Hub : Genes

AAGAB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.059 0.021 0.00008 0.045 0.045 0.054 0.05 0.045 3.0e-06 3.2e-06 3.2e-07 9e-07 3.3e-06
2 GTEx Esophagus Muscularis 0.082 0.038 0.00470 0.032 NA 0.015 NA 0.026 4.9e-03 NA 4.1e-02 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.9 3.0 4.0 -1.4 2.0
Bipolar Disorder or Schizophrenia 1.3 3.3 3.5 -1.9 1.7
Depressed Affect (Nagel 2018) 2.3 4.8 5.8 2.4 2.0
Depression (Nagel 2018) 2.7 4.1 6.8 2.6 1.2
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.7 -0.8 0.6
Neuroticism (Nagel 2018) 2.5 5.9 9.9 3.1 1.4
Schizophrenia (2018) 0.5 1.0 1.6 -1.3 0.6
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 0.2 -0.9
Worry (Nagel 2018) 4.5 9.5 15.4 3.9 1.9
Alzheimer’s Disease (in mother) 0.6 0.7 1.2 1.1 0.3
Alzheimer’s Disease (in father) 0.8 0.8 1.4 -1.2 -0.5
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 0.1 -0.2
Crohns Disease (2017) 1.7 3.6 5.1 -2.3 -1.5
Irritable Bowel Disease (IBD) 3.0 7.3 10.1 -3.2 -2.1
Ulcerative Colitis (UC) 2.4 4.5 6.8 -2.6 -1.5
Major Depression (MDD) 1.6 1.9 3.4 0.6 1.8
Reaction Time 0.0 0.1 0.2 -0.2 -0.4
Verbal and Numeric Reasoning (VNR) 0.6 1.6 3.1 0.0 1.8
Breast Cancer 0.7 1.7 2.7 1.6 -0.9
Ovarian Cancer 0.1 0.1 0.1 -0.4 -0.1
Prostate Cancer 1.1 1.5 1.8 1.4 1.1
Age at First Birth 2.5 3.7 7.1 -0.5 -2.7
Bipolar Disorder (2011) 4.5 4.3 5.6 1.7 2.4
Body Mass Index (BMI) (2010) 1.8 2.4 4.6 -2.1 -0.5
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.5 0.1
Crohns Disease (2012) 3.8 6.1 7.0 -2.6 -2.3
Mean Putamen Volume 0.4 0.4 0.5 0.7 0.5
Fasting Glucose 0.5 0.6 1.1 -0.2 -1.0
HbA1C 0.1 0.1 0.2 0.2 0.5
HDL Cholesterol 0.3 0.4 0.5 -0.6 -0.7
LDL Cholesterol 0.6 1.0 1.0 -1.0 -1.0
Lupus 0.1 0.2 0.4 0.2 -0.6
Neuroticism (2016) 1.6 2.3 3.4 1.8 1.1
Primary Biliary Cirrhosis 0.4 0.6 1.1 -1.1 0.0
Rheumatoid Arthritis 0.6 0.8 1.3 -0.7 1.1
Schizophrenia (2014) 0.4 0.9 1.4 -1.2 0.6
Triglycerides 0.0 0.1 0.1 0.4 -0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 -0.1 0.6
Ulcerative Colitis 1.9 2.8 4.5 -2.1 -1.1
Blood Eosinophil Count 6.1 47.2 72.6 -8.5 -4.7
Blood Platelet Count 0.2 2.6 4.8 -0.6 2.2
Blood Red Count 0.7 7.1 9.5 -3.1 -2.1
Blood White Count 0.3 2.2 3.9 -0.7 -2.0
Heel T-Score 2.5 20.2 39.4 6.3 0.9
BMI 1.7 9.7 19.4 -4.4 -0.1
Height 1.2 23.5 40.1 -6.3 -2.6
Waist Hip Ratio (WHR) 6.6 29.7 34.5 -5.9 -5.0
Systolic Blood Pressure 0.3 1.4 2.2 0.7 -1.5
Smoking Status 3.3 8.0 14.1 -3.8 -1.3
Allergy or Eczema 5.4 14.3 18.7 -4.3 -3.1
Cardiovascular Disease 3.4 11.4 18.7 -4.3 -2.0
Hypothyroidism (self reported) 0.4 0.9 1.0 1.0 -0.9
Respiratory disease 18.8 41.9 60.2 -7.8 -4.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.9 0.3 0.9
Lung FEV1/FVC ratio 2.4 12.4 13.5 3.7 3.4
Lung FVC 5.7 29.2 50.1 -7.1 -2.9
Neuroticism 5.8 14.0 23.8 4.9 2.1
Chronotype (morning person) 0.9 2.0 3.1 -1.8 -0.9
Hair Pigment 0.1 1.8 2.9 -0.9 -1.7
Tanning 0.0 0.2 0.3 0.0 -0.6
