Hub : Genes

RRP1B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.111	0.029	2.0e-10	0.093	0.094	0.092	0.101	0.109	1.9e-11	1.8e-11	2.8e-11	2.6e-12	3.7e-13
2	GTEx	Esophagus Mucosa	0.137	0.042	1.9e-06	0.097	NA	0.110	NA	0.084	5.3e-07	NA	8.0e-08	NA	2.8e-06
3	GTEx	Testis	0.127	0.054	2.5e-03	0.105	NA	0.106	NA	0.096	2.2e-05	NA	2.0e-05	NA	4.8e-05
4	GTEx	Uterus	0.226	0.093	8.4e-03	-0.014	NA	-0.011	NA	-0.008	8.4e-01	NA	6.1e-01	NA	5.1e-01
5	GTEx	Whole Blood	0.064	0.033	7.9e-03	0.016	NA	-0.001	NA	0.004	1.2e-02	NA	4.3e-01	NA	1.3e-01
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.041	0.025	3.7e-03	0.006	0.003	-0.004	NA	0.026	1.1e-01	2.0e-01	8.9e-01	NA	7.1e-03
7	TCGA	Stomach Adenocarcinoma	0.046	0.023	8.5e-05	0.059	0.040	0.043	NA	0.047	4.4e-05	7.2e-04	4.2e-04	NA	2.4e-04
8	TCGA	Thyroid Carcinoma	0.050	0.027	3.1e-03	-0.002	0.009	0.005	NA	0.004	7.2e-01	3.9e-02	9.7e-02	NA	1.1e-01
9	TCGA	Uterine Corpus Endometrial Carcinoma	0.309	0.126	3.5e-03	0.030	0.074	0.012	NA	0.018	5.0e-02	4.3e-03	1.5e-01	NA	1.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.8	2.9	4.6	1.2	1.9	2.0	1.2	1.8	-2.0	-2.1	1.4	-1.0
Bipolar Disorder or Schizophrenia	2.1	5.2	7.5	2.1	2.7	2.5	1.3	2.6	-2.4	-2.6	1.9	-1.9
Depressed Affect (Nagel 2018)	0.3	0.5	2.9	-0.2	-0.5	0.3	-1.7	-0.6	0.2	0.2	-0.8	0.8
Depression (Nagel 2018)	0.2	0.3	0.9	0.6	0.5	0.6	-0.1	0.3	-0.5	-0.5	0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	0.3	0.0	0.6	-1.0	0.0	-0.6	-0.8	-0.9	-0.0
Neuroticism (Nagel 2018)	0.1	0.2	0.8	0.3	0.3	0.9	-0.5	0.4	-0.2	-0.1	-0.3	0.4
Schizophrenia (2018)	1.2	2.5	3.8	1.6	1.9	1.6	0.7	1.9	-1.5	-1.7	1.4	-1.6
Schizophrenia vs Biploar Disorder	0.5	0.7	2.8	0.9	0.7	0.7	-1.7	0.9	-0.6	-0.7	-0.0	-0.5
Worry (Nagel 2018)	0.1	0.2	0.5	0.7	0.1	0.4	0.5	0.7	-0.3	-0.1	0.4	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	-0.9	-0.1	-0.7	-0.7	0.5	0.5	-0.5	-0.5
Alzheimer’s Disease (in father)	1.1	1.1	2.8	0.9	0.7	0.6	-1.4	1.2	-1.0	-1.2	0.3	-1.7
Alzheimer’s Disease (including proxy)	0.5	0.7	4.6	-0.1	-0.6	0.2	-2.1	-0.2	-0.2	-0.3	-0.0	-1.1
Crohns Disease (2017)	1.1	2.4	5.1	-2.3	-1.8	-0.8	-1.1	-1.4	1.8	1.6	-1.5	1.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.6	-0.5	0.1	-0.9	-0.1	0.4	0.2	-0.7	0.8
Ulcerative Colitis (UC)	0.3	0.5	1.1	1.0	0.7	0.7	-0.1	1.0	-0.9	-1.0	0.1	-0.1
Major Depression (MDD)	0.1	0.1	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.1	0.8
Reaction Time	3.4	6.4	9.7	3.1	2.8	2.4	0.3	2.2	-3.0	-3.0	2.9	-1.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.1	-0.1	0.0	0.0	-0.0	0.4	-0.4	-0.7	-1.1	-0.4
Breast Cancer	3.8	9.1	12.5	-3.2	-3.4	-3.0	1.8	-3.1	3.4	3.5	-2.3	3.0
Ovarian Cancer	0.5	0.7	2.5	-0.6	-0.7	0.7	1.5	-0.4	-0.1	0.1	-0.2	1.6
Prostate Cancer	0.1	0.1	0.5	-0.3	0.3	-0.3	-0.1	0.7	0.1	0.0	-0.2	-0.6
Age at First Birth	0.2	0.4	1.3	-0.3	-0.3	-1.1	-0.7	-0.3	0.6	0.6	0.6	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	4.7	6.5	9.7	-3.0	-3.1	-2.0	0.5	-3.1	3.1	3.1	-2.2	1.6
Coronary Artery Disease (CAD)	6.8	8.1	13.3	-3.0	-3.6	-2.9	-0.7	-3.0	2.8	3.1	-2.7	2.8
Crohns Disease (2012)	2.3	3.8	7.2	-2.7	-2.4	-1.2	-0.6	-2.1	2.4	2.2	-1.9	0.8
Mean Putamen Volume	2.6	3.0	8.7	1.0	1.5	1.3	2.0	1.7	-1.4	-1.4	2.9	-1.7
Fasting Glucose	0.3	0.3	1.3	0.3	0.1	0.2	-0.6	0.3	-0.7	-0.8	0.2	-1.1
HbA1C	1.5	1.7	2.5	1.5	1.5	1.2	-0.9	1.6	-1.3	-1.5	1.2	-0.8
HDL Cholesterol	0.7	1.2	1.8	1.3	1.1	1.1	0.9	1.3	-1.2	-0.9	0.9	1.0
LDL Cholesterol	1.3	2.1	3.4	1.5	1.9	1.7	-0.5	1.7	-1.6	-1.6	0.8	-1.0
