TWAS hub - HSF2BP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3010	0.0750	1.7e-06	0.270	NA	0.295	NA	0.305	2.2e-09	NA	3.2e-10	NA	1.4e-10
2	GTEx	Liver	0.2090	0.0850	4.8e-03	0.224	NA	0.150	NA	0.165	6.6e-07	NA	5.8e-05	NA	2.3e-05
3	GTEx	Muscle Skeletal	0.0969	0.0312	1.2e-05	0.040	NA	0.036	NA	0.037	8.2e-05	NA	1.7e-04	NA	1.5e-04
4	GTEx	Testis	0.2180	0.0550	2.1e-07	0.266	NA	0.256	NA	0.268	3.5e-12	NA	9.7e-12	NA	2.8e-12
5	TCGA	Pheochromocytoma and Paraganglioma	0.1590	0.0890	6.6e-03	-0.006	0.021	0.000	NA	-0.006	7.0e-01	0.047	3.3e-01	NA	7.1e-01
6	TCGA	Thyroid Carcinoma	0.0440	0.0270	5.0e-04	0.018	0.012	0.009	NA	0.015	7.0e-03	0.021	3.8e-02	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Blood pressure	14.0	24.7	35.7	-5.2	-0.4	-5.0	-5.4	5.6	-6.0
Medication for cholesterol, blood pressure or diabetes	11.8	19.6	28.1	4.5	1.0	4.6	4.9	-4.8	5.3
Hayfever/allergic rhinitis (self-reported)	9.9	13.2	19.2	4.0	2.4	3.9	4.1	-2.5	4.4
Vascular/heart problems diagnosed by doctor	8.2	22.2	31.2	4.8	-0.8	5.4	5.1	-5.6	4.8
Had major operations	8.0	9.3	12.9	-3.4	1.0	-3.6	-3.2	2.9	-3.4
High blood pressure	7.1	19.8	28.4	-4.7	0.8	-5.0	-4.6	5.3	-4.6
Hayfever, allergic rhinitis or eczema	7.1	15.4	19.9	4.5	3.8	4.3	3.9	-2.7	4.2
Coronary Artery Disease (CAD)	6.9	8.3	13.5	-3.4	-1.1	-3.7	-3.1	2.6	-2.6
Hypertension (Self-reported)	6.7	18.7	26.5	-4.6	0.7	-4.9	-4.5	5.1	-4.5
Medication: Blood pressure	6.6	12.5	17.3	-3.6	-0.2	-4.1	-4.0	4.2	-3.4
High blood pressure (siblings)	6.5	9.4	13.9	-3.2	-0.6	-3.6	-3.2	3.0	-3.7
Friendships satisfaction	6.2	7.7	11.2	2.8	1.6	3.0	3.0	-2.5	3.4
Systolic Blood Pressure	5.9	29.3	39.4	-5.5	0.2	-6.1	-5.9	5.8	-6.3
Cardiovascular Disease	5.9	19.6	27.2	-4.4	-0.4	-4.9	-5.0	5.2	-4.7
Breast cancer (self-reported)	5.7	6.8	10.3	3.2	1.2	2.8	2.7	-2.8	2.6
Alcohol intake versus 10 years previously	5.6	8.3	12.9	-3.2	-1.3	-3.6	-3.2	2.6	-2.8
Allergy or Eczema	5.3	14.0	17.6	4.2	3.1	4.1	3.8	-3.2	3.9
Mouth/teeth dental problems: Dentures	5.3	8.9	13.2	-3.1	-0.2	-3.6	-3.2	2.7	-3.6
Medication: Cholesterol lowering	5.3	8.2	12.3	-2.7	-1.0	-3.2	-2.9	3.5	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	5.3	6.1	10.9	-2.5	0.3	-3.1	-2.2	3.3	-2.3
Medication: Lisinopril	5.3	6.9	10.5	-2.4	-0.7	-2.7	-3.1	3.2	-2.7
Medication: Ramipril	4.7	6.0	10.7	-2.0	-0.4	-2.8	-2.6	3.3	-2.7
Medication: Atenolol	4.5	5.6	7.2	-2.6	-1.1	-2.7	-2.6	2.4	-2.5
Breast Cancer	4.4	10.6	15.2	-3.7	0.4	-3.2	-3.9	3.2	-3.7
Allergy	4.3	9.8	11.8	-3.4	-3.3	-3.4	-3.1	2.1	-3.3
Illnesses of mother	4.2	5.2	7.3	2.7	0.9	1.8	2.6	-2.4	2.6
Body Mass Index (BMI) (2010)	4.0	5.6	7.5	-2.7	-1.0	-2.3	-2.5	2.7	-2.5
Happiness	3.8	4.7	9.2	2.4	0.8	3.0	2.0	-2.0	2.1
Medication: Aspirin	3.7	4.8	7.6	-1.9	0.5	-2.8	-2.3	2.6	-2.3
Illnesses of siblings	3.6	5.0	7.3	2.6	-0.1	2.6	2.3	-2.0	2.7
Qualifications: A levels/AS levels or equivalent	3.3	7.4	12.8	3.5	-1.0	3.6	2.1	-3.1	2.0
Medication: Amlodipine	3.3	4.7	6.9	-2.4	1.4	-2.6	-1.8	2.3	-2.2
Angina (self-reported)	3.3	4.3	6.0	-1.5	-1.9	-2.0	-2.4	2.4	-2.1