Hand grip strength (left) 0.7 1.8 3.1 0.7 1.8
Number of treatments/medications taken 2.8 5.0 7.4 -2.7 -1.6
Average weekly spirits intake 2.4 3.0 3.8 1.5 1.9
Sensitivity / hurt feelings 2.4 4.2 8.4 2.9 -0.0
Frequency of depressed mood in last 2 weeks 1.6 2.3 2.8 1.7 1.3
Hearing difficulty/problems: Yes 1.8 2.7 3.0 -1.7 1.6
Relative age of first facial hair 0.5 1.0 2.0 0.1 1.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.2 -1.5 0.6
Ever used hormone-replacement therapy (HRT) 0.9 1.2 1.8 0.7 1.3
Ever had hysterectomy (womb removed) 0.5 0.5 0.8 -0.5 -0.9
Systolic blood pressure, automated reading 0.4 1.2 2.2 0.5 -1.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 -0.8 -0.1
Angina 0.1 0.1 0.1 0.1 0.4
Medication for hormone replacement therapy 1.0 1.2 2.3 0.1 1.5
Vitamin and mineral supplements 2.1 2.8 4.4 -2.1 -1.1
Supplements: Zinc 4.4 4.8 7.0 2.6 1.6
Medication: Co-codamol 2.0 2.4 3.9 -0.9 -2.0
Medication: Metformin 0.7 1.0 1.5 -0.8 1.2
Diabetes (father) 0.7 0.9 1.5 -1.2 -0.5
Diabetes (mother) 0.8 1.0 1.6 1.3 0.6
Severe depression (siblings) 0.7 0.7 1.5 -1.2 0.1
Pack years adult smoking proportion 0.1 0.2 0.3 0.6 0.1
Impedance of leg (right) 1.8 8.8 14.6 -1.8 -3.8
Leg fat-free mass (left) 1.1 5.7 10.9 -3.3 0.7
Trunk fat percentage 9.5 37.9 60.4 -7.8 -3.9
Hand grip strength (right) 0.3 0.9 0.9 0.9 0.9
Townsend deprivation index at recruitment 1.8 2.6 5.0 -2.2 0.3
Current tobacco smoking 0.8 1.3 1.6 -1.0 -1.3
Average weekly fortified wine intake 0.6 0.7 1.2 1.1 0.3
Maternal smoking around birth 2.6 3.8 6.1 -2.5 -1.3
Fed-up feelings 0.5 0.8 1.7 1.3 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.6 1.3 1.0
Relative age voice broke 0.4 0.7 1.2 1.1 0.3
Taking other prescription medications 4.6 7.1 13.8 -3.7 -0.6
Age when periods started (menarche) 3.4 8.2 16.3 4.0 0.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.0 1.0 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.7 1.6 -0.2
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.4 0.2
Qualifications: CSEs or equivalent 1.1 1.4 1.6 -1.3 -1.1
Serious illness, injury or assault to yourself 0.9 1.1 1.8 -1.4 0.6
High blood pressure 3.6 10.1 17.1 -4.1 -1.7
Hayfever, allergic rhinitis or eczema 5.0 10.8 12.7 -3.6 -3.0
Multivitamins +/- minerals 1.8 2.2 3.8 1.9 0.8
Stomach or abdominal pain in last month 0.3 0.4 0.6 -0.8 0.5
Supplements: Glucosamine 0.1 0.2 0.3 0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 2.1 -1.2 1.5
Medication: Atenolol 1.7 2.1 3.3 -1.8 -1.0
Medication: Levothyroxine sodium 1.3 2.2 4.2 0.4 -2.1
Sitting height 0.9 6.5 10.6 -3.2 -1.6
Chronic bronchitis/emphysema (father) 4.0 4.6 9.3 -3.0 0.2
High blood pressure (mother) 0.3 0.5 0.6 -0.8 -0.5
Body mass index (BMI) 1.3 5.6 11.1 -3.3 -0.1
Impedance of leg (left) 1.7 8.3 14.1 -1.6 -3.8
Leg predicted mass (left) 1.1 5.8 11.0 -3.3 0.7
Trunk fat mass 7.6 32.8 56.7 -7.5 -3.0
Waist circumference 4.5 16.4 31.4 -5.6 -1.2
