Hub : Genes

ATG14

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0280	0.0120	6.7e-04	0.019	0.023	0.016	0.022	0.016	2.1e-03	7.6e-04	3.6e-03	9.5e-04	4.4e-03
2	GTEx	Adipose Subcutaneous	0.0810	0.0290	2.5e-05	0.014	NA	0.057	NA	0.038	2.1e-02	NA	2.0e-05	NA	4.3e-04
3	GTEx	Artery Tibial	0.0507	0.0213	8.6e-04	0.057	NA	0.038	NA	0.035	3.0e-05	NA	5.3e-04	NA	8.3e-04
4	GTEx	Cells Transformed fibroblasts	0.0970	0.0380	7.1e-05	0.013	NA	0.020	NA	0.023	3.3e-02	NA	1.1e-02	NA	7.3e-03
5	GTEx	Esophagus Mucosa	0.1290	0.0350	1.7e-09	0.131	NA	0.159	NA	0.172	4.9e-09	NA	8.8e-11	NA	1.2e-11
6	GTEx	Muscle Skeletal	0.0797	0.0306	7.5e-05	0.027	NA	0.029	NA	0.012	1.1e-03	NA	6.5e-04	NA	2.1e-02
7	GTEx	Nerve Tibial	0.0571	0.0271	6.3e-03	0.016	NA	-0.003	NA	-0.002	2.3e-02	NA	6.1e-01	NA	4.7e-01
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1260	0.0470	2.3e-04	0.077	NA	0.047	NA	0.065	4.8e-05	NA	1.4e-03	NA	1.8e-04
9	GTEx	Skin Sun Exposed Lower leg	0.1010	0.0300	4.5e-09	0.104	NA	0.144	NA	0.154	5.7e-09	NA	6.2e-12	NA	1.0e-12
10	GTEx	Testis	0.1240	0.0450	5.9e-05	0.161	NA	0.123	NA	0.150	1.2e-07	NA	4.4e-06	NA	3.4e-07
11	METSIM	Adipose	0.0521	0.0200	1.9e-05	0.062	0.028	0.064	0.035	0.065	1.4e-09	3.6e-05	6.3e-10	4.3e-06	4.5e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.3	1.4	-0.3	0.1	-0.3	0.2	0.6	-0.2	0.8	0.5	0.8	0.3	-1.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.5	-0.0	-0.5	-0.2	-0.3	-0.1	-0.3	0.1	0.0	-0.2	0.0
Depressed Affect (Nagel 2018)	0.1	0.2	1.0	0.6	-1.0	-0.1	0.0	0.1	0.4	-0.1	-0.2	0.2	-0.2	-0.5
Depression (Nagel 2018)	0.5	0.8	1.6	1.3	-1.2	-0.9	-0.7	-0.6	-0.3	-0.8	-0.8	-1.2	-0.8	0.6
Intelligence (Savage-Jansen 2018)	1.8	5.7	9.3	2.9	-2.6	-1.4	-2.7	-2.8	-1.4	-2.1	-2.3	-3.1	-2.8	1.3
Neuroticism (Nagel 2018)	0.3	0.8	1.4	0.2	-0.5	0.8	1.1	1.1	1.1	0.9	0.8	0.5	0.9	-1.2
Schizophrenia (2018)	0.2	0.4	1.1	0.9	-0.1	-0.4	-0.4	-0.9	0.1	-1.0	-0.2	-0.6	-0.6	1.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.2	0.4	0.1	0.1	0.0	0.8	-0.8	0.2	-0.5	0.3	0.1
Worry (Nagel 2018)	1.7	3.6	6.4	-1.0	0.8	1.7	1.8	2.4	2.2	1.5	2.2	1.5	2.2	-2.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	-0.2	-0.5	0.8	0.2	0.8	0.5	1.3	0.4	-0.2	0.6	-0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.6	-0.8	-0.4	-0.4	-0.0	-0.5	0.8	-0.1	-0.3	0.0	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	2.6	0.0	-1.0	0.1	-0.1	0.7	0.1	1.6	0.3	-0.2	0.6	-0.7
Crohns Disease (2017)	0.9	1.9	4.7	-1.3	1.7	1.5	1.8	1.1	-0.1	2.2	1.1	1.3	1.3	0.4
Irritable Bowel Disease (IBD)	0.8	1.8	4.4	-1.4	1.4	1.3	1.8	1.3	-0.2	2.1	1.1	1.3	1.4	0.1
Ulcerative Colitis (UC)	0.2	0.4	1.1	-0.7	0.5	0.4	0.8	0.7	-0.0	1.1	0.5	0.8	0.8	-0.4
Major Depression (MDD)	0.2	0.3	0.9	0.2	-0.8	0.5	0.5	0.1	0.1	0.2	0.2	-0.6	0.6	0.9
Reaction Time	1.0	2.0	5.4	2.3	-2.1	-1.1	-1.8	-0.9	-0.3	0.4	-1.2	-1.2	-1.2	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.6	1.5	-1.2	-0.4	-1.4	-1.6	-1.2	-0.4	-1.2	-1.5	-1.3	1.6
Breast Cancer	0.0	0.1	0.2	-0.0	-0.4	0.3	-0.3	0.3	-0.0	-0.4	-0.4	-0.2	-0.2	0.4
Ovarian Cancer	0.3	0.4	2.1	-0.2	0.1	0.8	0.6	0.0	-0.1	1.5	0.2	0.4	0.2	1.1
Prostate Cancer	1.0	1.3	2.4	-0.9	1.5	1.5	1.3	1.1	1.3	0.3	1.1	1.4	1.1	-0.3
Age at First Birth	1.5	2.2	3.8	1.6	-1.7	-1.9	-1.9	-1.4	-0.7	-0.5	-1.6	-1.6	-1.8	0.0
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.3	-0.5	-0.0	-0.4	-0.1	0.1	0.1	-0.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.3	-1.1	1.5	0.8	0.8	1.2	1.2	0.5	1.3	1.0	1.1	-1.1
Coronary Artery Disease (CAD)	0.4	0.4	2.9	-0.2	0.8	-0.6	-0.5	-0.5	-0.1	-1.7	-0.4	-0.2	-0.4	0.1
Crohns Disease (2012)	0.1	0.2	0.7	-0.5	0.6	0.5	0.8	0.1	-0.2	0.7	0.2	-0.0	0.1	0.5
Mean Putamen Volume	0.9	1.1	3.5	-1.9	1.3	1.3	0.7	-0.1	-1.2	-1.0	0.8	0.7	0.5	-0.5
Fasting Glucose	0.3	0.3	1.0	0.6	0.0	-1.0	0.3	-0.7	-0.4	0.2	-0.7	-0.6	-0.7	-0.2
HbA1C	0.4	0.4	1.5	0.7	0.0	-0.1	-1.0	-0.1	0.3	1.2	-0.2	0.3	-0.2	1.1
HDL Cholesterol	0.2	0.3	0.6	-0.4	-0.3	0.7	0.4	0.5	0.2	0.6	0.4	0.5	0.5	-0.8
LDL Cholesterol	0.2	0.3	0.5	0.4	-0.7	0.1	-0.7	-0.6	-0.4	-0.6	-0.6	-0.2	-0.6	-0.0
Lupus	0.4	0.7	2.4	0.4	-0.4	-0.1	-0.1	-1.1	-0.6	-1.2	-0.9	0.2	-0.8	1.6