Medication for cholesterol	3.3	5.1	7.6	2.5	0.5	2.7	2.8	-2.1	2.2
Crohns Disease (2012)	3.2	5.1	7.7	-2.2	-1.0	-2.8	-2.5	2.2	-2.4
Smoking Status	3.2	7.7	12.2	-3.1	-1.6	-3.5	-2.9	2.6	-2.6
Angina	3.1	4.0	5.8	-1.6	-1.8	-2.0	-2.2	2.4	-2.0
Past tobacco smoking	3.1	5.7	8.3	2.5	0.4	2.8	2.7	-2.9	2.1
Smoking status: Previous	3.0	4.4	6.8	-2.4	0.2	-2.5	-2.3	2.6	-1.5
Relative age voice broke	2.9	4.4	7.4	2.7	-0.4	2.1	2.1	-2.0	2.4
Medication: Simvastatin	2.9	4.3	7.1	-1.8	-0.4	-2.7	-2.1	2.2	-2.4
Time employed in main current job	2.9	3.3	6.7	-1.8	0.5	-1.7	-2.1	2.6	-1.6
Mother’s age at death	2.9	3.7	5.4	1.8	-0.0	1.8	2.2	-2.3	2.3
Heart attack	2.7	3.4	6.0	-1.4	0.3	-1.9	-2.1	2.4	-2.1
Mean time to correctly identify matches	2.7	5.1	7.6	2.2	0.9	2.1	2.8	-2.5	2.6
Medication: Bendroflumethiazide	2.7	4.1	6.3	-2.5	1.0	-2.4	-2.3	1.4	-2.0
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	6.3	-1.7	-0.7	-1.9	-2.5	1.5	-2.3
Reaction Time	2.6	5.0	7.1	2.3	0.4	2.5	2.7	-2.4	2.4
Medication: Aspirin	2.6	3.5	6.2	-1.6	0.1	-2.5	-1.9	2.3	-1.8
Supplements: Calcium	2.6	2.9	6.8	2.1	0.3	1.8	2.6	-0.6	1.5
Qualifications: CSEs or equivalent	2.5	3.3	6.9	1.2	-0.6	2.3	1.7	-2.6	1.6
Number of children fathered	2.5	2.8	4.3	-2.1	-1.4	-2.1	-1.8	1.0	-1.4
Ever had prostate specific antigen (PSA) test	2.5	2.9	5.0	-1.8	-0.1	-1.5	-1.9	2.2	-1.9
Bipolar Disorder or Schizophrenia	2.4	5.9	7.0	2.6	-1.8	2.5	2.6	-2.2	2.6
Blood Eosinophil Count	2.4	18.2	29.2	-4.8	-1.9	-4.8	-4.0	5.4	-3.7
Medication: Metformin	2.4	3.3	4.4	-1.8	0.6	-2.0	-2.0	2.1	-2.0
Family relationship satisfaction	2.3	2.9	5.4	2.0	0.8	2.3	1.7	-0.9	1.9
LDL Cholesterol	2.2	3.5	7.0	1.8	1.2	1.5	2.2	-1.4	2.6
Blood Red Count	2.2	21.2	30.2	-4.9	-1.1	-5.5	-4.9	4.6	-5.1
Diabetes (self-reported)	2.2	3.3	6.8	-2.1	-0.9	-2.6	-1.3	2.1	-1.5
Illnesses of father: High blood pressure	2.2	2.7	6.5	-1.7	-0.8	-1.5	-1.1	2.6	-1.6
Basal cell carcinoma (self-reported)	2.2	2.6	4.1	1.5	-0.4	1.7	1.7	-1.8	2.0
Bipolar Disorder (2018)	2.1	3.3	5.2	1.7	-1.5	2.0	2.3	-0.6	2.2
Number of full brothers	2.1	2.7	4.4	1.7	0.8	2.1	1.3	-1.6	2.0
Ever smoked	2.1	3.7	5.8	-1.9	-1.0	-2.0	-2.1	2.4	-1.8
Medication for hormone replacement therapy	2.0	2.2	3.2	-1.7	-1.5	-1.8	-1.6	0.8	-1.3
Comparative body size at age 10	2.0	5.4	8.6	-2.9	0.2	-2.6	-2.4	2.6	-2.2
Medication: Allopurinol	2.0	2.6	4.1	-1.8	-0.9	-2.0	-1.9	1.1	-1.6
Shortness of breath walking on level ground	1.9	2.2	3.9	-1.8	-0.2	-0.9	-1.4	2.0	-1.8
Heart disease (mother)	1.9	2.3	3.6	-1.9	-0.2	-1.0	-1.6	1.8	-1.9
Medication: Gliclazide	1.9	2.2	4.7	-1.9	-0.4	-1.6	-1.1	2.2	-1.1
Crohns Disease (2017)	1.8	3.9	7.5	-1.6	-1.2	-2.7	-2.1	2.2	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	4.2	-1.8	-1.1	-1.5	-2.1	1.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	3.7	-1.3	1.8	-1.3	-1.6	1.9	-1.2
Heart attack/myocardial infarction (self-reported)	1.8	2.4	4.2	-1.0	0.2	-1.6	-1.8	2.0	-1.8
Systolic blood pressure, automated reading	1.7	4.8	6.7	-2.0	0.4	-2.5	-2.5	2.4	-2.6
Eye problems/disorders: None of the above	1.7	1.9	4.1	1.4	-2.0	1.0	1.4	-0.6	1.5
