TWAS hub - MAPK1IP1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0230	0.0045	0.000	0.009	0.001	0.008	-0.001	3.5e-01	0.022	0.250	0.034	0.3800
2	GTEx	Cells Transformed fibroblasts	0.0520	0.0270	0.0071	0.053	NA	0.017	NA	0.022	7.9e-05	NA	0.018	NA	0.0087
3	GTEx	Esophagus Mucosa	0.0950	0.0480	0.0052	0.005	NA	0.020	NA	0.022	1.5e-01	NA	0.017	NA	0.0120
4	GTEx	Nerve Tibial	0.0762	0.0360	0.0064	-0.002	NA	0.010	NA	0.017	5.2e-01	NA	0.056	NA	0.0210
5	METSIM	Adipose	0.0283	0.0134	0.0022	0.005	0.005	0.002	0.006	0.002	5.4e-02	0.043	0.170	0.042	0.1500

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Knee pain experienced in last month	9.2	14.2	22.4	-3.4	-3.9	-2.4	-4.1	-4.7
Pain experienced in last month	8.3	13.8	34.3	5.9	3.4	0.4	3.8	2.9
Vitamin and mineral supplements	8.1	10.9	20.7	2.8	4.5	0.3	4.2	2.9
Supplements: Glucosamine	7.5	9.8	14.8	-3.8	-3.8	-0.8	-3.9	-2.2
Blood Eosinophil Count	7.3	56.3	95.1	5.9	9.8	5.1	8.5	7.4
Leg pain on walking	5.3	6.6	13.6	-3.7	-2.4	-1.8	-2.5	-2.2
Blood Platelet Count	4.6	52.9	85.0	4.5	8.1	3.5	9.2	9.0
Health satisfaction	4.6	6.0	12.9	-3.6	-2.0	-1.0	-2.4	-2.5
Ever had prostate specific antigen (PSA) test	4.4	5.0	12.0	-1.9	-3.5	-0.8	-2.3	-1.8
Pulse rate, automated reading	4.2	13.5	18.0	-0.3	-3.9	-4.0	-4.2	-4.2
Mineral and other dietary supplements	4.0	5.4	11.2	2.5	3.3	0.9	2.7	1.1
Multivitamins +/- minerals	3.9	4.9	10.7	-2.0	-3.3	-0.2	-2.7	-1.6
Pain type(s) experienced in last month: Hip pain	3.6	4.6	13.6	-3.7	-1.6	-1.6	-1.4	-1.5
Pack years adult smoking proportion	3.5	5.3	9.9	2.5	3.2	1.1	2.4	2.0
Pain all over the body in last month	3.5	3.8	6.0	-2.0	-2.4	-0.6	-2.1	-2.0
Supplements: Fish oil (including cod liver oil)	3.5	4.5	9.9	-1.7	-3.1	-1.8	-2.1	-1.5
Pulse wave peak to peak time	3.3	3.9	9.9	0.9	1.3	3.1	1.8	2.0
Leg fat percentage (left)	3.0	11.0	20.6	-3.1	-3.0	-2.7	-2.9	-4.5
Medication: Paracetamol	2.9	4.5	10.9	-3.3	-2.2	-0.6	-1.9	-1.7
Pulse rate	2.8	4.8	8.2	-0.9	-2.1	-1.7	-2.7	-2.9
Leg fat percentage (right)	2.8	10.1	18.8	-3.2	-2.9	-2.5	-2.5	-4.3
High blood pressure (mother)	2.7	3.8	9.7	0.1	-1.9	-3.1	-1.5	-1.9
Pulse wave Arterial Stiffness index	2.7	3.1	6.8	-0.9	-1.4	-2.6	-1.7	-1.8
Mean Putamen Volume	2.6	3.0	6.5	2.6	-0.6	-2.2	-1.3	-1.2
Average weekly spirits intake	2.6	3.2	4.2	-1.4	-1.7	-2.1	-1.7	-2.0
Pack years of smoking	2.6	3.8	7.6	2.1	2.8	0.2	2.1	1.7
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	11.0	2.3	3.3	0.9	1.9	1.6
Age at First Birth	2.3	3.3	6.5	1.3	1.6	0.0	2.3	2.6
BMI	2.3	13.3	23.5	-2.1	-3.9	-3.5	-3.2	-4.9
Fractured/broken bones in last 5 years	2.3	3.0	8.3	-1.6	-1.5	-0.4	-2.9	-1.2
Leg fat mass (left)	2.3	9.0	15.8	-2.1	-3.5	-2.2	-2.8	-4.0
Body mass index (BMI)	2.2	9.2	19.2	-1.6	-2.9	-3.3	-2.4	-4.4
Leg fat mass (right)	2.2	8.3	14.8	-2.2	-3.4	-2.1	-2.5	-3.9
Overall health rating	2.2	4.7	6.5	-2.3	-2.3	0.8	-2.4	-2.5
