TWAS hub - AAGAB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.059	0.021	0.00008	0.045	0.045	0.054	0.05	0.045	3.0e-06	3.2e-06	3.2e-07	9e-07	3.3e-06
2	GTEx	Esophagus Muscularis	0.082	0.038	0.00470	0.032	NA	0.015	NA	0.026	4.9e-03	NA	4.1e-02	NA	1.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Respiratory disease	18.8	41.9	60.2	-7.8	-4.8
Asthma (self-reported)	13.2	26.3	37.7	-6.1	-3.9
Asthma	12.6	24.8	36.6	-6.1	-3.6
Medication: Ventolin 100micrograms inhaler	10.9	14.0	20.9	-4.6	-2.6
Number of self-reported non-cancer illnesses	10.9	19.0	32.1	-5.7	-2.4
Allergy	10.3	23.6	30.8	5.6	4.0
Trunk fat percentage	9.5	37.9	60.4	-7.8	-3.9
Medication: Seretide 50 evohaler	9.2	10.6	12.5	-3.5	-2.9
Body fat percentage	8.1	31.8	52.4	-7.2	-3.4
Trunk fat mass	7.6	32.8	56.7	-7.5	-3.0
Fractured/broken bones in last 5 years	7.5	9.6	18.5	-4.3	-0.9
Medication: Ramipril	7.2	9.3	15.1	-3.9	-1.8
Waist Hip Ratio (WHR)	6.6	29.7	34.5	-5.9	-5.0
Forced vital capacity (FVC)	6.5	25.0	34.4	-5.9	-4.0
Wheeze or whistling in the chest in last year	6.2	11.1	15.8	-4.0	-2.5
Whole body fat mass	6.2	25.8	46.5	-6.8	-2.3
Blood Eosinophil Count	6.1	47.2	72.6	-8.5	-4.7
Arm fat percentage (right)	6.0	23.5	42.4	-6.5	-2.1
Arm fat percentage (left)	5.9	23.5	41.7	-6.5	-2.3
Neuroticism	5.8	14.0	23.8	4.9	2.1
Lung FVC	5.7	29.2	50.1	-7.1	-2.9
Chronic bronchitis/emphysema (mother)	5.7	6.6	12.4	-3.5	-0.9
Forced vital capacity (FVC), Best measure	5.6	20.5	26.7	-5.2	-3.8
Allergy or Eczema	5.4	14.3	18.7	-4.3	-3.1
Hayfever, allergic rhinitis or eczema	5.0	10.8	12.7	-3.6	-3.0
Nervous feelings	5.0	9.2	16.8	4.1	1.3
Emphysema/chronic bronchitis	5.0	5.6	6.9	-2.6	-2.1
Past tobacco smoking	4.9	9.0	17.4	4.2	0.8
Taking other prescription medications	4.6	7.1	13.8	-3.7	-0.6
Leg fat mass (right)	4.6	17.7	32.3	-5.7	-1.7
Long-standing illness, disability or infirmity	4.6	7.0	13.8	-3.7	0.3
Worry (Nagel 2018)	4.5	9.5	15.4	3.9	1.9
Bipolar Disorder (2011)	4.5	4.3	5.6	1.7	2.4
Waist circumference	4.5	16.4	31.4	-5.6	-1.2
Worry too long after embarrassment	4.5	7.5	13.5	3.7	1.2
Arm fat mass (left)	4.5	18.4	34.9	-5.9	-1.4
Supplements: Zinc	4.4	4.8	7.0	2.6	1.6
Leg fat percentage (right)	4.4	15.9	28.1	-5.3	-2.0
Miserableness	4.3	7.4	9.8	3.1	2.2
Impedance of arm (left)	4.2	19.3	21.9	-4.1	-4.7
Arm fat mass (right)	4.2	17.5	33.1	-5.8	-1.4
Alcohol drinker status: Never	4.2	5.0	5.0	2.2	2.2
Impedance of arm (right)	4.1	18.9	19.3	-4.3	-4.4
Leg fat mass (left)	4.1	15.9	29.7	-5.4	-1.5
Chronic bronchitis/emphysema (father)	4.0	4.6	9.3	-3.0	0.2
Leg fat percentage (left)	4.0	14.4	25.4	-5.0	-1.9
Diastolic blood pressure, automated reading	3.9	12.2	19.3	-4.4	-2.3
Vascular/heart problems diagnosed by doctor	3.9	10.6	18.3	4.3	1.7
Crohns Disease (2012)	3.8	6.1	7.0	-2.6	-2.3
Medication: Atorvastatin	3.7	4.6	7.3	-1.4	-2.7
High blood pressure	3.6	10.1	17.1	-4.1	-1.7
Impedance of whole body	3.5	17.7	23.5	-3.5	-4.8
