Hub : Genes

ATG14

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0280 0.0120 6.7e-04 0.019 0.023 0.016 0.022 0.016 2.1e-03 7.6e-04 3.6e-03 9.5e-04 4.4e-03
2 GTEx Adipose Subcutaneous 0.0810 0.0290 2.5e-05 0.014 NA 0.057 NA 0.038 2.1e-02 NA 2.0e-05 NA 4.3e-04
3 GTEx Artery Tibial 0.0507 0.0213 8.6e-04 0.057 NA 0.038 NA 0.035 3.0e-05 NA 5.3e-04 NA 8.3e-04
4 GTEx Cells Transformed fibroblasts 0.0970 0.0380 7.1e-05 0.013 NA 0.020 NA 0.023 3.3e-02 NA 1.1e-02 NA 7.3e-03
5 GTEx Esophagus Mucosa 0.1290 0.0350 1.7e-09 0.131 NA 0.159 NA 0.172 4.9e-09 NA 8.8e-11 NA 1.2e-11
6 GTEx Muscle Skeletal 0.0797 0.0306 7.5e-05 0.027 NA 0.029 NA 0.012 1.1e-03 NA 6.5e-04 NA 2.1e-02
7 GTEx Nerve Tibial 0.0571 0.0271 6.3e-03 0.016 NA -0.003 NA -0.002 2.3e-02 NA 6.1e-01 NA 4.7e-01
8 GTEx Skin Not Sun Exposed Suprapubic 0.1260 0.0470 2.3e-04 0.077 NA 0.047 NA 0.065 4.8e-05 NA 1.4e-03 NA 1.8e-04
9 GTEx Skin Sun Exposed Lower leg 0.1010 0.0300 4.5e-09 0.104 NA 0.144 NA 0.154 5.7e-09 NA 6.2e-12 NA 1.0e-12
10 GTEx Testis 0.1240 0.0450 5.9e-05 0.161 NA 0.123 NA 0.150 1.2e-07 NA 4.4e-06 NA 3.4e-07
11 METSIM Adipose 0.0521 0.0200 1.9e-05 0.062 0.028 0.064 0.035 0.065 1.4e-09 3.6e-05 6.3e-10 4.3e-06 4.5e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.2 0.3 1.4 -0.3 0.1 -0.3 0.2 0.6 -0.2 0.8 0.5 0.8 0.3 -1.2
Bipolar Disorder or Schizophrenia 0.0 0.1 0.3 0.5 -0.0 -0.5 -0.2 -0.3 -0.1 -0.3 0.1 0.0 -0.2 0.0
Depressed Affect (Nagel 2018) 0.1 0.2 1.0 0.6 -1.0 -0.1 0.0 0.1 0.4 -0.1 -0.2 0.2 -0.2 -0.5
Depression (Nagel 2018) 0.5 0.8 1.6 1.3 -1.2 -0.9 -0.7 -0.6 -0.3 -0.8 -0.8 -1.2 -0.8 0.6
Intelligence (Savage-Jansen 2018) 1.8 5.7 9.3 2.9 -2.6 -1.4 -2.7 -2.8 -1.4 -2.1 -2.3 -3.1 -2.8 1.3
Neuroticism (Nagel 2018) 0.3 0.8 1.4 0.2 -0.5 0.8 1.1 1.1 1.1 0.9 0.8 0.5 0.9 -1.2
Schizophrenia (2018) 0.2 0.4 1.1 0.9 -0.1 -0.4 -0.4 -0.9 0.1 -1.0 -0.2 -0.6 -0.6 1.0
Schizophrenia vs Biploar Disorder 0.1 0.2 0.7 0.2 0.4 0.1 0.1 0.0 0.8 -0.8 0.2 -0.5 0.3 0.1
Worry (Nagel 2018) 1.7 3.6 6.4 -1.0 0.8 1.7 1.8 2.4 2.2 1.5 2.2 1.5 2.2 -2.5
Alzheimer’s Disease (in mother) 0.3 0.4 1.8 -0.2 -0.5 0.8 0.2 0.8 0.5 1.3 0.4 -0.2 0.6 -0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.6 -0.8 -0.4 -0.4 -0.0 -0.5 0.8 -0.1 -0.3 0.0 -0.3
Alzheimer’s Disease (including proxy) 0.3 0.5 2.6 0.0 -1.0 0.1 -0.1 0.7 0.1 1.6 0.3 -0.2 0.6 -0.7
Crohns Disease (2017) 0.9 1.9 4.7 -1.3 1.7 1.5 1.8 1.1 -0.1 2.2 1.1 1.3 1.3 0.4
Irritable Bowel Disease (IBD) 0.8 1.8 4.4 -1.4 1.4 1.3 1.8 1.3 -0.2 2.1 1.1 1.3 1.4 0.1
Ulcerative Colitis (UC) 0.2 0.4 1.1 -0.7 0.5 0.4 0.8 0.7 -0.0 1.1 0.5 0.8 0.8 -0.4
Major Depression (MDD) 0.2 0.3 0.9 0.2 -0.8 0.5 0.5 0.1 0.1 0.2 0.2 -0.6 0.6 0.9
Reaction Time 1.0 2.0 5.4 2.3 -2.1 -1.1 -1.8 -0.9 -0.3 0.4 -1.2 -1.2 -1.2 1.3
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.6 1.5 -1.2 -0.4 -1.4 -1.6 -1.2 -0.4 -1.2 -1.5 -1.3 1.6
Breast Cancer 0.0 0.1 0.2 -0.0 -0.4 0.3 -0.3 0.3 -0.0 -0.4 -0.4 -0.2 -0.2 0.4
Ovarian Cancer 0.3 0.4 2.1 -0.2 0.1 0.8 0.6 0.0 -0.1 1.5 0.2 0.4 0.2 1.1
Prostate Cancer 1.0 1.3 2.4 -0.9 1.5 1.5 1.3 1.1 1.3 0.3 1.1 1.4 1.1 -0.3
Age at First Birth 1.5 2.2 3.8 1.6 -1.7 -1.9 -1.9 -1.4 -0.7 -0.5 -1.6 -1.6 -1.8 0.0
Bipolar Disorder (2011) 0.1 0.1 0.3 0.5 -0.1 -0.2 -0.3 -0.5 -0.0 -0.4 -0.1 0.1 0.1 -0.3
Body Mass Index (BMI) (2010) 0.9 1.2 2.3 -1.1 1.5 0.8 0.8 1.2 1.2 0.5 1.3 1.0 1.1 -1.1
Coronary Artery Disease (CAD) 0.4 0.4 2.9 -0.2 0.8 -0.6 -0.5 -0.5 -0.1 -1.7 -0.4 -0.2 -0.4 0.1
Crohns Disease (2012) 0.1 0.2 0.7 -0.5 0.6 0.5 0.8 0.1 -0.2 0.7 0.2 -0.0 0.1 0.5
Mean Putamen Volume 0.9 1.1 3.5 -1.9 1.3 1.3 0.7 -0.1 -1.2 -1.0 0.8 0.7 0.5 -0.5
Fasting Glucose 0.3 0.3 1.0 0.6 0.0 -1.0 0.3 -0.7 -0.4 0.2 -0.7 -0.6 -0.7 -0.2
HbA1C 0.4 0.4 1.5 0.7 0.0 -0.1 -1.0 -0.1 0.3 1.2 -0.2 0.3 -0.2 1.1
HDL Cholesterol 0.2 0.3 0.6 -0.4 -0.3 0.7 0.4 0.5 0.2 0.6 0.4 0.5 0.5 -0.8
LDL Cholesterol 0.2 0.3 0.5 0.4 -0.7 0.1 -0.7 -0.6 -0.4 -0.6 -0.6 -0.2 -0.6 -0.0
Lupus 0.4 0.7 2.4 0.4 -0.4 -0.1 -0.1 -1.1 -0.6 -1.2 -0.9 0.2 -0.8 1.6
Neuroticism (2016) 1.2 1.8 5.8 -0.3 -0.1 1.3 0.8 1.5 2.4 0.6 1.2 1.5 1.2 -1.9