Neuroticism (2016)	1.2	1.8	5.8	-0.3	-0.1	1.3	0.8	1.5	2.4	0.6	1.2	1.5	1.2	-1.9
Primary Biliary Cirrhosis	1.5	2.1	6.4	-0.8	0.5	0.8	1.5	1.6	1.6	2.5	1.5	1.0	1.5	-1.4
Rheumatoid Arthritis	0.5	0.7	4.5	-0.2	-0.5	-0.4	0.2	0.9	0.9	-0.5	0.4	1.0	0.1	-2.1
Schizophrenia (2014)	0.1	0.2	0.5	0.6	0.1	-0.7	-0.5	-0.4	0.5	-0.7	0.1	-0.4	-0.3	-0.1
Triglycerides	0.2	0.3	0.8	0.4	-0.6	-0.8	-0.5	-0.4	-0.6	-0.5	-0.3	-0.9	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.0	-0.2	-0.1	0.4	-0.0	0.4	1.4	0.1	0.7	0.5	0.3	-0.8
Ulcerative Colitis	0.2	0.4	1.0	-0.6	0.2	-0.0	0.5	1.0	0.1	0.3	0.6	0.4	0.8	-1.0
Blood Eosinophil Count	9.5	73.2	95.3	9.5	-8.0	-9.6	-9.4	-9.3	-7.1	-5.6	-9.8	-8.6	-9.7	6.2
Blood Platelet Count	4.5	51.6	78.3	8.4	-7.4	-8.8	-8.3	-7.2	-5.0	-2.9	-8.0	-7.9	-8.1	4.3
Blood Red Count	1.6	15.2	20.6	4.1	-4.5	-4.5	-4.3	-3.9	-3.8	-1.6	-4.0	-4.5	-4.2	2.1
Blood White Count	3.5	26.1	58.6	5.5	-3.9	-3.4	-4.6	-5.9	-4.1	-2.1	-5.6	-6.0	-5.2	7.7
Heel T-Score	0.3	2.1	4.2	1.5	-0.9	-0.9	-1.4	-2.0	-1.6	0.3	-1.6	-1.5	-1.6	1.7
BMI	2.4	13.7	18.2	-4.2	3.9	4.3	4.2	3.7	2.6	4.0	4.0	3.4	4.2	-0.7
Height	0.2	4.2	31.9	0.6	-1.1	-2.0	-1.1	1.2	-0.2	-1.8	1.2	0.9	0.6	-5.7
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.2	0.8	0.8	0.3	0.5	-0.1	-0.6	0.4	0.4	0.6	0.8
Systolic Blood Pressure	0.9	4.6	8.7	1.2	-1.8	-2.9	-1.9	-2.1	-2.2	-0.2	-2.9	-2.5	-2.7	1.7
Smoking Status	0.2	0.6	2.8	0.4	-0.0	0.3	-0.5	-0.7	-1.2	-0.3	-0.8	-0.4	-0.5	1.7
Allergy or Eczema	0.7	1.7	2.5	1.5	-1.6	-1.4	-1.3	-1.2	-1.6	-1.4	-1.3	-1.3	-1.2	-0.2
Cardiovascular Disease	0.3	0.9	2.8	-1.3	0.9	0.3	0.6	1.0	1.1	1.7	0.8	0.9	0.7	0.2
Hypothyroidism (self reported)	3.4	7.8	10.6	2.4	-1.9	-3.2	-3.0	-3.2	-2.6	-3.0	-3.2	-2.4	-3.1	2.1
Respiratory disease	0.1	0.3	1.8	0.3	-1.3	-0.2	-0.3	-0.1	-0.7	-0.7	-0.2	0.0	-0.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	0.9	-1.4	-0.5	-1.3	-1.1	-1.5	-1.0	-1.1	-0.9	-1.0	0.6
Lung FEV1/FVC ratio	1.0	5.2	15.3	2.5	-2.6	-3.9	-2.6	-1.7	-1.3	-1.6	-1.9	-2.2	-2.4	-1.1
Lung FVC	0.1	0.6	3.3	-0.5	0.8	0.6	0.2	-0.3	0.5	-0.7	-0.2	0.9	-0.1	1.8
Neuroticism	0.5	1.2	4.7	0.3	-1.2	0.4	0.7	1.2	1.6	0.6	0.9	0.5	0.8	-2.2
Chronotype (morning person)	1.8	4.1	9.1	2.7	-1.7	-1.8	-1.8	-2.4	-1.5	-1.1	-2.0	-3.0	-1.8	1.7
Hair Pigment	0.0	1.2	2.9	-1.6	1.7	1.4	0.8	0.5	1.3	-0.9	0.8	0.9	0.6	1.1
Tanning	0.4	5.0	11.0	-3.2	2.1	3.3	3.0	2.0	0.0	2.0	1.7	2.2	2.1	-0.8
Hand grip strength (left)	0.2	0.6	2.0	-0.2	1.0	-1.4	-0.1	-0.8	-1.0	-0.1	-0.5	-0.5	-0.6	1.1
Number of treatments/medications taken	0.8	1.5	2.3	-1.4	1.2	1.4	0.9	1.5	0.8	-0.0	1.5	1.3	1.4	-1.1
Average weekly spirits intake	2.5	3.1	5.3	-1.9	1.3	2.3	1.8	2.2	1.2	2.0	1.7	1.8	1.9	-0.0
Sensitivity / hurt feelings	0.5	0.8	2.1	-0.0	-0.3	1.4	1.3	1.2	1.0	0.1	0.8	-0.1	0.9	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.8	0.5	-0.6	-0.1	-0.2	0.5	0.4	-0.1	-0.7	-0.0	1.2
Hearing difficulty/problems: Yes	0.6	0.9	2.7	0.6	-1.4	-0.4	-1.3	-0.8	-1.6	-0.4	-1.0	0.0	-0.9	0.7
Relative age of first facial hair	0.8	1.7	4.4	1.1	-1.2	-1.4	-1.0	-1.3	-2.1	-0.7	-1.5	-1.2	-1.5	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.7	0.0	-0.2	0.3	-0.3	-0.7	0.5	-0.6	-0.3	0.0	-0.2	1.3
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.8	1.4	-0.7	-1.4	-1.1	-1.5	-1.8	-1.5	-1.6	-1.1	-1.4	1.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	-0.8	0.3	0.1	0.1	0.3	-0.9	0.2	0.2	0.4	0.3	0.1
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.5	-0.0	-0.9	0.1	-0.1	-0.8	0.1	-0.8	-0.4	-0.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-0.9	0.9	0.4	0.9	1.1	1.1	0.1	1.2	0.4	1.0	-1.1
Angina	0.5	0.6	3.0	0.3	-1.1	-0.2	-0.4	-1.2	-0.0	-1.7	-0.6	-0.3	-0.7	-0.5
Medication for hormone replacement therapy	1.3	1.4	5.3	0.9	-0.4	-0.5	-0.6	-1.7	-1.3	-1.2	-0.8	-1.3	-0.9	2.3
Vitamin and mineral supplements	11.8	16.0	21.8	4.2	-3.2	-4.7	-4.4	-4.4	-3.6	-2.4	-4.6	-3.8	-4.4	3.7
Supplements: Zinc	0.0	0.0	0.2	-0.3	-0.2	-0.2	-0.4	-0.2	0.3	0.2	-0.1	-0.0	-0.1	0.2
Medication: Co-codamol	0.7	0.8	1.8	-0.6	0.1	1.3	0.7	1.0	1.1	0.7	1.2	0.8	1.3	-0.1
Medication: Metformin	1.0	1.4	2.1	0.9	-1.4	-0.4	-1.4	-1.4	-1.3	-1.2	-1.2	-0.8	-1.1	1.3