Lupus	0.3	0.5	1.1	-1.0	-0.4	-0.5	0.8	-0.2	0.9	1.1	0.5	0.6
Neuroticism (2016)	0.5	0.8	2.0	-0.8	-1.0	-0.4	-0.3	-0.6	0.8	1.0	-1.0	1.4
Primary Biliary Cirrhosis	1.3	1.9	4.9	2.2	1.0	1.2	1.0	1.3	-1.7	-1.7	0.7	-1.1
Rheumatoid Arthritis	0.4	0.6	2.5	-0.6	-0.6	-0.5	1.6	-0.9	0.7	0.5	0.2	-0.2
Schizophrenia (2014)	1.3	2.9	4.6	1.5	1.9	1.6	1.1	1.9	-1.6	-1.8	1.7	-2.1
Triglycerides	1.2	2.0	3.1	-1.6	-1.6	-1.7	-0.6	-1.3	1.7	1.8	-1.0	1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.6	0.2	0.0	-0.1	-1.6	0.5	-0.3	-0.3	0.2	-0.0
Ulcerative Colitis	1.0	1.4	2.8	1.4	1.0	1.7	1.0	1.6	-1.2	-1.3	-0.0	-0.5
Blood Eosinophil Count	2.2	16.7	30.5	-4.5	-5.5	-4.0	0.3	-5.1	4.8	4.5	-3.4	1.6
Blood Platelet Count	0.1	1.1	2.9	-1.1	-0.7	-0.6	1.2	-0.7	0.6	0.6	-1.4	1.7
Blood Red Count	1.9	18.7	27.3	-4.6	-5.2	-4.6	-0.9	-4.9	5.2	4.9	-4.6	1.7
Blood White Count	0.4	2.6	3.7	-1.6	-1.9	-1.8	1.6	-1.3	1.4	1.5	-1.5	1.9
Heel T-Score	0.2	1.3	2.5	-1.5	-1.6	-1.2	0.0	-1.3	1.2	1.1	-0.6	0.8
BMI	0.2	1.1	5.7	-0.5	0.2	0.8	2.4	-0.4	0.6	0.5	-0.9	1.4
Height	0.0	0.5	2.8	0.7	0.7	0.2	0.1	0.8	-0.4	-0.1	1.7	0.1
Waist Hip Ratio (WHR)	0.9	4.1	8.5	-2.9	-2.3	-2.2	-1.1	-2.4	2.0	2.1	-1.6	0.9
Systolic Blood Pressure	5.2	26.0	36.5	-5.6	-6.0	-5.2	-1.9	-5.6	6.0	5.8	-5.7	1.6
Smoking Status	2.7	6.3	11.8	-3.4	-3.4	-2.6	0.2	-2.9	2.8	2.7	-1.6	1.2
Allergy or Eczema	4.8	12.7	18.2	3.5	4.3	3.5	1.2	3.9	-3.7	-4.1	3.2	-3.7
Cardiovascular Disease	5.1	16.8	26.9	-5.2	-5.0	-3.7	-1.9	-4.7	4.7	4.4	-4.0	1.8
Hypothyroidism (self reported)	0.4	0.9	1.8	-1.3	-0.6	-0.4	0.5	-0.7	1.2	1.2	-1.3	0.9
Respiratory disease	1.0	2.2	5.6	1.5	1.6	1.5	0.4	1.1	-1.3	-1.7	1.1	-2.4
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.7	-0.3	-0.7	-0.2	-0.6	-0.0	0.1	0.0	-1.3	0.4
Lung FEV1/FVC ratio	0.6	2.8	5.9	1.5	2.0	1.4	-1.6	2.4	-1.7	-1.8	0.4	-1.6
Lung FVC	0.1	0.4	1.5	-0.3	0.1	0.3	-0.6	0.6	-0.4	-0.5	-1.2	-0.9
Neuroticism	0.0	0.1	0.2	0.3	0.1	0.4	0.4	0.4	-0.1	-0.0	-0.1	0.5
Chronotype (morning person)	0.7	1.6	3.8	-1.6	-1.1	-1.2	-0.4	-1.2	1.2	1.1	-1.9	1.2
Hair Pigment	0.0	0.9	3.1	1.2	0.6	1.7	1.3	0.8	-0.6	-0.5	0.5	0.7
Tanning	0.4	4.8	7.2	-2.3	-2.1	-2.2	-1.2	-2.0	2.4	2.7	-1.9	2.5
Hand grip strength (left)	0.0	0.1	0.4	-0.1	0.1	0.5	0.6	0.2	-0.2	-0.1	0.4	-0.5
Number of treatments/medications taken	1.3	2.4	4.0	-1.6	-1.7	-1.2	-0.5	-1.6	2.0	1.8	-2.0	0.6
Average weekly spirits intake	1.0	1.2	3.4	1.2	0.5	1.0	1.9	0.6	-0.9	-0.5	1.2	1.3
Sensitivity / hurt feelings	0.7	1.2	2.2	-0.4	-1.3	-1.5	-0.8	-0.8	1.3	1.4	-1.1	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.4	0.5	0.7	-0.5	0.4	-0.5	-0.5	-0.1	-0.8
Hearing difficulty/problems: Yes	1.5	2.3	4.5	-1.1	-1.8	-1.2	1.3	-1.6	1.6	1.8	-0.8	2.1
Relative age of first facial hair	1.5	3.0	5.3	-1.6	-1.5	-2.1	0.5	-1.5	2.0	2.0	-2.3	1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.9	0.4	0.3	0.9	0.3	0.3	-0.3	-0.3	0.8	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.6	-0.4	-0.4	-0.2	-1.3	-0.4	0.5	0.4	-0.3	-0.6
Ever had hysterectomy (womb removed)	0.9	1.1	1.8	-1.0	-1.4	-0.9	-1.3	-1.2	1.1	0.9	-0.3	0.8
Systolic blood pressure, automated reading	1.5	4.2	8.4	-2.4	-2.2	-1.3	-0.2	-2.4	2.5	2.2	-2.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	-0.0	-1.5	-0.8	1.6	-0.6	0.5	0.7	0.0	0.6
Angina	3.1	4.1	7.4	-2.7	-2.0	-2.2	-2.2	-2.2	2.3	1.9	-1.4	-0.3
Medication for hormone replacement therapy	2.8	3.2	8.4	-1.8	-2.0	-2.9	0.2	-1.5	2.1	2.1	-1.1	0.1
Vitamin and mineral supplements	1.6	2.1	5.7	-1.5	-1.0	-1.4	-1.5	-1.3	1.4	1.3	-2.4	0.5