Commuting to job workplace: Walk	1.7	1.8	2.3	1.5	0.8	1.5	1.4	-1.4	1.3
Asthma (self-reported)	1.7	3.4	4.6	1.9	1.2	2.1	2.2	-1.4	2.0
Smoking status: Current	1.7	2.7	3.9	-1.5	-1.2	-2.0	-1.7	1.4	-2.0
HbA1C	1.6	1.7	2.5	1.2	0.9	1.5	1.6	-1.2	1.4
Respiratory disease	1.6	3.6	5.0	2.2	1.4	2.2	2.1	-1.6	1.7
Current tobacco smoking	1.6	2.6	3.5	-1.4	-1.6	-1.9	-1.7	1.2	-1.9
Asthma	1.6	3.2	4.4	1.8	1.3	2.0	2.1	-1.5	2.0
Blood clot in the leg (DVT)	1.6	2.1	4.0	-1.3	-0.1	-1.4	-2.0	1.1	-1.9
Migraine (self-reported)	1.6	2.0	3.2	1.5	1.5	1.3	1.8	-0.0	1.6
Schizophrenia (2018)	1.5	3.1	5.4	2.0	-1.3	1.6	1.5	-2.3	1.5
Number of treatments/medications taken	1.5	2.8	3.6	-1.3	1.5	-1.9	-1.8	1.7	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	8.3	2.4	0.9	2.1	2.9	-1.8	2.6
Number of full sisters	1.5	1.8	3.2	1.4	-1.8	1.3	1.2	-1.5	0.9
Supplements: Vitamin C	1.5	1.8	3.8	1.0	-0.6	0.4	1.6	-1.6	1.9
Osteoporosis (self-reported)	1.5	1.9	4.3	-1.2	1.1	-1.5	-0.8	2.1	-1.3
Number of self-reported non-cancer illnesses	1.5	2.7	3.9	-1.4	0.2	-2.0	-1.9	1.9	-1.7
Schizophrenia (2014)	1.4	3.1	4.5	2.1	-0.4	2.1	1.6	-2.0	1.7
Medication: Lansoprazole	1.4	1.6	2.7	-0.8	-0.6	-1.6	-1.6	1.3	-1.3
Pulse wave peak to peak time	1.4	1.7	3.5	1.4	-0.9	1.9	1.3	-0.4	1.3
Number of operations (self-reported)	1.4	2.1	3.8	-1.5	1.2	-1.9	-1.4	1.4	-1.0
Hearing difficulty/problems with background noise	1.3	2.0	4.6	-1.9	-0.4	-2.1	-1.1	1.2	-0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.0	1.2	1.2	1.0	1.4	-1.3	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.4	1.2	0.1	1.2	1.2	-2.1	1.0
Average weekly red wine intake	1.3	1.8	3.2	0.8	1.8	0.4	1.3	-1.7	1.6
Loneliness, isolation	1.3	1.7	3.5	-1.9	0.8	-0.8	-1.3	1.6	-1.2
Tinnitus: Yes, now most or all of the time	1.3	1.6	2.9	-1.3	-1.4	-1.5	-0.6	1.7	-0.6
Diastolic blood pressure, automated reading	1.3	4.2	7.5	-1.8	0.3	-2.2	-2.3	1.9	-2.7
Mean Putamen Volume	1.2	1.4	2.3	1.1	0.2	1.5	1.5	-0.9	1.3
Primary Biliary Cirrhosis	1.2	1.7	3.0	1.1	0.1	1.2	1.7	-1.4	1.5
Sitting height	1.2	8.4	15.3	3.1	0.5	2.8	3.8	-1.9	3.9
Number of incorrect matches in round	1.2	2.0	6.0	-1.2	2.4	-1.4	-0.9	1.0	-0.9
Hair/balding pattern: Pattern 3	1.2	1.8	4.5	-0.9	0.4	-1.4	-2.1	0.3	-1.8
Prospective memory result	1.2	1.5	3.2	-1.8	0.9	-1.6	-0.7	1.0	-0.9
Illnesses of siblings: Diabetes	1.2	1.5	3.2	-1.5	0.9	-0.6	-1.5	0.0	-1.8
Financial situation satisfaction	1.2	1.5	3.3	1.2	1.8	1.7	0.8	-1.0	0.1
Myopia	1.2	1.8	2.9	1.7	-0.2	1.6	1.2	-1.5	1.3
Qualifications: College or University degree	1.1	3.5	5.8	2.1	0.6	2.3	2.4	-1.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.6	1.7	0.1	1.5	2.1	-0.4	2.0
Triglycerides	1.0	1.6	2.3	-1.2	0.3	-1.5	-1.5	1.3	-1.3
Sensitivity / hurt feelings	1.0	1.7	2.6	-1.3	-1.6	-1.5	-1.2	0.8	-1.4
Hearing difficulty/problems: Yes	1.0	1.5	2.8	-1.7	-0.0	-1.5	-0.9	1.4	-1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-1.6	1.3	-0.6	-0.4	1.3	-0.7
Vitamin and mineral supplements	1.0	1.4	3.7	-1.0	0.0	-1.0	-1.9	1.0	-1.3