Diabetes (father)	0.1	0.1	0.3	0.2	-0.0	-0.2	-0.3	0.4	-0.4	-0.5	0.4	-0.2	0.4	-0.3
Diabetes (mother)	0.7	0.8	2.9	-1.0	0.5	1.7	0.6	0.7	0.8	-0.1	0.9	1.2	0.9	-0.8
Severe depression (siblings)	1.2	1.3	3.2	1.4	-0.4	-1.3	-1.2	-1.1	-0.7	-1.8	-1.0	-1.2	-1.1	0.6
Pack years adult smoking proportion	5.3	8.0	10.9	2.9	-2.4	-3.0	-3.3	-3.2	-2.0	-2.2	-3.2	-2.8	-3.2	2.6
Impedance of leg (right)	0.2	1.1	2.9	1.4	-1.7	-1.1	-1.4	-0.7	-0.6	-0.6	-0.9	-1.1	-1.0	0.1
Leg fat-free mass (left)	1.1	5.7	7.6	-2.7	2.7	2.3	2.3	2.4	2.2	1.7	2.7	2.4	2.8	-1.8
Trunk fat percentage	1.1	4.6	6.6	-2.2	1.8	2.6	2.0	2.2	2.4	2.0	2.3	2.4	2.4	-0.3
Hand grip strength (right)	0.2	0.5	2.5	-0.2	0.4	-1.6	-0.4	-0.7	-0.2	-0.9	-0.7	-0.5	-1.0	-0.1
Townsend deprivation index at recruitment	0.6	0.8	1.7	-0.4	0.6	1.2	0.9	0.8	0.8	0.9	1.0	1.3	1.0	0.5
Current tobacco smoking	1.2	2.0	3.2	1.5	-0.6	-1.2	-1.5	-1.5	-1.5	-1.2	-1.4	-1.6	-1.5	1.8
Average weekly fortified wine intake	0.6	0.7	1.6	1.3	-1.2	-0.3	-0.7	-0.6	-0.3	0.9	-0.5	-1.2	-0.5	0.7
Maternal smoking around birth	0.8	1.1	2.1	0.8	-0.3	-1.5	-1.3	-0.8	-1.4	-0.7	-1.3	-0.7	-1.1	1.3
Fed-up feelings	1.0	1.8	2.7	-1.1	0.5	1.2	1.1	1.5	1.6	1.5	1.5	1.6	1.6	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.6	-0.5	-0.5	-0.5	-0.4	-0.7	-0.5	-0.5	-0.8	-0.4	0.9
Relative age voice broke	1.3	2.0	3.4	1.6	-1.5	-1.6	-1.1	-1.2	-1.8	-0.0	-1.8	-1.4	-1.7	0.7
Taking other prescription medications	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.1	-0.0	-0.5	-0.3	0.1	0.2	0.1	0.1
Age when periods started (menarche)	1.0	2.4	6.9	2.6	-2.0	-1.4	-1.6	-1.3	0.1	-0.5	-1.7	-1.5	-1.7	0.9
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	6.4	1.6	-1.8	-1.1	-1.2	-2.0	-2.5	-1.5	-1.8	-1.7	-1.6	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	5.1	1.9	-0.9	-1.4	-1.5	-1.8	-0.9	-0.0	-2.0	-2.3	-1.9	2.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	5.1	1.7	-1.5	-1.5	-2.2	-1.9	-0.7	-2.1	-1.6	-1.4	-1.9	0.7
Qualifications: CSEs or equivalent	0.8	1.0	1.6	-0.9	1.1	1.1	1.2	1.2	0.9	0.0	1.2	0.7	1.1	-1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-1.1	0.7	1.2	0.9	0.7	0.6	-0.0	0.4	0.8	0.8	0.4
High blood pressure	0.3	0.7	1.9	-0.8	1.2	0.9	0.7	0.4	1.0	1.4	0.5	0.7	0.6	1.0
Hayfever, allergic rhinitis or eczema	1.8	3.8	6.0	1.9	-1.5	-2.4	-1.8	-2.0	-2.1	-2.5	-1.9	-2.1	-2.1	-0.3
Multivitamins +/- minerals	6.5	8.2	11.3	-3.2	2.2	3.4	2.7	3.1	2.3	2.2	3.3	2.7	3.2	-2.9
Stomach or abdominal pain in last month	0.6	0.7	2.9	-0.7	-0.0	1.7	1.2	0.7	0.3	0.2	1.1	0.6	1.1	-0.1
Supplements: Glucosamine	9.3	12.1	17.1	-3.2	3.5	2.9	3.3	3.7	4.1	1.2	4.1	3.9	3.9	-3.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.2	2.2	-1.0	1.0	0.9	0.9	1.4	1.5	1.1	1.4	1.0	1.3	-0.2
Medication: Atenolol	0.4	0.5	1.6	0.0	-0.2	0.3	0.1	-0.3	-1.1	1.2	-0.5	-0.2	-0.3	1.3
Medication: Levothyroxine sodium	2.4	4.1	5.8	1.8	-1.7	-2.3	-2.1	-2.3	-2.4	-1.5	-2.2	-2.0	-2.2	1.5
Sitting height	0.3	2.0	5.8	-1.4	0.9	0.9	1.0	1.5	1.3	0.8	1.8	1.1	1.7	-2.4
Chronic bronchitis/emphysema (father)	1.3	1.6	5.0	-1.3	0.2	1.4	1.8	1.0	1.1	2.2	1.2	0.5	1.1	-0.7
High blood pressure (mother)	2.2	3.0	7.1	-2.7	2.4	2.3	1.9	1.1	0.7	0.6	1.6	1.9	1.8	-0.5
Body mass index (BMI)	2.1	8.8	14.9	-3.6	2.9	3.9	3.3	2.7	2.1	3.2	2.9	2.8	3.3	0.1
Impedance of leg (left)	0.2	1.0	2.2	1.3	-1.5	-1.0	-1.2	-0.7	-0.5	-0.7	-0.8	-1.1	-1.0	0.0
Leg predicted mass (left)	1.1	5.7	7.6	-2.7	2.7	2.3	2.2	2.4	2.3	1.7	2.7	2.4	2.8	-1.7
Trunk fat mass	1.4	6.1	7.9	-2.8	2.3	2.8	2.3	2.6	2.6	2.1	2.7	2.7	2.8	-1.0
Waist circumference	1.0	3.7	5.7	-2.3	1.9	2.4	2.0	1.7	1.3	1.8	2.0	2.1	2.2	-0.3
Number of incorrect matches in round	2.3	3.8	5.9	-1.7	0.3	1.9	2.4	2.4	1.4	2.4	2.3	1.6	2.2	-1.7
Past tobacco smoking	0.1	0.1	0.6	-0.1	0.3	-0.8	0.3	0.3	-0.1	0.2	0.1	-0.0	-0.1	-0.6
Alcohol usually taken with meals	0.3	0.4	1.8	0.6	-0.2	-0.9	-0.1	-0.8	0.3	-1.4	-0.3	-0.4	-0.6	-0.6
Nervous feelings	1.2	2.3	10.9	-0.9	0.1	0.6	1.3	1.9	1.5	-0.0	1.6	0.7	1.5	-3.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.1	0.9	0.5	0.6	-0.1	0.8	0.2	0.4	0.5	0.7	0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.8	-0.8	-0.5	-1.0	0.0	0.1	-0.8	0.1	0.2	-0.0	-0.8