Supplements: Vitamin C	2.2	2.5	3.5	0.5	-1.8	-1.9	-1.7	-1.7
Current tobacco smoking	2.1	3.4	9.6	1.7	1.5	3.1	1.3	0.8
Time employed in main current job	2.1	2.4	4.7	-1.3	-1.9	-0.5	-1.3	-2.2
Noisy workplace	2.1	2.6	7.6	-0.3	-0.1	-2.8	-1.2	-2.0
Tense / ‘highly strung’	2.1	3.6	6.4	-2.0	-2.5	0.5	-2.2	-1.5
Headache pain in last month	2.1	3.6	10.1	-3.2	-1.7	0.0	-2.0	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	5.4	-2.3	-1.9	-1.2	-1.4	-0.7
Impedance of arm (right)	2.0	9.5	19.2	1.0	2.6	4.4	2.8	3.5
Smoking status: Current	2.0	3.1	9.2	1.6	1.3	3.0	1.2	0.8
Guilty feelings	2.0	3.1	11.4	-3.4	-1.3	1.3	-0.6	-0.4
Hypothyroidism (self reported)	1.9	4.3	10.2	2.0	3.2	1.1	2.0	1.5
Medication: Levothyroxine sodium	1.9	3.2	4.9	2.0	2.2	1.2	1.8	1.5
Medication: Ibuprofen	1.9	2.2	5.2	-1.3	-2.3	-0.9	-1.8	0.2
Commuting to job workplace: Public transport	1.9	2.2	6.2	2.5	1.2	-0.4	1.7	0.6
Blood Red Count	1.8	17.5	26.1	3.9	3.8	2.7	5.1	4.9
Blood White Count	1.8	13.3	30.3	0.9	5.5	4.1	4.0	1.7
Average weekly fortified wine intake	1.8	2.1	5.9	0.5	0.4	2.4	1.8	0.9
Falls in the last year	1.8	2.5	4.5	-2.1	-1.1	-0.9	-2.0	-1.4
Impedance of arm (left)	1.8	8.3	14.9	1.0	2.6	3.9	2.5	3.5
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.8	-1.1	-1.3	-1.2	-2.0	-1.6
Intelligence (Savage-Jansen 2018)	1.7	5.1	6.9	2.1	2.6	2.6	1.3	2.5
Lung FEV1/FVC ratio	1.7	8.7	17.9	2.6	2.2	2.8	2.5	4.2
Hair/balding pattern: Pattern 2	1.7	2.1	4.8	-0.7	-1.9	0.2	-2.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.7	-1.1	-2.2	-1.2	-1.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.8	-2.4	-1.1	-1.3	-1.7	-1.2
Age at first live birth	1.7	3.0	8.4	1.9	1.3	0.8	0.8	2.9
Prostate Cancer	1.6	2.2	4.5	-1.1	-1.0	-0.2	-2.1	-2.1
Migraine (self-reported)	1.6	1.9	5.1	-2.3	-0.6	1.4	-1.2	-0.8
Diastolic blood pressure, automated reading	1.6	5.0	7.1	2.4	-2.2	-2.4	-1.4	-2.7
Neuroticism (2016)	1.5	2.2	8.9	-3.0	-1.2	0.1	-0.5	0.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.4	0.2	1.8	0.6	1.0	1.8
Serious illness, injury or assault to yourself	1.5	1.8	3.8	-0.7	-0.6	-0.9	-2.0	-1.8
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.1	1.4	1.9	-0.5	2.0	2.5
Allergy	1.5	3.4	6.2	-1.3	-2.0	0.8	-2.1	-2.5
Worrier / anxious feelings	1.5	2.7	6.7	-2.6	-1.1	2.1	-0.8	-0.8
Arm fat mass (right)	1.5	6.3	11.5	-1.5	-3.0	-2.1	-2.0	-3.4
Hair/balding pattern: Pattern 4	1.5	3.7	6.1	0.6	2.5	0.9	2.5	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.4	-1.7	0.1	-2.1	-0.8	-1.4
Back pain experienced in last month	1.5	2.3	4.5	-2.1	-1.7	-0.9	-1.4	-1.1
Arm fat mass (left)	1.5	6.0	11.7	-1.3	-2.9	-2.1	-2.0	-3.4
Wears glasses or contact lenses	1.5	1.8	3.4	1.0	1.6	-0.1	1.4	1.8
Crohns Disease (2017)	1.4	3.0	7.0	-0.8	-1.2	-2.6	-1.2	-2.1
Reaction Time	1.4	2.6	4.9	-0.8	1.4	1.3	2.0	2.2
Systolic Blood Pressure	1.4	7.1	19.4	4.4	2.7	-0.9	2.6	1.0