Stomach or abdominal pain in last month	1.0	1.3	1.7	1.0	0.9	1.0	1.1	-1.3	1.3
Falls in the last year	1.0	1.4	2.9	-1.3	-0.2	-0.9	-1.7	0.6	-1.6
Pulse wave Arterial Stiffness index	1.0	1.2	2.8	-1.2	0.9	-1.7	-1.1	0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.2	-1.0	1.1	-1.1	-1.6	1.7	-1.8
Overall health rating	1.0	2.1	3.6	-1.9	0.1	-1.1	-1.8	1.2	-1.8
Diabetes diagnosed by doctor	1.0	1.7	2.8	-1.5	-0.5	-1.7	-1.1	1.6	-1.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.6	-1.0	0.2	-0.7	-1.6	0.6	-1.6
Waist Hip Ratio (WHR)	0.9	3.8	6.5	-2.1	-1.9	-2.5	-2.2	1.1	-1.5
Hypothyroidism (self reported)	0.9	2.2	4.7	-0.9	2.2	-1.0	-1.2	1.5	-1.6
Relative age of first facial hair	0.9	1.8	3.4	-1.2	-0.0	-1.3	-1.7	1.2	-1.8
Medication: Co-codamol	0.9	1.0	2.5	-1.6	-0.2	-1.1	-1.0	0.6	-1.1
Severe depression (siblings)	0.9	1.0	2.3	-0.9	-0.6	-0.7	-1.3	0.5	-1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.6	-1.0	-1.3	-1.1	-0.9	1.2	-0.7
Qualifications: None of the above	0.9	1.9	2.8	-1.6	0.1	-1.6	-1.7	0.8	-1.6
Length of working week for main job	0.9	1.0	3.9	0.3	0.9	0.0	0.6	-2.0	0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	1.6	0.8	1.0	0.9	-1.2	0.9
Medication: Paracetamol	0.9	1.5	2.8	1.4	-0.7	1.7	1.1	-1.1	1.1
Gout (self-reported)	0.9	1.2	3.4	-1.5	-0.2	-1.8	-1.0	0.2	-0.7
Neck or shoulder pain in last month	0.9	1.3	2.6	-1.3	-1.3	-1.0	-0.9	1.6	-0.6
Medication: Omeprazole	0.9	1.1	4.8	-0.8	2.2	-0.5	-0.4	0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	-1.4	1.3	-1.1	-0.2	1.2	-0.2
Back pain experienced in last month	0.9	1.3	2.3	0.8	-1.0	1.2	1.1	-1.0	1.5
Commuting to job workplace: Public transport	0.9	1.1	2.4	1.3	0.7	0.6	0.7	-1.6	1.0
Lung FEV1/FVC ratio	0.8	3.9	4.6	2.2	2.0	1.9	1.9	-2.1	1.9
Chronotype (morning person)	0.8	1.8	3.5	-0.7	1.9	-0.4	-1.6	1.2	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	1.1	-0.8	1.6	1.1	-0.1	0.9
High blood pressure (mother)	0.8	1.1	1.9	-1.1	0.4	-0.7	-1.3	1.1	-1.4
Hair/balding pattern: Pattern 2	0.8	1.1	3.1	1.0	0.6	0.8	1.8	-0.2	1.1
Impedance of arm (right)	0.8	3.6	4.9	2.0	1.4	2.2	1.9	-2.2	1.6
Breastfed as a baby	0.8	1.0	2.8	-0.8	-0.0	-1.7	-1.0	0.9	-0.7
Tense / ‘highly strung’	0.8	1.3	4.4	0.7	-2.1	0.5	1.2	-0.3	1.1
Pulse wave reflection index	0.8	1.0	2.1	-1.3	0.1	-1.0	-1.5	0.2	-1.0
Forced vital capacity (FVC), Best measure	0.8	2.8	5.8	1.8	0.3	1.3	2.4	-1.3	2.1
Ever had bowel cancer screening	0.8	0.9	2.8	0.6	-0.6	-0.1	1.7	-0.8	1.2
Miserableness	0.8	1.5	2.7	1.3	0.4	1.3	1.7	-0.9	1.3
Wears glasses or contact lenses	0.8	0.9	1.4	-1.1	-1.2	-0.8	-1.1	0.1	-1.0
Alzheimer’s Disease (in father)	0.7	0.7	1.4	1.2	0.4	0.6	1.0	-0.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.3	-1.5	-2.1	-0.9	-0.7	1.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.0	1.7	0.3	1.7	2.0	-1.0	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.8	0.2	-1.9	0.6	-0.4	-0.3	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.7	0.8	-0.1	1.2	0.5	-1.9	0.5
Long-standing illness, disability or infirmity	0.7	1.0	2.2	-0.2	1.4	-0.7	-1.1	-0.1	-1.5