Hair/balding pattern: Pattern 2	2.9	3.6	6.7	-2.6	2.5	1.6	2.5	2.1	1.1	2.0	1.9	1.3	1.7	-0.7
Had menopause	0.4	0.6	1.3	0.6	-0.8	-1.0	-0.6	-0.4	-1.1	-1.1	-0.5	-0.3	-0.6	-0.4
Had other major operations	0.3	0.3	1.3	0.5	0.6	-0.5	-0.2	-0.5	-0.3	-0.6	-0.6	0.2	-0.6	1.1
Forced vital capacity (FVC)	0.7	2.7	7.4	-1.9	1.9	0.6	1.1	1.5	1.5	-0.7	1.5	1.9	1.4	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.5	1.6	-0.8	-0.4	-0.9	-1.1	-1.0	1.0	-1.4	-1.9	-1.2	2.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.5	0.3	0.0	-0.4	-0.4	-0.5	0.2	-0.4	-0.2	-0.2	-0.1	1.2
Qualifications: None of the above	0.9	1.9	3.9	-1.1	0.4	1.3	0.9	1.9	2.0	1.1	1.4	1.3	1.4	-1.5
Financial difficulties in last 2 years	0.2	0.3	1.0	-0.1	-0.0	0.9	-0.0	0.2	0.4	1.0	0.4	-0.0	0.7	0.7
Mouth/teeth dental problems	0.2	0.4	0.9	-0.9	1.0	-0.2	0.3	0.5	0.5	0.6	0.6	0.3	0.6	-0.9
Heart attack	0.3	0.4	0.8	0.8	-0.4	-0.4	-0.1	-0.7	0.5	-0.0	-0.5	-0.9	-0.6	0.9
Allergy	1.8	4.1	6.3	-2.0	2.2	2.5	2.0	2.0	2.0	2.4	1.9	2.0	2.1	0.3
Pain all over the body in last month	4.5	4.8	7.6	-2.4	1.6	2.7	2.5	2.8	1.8	1.1	2.2	2.4	2.5	-1.5
Diabetes (self-reported)	1.7	2.6	3.7	1.7	-1.9	-1.0	-1.8	-1.8	-1.8	-1.5	-1.7	-1.4	-1.7	1.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.8	-0.4	-0.6	-0.5	0.0	-0.1	-0.5	-0.7	-0.4	-0.4	-0.2	-1.3
Medication: Ramipril	1.8	2.3	5.5	1.1	-0.4	-1.5	-1.4	-1.9	-0.8	-1.4	-1.9	-1.2	-1.8	2.3
Medication: Simvastatin	0.3	0.4	0.8	-0.7	0.7	0.5	-0.0	0.4	0.4	0.9	0.7	0.9	0.6	0.4
Fluid intelligence score	0.7	1.5	2.2	1.3	-1.0	-1.1	-1.4	-1.5	-1.3	-0.6	-1.2	-1.3	-1.4	1.2
Illnesses of siblings	0.2	0.3	0.5	-0.4	0.7	0.7	0.5	0.5	0.6	-0.3	0.7	0.5	0.7	-0.4
Neuroticism score	0.6	1.2	2.4	0.1	-0.4	1.1	1.3	1.4	1.6	1.1	1.2	0.5	1.2	-1.3
Weight	2.2	10.8	14.9	-3.8	3.2	3.5	3.4	3.4	2.8	2.8	3.7	3.2	3.9	-2.0
Impedance of arm (right)	1.7	8.1	16.6	4.1	-3.9	-3.3	-3.3	-2.4	-1.0	-2.5	-2.7	-2.5	-2.9	0.8
Arm fat percentage (right)	1.2	4.7	7.2	-2.4	1.7	2.7	2.1	2.0	2.3	2.4	2.2	2.2	2.5	0.2
Trunk fat-free mass	1.1	6.5	9.2	-3.0	3.0	2.1	2.4	2.6	1.5	2.0	3.0	2.3	3.0	-2.8
Hip circumference	0.9	3.8	5.8	-2.4	1.6	2.0	2.0	1.8	1.8	2.2	2.1	1.9	2.2	-1.0
Time employed in main current job	3.0	3.4	7.1	-1.4	0.9	2.2	2.1	2.0	1.0	2.7	1.9	2.0	2.1	-1.3
Alcohol intake versus 10 years previously	0.2	0.3	1.1	-0.2	-0.1	0.8	0.3	0.2	-0.0	1.0	-0.0	-0.6	0.3	1.0
Father’s age at death	0.4	0.6	4.9	0.1	-0.8	-0.5	0.1	0.5	0.2	-0.3	0.2	-0.1	-0.2	-2.2
Worrier / anxious feelings	1.0	1.8	3.9	-0.7	1.0	1.0	1.4	1.8	1.9	2.0	1.4	0.7	1.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	1.2	-0.6	-0.7	-1.1	-0.6	-1.1	-0.6	-0.5	-0.6	-0.4	0.3
Falls in the last year	0.7	1.0	2.3	-1.2	1.5	1.3	1.0	0.8	-0.4	0.2	0.9	0.8	1.2	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	2.6	0.6	-1.5	-0.1	-0.4	-0.6	0.1	-1.6	-0.0	0.1	-0.2	-1.1
Number of live births	1.1	1.6	2.9	1.2	0.3	-1.4	-1.3	-1.7	-0.9	-1.4	-1.1	-0.8	-1.3	1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	6.3	-1.2	1.2	-0.2	0.5	0.7	0.9	-1.2	0.7	1.1	0.6	-2.5
Pulse rate	3.0	5.1	10.8	-2.5	3.3	2.6	2.8	2.0	2.0	0.2	2.4	2.2	2.2	-1.0
Happiness	0.2	0.2	0.6	-0.3	0.0	-0.8	0.1	0.6	0.5	-0.4	0.3	-0.3	0.3	-0.7
Noisy workplace	0.4	0.6	1.9	-1.1	1.0	0.9	0.2	-0.1	-0.4	-0.6	-0.0	0.7	0.3	1.4
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.5	1.1	-1.4	-1.3	-1.5	-1.7	-2.3	-1.7	-1.4	-0.8	-1.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	-0.8	1.2	1.4	0.7	0.5	1.1	-0.1	0.9	1.0	0.9	0.2
Mouth/teeth dental problems: Dentures	0.3	0.6	3.5	0.1	-0.2	0.5	-0.1	-0.5	-1.4	-0.4	-0.5	-0.0	-0.3	1.9
Asthma	1.0	1.9	3.5	1.3	-1.9	-1.1	-1.3	-1.5	-1.8	-1.5	-1.3	-1.0	-1.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	7.5	-2.0	1.5	1.6	1.3	2.3	2.3	0.8	2.2	2.0	2.2	-2.7
Medication: Cholesterol lowering	0.2	0.3	1.7	-0.2	0.7	0.1	-0.3	-0.6	-0.2	-0.7	-0.2	0.6	-0.2	1.3
Depression (self-reported)	0.5	0.6	1.2	-0.7	0.3	1.0	0.5	1.0	0.2	0.8	1.1	0.4	1.1	-0.8
Medication: Lansoprazole	0.4	0.5	1.1	-0.7	0.1	1.1	0.9	1.0	0.1	0.5	0.7	0.6	0.9	-0.4
Prospective memory result	0.4	0.4	1.4	-0.8	0.9	-0.4	0.5	0.5	-0.7	1.2	-0.0	0.7	0.2	-0.5