Supplements: Zinc	0.9	1.0	4.6	0.6	0.2	0.8	1.6	0.1	-0.6	-0.5	2.2	-0.1
Medication: Co-codamol	1.4	1.6	4.1	-0.9	-1.2	-1.2	-0.0	-1.1	1.3	1.5	-1.1	2.0
Medication: Metformin	2.1	3.0	6.2	-1.6	-2.2	-1.4	-1.8	-2.0	1.5	1.4	-2.5	0.9
Diabetes (father)	0.2	0.2	0.7	0.2	-0.4	-0.0	0.8	-0.4	0.2	0.3	-0.4	0.7
Diabetes (mother)	0.6	0.8	2.5	0.9	0.5	1.6	1.3	0.2	-0.8	-0.9	0.7	0.1
Severe depression (siblings)	0.7	0.8	1.6	-0.8	-1.1	-0.8	0.8	-0.3	0.9	0.8	-1.3	0.9
Pack years adult smoking proportion	0.1	0.1	0.3	0.1	-0.4	0.2	0.3	-0.1	-0.2	-0.2	0.6	0.3
Impedance of leg (right)	0.2	1.2	2.4	1.5	0.5	-0.3	-1.5	1.0	-1.2	-0.9	1.3	-0.9
Leg fat-free mass (left)	0.3	1.4	4.4	0.5	1.2	1.8	2.1	1.2	-0.7	-0.7	0.7	0.6
Trunk fat percentage	1.1	4.6	10.6	2.1	2.5	3.3	2.1	2.1	-2.1	-1.9	1.1	1.5
Hand grip strength (right)	0.0	0.1	0.2	-0.2	-0.3	0.1	0.4	-0.2	0.0	0.0	-0.4	-0.2
Townsend deprivation index at recruitment	0.6	0.9	3.3	-0.6	-0.5	-0.9	1.8	-0.1	0.4	0.3	0.9	-1.4
Current tobacco smoking	1.0	1.6	3.2	-1.7	-1.8	-1.1	-0.8	-1.4	1.3	1.2	-1.1	-0.2
Average weekly fortified wine intake	0.6	0.7	2.1	0.8	0.9	1.4	1.4	0.2	-0.5	-0.3	0.8	0.6
Maternal smoking around birth	1.0	1.4	3.9	-0.5	-1.1	-0.8	-0.4	-1.0	0.9	1.0	-1.9	2.0
Fed-up feelings	0.6	1.1	3.9	-0.2	-0.8	0.2	-1.7	-0.4	0.3	0.4	-1.4	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.0	0.4	0.6	0.8	-0.4	0.6	-0.6	-0.8	1.2	-1.4
Relative age voice broke	1.5	2.3	3.9	1.5	1.8	0.8	-0.1	1.9	-1.6	-1.9	0.6	-2.0
Taking other prescription medications	0.2	0.3	0.6	-0.5	-0.5	-0.0	0.3	-0.5	0.8	0.7	-0.6	0.7
Age when periods started (menarche)	0.3	0.7	3.2	0.1	-0.1	0.4	-1.8	-0.3	0.0	0.2	-0.5	1.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	5.8	-0.2	-0.4	0.4	-2.4	-0.4	-0.0	-0.0	-1.7	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	-0.8	-1.3	-1.4	0.8	-1.2	1.2	1.4	-0.1	1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-0.6	0.3	0.2	-1.0	-0.7	-0.1	-0.2	-0.7	-0.1
Qualifications: CSEs or equivalent	2.2	2.9	5.5	2.4	1.3	0.9	1.0	2.2	-2.0	-1.8	2.1	-0.9
Serious illness, injury or assault to yourself	1.2	1.4	7.9	0.6	0.6	0.4	0.2	1.0	-0.8	-0.6	2.8	-1.4
High blood pressure	5.8	16.1	23.9	-4.8	-4.8	-3.3	-1.7	-4.9	4.8	4.6	-3.3	2.6
Hayfever, allergic rhinitis or eczema	5.9	12.8	22.8	3.2	3.9	3.2	1.8	3.7	-3.5	-4.0	3.4	-4.8
Multivitamins +/- minerals	1.7	2.2	7.1	1.3	0.5	0.6	2.3	1.1	-1.3	-1.2	2.7	-1.0
Stomach or abdominal pain in last month	0.7	0.9	1.5	0.5	0.7	1.1	0.8	0.9	-1.1	-1.2	1.1	-0.7
Supplements: Glucosamine	0.7	0.9	2.4	-0.5	-0.6	-1.2	1.2	-0.7	0.8	0.9	1.5	-0.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.8	-1.2	-1.3	-0.5	-0.9	-1.7	0.9	0.8	-1.6	0.0
Medication: Atenolol	3.9	4.9	8.4	-2.5	-2.5	-2.9	-1.2	-2.0	2.5	2.5	-2.0	1.3
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.9	-0.4	-0.6	0.7	-0.0	0.4	0.5	-0.5	0.8
Sitting height	0.9	6.2	9.8	2.4	2.8	2.5	2.2	3.1	-2.6	-2.6	1.7	-2.3
Chronic bronchitis/emphysema (father)	0.2	0.3	1.8	-0.6	0.1	0.3	0.3	0.1	0.1	-0.3	0.1	-1.3
High blood pressure (mother)	1.5	2.1	8.6	-1.3	-1.2	-0.2	-0.4	-1.1	1.5	1.4	-2.9	1.2
Body mass index (BMI)	0.4	1.6	5.1	0.3	1.1	2.0	2.3	0.7	-0.7	-0.7	0.2	1.4
Impedance of leg (left)	0.3	1.2	2.6	1.6	0.6	-0.0	-0.9	1.1	-1.4	-1.1	1.5	-1.0
Leg predicted mass (left)	0.3	1.5	4.6	0.6	1.3	1.9	2.1	1.2	-0.7	-0.7	0.7	0.6
Trunk fat mass	1.0	4.2	10.1	1.7	2.2	3.2	2.6	2.0	-1.8	-1.7	1.2	1.4
Waist circumference	0.3	1.1	3.5	0.5	0.9	1.9	1.4	0.7	-0.8	-0.7	0.1	1.3
Number of incorrect matches in round	0.5	0.8	1.9	-0.7	-1.4	-0.4	0.2	-1.0	0.8	0.9	-0.6	1.3