Primary Biliary Cirrhosis 1.5 2.1 6.4 -0.8 0.5 0.8 1.5 1.6 1.6 2.5 1.5 1.0 1.5 -1.4
Rheumatoid Arthritis 0.5 0.7 4.5 -0.2 -0.5 -0.4 0.2 0.9 0.9 -0.5 0.4 1.0 0.1 -2.1
Schizophrenia (2014) 0.1 0.2 0.5 0.6 0.1 -0.7 -0.5 -0.4 0.5 -0.7 0.1 -0.4 -0.3 -0.1
Triglycerides 0.2 0.3 0.8 0.4 -0.6 -0.8 -0.5 -0.4 -0.6 -0.5 -0.3 -0.9 -0.5 -0.2
Type 2 Diabetes (T2D) (2012) 0.3 0.3 2.0 -0.2 -0.1 0.4 -0.0 0.4 1.4 0.1 0.7 0.5 0.3 -0.8
Ulcerative Colitis 0.2 0.4 1.0 -0.6 0.2 -0.0 0.5 1.0 0.1 0.3 0.6 0.4 0.8 -1.0
Blood Eosinophil Count 9.5 73.2 95.3 9.5 -8.0 -9.6 -9.4 -9.3 -7.1 -5.6 -9.8 -8.6 -9.7 6.2
Blood Platelet Count 4.5 51.6 78.3 8.4 -7.4 -8.8 -8.3 -7.2 -5.0 -2.9 -8.0 -7.9 -8.1 4.3
Blood Red Count 1.6 15.2 20.6 4.1 -4.5 -4.5 -4.3 -3.9 -3.8 -1.6 -4.0 -4.5 -4.2 2.1
Blood White Count 3.5 26.1 58.6 5.5 -3.9 -3.4 -4.6 -5.9 -4.1 -2.1 -5.6 -6.0 -5.2 7.7
Heel T-Score 0.3 2.1 4.2 1.5 -0.9 -0.9 -1.4 -2.0 -1.6 0.3 -1.6 -1.5 -1.6 1.7
BMI 2.4 13.7 18.2 -4.2 3.9 4.3 4.2 3.7 2.6 4.0 4.0 3.4 4.2 -0.7
Height 0.2 4.2 31.9 0.6 -1.1 -2.0 -1.1 1.2 -0.2 -1.8 1.2 0.9 0.6 -5.7
Waist Hip Ratio (WHR) 0.1 0.3 0.7 -0.2 0.8 0.8 0.3 0.5 -0.1 -0.6 0.4 0.4 0.6 0.8
Systolic Blood Pressure 0.9 4.6 8.7 1.2 -1.8 -2.9 -1.9 -2.1 -2.2 -0.2 -2.9 -2.5 -2.7 1.7
Smoking Status 0.2 0.6 2.8 0.4 -0.0 0.3 -0.5 -0.7 -1.2 -0.3 -0.8 -0.4 -0.5 1.7
Allergy or Eczema 0.7 1.7 2.5 1.5 -1.6 -1.4 -1.3 -1.2 -1.6 -1.4 -1.3 -1.3 -1.2 -0.2
Cardiovascular Disease 0.3 0.9 2.8 -1.3 0.9 0.3 0.6 1.0 1.1 1.7 0.8 0.9 0.7 0.2
Hypothyroidism (self reported) 3.4 7.8 10.6 2.4 -1.9 -3.2 -3.0 -3.2 -2.6 -3.0 -3.2 -2.4 -3.1 2.1
Respiratory disease 0.1 0.3 1.8 0.3 -1.3 -0.2 -0.3 -0.1 -0.7 -0.7 -0.2 0.0 -0.1 -0.5
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.2 0.9 -1.4 -0.5 -1.3 -1.1 -1.5 -1.0 -1.1 -0.9 -1.0 0.6
Lung FEV1/FVC ratio 1.0 5.2 15.3 2.5 -2.6 -3.9 -2.6 -1.7 -1.3 -1.6 -1.9 -2.2 -2.4 -1.1
Lung FVC 0.1 0.6 3.3 -0.5 0.8 0.6 0.2 -0.3 0.5 -0.7 -0.2 0.9 -0.1 1.8
Neuroticism 0.5 1.2 4.7 0.3 -1.2 0.4 0.7 1.2 1.6 0.6 0.9 0.5 0.8 -2.2
Chronotype (morning person) 1.8 4.1 9.1 2.7 -1.7 -1.8 -1.8 -2.4 -1.5 -1.1 -2.0 -3.0 -1.8 1.7
Hair Pigment 0.0 1.2 2.9 -1.6 1.7 1.4 0.8 0.5 1.3 -0.9 0.8 0.9 0.6 1.1
Tanning 0.4 5.0 11.0 -3.2 2.1 3.3 3.0 2.0 0.0 2.0 1.7 2.2 2.1 -0.8
Hand grip strength (left) 0.2 0.6 2.0 -0.2 1.0 -1.4 -0.1 -0.8 -1.0 -0.1 -0.5 -0.5 -0.6 1.1
Number of treatments/medications taken 0.8 1.5 2.3 -1.4 1.2 1.4 0.9 1.5 0.8 -0.0 1.5 1.3 1.4 -1.1
Average weekly spirits intake 2.5 3.1 5.3 -1.9 1.3 2.3 1.8 2.2 1.2 2.0 1.7 1.8 1.9 -0.0
Sensitivity / hurt feelings 0.5 0.8 2.1 -0.0 -0.3 1.4 1.3 1.2 1.0 0.1 0.8 -0.1 0.9 -0.9
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 0.8 0.5 -0.6 -0.1 -0.2 0.5 0.4 -0.1 -0.7 -0.0 1.2
Hearing difficulty/problems: Yes 0.6 0.9 2.7 0.6 -1.4 -0.4 -1.3 -0.8 -1.6 -0.4 -1.0 0.0 -0.9 0.7
Relative age of first facial hair 0.8 1.7 4.4 1.1 -1.2 -1.4 -1.0 -1.3 -2.1 -0.7 -1.5 -1.2 -1.5 0.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.7 0.0 -0.2 0.3 -0.3 -0.7 0.5 -0.6 -0.3 0.0 -0.2 1.3
Ever used hormone-replacement therapy (HRT) 1.6 2.1 3.8 1.4 -0.7 -1.4 -1.1 -1.5 -1.8 -1.5 -1.6 -1.1 -1.4 1.9
Ever had hysterectomy (womb removed) 0.2 0.2 0.9 -0.8 0.3 0.1 0.1 0.3 -0.9 0.2 0.2 0.4 0.3 0.1
Systolic blood pressure, automated reading 0.1 0.3 0.9 -0.5 -0.0 -0.9 0.1 -0.1 -0.8 0.1 -0.8 -0.4 -0.6 -0.5
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.5 -0.9 0.9 0.4 0.9 1.1 1.1 0.1 1.2 0.4 1.0 -1.1
Angina 0.5 0.6 3.0 0.3 -1.1 -0.2 -0.4 -1.2 -0.0 -1.7 -0.6 -0.3 -0.7 -0.5
Medication for hormone replacement therapy 1.3 1.4 5.3 0.9 -0.4 -0.5 -0.6 -1.7 -1.3 -1.2 -0.8 -1.3 -0.9 2.3
Vitamin and mineral supplements 11.8 16.0 21.8 4.2 -3.2 -4.7 -4.4 -4.4 -3.6 -2.4 -4.6 -3.8 -4.4 3.7
Supplements: Zinc 0.0 0.0 0.2 -0.3 -0.2 -0.2 -0.4 -0.2 0.3 0.2 -0.1 -0.0 -0.1 0.2
Medication: Co-codamol 0.7 0.8 1.8 -0.6 0.1 1.3 0.7 1.0 1.1 0.7 1.2 0.8 1.3 -0.1
Medication: Metformin 1.0 1.4 2.1 0.9 -1.4 -0.4 -1.4 -1.4 -1.3 -1.2 -1.2 -0.8 -1.1 1.3
Diabetes (father) 0.1 0.1 0.3 0.2 -0.0 -0.2 -0.3 0.4 -0.4 -0.5 0.4 -0.2 0.4 -0.3