Lung cancer (father)	1.4	1.6	3.3	1.6	-1.4	-0.7	-1.3	-1.1	-0.6	0.1	-1.4	-1.6	-1.2	1.8
Illnesses of mother	1.8	2.2	5.2	1.4	-0.7	-2.3	-1.4	-1.5	-1.2	-1.9	-1.4	-1.4	-1.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	8.3	-2.0	1.9	0.1	1.3	1.6	1.0	-0.3	1.3	1.7	1.4	-2.9
Pulse wave Arterial Stiffness index	2.7	3.1	6.1	-1.9	2.4	1.7	1.6	1.6	1.6	0.8	1.6	2.5	1.6	-1.5
Impedance of arm (left)	1.6	7.4	15.1	3.9	-3.4	-3.4	-3.1	-2.3	-0.8	-2.6	-2.5	-2.4	-2.9	0.5
Arm fat mass (right)	2.0	8.2	11.3	-3.4	2.8	3.3	2.9	2.8	2.6	2.8	3.1	2.8	3.4	-0.7
Trunk predicted mass	1.2	6.6	9.4	-3.1	3.0	2.1	2.4	2.6	1.5	2.0	3.0	2.3	3.0	-2.8
Standing height	0.3	3.0	18.9	-0.7	0.9	-0.7	0.3	1.7	1.3	-0.3	1.9	1.1	1.5	-4.3
Length of working week for main job	0.2	0.2	1.2	-0.5	-0.1	1.1	0.3	0.1	-0.1	-0.6	0.4	0.1	0.4	0.3
Exposure to tobacco smoke at home	0.5	0.6	2.7	0.3	-0.3	0.2	-0.9	-0.4	1.7	-1.5	-0.1	-0.0	-0.2	0.3
Breastfed as a baby	1.6	2.0	3.9	-1.4	1.5	0.6	0.5	1.5	1.6	1.3	1.6	1.8	1.2	-2.0
Tense / ‘highly strung’	3.3	5.4	7.5	-1.8	1.5	2.4	2.6	2.6	2.3	2.7	2.7	1.7	2.6	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.5	-0.7	0.9	0.7	1.1	0.9	-0.3	0.8	1.1	0.5	1.2	0.1
Hair/balding pattern: Pattern 4	2.1	5.2	8.6	2.7	-2.1	-2.4	-2.3	-2.4	-2.1	-1.4	-2.3	-2.9	-2.4	1.6
Birth weight of first child	1.7	3.0	6.3	-1.9	1.2	2.5	1.6	1.9	1.4	0.9	1.7	2.4	1.5	-1.8
Peak expiratory flow (PEF)	0.4	1.0	4.6	-0.8	0.7	-1.2	-0.1	0.1	0.3	-1.6	0.1	0.8	-0.1	-2.1
Pulse wave reflection index	0.3	0.3	1.3	-0.8	0.2	0.0	0.1	0.2	0.9	0.2	0.2	1.0	0.2	-1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.7	-1.6	1.6	0.8	0.4	0.9	0.8	0.7	1.4	1.3	1.2	-0.4
Loud music exposure frequency	0.5	0.6	1.7	0.9	-0.2	-0.9	-1.3	-0.7	-0.2	-0.9	-0.6	-0.8	-0.6	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.1	1.2	-0.9	-1.2	-1.5	-1.8	-1.7	-0.6	-1.6	-1.2	-1.3	1.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	0.7	-0.5	0.0	-0.1	0.3	0.8	0.2	0.2	0.2	0.2	-0.4
Blood clot in the leg (DVT)	0.9	1.2	2.8	0.6	-0.0	-1.1	-1.2	-1.6	-0.9	-1.7	-1.1	-0.4	-1.1	1.0
Medication: Paracetamol	0.4	0.7	1.4	-0.6	0.5	1.1	0.3	0.9	1.2	1.0	0.9	0.6	1.2	-0.1
Headache pain in last month	0.9	1.5	3.2	-1.0	1.2	1.6	1.4	1.2	0.6	0.8	1.8	0.8	1.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	0.9	-0.9	-0.9	-0.1	-0.2	-0.5	0.2	-0.4	-1.1	-0.4	-0.4
Glaucoma (self-reported)	0.2	0.2	0.8	0.6	-0.7	-0.3	0.2	0.5	0.3	0.1	-0.0	-0.2	-0.1	-0.9
Gout (self-reported)	1.5	2.1	4.0	1.5	-1.1	-1.5	-1.6	-1.6	-1.2	-1.1	-1.4	-2.0	-1.2	1.1
Hypothyroidism/myxoedema (self-reported)	4.5	8.8	11.7	2.5	-2.5	-3.2	-3.1	-3.4	-3.2	-2.8	-3.4	-2.5	-3.3	2.3
Medication: Amlodipine	0.4	0.6	1.6	-1.3	0.0	1.0	0.8	0.9	0.5	0.1	0.7	0.6	0.7	-1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	-0.4	-0.5	0.5	0.6	0.4	-0.7	0.4	0.1	0.3	0.3	0.1
Birth weight	0.2	0.4	1.3	0.8	0.3	-1.1	-0.1	-0.8	-0.8	-0.3	-0.7	-0.5	-0.8	0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.7	-0.5	0.0	0.7	0.9	0.5	-1.2	1.6	-0.1	0.1	0.2	1.5
High blood pressure (siblings)	0.1	0.2	0.5	0.0	-0.5	-0.3	-0.1	-0.4	-0.7	0.5	-0.6	-0.2	-0.6	0.3
Forced vital capacity (FVC), Best measure	1.1	3.8	8.5	-2.4	2.4	0.8	1.6	2.0	1.6	-0.3	1.9	2.3	1.9	-2.9
Body fat percentage	1.6	6.2	9.8	-2.8	2.1	3.1	2.4	2.5	2.6	2.4	2.6	2.6	2.8	-0.3
Leg fat percentage (right)	2.4	8.7	15.9	-3.5	2.4	4.0	3.0	2.8	2.7	3.2	3.0	2.8	3.4	0.1
Arm fat-free mass (right)	1.9	9.5	14.4	-3.8	3.8	2.9	3.0	3.2	2.1	2.4	3.5	2.8	3.5	-2.6
Exposure to tobacco smoke outside home	0.2	0.3	1.5	-0.2	-0.8	-0.6	-0.3	0.4	0.1	-0.6	0.1	-0.5	0.2	-1.2
Comparative body size at age 10	0.4	1.0	2.8	-0.8	1.2	1.0	0.9	0.7	1.7	0.5	1.3	0.1	1.1	-0.8
Number of full brothers	0.4	0.4	1.6	0.1	0.6	-0.9	-0.5	0.3	0.9	1.3	0.1	-0.1	0.3	1.0
Worry too long after embarrassment	0.4	0.7	1.5	0.4	0.4	0.7	1.2	1.1	0.8	0.6	1.1	0.2	1.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.7	0.1	0.8	-0.3	0.3	0.1	-0.6	0.0	-0.0	-0.1	0.2	0.6
Wheeze or whistling in the chest in last year	1.1	1.9	4.3	1.5	-2.1	-0.7	-1.1	-1.9	-1.2	-1.3	-1.2	-1.0	-1.3	1.4