Average weekly beer plus cider intake	0.7	1.0	2.4	-0.5	-1.6	-0.7	-0.8	1.1	-0.9
Ever depressed for a whole week	0.7	0.9	2.0	0.6	-0.7	0.9	1.0	-0.6	1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	1.0	0.7	0.8	0.3	-1.5	0.6
Ever had hysterectomy (womb removed)	0.6	0.7	2.4	-0.6	-1.5	-0.7	-0.8	0.3	-0.3
Supplements: Zinc	0.6	0.6	1.7	0.4	-1.3	0.5	0.7	1.0	0.6
Trunk fat percentage	0.6	2.6	5.8	1.9	0.8	1.2	1.4	-2.4	1.3
Hip circumference	0.6	2.7	4.0	1.9	0.5	1.5	2.0	-1.7	1.8
Father’s age at death	0.6	0.8	1.5	0.5	-0.9	0.9	0.9	-1.2	0.7
Impedance of arm (left)	0.6	2.9	4.4	1.5	1.7	1.9	1.7	-2.1	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.1	-0.6	1.0	-0.8	-0.8	1.0	-0.7
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.6	1.2	0.8	0.6	-1.0	0.6
Cholesterol lowering medication	0.6	0.8	3.7	0.8	1.9	0.6	0.4	-0.2	0.4
Neuroticism (2016)	0.5	0.7	1.4	-1.2	-0.2	-0.9	-0.4	1.1	-0.3
Ulcerative Colitis	0.5	0.7	2.1	0.9	0.8	0.8	0.3	-1.4	0.1
Tanning	0.5	6.0	10.7	-2.6	0.3	-2.2	-3.2	1.8	-3.3
Average weekly spirits intake	0.5	0.6	2.6	-0.4	0.7	0.2	0.5	-1.6	0.2
Townsend deprivation index at recruitment	0.5	0.7	3.0	-0.3	-1.7	-0.3	-0.4	0.8	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.1	0.4	0.5	1.0	0.9	-0.5	1.1
Trunk fat mass	0.5	2.1	4.2	1.8	0.6	1.1	1.4	-2.0	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	0.0	1.3	0.3	-0.0	-1.1	0.8
Depression (self-reported)	0.5	0.6	1.1	0.7	0.7	1.1	0.6	-0.5	0.7
Body fat percentage	0.5	2.0	4.6	1.8	0.5	1.1	1.1	-2.2	1.2
Leg fat percentage (right)	0.5	1.8	3.8	1.7	-0.0	1.1	1.0	-1.9	1.4
Emphysema/chronic bronchitis	0.5	0.5	2.9	0.2	1.7	0.3	0.1	0.0	-0.1
Medication: Ibuprofen	0.5	0.6	2.9	-0.1	-1.7	0.2	-0.6	0.1	-0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.7	-0.7	-1.0	-0.6	0.9	-0.5
Eye problems/disorders: Cataract	0.5	0.6	3.3	0.3	1.8	-0.1	0.2	-0.4	-0.2
Guilty feelings	0.5	0.8	2.8	-1.0	-0.3	-0.7	-0.3	1.7	-0.4
Hearing aid user	0.5	0.6	1.8	0.5	-1.3	0.8	0.4	-0.7	0.3
Medication: Atorvastatin	0.5	0.7	3.1	0.1	1.7	0.7	0.5	0.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.2	-0.6	1.5	-0.5	-0.3	1.0	-0.4
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.6	0.7	-1.0	-0.6	0.5	-0.6
Bipolar Disorder (2011)	0.4	0.4	2.4	0.0	0.0	0.0	0.0	-1.6	0.0
HDL Cholesterol	0.4	0.6	2.2	0.3	0.5	0.8	0.5	-1.5	0.6
Blood White Count	0.4	2.6	4.5	-2.1	-1.4	-1.4	-1.7	1.1	-1.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	0.8	0.6	0.9	0.7	-0.2	0.8
Diabetes (mother)	0.4	0.4	0.7	0.8	0.5	0.6	0.8	-0.7	0.5
Taking other prescription medications	0.4	0.5	2.7	-0.2	1.6	-0.5	-0.4	0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	0.2	-0.8	-0.5	0.2	-0.8	0.8
Nervous feelings	0.4	0.8	3.0	0.6	-1.7	0.6	0.5	-0.8	0.5
Forced vital capacity (FVC)	0.4	1.4	2.9	1.2	0.2	1.1	1.7	-0.6	1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.9	-0.2	0.5	0.7	-0.9	1.0
Arm fat percentage (right)	0.4	1.6	4.1	1.6	0.0	1.0	0.9	-2.0	1.0
Pulse rate	0.4	0.7	1.3	-0.6	-0.9	-0.6	-1.1	0.1	-1.1
Lung cancer (father)	0.4	0.5	1.6	-0.3	1.3	-0.9	-0.7	0.3	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.1	0.5	-0.2	0.7	0.4	-1.4	-0.0