Past tobacco smoking	3.0	5.5	9.4	3.1	2.8	3.1	-2.0	2.2	-2.5	-2.4	1.1	-0.8
Alcohol usually taken with meals	0.3	0.4	1.7	0.6	0.4	0.5	0.5	0.6	-0.7	-0.5	1.3	-0.5
Nervous feelings	0.1	0.2	0.5	0.4	0.5	-0.1	-0.2	0.7	-0.3	-0.1	0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	-0.1	0.2	0.9	0.8	0.2	-0.1	-0.1	0.3	-0.5
Hearing difficulty/problems with background noise	2.8	4.4	7.3	-1.6	-2.3	-0.9	-0.4	-2.5	2.1	2.4	-2.7	2.7
Hair/balding pattern: Pattern 2	0.6	0.8	3.0	1.7	0.8	1.0	-0.3	0.9	-0.7	-0.6	-0.6	-0.2
Had menopause	0.6	0.7	1.8	0.7	0.5	1.1	-1.1	0.3	-0.6	-0.7	0.6	-1.3
Had other major operations	0.1	0.2	0.6	0.2	0.4	0.8	-0.2	-0.1	-0.3	-0.3	0.7	-0.0
Forced vital capacity (FVC)	0.5	1.9	4.1	1.6	1.4	1.0	0.9	2.0	-1.6	-1.4	0.8	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.5	-0.6	-1.1	-1.6	0.1	-1.0	1.0	1.1	0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	1.1	1.2	1.0	-0.0	1.3	-0.8	-0.7	-0.1	-0.5
Qualifications: None of the above	1.1	2.4	4.1	-1.7	-1.5	-1.3	-0.0	-1.7	1.7	1.5	-2.0	1.7
Financial difficulties in last 2 years	0.5	0.6	2.5	0.3	-0.1	0.3	-1.6	-0.5	0.2	0.1	-0.8	1.4
Mouth/teeth dental problems	0.1	0.1	0.4	0.0	0.2	0.1	0.6	0.2	-0.1	-0.1	0.2	-0.4
Heart attack	2.2	2.8	4.8	-2.2	-2.0	-1.6	-0.8	-1.3	2.2	1.9	-1.8	0.5
Allergy	3.3	7.6	16.6	-2.2	-2.7	-2.1	-2.4	-2.5	2.5	2.9	-3.0	4.1
Pain all over the body in last month	0.5	0.6	3.1	-0.4	-0.3	-0.5	-0.4	-0.7	0.6	0.2	-0.8	-1.8
Diabetes (self-reported)	2.2	3.3	6.7	-1.5	-2.6	-1.5	-1.2	-2.2	1.7	1.6	-2.4	1.2
Hayfever/allergic rhinitis (self-reported)	8.6	11.4	29.9	2.8	3.4	2.6	0.5	3.3	-3.1	-3.5	3.7	-5.5
Medication: Ramipril	3.4	4.3	8.2	-2.4	-2.5	-1.7	-0.9	-2.3	2.9	2.6	-1.5	0.6
Medication: Simvastatin	2.1	3.1	4.1	-1.8	-2.0	-1.4	-1.6	-1.8	1.8	1.9	-2.0	1.5
Fluid intelligence score	0.2	0.5	2.5	-0.2	-0.1	-0.3	0.0	0.2	-0.0	-0.4	-1.1	-1.6
Illnesses of siblings	3.0	4.2	7.3	1.7	2.7	2.2	-0.0	2.5	-2.3	-2.3	2.0	-1.4
Neuroticism score	0.1	0.3	0.8	0.7	0.2	0.7	0.0	0.9	-0.5	-0.4	0.2	0.5
Weight	0.4	2.2	6.4	0.8	1.4	2.4	2.5	1.2	-1.0	-0.9	0.7	1.2
Impedance of arm (right)	0.9	4.3	9.3	3.0	2.4	1.9	-0.1	2.2	-2.5	-2.1	2.1	-0.5
Arm fat percentage (right)	1.0	3.9	9.4	1.5	2.1	3.1	2.6	1.6	-1.6	-1.5	0.7	2.0
Trunk fat-free mass	0.1	0.3	1.7	-0.5	-0.0	0.8	1.3	0.0	0.3	0.2	0.2	0.2
Hip circumference	1.0	4.4	10.5	2.0	2.3	3.2	2.2	2.2	-2.0	-1.8	1.3	1.3
Time employed in main current job	3.3	3.8	7.6	-2.8	-1.8	-1.8	-0.1	-2.5	2.5	2.2	-1.6	0.0
Alcohol intake versus 10 years previously	7.2	10.7	15.5	-3.4	-3.8	-2.3	-2.2	-3.9	3.8	3.5	-3.8	2.0
Father’s age at death	0.8	1.0	2.6	1.1	1.6	1.3	-0.2	1.3	-0.9	-0.5	0.3	0.9
Worrier / anxious feelings	0.1	0.1	0.7	0.8	-0.0	0.1	0.3	0.6	-0.2	-0.1	-0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-0.3	-0.8	-0.1	-0.8	-0.8	0.4	0.5	-1.2	0.9
Falls in the last year	1.6	2.1	5.5	-1.4	-1.0	0.3	-0.0	-1.5	1.7	1.7	-1.7	2.4
Hair/balding pattern: Pattern 3	1.2	1.7	5.7	-1.6	-1.0	-0.4	-0.5	-1.1	1.2	1.0	-2.4	1.6
Number of live births	0.3	0.5	1.4	-0.2	-0.6	-1.2	1.1	-0.4	0.5	0.7	0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.3	2.0	1.9	1.5	0.5	2.5	-2.2	-2.0	0.7	-1.5
Pulse rate	0.5	0.9	2.5	-0.9	-0.5	-0.9	1.2	-1.0	0.6	0.6	-1.6	1.0
Happiness	4.0	4.9	9.0	1.9	2.4	1.4	1.9	2.8	-1.9	-1.8	3.0	-2.2
Noisy workplace	0.2	0.3	1.3	0.2	0.3	0.3	-1.1	0.2	-0.1	-0.2	-0.0	-0.9
Qualifications: A levels/AS levels or equivalent	3.2	7.2	11.1	2.7	3.3	3.1	0.0	3.3	-2.8	-2.8	2.6	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	0.3	0.2	0.0	0.6	0.6	-0.3	0.1	1.0	0.8