Diabetes (mother) 0.7 0.8 2.9 -1.0 0.5 1.7 0.6 0.7 0.8 -0.1 0.9 1.2 0.9 -0.8
Severe depression (siblings) 1.2 1.3 3.2 1.4 -0.4 -1.3 -1.2 -1.1 -0.7 -1.8 -1.0 -1.2 -1.1 0.6
Pack years adult smoking proportion 5.3 8.0 10.9 2.9 -2.4 -3.0 -3.3 -3.2 -2.0 -2.2 -3.2 -2.8 -3.2 2.6
Impedance of leg (right) 0.2 1.1 2.9 1.4 -1.7 -1.1 -1.4 -0.7 -0.6 -0.6 -0.9 -1.1 -1.0 0.1
Leg fat-free mass (left) 1.1 5.7 7.6 -2.7 2.7 2.3 2.3 2.4 2.2 1.7 2.7 2.4 2.8 -1.8
Trunk fat percentage 1.1 4.6 6.6 -2.2 1.8 2.6 2.0 2.2 2.4 2.0 2.3 2.4 2.4 -0.3
Hand grip strength (right) 0.2 0.5 2.5 -0.2 0.4 -1.6 -0.4 -0.7 -0.2 -0.9 -0.7 -0.5 -1.0 -0.1
Townsend deprivation index at recruitment 0.6 0.8 1.7 -0.4 0.6 1.2 0.9 0.8 0.8 0.9 1.0 1.3 1.0 0.5
Current tobacco smoking 1.2 2.0 3.2 1.5 -0.6 -1.2 -1.5 -1.5 -1.5 -1.2 -1.4 -1.6 -1.5 1.8
Average weekly fortified wine intake 0.6 0.7 1.6 1.3 -1.2 -0.3 -0.7 -0.6 -0.3 0.9 -0.5 -1.2 -0.5 0.7
Maternal smoking around birth 0.8 1.1 2.1 0.8 -0.3 -1.5 -1.3 -0.8 -1.4 -0.7 -1.3 -0.7 -1.1 1.3
Fed-up feelings 1.0 1.8 2.7 -1.1 0.5 1.2 1.1 1.5 1.6 1.5 1.5 1.6 1.6 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.8 0.6 -0.5 -0.5 -0.5 -0.4 -0.7 -0.5 -0.5 -0.8 -0.4 0.9
Relative age voice broke 1.3 2.0 3.4 1.6 -1.5 -1.6 -1.1 -1.2 -1.8 -0.0 -1.8 -1.4 -1.7 0.7
Taking other prescription medications 0.0 0.0 0.2 0.1 -0.1 -0.1 -0.1 -0.0 -0.5 -0.3 0.1 0.2 0.1 0.1
Age when periods started (menarche) 1.0 2.4 6.9 2.6 -2.0 -1.4 -1.6 -1.3 0.1 -0.5 -1.7 -1.5 -1.7 0.9
Bilateral oophorectomy (both ovaries removed) 2.5 2.9 6.4 1.6 -1.8 -1.1 -1.2 -2.0 -2.5 -1.5 -1.8 -1.7 -1.6 1.4
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.1 1.9 -0.9 -1.4 -1.5 -1.8 -0.9 -0.0 -2.0 -2.3 -1.9 2.2
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 5.1 1.7 -1.5 -1.5 -2.2 -1.9 -0.7 -2.1 -1.6 -1.4 -1.9 0.7
Qualifications: CSEs or equivalent 0.8 1.0 1.6 -0.9 1.1 1.1 1.2 1.2 0.9 0.0 1.2 0.7 1.1 -1.1
Serious illness, injury or assault to yourself 0.5 0.6 1.5 -1.1 0.7 1.2 0.9 0.7 0.6 -0.0 0.4 0.8 0.8 0.4
High blood pressure 0.3 0.7 1.9 -0.8 1.2 0.9 0.7 0.4 1.0 1.4 0.5 0.7 0.6 1.0
Hayfever, allergic rhinitis or eczema 1.8 3.8 6.0 1.9 -1.5 -2.4 -1.8 -2.0 -2.1 -2.5 -1.9 -2.1 -2.1 -0.3
Multivitamins +/- minerals 6.5 8.2 11.3 -3.2 2.2 3.4 2.7 3.1 2.3 2.2 3.3 2.7 3.2 -2.9
Stomach or abdominal pain in last month 0.6 0.7 2.9 -0.7 -0.0 1.7 1.2 0.7 0.3 0.2 1.1 0.6 1.1 -0.1
Supplements: Glucosamine 9.3 12.1 17.1 -3.2 3.5 2.9 3.3 3.7 4.1 1.2 4.1 3.9 3.9 -3.6
Diverticular disease/diverticulitis (self-reported) 1.1 1.2 2.2 -1.0 1.0 0.9 0.9 1.4 1.5 1.1 1.4 1.0 1.3 -0.2
Medication: Atenolol 0.4 0.5 1.6 0.0 -0.2 0.3 0.1 -0.3 -1.1 1.2 -0.5 -0.2 -0.3 1.3
Medication: Levothyroxine sodium 2.4 4.1 5.8 1.8 -1.7 -2.3 -2.1 -2.3 -2.4 -1.5 -2.2 -2.0 -2.2 1.5
Sitting height 0.3 2.0 5.8 -1.4 0.9 0.9 1.0 1.5 1.3 0.8 1.8 1.1 1.7 -2.4
Chronic bronchitis/emphysema (father) 1.3 1.6 5.0 -1.3 0.2 1.4 1.8 1.0 1.1 2.2 1.2 0.5 1.1 -0.7
High blood pressure (mother) 2.2 3.0 7.1 -2.7 2.4 2.3 1.9 1.1 0.7 0.6 1.6 1.9 1.8 -0.5
Body mass index (BMI) 2.1 8.8 14.9 -3.6 2.9 3.9 3.3 2.7 2.1 3.2 2.9 2.8 3.3 0.1
Impedance of leg (left) 0.2 1.0 2.2 1.3 -1.5 -1.0 -1.2 -0.7 -0.5 -0.7 -0.8 -1.1 -1.0 0.0
Leg predicted mass (left) 1.1 5.7 7.6 -2.7 2.7 2.3 2.2 2.4 2.3 1.7 2.7 2.4 2.8 -1.7
Trunk fat mass 1.4 6.1 7.9 -2.8 2.3 2.8 2.3 2.6 2.6 2.1 2.7 2.7 2.8 -1.0
Waist circumference 1.0 3.7 5.7 -2.3 1.9 2.4 2.0 1.7 1.3 1.8 2.0 2.1 2.2 -0.3
Number of incorrect matches in round 2.3 3.8 5.9 -1.7 0.3 1.9 2.4 2.4 1.4 2.4 2.3 1.6 2.2 -1.7
Past tobacco smoking 0.1 0.1 0.6 -0.1 0.3 -0.8 0.3 0.3 -0.1 0.2 0.1 -0.0 -0.1 -0.6
Alcohol usually taken with meals 0.3 0.4 1.8 0.6 -0.2 -0.9 -0.1 -0.8 0.3 -1.4 -0.3 -0.4 -0.6 -0.6
Nervous feelings 1.2 2.3 10.9 -0.9 0.1 0.6 1.3 1.9 1.5 -0.0 1.6 0.7 1.5 -3.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.1 0.9 0.5 0.6 -0.1 0.8 0.2 0.4 0.5 0.7 0.2
Hearing difficulty/problems with background noise 0.2 0.4 0.9 0.8 -0.8 -0.5 -1.0 0.0 0.1 -0.8 0.1 0.2 -0.0 -0.8