Number of children fathered	0.5	0.6	5.0	-0.0	1.0	0.3	-0.1	-0.3	0.2	-0.5	0.1	0.4	0.1	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	2.5	-0.7	0.9	1.1	1.2	1.1	1.6	1.4	1.2	0.6	1.2	-0.8
Age at first live birth	1.2	2.1	3.5	1.4	-1.5	-1.8	-1.9	-1.5	-0.9	-1.7	-1.3	-1.2	-1.6	-0.6
Pulse wave peak to peak time	2.3	2.8	5.6	1.9	-2.4	-1.6	-1.6	-1.4	-1.4	-0.7	-1.5	-2.4	-1.5	1.1
Health satisfaction	2.4	3.1	6.4	-1.6	2.5	1.7	1.5	1.9	1.8	0.8	2.0	1.8	2.2	0.4
Shortness of breath walking on level ground	0.1	0.2	1.0	0.0	-0.2	-0.1	-0.2	0.0	-1.0	0.2	-0.3	0.1	-0.1	0.8
Qualifications: College or University degree	1.2	3.7	6.2	1.8	-1.7	-2.1	-1.9	-2.5	-1.4	-2.1	-2.2	-1.7	-2.3	1.4
Eye problems/disorders: None of the above	0.6	0.7	2.9	0.5	-0.1	-0.4	-0.4	-0.8	-0.8	0.6	-0.9	-0.9	-0.7	1.7
Mouth/teeth dental problems: Loose teeth	1.7	2.1	5.5	1.6	-1.2	-1.1	-1.2	-1.6	-1.1	-0.7	-1.4	-1.6	-1.2	2.4
Emphysema/chronic bronchitis	2.2	2.5	6.6	1.7	-2.6	-1.2	-1.7	-1.5	-1.4	-1.8	-1.9	-0.8	-1.4	0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	3.6	1.5	-1.4	-1.6	-1.0	-1.9	-1.6	-0.4	-1.6	-1.5	-1.9	1.4
Neck or shoulder pain in last month	0.4	0.6	2.2	-0.5	0.2	1.5	1.3	0.5	0.5	-0.5	0.7	0.4	0.8	-0.6
Medication: Blood pressure	0.2	0.3	0.8	-0.8	0.8	0.9	0.5	0.3	0.6	-0.1	0.2	0.7	0.2	0.5
Angina (self-reported)	0.4	0.6	3.0	0.3	-0.9	0.0	-0.4	-1.2	0.2	-1.7	-0.6	-0.3	-0.7	-0.3
Migraine (self-reported)	0.4	0.5	3.6	-0.6	1.9	0.2	0.1	0.4	0.2	-0.4	0.7	0.4	0.5	0.4
Medication: Ibuprofen	3.2	3.8	7.2	-1.9	1.7	1.6	1.0	2.1	2.4	0.0	2.3	2.0	2.2	-2.7
Medication: Allopurinol	0.5	0.6	1.0	0.8	-0.7	-0.6	-1.0	-1.0	-0.5	-0.6	-0.9	-1.0	-0.8	0.5
Medication: Omeprazole	1.5	1.8	3.4	-1.1	0.6	0.8	1.1	1.7	1.8	1.0	1.5	1.3	1.4	-1.7
Medication: Seretide 50 evohaler	2.4	2.7	6.2	1.3	-2.5	-1.1	-2.0	-1.6	-1.8	-2.1	-1.5	-1.3	-1.6	0.5
Mean time to correctly identify matches	1.7	3.2	8.7	2.8	-3.0	-1.1	-2.1	-1.3	-1.4	-0.0	-1.6	-1.3	-1.5	1.7
Heart disease (mother)	0.6	0.7	2.6	-0.4	-0.5	1.6	0.9	0.7	1.0	0.6	0.7	0.4	0.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.7	-0.5	0.2	0.2	-0.4	0.1	-0.8	-0.6	-0.4	-0.6	0.3
Whole body fat mass	1.8	7.5	10.8	-3.2	2.5	3.3	2.7	2.8	2.7	2.4	3.0	2.8	3.2	-0.9
Leg fat mass (right)	2.7	10.4	15.4	-3.7	3.0	3.9	3.2	3.2	3.1	3.1	3.5	3.1	3.7	-0.7
Arm predicted mass (right)	1.7	8.5	13.3	-3.5	3.6	2.7	2.8	3.0	1.9	2.5	3.3	2.5	3.3	-2.4
Pulse rate, automated reading	4.7	15.2	23.1	-4.8	4.6	4.5	4.6	4.0	2.8	2.1	4.1	4.2	4.0	-1.9
Alcohol intake frequency.	0.1	0.1	0.9	0.3	0.1	0.6	-0.1	-0.0	0.0	-0.2	0.3	-0.3	0.3	0.9
Comparative height size at age 10	0.5	2.7	6.2	-0.8	1.2	0.9	1.2	2.2	1.8	0.9	2.3	1.0	1.9	-2.5
Number of full sisters	1.7	2.1	3.1	1.8	-1.2	-1.4	-1.6	-1.7	-0.5	-0.8	-1.6	-1.6	-1.5	1.7
Suffer from ‘nerves’	1.7	2.6	6.7	-0.8	0.1	1.6	1.5	1.8	1.9	0.6	1.9	1.8	1.8	-2.6
Overall health rating	1.6	3.5	8.0	-1.7	1.3	2.8	2.2	2.0	1.3	1.3	2.2	1.6	2.4	-0.4
Chest pain or discomfort	1.8	2.6	8.3	2.1	-2.9	-0.8	-1.6	-1.6	-0.5	-2.0	-1.3	-1.5	-1.3	0.6
Had major operations	0.5	0.6	2.5	-0.4	1.6	0.9	0.5	0.3	-0.0	0.6	0.9	0.5	0.9	-0.3
Age at last live birth	0.7	1.0	3.4	0.9	-0.8	-1.8	-1.2	-0.8	-0.9	-1.3	-0.6	-0.7	-0.7	-0.6
Family relationship satisfaction	0.2	0.3	1.4	0.6	-0.0	-1.2	-0.5	-0.2	0.5	-0.9	-0.1	-0.3	-0.1	0.2
Leg pain on walking	3.1	3.9	6.3	-1.5	1.9	1.8	2.3	2.1	2.2	2.0	2.3	2.0	2.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.6	0.3	-0.1	-0.1	-0.4	-0.9	-0.3	1.2	-0.4	-0.5	-0.3	1.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	-0.8	0.1	-0.0	0.1	0.6	-0.1	0.4	0.1	0.3	0.1	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.4	0.9	-1.1	-0.7	-0.4	-0.8	-1.6	0.4	-0.8	-0.5	-1.0	0.7
Medication: Aspirin	0.4	0.5	1.0	-0.7	0.6	0.7	0.4	0.4	0.8	-1.0	0.6	0.6	0.5	-1.0
Supplements: Vitamin C	2.8	3.3	6.0	-2.5	1.4	2.0	2.2	1.6	0.8	1.2	1.8	2.3	1.8	-1.6
Knee pain experienced in last month	8.9	13.9	22.1	-3.6	3.0	4.7	4.4	4.0	2.9	3.5	3.9	4.0	4.3	-1.6
Hypertension (Self-reported)	0.2	0.5	2.3	-0.3	0.8	0.6	0.4	0.0	0.5	1.5	-0.0	0.2	0.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.0	-0.8	0.2	0.1	0.2	-0.2	0.3	-0.0	-0.2	0.2	-0.3