Mouth/teeth dental problems: Dentures	4.0	6.7	10.0	-2.9	-3.0	-2.6	-1.0	-3.2	2.8	2.7	-2.7	1.7
Asthma	1.3	2.6	5.2	1.5	1.3	0.9	0.9	1.1	-1.6	-1.8	2.3	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.9	0.1	0.1	0.1	0.6	0.3	0.0	-0.0	-1.4	-0.4
Medication: Cholesterol lowering	3.9	6.0	9.9	-2.8	-3.1	-2.5	-0.7	-2.2	3.0	2.9	-2.2	1.3
Depression (self-reported)	0.4	0.5	0.9	0.2	0.7	0.7	0.6	0.9	-0.5	-0.6	0.7	-0.9
Medication: Lansoprazole	2.6	2.9	5.3	-2.2	-2.0	-1.9	-2.3	-1.6	1.7	1.3	-0.8	-0.7
Prospective memory result	2.1	2.6	7.6	-0.6	-1.6	-0.6	-0.6	-1.7	1.3	1.3	-2.4	2.8
Lung cancer (father)	1.8	2.1	8.5	-1.0	-0.9	-0.5	-2.9	-1.4	0.9	0.6	-2.4	-0.1
Illnesses of mother	4.3	5.3	8.2	2.9	2.7	1.9	-1.1	2.4	-2.8	-2.7	2.5	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	11.0	3.0	2.6	2.1	-0.1	3.3	-3.0	-2.7	1.3	-1.9
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	-0.9	-0.9	-0.5	-1.0	-1.1	0.9	1.1	-0.7	1.4
Impedance of arm (left)	0.7	3.3	8.5	2.9	2.0	1.3	-0.2	2.0	-2.2	-1.8	1.9	-0.2
Arm fat mass (right)	0.7	2.8	7.1	1.0	1.7	2.7	2.6	1.2	-1.2	-1.1	0.6	1.7
Trunk predicted mass	0.1	0.3	1.8	-0.5	-0.0	0.8	1.3	0.1	0.3	0.2	0.2	0.2
Standing height	0.1	1.1	2.7	1.0	1.0	1.0	0.9	1.2	-0.8	-0.7	1.6	-0.6
Length of working week for main job	1.1	1.2	3.4	0.2	1.5	1.3	1.8	0.5	-0.6	-0.4	1.0	1.3
Exposure to tobacco smoke at home	0.5	0.5	3.7	0.2	-0.4	-0.4	0.6	0.2	0.1	0.5	0.1	1.9
Breastfed as a baby	0.5	0.6	0.9	-0.9	-0.9	-0.9	0.5	-0.3	0.9	1.0	-0.8	-0.3
Tense / ‘highly strung’	0.3	0.6	1.2	0.9	0.6	0.6	0.1	1.1	-0.8	-0.8	0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.7	-1.6	-1.5	-1.3	1.9	-1.8	2.1	2.2	-1.0	1.7
Hair/balding pattern: Pattern 4	0.2	0.4	3.0	-0.2	-0.5	-0.5	1.7	-0.0	0.1	0.3	0.2	0.3
Birth weight of first child	0.3	0.5	2.8	0.7	-0.0	0.7	-1.7	-0.2	-0.3	-0.4	0.7	-0.6
Peak expiratory flow (PEF)	0.1	0.2	1.5	-0.3	-0.4	0.1	0.1	0.0	-0.0	-0.1	-1.2	-0.5
Pulse wave reflection index	1.1	1.3	2.8	-1.3	-0.9	-1.3	-0.2	-0.9	1.5	1.7	-0.1	1.5
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.1	1.4	1.0	1.3	0.8	0.8	-0.7	-0.5	-0.6	1.5
Loud music exposure frequency	0.4	0.4	1.2	-0.3	-0.5	-0.5	-0.9	-0.6	0.2	0.1	-1.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.3	1.0	1.5	1.4	1.3	1.3	-0.9	-0.6	1.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.2	0.6	1.5	1.4	0.5	1.3	-1.0	-1.1	1.2	-0.7
Blood clot in the leg (DVT)	1.4	1.8	2.9	-1.7	-1.6	-1.4	-0.5	-1.0	1.5	1.4	-1.0	1.4
Medication: Paracetamol	0.8	1.3	3.1	1.1	1.4	1.8	1.3	1.0	-1.2	-1.1	0.1	0.6
Headache pain in last month	0.4	0.6	3.0	-0.5	0.0	0.1	-0.1	-0.1	0.3	-0.1	-1.5	-1.7
Medication for cholesterol, blood pressure or diabetes	9.2	15.2	21.2	4.0	4.6	3.5	0.3	4.0	-4.6	-4.6	4.0	-3.6
Glaucoma (self-reported)	0.5	0.6	1.5	-0.4	-0.3	-0.8	0.9	-0.9	0.8	0.8	1.2	-0.1
Gout (self-reported)	0.9	1.2	6.7	-0.8	-1.0	0.1	0.6	-0.9	0.6	0.7	-0.6	2.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.8	-2.0	-0.9	-0.9	0.1	-1.0	1.5	1.4	-1.5	0.3
Medication: Amlodipine	2.6	3.6	5.2	-1.7	-2.1	-1.0	-0.5	-2.2	2.2	2.2	-2.0	2.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-0.2	-0.8	-1.0	0.1	-0.9	0.7	0.6	0.5	-0.3
Birth weight	0.3	0.6	3.5	-0.6	-0.3	-0.7	0.4	-0.2	0.3	0.4	1.9	-0.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.3	-1.0	-0.8	-1.5	1.1	-0.5	1.0	1.1	-0.2	1.4
High blood pressure (siblings)	5.5	7.9	12.1	-2.6	-3.5	-3.2	-0.8	-3.3	3.3	3.3	-2.6	1.5
Forced vital capacity (FVC), Best measure	1.1	3.9	7.5	2.4	2.0	1.6	0.2	2.7	-2.4	-2.1	1.3	-1.7