Cardiovascular Disease	3.4	11.4	18.7	-4.3	-2.0
Age when periods started (menarche)	3.4	8.2	16.3	4.0	0.1
Smoking Status	3.3	8.0	14.1	-3.8	-1.3
Neuroticism score	3.3	6.9	12.7	3.6	1.0
Number of operations (self-reported)	3.3	4.9	9.8	-3.1	-0.1
Back pain experienced in last month	3.1	4.5	7.9	1.0	2.8
Irritable Bowel Disease (IBD)	3.0	7.3	10.1	-3.2	-2.1
Hair/balding pattern: Pattern 4	3.0	7.3	14.6	3.8	-0.1
Suffer from ‘nerves’	3.0	4.7	9.4	3.1	-0.1
Hypertension (Self-reported)	2.9	7.9	14.3	-3.8	-1.3
Smoking status: Previous	2.9	4.3	8.5	-2.9	0.2
Number of treatments/medications taken	2.8	5.0	7.4	-2.7	-1.6
Pain all over the body in last month	2.8	3.0	4.4	1.3	2.1
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	3.8	-1.9	-2.0
Forced expiratory volume in 1-second (FEV1)	2.8	9.5	14.3	-3.8	-2.2
Medication: Aspirin	2.8	3.7	6.2	-1.1	-2.5
Depression (Nagel 2018)	2.7	4.1	6.8	2.6	1.2
Weight	2.7	13.2	26.0	-5.1	-0.6
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	6.7	1.3	2.6
Ever smoked	2.7	4.8	9.3	-3.0	-0.5
Maternal smoking around birth	2.6	3.8	6.1	-2.5	-1.3
Comparative height size at age 10	2.6	14.3	26.7	-5.2	-1.3
Neuroticism (Nagel 2018)	2.5	5.9	9.9	3.1	1.4
Age at First Birth	2.5	3.7	7.1	-0.5	-2.7
Heel T-Score	2.5	20.2	39.4	6.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.1	10.4	-3.2	-2.4
Ulcerative Colitis (UC)	2.4	4.5	6.8	-2.6	-1.5
Lung FEV1/FVC ratio	2.4	12.4	13.5	3.7	3.4
Average weekly spirits intake	2.4	3.0	3.8	1.5	1.9
Sensitivity / hurt feelings	2.4	4.2	8.4	2.9	-0.0
Depressed Affect (Nagel 2018)	2.3	4.8	5.8	2.4	2.0
Comparative body size at age 10	2.3	6.3	12.6	-3.5	-0.1
Unable to work because of sickness or disability	2.2	2.9	5.6	0.3	2.4
Vitamin and mineral supplements	2.1	2.8	4.4	-2.1	-1.1
Overall health rating	2.1	4.5	8.3	-2.9	-0.8
Medication: Co-codamol	2.0	2.4	3.9	-0.9	-2.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	4.3	2.1	1.5
High cholesterol (Self-reported)	2.0	3.6	4.1	-2.0	-1.7
Bipolar Disorder (2018)	1.9	3.0	4.0	-1.4	2.0
Ulcerative Colitis	1.9	2.8	4.5	-2.1	-1.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.4	2.8	-1.4	-1.7
Neck or shoulder pain in last month	1.9	2.7	3.0	1.5	1.7
Body Mass Index (BMI) (2010)	1.8	2.4	4.6	-2.1	-0.5
Hearing difficulty/problems: Yes	1.8	2.7	3.0	-1.7	1.6
Impedance of leg (right)	1.8	8.8	14.6	-1.8	-3.8
Townsend deprivation index at recruitment	1.8	2.6	5.0	-2.2	0.3
Multivitamins +/- minerals	1.8	2.2	3.8	1.9	0.8
Father’s age at death	1.8	2.4	4.7	0.1	2.2
Had major operations	1.8	2.1	3.4	-1.8	0.9
Medication: Aspirin	1.8	2.3	4.1	-0.7	-2.0
Eye problems/disorders: Cataract	1.8	2.1	3.2	1.8	1.0
Mineral and other dietary supplements	1.8	2.4	3.6	-1.9	1.1
Heart disease (siblings)	1.8	2.2	2.6	1.4	1.6
Crohns Disease (2017)	1.7	3.6	5.1	-2.3	-1.5
BMI	1.7	9.7	19.4	-4.4	-0.1
Medication: Atenolol	1.7	2.1	3.3	-1.8	-1.0
Impedance of leg (left)	1.7	8.3	14.1	-1.6	-3.8
Hip circumference	1.7	7.4	13.4	-3.7	1.2