Number of incorrect matches in round 0.2 0.4 0.7 -0.2 0.8
Past tobacco smoking 4.9 9.0 17.4 4.2 0.8
Alcohol usually taken with meals 1.2 1.9 2.5 1.6 1.2
Nervous feelings 5.0 9.2 16.8 4.1 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.8 -0.9 -0.1
Hearing difficulty/problems with background noise 0.3 0.4 0.8 -0.1 0.9
Hair/balding pattern: Pattern 2 1.2 1.6 2.3 1.5 -0.9
Had menopause 0.2 0.3 0.5 0.1 0.7
Had other major operations 0.2 0.3 0.3 -0.6 -0.5
Forced vital capacity (FVC) 6.5 25.0 34.4 -5.9 -4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 3.1 1.8 -0.8
Ever unenthusiastic/disinterested for a whole week 1.9 2.4 2.8 -1.4 -1.7
Qualifications: None of the above 0.7 1.5 1.8 -1.1 -1.3
Financial difficulties in last 2 years 0.8 1.1 1.7 -1.3 -0.7
Mouth/teeth dental problems 0.3 0.4 0.8 0.9 0.0
Heart attack 1.6 2.1 3.6 -1.9 -0.7
Allergy 10.3 23.6 30.8 5.6 4.0
Pain all over the body in last month 2.8 3.0 4.4 1.3 2.1
Diabetes (self-reported) 0.2 0.2 0.5 -0.1 0.7
Hayfever/allergic rhinitis (self-reported) 2.8 3.7 3.8 -1.9 -2.0
Medication: Ramipril 7.2 9.3 15.1 -3.9 -1.8
Medication: Simvastatin 0.4 0.6 1.1 -1.0 -0.3
Fluid intelligence score 0.9 1.8 3.6 0.3 1.9
Illnesses of siblings 1.1 1.5 2.2 1.5 -0.9
Neuroticism score 3.3 6.9 12.7 3.6 1.0
Weight 2.7 13.2 26.0 -5.1 -0.6
Impedance of arm (right) 4.1 18.9 19.3 -4.3 -4.4
Arm fat percentage (right) 6.0 23.5 42.4 -6.5 -2.1
Trunk fat-free mass 0.7 4.2 6.9 -1.2 2.6
Hip circumference 1.7 7.4 13.4 -3.7 1.2
Time employed in main current job 1.2 1.4 1.8 -1.4 -1.0
Alcohol intake versus 10 years previously 0.5 0.8 0.9 -1.0 -0.8
Father’s age at death 1.8 2.4 4.7 0.1 2.2
Worrier / anxious feelings 1.7 3.1 5.3 2.3 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.1 -0.3 0.3
Falls in the last year 0.9 1.2 1.4 -1.0 1.2
Hair/balding pattern: Pattern 3 1.0 1.6 3.1 0.2 1.8
Number of live births 0.8 1.2 1.3 1.1 1.0
Forced expiratory volume in 1-second (FEV1) 2.8 9.5 14.3 -3.8 -2.2
Pulse rate 0.0 0.0 0.1 -0.3 0.2
Happiness 0.1 0.1 0.1 0.3 0.3
Noisy workplace 0.7 0.8 1.4 -1.2 -0.5
Qualifications: A levels/AS levels or equivalent 1.2 2.6 4.1 2.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 2.2 1.5 1.2
Mouth/teeth dental problems: Dentures 0.3 0.6 1.1 -1.0 -0.1
Asthma 12.6 24.8 36.6 -6.1 -3.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.5 -0.0
Medication: Cholesterol lowering 1.3 2.1 2.9 -1.7 -1.1
Depression (self-reported) 0.5 0.6 1.0 0.3 1.0
Medication: Lansoprazole 0.2 0.3 0.4 0.5 -0.6
Prospective memory result 0.1 0.1 0.1 0.2 -0.3
Lung cancer (father) 0.8 1.0 1.6 -1.3 0.6
Illnesses of mother 1.7 2.1 3.8 0.6 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 8.1 10.4 -3.2 -2.4
Pulse wave Arterial Stiffness index 1.7 2.0 3.9 -2.0 0.3
Impedance of arm (left) 4.2 19.3 21.9 -4.1 -4.7
Arm fat mass (right) 4.2 17.5 33.1 -5.8 -1.4
Trunk predicted mass 0.7 4.1 6.7 -1.3 2.6
Standing height 1.1 10.7 19.9 -4.5 -1.2