Body fat percentage	1.0	4.0	9.7	1.7	2.2	3.1	2.3	1.9	-1.9	-1.7	1.0	1.5
Leg fat percentage (right)	0.7	2.6	7.0	1.2	1.8	2.7	1.5	1.7	-1.7	-1.6	1.0	0.7
Arm fat-free mass (right)	0.1	0.5	2.2	-0.1	0.5	1.1	1.5	0.6	-0.1	-0.2	0.3	0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.3	0.4	0.7	0.3	0.8	0.7	-0.3	-0.1	1.1	1.1
Comparative body size at age 10	2.6	7.2	9.5	-3.0	-2.8	-3.0	-0.0	-2.9	3.0	3.1	-2.5	2.2
Number of full brothers	2.5	3.2	7.4	1.2	2.1	1.1	2.1	1.8	-1.8	-1.7	2.7	-0.7
Worry too long after embarrassment	0.5	0.8	2.6	0.4	0.9	1.2	1.6	0.6	-0.5	-0.3	1.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.2	-2.0	-0.9	-0.4	1.5	-1.5	1.5	1.3	-0.5	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.4	-0.3	-0.8	0.2	-0.0	-0.3	-0.1	-0.4	0.5	-1.2
Number of children fathered	3.1	3.5	7.1	-1.2	-2.4	-2.2	-1.4	-1.5	1.6	1.8	-2.7	1.7
Reason for reducing amount of alcohol drunk: Health precaution	4.2	4.9	7.5	-2.3	-2.7	-2.3	-0.4	-2.5	2.7	2.7	-2.2	-0.5
Age at first live birth	0.2	0.3	1.0	0.2	0.3	-0.8	-0.3	0.9	0.0	0.1	-0.3	-1.0
Pulse wave peak to peak time	1.2	1.4	2.4	1.1	1.1	0.6	1.1	1.4	-1.1	-1.2	1.1	-1.6
Health satisfaction	0.5	0.7	2.1	-0.9	-0.5	-0.1	1.5	-0.7	0.5	0.5	-0.5	1.3
Shortness of breath walking on level ground	1.5	1.7	3.3	-1.1	-1.3	-0.3	1.3	-1.8	1.3	1.4	-0.5	1.8
Qualifications: College or University degree	1.3	4.0	6.2	2.3	2.3	1.6	1.5	2.1	-1.9	-1.9	1.5	-2.5
Eye problems/disorders: None of the above	1.0	1.1	2.3	1.0	1.2	1.5	-0.3	1.0	-1.3	-1.3	-0.8	-0.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	6.0	1.5	1.2	0.5	2.5	1.7	-1.2	-1.1	0.9	-1.2
Emphysema/chronic bronchitis	0.1	0.2	0.6	-0.1	-0.2	0.1	0.4	-0.2	0.2	0.1	-0.8	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	4.4	0.4	0.6	-0.2	-0.1	0.4	-0.5	-0.3	2.1	-0.6
Neck or shoulder pain in last month	1.7	2.4	5.0	-1.6	-1.8	-1.7	-0.7	-2.2	2.0	1.7	-1.1	0.2
Medication: Blood pressure	10.9	19.2	25.8	-4.5	-5.1	-4.2	0.1	-4.7	5.1	5.1	-4.7	3.7
Angina (self-reported)	3.3	4.3	8.3	-2.9	-1.9	-2.2	-2.3	-2.1	2.3	2.0	-1.6	-0.1
Migraine (self-reported)	1.1	1.3	2.2	1.0	1.1	1.5	-0.4	1.2	-1.3	-1.4	0.7	-1.3
Medication: Ibuprofen	0.3	0.3	1.3	-0.4	-0.3	-0.7	0.4	-0.2	0.5	0.5	-1.1	-0.6
Medication: Allopurinol	0.7	1.0	3.5	-1.1	-1.3	-0.4	0.4	-0.9	0.8	0.9	-0.2	1.9
Medication: Omeprazole	0.6	0.7	2.2	-0.4	-0.8	0.6	-0.3	-0.6	0.7	0.7	-1.5	1.4
Medication: Seretide 50 evohaler	0.5	0.5	2.2	0.7	0.4	-0.4	1.5	0.8	-0.3	-0.1	1.0	-0.2
Mean time to correctly identify matches	3.3	6.4	11.0	2.9	2.8	2.3	0.5	2.3	-2.9	-2.8	3.3	-1.7
Heart disease (mother)	1.6	2.0	4.0	-1.4	-1.7	-1.2	0.8	-1.5	2.0	2.0	-0.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.2	-0.1	-0.5	-0.0	-1.5	-0.2	-0.4	-0.6	0.3	-1.3
Whole body fat mass	0.8	3.3	7.6	1.2	1.8	2.7	2.8	1.6	-1.5	-1.4	1.0	1.3
Leg fat mass (right)	0.6	2.3	5.7	0.9	1.6	2.4	2.3	1.4	-1.2	-1.2	0.9	1.0
Arm predicted mass (right)	0.1	0.3	1.7	-0.2	0.3	0.9	1.3	0.5	-0.0	-0.1	0.2	0.2
Pulse rate, automated reading	0.1	0.4	0.9	0.0	0.1	0.6	-0.7	-0.3	-0.6	-0.8	-0.9	-0.9
Alcohol intake frequency.	0.2	0.4	1.5	-0.3	-0.4	-0.1	-1.0	-0.5	0.5	0.2	-1.2	0.1
Comparative height size at age 10	0.1	0.5	0.9	0.6	0.4	0.8	-0.5	0.3	-0.8	-0.9	0.7	-0.9
Number of full sisters	1.0	1.3	2.7	1.6	1.2	-0.1	1.6	1.3	-1.1	-1.1	-0.0	-0.9
Suffer from ‘nerves’	0.5	0.8	2.3	0.7	1.0	1.1	0.2	1.0	-0.8	-0.6	1.5	-0.2
Overall health rating	1.3	2.8	4.6	-1.6	-2.0	-0.5	0.8	-2.0	1.9	2.0	-1.4	2.1