Worrier / anxious feelings	1.7	3.1	5.3	2.3	1.0
Illnesses of mother	1.7	2.1	3.8	0.6	1.9
Pulse wave Arterial Stiffness index	1.7	2.0	3.9	-2.0	0.3
Shortness of breath walking on level ground	1.7	2.0	2.2	-1.5	-1.3
Medication: Blood pressure	1.7	3.0	5.0	-2.2	-1.0
Osteoporosis (self-reported)	1.7	2.1	2.4	-1.6	-1.3
Mother’s age at death	1.7	2.1	2.5	1.3	-1.6
Major Depression (MDD)	1.6	1.9	3.4	0.6	1.8
Neuroticism (2016)	1.6	2.3	3.4	1.8	1.1
Frequency of depressed mood in last 2 weeks	1.6	2.3	2.8	1.7	1.3
Heart attack	1.6	2.1	3.6	-1.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	2.2	1.5	1.2
Headache pain in last month	1.6	2.7	4.6	2.1	-0.9
Handedness (chirality/laterality): Left-handed	1.6	2.0	3.6	1.9	0.5
Supplements: Fish oil (including cod liver oil)	1.6	2.0	3.8	2.0	-0.5
Heart attack/myocardial infarction (self-reported)	1.6	2.0	3.5	-1.9	-0.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.1	-1.2	1.5
Birth weight of first child	1.5	2.7	5.0	-2.2	0.7
Hearing aid user	1.5	1.7	3.2	0.3	1.8
Smoking status: Current	1.4	2.1	2.5	-1.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	5.6	-2.4	-0.4
Bipolar Disorder or Schizophrenia	1.3	3.3	3.5	-1.9	1.7
Medication: Levothyroxine sodium	1.3	2.2	4.2	0.4	-2.1
Body mass index (BMI)	1.3	5.6	11.1	-3.3	-0.1
Medication: Cholesterol lowering	1.3	2.1	2.9	-1.7	-1.1
High blood pressure (siblings)	1.3	1.8	3.5	-0.4	1.9
Leg pain on walking	1.3	1.6	3.1	-0.2	-1.8
Illnesses of siblings: Diabetes	1.3	1.6	1.8	-1.2	1.3
Osteoarthritis (self-reported)	1.3	1.7	2.7	-1.7	-0.8
Average weekly champagne plus white wine intake	1.3	1.8	2.9	0.8	1.7
Illnesses of father: High blood pressure	1.3	1.6	1.8	1.2	1.3
Basal cell carcinoma (self-reported)	1.3	1.5	3.0	0.1	-1.7
Height	1.2	23.5	40.1	-6.3	-2.6
Alcohol usually taken with meals	1.2	1.9	2.5	1.6	1.2
Hair/balding pattern: Pattern 2	1.2	1.6	2.3	1.5	-0.9
Time employed in main current job	1.2	1.4	1.8	-1.4	-1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.1	2.0	1.0
Supplements: Vitamin C	1.2	1.5	2.6	0.5	-1.6
Eye problems/disorders: Glaucoma	1.2	1.5	2.5	1.6	-0.7
Prostate Cancer	1.1	1.5	1.8	1.4	1.1
Leg fat-free mass (left)	1.1	5.7	10.9	-3.3	0.7
Qualifications: CSEs or equivalent	1.1	1.4	1.6	-1.3	-1.1
Leg predicted mass (left)	1.1	5.8	11.0	-3.3	0.7
Illnesses of siblings	1.1	1.5	2.2	1.5	-0.9
Standing height	1.1	10.7	19.9	-4.5	-1.2
Exposure to tobacco smoke outside home	1.1	1.4	2.8	-0.3	-1.7
Age at first live birth	1.1	2.0	3.8	0.4	-1.9
Pulse wave peak to peak time	1.1	1.3	2.4	1.5	-0.4
Chest pain or discomfort	1.1	1.7	2.0	-1.1	-1.4
Guilty feelings	1.1	1.6	3.0	1.7	-0.4
Medication: Blood pressure	1.1	2.2	2.7	-1.6	-1.3
Risk taking	1.1	1.7	1.9	-1.2	-1.4
Supplements: Calcium	1.1	1.3	1.5	-1.0	-1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.2	-1.5	0.6
Medication for hormone replacement therapy	1.0	1.2	2.3	0.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.6	1.3	1.0