Illnesses of father: Heart disease	0.7	1.0	2.0	0.6	-0.5	-1.1	-1.0	-1.2	-1.4	-1.3	-1.0	-0.7	-1.2	-0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.8	-0.7	-0.9	-0.9	-0.6	-1.1	0.7	-0.6	-0.9	-0.5	0.9
Smoking status: Previous	0.1	0.2	0.6	-0.5	0.1	0.8	0.0	0.1	-0.5	0.2	0.2	0.6	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.3	0.2	-0.5	0.3	0.5	0.6	0.6	0.8	0.1	0.7	-1.2
Whole body fat-free mass	1.3	7.3	10.4	-3.2	3.2	2.4	2.6	2.8	1.9	2.1	3.1	2.6	3.2	-2.4
Leg fat-free mass (right)	1.0	5.5	7.6	-2.7	2.8	2.1	2.2	2.4	2.1	1.5	2.7	2.4	2.7	-2.0
Arm fat percentage (left)	1.1	4.5	6.7	-2.4	1.8	2.6	2.1	2.0	2.5	2.3	2.1	2.1	2.3	0.2
Average weekly red wine intake	0.1	0.2	1.0	-0.1	0.9	-0.2	0.4	-0.2	1.0	0.2	0.1	-0.1	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	3.8	0.2	0.0	0.6	-0.1	0.2	-0.3	2.0	0.4	0.1	0.6	0.4
Mood swings	1.0	1.8	3.3	-0.9	0.2	1.2	1.8	1.8	1.5	0.6	1.4	1.4	1.3	-1.6
Loneliness, isolation	0.6	0.8	2.3	-0.6	0.3	1.1	1.2	0.8	1.5	0.3	0.6	1.1	0.7	-0.9
Long-standing illness, disability or infirmity	1.1	1.7	4.4	1.6	-2.1	-0.1	-0.9	-1.1	-1.1	0.1	-1.4	-1.0	-1.0	2.0
Ever had bowel cancer screening	0.7	0.9	2.1	1.0	-0.5	-1.4	-1.1	-0.7	-1.1	-1.2	-0.8	-0.4	-0.9	0.4
Diabetes diagnosed by doctor	2.2	3.5	6.0	1.9	-2.2	-1.6	-2.5	-2.0	-1.7	-1.8	-2.0	-1.6	-2.0	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.8	0.9	0.1	-1.2	-1.1	-1.5	-1.0	-0.3	-0.9	-0.5	-1.0	1.9
Friendships satisfaction	0.2	0.2	0.6	-0.2	0.8	-0.4	0.1	0.4	0.6	-0.4	0.4	0.6	0.4	-0.3
Qualifications: nursing, teaching	2.7	4.2	7.2	1.7	-0.7	-1.9	-2.0	-2.7	-2.2	-1.9	-2.3	-2.2	-2.3	2.2
Commuting to job workplace: Walk	0.7	0.7	1.5	1.0	-1.2	-1.1	-0.5	-0.8	-0.6	-0.6	-1.0	-0.7	-1.0	-0.7
Eye problems/disorders: Cataract	0.7	0.8	2.3	1.0	-1.5	-0.9	-1.1	-1.0	-0.7	-0.9	-0.7	-0.6	-0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	-1.6	0.1	1.9	1.8	1.7	0.9	0.3	1.6	1.4	1.5	-2.0
Medication for cholesterol	0.2	0.3	1.0	0.2	0.3	0.6	0.4	0.4	0.9	-0.0	0.4	0.5	0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	0.1	-0.4	0.3	0.0	0.3	0.3	0.2	-0.2	-0.7	-0.2	-0.8
Back pain experienced in last month	1.4	2.0	3.2	-1.4	0.8	1.4	0.8	1.8	1.5	0.7	1.8	1.8	1.7	-1.3
Mineral and other dietary supplements	6.6	8.8	17.1	3.3	-1.9	-2.7	-2.5	-3.3	-2.9	-1.4	-3.3	-3.1	-3.3	4.1
Breast cancer (self-reported)	0.4	0.4	0.9	0.7	-0.8	0.1	0.0	-0.6	-0.9	-0.7	-0.6	-0.9	-0.3	0.8
Asthma (self-reported)	1.3	2.6	4.7	1.6	-2.2	-1.4	-1.4	-1.7	-2.0	-1.5	-1.6	-1.3	-1.7	0.7
Osteoporosis (self-reported)	0.7	0.8	2.0	0.7	-0.6	-0.9	-1.1	-1.2	-0.9	-1.4	-0.6	-0.2	-0.9	-0.7
Osteoarthritis (self-reported)	1.2	1.5	3.1	-1.1	-0.0	1.8	1.4	1.2	1.5	0.9	1.4	1.3	1.4	-0.7
Medication: Aspirin	0.4	0.5	1.7	-0.5	0.9	0.7	0.4	0.1	0.7	-1.3	0.6	0.5	0.4	-0.8
Medication: Gliclazide	0.3	0.3	1.1	-0.1	-0.7	0.0	0.2	0.4	-1.1	0.4	0.5	0.3	0.5	-1.0
Illnesses of father: None of the above (group 1)	0.2	0.3	1.7	0.3	-0.3	0.1	-0.1	-0.1	0.0	0.6	-0.4	-0.4	-0.3	1.3
Smoking status: Current	0.9	1.4	2.5	1.4	-0.5	-0.9	-1.3	-1.2	-1.0	-0.8	-1.1	-1.4	-1.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.0	-0.2	-0.2	-0.9	-0.5	-0.0	1.0	-1.7	-0.2	-0.2	-0.4	-2.0
Whole body water mass	1.3	7.2	9.9	-3.1	3.1	2.5	2.6	2.7	2.0	2.0	3.1	2.6	3.1	-2.5
Leg predicted mass (right)	1.0	5.1	7.2	-2.6	2.7	2.0	2.1	2.2	2.0	1.5	2.5	2.3	2.6	-1.9
Arm fat mass (left)	2.0	8.1	11.5	-3.4	2.7	3.2	2.9	2.8	2.7	2.7	3.1	2.8	3.3	-0.9
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.2	0.1	0.3	-0.1	0.1	0.0	0.1	0.2	0.5	0.1	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.2	-0.7	-0.5	-1.0	-0.9	-0.3	-0.6	-0.7	-0.5	-0.7	0.3
Miserableness	0.8	1.4	3.3	1.8	-1.5	-1.0	-1.3	-0.9	-0.0	-1.1	-1.1	-1.7	-1.0	0.8
Guilty feelings	1.3	2.0	8.2	0.1	0.6	0.7	1.2	1.6	2.0	2.9	1.4	0.4	1.7	-0.4
Wears glasses or contact lenses	1.6	1.9	3.7	1.7	-1.1	-1.9	-1.8	-1.2	-0.9	-1.1	-1.4	-1.2	-1.5	0.1
Ever taken oral contraceptive pill	1.1	1.2	2.8	0.7	-0.1	-1.2	-1.3	-1.5	0.1	-1.5	-1.0	-0.6	-1.1	1.7
Hearing aid user	0.6	0.7	3.2	0.6	-0.6	-0.3	-0.9	-1.1	-0.0	-1.8	-0.4	-1.0	-0.5	0.2
Mother’s age at death	0.2	0.3	1.2	-0.1	-0.7	0.2	0.1	0.5	1.1	0.5	0.5	0.2	0.6	-0.4
Financial situation satisfaction	0.2	0.3	0.9	-1.0	0.5	-0.1	0.6	0.5	-0.0	-0.2	0.5	0.8	0.8	-0.2
