Hub : Genes

WDHD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.0190	1.6e-07	0.086	0.066	0.089	0.086	0.089	1.3e-10	1.7e-08	5.7e-11	1.3e-10	6.3e-11
2	GTEx	Adrenal Gland	0.175	0.0812	7.7e-03	0.125	NA	0.060	NA	0.090	3.2e-05	NA	3.3e-03	NA	3.9e-04
3	GTEx	Esophagus Mucosa	0.103	0.0420	1.1e-03	0.012	NA	0.031	NA	0.009	5.1e-02	NA	3.4e-03	NA	7.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.5	1.2	0.8	0.1
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-0.0	-1.1	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	1.2	0.4	1.1	-0.8
Depression (Nagel 2018)	0.4	0.5	0.8	-0.9	-0.9	-0.3
Intelligence (Savage-Jansen 2018)	2.8	8.7	13.8	-2.6	-2.4	3.7
Neuroticism (Nagel 2018)	0.2	0.5	0.7	0.1	0.8	-0.8
Schizophrenia (2018)	0.9	1.9	4.1	-0.9	-2.0	0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.3	-1.0	-1.1	-0.4
Worry (Nagel 2018)	0.5	1.1	1.8	0.5	1.1	-1.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	-0.1	0.3	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.4	0.6	0.3
Alzheimer’s Disease (including proxy)	0.5	0.8	1.2	0.8	1.1	-0.8
Crohns Disease (2017)	0.5	1.2	1.5	1.2	1.2	-0.7
Irritable Bowel Disease (IBD)	1.0	2.4	2.8	1.6	1.7	-1.3
Ulcerative Colitis (UC)	1.1	2.0	2.5	1.5	1.6	-1.1
Major Depression (MDD)	0.0	0.0	0.1	-0.2	-0.1	0.3
Reaction Time	0.1	0.2	0.6	-0.3	-0.7	0.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.6	-1.1	-1.4	2.4
Breast Cancer	0.0	0.1	0.3	0.1	-0.0	-0.5
Ovarian Cancer	0.2	0.3	0.5	0.5	0.7	-0.4
Prostate Cancer	0.2	0.3	1.0	0.2	-0.0	-1.0
Age at First Birth	0.7	1.1	1.5	-1.2	-0.9	1.0
Bipolar Disorder (2011)	0.4	0.4	0.8	0.5	0.0	0.9
Body Mass Index (BMI) (2010)	1.0	1.3	2.1	1.1	0.8	-1.5
Coronary Artery Disease (CAD)	0.3	0.4	0.6	-0.7	0.2	-0.8
Crohns Disease (2012)	0.1	0.2	0.4	0.6	0.3	0.3
Mean Putamen Volume	0.5	0.6	1.6	-0.5	-1.3	0.0
Fasting Glucose	0.3	0.3	0.4	-0.6	-0.5	0.6
HbA1C	1.2	1.3	1.8	1.1	1.3	1.0
HDL Cholesterol	0.7	1.2	2.4	1.0	1.5	-0.6
LDL Cholesterol	0.4	0.6	0.7	-0.8	-0.7	0.7
Lupus	0.3	0.5	0.7	-0.8	-0.8	-0.1
Neuroticism (2016)	2.3	3.3	6.6	1.4	2.6	-1.1
Primary Biliary Cirrhosis	1.1	1.6	2.5	1.6	1.3	-0.8
Rheumatoid Arthritis	1.5	2.1	2.2	1.4	1.5	-1.4
Schizophrenia (2014)	0.5	1.2	2.7	-0.7	-1.7	0.7
Triglycerides	0.1	0.2	0.4	-0.4	-0.7	-0.3
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.5	1.6	1.2	-0.3
Ulcerative Colitis	1.1	1.6	2.1	1.3	0.9	-1.4
Blood Eosinophil Count	7.6	58.5	68.0	-8.1	-6.4	8.2
Blood Platelet Count	2.6	30.6	47.3	-5.2	-4.1	6.9
Blood Red Count	1.4	13.9	17.3	-4.2	-3.9	3.0
Blood White Count	3.9	28.7	33.6	-5.7	-4.4	5.8
Heel T-Score	0.2	1.4	1.8	-1.3	-1.1	1.0
BMI	1.4	8.0	11.8	2.7	2.2	-3.4
Height	0.2	4.1	9.5	0.9	3.1	-1.4
Waist Hip Ratio (WHR)	0.1	0.6	1.1	-0.4	1.1	-0.7
Systolic Blood Pressure	0.7	3.7	4.2	-1.8	-2.0	2.0