Hair/balding pattern: Pattern 3	1.0	1.6	3.1	0.2	1.8
Pulse wave reflection index	1.0	1.3	1.6	-1.2	1.0
Breast cancer (self-reported)	1.0	1.2	2.1	0.6	1.4
Age started oral contraceptive pill	1.0	1.2	1.8	0.8	1.4
Chronotype (morning person)	0.9	2.0	3.1	-1.8	-0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.8	0.7	1.3
Serious illness, injury or assault to yourself	0.9	1.1	1.8	-1.4	0.6
Sitting height	0.9	6.5	10.6	-3.2	-1.6
Fluid intelligence score	0.9	1.8	3.6	0.3	1.9
Falls in the last year	0.9	1.2	1.4	-1.0	1.2
Medication: Allopurinol	0.9	1.3	1.6	-1.3	-1.0
Alcohol intake frequency.	0.9	2.1	2.5	1.6	1.3
Illnesses of father: Heart disease	0.9	1.2	2.4	0.2	-1.6
Average weekly red wine intake	0.9	1.3	2.7	-1.6	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	-0.7	1.3
Medication: Bendroflumethiazide	0.9	1.4	2.7	-1.6	0.1
Basal metabolic rate	0.9	5.0	8.5	-2.9	1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.7	-0.7	1.3
Alzheimer’s Disease (in father)	0.8	0.8	1.4	-1.2	-0.5
Diabetes (mother)	0.8	1.0	1.6	1.3	0.6
Current tobacco smoking	0.8	1.3	1.6	-1.0	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.1	1.8	-0.8
Financial difficulties in last 2 years	0.8	1.1	1.7	-1.3	-0.7
Number of live births	0.8	1.2	1.3	1.1	1.0
Lung cancer (father)	0.8	1.0	1.6	-1.3	0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-0.2	1.3
Medication: Ibuprofen	0.8	1.0	1.2	1.1	0.9
Medication: Omeprazole	0.8	1.0	1.8	-0.4	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.3	0.8	-1.1
Leg fat-free mass (right)	0.8	4.4	7.5	-2.7	1.1
Mood swings	0.8	1.5	2.1	0.9	1.4
Medication: Gliclazide	0.8	0.9	1.3	-1.1	0.7
Leg predicted mass (right)	0.8	4.4	7.4	-2.7	1.2
Wears glasses or contact lenses	0.8	1.0	1.4	1.2	0.8
Average weekly beer plus cider intake	0.8	1.2	2.3	-0.3	-1.5
Cholesterol lowering medication	0.8	1.2	1.7	-1.3	-0.9
Pain experienced in last month	0.8	1.4	1.9	-0.9	-1.4
Breast Cancer	0.7	1.7	2.7	1.6	-0.9
Blood Red Count	0.7	7.1	9.5	-3.1	-2.1
Hand grip strength (left)	0.7	1.8	3.1	0.7	1.8
Medication: Metformin	0.7	1.0	1.5	-0.8	1.2
Diabetes (father)	0.7	0.9	1.5	-1.2	-0.5
Severe depression (siblings)	0.7	0.7	1.5	-1.2	0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.0	1.0	0.8
Qualifications: None of the above	0.7	1.5	1.8	-1.1	-1.3
Trunk fat-free mass	0.7	4.2	6.9	-1.2	2.6
Noisy workplace	0.7	0.8	1.4	-1.2	-0.5
Trunk predicted mass	0.7	4.1	6.7	-1.3	2.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	-0.0	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.7	1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	2.7	0.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.4	-1.2	0.6
Heart disease (mother)	0.7	0.9	1.3	-0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	1.1	0.6
Whole body fat-free mass	0.7	4.0	4.2	-2.0	1.9
Loneliness, isolation	0.7	1.0	1.8	-0.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.4	0.4	-1.2