Length of working week for main job 0.4 0.5 0.8 -0.4 0.9
Exposure to tobacco smoke at home 0.7 0.8 1.6 -0.0 1.3
Breastfed as a baby 0.1 0.2 0.4 -0.6 -0.0
Tense / ‘highly strung’ 0.4 0.6 1.1 1.1 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.3 -1.1 -0.3
Hair/balding pattern: Pattern 4 3.0 7.3 14.6 3.8 -0.1
Birth weight of first child 1.5 2.7 5.0 -2.2 0.7
Peak expiratory flow (PEF) 0.1 0.1 0.1 0.4 -0.3
Pulse wave reflection index 1.0 1.3 1.6 -1.2 1.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.7 1.3 -0.1
Loud music exposure frequency 0.2 0.3 0.5 0.1 0.7
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 6.7 1.3 2.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.3 0.4 0.5
Blood clot in the leg (DVT) 0.0 0.0 0.1 -0.2 0.3
Medication: Paracetamol 0.3 0.5 0.9 0.9 -0.4
Headache pain in last month 1.6 2.7 4.6 2.1 -0.9
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 4.3 2.1 1.5
Glaucoma (self-reported) 0.6 0.7 0.9 0.7 -0.9
Gout (self-reported) 0.4 0.6 0.7 -0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 0.7 1.5 2.7 0.4 -1.7
Medication: Amlodipine 0.6 0.9 1.4 1.2 0.6
Medication: Ventolin 100micrograms inhaler 10.9 14.0 20.9 -4.6 -2.6
Birth weight 0.3 0.6 1.0 0.5 1.0
Chronic bronchitis/emphysema (mother) 5.7 6.6 12.4 -3.5 -0.9
High blood pressure (siblings) 1.3 1.8 3.5 -0.4 1.9
Forced vital capacity (FVC), Best measure 5.6 20.5 26.7 -5.2 -3.8
Body fat percentage 8.1 31.8 52.4 -7.2 -3.4
Leg fat percentage (right) 4.4 15.9 28.1 -5.3 -2.0
Arm fat-free mass (right) 0.5 2.4 2.5 -1.6 1.5
Exposure to tobacco smoke outside home 1.1 1.4 2.8 -0.3 -1.7
Comparative body size at age 10 2.3 6.3 12.6 -3.5 -0.1
Number of full brothers 0.5 0.6 1.2 -1.1 -0.2
Worry too long after embarrassment 4.5 7.5 13.5 3.7 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.4 -1.2 0.6
Wheeze or whistling in the chest in last year 6.2 11.1 15.8 -4.0 -2.5
Number of children fathered 0.2 0.3 0.5 0.7 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 -0.8 0.1
Age at first live birth 1.1 2.0 3.8 0.4 -1.9
Pulse wave peak to peak time 1.1 1.3 2.4 1.5 -0.4
Health satisfaction 0.3 0.4 0.7 -0.9 -0.1
Shortness of breath walking on level ground 1.7 2.0 2.2 -1.5 -1.3
Qualifications: College or University degree 0.1 0.4 0.5 0.5 0.7
Eye problems/disorders: None of the above 0.3 0.3 0.4 -0.5 0.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.8 -0.2 1.3
Emphysema/chronic bronchitis 5.0 5.6 6.9 -2.6 -2.1
Medication for pain relief, constipation, heartburn 0.2 0.4 0.6 0.3 0.8
Neck or shoulder pain in last month 1.9 2.7 3.0 1.5 1.7
Medication: Blood pressure 1.7 3.0 5.0 -2.2 -1.0
Angina (self-reported) 0.0 0.0 0.0 0.1 0.1
Migraine (self-reported) 0.1 0.1 0.3 -0.2 -0.5
Medication: Ibuprofen 0.8 1.0 1.2 1.1 0.9
Medication: Allopurinol 0.9 1.3 1.6 -1.3 -1.0
Medication: Omeprazole 0.8 1.0 1.8 -0.4 1.4
Medication: Seretide 50 evohaler 9.2 10.6 12.5 -3.5 -2.9