Medication: Co-codamol	1.4	1.6	4.2	-2.1	-1.3	0.6	-1.1	-0.7
Prospective memory result	1.4	1.7	7.3	0.7	-0.1	-2.7	0.2	-0.8
Body fat percentage	1.4	5.6	10.8	-2.0	-2.5	-1.6	-2.0	-3.3
Number of children fathered	1.4	1.6	4.2	-2.1	0.0	-0.7	-0.9	-1.5
Number of full sisters	1.4	1.7	3.0	0.0	1.7	1.7	1.2	1.1
Commuting to job workplace: Walk	1.4	1.5	3.3	1.8	1.0	-0.0	1.4	1.1
Ever smoked	1.4	2.4	4.4	-2.1	-1.0	0.2	-1.9	-1.8
Risk taking	1.4	2.1	5.0	-2.2	-1.3	-0.2	-1.6	-1.1
Chronotype (morning person)	1.3	3.1	4.5	-0.7	1.9	2.1	1.9	1.8
Relative age voice broke	1.3	2.0	2.8	1.6	1.7	0.7	1.4	1.4
Medication: Ramipril	1.3	1.7	3.7	1.3	1.9	-1.1	1.3	-0.0
Weight	1.3	6.3	13.2	-1.1	-3.6	-1.9	-2.3	-2.9
Lung cancer (father)	1.3	1.5	4.1	-0.1	1.2	2.0	0.9	1.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.8	2.4	1.3	0.3	1.4	1.0
Medication for pain relief, constipation, heartburn	1.3	2.3	4.0	2.0	1.7	0.5	1.4	1.5
Whole body fat mass	1.3	5.3	9.3	-1.3	-2.8	-1.7	-2.1	-3.1
Chest pain or discomfort	1.3	1.9	3.3	-1.1	1.2	1.8	0.7	1.7
Qualifications: nursing, teaching	1.3	2.1	4.9	1.9	2.2	0.1	0.9	0.9
Worry (Nagel 2018)	1.2	2.6	6.5	-2.5	-2.2	0.3	-1.3	-0.2
Bipolar Disorder (2011)	1.2	1.2	4.9	-2.2	0.2	-0.9	-0.3	0.0
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.1	-1.8	-1.1	-0.8	-1.3	0.1
Fed-up feelings	1.2	2.2	5.9	-2.4	-1.3	0.2	-1.5	-1.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.6	1.5	1.6	0.4	1.1	0.9
Medication: Atenolol	1.2	1.5	3.0	1.7	0.4	-1.6	0.4	-1.4
Qualifications: College or University degree	1.2	3.8	8.3	2.9	2.0	0.4	2.2	1.2
Medication: Omeprazole	1.2	1.5	3.0	-1.7	-1.4	-1.3	-0.8	0.2
Mean time to correctly identify matches	1.2	2.3	4.2	-0.7	1.7	0.7	2.0	1.8
Diabetes diagnosed by doctor	1.2	2.0	3.9	1.1	2.0	-1.3	1.4	1.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.4	1.5	1.8	0.2	1.1	-0.2
Fasting Glucose	1.1	1.4	4.7	2.2	0.8	-0.2	0.8	0.8
Relative age of first facial hair	1.1	2.2	6.2	2.5	1.5	-0.5	0.9	1.2
Townsend deprivation index at recruitment	1.1	1.5	3.2	-1.6	-0.9	-0.6	-0.8	-1.8
Age when periods started (menarche)	1.1	2.7	4.8	-0.4	1.9	2.2	1.6	1.6
Stomach or abdominal pain in last month	1.1	1.4	2.4	-1.4	-1.0	-1.1	-1.5	-0.6
Number of incorrect matches in round	1.1	1.8	4.9	-1.3	-2.2	-1.0	-1.0	-0.8
Arm fat percentage (right)	1.1	4.3	10.2	-1.4	-2.1	-1.7	-1.3	-3.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.2	-1.1	-0.9	-0.4	-1.4	-1.5
Birth weight of first child	1.1	1.9	2.8	-0.2	-1.6	-1.6	-1.7	-1.3
Medication: Seretide 50 evohaler	1.1	1.2	2.2	1.3	1.5	0.7	0.8	1.1
Family relationship satisfaction	1.1	1.4	5.1	-2.2	0.2	1.0	-0.8	-0.4
Mood swings	1.1	2.0	6.0	-2.4	-1.2	0.3	-1.5	-0.5
Ever had bowel cancer screening	1.1	1.2	2.3	-1.5	0.9	-0.8	0.2	1.5
Osteoarthritis (self-reported)	1.1	1.5	2.1	-1.0	-1.2	-0.9	-1.4	-1.3
Alcohol drinker status: Never	1.1	1.3	2.9	-0.2	1.7	1.3	1.4	-0.0