Smoking Status	0.2	0.5	1.4	-0.3	-0.3	1.2
Allergy or Eczema	0.3	0.7	1.9	0.2	-0.5	1.4
Cardiovascular Disease	0.2	0.8	2.1	-0.3	0.5	-1.4
Hypothyroidism (self reported)	2.6	6.0	6.5	-2.5	-2.4	2.4
Respiratory disease	0.1	0.3	0.5	-0.5	-0.4	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.5	0.1	1.0
Lung FEV1/FVC ratio	0.6	2.9	3.7	-1.9	-1.9	1.2
Lung FVC	0.1	0.7	1.8	1.3	0.2	0.6
Neuroticism	0.2	0.6	1.5	0.2	1.2	-0.5
Chronotype (morning person)	1.8	4.2	4.6	-1.9	-2.1	2.2
Hair Pigment	0.0	0.5	1.1	-0.1	-1.1	-0.5
Tanning	0.2	1.8	3.0	1.1	1.7	-1.1
Hand grip strength (left)	1.2	3.0	5.0	-1.6	-1.3	2.2
Number of treatments/medications taken	0.5	1.0	2.5	0.4	0.4	-1.6
Average weekly spirits intake	1.1	1.4	2.3	1.5	0.9	-1.1
Sensitivity / hurt feelings	0.5	0.8	1.5	0.9	1.2	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-0.5	-0.9	-0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.3	0.4	1.1
Relative age of first facial hair	0.2	0.5	0.6	-0.7	-0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.7	-0.8	0.4
Ever used hormone-replacement therapy (HRT)	2.2	2.8	4.9	-2.2	-1.9	0.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.8	0.6	-0.4
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.3	0.2	0.6
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.0	1.3	1.0	-1.7
Angina	0.1	0.1	0.2	-0.4	-0.2	0.5
Medication for hormone replacement therapy	3.4	3.8	5.3	-1.9	-2.3	1.6
Vitamin and mineral supplements	6.8	9.3	9.8	-3.1	-2.9	3.1
Supplements: Zinc	0.3	0.3	0.7	0.5	0.1	-0.9
Medication: Co-codamol	0.0	0.0	0.1	0.0	0.1	-0.3
Medication: Metformin	0.7	1.0	1.8	-1.0	-0.2	1.4
Diabetes (father)	0.7	0.8	1.6	-0.5	0.7	-1.3
Diabetes (mother)	0.3	0.3	0.4	0.5	0.6	-0.6
Severe depression (siblings)	2.3	2.5	4.8	-1.5	-2.2	0.8
Pack years adult smoking proportion	3.7	5.7	6.6	-2.6	-2.3	2.3
Impedance of leg (right)	0.2	1.2	2.4	-1.6	-1.0	-0.1
Leg fat-free mass (left)	1.2	6.3	8.5	2.6	2.9	-1.9
Trunk fat percentage	2.0	7.9	15.7	1.6	2.4	-4.0
Hand grip strength (right)	0.6	1.5	4.4	-0.4	-0.2	2.1
Townsend deprivation index at recruitment	0.8	1.1	1.8	1.0	0.8	-1.3
Current tobacco smoking	2.4	4.0	4.6	-1.7	-2.1	2.2
Average weekly fortified wine intake	1.0	1.1	2.1	-1.5	-1.0	0.5
Maternal smoking around birth	1.0	1.5	1.8	-1.3	-1.2	1.1
Fed-up feelings	2.0	3.6	4.4	2.0	2.1	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.3	-1.0	-1.5	0.0
Relative age voice broke	0.7	1.0	1.9	-1.4	-0.9	0.5
Taking other prescription medications	0.1	0.1	0.2	-0.4	-0.5	-0.1
Age when periods started (menarche)	0.1	0.2	0.7	-0.8	0.1	0.1
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	5.2	-1.7	-2.3	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.3	-1.5	-1.5	-0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.1	-0.2	-1.2	1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.8	0.8	0.3	-1.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.5	-0.2