Loud music exposure frequency	0.4	0.4	2.3	0.4	-1.5	-0.0	0.1	0.2	0.3
Glaucoma (self-reported)	0.4	0.5	1.3	-0.6	-0.0	-0.3	-1.1	0.3	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	-1.1	0.2	-0.1	-1.2	0.0	-0.5
Medication: Seretide 50 evohaler	0.4	0.4	1.9	-0.1	1.4	0.8	0.4	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.2	1.0	-0.0	-0.3	1.3	-0.3
Chest pain or discomfort	0.4	0.5	0.9	0.9	-0.8	0.6	0.5	-0.5	0.9
Arm fat percentage (left)	0.4	1.4	3.9	1.5	0.4	1.0	0.8	-2.0	0.9
Osteoarthritis (self-reported)	0.4	0.5	1.1	-0.6	-0.0	-1.0	-1.0	0.6	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	0.4	0.3	0.3	1.1	-0.8	0.8
Leg fat percentage (left)	0.4	1.3	2.3	1.5	0.5	0.9	1.0	-1.5	1.2
Heart disease (siblings)	0.4	0.5	1.2	-0.7	-0.4	-0.9	-0.4	1.1	-0.6
Impedance of whole body	0.4	2.2	2.9	1.4	1.3	1.6	1.6	-1.7	1.2
Depression (Nagel 2018)	0.3	0.5	1.5	0.4	0.1	1.2	0.8	-0.3	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.3	-0.5	0.3	-1.5	-0.9	0.4	-0.6
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.7	1.2	0.1	0.3	-1.2	0.2
Prostate Cancer	0.3	0.4	2.4	0.2	1.5	0.0	-0.2	-0.3	0.0
Fasting Glucose	0.3	0.3	0.7	0.7	0.8	0.5	0.5	-0.4	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.6	0.4	0.6	0.6	-0.9	0.4
Average weekly fortified wine intake	0.3	0.4	0.7	0.2	-0.9	0.8	0.1	-0.7	0.6
Maternal smoking around birth	0.3	0.5	1.3	-1.1	0.3	-0.7	-0.7	0.8	-0.1
Age when periods started (menarche)	0.3	0.8	2.6	-0.6	-0.4	-1.0	-0.7	-0.1	-1.6
Multivitamins +/- minerals	0.3	0.4	1.4	0.6	-0.0	0.6	1.2	0.0	0.6
Supplements: Glucosamine	0.3	0.4	1.0	-0.5	-0.3	-1.0	0.2	0.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	-0.9	-1.4	-0.7	-0.3	0.8	-0.4
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.9	0.5	-0.5	-0.4	-0.7	-0.3
Headache pain in last month	0.3	0.5	1.3	0.9	0.0	1.1	0.5	0.1	0.8
Health satisfaction	0.3	0.4	0.7	-0.7	-0.6	0.1	-0.8	0.6	-0.7
Whole body fat mass	0.3	1.4	2.9	1.6	0.4	0.9	1.0	-1.7	1.1
Leg fat mass (right)	0.3	1.3	2.6	1.4	-0.1	0.8	1.0	-1.6	1.2
Suffer from ‘nerves’	0.3	0.5	1.4	0.6	-0.1	0.6	0.6	-1.2	0.7
Knee pain experienced in last month	0.3	0.5	1.3	-0.6	0.3	-0.8	-1.1	0.0	-0.9
Qualifications: nursing, teaching	0.3	0.5	1.3	0.8	-1.2	0.5	0.2	0.7	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-0.8	-0.7	-1.0	-0.6	0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.9	0.1	-0.6	-0.4	0.8	-0.6
Arm fat mass (left)	0.3	1.0	2.4	1.3	0.3	0.8	0.9	-1.5	0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.6	-0.6	-0.1	-1.2	-0.4	0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.6	-0.8	-0.1	0.7	-0.3	0.9
High cholesterol (Self-reported)	0.3	0.6	1.8	-0.4	0.8	-1.3	-0.3	0.7	-0.4
Risk taking	0.3	0.5	1.8	-0.6	-0.1	-0.5	-0.4	1.3	-0.5
Commuting to job workplace: Cycle	0.3	0.3	1.1	-0.4	1.1	0.1	-0.4	0.6	-0.4
Alcohol drinker status: Previous	0.3	0.3	0.7	0.1	-0.3	0.7	0.8	-0.3	0.8
Worry (Nagel 2018)	0.2	0.5	1.4	-0.2	-1.1	0.1	0.5	-1.2	0.4
Ovarian Cancer	0.2	0.3	0.6	-0.7	0.5	-0.5	-0.8	0.3	-0.5