Arm fat-free mass (left)	1.1	5.4	12.7	-0.6	-3.6	-2.0	-2.3	-2.2
Impedance of whole body	1.1	5.7	13.6	-0.3	1.8	3.7	1.6	3.0
Arm predicted mass (left)	1.1	5.7	13.6	-0.6	-3.7	-2.0	-2.3	-2.3
Schizophrenia vs Biploar Disorder	1.0	1.3	4.0	-0.9	-0.2	2.0	-1.1	0.6
Primary Biliary Cirrhosis	1.0	1.4	3.0	-0.5	-1.6	-1.7	-1.0	-0.2
Number of treatments/medications taken	1.0	1.8	4.0	-0.8	-1.3	-1.3	-2.0	-0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.5	-1.6	-1.5	0.1	-0.4	-1.1
Waist circumference	1.0	3.6	8.4	-1.0	-1.9	-1.6	-1.5	-2.9
Nervous feelings	1.0	1.9	3.9	-2.0	-1.6	1.0	-1.1	0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.4	0.6	0.3	-2.3	-0.0	0.7
Happiness	1.0	1.3	2.9	-1.7	-0.5	1.5	-0.7	0.6
Depression (self-reported)	1.0	1.2	1.9	-1.2	-1.0	-1.2	-1.4	-0.0
Worry too long after embarrassment	1.0	1.6	4.0	-2.0	-0.9	1.2	-1.3	-0.3
Emphysema/chronic bronchitis	1.0	1.2	2.3	0.5	1.5	-0.4	1.4	1.0
Neck or shoulder pain in last month	1.0	1.4	3.4	-1.8	-0.6	0.6	-1.5	-0.7
Suffer from ‘nerves’	1.0	1.6	3.2	-1.6	-1.8	-0.9	-1.2	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.8	1.3	0.8	0.9	1.4	0.9
Smoking status: Previous	1.0	1.4	3.7	-1.9	-0.4	0.3	-1.2	-1.3
Arm fat percentage (left)	1.0	4.1	9.9	-1.4	-2.0	-1.8	-1.3	-3.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.9	-0.9	-1.5	0.3	-2.0	-0.9
Financial situation satisfaction	1.0	1.3	2.6	-1.1	-0.7	-1.6	-0.5	-1.3
High cholesterol (Self-reported)	1.0	1.8	3.1	-1.3	-1.4	0.1	-1.8	-1.4
Supplements: Calcium	1.0	1.1	3.5	-1.1	-0.8	0.4	-1.9	-0.1
Trunk fat percentage	0.9	3.7	7.5	-1.6	-2.0	-1.3	-1.7	-2.7
Trunk fat mass	0.9	3.8	6.5	-1.2	-2.5	-1.3	-1.7	-2.6
Hearing difficulty/problems with background noise	0.9	1.4	4.3	-2.1	-0.1	-0.7	0.1	1.5
Neuroticism score	0.9	2.0	5.8	-2.4	-1.1	1.4	-1.0	-0.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.2	2.3	1.3	0.4	1.4	0.9
Illnesses of mother	0.9	1.1	2.3	0.2	1.5	1.3	0.5	1.1
Breastfed as a baby	0.9	1.1	2.6	-0.5	-1.3	-1.6	-1.0	0.2
Medication: Amlodipine	0.9	1.3	4.8	0.6	-0.8	-2.2	-0.9	-0.3
Arm fat-free mass (right)	0.9	4.5	11.6	-0.6	-3.4	-1.6	-2.1	-1.9
Number of full brothers	0.9	1.2	4.7	-2.2	-0.1	0.8	0.7	-0.2
Eye problems/disorders: None of the above	0.9	1.0	1.6	1.1	0.9	1.3	1.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.4	-0.6	1.4	1.5	-0.1	-0.7
Age at last live birth	0.9	1.3	4.8	1.0	0.5	-0.6	0.5	2.2
Illnesses of father: Heart disease	0.9	1.2	3.7	1.9	1.0	0.4	0.4	1.1
Medication: Bendroflumethiazide	0.9	1.3	4.5	0.7	-1.1	-2.1	-0.5	-0.3
Irritable Bowel Disease (IBD)	0.8	1.9	2.6	-1.2	-1.3	-1.6	-1.1	-1.6
Smoking Status	0.8	1.9	8.3	-0.2	0.8	2.9	-0.4	-0.8
Sensitivity / hurt feelings	0.8	1.3	2.7	-1.6	-0.7	1.4	-1.2	0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	-0.9	1.5	1.5	-0.4	0.0
Systolic blood pressure, automated reading	0.8	2.3	5.5	2.3	0.7	-2.3	0.5	-0.4
