.6 0.5 0.3 -0.2 -0.5 -1.0
Neuroticism score 0.7 1.5 3.0 1.1 1.3 1.5 -1.7 -0.8 0.1
Weight 2.0 9.6 14.1 3.7 3.4 2.9 -3.1 -3.8 -0.5
Impedance of arm (right) 1.5 7.1 11.1 -2.8 -3.0 -2.9 2.1 3.3 1.4
Arm fat percentage (right) 0.8 3.0 4.5 2.1 1.8 1.3 -1.5 -2.1 -1.3
Trunk fat-free mass 1.3 7.6 9.5 3.1 2.8 3.0 -2.9 -3.1 1.1
Hip circumference 0.8 3.4 5.5 2.0 1.9 1.8 -1.9 -2.3 0.4
Time employed in main current job 3.7 4.3 6.4 1.9 2.0 2.5 -2.5 -2.0 1.2
Alcohol intake versus 10 years previously 0.1 0.2 0.5 0.1 0.3 -0.6 0.3 -0.7 -0.6
Father’s age at death 1.1 1.5 6.0 -0.1 0.4 1.3 -1.1 -0.4 2.4
Worrier / anxious feelings 1.1 2.0 3.2 1.2 1.4 1.7 -1.8 -1.4 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.3 -0.6 -1.1 -0.9 0.5 0.9 -0.5
Falls in the last year 1.1 1.5 6.6 0.9 1.0 -0.2 0.0 -0.9 -2.6
Hair/balding pattern: Pattern 3 0.0 0.1 0.3 0.0 -0.2 -0.1 0.0 0.6 -0.2
Number of live births 2.0 2.9 4.1 -1.2 -1.6 -1.8 2.0 1.8 -1.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.1 0.6 0.8 0.4 -0.8 -1.0 1.0
Pulse rate 2.4 4.1 6.8 1.8 2.6 1.4 -1.2 -2.4 -2.2
Happiness 0.1 0.1 0.2 0.5 0.3 0.2 -0.4 -0.1 -0.4
Noisy workplace 1.2 1.4 7.3 0.3 -0.1 -0.6 0.8 0.1 -2.7
Qualifications: A levels/AS levels or equivalent 0.6 1.3 1.8 -1.3 -1.3 -0.8 1.3 1.3 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.6 0.9 0.6 -0.1 -0.0 -0.8 -1.9
Mouth/teeth dental problems: Dentures 1.3 2.1 8.9 -0.4 -0.6 -1.0 1.3 0.8 -3.0
Asthma 0.7 1.4 1.9 -1.3 -1.2 -1.3 1.4 1.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 2.9 3.7 5.4 2.3 1.6 2.1 -2.3 -1.9 1.1
Medication: Cholesterol lowering 0.9 1.3 5.2 -0.3 -0.4 -1.0 1.2 0.3 -2.3
Depression (self-reported) 0.5 0.6 1.6 1.2 0.6 0.4 -0.9 -0.7 0.1
Medication: Lansoprazole 0.6 0.6 0.9 0.9 0.8 0.6 -0.9 -1.0 -0.4
Prospective memory result 0.8 1.0 2.6 0.1 0.5 1.6 -1.0 -0.3 1.5
Lung cancer (father) 1.3 1.5 2.7 -1.2 -1.4 -1.6 1.3 1.2 0.1
Illnesses of mother 1.6 2.0 3.0 -1.4 -1.5 -1.5 1.4 1.7 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 3.0 1.3 1.5 1.3 -1.7 -1.6 1.4
Pulse wave Arterial Stiffness index 2.0 2.3 4.2 1.6 1.5 2.0 -1.6 -1.5 -0.5
Impedance of arm (left) 1.4 6.6 10.0 -2.7 -2.9 -2.9 1.9 3.2 1.5
Arm fat mass (right) 1.5 6.2 9.7 3.0 2.7 2.0 -2.3 -3.1 -1.2
Trunk predicted mass 1.3 7.7 9.6 3.1 2.9 3.0 -2.9 -3.1 1.2
Standing height 0.5 4.6 11.1 2.0 1.5 1.5 -2.6 -1.3 3.3