Lupus	0.2	0.3	1.0	-0.5	0.3	0.2	-1.0	0.2	-0.7
Rheumatoid Arthritis	0.2	0.3	1.3	-0.4	0.5	-0.1	-0.2	1.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.1	0.1	-1.1	-0.2	0.3	0.3	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.2	-0.8	-0.6	-0.6	0.4	-0.5
Hand grip strength (left)	0.2	0.4	0.9	0.3	-0.9	-0.2	0.8	0.1	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.1	-0.5	-1.0	0.4	0.1	0.7
Leg fat-free mass (left)	0.2	0.8	1.1	1.1	-0.7	0.7	1.0	-1.0	1.0
Fed-up feelings	0.2	0.3	0.9	-0.6	-0.9	-0.5	-0.4	0.2	-0.4
Medication: Levothyroxine sodium	0.2	0.4	1.3	-0.5	1.1	-0.4	-0.7	0.0	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.8	-0.4	0.3	0.2	-0.1	0.8
Impedance of leg (left)	0.2	0.8	1.5	0.5	1.2	0.9	1.1	-0.6	0.7
Leg predicted mass (left)	0.2	0.9	1.2	1.1	-0.6	0.7	1.0	-1.0	1.0
Waist circumference	0.2	0.6	1.4	0.8	0.0	0.2	0.7	-1.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.5	0.7	0.3	0.5	-0.2	0.8
Had menopause	0.2	0.3	0.7	0.6	0.2	0.1	0.8	-0.5	0.7
Mouth/teeth dental problems	0.2	0.3	1.0	0.3	0.7	1.0	0.4	0.3	0.6
Neuroticism score	0.2	0.4	0.7	0.3	-0.6	0.8	0.6	-0.6	0.6
Weight	0.2	0.9	1.6	1.2	0.2	0.5	1.0	-1.2	1.1
Worrier / anxious feelings	0.2	0.4	0.7	0.1	-0.8	0.1	0.7	-0.8	0.7
Noisy workplace	0.2	0.2	0.4	0.6	0.2	0.3	0.6	-0.3	0.6
Arm fat mass (right)	0.2	0.9	2.1	1.3	0.1	0.7	0.8	-1.4	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.7	-1.2	-0.3	-0.8	0.5	-0.5
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.0	0.4	0.4	0.5	-0.7	0.7
Worry too long after embarrassment	0.2	0.4	0.8	0.5	0.3	0.9	0.6	-0.5	0.7
Wheeze or whistling in the chest in last year	0.2	0.3	1.4	0.3	1.2	0.1	0.3	0.3	0.2
Age at first live birth	0.2	0.4	2.1	0.1	1.4	0.0	0.0	0.3	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.0	0.6	0.5	0.6	-0.9	0.7
Comparative height size at age 10	0.2	1.1	3.0	0.6	0.8	0.2	1.6	-0.2	1.7
Age at last live birth	0.2	0.3	1.5	-0.2	-0.1	-0.4	-0.2	1.2	-0.4
Leg pain on walking	0.2	0.2	0.4	0.3	-0.1	0.7	0.5	-0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.8	0.1	0.4	0.5	0.3	0.4
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.4	0.7	-0.6	-0.3	0.4	-0.6
Mood swings	0.2	0.4	0.8	-0.7	0.1	-0.8	-0.4	0.9	-0.4
Mineral and other dietary supplements	0.2	0.2	0.5	0.2	-0.0	0.7	-0.5	-0.6	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.6	0.2	-0.8	-0.1	0.1	-0.4
Age started oral contraceptive pill	0.2	0.2	1.1	-0.2	-1.1	-0.2	-0.1	0.5	0.0
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.6	-0.1	-0.3	-0.8	0.4	-0.7
Pack years of smoking	0.2	0.3	0.8	-0.3	0.8	0.2	0.2	-0.9	0.4
Leg fat mass (left)	0.2	0.9	1.7	1.3	0.2	0.6	0.9	-1.3	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	0.8	1.1	0.3	0.2	-0.1	0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.1	-0.8	0.3	0.5	-0.8	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.0	0.5	-0.4	0.1	0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	0.9	-0.5	0.7	-0.0	0.2	0.2
Age at First Birth	0.1	0.2	0.4	-0.7	0.4	-0.3	-0.4	-0.3	-0.4
Heel T-Score	0.1	1.2	2.1	-1.2	-0.2	-1.1	-1.4	1.1	-1.1