Hair/balding pattern: Pattern 2 2.9 3.6 6.7 -2.6 2.5 1.6 2.5 2.1 1.1 2.0 1.9 1.3 1.7 -0.7
Had menopause 0.4 0.6 1.3 0.6 -0.8 -1.0 -0.6 -0.4 -1.1 -1.1 -0.5 -0.3 -0.6 -0.4
Had other major operations 0.3 0.3 1.3 0.5 0.6 -0.5 -0.2 -0.5 -0.3 -0.6 -0.6 0.2 -0.6 1.1
Forced vital capacity (FVC) 0.7 2.7 7.4 -1.9 1.9 0.6 1.1 1.5 1.5 -0.7 1.5 1.9 1.4 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 5.5 1.6 -0.8 -0.4 -0.9 -1.1 -1.0 1.0 -1.4 -1.9 -1.2 2.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.5 0.3 0.0 -0.4 -0.4 -0.5 0.2 -0.4 -0.2 -0.2 -0.1 1.2
Qualifications: None of the above 0.9 1.9 3.9 -1.1 0.4 1.3 0.9 1.9 2.0 1.1 1.4 1.3 1.4 -1.5
Financial difficulties in last 2 years 0.2 0.3 1.0 -0.1 -0.0 0.9 -0.0 0.2 0.4 1.0 0.4 -0.0 0.7 0.7
Mouth/teeth dental problems 0.2 0.4 0.9 -0.9 1.0 -0.2 0.3 0.5 0.5 0.6 0.6 0.3 0.6 -0.9
Heart attack 0.3 0.4 0.8 0.8 -0.4 -0.4 -0.1 -0.7 0.5 -0.0 -0.5 -0.9 -0.6 0.9
Allergy 1.8 4.1 6.3 -2.0 2.2 2.5 2.0 2.0 2.0 2.4 1.9 2.0 2.1 0.3
Pain all over the body in last month 4.5 4.8 7.6 -2.4 1.6 2.7 2.5 2.8 1.8 1.1 2.2 2.4 2.5 -1.5
Diabetes (self-reported) 1.7 2.6 3.7 1.7 -1.9 -1.0 -1.8 -1.8 -1.8 -1.5 -1.7 -1.4 -1.7 1.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.8 -0.4 -0.6 -0.5 0.0 -0.1 -0.5 -0.7 -0.4 -0.4 -0.2 -1.3
Medication: Ramipril 1.8 2.3 5.5 1.1 -0.4 -1.5 -1.4 -1.9 -0.8 -1.4 -1.9 -1.2 -1.8 2.3
Medication: Simvastatin 0.3 0.4 0.8 -0.7 0.7 0.5 -0.0 0.4 0.4 0.9 0.7 0.9 0.6 0.4
Fluid intelligence score 0.7 1.5 2.2 1.3 -1.0 -1.1 -1.4 -1.5 -1.3 -0.6 -1.2 -1.3 -1.4 1.2
Illnesses of siblings 0.2 0.3 0.5 -0.4 0.7 0.7 0.5 0.5 0.6 -0.3 0.7 0.5 0.7 -0.4
Neuroticism score 0.6 1.2 2.4 0.1 -0.4 1.1 1.3 1.4 1.6 1.1 1.2 0.5 1.2 -1.3
Weight 2.2 10.8 14.9 -3.8 3.2 3.5 3.4 3.4 2.8 2.8 3.7 3.2 3.9 -2.0
Impedance of arm (right) 1.7 8.1 16.6 4.1 -3.9 -3.3 -3.3 -2.4 -1.0 -2.5 -2.7 -2.5 -2.9 0.8
Arm fat percentage (right) 1.2 4.7 7.2 -2.4 1.7 2.7 2.1 2.0 2.3 2.4 2.2 2.2 2.5 0.2
Trunk fat-free mass 1.1 6.5 9.2 -3.0 3.0 2.1 2.4 2.6 1.5 2.0 3.0 2.3 3.0 -2.8
Hip circumference 0.9 3.8 5.8 -2.4 1.6 2.0 2.0 1.8 1.8 2.2 2.1 1.9 2.2 -1.0
Time employed in main current job 3.0 3.4 7.1 -1.4 0.9 2.2 2.1 2.0 1.0 2.7 1.9 2.0 2.1 -1.3
Alcohol intake versus 10 years previously 0.2 0.3 1.1 -0.2 -0.1 0.8 0.3 0.2 -0.0 1.0 -0.0 -0.6 0.3 1.0
Father’s age at death 0.4 0.6 4.9 0.1 -0.8 -0.5 0.1 0.5 0.2 -0.3 0.2 -0.1 -0.2 -2.2
Worrier / anxious feelings 1.0 1.8 3.9 -0.7 1.0 1.0 1.4 1.8 1.9 2.0 1.4 0.7 1.4 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.5 1.2 -0.6 -0.7 -1.1 -0.6 -1.1 -0.6 -0.5 -0.6 -0.4 0.3
Falls in the last year 0.7 1.0 2.3 -1.2 1.5 1.3 1.0 0.8 -0.4 0.2 0.9 0.8 1.2 0.6
Hair/balding pattern: Pattern 3 0.4 0.6 2.6 0.6 -1.5 -0.1 -0.4 -0.6 0.1 -1.6 -0.0 0.1 -0.2 -1.1
Number of live births 1.1 1.6 2.9 1.2 0.3 -1.4 -1.3 -1.7 -0.9 -1.4 -1.1 -0.8 -1.3 1.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 6.3 -1.2 1.2 -0.2 0.5 0.7 0.9 -1.2 0.7 1.1 0.6 -2.5
Pulse rate 3.0 5.1 10.8 -2.5 3.3 2.6 2.8 2.0 2.0 0.2 2.4 2.2 2.2 -1.0
Happiness 0.2 0.2 0.6 -0.3 0.0 -0.8 0.1 0.6 0.5 -0.4 0.3 -0.3 0.3 -0.7
Noisy workplace 0.4 0.6 1.9 -1.1 1.0 0.9 0.2 -0.1 -0.4 -0.6 -0.0 0.7 0.3 1.4
Qualifications: A levels/AS levels or equivalent 1.0 2.1 5.5 1.1 -1.4 -1.3 -1.5 -1.7 -2.3 -1.7 -1.4 -0.8 -1.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.0 -0.8 1.2 1.4 0.7 0.5 1.1 -0.1 0.9 1.0 0.9 0.2
Mouth/teeth dental problems: Dentures 0.3 0.6 3.5 0.1 -0.2 0.5 -0.1 -0.5 -1.4 -0.4 -0.5 -0.0 -0.3 1.9
Asthma 1.0 1.9 3.5 1.3 -1.9 -1.1 -1.3 -1.5 -1.8 -1.5 -1.3 -1.0 -1.4 0.5
Medication: Ibuprofen (e.g. Nurofen) 3.0 3.9 7.5 -2.0 1.5 1.6 1.3 2.3 2.3 0.8 2.2 2.0 2.2 -2.7
Medication: Cholesterol lowering 0.2 0.3 1.7 -0.2 0.7 0.1 -0.3 -0.6 -0.2 -0.7 -0.2 0.6 -0.2 1.3
Depression (self-reported) 0.5 0.6 1.2 -0.7 0.3 1.0 0.5 1.0 0.2 0.8 1.1 0.4 1.1 -0.8
Medication: Lansoprazole 0.4 0.5 1.1 -0.7 0.1 1.1 0.9 1.0 0.1 0.5 0.7 0.6 0.9 -0.4
Prospective memory result 0.4 0.4 1.4 -0.8 0.9 -0.4 0.5 0.5 -0.7 1.2 -0.0 0.7 0.2 -0.5
Lung cancer (father) 1.4 1.6 3.3 1.6 -1.4 -0.7 -1.3 -1.1 -0.6 0.1 -1.4 -1.6 -1.2 1.8
