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chr19:260,912-1,966,232

Best TWAS P=8.19e-27 · Best GWAS P=7.51e-23 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GPX4	0.16	0.10	bslmm	447	0.11	6.7e-13	-9.84	-10.2	1.9e-24	0.85	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PALM	0.08	0.00	blup	481	0.02	1.6e-03	-9.84	-5.7	9.3e-09	0.29	0.01	0.81	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2E	0.23	0.14	bslmm	451	0.17	5.2e-20	-5.91	-7.4	1.2e-13	-0.05	1.00	0.00	FALSE
4	GTEx	Brain Cerebellum	HMHA1	0.45	0.07	lasso	8	0.04	1.9e-02	-5.86	-5.2	1.7e-07	-0.14	0.05	0.09	FALSE
5	GTEx	Cells Transformed fibroblasts	POLR2E	0.20	0.09	lasso	5	0.16	2.7e-12	5.34	6.8	9.3e-12	-0.47	0.99	0.01	TRUE
6	GTEx	Cells Transformed fibroblasts	GPX4	0.37	0.20	lasso	9	0.23	4.3e-17	-9.84	-9.6	1.1e-21	0.94	0.00	1.00	FALSE
7	GTEx	Nerve Tibial	GPX4	0.25	0.00	enet	14	0.05	3.1e-04	-8.41	-8.5	2.7e-17	0.63	0.01	0.91	FALSE
8	GTEx	Pituitary	CNN2	0.78	0.02	lasso	20	0.03	6.3e-02	7.65	5.7	1.6e-08	-0.14	0.04	0.05	TRUE
9	GTEx	Prostate	GPX4	0.41	0.23	lasso	3	0.22	4.1e-06	-9.84	-6.0	2.6e-09	0.94	0.00	0.98	FALSE
10	GTEx	Testis	HMHA1	0.26	0.15	lasso	2	0.14	1.1e-06	-5.86	5.9	4.3e-09	0.18	0.91	0.02	FALSE
11	GTEx	Thyroid	POLR2E	0.22	0.16	lasso	1	0.15	2.4e-11	5.34	5.3	9.4e-08	-0.20	1.00	0.00	TRUE
12	GTEx	Thyroid	GPX4	0.16	0.01	enet	12	0.02	1.7e-02	-6.26	-6.7	2.8e-11	0.70	0.01	0.93	FALSE
13	GTEx	Uterus	CIRBP-AS1	0.49	0.00	lasso	6	-0.01	6.3e-01	6.70	5.6	1.8e-08	-0.31	0.04	0.11	FALSE
14	NTR	Blood	CNN2	0.04	0.04	lasso	3	0.03	3.0e-11	6.85	-7.3	2.9e-13	-0.08	1.00	0.00	TRUE
15	NTR	Blood	GPX4	0.03	0.02	enet	7	0.03	2.3e-09	-8.41	-7.9	2.3e-15	0.53	0.80	0.20	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	POLR2E	0.29	0.27	lasso	4	0.29	6.6e-38	-6.15	-6.5	1.2e-10	-0.17	1.00	0.00	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	GPX4	0.17	0.08	enet	11	0.10	2.2e-13	-8.41	-8.6	8.8e-18	0.74	0.22	0.78	FALSE
18	YFS	Blood	ABCA7	0.20	0.04	bslmm	340	0.14	6.3e-44	1.16	-5.1	3.0e-07	0.22	1.00	0.00	FALSE
19	YFS	Blood	GPX4	0.34	0.33	enet	23	0.42	1.3e-150	-8.41	-10.7	8.2e-27	0.73	1.00	0.00	TRUE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GPX4	0.08	0.01	lasso	7	0.02	4.7e-03	-4.11	-5.2	1.9e-07	0.67	0.02	0.81	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SBNO2	0.08	0.00	blup	63	0.02	1.4e-02	0.68	-5.3	1.4e-07	0.19	0.04	0.03	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GPX4	0.06	0.02	enet	8	0.06	5.8e-07	-3.72	-7.6	2.3e-14	0.62	0.09	0.74	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPX4	0.12	0.11	lasso	4	0.12	3.9e-13	-9.84	-9.3	1.4e-20	0.98	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMHA1	0.06	0.06	lasso	2	0.05	3.1e-06	-5.42	-5.5	3.8e-08	-0.13	0.87	0.02	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPX4	0.04	0.05	lasso	4	0.05	1.6e-06	-8.41	-9.6	6.8e-22	0.74	0.04	0.96	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GPX4	0.07	0.04	blup	45	0.04	6.4e-05	-9.84	-10.1	4.1e-24	0.79	0.00	1.00	TRUE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABCA7	0.09	0.03	lasso	7	0.03	4.5e-04	-5.91	-5.2	2.5e-07	-0.17	0.43	0.05	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPX4	0.21	0.15	lasso	4	0.14	6.9e-15	-9.84	-9.8	8.4e-23	1.00	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	ABCA7	0.10	0.06	lasso	2	0.05	8.1e-06	-6.15	-5.4	8.2e-08	-0.17	0.72	0.01	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	GPX4	0.10	0.00	blup	45	0.03	2.9e-04	0.85	-8.1	7.1e-16	0.20	0.02	0.08	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	POLR2E	0.14	0.08	lasso	8	0.10	7.3e-10	1.80	5.6	1.9e-08	-0.59	0.07	0.93	FALSE