Length of working week for main job 0.6 0.6 2.4 0.6 0.4 -0.4 0.3 -0.8 -1.6
Exposure to tobacco smoke at home 1.0 1.2 3.7 0.0 -1.0 -0.8 0.9 0.9 -1.9
Breastfed as a baby 1.8 2.3 3.8 1.5 0.8 1.5 -1.9 -1.0 2.0
Tense / ‘highly strung’ 4.1 6.7 10.1 2.4 2.7 2.9 -3.2 -2.7 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 4.1 1.2 1.1 0.5 -0.6 -0.6 -2.0
Hair/balding pattern: Pattern 4 2.1 5.2 7.4 -2.5 -2.4 -2.7 2.2 2.4 0.6
Birth weight of first child 1.7 3.0 4.6 1.6 1.8 1.8 -2.0 -2.1 0.9
Peak expiratory flow (PEF) 0.3 0.7 4.0 0.0 0.4 0.1 -0.3 -0.4 2.0
Pulse wave reflection index 0.4 0.5 1.3 0.3 0.1 1.1 -0.8 -0.2 1.0
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.0 1.4 0.6 0.3 -0.7 -0.9 -1.4
Loud music exposure frequency 0.7 0.7 1.4 -0.5 -1.0 -1.2 0.9 0.7 -0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.1 -1.3 -1.4 -1.0 1.4 1.2 0.5
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 0.1 0.1 -0.0 -0.4 0.0 0.6
Blood clot in the leg (DVT) 1.9 2.4 4.1 -1.1 -1.2 -2.0 1.8 1.3 -1.6
Medication: Paracetamol 0.3 0.5 1.1 1.1 0.4 0.7 -0.7 -0.6 -0.7
Headache pain in last month 1.1 1.8 2.6 1.4 1.6 1.0 -1.1 -1.4 -1.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.6 -0.5 -0.2 0.1 -0.1 0.5 1.6
Glaucoma (self-reported) 0.4 0.5 2.0 -0.0 0.1 0.8 -0.5 0.2 1.4
Gout (self-reported) 1.5 2.1 3.6 -1.5 -1.4 -1.9 1.7 1.0 -0.9
Hypothyroidism/myxoedema (self-reported) 4.7 9.2 11.9 -3.3 -3.1 -3.5 3.4 3.3 -1.1
Medication: Amlodipine 0.4 0.5 0.7 0.8 0.7 0.8 -0.8 -0.8 0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.4 0.4 0.5 -0.3 -0.4 -0.4
Birth weight 0.1 0.3 0.9 -1.0 -0.2 -0.1 0.5 0.5 0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.2 0.5 0.5 0.0 -0.6 -0.6
High blood pressure (siblings) 0.2 0.2 0.8 -0.7 -0.2 0.1 0.1 0.1 0.9
Forced vital capacity (FVC), Best measure 0.8 2.8 3.6 1.9 1.8 1.7 -1.9 -1.9 0.6
Body fat percentage 1.1 4.2 6.4 2.5 2.2 1.4 -1.9 -2.5 -1.4
Leg fat percentage (right) 1.6 5.9 9.0 3.0 2.5 1.9 -2.0 -2.9 -1.9
Arm fat-free mass (right) 1.8 9.3 12.9 3.6 3.2 3.1 -3.1 -3.6 0.2
Exposure to tobacco smoke outside home 0.0 0.1 0.2 0.2 -0.1 -0.3 -0.4 0.2 0.2
Comparative body size at age 10 0.3 0.7 1.3 1.1 0.9 0.5 -0.8 -1.2 -0.2
Number of full brothers 0.1 0.1 0.3 0.2 -0.5 -0.1 0.0 0.5 0.3
Worry too long after embarrassment 0.4 0.7 1.5 0.7 1.2 0.8 -0.9 -0.8 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.7 0.2 -0.0 -0.2 0.3 0.5 -1.6