Illnesses of mother 1.8 2.2 5.2 1.4 -0.7 -2.3 -1.4 -1.5 -1.2 -1.9 -1.4 -1.4 -1.7 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 8.3 -2.0 1.9 0.1 1.3 1.6 1.0 -0.3 1.3 1.7 1.4 -2.9
Pulse wave Arterial Stiffness index 2.7 3.1 6.1 -1.9 2.4 1.7 1.6 1.6 1.6 0.8 1.6 2.5 1.6 -1.5
Impedance of arm (left) 1.6 7.4 15.1 3.9 -3.4 -3.4 -3.1 -2.3 -0.8 -2.6 -2.5 -2.4 -2.9 0.5
Arm fat mass (right) 2.0 8.2 11.3 -3.4 2.8 3.3 2.9 2.8 2.6 2.8 3.1 2.8 3.4 -0.7
Trunk predicted mass 1.2 6.6 9.4 -3.1 3.0 2.1 2.4 2.6 1.5 2.0 3.0 2.3 3.0 -2.8
Standing height 0.3 3.0 18.9 -0.7 0.9 -0.7 0.3 1.7 1.3 -0.3 1.9 1.1 1.5 -4.3
Length of working week for main job 0.2 0.2 1.2 -0.5 -0.1 1.1 0.3 0.1 -0.1 -0.6 0.4 0.1 0.4 0.3
Exposure to tobacco smoke at home 0.5 0.6 2.7 0.3 -0.3 0.2 -0.9 -0.4 1.7 -1.5 -0.1 -0.0 -0.2 0.3
Breastfed as a baby 1.6 2.0 3.9 -1.4 1.5 0.6 0.5 1.5 1.6 1.3 1.6 1.8 1.2 -2.0
Tense / ‘highly strung’ 3.3 5.4 7.5 -1.8 1.5 2.4 2.6 2.6 2.3 2.7 2.7 1.7 2.6 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.5 -0.7 0.9 0.7 1.1 0.9 -0.3 0.8 1.1 0.5 1.2 0.1
Hair/balding pattern: Pattern 4 2.1 5.2 8.6 2.7 -2.1 -2.4 -2.3 -2.4 -2.1 -1.4 -2.3 -2.9 -2.4 1.6
Birth weight of first child 1.7 3.0 6.3 -1.9 1.2 2.5 1.6 1.9 1.4 0.9 1.7 2.4 1.5 -1.8
Peak expiratory flow (PEF) 0.4 1.0 4.6 -0.8 0.7 -1.2 -0.1 0.1 0.3 -1.6 0.1 0.8 -0.1 -2.1
Pulse wave reflection index 0.3 0.3 1.3 -0.8 0.2 0.0 0.1 0.2 0.9 0.2 0.2 1.0 0.2 -1.1
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.7 -1.6 1.6 0.8 0.4 0.9 0.8 0.7 1.4 1.3 1.2 -0.4
Loud music exposure frequency 0.5 0.6 1.7 0.9 -0.2 -0.9 -1.3 -0.7 -0.2 -0.9 -0.6 -0.8 -0.6 0.4
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.1 1.2 -0.9 -1.2 -1.5 -1.8 -1.7 -0.6 -1.6 -1.2 -1.3 1.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.7 0.7 -0.5 0.0 -0.1 0.3 0.8 0.2 0.2 0.2 0.2 -0.4
Blood clot in the leg (DVT) 0.9 1.2 2.8 0.6 -0.0 -1.1 -1.2 -1.6 -0.9 -1.7 -1.1 -0.4 -1.1 1.0
Medication: Paracetamol 0.4 0.7 1.4 -0.6 0.5 1.1 0.3 0.9 1.2 1.0 0.9 0.6 1.2 -0.1
Headache pain in last month 0.9 1.5 3.2 -1.0 1.2 1.6 1.4 1.2 0.6 0.8 1.8 0.8 1.7 -1.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.1 0.9 -0.9 -0.9 -0.1 -0.2 -0.5 0.2 -0.4 -1.1 -0.4 -0.4
Glaucoma (self-reported) 0.2 0.2 0.8 0.6 -0.7 -0.3 0.2 0.5 0.3 0.1 -0.0 -0.2 -0.1 -0.9
Gout (self-reported) 1.5 2.1 4.0 1.5 -1.1 -1.5 -1.6 -1.6 -1.2 -1.1 -1.4 -2.0 -1.2 1.1
Hypothyroidism/myxoedema (self-reported) 4.5 8.8 11.7 2.5 -2.5 -3.2 -3.1 -3.4 -3.2 -2.8 -3.4 -2.5 -3.3 2.3
Medication: Amlodipine 0.4 0.6 1.6 -1.3 0.0 1.0 0.8 0.9 0.5 0.1 0.7 0.6 0.7 -1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 -0.4 -0.5 0.5 0.6 0.4 -0.7 0.4 0.1 0.3 0.3 0.1
Birth weight 0.2 0.4 1.3 0.8 0.3 -1.1 -0.1 -0.8 -0.8 -0.3 -0.7 -0.5 -0.8 0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.7 -0.5 0.0 0.7 0.9 0.5 -1.2 1.6 -0.1 0.1 0.2 1.5
High blood pressure (siblings) 0.1 0.2 0.5 0.0 -0.5 -0.3 -0.1 -0.4 -0.7 0.5 -0.6 -0.2 -0.6 0.3
Forced vital capacity (FVC), Best measure 1.1 3.8 8.5 -2.4 2.4 0.8 1.6 2.0 1.6 -0.3 1.9 2.3 1.9 -2.9
Body fat percentage 1.6 6.2 9.8 -2.8 2.1 3.1 2.4 2.5 2.6 2.4 2.6 2.6 2.8 -0.3
Leg fat percentage (right) 2.4 8.7 15.9 -3.5 2.4 4.0 3.0 2.8 2.7 3.2 3.0 2.8 3.4 0.1
Arm fat-free mass (right) 1.9 9.5 14.4 -3.8 3.8 2.9 3.0 3.2 2.1 2.4 3.5 2.8 3.5 -2.6
Exposure to tobacco smoke outside home 0.2 0.3 1.5 -0.2 -0.8 -0.6 -0.3 0.4 0.1 -0.6 0.1 -0.5 0.2 -1.2
Comparative body size at age 10 0.4 1.0 2.8 -0.8 1.2 1.0 0.9 0.7 1.7 0.5 1.3 0.1 1.1 -0.8
Number of full brothers 0.4 0.4 1.6 0.1 0.6 -0.9 -0.5 0.3 0.9 1.3 0.1 -0.1 0.3 1.0
Worry too long after embarrassment 0.4 0.7 1.5 0.4 0.4 0.7 1.2 1.1 0.8 0.6 1.1 0.2 1.0 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.7 0.1 0.8 -0.3 0.3 0.1 -0.6 0.0 -0.0 -0.1 0.2 0.6
Wheeze or whistling in the chest in last year 1.1 1.9 4.3 1.5 -2.1 -0.7 -1.1 -1.9 -1.2 -1.3 -1.2 -1.0 -1.3 1.4
Number of children fathered 0.5 0.6 5.0 -0.0 1.0 0.3 -0.1 -0.3 0.2 -0.5 0.1 0.4 0.1 2.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 2.5 -0.7 0.9 1.1 1.2 1.1 1.6 1.4 1.2 0.6 1.2 -0.8