Mean time to correctly identify matches 0.1 0.2 0.2 0.4 0.5
Heart disease (mother) 0.7 0.9 1.3 -0.7 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.2 1.1 0.6
Whole body fat mass 6.2 25.8 46.5 -6.8 -2.3
Leg fat mass (right) 4.6 17.7 32.3 -5.7 -1.7
Arm predicted mass (right) 0.5 2.4 2.8 -1.4 1.7
Pulse rate, automated reading 0.5 1.7 3.4 -1.8 -0.1
Alcohol intake frequency. 0.9 2.1 2.5 1.6 1.3
Comparative height size at age 10 2.6 14.3 26.7 -5.2 -1.3
Number of full sisters 0.2 0.2 0.4 -0.6 -0.2
Suffer from ‘nerves’ 3.0 4.7 9.4 3.1 -0.1
Overall health rating 2.1 4.5 8.3 -2.9 -0.8
Chest pain or discomfort 1.1 1.7 2.0 -1.1 -1.4
Had major operations 1.8 2.1 3.4 -1.8 0.9
Age at last live birth 0.1 0.1 0.3 0.5 -0.0
Family relationship satisfaction 0.2 0.3 0.4 -0.7 0.3
Leg pain on walking 1.3 1.6 3.1 -0.2 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.3 0.8 -1.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.6 -0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 1.3 1.1 0.2
Medication: Aspirin 1.8 2.3 4.1 -0.7 -2.0
Supplements: Vitamin C 1.2 1.5 2.6 0.5 -1.6
Knee pain experienced in last month 0.4 0.7 1.0 -1.0 -0.6
Hypertension (Self-reported) 2.9 7.9 14.3 -3.8 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.5 0.0
Illnesses of father: Heart disease 0.9 1.2 2.4 0.2 -1.6
Illnesses of siblings: Diabetes 1.3 1.6 1.8 -1.2 1.3
Smoking status: Previous 2.9 4.3 8.5 -2.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.3 -1.5 -0.4
Whole body fat-free mass 0.7 4.0 4.2 -2.0 1.9
Leg fat-free mass (right) 0.8 4.4 7.5 -2.7 1.1
Arm fat percentage (left) 5.9 23.5 41.7 -6.5 -2.3
Average weekly red wine intake 0.9 1.3 2.7 -1.6 0.2
Handedness (chirality/laterality): Left-handed 1.6 2.0 3.6 1.9 0.5
Mood swings 0.8 1.5 2.1 0.9 1.4
Loneliness, isolation 0.7 1.0 1.8 -0.4 1.3
Long-standing illness, disability or infirmity 4.6 7.0 13.8 -3.7 0.3
Ever had bowel cancer screening 0.5 0.6 1.1 0.3 1.1
Diabetes diagnosed by doctor 0.1 0.1 0.1 -0.2 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 0.4 -1.2
Friendships satisfaction 0.1 0.1 0.1 0.2 0.3
Qualifications: nursing, teaching 0.5 0.8 1.4 1.2 0.4
Commuting to job workplace: Walk 0.2 0.2 0.3 0.3 0.5
Eye problems/disorders: Cataract 1.8 2.1 3.2 1.8 1.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.6 0.1
Medication for cholesterol 0.1 0.2 0.4 0.6 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.7 -0.7 1.3
Back pain experienced in last month 3.1 4.5 7.9 1.0 2.8
Mineral and other dietary supplements 1.8 2.4 3.6 -1.9 1.1
Breast cancer (self-reported) 1.0 1.2 2.1 0.6 1.4
Asthma (self-reported) 13.2 26.3 37.7 -6.1 -3.9
Osteoporosis (self-reported) 1.7 2.1 2.4 -1.6 -1.3
Osteoarthritis (self-reported) 1.3 1.7 2.7 -1.7 -0.8
Medication: Aspirin 2.8 3.7 6.2 -1.1 -2.5
Medication: Gliclazide 0.8 0.9 1.3 -1.1 0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 1.2 0.3