Wheeze or whistling in the chest in last year 1.2 2.1 3.4 -1.2 -1.1 -1.8 1.9 1.2 -1.3
Number of children fathered 2.3 2.5 10.0 -0.1 -0.3 -1.6 1.6 0.4 -3.2
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 1.8 1.3 1.2 1.1 -1.3 -1.2 0.8
Age at first live birth 0.8 1.4 2.2 -1.2 -1.5 -1.2 0.8 1.2 1.2
Pulse wave peak to peak time 1.7 2.0 3.5 -1.4 -1.4 -1.9 1.4 1.4 0.8
Health satisfaction 2.4 3.2 9.9 2.0 1.4 0.9 -0.7 -1.3 -3.1
Shortness of breath walking on level ground 0.2 0.3 0.8 -0.0 -0.4 -0.4 0.5 0.4 -0.9
Qualifications: College or University degree 1.2 3.9 5.7 -2.1 -2.0 -2.0 2.4 2.3 -0.1
Eye problems/disorders: None of the above 0.4 0.4 0.7 -0.9 -0.5 -0.7 0.8 0.7 -0.1
Mouth/teeth dental problems: Loose teeth 2.7 3.3 6.4 -1.3 -1.6 -1.6 1.8 1.7 -2.5
Emphysema/chronic bronchitis 1.8 2.0 3.3 -1.4 -1.7 -1.4 1.3 1.8 0.4
Medication for pain relief, constipation, heartburn 1.1 1.9 3.5 -1.9 -1.2 -1.5 1.4 1.4 0.4
Neck or shoulder pain in last month 0.5 0.7 2.2 0.6 0.8 0.5 -0.4 -0.7 -1.5
Medication: Blood pressure 0.3 0.5 2.4 0.2 0.3 0.3 0.1 -0.5 -1.6
Angina (self-reported) 0.3 0.4 0.9 -0.7 -0.3 -0.6 0.9 0.4 -0.4
Migraine (self-reported) 1.0 1.2 6.4 0.5 0.2 -0.7 0.3 -0.3 -2.5
Medication: Ibuprofen 2.4 2.8 5.6 2.4 1.5 1.6 -1.9 -1.6 0.4
Medication: Allopurinol 0.4 0.6 1.0 -0.8 -0.9 -0.8 1.0 0.6 -0.2
Medication: Omeprazole 1.8 2.1 3.5 1.7 1.2 1.8 -1.9 -0.8 0.9
Medication: Seretide 50 evohaler 2.0 2.3 3.3 -1.2 -1.8 -1.8 1.7 1.5 -0.6
Mean time to correctly identify matches 1.5 2.8 5.1 -1.6 -2.1 -1.6 1.1 2.3 0.7
Heart disease (mother) 0.6 0.7 1.1 0.9 1.0 0.9 -0.8 -1.0 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.2 -0.7 0.1 -0.4 0.6 -0.1 -1.1
Whole body fat mass 1.4 5.6 9.0 2.9 2.6 1.9 -2.3 -3.0 -1.0
Leg fat mass (right) 2.0 7.7 11.8 3.4 3.0 2.4 -2.6 -3.4 -1.4
Arm predicted mass (right) 1.7 8.5 11.9 3.4 3.1 3.0 -3.0 -3.4 0.4
Pulse rate, automated reading 4.1 13.3 19.8 3.7 4.4 3.8 -3.1 -4.5 -1.7
Alcohol intake frequency. 0.4 1.0 4.7 0.1 -0.0 -0.9 0.7 0.1 -2.2
Comparative height size at age 10 0.5 2.9 4.7 2.2 1.7 1.2 -2.2 -1.5 1.1
Number of full sisters 2.2 2.7 4.1 -1.6 -1.8 -1.8 1.7 2.0 -0.8
Suffer from ‘nerves’ 1.9 3.0 5.2 1.7 1.7 2.1 -2.3 -1.4 0.8
Overall health rating 1.7 3.7 5.2 2.1 2.1 1.2 -1.4 -2.2 -2.3
Chest pain or discomfort 1.9 2.8 5.3 -1.1 -1.6 -2.3 1.7 1.8 -1.2