Angina	0.8	1.1	3.8	2.0	0.6	-0.5	0.1	0.9
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	0.3	-1.0	-1.5	-0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.2	-0.8	-0.5	1.5	-0.3	-1.8
Diabetes (self-reported)	0.8	1.2	2.9	1.2	1.7	-0.8	0.9	0.6
Fluid intelligence score	0.8	1.6	4.0	0.9	1.2	2.0	0.6	1.2
Medication: Paracetamol	0.8	1.4	5.0	-2.2	-1.0	0.1	-0.6	-0.8
Gout (self-reported)	0.8	1.0	1.7	1.1	1.3	1.0	0.9	0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.1	4.1	-0.1	-0.1	-2.0	-0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.6	0.9	-0.0	-1.0	-0.5	-1.6
Arm predicted mass (right)	0.8	4.0	10.7	-0.4	-3.3	-1.5	-2.0	-1.7
Illnesses of siblings: Diabetes	0.8	1.0	2.3	1.5	0.4	1.0	1.1	0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.7	-1.6	-0.6	1.0	0.4	-0.9
Asthma (self-reported)	0.8	1.5	2.7	1.5	1.6	0.4	1.2	1.0
Alzheimer’s Disease (in father)	0.7	0.8	1.9	-0.4	0.1	-0.8	1.4	1.2
Body Mass Index (BMI) (2010)	0.7	0.9	1.8	-0.1	-1.3	-1.1	-1.0	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	1.8	1.0	0.5	1.3	-0.9	0.0
Crohns Disease (2012)	0.7	1.2	5.5	0.4	-0.1	-2.3	-0.2	-0.6
Rheumatoid Arthritis	0.7	0.9	1.8	-1.4	-0.1	-1.1	0.2	1.2
Triglycerides	0.7	1.2	4.1	2.0	0.6	0.5	0.7	0.9
Allergy or Eczema	0.7	1.8	3.4	0.9	1.2	-0.8	1.6	1.9
Hearing difficulty/problems: Yes	0.7	1.1	2.1	1.5	0.9	-1.2	0.9	0.6
Past tobacco smoking	0.7	1.3	3.1	1.8	-0.0	-0.9	1.1	1.1
Qualifications: None of the above	0.7	1.4	3.0	-1.7	-1.4	-1.0	-0.9	-0.6
Exposure to tobacco smoke outside home	0.7	1.0	2.7	-1.4	-0.3	0.4	0.0	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	-1.4	-1.2	-0.6	-0.6	-0.4
Angina (self-reported)	0.7	1.0	3.6	1.9	0.6	-0.4	0.0	0.8
Ever taken oral contraceptive pill	0.7	0.8	1.4	0.8	1.2	-0.9	0.9	0.3
Illnesses of father: High blood pressure	0.7	0.9	2.5	1.6	-0.6	-0.1	-1.0	0.6
Basal metabolic rate	0.7	4.0	11.0	-0.1	-3.3	-1.5	-1.8	-1.9
Number of operations (self-reported)	0.7	1.0	2.4	-0.5	0.1	1.4	-0.6	-1.5
Average weekly beer plus cider intake	0.7	1.1	1.5	-0.5	-1.1	-1.2	-1.0	-1.2
Basal cell carcinoma (self-reported)	0.7	0.9	3.7	-0.4	-0.7	-1.9	-0.3	-0.1
Alcohol drinker status: Previous	0.7	0.8	1.7	-0.5	-0.4	-1.2	-1.3	-0.4
LDL Cholesterol	0.6	0.9	2.7	1.6	0.7	0.6	0.9	0.5
Waist Hip Ratio (WHR)	0.6	2.5	4.4	-2.1	-0.5	1.4	-1.8	-1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.5	0.6	1.1	-1.9	0.6	0.4
Tanning	0.6	7.1	15.8	0.4	-1.9	-2.9	-2.8	-4.0
Severe depression (siblings)	0.6	0.6	1.5	-0.0	1.1	1.2	-0.1	0.6
Impedance of leg (right)	0.6	2.9	8.1	-1.5	0.8	2.8	0.7	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.2	0.5	2.0	-0.5	1.3	0.6
Qualifications: CSEs or equivalent	0.6	0.8	1.9	-0.6	-1.1	0.1	-1.4	-0.5
Impedance of leg (left)	0.6	2.9	8.7	-1.5	0.7	2.9	0.4	1.6
Mouth/teeth dental problems	0.6	0.9	2.0	1.2	-0.7	-1.4	0.3	0.4