Age at first live birth 1.2 2.1 3.5 1.4 -1.5 -1.8 -1.9 -1.5 -0.9 -1.7 -1.3 -1.2 -1.6 -0.6
Pulse wave peak to peak time 2.3 2.8 5.6 1.9 -2.4 -1.6 -1.6 -1.4 -1.4 -0.7 -1.5 -2.4 -1.5 1.1
Health satisfaction 2.4 3.1 6.4 -1.6 2.5 1.7 1.5 1.9 1.8 0.8 2.0 1.8 2.2 0.4
Shortness of breath walking on level ground 0.1 0.2 1.0 0.0 -0.2 -0.1 -0.2 0.0 -1.0 0.2 -0.3 0.1 -0.1 0.8
Qualifications: College or University degree 1.2 3.7 6.2 1.8 -1.7 -2.1 -1.9 -2.5 -1.4 -2.1 -2.2 -1.7 -2.3 1.4
Eye problems/disorders: None of the above 0.6 0.7 2.9 0.5 -0.1 -0.4 -0.4 -0.8 -0.8 0.6 -0.9 -0.9 -0.7 1.7
Mouth/teeth dental problems: Loose teeth 1.7 2.1 5.5 1.6 -1.2 -1.1 -1.2 -1.6 -1.1 -0.7 -1.4 -1.6 -1.2 2.4
Emphysema/chronic bronchitis 2.2 2.5 6.6 1.7 -2.6 -1.2 -1.7 -1.5 -1.4 -1.8 -1.9 -0.8 -1.4 0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 3.6 1.5 -1.4 -1.6 -1.0 -1.9 -1.6 -0.4 -1.6 -1.5 -1.9 1.4
Neck or shoulder pain in last month 0.4 0.6 2.2 -0.5 0.2 1.5 1.3 0.5 0.5 -0.5 0.7 0.4 0.8 -0.6
Medication: Blood pressure 0.2 0.3 0.8 -0.8 0.8 0.9 0.5 0.3 0.6 -0.1 0.2 0.7 0.2 0.5
Angina (self-reported) 0.4 0.6 3.0 0.3 -0.9 0.0 -0.4 -1.2 0.2 -1.7 -0.6 -0.3 -0.7 -0.3
Migraine (self-reported) 0.4 0.5 3.6 -0.6 1.9 0.2 0.1 0.4 0.2 -0.4 0.7 0.4 0.5 0.4
Medication: Ibuprofen 3.2 3.8 7.2 -1.9 1.7 1.6 1.0 2.1 2.4 0.0 2.3 2.0 2.2 -2.7
Medication: Allopurinol 0.5 0.6 1.0 0.8 -0.7 -0.6 -1.0 -1.0 -0.5 -0.6 -0.9 -1.0 -0.8 0.5
Medication: Omeprazole 1.5 1.8 3.4 -1.1 0.6 0.8 1.1 1.7 1.8 1.0 1.5 1.3 1.4 -1.7
Medication: Seretide 50 evohaler 2.4 2.7 6.2 1.3 -2.5 -1.1 -2.0 -1.6 -1.8 -2.1 -1.5 -1.3 -1.6 0.5
Mean time to correctly identify matches 1.7 3.2 8.7 2.8 -3.0 -1.1 -2.1 -1.3 -1.4 -0.0 -1.6 -1.3 -1.5 1.7
Heart disease (mother) 0.6 0.7 2.6 -0.4 -0.5 1.6 0.9 0.7 1.0 0.6 0.7 0.4 0.9 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 0.7 -0.5 0.2 0.2 -0.4 0.1 -0.8 -0.6 -0.4 -0.6 0.3
Whole body fat mass 1.8 7.5 10.8 -3.2 2.5 3.3 2.7 2.8 2.7 2.4 3.0 2.8 3.2 -0.9
Leg fat mass (right) 2.7 10.4 15.4 -3.7 3.0 3.9 3.2 3.2 3.1 3.1 3.5 3.1 3.7 -0.7
Arm predicted mass (right) 1.7 8.5 13.3 -3.5 3.6 2.7 2.8 3.0 1.9 2.5 3.3 2.5 3.3 -2.4
Pulse rate, automated reading 4.7 15.2 23.1 -4.8 4.6 4.5 4.6 4.0 2.8 2.1 4.1 4.2 4.0 -1.9
Alcohol intake frequency. 0.1 0.1 0.9 0.3 0.1 0.6 -0.1 -0.0 0.0 -0.2 0.3 -0.3 0.3 0.9
Comparative height size at age 10 0.5 2.7 6.2 -0.8 1.2 0.9 1.2 2.2 1.8 0.9 2.3 1.0 1.9 -2.5
Number of full sisters 1.7 2.1 3.1 1.8 -1.2 -1.4 -1.6 -1.7 -0.5 -0.8 -1.6 -1.6 -1.5 1.7
Suffer from ‘nerves’ 1.7 2.6 6.7 -0.8 0.1 1.6 1.5 1.8 1.9 0.6 1.9 1.8 1.8 -2.6
Overall health rating 1.6 3.5 8.0 -1.7 1.3 2.8 2.2 2.0 1.3 1.3 2.2 1.6 2.4 -0.4
Chest pain or discomfort 1.8 2.6 8.3 2.1 -2.9 -0.8 -1.6 -1.6 -0.5 -2.0 -1.3 -1.5 -1.3 0.6
Had major operations 0.5 0.6 2.5 -0.4 1.6 0.9 0.5 0.3 -0.0 0.6 0.9 0.5 0.9 -0.3
Age at last live birth 0.7 1.0 3.4 0.9 -0.8 -1.8 -1.2 -0.8 -0.9 -1.3 -0.6 -0.7 -0.7 -0.6
Family relationship satisfaction 0.2 0.3 1.4 0.6 -0.0 -1.2 -0.5 -0.2 0.5 -0.9 -0.1 -0.3 -0.1 0.2
Leg pain on walking 3.1 3.9 6.3 -1.5 1.9 1.8 2.3 2.1 2.2 2.0 2.3 2.0 2.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.6 0.3 -0.1 -0.1 -0.4 -0.9 -0.3 1.2 -0.4 -0.5 -0.3 1.6
Commuting to job workplace: Car/motor vehicle 0.2 0.2 1.1 -0.8 0.1 -0.0 0.1 0.6 -0.1 0.4 0.1 0.3 0.1 -1.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.4 0.9 -1.1 -0.7 -0.4 -0.8 -1.6 0.4 -0.8 -0.5 -1.0 0.7
Medication: Aspirin 0.4 0.5 1.0 -0.7 0.6 0.7 0.4 0.4 0.8 -1.0 0.6 0.6 0.5 -1.0
Supplements: Vitamin C 2.8 3.3 6.0 -2.5 1.4 2.0 2.2 1.6 0.8 1.2 1.8 2.3 1.8 -1.6
Knee pain experienced in last month 8.9 13.9 22.1 -3.6 3.0 4.7 4.4 4.0 2.9 3.5 3.9 4.0 4.3 -1.6
Hypertension (Self-reported) 0.2 0.5 2.3 -0.3 0.8 0.6 0.4 0.0 0.5 1.5 -0.0 0.2 0.1 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.6 0.0 -0.8 0.2 0.1 0.2 -0.2 0.3 -0.0 -0.2 0.2 -0.3
Illnesses of father: Heart disease 0.7 1.0 2.0 0.6 -0.5 -1.1 -1.0 -1.2 -1.4 -1.3 -1.0 -0.7 -1.2 -0.1