Had major operations 0.5 0.6 1.1 1.0 0.6 0.1 -0.4 -1.0 -0.9
Age at last live birth 0.3 0.5 1.0 -0.4 -0.8 -0.8 0.3 1.0 0.6
Family relationship satisfaction 0.6 0.7 2.8 -0.2 -0.6 -0.5 0.5 0.9 -1.7
Leg pain on walking 3.2 4.0 5.7 2.4 2.1 1.8 -1.5 -1.6 -2.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.5 -0.4 -0.3 -0.7 0.6 0.3 -0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.0 0.1 0.1 0.7 -0.9 -0.2 1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.9 -0.8 -0.4 -0.2 0.5 0.4 1.4
Medication: Aspirin 0.2 0.3 0.9 0.6 0.3 0.1 -0.2 -0.4 -0.9
Supplements: Vitamin C 2.7 3.2 4.9 1.7 2.0 1.9 -1.9 -2.2 0.1
Knee pain experienced in last month 8.3 12.9 15.7 4.0 4.0 3.9 -3.7 -3.8 -1.6
Hypertension (Self-reported) 0.0 0.1 0.3 -0.1 0.2 -0.0 0.1 -0.5 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 0.3 0.1 0.7 -0.4 -0.2 0.6
Illnesses of father: Heart disease 0.7 1.0 2.1 -1.0 -0.8 -1.5 1.0 0.8 0.4
Illnesses of siblings: Diabetes 0.3 0.4 0.7 -0.4 -0.7 -0.3 0.5 0.8 0.8
Smoking status: Previous 0.3 0.4 2.3 0.5 0.1 -0.1 0.1 -0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.2 0.7 0.9 0.8 -1.1 -0.7 1.5
Whole body fat-free mass 1.3 7.5 10.2 3.2 2.9 2.8 -2.8 -3.2 0.4
Leg fat-free mass (right) 1.0 5.2 7.8 2.7 2.5 2.1 -2.3 -2.8 -0.1
Arm fat percentage (left) 0.7 2.8 4.2 2.0 1.7 1.2 -1.5 -2.0 -1.4
Average weekly red wine intake 0.0 0.0 0.1 -0.0 0.3 0.1 0.1 -0.3 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.6 0.2 0.3 -0.5 -0.2 0.8
Mood swings 1.0 1.8 2.7 1.2 1.6 1.6 -1.7 -1.2 -0.3
Loneliness, isolation 0.7 0.9 2.4 0.6 0.9 1.6 -1.2 -0.7 -0.1
Long-standing illness, disability or infirmity 0.9 1.3 1.8 -1.3 -1.2 -1.1 1.3 1.2 -0.6
Ever had bowel cancer screening 0.8 1.0 1.7 -0.9 -1.2 -0.9 0.8 1.3 -0.7
Diabetes diagnosed by doctor 2.3 3.7 5.8 -1.9 -2.4 -2.0 1.9 2.3 0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 3.2 -0.9 -1.3 -1.8 1.6 1.3 -1.3
Friendships satisfaction 0.2 0.3 1.2 0.5 0.0 0.3 -0.2 -0.0 -1.1
Qualifications: nursing, teaching 3.0 4.6 6.9 -2.2 -2.1 -2.3 2.6 2.0 -1.5
Commuting to job workplace: Walk 1.0 1.1 5.0 -1.1 -0.4 -0.1 0.1 0.4 2.2
Eye problems/disorders: Cataract 0.6 0.7 1.2 -0.8 -1.1 -1.0 0.8 0.8 0.1
Mouth/teeth dental problems: Mouth ulcers 1.5 2.5 3.1 1.6 1.8 1.7 -1.8 -1.8 -0.1
Medication for cholesterol 0.3 0.4 0.9 0.3 0.5 0.9 -0.7 -0.3 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 3.1 -0.2 0.0 0.4 -0.6 -0.4 1.8