Illnesses of siblings	0.6	0.9	2.2	-1.5	-0.7	-0.8	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	-1.4	0.5	0.3	-0.9	-1.4
Asthma	0.6	1.2	2.5	1.6	1.4	0.2	0.9	0.9
Medication: Lansoprazole	0.6	0.7	1.3	-1.1	-0.9	0.5	-0.8	-0.6
Peak expiratory flow (PEF)	0.6	1.4	3.0	1.7	-0.1	-0.4	1.2	1.6
Pulse wave reflection index	0.6	0.8	3.9	-0.0	-0.1	-2.0	-0.1	0.0
Medication: Blood pressure	0.6	1.1	2.1	0.9	-0.2	-1.1	-1.1	-1.4
Had major operations	0.6	0.7	1.2	0.4	-0.9	0.7	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.8	0.3	-0.8	1.7	0.8	1.5
Friendships satisfaction	0.6	0.8	2.2	-1.1	-0.4	-0.4	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.9	0.4	0.2	-1.3	0.4	2.0
Whole body water mass	0.6	3.2	9.3	0.1	-3.0	-1.3	-1.6	-1.5
Average weekly champagne plus white wine intake	0.6	0.8	2.9	1.7	0.5	-0.6	0.2	0.8
Bipolar Disorder (2018)	0.5	0.8	3.4	-0.3	-0.3	-1.8	0.1	0.6
Neuroticism (Nagel 2018)	0.5	1.1	4.3	-2.1	-0.7	0.7	-0.7	0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-0.1	-0.5	-0.6	1.2	1.1
Height	0.5	9.8	30.6	1.8	-1.1	3.5	1.5	5.5
Lung FVC	0.5	2.6	7.0	-1.1	0.4	-2.6	-0.7	-2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	-1.1	0.3	0.1	-0.6	-1.3
Leg fat-free mass (left)	0.5	2.7	6.8	0.4	-2.6	-1.3	-1.4	-1.7
Leg predicted mass (left)	0.5	2.7	6.8	0.3	-2.6	-1.3	-1.4	-1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	-1.1	0.2	0.4	-0.4	-1.3
Hip circumference	0.5	2.1	4.0	0.2	-2.0	-1.6	-0.6	-1.9
Father’s age at death	0.5	0.7	2.9	0.8	0.0	-0.1	0.2	1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-0.9	0.4	0.4	1.1	1.2
Forced vital capacity (FVC), Best measure	0.5	2.0	4.0	-0.8	-2.0	-1.6	-1.6	-0.3
Whole body fat-free mass	0.5	3.1	9.4	0.2	-3.1	-1.3	-1.5	-1.5
Leg fat-free mass (right)	0.5	2.6	6.7	0.6	-2.6	-1.3	-1.5	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.3	1.0	1.1	0.5	-0.6
Breast cancer (self-reported)	0.5	0.6	2.4	1.5	0.5	0.7	0.1	-0.3
Leg predicted mass (right)	0.5	2.4	6.1	0.7	-2.5	-1.3	-1.4	-1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.7	0.2	1.2	1.7	-0.0	0.1
Ovarian Cancer	0.4	0.5	2.4	-0.4	-0.2	-0.2	-0.1	-1.6
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.6	-0.5	-0.6	-0.8	-0.5	0.8
Ulcerative Colitis	0.4	0.5	1.5	-1.2	-0.7	-0.1	-0.4	0.7
Heel T-Score	0.4	2.9	5.1	1.2	1.8	-2.0	2.2	1.0
Neuroticism	0.4	1.0	2.3	-1.5	-0.8	0.9	-0.2	1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-1.2	-0.2	0.6	-0.7	-0.5
Medication for hormone replacement therapy	0.4	0.4	0.7	-0.6	0.8	0.6	0.1	-0.7
Medication: Metformin	0.4	0.5	1.2	1.0	1.1	-0.2	0.3	-0.3
Diabetes (mother)	0.4	0.5	1.0	0.9	-1.0	0.3	-0.5	-0.6
Maternal smoking around birth	0.4	0.6	1.2	0.8	1.1	0.2	0.9	0.3
Had menopause	0.4	0.5	1.3	-0.7	0.5	0.7	0.0	1.1
Trunk fat-free mass	0.4	2.4	8.8	0.4	-3.0	-0.9	-1.2	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-0.2	0.0	-0.9	1.0	1.0
Number of live births	0.4	0.6	1.7	0.4	1.3	0.9	0.5	0.1