Illnesses of siblings: Diabetes 0.5 0.6 1.2 0.8 -0.7 -0.9 -0.9 -0.6 -1.1 0.7 -0.6 -0.9 -0.5 0.9
Smoking status: Previous 0.1 0.2 0.6 -0.5 0.1 0.8 0.0 0.1 -0.5 0.2 0.2 0.6 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.4 -0.3 0.2 -0.5 0.3 0.5 0.6 0.6 0.8 0.1 0.7 -1.2
Whole body fat-free mass 1.3 7.3 10.4 -3.2 3.2 2.4 2.6 2.8 1.9 2.1 3.1 2.6 3.2 -2.4
Leg fat-free mass (right) 1.0 5.5 7.6 -2.7 2.8 2.1 2.2 2.4 2.1 1.5 2.7 2.4 2.7 -2.0
Arm fat percentage (left) 1.1 4.5 6.7 -2.4 1.8 2.6 2.1 2.0 2.5 2.3 2.1 2.1 2.3 0.2
Average weekly red wine intake 0.1 0.2 1.0 -0.1 0.9 -0.2 0.4 -0.2 1.0 0.2 0.1 -0.1 0.1 0.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 3.8 0.2 0.0 0.6 -0.1 0.2 -0.3 2.0 0.4 0.1 0.6 0.4
Mood swings 1.0 1.8 3.3 -0.9 0.2 1.2 1.8 1.8 1.5 0.6 1.4 1.4 1.3 -1.6
Loneliness, isolation 0.6 0.8 2.3 -0.6 0.3 1.1 1.2 0.8 1.5 0.3 0.6 1.1 0.7 -0.9
Long-standing illness, disability or infirmity 1.1 1.7 4.4 1.6 -2.1 -0.1 -0.9 -1.1 -1.1 0.1 -1.4 -1.0 -1.0 2.0
Ever had bowel cancer screening 0.7 0.9 2.1 1.0 -0.5 -1.4 -1.1 -0.7 -1.1 -1.2 -0.8 -0.4 -0.9 0.4
Diabetes diagnosed by doctor 2.2 3.5 6.0 1.9 -2.2 -1.6 -2.5 -2.0 -1.7 -1.8 -2.0 -1.6 -2.0 1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 3.8 0.9 0.1 -1.2 -1.1 -1.5 -1.0 -0.3 -0.9 -0.5 -1.0 1.9
Friendships satisfaction 0.2 0.2 0.6 -0.2 0.8 -0.4 0.1 0.4 0.6 -0.4 0.4 0.6 0.4 -0.3
Qualifications: nursing, teaching 2.7 4.2 7.2 1.7 -0.7 -1.9 -2.0 -2.7 -2.2 -1.9 -2.3 -2.2 -2.3 2.2
Commuting to job workplace: Walk 0.7 0.7 1.5 1.0 -1.2 -1.1 -0.5 -0.8 -0.6 -0.6 -1.0 -0.7 -1.0 -0.7
Eye problems/disorders: Cataract 0.7 0.8 2.3 1.0 -1.5 -0.9 -1.1 -1.0 -0.7 -0.9 -0.7 -0.6 -0.8 0.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.2 -1.6 0.1 1.9 1.8 1.7 0.9 0.3 1.6 1.4 1.5 -2.0
Medication for cholesterol 0.2 0.3 1.0 0.2 0.3 0.6 0.4 0.4 0.9 -0.0 0.4 0.5 0.3 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.6 0.1 -0.4 0.3 0.0 0.3 0.3 0.2 -0.2 -0.7 -0.2 -0.8
Back pain experienced in last month 1.4 2.0 3.2 -1.4 0.8 1.4 0.8 1.8 1.5 0.7 1.8 1.8 1.7 -1.3
Mineral and other dietary supplements 6.6 8.8 17.1 3.3 -1.9 -2.7 -2.5 -3.3 -2.9 -1.4 -3.3 -3.1 -3.3 4.1
Breast cancer (self-reported) 0.4 0.4 0.9 0.7 -0.8 0.1 0.0 -0.6 -0.9 -0.7 -0.6 -0.9 -0.3 0.8
Asthma (self-reported) 1.3 2.6 4.7 1.6 -2.2 -1.4 -1.4 -1.7 -2.0 -1.5 -1.6 -1.3 -1.7 0.7
Osteoporosis (self-reported) 0.7 0.8 2.0 0.7 -0.6 -0.9 -1.1 -1.2 -0.9 -1.4 -0.6 -0.2 -0.9 -0.7
Osteoarthritis (self-reported) 1.2 1.5 3.1 -1.1 -0.0 1.8 1.4 1.2 1.5 0.9 1.4 1.3 1.4 -0.7
Medication: Aspirin 0.4 0.5 1.7 -0.5 0.9 0.7 0.4 0.1 0.7 -1.3 0.6 0.5 0.4 -0.8
Medication: Gliclazide 0.3 0.3 1.1 -0.1 -0.7 0.0 0.2 0.4 -1.1 0.4 0.5 0.3 0.5 -1.0
Illnesses of father: None of the above (group 1) 0.2 0.3 1.7 0.3 -0.3 0.1 -0.1 -0.1 0.0 0.6 -0.4 -0.4 -0.3 1.3
Smoking status: Current 0.9 1.4 2.5 1.4 -0.5 -0.9 -1.3 -1.2 -1.0 -0.8 -1.1 -1.4 -1.3 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 4.0 -0.2 -0.2 -0.9 -0.5 -0.0 1.0 -1.7 -0.2 -0.2 -0.4 -2.0
Whole body water mass 1.3 7.2 9.9 -3.1 3.1 2.5 2.6 2.7 2.0 2.0 3.1 2.6 3.1 -2.5
Leg predicted mass (right) 1.0 5.1 7.2 -2.6 2.7 2.0 2.1 2.2 2.0 1.5 2.5 2.3 2.6 -1.9
Arm fat mass (left) 2.0 8.1 11.5 -3.4 2.7 3.2 2.9 2.8 2.7 2.7 3.1 2.8 3.3 -0.9
Number of self-reported non-cancer illnesses 0.0 0.1 0.2 -0.2 0.1 0.3 -0.1 0.1 0.0 0.1 0.2 0.5 0.1 0.5
Average weekly champagne plus white wine intake 0.3 0.4 1.1 0.2 -0.7 -0.5 -1.0 -0.9 -0.3 -0.6 -0.7 -0.5 -0.7 0.3
Miserableness 0.8 1.4 3.3 1.8 -1.5 -1.0 -1.3 -0.9 -0.0 -1.1 -1.1 -1.7 -1.0 0.8
Guilty feelings 1.3 2.0 8.2 0.1 0.6 0.7 1.2 1.6 2.0 2.9 1.4 0.4 1.7 -0.4
Wears glasses or contact lenses 1.6 1.9 3.7 1.7 -1.1 -1.9 -1.8 -1.2 -0.9 -1.1 -1.4 -1.2 -1.5 0.1
Ever taken oral contraceptive pill 1.1 1.2 2.8 0.7 -0.1 -1.2 -1.3 -1.5 0.1 -1.5 -1.0 -0.6 -1.1 1.7
Hearing aid user 0.6 0.7 3.2 0.6 -0.6 -0.3 -0.9 -1.1 -0.0 -1.8 -0.4 -1.0 -0.5 0.2
Mother’s age at death 0.2 0.3 1.2 -0.1 -0.7 0.2 0.1 0.5 1.1 0.5 0.5 0.2 0.6 -0.4
Financial situation satisfaction 0.2 0.3 0.9 -1.0 0.5 -0.1 0.6 0.5 -0.0 -0.2 0.5 0.8 0.8 -0.2