Tinnitus: Yes, now most or all of the time	2.8	3.3	6.6	1.9	-0.9	-1.4	-1.8	-2.2	-2.2	-0.6	-2.1	-1.5	-1.8	2.6
Commuting to job workplace: Public transport	1.5	1.7	4.4	1.0	-2.1	-0.8	-1.1	-1.3	-1.7	-1.7	-1.5	-0.7	-1.3	0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	0.5	-0.0	-0.5	0.2	0.2	0.1	-0.1	-0.4	-0.0	-0.4	-0.8
Medication: Blood pressure	0.2	0.3	1.1	-0.1	-0.5	-1.0	-0.5	-0.3	-1.0	-0.2	-0.6	-0.7	-0.5	0.2
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.6	-0.9	1.1	1.4	1.1	1.5	1.2	0.6	1.5	1.3	1.9	-0.7
Supplements: Fish oil (including cod liver oil)	7.1	9.2	15.8	-3.4	1.7	3.0	2.7	3.3	3.0	2.3	3.1	3.2	3.1	-4.0
High cholesterol (Self-reported)	1.0	1.7	4.3	-1.5	2.1	0.6	1.0	1.3	1.3	0.4	1.6	1.6	1.5	-0.3
Medication: Bendroflumethiazide	0.8	1.2	3.7	-1.8	0.8	0.7	0.8	1.3	0.6	0.2	0.9	0.9	0.9	-1.9
Medication: Paracetamol	1.7	2.7	5.4	-1.6	1.3	2.0	1.2	1.9	1.4	0.9	2.0	1.8	2.3	-0.8
Medication: Lisinopril	0.3	0.4	2.1	0.1	-0.1	-0.6	-0.5	-0.6	-1.1	-1.4	-0.4	0.1	-0.5	0.2
Medication: Atorvastatin	0.2	0.2	1.3	-0.2	0.4	-0.4	-0.1	-0.3	0.3	-0.7	-0.2	0.1	-0.1	1.1
Illnesses of father: High blood pressure	0.6	0.7	2.3	-0.7	1.5	0.2	0.7	0.6	0.7	-1.1	0.6	0.3	0.5	-1.4
Alcohol drinker status: Never	2.3	2.8	8.5	2.1	-1.0	-1.3	-1.1	-1.4	-1.4	-0.1	-1.8	-2.0	-1.5	2.9
Ever smoked	0.6	1.1	4.4	-0.6	0.3	2.1	1.1	0.7	1.5	0.1	1.1	0.8	1.1	-0.5
Basal metabolic rate	1.6	8.7	12.0	-3.5	3.4	2.8	2.8	3.0	2.3	2.3	3.4	2.8	3.5	-2.4
Leg fat percentage (left)	2.6	9.4	17.7	-3.7	2.6	4.2	3.1	2.9	2.7	3.1	3.1	2.9	3.4	0.1
Arm fat-free mass (left)	2.0	10.2	14.7	-3.8	3.8	3.2	3.1	3.2	2.2	2.6	3.6	2.9	3.7	-2.5
Number of operations (self-reported)	0.3	0.5	2.8	0.4	0.8	0.6	0.1	-0.7	-0.7	-0.1	-0.1	0.3	-0.0	1.7
Average weekly beer plus cider intake	1.0	1.4	3.3	-1.1	0.0	1.8	1.4	1.4	1.1	1.7	1.0	0.4	1.3	-0.0
Irritability	0.3	0.5	2.1	0.7	-1.4	0.7	0.1	0.1	0.9	1.0	-0.1	0.0	0.2	0.5
Risk taking	0.9	1.3	2.1	-1.1	1.4	1.3	0.9	1.0	0.9	1.2	1.3	1.1	1.3	0.2
Ever had prostate specific antigen (PSA) test	8.9	10.3	15.9	-3.1	2.4	3.4	2.8	3.4	4.0	2.9	3.6	3.1	3.5	-2.8
Fractured/broken bones in last 5 years	1.8	2.3	4.8	-1.6	2.2	1.7	1.9	1.6	1.1	0.3	1.5	1.4	1.4	-1.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.1	-0.2	-0.1	0.2	0.4	-0.1	0.4	0.2	0.4	0.4	-0.3
Diastolic blood pressure, automated reading	1.9	5.7	11.2	-3.4	3.0	2.0	2.5	2.5	1.4	2.1	2.1	2.6	2.3	-1.8
Ever depressed for a whole week	0.3	0.4	2.4	0.2	0.1	-0.6	-0.7	-0.6	-1.6	-0.3	-0.4	0.0	-0.2	0.8
Unable to work because of sickness or disability	0.3	0.4	1.3	0.7	-0.7	-0.2	-0.2	-0.7	-0.5	-0.4	-0.7	-0.6	-0.6	1.1
Commuting to job workplace: Cycle	0.6	0.7	2.5	0.5	-0.3	-1.0	-0.8	-1.0	-0.6	-1.6	-0.7	-0.9	-0.8	0.1
Myopia	0.4	0.5	3.3	-0.2	0.6	0.1	-0.5	0.2	0.6	1.8	-0.0	0.6	0.1	0.9
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.9	0.8	-1.0	-0.7	-0.4	-0.1	-0.7	-0.8	-0.4	-0.7	-0.5	-0.9
Cholesterol lowering medication	0.4	0.6	1.9	-1.0	0.8	0.2	0.4	0.7	0.4	1.4	0.8	0.7	0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	4.9	-1.3	1.3	1.2	1.7	2.2	2.1	1.9	1.9	1.5	2.1	-1.1
Pain experienced in last month	5.0	8.3	15.6	2.3	-2.4	-3.9	-3.0	-3.0	-2.6	-1.7	-3.6	-3.0	-3.6	1.5
Supplements: Calcium	0.6	0.7	1.4	-1.1	0.9	0.8	0.8	0.6	0.8	-0.6	0.9	0.7	0.7	-1.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.5	0.3	0.0	0.5	0.7	0.7	0.5	0.7	0.7	0.6	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.9	-0.3	-0.4	-0.1	-0.8	0.6	-0.2	-0.6	-0.9	-0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.5	0.9	0.0	-1.1	-1.2	-1.8	-0.9	-1.9	-1.3	-0.7	-1.3	1.4
Heart disease (siblings)	0.1	0.2	1.0	-0.3	-0.3	0.5	0.2	0.2	-0.0	1.0	0.4	-0.1	0.3	0.2
Alcohol drinker status: Previous	0.3	0.3	1.4	-0.5	1.2	0.3	0.2	0.0	-0.3	-1.0	0.6	0.3	0.5	-0.2
Pack years of smoking	4.1	6.0	8.5	2.5	-2.2	-2.5	-2.9	-2.8	-1.8	-1.8	-2.8	-2.3	-2.8	2.3
Impedance of whole body	0.8	4.1	8.2	2.9	-2.7	-2.5	-2.4	-1.5	-0.7	-2.1	-1.8	-1.9	-2.1	0.1
Leg fat mass (left)	2.8	11.0	16.9	-3.9	3.1	4.1	3.3	3.3	3.1	3.1	3.6	3.2	3.8	-0.8
Arm predicted mass (left)	2.1	10.8	15.8	-4.0	3.8	3.2	3.2	3.3	2.2	2.9	3.7	3.0	3.8	-2.5