Medication: Cholesterol lowering	0.4	0.6	2.2	0.5	0.2	0.1	-0.7	-1.5
Trunk predicted mass	0.4	2.5	8.8	0.5	-3.0	-1.0	-1.2	-0.9
Standing height	0.4	4.4	9.0	1.1	-1.9	2.9	0.3	3.0
Exposure to tobacco smoke at home	0.4	0.4	1.3	-1.1	0.2	0.8	-0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.2	-1.5	-0.2	-0.1	0.2	0.2
High blood pressure (siblings)	0.4	0.6	1.4	1.2	0.6	-0.6	0.6	0.7
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	0.9	1.2	0.4	1.0	0.1
Heart disease (mother)	0.4	0.5	0.8	-0.5	-0.9	0.6	-0.8	-0.5
Comparative height size at age 10	0.4	2.0	4.4	-1.2	-2.1	1.6	-1.1	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	-0.2	-0.1	-0.9	-1.0	0.5
Loneliness, isolation	0.4	0.5	1.2	-0.3	-0.4	-0.8	-1.1	-0.6
Long-standing illness, disability or infirmity	0.4	0.7	1.8	-0.5	1.4	0.7	0.7	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.6	0.9	-0.3	1.0	0.4
Osteoporosis (self-reported)	0.4	0.5	1.4	0.8	0.8	0.3	0.0	1.2
Illnesses of father: None of the above (group 1)	0.4	0.4	1.5	-1.2	0.3	-0.0	0.5	-0.7
Mother’s age at death	0.4	0.5	1.1	-0.9	-0.6	-0.1	1.1	0.1
Irritability	0.4	0.6	1.9	-1.4	-0.0	1.0	0.1	-0.4
Unable to work because of sickness or disability	0.4	0.6	1.6	-0.4	0.7	1.2	0.0	-0.7
Myopia	0.4	0.5	1.7	0.4	-0.0	-1.3	0.3	-0.7
Cholesterol lowering medication	0.4	0.6	1.3	-0.3	-0.9	-1.1	-0.7	-0.6
Schizophrenia (2018)	0.3	0.6	1.1	-0.6	0.3	1.0	-1.0	0.6
Forced vital capacity (FVC)	0.3	1.0	2.5	-0.0	-1.6	-0.9	-1.4	-0.0
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.3	-0.5	0.5	0.6	-1.1
Heart attack	0.3	0.3	0.9	0.5	0.5	0.9	0.4	0.4
Medication: Simvastatin	0.3	0.5	1.0	0.1	-0.6	-0.5	-0.9	-1.0
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.3	-0.4	1.0	-0.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	-1.0	0.6	0.6	0.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.1	0.1	-1.5	-1.0	-0.8	0.5
Length of working week for main job	0.3	0.3	0.5	-0.4	-0.7	0.5	-0.6	-0.4
Loud music exposure frequency	0.3	0.4	0.9	0.6	0.5	0.6	-0.1	1.0
Medication: Allopurinol	0.3	0.4	0.6	0.8	0.8	0.5	0.3	0.6
Alcohol intake frequency.	0.3	0.7	1.7	-1.3	-0.2	1.1	-0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.3	0.6	1.1	0.4	-0.5
Medication: Aspirin	0.3	0.4	1.0	-0.4	-0.5	0.1	-0.7	-1.0
Medication: Aspirin	0.3	0.4	0.9	-0.3	-0.5	0.4	-1.0	-0.9
Miserableness	0.3	0.5	1.3	-0.6	1.1	0.0	0.5	0.9
Ever depressed for a whole week	0.3	0.3	0.5	-0.6	0.1	0.6	-0.6	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.6	0.6	0.9	0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.7	0.0	1.3	0.3	0.2	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	-0.6	0.0	-0.4	-0.8	0.8
Depression (Nagel 2018)	0.2	0.4	0.8	0.3	0.9	-0.1	0.8	0.5
Major Depression (MDD)	0.2	0.3	0.8	-0.9	-0.4	-0.1	-0.5	-0.4
HbA1C	0.2	0.2	0.4	-0.7	0.2	-0.5	0.4	-0.5
HDL Cholesterol	0.2	0.4	1.5	-1.2	-0.7	-0.1	-0.2	-0.2
Lupus	0.2	0.3	0.8	-0.1	0.8	-0.2	0.0	-0.9