Smoking status: Current 1.4 2.1 2.5 -1.6 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 5.6 -2.4 -0.4
Whole body water mass 0.7 4.0 4.2 -2.1 1.9
Leg predicted mass (right) 0.8 4.4 7.4 -2.7 1.2
Arm fat mass (left) 4.5 18.4 34.9 -5.9 -1.4
Number of self-reported non-cancer illnesses 10.9 19.0 32.1 -5.7 -2.4
Average weekly champagne plus white wine intake 1.3 1.8 2.9 0.8 1.7
Miserableness 4.3 7.4 9.8 3.1 2.2
Guilty feelings 1.1 1.6 3.0 1.7 -0.4
Wears glasses or contact lenses 0.8 1.0 1.4 1.2 0.8
Ever taken oral contraceptive pill 0.4 0.4 0.8 -0.1 -0.9
Hearing aid user 1.5 1.7 3.2 0.3 1.8
Mother’s age at death 1.7 2.1 2.5 1.3 -1.6
Financial situation satisfaction 0.2 0.3 0.6 0.0 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 -0.5 -0.2
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.5 0.1
Eye problems/disorders: Glaucoma 1.2 1.5 2.5 1.6 -0.7
Medication: Blood pressure 1.1 2.2 2.7 -1.6 -1.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.6 0.2
Supplements: Fish oil (including cod liver oil) 1.6 2.0 3.8 2.0 -0.5
High cholesterol (Self-reported) 2.0 3.6 4.1 -2.0 -1.7
Medication: Bendroflumethiazide 0.9 1.4 2.7 -1.6 0.1
Medication: Paracetamol 0.1 0.2 0.3 0.3 -0.5
Medication: Lisinopril 0.3 0.4 0.5 0.6 -0.7
Medication: Atorvastatin 3.7 4.6 7.3 -1.4 -2.7
Illnesses of father: High blood pressure 1.3 1.6 1.8 1.2 1.3
Alcohol drinker status: Never 4.2 5.0 5.0 2.2 2.2
Ever smoked 2.7 4.8 9.3 -3.0 -0.5
Basal metabolic rate 0.9 5.0 8.5 -2.9 1.2
Leg fat percentage (left) 4.0 14.4 25.4 -5.0 -1.9
Arm fat-free mass (left) 0.6 3.3 3.4 -1.8 1.8
Number of operations (self-reported) 3.3 4.9 9.8 -3.1 -0.1
Average weekly beer plus cider intake 0.8 1.2 2.3 -0.3 -1.5
Irritability 0.6 1.1 1.4 -1.2 -0.9
Risk taking 1.1 1.7 1.9 -1.2 -1.4
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 -0.9 -0.4
Fractured/broken bones in last 5 years 7.5 9.6 18.5 -4.3 -0.9
Age started oral contraceptive pill 1.0 1.2 1.8 0.8 1.4
Diastolic blood pressure, automated reading 3.9 12.2 19.3 -4.4 -2.3
Ever depressed for a whole week 0.1 0.1 0.1 -0.3 0.3
Unable to work because of sickness or disability 2.2 2.9 5.6 0.3 2.4
Commuting to job workplace: Cycle 0.4 0.5 1.0 -1.0 0.2
Myopia 0.1 0.1 0.2 -0.4 -0.0
Vascular/heart problems diagnosed by doctor 3.9 10.6 18.3 4.3 1.7
Cholesterol lowering medication 0.8 1.2 1.7 -1.3 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.7 -0.7 1.3
Pain experienced in last month 0.8 1.4 1.9 -0.9 -1.4
Supplements: Calcium 1.1 1.3 1.5 -1.0 -1.2
Basal cell carcinoma (self-reported) 1.3 1.5 3.0 0.1 -1.7
Heart attack/myocardial infarction (self-reported) 1.6 2.0 3.5 -1.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.0 0.2
Heart disease (siblings) 1.8 2.2 2.6 1.4 1.6
Alcohol drinker status: Previous 0.1 0.1 0.2 0.1 0.5
Pack years of smoking 0.2 0.3 0.4 0.6 0.5
Impedance of whole body 3.5 17.7 23.5 -3.5 -4.8
Leg fat mass (left) 4.1 15.9 29.7 -5.4 -1.5
Arm predicted mass (left) 0.5 2.5 2.9 -1.5 1.7