Whole body water mass	0.7	4.0	4.2	-2.1	1.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	1.1	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.6	3.1	0.0	1.8
LDL Cholesterol	0.6	1.0	1.0	-1.0	-1.0
Rheumatoid Arthritis	0.6	0.8	1.3	-0.7	1.1
Average weekly fortified wine intake	0.6	0.7	1.2	1.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.7	1.6	-0.2
Glaucoma (self-reported)	0.6	0.7	0.9	0.7	-0.9
Medication: Amlodipine	0.6	0.9	1.4	1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.3	-1.5	-0.4
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	1.2	0.3
Arm fat-free mass (left)	0.6	3.3	3.4	-1.8	1.8
Irritability	0.6	1.1	1.4	-1.2	-0.9
Schizophrenia (2018)	0.5	1.0	1.6	-1.3	0.6
Fasting Glucose	0.5	0.6	1.1	-0.2	-1.0
Relative age of first facial hair	0.5	1.0	2.0	0.1	1.4
Ever had hysterectomy (womb removed)	0.5	0.5	0.8	-0.5	-0.9
Fed-up feelings	0.5	0.8	1.7	1.3	-0.1
Alcohol intake versus 10 years previously	0.5	0.8	0.9	-1.0	-0.8
Depression (self-reported)	0.5	0.6	1.0	0.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.1	-0.3
Arm fat-free mass (right)	0.5	2.4	2.5	-1.6	1.5
Number of full brothers	0.5	0.6	1.2	-1.1	-0.2
Arm predicted mass (right)	0.5	2.4	2.8	-1.4	1.7
Pulse rate, automated reading	0.5	1.7	3.4	-1.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.3	1.1	0.2
Ever had bowel cancer screening	0.5	0.6	1.1	0.3	1.1
Qualifications: nursing, teaching	0.5	0.8	1.4	1.2	0.4
Arm predicted mass (left)	0.5	2.5	2.9	-1.5	1.7
Mean Putamen Volume	0.4	0.4	0.5	0.7	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.1	-1.1	0.0
Schizophrenia (2014)	0.4	0.9	1.4	-1.2	0.6
Hypothyroidism (self reported)	0.4	0.9	1.0	1.0	-0.9
Systolic blood pressure, automated reading	0.4	1.2	2.2	0.5	-1.5
Relative age voice broke	0.4	0.7	1.2	1.1	0.3
Medication: Simvastatin	0.4	0.6	1.1	-1.0	-0.3
Length of working week for main job	0.4	0.5	0.8	-0.4	0.9
Tense / ‘highly strung’	0.4	0.6	1.1	1.1	0.3
Gout (self-reported)	0.4	0.6	0.7	-0.7	-0.8
Knee pain experienced in last month	0.4	0.7	1.0	-1.0	-0.6
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.1	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.9	-0.4
Commuting to job workplace: Cycle	0.4	0.5	1.0	-1.0	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.2	-0.9
HDL Cholesterol	0.3	0.4	0.5	-0.6	-0.7
Blood White Count	0.3	2.2	3.9	-0.7	-2.0
Systolic Blood Pressure	0.3	1.4	2.2	0.7	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	0.3	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.8	-0.1
Hand grip strength (right)	0.3	0.9	0.9	0.9	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.8	0.5
High blood pressure (mother)	0.3	0.5	0.6	-0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	-0.9	-0.1
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.1	0.9
Mouth/teeth dental problems	0.3	0.4	0.8	0.9	0.0
Mouth/teeth dental problems: Dentures	0.3	0.6	1.1	-1.0	-0.1
Medication: Paracetamol	0.3	0.5	0.9	0.9	-0.4