High blood pressure	0.0	0.0	0.0	0.1	-0.0	0.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	3.6	-1.1	-1.8	1.9
Multivitamins +/- minerals	4.7	6.0	7.1	2.6	2.7	-2.0
Stomach or abdominal pain in last month	0.3	0.3	0.4	0.6	0.4	-0.6
Supplements: Glucosamine	9.5	12.3	16.5	3.0	3.4	-4.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.8	-0.5	0.3	-2.2
Medication: Atenolol	0.1	0.2	0.3	-0.2	-0.5	0.4
Medication: Levothyroxine sodium	1.9	3.3	4.3	-2.0	-2.1	1.2
Sitting height	0.6	4.1	6.3	2.1	2.5	-1.2
Chronic bronchitis/emphysema (father)	0.9	1.0	1.7	1.3	1.2	0.3
High blood pressure (mother)	0.7	1.0	1.7	1.3	1.1	-0.0
Body mass index (BMI)	1.6	6.8	8.4	2.7	2.2	-2.9
Impedance of leg (left)	0.2	0.8	1.7	-1.3	-0.7	-0.2
Leg predicted mass (left)	1.1	6.0	8.0	2.6	2.8	-1.8
Trunk fat mass	2.1	8.9	13.2	2.2	2.9	-3.6
Waist circumference	1.4	5.1	7.0	1.8	2.2	-2.7
Number of incorrect matches in round	2.3	3.8	4.7	1.8	2.2	-1.8
Past tobacco smoking	0.0	0.1	0.2	0.1	-0.4	0.1
Alcohol usually taken with meals	1.9	3.0	4.1	-2.0	-2.0	1.0
Nervous feelings	0.5	0.9	1.9	0.5	0.8	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.5	-0.7	-0.7	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.2	-0.6	-0.3
Hair/balding pattern: Pattern 2	1.7	2.2	3.3	1.1	1.4	-1.8
Had menopause	0.1	0.1	0.3	0.0	-0.2	-0.5
Had other major operations	0.6	0.7	1.4	-0.8	-1.2	0.3
Forced vital capacity (FVC)	1.2	4.5	8.3	2.3	2.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.0	-1.4	-1.1	0.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	-1.3	-1.4	0.3
Qualifications: None of the above	1.1	2.3	3.2	1.1	1.6	-1.8
Financial difficulties in last 2 years	0.2	0.3	0.5	0.5	0.7	0.1
Mouth/teeth dental problems	0.1	0.2	0.3	0.6	0.4	0.4
Heart attack	0.6	0.8	1.2	-1.1	-1.1	0.2
Allergy	1.2	2.8	4.3	1.3	2.1	-1.5
Pain all over the body in last month	4.3	4.6	7.0	1.7	2.0	-2.6
Diabetes (self-reported)	1.3	2.0	2.9	-1.7	-1.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.6	0.8	0.8
Medication: Ramipril	1.8	2.4	2.8	-1.7	-1.2	1.7
Medication: Simvastatin	0.1	0.1	0.3	-0.5	-0.1	-0.3
Fluid intelligence score	1.6	3.4	6.9	-1.3	-1.2	2.6
Illnesses of siblings	0.7	1.0	1.2	1.0	0.8	-1.1
Neuroticism score	0.5	1.0	1.3	0.7	1.2	-1.1
Weight	2.3	11.4	11.8	3.4	3.4	-3.4
Impedance of arm (right)	1.0	4.6	11.0	-3.3	-1.6	-0.4
Arm fat percentage (right)	1.7	6.8	13.7	1.6	2.0	-3.7
Trunk fat-free mass	1.2	6.7	10.4	3.2	3.0	-0.7
Hip circumference	1.1	4.9	6.3	2.2	1.9	-2.5
Time employed in main current job	2.5	2.9	4.2	1.6	2.1	-1.4
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	-0.3	0.7
Father’s age at death	0.6	0.8	1.6	0.8	1.3	-0.1