Tinnitus: Yes, now most or all of the time 2.8 3.3 6.6 1.9 -0.9 -1.4 -1.8 -2.2 -2.2 -0.6 -2.1 -1.5 -1.8 2.6
Commuting to job workplace: Public transport 1.5 1.7 4.4 1.0 -2.1 -0.8 -1.1 -1.3 -1.7 -1.7 -1.5 -0.7 -1.3 0.3
Eye problems/disorders: Glaucoma 0.1 0.1 0.6 0.5 -0.0 -0.5 0.2 0.2 0.1 -0.1 -0.4 -0.0 -0.4 -0.8
Medication: Blood pressure 0.2 0.3 1.1 -0.1 -0.5 -1.0 -0.5 -0.3 -1.0 -0.2 -0.6 -0.7 -0.5 0.2
Pain type(s) experienced in last month: Hip pain 1.2 1.6 3.6 -0.9 1.1 1.4 1.1 1.5 1.2 0.6 1.5 1.3 1.9 -0.7
Supplements: Fish oil (including cod liver oil) 7.1 9.2 15.8 -3.4 1.7 3.0 2.7 3.3 3.0 2.3 3.1 3.2 3.1 -4.0
High cholesterol (Self-reported) 1.0 1.7 4.3 -1.5 2.1 0.6 1.0 1.3 1.3 0.4 1.6 1.6 1.5 -0.3
Medication: Bendroflumethiazide 0.8 1.2 3.7 -1.8 0.8 0.7 0.8 1.3 0.6 0.2 0.9 0.9 0.9 -1.9
Medication: Paracetamol 1.7 2.7 5.4 -1.6 1.3 2.0 1.2 1.9 1.4 0.9 2.0 1.8 2.3 -0.8
Medication: Lisinopril 0.3 0.4 2.1 0.1 -0.1 -0.6 -0.5 -0.6 -1.1 -1.4 -0.4 0.1 -0.5 0.2
Medication: Atorvastatin 0.2 0.2 1.3 -0.2 0.4 -0.4 -0.1 -0.3 0.3 -0.7 -0.2 0.1 -0.1 1.1
Illnesses of father: High blood pressure 0.6 0.7 2.3 -0.7 1.5 0.2 0.7 0.6 0.7 -1.1 0.6 0.3 0.5 -1.4
Alcohol drinker status: Never 2.3 2.8 8.5 2.1 -1.0 -1.3 -1.1 -1.4 -1.4 -0.1 -1.8 -2.0 -1.5 2.9
Ever smoked 0.6 1.1 4.4 -0.6 0.3 2.1 1.1 0.7 1.5 0.1 1.1 0.8 1.1 -0.5
Basal metabolic rate 1.6 8.7 12.0 -3.5 3.4 2.8 2.8 3.0 2.3 2.3 3.4 2.8 3.5 -2.4
Leg fat percentage (left) 2.6 9.4 17.7 -3.7 2.6 4.2 3.1 2.9 2.7 3.1 3.1 2.9 3.4 0.1
Arm fat-free mass (left) 2.0 10.2 14.7 -3.8 3.8 3.2 3.1 3.2 2.2 2.6 3.6 2.9 3.7 -2.5
Number of operations (self-reported) 0.3 0.5 2.8 0.4 0.8 0.6 0.1 -0.7 -0.7 -0.1 -0.1 0.3 -0.0 1.7
Average weekly beer plus cider intake 1.0 1.4 3.3 -1.1 0.0 1.8 1.4 1.4 1.1 1.7 1.0 0.4 1.3 -0.0
Irritability 0.3 0.5 2.1 0.7 -1.4 0.7 0.1 0.1 0.9 1.0 -0.1 0.0 0.2 0.5
Risk taking 0.9 1.3 2.1 -1.1 1.4 1.3 0.9 1.0 0.9 1.2 1.3 1.1 1.3 0.2
Ever had prostate specific antigen (PSA) test 8.9 10.3 15.9 -3.1 2.4 3.4 2.8 3.4 4.0 2.9 3.6 3.1 3.5 -2.8
Fractured/broken bones in last 5 years 1.8 2.3 4.8 -1.6 2.2 1.7 1.9 1.6 1.1 0.3 1.5 1.4 1.4 -1.1
Age started oral contraceptive pill 0.1 0.1 0.2 0.1 -0.2 -0.1 0.2 0.4 -0.1 0.4 0.2 0.4 0.4 -0.3
Diastolic blood pressure, automated reading 1.9 5.7 11.2 -3.4 3.0 2.0 2.5 2.5 1.4 2.1 2.1 2.6 2.3 -1.8
Ever depressed for a whole week 0.3 0.4 2.4 0.2 0.1 -0.6 -0.7 -0.6 -1.6 -0.3 -0.4 0.0 -0.2 0.8
Unable to work because of sickness or disability 0.3 0.4 1.3 0.7 -0.7 -0.2 -0.2 -0.7 -0.5 -0.4 -0.7 -0.6 -0.6 1.1
Commuting to job workplace: Cycle 0.6 0.7 2.5 0.5 -0.3 -1.0 -0.8 -1.0 -0.6 -1.6 -0.7 -0.9 -0.8 0.1
Myopia 0.4 0.5 3.3 -0.2 0.6 0.1 -0.5 0.2 0.6 1.8 -0.0 0.6 0.1 0.9
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.9 0.8 -1.0 -0.7 -0.4 -0.1 -0.7 -0.8 -0.4 -0.7 -0.5 -0.9
Cholesterol lowering medication 0.4 0.6 1.9 -1.0 0.8 0.2 0.4 0.7 0.4 1.4 0.8 0.7 0.8 0.4
Medication: Omeprazole (e.g. Zanprol) 2.4 3.0 4.9 -1.3 1.3 1.2 1.7 2.2 2.1 1.9 1.9 1.5 2.1 -1.1
Pain experienced in last month 5.0 8.3 15.6 2.3 -2.4 -3.9 -3.0 -3.0 -2.6 -1.7 -3.6 -3.0 -3.6 1.5
Supplements: Calcium 0.6 0.7 1.4 -1.1 0.9 0.8 0.8 0.6 0.8 -0.6 0.9 0.7 0.7 -1.2
Basal cell carcinoma (self-reported) 0.3 0.4 0.7 -0.5 0.3 0.0 0.5 0.7 0.7 0.5 0.7 0.7 0.6 -0.9
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.2 0.9 -0.3 -0.4 -0.1 -0.8 0.6 -0.2 -0.6 -0.9 -0.6 1.1
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 3.5 0.9 0.0 -1.1 -1.2 -1.8 -0.9 -1.9 -1.3 -0.7 -1.3 1.4
Heart disease (siblings) 0.1 0.2 1.0 -0.3 -0.3 0.5 0.2 0.2 -0.0 1.0 0.4 -0.1 0.3 0.2
Alcohol drinker status: Previous 0.3 0.3 1.4 -0.5 1.2 0.3 0.2 0.0 -0.3 -1.0 0.6 0.3 0.5 -0.2
Pack years of smoking 4.1 6.0 8.5 2.5 -2.2 -2.5 -2.9 -2.8 -1.8 -1.8 -2.8 -2.3 -2.8 2.3
Impedance of whole body 0.8 4.1 8.2 2.9 -2.7 -2.5 -2.4 -1.5 -0.7 -2.1 -1.8 -1.9 -2.1 0.1
Leg fat mass (left) 2.8 11.0 16.9 -3.9 3.1 4.1 3.3 3.3 3.1 3.1 3.6 3.2 3.8 -0.8
Arm predicted mass (left) 2.1 10.8 15.8 -4.0 3.8 3.2 3.2 3.3 2.2 2.9 3.7 3.0 3.8 -2.5