Chest pain or discomfort	0.2	0.4	2.1	0.2	0.3	-0.2	0.3	0.6	-0.3	-0.5	0.5	-1.4
Had major operations	8.8	10.3	14.6	-3.0	-3.4	-3.0	-0.9	-3.3	3.6	3.7	-3.3	3.8
Age at last live birth	0.5	0.7	2.9	-0.8	-0.3	-1.5	-0.0	0.1	0.6	0.5	0.3	-1.7
Family relationship satisfaction	2.3	2.8	6.5	1.0	1.8	1.9	1.0	1.8	-1.4	-1.5	2.6	-1.5
Leg pain on walking	0.1	0.1	0.5	0.3	0.0	-0.1	-0.6	-0.1	-0.1	-0.1	-0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	3.2	1.7	1.4	1.6	1.1	1.8	-1.7	-1.4	1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	-1.1	-1.0	-0.3	-1.1	-1.2	1.0	0.9	-0.7	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-0.1	0.2	0.7	-0.2	-0.1	-0.2	-0.6	-1.2	-1.2
Medication: Aspirin	2.1	2.8	5.0	-1.8	-1.9	-2.2	-1.2	-1.5	1.8	1.6	-1.9	-0.0
Supplements: Vitamin C	0.3	0.4	1.1	1.0	0.6	0.9	0.0	0.4	-0.7	-0.7	0.1	0.4
Knee pain experienced in last month	0.7	1.0	2.3	-0.7	-0.8	-0.6	-1.3	-0.9	1.0	1.1	-0.9	1.5
Hypertension (Self-reported)	5.3	14.7	21.5	-4.5	-4.6	-3.1	-1.8	-4.6	4.6	4.5	-2.9	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.4	-0.7	-1.0	0.2	-1.5	-1.1	0.7	0.5	-1.5	0.7
Illnesses of father: Heart disease	0.3	0.5	0.9	-0.7	-0.8	-0.8	0.1	-0.7	0.8	0.7	-0.9	0.2
Illnesses of siblings: Diabetes	1.6	1.9	7.7	-0.8	-0.9	-0.4	1.5	-1.0	1.0	1.3	-1.4	2.8
Smoking status: Previous	3.2	4.8	8.8	-3.0	-2.6	-2.9	1.2	-2.3	2.4	2.2	-0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.5	0.1	0.5	-0.2	-0.1	-0.7	-0.6	0.8	0.2
Whole body fat-free mass	0.1	0.6	3.1	-0.1	0.5	1.3	1.8	0.6	-0.1	-0.2	0.5	0.3
Leg fat-free mass (right)	0.3	1.5	5.2	0.5	1.3	1.8	2.3	1.2	-0.7	-0.7	0.8	0.5
Arm fat percentage (left)	0.9	3.6	8.1	1.5	2.0	2.8	2.6	1.6	-1.6	-1.4	0.7	2.0
Average weekly red wine intake	0.8	1.2	2.7	1.2	1.0	0.3	-1.6	1.4	-1.3	-1.0	0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	0.0	0.4	1.1	0.0	0.1	-0.6	-0.6	-0.5	0.0
Mood swings	0.8	1.4	6.2	-0.8	-1.2	-0.8	-2.5	-0.9	0.9	0.9	-1.0	0.7
Loneliness, isolation	2.1	2.9	5.5	-2.1	-2.3	-1.9	-1.2	-2.0	1.8	1.7	-1.1	0.0
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.5	-0.3	-0.0	0.8	-0.5	0.9	0.8	-0.9	0.5
Ever had bowel cancer screening	0.4	0.4	1.3	1.1	0.4	0.5	-1.0	0.5	-0.7	-0.6	-0.2	0.1
Diabetes diagnosed by doctor	0.8	1.3	2.8	-1.0	-1.7	-0.8	-0.8	-1.4	0.9	0.9	-1.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.2	-0.6	-1.5	-0.8	1.5	-0.8	0.6	0.7	-1.3	1.2
Friendships satisfaction	3.3	4.1	8.0	2.3	2.3	2.1	-0.5	2.8	-2.1	-2.2	1.3	-1.8
Qualifications: nursing, teaching	0.3	0.5	3.4	-0.3	-0.1	0.4	-0.3	-0.1	-0.2	-0.6	0.3	-1.8
Commuting to job workplace: Walk	2.2	2.4	4.0	1.5	2.0	1.8	0.6	1.8	-1.8	-1.7	1.3	-0.9
Eye problems/disorders: Cataract	0.2	0.2	1.3	0.2	0.1	-0.1	-0.7	-0.1	-0.1	-0.3	0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.0	-0.4	-1.0	-0.5	-0.0	-0.6	0.7	0.7	-1.7	0.1
Medication for cholesterol	4.1	6.2	10.3	3.2	2.7	2.1	0.4	2.7	-2.8	-2.7	2.9	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.3	-0.9	-1.5	-1.4	-0.1	-1.8	0.8	0.8	-0.6	0.4
Back pain experienced in last month	0.5	0.8	1.4	0.4	0.8	1.1	1.1	0.9	-1.1	-1.2	0.7	-0.1
Mineral and other dietary supplements	0.3	0.4	1.7	-0.3	0.2	0.8	-1.0	0.1	-0.2	-0.3	-1.3	0.2
Breast cancer (self-reported)	5.5	6.6	9.7	2.5	3.0	2.4	-1.1	2.8	-3.0	-3.1	1.7	-2.6
Asthma (self-reported)	1.6	3.1	6.0	1.6	1.5	1.1	1.1	1.3	-1.8	-2.0	2.5	-2.4
Osteoporosis (self-reported)	1.0	1.2	2.3	-0.9	-1.4	-1.1	-0.2	-1.5	1.5	1.4	-0.5	-0.2
Osteoarthritis (self-reported)	1.0	1.3	4.3	-0.9	-0.8	-0.1	-0.8	-1.3	1.2	1.1	-2.1	1.0