Worrier / anxious feelings	0.2	0.4	0.5	-0.0	0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	-0.5	-0.6	-0.6
Falls in the last year	0.5	0.7	1.2	0.7	0.6	-1.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.6	0.2	-0.2
Number of live births	1.2	1.7	2.3	-1.5	-1.5	0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.5	1.7	2.1	0.3
Pulse rate	2.6	4.4	5.2	2.2	2.3	-1.7
Happiness	0.1	0.1	0.3	0.1	-0.3	-0.6
Noisy workplace	0.1	0.1	0.3	0.1	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	1.8	3.9	5.6	-1.9	-1.6	2.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	0.7	0.4	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.8	-0.9	-0.4
Asthma	0.7	1.3	1.8	-1.3	-1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	4.3	5.5	8.6	2.6	2.9	-1.0
Medication: Cholesterol lowering	1.0	1.6	3.3	-1.8	-0.9	-0.7
Depression (self-reported)	0.1	0.1	0.4	0.6	-0.1	-0.2
Medication: Lansoprazole	0.3	0.3	0.8	-0.0	0.3	-0.9
Prospective memory result	1.4	1.7	3.5	1.3	1.9	-0.1
Lung cancer (father)	1.6	1.9	2.7	-1.1	-1.3	1.6
Illnesses of mother	1.7	2.1	2.9	-1.2	-1.4	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	7.7	2.6	2.8	-1.1
Pulse wave Arterial Stiffness index	4.5	5.3	6.7	2.6	2.5	-1.7
Impedance of arm (left)	0.9	4.1	9.4	-3.1	-1.6	-0.7
Arm fat mass (right)	2.1	8.8	12.3	2.6	2.8	-3.5
Trunk predicted mass	1.2	6.7	10.5	3.2	3.0	-0.7
Standing height	0.4	4.2	8.9	1.6	3.0	-1.0
Length of working week for main job	0.1	0.1	0.3	0.1	-0.1	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.3	-0.2	0.6
Breastfed as a baby	3.6	4.4	6.8	2.1	2.6	-1.5
Tense / ‘highly strung’	1.3	2.1	2.5	1.5	1.6	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.2	-0.3	-0.6
Hair/balding pattern: Pattern 4	1.9	4.6	5.5	-2.3	-2.2	1.8
Birth weight of first child	3.4	6.2	8.1	2.5	2.9	-2.0
Peak expiratory flow (PEF)	0.8	1.8	2.1	1.2	1.4	1.4
Pulse wave reflection index	0.6	0.7	1.2	1.1	0.7	-0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.1	0.3	0.2	-1.4
Loud music exposure frequency	0.4	0.4	1.0	-1.0	-0.3	0.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	2.9	-1.4	-1.5	1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	0.8	0.8	0.9	-0.9
Blood clot in the leg (DVT)	2.0	2.6	3.0	-1.3	-1.7	1.7
Medication: Paracetamol	0.6	0.9	1.6	0.4	1.3	-1.0
Headache pain in last month	0.9	1.5	2.0	1.2	1.4	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.2	1.0	0.3	1.5
Glaucoma (self-reported)	1.3	1.5	4.0	0.3	0.6	-2.0
Gout (self-reported)	2.5	3.4	4.3	-1.9	-2.1	1.6
Hypothyroidism/myxoedema (self-reported)	3.2	6.3	7.5	-2.7	-2.4	2.4
Medication: Amlodipine	0.8	1.1	2.0	0.7	0.9	-1.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.1	-0.3	0.6
Birth weight	0.2	0.4	0.9	0.4	0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	-0.6	-0.2	-0.6