Birth weight	0.3	0.6	1.0	0.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.8	0.1
Health satisfaction	0.3	0.4	0.7	-0.9	-0.1
Eye problems/disorders: None of the above	0.3	0.3	0.4	-0.5	0.6
Medication: Lisinopril	0.3	0.4	0.5	0.6	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.7	-0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.1	0.6
Blood Platelet Count	0.2	2.6	4.8	-0.6	2.2
Number of incorrect matches in round	0.2	0.4	0.7	-0.2	0.8
Had menopause	0.2	0.3	0.5	0.1	0.7
Had other major operations	0.2	0.3	0.3	-0.6	-0.5
Diabetes (self-reported)	0.2	0.2	0.5	-0.1	0.7
Medication: Lansoprazole	0.2	0.3	0.4	0.5	-0.6
Loud music exposure frequency	0.2	0.3	0.5	0.1	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	0.4	0.5
Number of children fathered	0.2	0.3	0.5	0.7	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.3	0.8
Number of full sisters	0.2	0.2	0.4	-0.6	-0.2
Family relationship satisfaction	0.2	0.3	0.4	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.3	0.3	0.5
Financial situation satisfaction	0.2	0.3	0.6	0.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	-0.6	0.2
Pack years of smoking	0.2	0.3	0.4	0.6	0.5
Ovarian Cancer	0.1	0.1	0.1	-0.4	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.5	0.1
HbA1C	0.1	0.1	0.2	0.2	0.5
Lupus	0.1	0.2	0.4	0.2	-0.6
Hair Pigment	0.1	1.8	2.9	-0.9	-1.7
Angina	0.1	0.1	0.1	0.1	0.4
Pack years adult smoking proportion	0.1	0.2	0.3	0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	0.2
Supplements: Glucosamine	0.1	0.2	0.3	0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.1	-0.3	0.3
Happiness	0.1	0.1	0.1	0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	-0.0
Prospective memory result	0.1	0.1	0.1	0.2	-0.3
Breastfed as a baby	0.1	0.2	0.4	-0.6	-0.0
Peak expiratory flow (PEF)	0.1	0.1	0.1	0.4	-0.3
Qualifications: College or University degree	0.1	0.4	0.5	0.5	0.7
Migraine (self-reported)	0.1	0.1	0.3	-0.2	-0.5
Mean time to correctly identify matches	0.1	0.2	0.2	0.4	0.5
Age at last live birth	0.1	0.1	0.3	0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	0.0
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.2	0.4
Friendships satisfaction	0.1	0.1	0.1	0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.6	0.1
Medication for cholesterol	0.1	0.2	0.4	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	-0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.5	0.1
Medication: Paracetamol	0.1	0.2	0.3	0.3	-0.5
Ever depressed for a whole week	0.1	0.1	0.1	-0.3	0.3
Myopia	0.1	0.1	0.2	-0.4	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.5
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	-0.2
Reaction Time	0.0	0.1	0.2	-0.2	-0.4
Triglycerides	0.0	0.1	0.1	0.4	-0.1
Tanning	0.0	0.2	0.3	0.0	-0.6
Pulse rate	0.0	0.0	0.1	-0.3	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.2	0.3
Angina (self-reported)	0.0	0.0	0.0	0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.0	0.2

Hub : Genes

AAGAB

Models

Trait associations