Schizophrenia (2014)	0.2	0.4	1.5	-0.3	-0.0	0.4	-0.7	1.2
Cardiovascular Disease	0.2	0.7	1.6	0.7	-0.7	-0.8	-0.7	-1.3
Hand grip strength (left)	0.2	0.4	1.5	0.3	0.5	1.2	0.1	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	-0.9	0.2	0.2	0.1	-0.5
Supplements: Zinc	0.2	0.2	1.0	0.2	0.1	-1.0	0.0	0.0
Hand grip strength (right)	0.2	0.6	1.2	0.8	0.9	0.1	0.7	1.1
Taking other prescription medications	0.2	0.3	1.0	-1.0	0.0	-0.2	-0.6	-0.3
High blood pressure	0.2	0.7	2.2	-0.1	-0.4	-0.6	-0.8	-1.5
Sitting height	0.2	1.2	3.5	0.7	-1.9	0.6	-0.6	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.0	-0.1	1.4	-0.5	0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	0.8	-0.8	-0.2	-0.4	1.1
Blood clot in the leg (DVT)	0.2	0.3	1.2	0.1	1.1	0.2	0.3	0.3
Comparative body size at age 10	0.2	0.7	1.5	-1.0	-1.2	-0.7	-0.4	-0.4
Shortness of breath walking on level ground	0.2	0.3	0.9	-0.2	0.2	-0.3	-0.4	-0.9
Hypertension (Self-reported)	0.2	0.5	2.1	0.6	0.0	-0.3	-0.4	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	0.6	0.1	-0.1	-0.2	1.0
Hearing aid user	0.2	0.2	0.7	0.4	0.3	-0.1	0.1	0.9
Medication: Blood pressure	0.2	0.3	0.6	-0.3	0.5	-0.8	0.6	0.6
Medication: Lisinopril	0.2	0.3	0.7	-0.7	0.4	-0.4	-0.8	-0.3
Medication: Atorvastatin	0.2	0.2	0.5	0.7	0.2	-0.3	-0.2	-0.7
Age started oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.3	-0.4	-0.1	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.2	0.6	0.2	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-0.1	0.3	0.7	0.7	1.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.8	0.3	-0.3	-0.1	0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.1	-0.5	0.6	-0.1	0.0
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.8	-0.6	-0.1	-0.4	-0.2
Respiratory disease	0.1	0.2	0.7	0.3	0.1	-0.8	0.4	0.2
Hair Pigment	0.1	1.7	4.1	0.1	-0.8	0.3	-2.0	-1.9
Diabetes (father)	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.1	0.5	0.6	0.2	-0.1
Had other major operations	0.1	0.1	0.4	-0.0	0.7	-0.1	0.1	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	-0.0	0.0	-0.4	0.2	0.4
Birth weight	0.1	0.2	0.8	0.5	0.9	0.2	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.3	0.5	-0.1	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	-0.1	-0.1	-0.5	0.7	-0.1
Average weekly red wine intake	0.1	0.2	0.5	0.5	-0.2	-0.2	0.4	-0.7
Medication for cholesterol	0.1	0.2	1.0	0.3	-0.2	1.0	-0.1	-0.1
Medication: Gliclazide	0.1	0.1	0.3	0.2	-0.5	-0.3	0.3	0.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	-0.6	0.1	-0.3	-0.3	-0.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.5	0.3	-0.5	0.3	0.3
Heart disease (siblings)	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.2	0.1
Breast Cancer	0.0	0.1	0.1	0.4	0.3	0.2	0.3	-0.3
Alcohol usually taken with meals	0.0	0.0	0.1	-0.1	0.2	0.0	0.3	-0.0

Hub : Genes

MAPK1IP1L

Models

Trait associations