High blood pressure (siblings)	0.3	0.5	1.2	-0.3	-0.3	1.1
Forced vital capacity (FVC), Best measure	1.8	6.7	9.9	2.9	3.1	-1.4
Body fat percentage	2.2	8.6	16.3	2.0	2.4	-4.0
Leg fat percentage (right)	1.9	7.0	10.8	2.5	2.0	-3.3
Arm fat-free mass (right)	1.6	8.3	12.5	3.5	3.3	-1.3
Exposure to tobacco smoke outside home	0.4	0.5	1.0	1.0	0.7	0.1
Comparative body size at age 10	0.2	0.7	1.1	1.0	-0.1	-1.1
Number of full brothers	0.4	0.5	0.9	-0.1	-0.9	-0.9
Worry too long after embarrassment	0.2	0.4	1.1	0.1	0.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-0.8	-1.0	0.5
Wheeze or whistling in the chest in last year	2.7	4.8	6.3	-2.3	-2.5	1.7
Number of children fathered	0.2	0.2	0.4	0.1	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.2	-0.3	-0.9
Age at first live birth	0.8	1.5	2.4	-1.6	-1.0	1.0
Pulse wave peak to peak time	3.8	4.4	5.8	-2.4	-2.2	1.6
Health satisfaction	2.0	2.5	5.2	1.1	1.1	-2.3
Shortness of breath walking on level ground	0.3	0.3	1.0	0.1	-0.0	-1.0
Qualifications: College or University degree	1.5	4.6	5.2	-2.0	-2.3	2.1
Eye problems/disorders: None of the above	2.2	2.6	3.0	-1.7	-1.4	1.7
Mouth/teeth dental problems: Loose teeth	4.4	5.2	9.4	-3.1	-2.3	1.0
Emphysema/chronic bronchitis	1.3	1.4	1.9	-1.2	-1.0	1.4
Medication for pain relief, constipation, heartburn	1.4	2.5	4.0	-1.0	-1.5	2.0
Neck or shoulder pain in last month	0.9	1.3	1.7	1.2	0.9	-1.3
Medication: Blood pressure	0.4	0.6	1.2	-0.8	-0.0	-1.1
Angina (self-reported)	0.1	0.1	0.2	-0.3	-0.1	0.4
Migraine (self-reported)	0.1	0.1	0.2	0.1	-0.2	-0.4
Medication: Ibuprofen	4.2	5.1	7.3	2.6	2.7	-1.1
Medication: Allopurinol	1.5	2.0	2.8	-1.5	-1.7	1.0
Medication: Omeprazole	1.9	2.3	4.7	0.7	1.3	-2.2
Medication: Seretide 50 evohaler	2.1	2.4	3.3	-1.5	-1.2	1.8
Mean time to correctly identify matches	0.3	0.5	0.9	-0.8	-0.9	0.1
Heart disease (mother)	0.1	0.2	0.2	0.4	0.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	-0.7	-0.7	0.5
Whole body fat mass	2.2	9.3	13.1	2.5	2.9	-3.6
Leg fat mass (right)	2.4	9.4	12.1	2.9	2.8	-3.5
Arm predicted mass (right)	1.3	6.7	10.3	3.2	2.9	-1.2
Pulse rate, automated reading	3.8	12.2	14.4	3.3	3.8	-3.4
Alcohol intake frequency.	0.1	0.2	0.2	0.3	0.4	0.5
Comparative height size at age 10	0.3	1.7	2.9	1.2	1.7	-0.9
Number of full sisters	1.2	1.4	2.8	-0.9	-0.8	1.7
Suffer from ‘nerves’	1.3	2.0	3.1	1.5	1.8	-0.8
Overall health rating	1.6	3.3	8.2	1.0	1.0	-2.9
Chest pain or discomfort	1.9	2.7	3.4	-1.9	-1.6	1.5
Had major operations	0.1	0.1	0.2	-0.2	-0.3	-0.5
Age at last live birth	0.6	0.9	2.0	-1.4	-0.6	0.5
Family relationship satisfaction	0.2	0.3	0.4	-0.7	-0.6	0.1
Leg pain on walking	1.8	2.3	4.5	1.2	1.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	-0.4	-0.3	0.9
