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chr15:66,662,107-69,178,312

Best TWAS P=4.74e-31 · Best GWAS P=1.51e-38 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	-7.901	-8.5	1.6e-17	-0.04	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IQCH	0.13	0.11	bslmm	597	0.10	5.9e-12	-9.300	7.2	8.8e-13	0.06	1.00	0.00	FALSE
3	GTEx	Adrenal Gland	IQCH-AS1	0.11	0.00	lasso	3	0.01	9.9e-02	4.204	5.6	2.6e-08	0.12	0.21	0.04	TRUE
4	GTEx	Artery Coronary	MAP2K5	0.11	0.00	enet	28	0.03	4.5e-02	-9.300	5.3	1.1e-07	-0.03	0.14	0.05	TRUE
5	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-9.161	7.4	1.7e-13	-0.02	0.49	0.03	FALSE
6	GTEx	Cells Transformed fibroblasts	SMAD3	0.12	0.01	lasso	9	0.06	3.6e-05	-2.474	-8.7	5.4e-18	-0.05	0.24	0.08	TRUE
7	GTEx	Esophagus Gastroesophageal Junction	PIAS1	0.26	0.00	enet	27	0.03	2.3e-02	2.102	5.4	8.5e-08	0.03	0.11	0.10	TRUE
8	GTEx	Ovary	SMAD3	0.32	0.02	enet	20	0.09	3.0e-03	-0.028	-5.1	2.7e-07	-0.25	0.10	0.07	FALSE
9	GTEx	Thyroid	SMAD3	0.19	0.02	enet	3	0.03	2.3e-03	12.984	-10.5	9.0e-26	-0.75	0.00	0.97	TRUE
10	YFS	Blood	PIAS1	0.08	0.04	lasso	7	0.06	1.3e-18	4.572	-5.2	1.6e-07	0.07	0.01	0.99	TRUE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-5.387	5.3	1.2e-07	0.00	0.06	0.93	TRUE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-9.153	6.7	2.1e-11	-0.01	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-5.257	7.6	2.4e-14	0.00	0.05	0.89	FALSE
14	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-5.257	5.8	5.6e-09	-0.08	0.12	0.77	FALSE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-4.145	6.8	7.3e-12	-0.09	0.03	0.94	FALSE
16	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-2.168	6.1	1.4e-09	-0.07	0.20	0.80	TRUE
17	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-5.387	6.0	2.6e-09	-0.06	0.05	0.90	FALSE
18	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CALML4	0.09	0.08	blup	27	0.08	4.3e-04	4.640	-5.1	3.1e-07	0.06	0.02	0.81	FALSE
19	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-5.387	5.3	1.2e-07	-0.05	0.03	0.66	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-5.331	5.6	2.0e-08	-0.05	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	SMAD3	0.22	0.12	enet	12	0.11	5.2e-11	12.050	-11.6	4.7e-31	-0.88	0.01	0.99	TRUE