Height	0.1	1.0	2.9	0.1	0.8	0.1	1.7	-0.4	1.4
Neuroticism	0.1	0.2	0.6	0.1	-0.8	0.5	0.2	-0.2	0.2
Diabetes (father)	0.1	0.2	0.3	-0.5	-0.5	0.3	-0.1	0.3	-0.4
Pack years adult smoking proportion	0.1	0.1	0.6	-0.4	0.1	0.2	-0.1	-0.8	0.1
Impedance of leg (right)	0.1	0.6	0.9	0.4	0.6	0.8	0.9	-0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	-0.0	0.2	-0.2	0.0	0.5
Body mass index (BMI)	0.1	0.4	1.3	0.9	-0.2	0.3	0.3	-1.2	0.5
Alcohol usually taken with meals	0.1	0.2	0.5	-0.1	-0.7	-0.4	0.6	-0.4	0.3
Financial difficulties in last 2 years	0.1	0.2	0.9	-0.3	0.1	-0.1	-0.4	-0.1	-0.9
Pain all over the body in last month	0.1	0.1	0.3	0.6	0.2	0.4	0.3	0.1	0.3
Fluid intelligence score	0.1	0.2	0.4	0.7	-0.1	0.3	-0.1	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.6	-0.8	0.0	0.2	0.3	0.4
Number of live births	0.1	0.1	0.3	-0.5	-0.0	-0.0	-0.3	0.5	-0.5
Standing height	0.1	1.1	2.9	0.8	0.7	0.5	1.7	-0.4	1.4
Birth weight of first child	0.1	0.2	0.5	0.4	-0.4	0.4	0.4	0.7	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.8	0.1	-0.6	-0.1	0.2	0.9	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	-0.1	-0.4	0.2	0.5	0.1
Pulse rate, automated reading	0.1	0.3	1.0	0.4	1.0	-0.4	-0.2	0.4	-0.4
Leg fat-free mass (right)	0.1	0.7	1.2	1.1	-0.3	0.7	1.1	-0.7	1.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	0.3	-0.8	0.3	-0.2	0.1	-0.0
Leg predicted mass (right)	0.1	0.6	1.0	1.0	-0.4	0.7	1.0	-0.7	0.9
Ever taken oral contraceptive pill	0.1	0.2	0.4	-0.0	-0.4	0.0	0.5	0.3	0.7
Medication: Paracetamol	0.1	0.2	0.3	0.4	-0.5	0.5	0.3	-0.4	0.4
Alcohol drinker status: Never	0.1	0.1	0.4	0.6	0.5	0.1	-0.1	0.1	0.0
Basal metabolic rate	0.1	0.3	0.6	0.6	-0.4	0.2	0.8	-0.4	0.7
Arm fat-free mass (left)	0.1	0.3	0.7	0.5	-0.5	-0.0	0.8	-0.2	0.8
Pain experienced in last month	0.1	0.2	0.7	-0.3	0.2	-0.8	-0.3	0.4	-0.6
Arm predicted mass (left)	0.1	0.3	0.6	0.4	-0.8	-0.1	0.7	-0.1	0.6
Depressed Affect (Nagel 2018)	0.0	0.0	0.2	-0.4	-0.2	-0.2	0.0	0.1	-0.0
Major Depression (MDD)	0.0	0.1	0.3	0.0	0.0	0.0	0.0	0.2	-0.6
Blood Platelet Count	0.0	0.3	0.8	-0.6	0.2	-0.2	-0.9	0.3	-0.7
BMI	0.0	0.1	0.3	-0.0	0.3	-0.3	-0.6	-0.0	-0.4
Lung FVC	0.0	0.1	0.2	0.5	-0.3	-0.0	-0.2	0.2	0.3
Hair Pigment	0.0	0.2	0.5	0.7	-0.2	0.1	0.1	-0.5	-0.6
Hand grip strength (right)	0.0	0.1	0.2	-0.1	-0.2	-0.5	0.4	0.3	0.3
Had other major operations	0.0	0.1	0.1	0.4	-0.1	-0.0	0.1	-0.2	0.4
Trunk fat-free mass	0.0	0.2	0.3	0.0	-0.6	-0.3	0.5	0.4	0.5
Trunk predicted mass	0.0	0.2	0.3	0.0	-0.6	-0.3	0.5	0.4	0.5
Birth weight	0.0	0.1	0.2	-0.4	-0.2	0.1	0.3	0.4	0.2
Arm fat-free mass (right)	0.0	0.2	0.4	0.4	-0.3	0.1	0.6	-0.1	0.5
Arm predicted mass (right)	0.0	0.2	0.3	0.3	-0.5	-0.1	0.6	-0.0	0.5
Alcohol intake frequency.	0.0	0.0	0.1	-0.1	-0.2	0.2	0.2	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.1	-0.4	0.1	0.4	-0.2	0.3
Whole body fat-free mass	0.0	0.3	0.6	0.5	-0.5	0.1	0.8	-0.1	0.8
Whole body water mass	0.0	0.2	0.5	0.5	-0.3	0.1	0.7	-0.1	0.7
Irritability	0.0	0.1	0.2	0.3	0.4	0.2	0.3	0.2	-0.1

Hub : Genes

HSF2BP

Models

Trait associations