Commuting to job workplace: Car/motor vehicle	1.0	1.2	1.7	1.3	1.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.6	-1.1	-1.2	0.4
Medication: Aspirin	0.5	0.6	1.0	-0.5	-0.8	-1.0
Supplements: Vitamin C	1.5	1.7	3.3	1.8	1.2	-0.7
Knee pain experienced in last month	9.3	14.5	16.9	3.6	4.1	-3.7
Hypertension (Self-reported)	0.1	0.1	0.2	-0.5	-0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-1.1	-0.3	-0.2
Illnesses of father: Heart disease	0.7	1.0	1.9	-0.9	-1.4	0.5
Illnesses of siblings: Diabetes	0.6	0.8	1.0	-1.0	-1.0	0.7
Smoking status: Previous	0.2	0.2	0.3	0.1	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	0.0	1.0	-0.8
Whole body fat-free mass	1.3	7.3	10.3	3.2	3.2	-1.3
Leg fat-free mass (right)	1.2	6.6	8.8	2.8	3.0	-1.9
Arm fat percentage (left)	1.7	6.6	13.4	1.6	2.0	-3.7
Average weekly red wine intake	0.0	0.1	0.2	-0.2	-0.1	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.5	0.3	0.2
Mood swings	2.4	4.3	4.8	2.1	2.2	-1.9
Loneliness, isolation	1.6	2.2	2.9	1.6	1.7	-1.1
Long-standing illness, disability or infirmity	0.3	0.5	0.7	-0.9	-0.8	0.4
Ever had bowel cancer screening	0.4	0.5	1.3	-0.3	-0.4	1.1
Diabetes diagnosed by doctor	0.9	1.4	2.1	-1.3	-0.8	1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	3.5	-1.9	-1.5	1.4
Friendships satisfaction	0.3	0.4	0.9	1.0	0.2	-0.3
Qualifications: nursing, teaching	2.0	3.1	6.6	-1.2	-1.1	2.6
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.1	0.5
Eye problems/disorders: Cataract	0.3	0.3	0.4	-0.5	-0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	2.2	1.2	1.3	-1.5
Medication for cholesterol	0.7	1.0	2.5	-0.2	0.8	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.1	-0.7	-0.3
Back pain experienced in last month	1.4	2.0	2.2	1.4	1.4	-1.5
Mineral and other dietary supplements	6.9	9.3	10.2	-3.2	-2.9	3.0
Breast cancer (self-reported)	0.8	1.0	1.4	-0.5	-1.2	1.2
Asthma (self-reported)	0.9	1.7	2.2	-1.5	-1.3	1.1
Osteoporosis (self-reported)	0.5	0.7	1.7	0.3	-0.4	1.3
Osteoarthritis (self-reported)	1.4	1.8	2.6	1.6	0.9	-1.4
Medication: Aspirin	0.4	0.5	0.9	-0.5	-1.0	-0.6
Medication: Gliclazide	0.0	0.1	0.2	0.0	0.4	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	-0.4	-0.0
Smoking status: Current	1.8	2.9	4.3	-1.4	-1.5	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	0.4	-0.3
Whole body water mass	1.2	7.1	9.8	3.1	3.1	-1.3
Leg predicted mass (right)	1.2	6.3	8.6	2.7	2.9	-1.8
Arm fat mass (left)	2.2	9.0	12.1	2.6	2.8	-3.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.2	-0.3	-0.5	-0.4
Average weekly champagne plus white wine intake	0.8	1.1	1.8	-1.4	-0.9	0.8
Miserableness	0.0	0.1	0.1	-0.4	-0.1	-0.2
Guilty feelings	0.7	1.0	2.9	-0.2	0.4	-1.7
Wears glasses or contact lenses	0.4	0.5	0.7	-0.8	-0.8	0.5