Back pain experienced in last month 1.0 1.5 3.5 1.9 1.0 1.0 -1.3 -1.2 -0.6
Mineral and other dietary supplements 6.5 8.8 13.4 -3.7 -2.7 -3.0 3.6 2.9 -1.3
Breast cancer (self-reported) 0.4 0.5 1.5 -0.5 -0.0 -0.7 0.9 0.2 -1.2
Asthma (self-reported) 0.9 1.8 2.4 -1.6 -1.5 -1.4 1.6 1.4 -0.0
Osteoporosis (self-reported) 0.6 0.7 1.3 -0.7 -0.9 -1.1 0.8 0.9 0.4
Osteoarthritis (self-reported) 0.7 0.9 1.8 1.3 0.9 0.8 -0.9 -1.0 -0.7
Medication: Aspirin 0.3 0.4 2.1 0.5 0.3 -0.2 0.1 -0.3 -1.5
Medication: Gliclazide 0.4 0.4 0.9 0.5 0.3 0.8 -0.7 -0.4 1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.2 -0.3 -0.5 -0.3 0.5 0.5 -0.3
Smoking status: Current 1.1 1.7 2.2 -1.3 -1.3 -1.4 1.5 1.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.2 -0.1 -0.4 -0.3 -0.1 0.3 1.5
Whole body water mass 1.3 7.4 10.1 3.2 2.9 2.8 -2.8 -3.1 0.4
Leg predicted mass (right) 0.9 4.7 7.2 2.5 2.4 2.0 -2.2 -2.7 0.0
Arm fat mass (left) 1.5 6.2 9.7 3.0 2.7 2.1 -2.4 -3.1 -1.0
Number of self-reported non-cancer illnesses 0.1 0.1 0.6 0.1 -0.3 -0.2 0.2 0.0 -0.8
Average weekly champagne plus white wine intake 0.4 0.5 1.3 -0.4 -0.7 -1.1 0.9 0.6 0.1
Miserableness 0.9 1.6 2.7 -1.0 -1.2 -1.3 1.0 1.6 -1.3
Guilty feelings 1.3 2.0 3.5 1.5 1.3 1.7 -1.9 -0.8 1.0
Wears glasses or contact lenses 1.6 1.8 3.2 -1.5 -1.8 -0.8 0.9 1.6 1.1
Ever taken oral contraceptive pill 2.2 2.5 3.8 -1.2 -1.2 -1.7 1.9 1.4 -1.9
Hearing aid user 1.0 1.2 2.6 -0.3 -0.6 -1.6 1.3 0.6 -1.4
Mother’s age at death 0.2 0.2 0.4 0.5 0.5 0.6 -0.5 -0.1 0.6
Financial situation satisfaction 0.4 0.4 1.5 0.7 0.5 0.5 -0.4 0.0 -1.2
Tinnitus: Yes, now most or all of the time 2.9 3.4 5.4 -1.9 -1.8 -2.1 2.3 1.8 -0.7
Commuting to job workplace: Public transport 0.8 1.0 1.5 -1.1 -1.0 -0.6 1.2 1.1 0.5
Eye problems/disorders: Glaucoma 0.4 0.4 2.0 -0.3 -0.1 0.7 -0.2 0.2 1.4
Medication: Blood pressure 0.2 0.3 0.5 -0.5 -0.7 -0.5 0.3 0.6 0.6
Pain type(s) experienced in last month: Hip pain 1.4 1.7 3.1 1.8 1.0 1.5 -1.2 -0.7 -1.5
Supplements: Fish oil (including cod liver oil) 8.0 10.5 15.0 3.5 2.8 3.5 -3.9 -3.2 2.3
High cholesterol (Self-reported) 0.7 1.3 2.5 1.4 1.0 0.8 -0.8 -1.1 -1.6
Medication: Bendroflumethiazide 0.8 1.2 1.6 1.1 0.7 1.1 -1.3 -1.2 1.1
Medication: Paracetamol 1.7 2.6 4.8 2.2 1.4 1.3 -1.4 -1.4 -1.8