Ever taken oral contraceptive pill	0.4	0.4	0.9	-0.9	-0.1	0.7
Hearing aid user	0.8	0.9	1.6	-0.5	-1.3	0.9
Mother’s age at death	0.1	0.1	0.2	-0.5	0.2	0.1
Financial situation satisfaction	0.8	1.0	1.4	0.8	1.0	-1.2
Tinnitus: Yes, now most or all of the time	5.1	5.9	6.9	-2.3	-2.6	2.3
Commuting to job workplace: Public transport	0.2	0.3	0.3	-0.6	-0.6	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.2	0.2	-1.0
Medication: Blood pressure	0.2	0.4	0.8	0.2	-0.9	0.6
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.4	1.4	1.2	-1.8
Supplements: Fish oil (including cod liver oil)	7.9	10.4	14.0	3.7	3.1	-2.7
High cholesterol (Self-reported)	1.1	2.0	5.4	-0.4	-0.6	-2.3
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.6	-0.1	-0.2
Medication: Paracetamol	1.7	2.6	3.1	1.3	1.8	-1.8
Medication: Lisinopril	0.5	0.6	1.3	-1.1	-0.7	0.2
Medication: Atorvastatin	0.4	0.5	0.6	-0.8	-0.6	-0.8
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.4	0.8	-1.1
Alcohol drinker status: Never	2.1	2.5	2.8	-1.7	-1.4	1.7
Ever smoked	0.4	0.6	1.0	0.7	1.0	-0.6
Basal metabolic rate	1.6	8.8	11.5	3.4	3.4	-1.9
Leg fat percentage (left)	2.2	8.0	11.7	2.6	2.3	-3.4
Arm fat-free mass (left)	1.8	9.2	13.9	3.7	3.4	-1.5
Number of operations (self-reported)	0.9	1.4	2.3	-1.4	-1.5	0.1
Average weekly beer plus cider intake	2.1	3.1	5.1	2.3	1.6	-1.3
Irritability	0.1	0.2	0.4	-0.6	-0.3	0.2
Risk taking	0.7	1.0	1.8	1.0	1.3	-0.4
Ever had prostate specific antigen (PSA) test	8.1	9.3	11.4	3.0	3.4	-2.7
Fractured/broken bones in last 5 years	0.9	1.2	3.0	0.6	0.4	-1.7
Age started oral contraceptive pill	0.5	0.6	0.9	0.6	0.8	-0.9
Diastolic blood pressure, automated reading	1.5	4.5	4.6	2.1	2.1	-2.1
Ever depressed for a whole week	0.8	1.0	1.7	-1.3	-1.0	0.5
Unable to work because of sickness or disability	0.8	1.0	1.5	-1.2	-1.2	-0.2
Commuting to job workplace: Cycle	0.9	1.1	1.3	-1.1	-1.0	0.9
Myopia	0.5	0.7	1.7	0.6	1.3	-0.0
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	-0.1	0.2	-0.3
Cholesterol lowering medication	0.1	0.1	0.1	0.3	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	5.7	0.7	1.2	-2.4
Pain experienced in last month	4.5	7.6	8.8	-2.5	-2.8	3.0
Supplements: Calcium	0.5	0.6	0.8	0.9	0.7	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.2	0.4	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	-1.2	-1.2	0.3
Deep venous thrombosis (DVT) (self-reported)	2.4	3.0	3.6	-1.4	-1.9	1.9
Heart disease (siblings)	0.1	0.1	0.3	0.0	-0.1	0.5
Alcohol drinker status: Previous	0.3	0.3	0.4	0.7	0.7	0.3
Pack years of smoking	2.3	3.3	3.8	-1.9	-1.7	1.8
Impedance of whole body	0.5	2.4	5.5	-2.4	-1.2	-0.7
Leg fat mass (left)	2.6	10.1	13.5	2.9	2.9	-3.7
Arm predicted mass (left)	1.9	9.8	14.2	3.8	3.5	-1.7