Medication: Lisinopril 0.7 0.9 2.2 -0.4 -0.7 -1.0 1.0 0.8 -1.5
Medication: Atorvastatin 0.5 0.6 2.3 -0.1 -0.2 -0.7 0.8 0.2 -1.5
Illnesses of father: High blood pressure 0.5 0.6 1.1 0.5 1.0 0.7 -0.6 -1.1 -0.5
Alcohol drinker status: Never 2.0 2.4 3.8 -1.7 -1.3 -1.6 1.9 1.7 -0.8
Ever smoked 0.8 1.3 2.9 1.1 1.2 1.0 -0.7 -1.0 -1.7
Basal metabolic rate 1.5 8.3 11.7 3.4 3.1 2.8 -3.0 -3.4 0.2
Leg fat percentage (left) 1.8 6.6 10.0 3.0 2.7 1.9 -2.0 -3.2 -2.3
Arm fat-free mass (left) 1.9 9.8 14.1 3.7 3.4 3.1 -3.2 -3.8 0.1
Number of operations (self-reported) 1.1 1.6 7.8 -0.0 -0.3 -0.8 1.1 0.2 -2.8
Average weekly beer plus cider intake 0.8 1.2 1.9 1.1 1.2 1.4 -1.2 -1.1 0.4
Irritability 0.0 0.1 0.1 0.1 -0.1 0.3 -0.3 0.2 -0.3
Risk taking 0.8 1.2 3.4 1.3 0.9 0.6 -0.6 -0.8 -1.8
Ever had prostate specific antigen (PSA) test 9.1 10.5 13.9 3.7 3.1 3.5 -3.7 -3.4 1.3
Fractured/broken bones in last 5 years 1.8 2.3 3.2 1.5 1.7 1.4 -1.2 -1.8 -1.5
Age started oral contraceptive pill 0.2 0.2 0.4 0.4 0.2 0.6 -0.5 0.1 0.5
Diastolic blood pressure, automated reading 2.1 6.6 11.1 2.0 2.7 2.9 -2.7 -3.3 1.3
Ever depressed for a whole week 0.4 0.5 1.7 -0.1 -0.6 -0.6 0.8 0.5 -1.3
Unable to work because of sickness or disability 0.7 0.9 2.5 -0.7 -0.8 -0.6 0.8 0.7 -1.6
Commuting to job workplace: Cycle 0.6 0.8 1.7 -0.8 -0.6 -1.0 1.3 0.8 -0.3
Myopia 0.2 0.3 1.2 0.2 -0.2 0.7 -0.3 -0.0 1.1
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.8 -0.3 -0.4 0.1 -0.0 0.6 0.9
Cholesterol lowering medication 0.3 0.4 0.8 0.9 0.6 0.4 -0.5 -0.8 -0.1
Medication: Omeprazole (e.g. Zanprol) 2.9 3.5 6.0 2.2 1.8 2.4 -2.2 -1.3 0.3
Pain experienced in last month 4.4 7.4 11.5 -3.4 -2.8 -2.0 2.4 2.6 2.9
Supplements: Calcium 0.4 0.5 0.7 0.8 0.8 0.2 -0.6 -0.8 -0.7
Basal cell carcinoma (self-reported) 0.4 0.5 1.2 0.5 0.6 0.5 -1.1 -0.7 0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.6 -0.6 -0.2 -0.8 0.7 0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 4.5 -1.3 -1.4 -2.1 2.1 1.4 -2.1
Heart disease (siblings) 0.1 0.1 0.2 0.4 0.1 0.4 -0.4 -0.3 0.1
Alcohol drinker status: Previous 0.7 0.7 4.0 0.5 0.1 -0.3 0.3 -0.1 -2.0
Pack years of smoking 4.4 6.5 9.5 -2.7 -2.9 -2.7 2.6 3.1 -0.2
Impedance of whole body 0.7 3.5 5.3 -1.9 -2.0 -2.2 1.3 2.3 1.3
Leg fat mass (left) 2.2 8.4 13.1 3.5 3.1 2.4 -2.6 -3.6 -1.7
Arm predicted mass (left) 2.1 10.7 15.0 3.8 3.6 3.3 -3.3 -3.9 0.3