Medication: Aspirin	2.4	3.2	5.9	-1.9	-2.1	-2.4	-0.5	-1.6	2.1	1.9	-1.8	0.4
Medication: Gliclazide	1.7	2.0	4.4	-0.6	-2.1	-0.8	0.0	-1.7	1.5	1.6	-1.3	1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	1.1	0.9	0.7	-0.3	0.6	-0.9	-0.7	1.2	0.4
Smoking status: Current	0.9	1.4	3.2	-1.6	-1.8	-1.0	-0.4	-1.2	1.3	1.2	-1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	3.7	1.7	1.8	1.3	0.1	1.9	-1.7	-1.6	1.2	-1.5
Whole body water mass	0.1	0.6	2.6	-0.1	0.6	1.3	1.6	0.6	-0.1	-0.2	0.3	0.5
Leg predicted mass (right)	0.3	1.5	5.3	0.5	1.2	1.8	2.3	1.1	-0.6	-0.7	0.6	0.6
Arm fat mass (left)	0.8	3.1	7.7	1.1	1.8	2.8	2.7	1.4	-1.3	-1.2	0.8	1.8
Number of self-reported non-cancer illnesses	1.5	2.6	4.7	-2.0	-1.9	-1.1	0.1	-1.7	2.2	2.0	-1.8	0.0
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.5	-0.7	-0.6	-0.7	-0.9	0.8	0.9	-1.3	0.5
Miserableness	0.7	1.1	2.0	1.2	1.0	1.4	-0.7	1.1	-1.4	-1.4	0.4	-0.4
Guilty feelings	0.7	1.1	2.0	-1.0	-1.4	-0.7	0.8	-1.0	1.2	1.2	-1.3	-0.6
Wears glasses or contact lenses	1.0	1.1	2.1	-0.7	-0.8	-0.8	0.1	-1.0	1.3	1.4	-1.4	1.3
Ever taken oral contraceptive pill	0.2	0.3	1.5	0.2	0.1	0.5	1.2	0.5	-0.4	-0.3	-0.2	-0.2
Hearing aid user	0.9	1.1	2.0	0.6	1.1	1.2	1.4	1.2	-1.0	-0.9	1.1	-0.4
Mother’s age at death	1.8	2.2	4.8	1.5	1.3	0.7	0.4	1.1	-1.5	-1.7	2.0	-2.2
Financial situation satisfaction	1.4	1.7	3.9	2.0	1.1	1.4	-0.8	1.4	-1.5	-1.5	0.6	-1.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.3	-1.0	-1.2	-0.5	-0.9	-1.2	0.7	0.8	-1.0	1.8
Commuting to job workplace: Public transport	1.1	1.3	2.7	1.1	1.2	0.8	-0.1	1.6	-1.2	-1.2	1.5	-0.8
Eye problems/disorders: Glaucoma	0.8	0.9	1.7	-1.0	-0.7	-0.9	0.8	-1.3	1.2	1.2	0.3	0.5
Medication: Blood pressure	6.1	11.6	21.7	-4.7	-3.8	-2.2	-1.6	-4.2	4.0	3.6	-3.4	1.8
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.5	1.1	0.0	1.6	-1.9	0.6	-0.5	-0.6	-1.3	0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.8	0.7	0.3	-0.7	0.7	0.5	-0.5	-0.5	2.0	-1.5
High cholesterol (Self-reported)	0.6	1.0	4.5	-0.6	-0.5	-0.3	-2.1	-0.3	0.4	0.4	-1.8	0.7
Medication: Bendroflumethiazide	3.0	4.6	7.2	-2.4	-2.2	-1.8	-1.1	-2.5	2.7	2.7	-1.6	1.7
Medication: Paracetamol	0.1	0.1	0.6	0.2	0.3	0.2	-0.1	0.0	-0.0	0.0	-0.8	0.5
Medication: Lisinopril	6.4	8.3	12.2	-3.1	-3.2	-2.7	-2.6	-3.2	3.0	2.8	-3.5	1.2
Medication: Atorvastatin	0.1	0.2	0.7	0.1	0.4	0.8	0.4	0.5	-0.2	-0.2	0.2	0.5
Illnesses of father: High blood pressure	0.9	1.1	2.5	-0.9	-1.6	-0.6	-0.0	-1.6	1.2	1.3	-0.5	0.8
Alcohol drinker status: Never	0.7	0.8	2.8	-0.7	-0.1	-0.7	-1.3	-0.6	0.9	0.6	-0.7	-1.7
Ever smoked	2.0	3.5	6.1	-2.5	-2.2	-2.3	1.6	-1.8	2.1	1.9	-1.1	0.3
Basal metabolic rate	0.2	0.9	3.9	0.2	0.7	1.5	2.0	0.7	-0.3	-0.3	0.5	0.7
Leg fat percentage (left)	0.7	2.5	6.5	1.0	1.5	2.6	2.0	1.5	-1.5	-1.5	0.9	0.8
Arm fat-free mass (left)	0.1	0.4	1.8	-0.1	0.5	1.3	1.2	0.5	-0.2	-0.2	0.2	0.3
Number of operations (self-reported)	1.8	2.7	4.9	-1.9	-1.9	-1.4	-0.6	-2.2	2.0	1.9	-1.0	1.1
Average weekly beer plus cider intake	0.6	0.9	3.1	-1.2	-1.3	-0.3	0.0	-1.8	1.0	0.7	-0.0	-0.4
Irritability	0.1	0.2	1.4	0.4	0.2	-0.1	0.3	-0.0	0.4	0.3	-1.2	0.4
Risk taking	0.1	0.2	0.5	-0.2	-0.4	-0.5	0.2	-0.1	0.6	0.7	-0.2	-0.2
Ever had prostate specific antigen (PSA) test	2.4	2.7	4.7	-2.1	-2.0	-1.5	0.7	-2.2	2.0	2.1	-0.1	0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.8	0.0	0.1	-0.3	-0.9	-0.2	0.2	0.3	0.3	0.3
Age started oral contraceptive pill	0.2	0.3	0.9	-0.5	-0.3	-0.2	-0.1	0.0	0.7	0.6	0.9	-0.8
Diastolic blood pressure, automated reading	0.9	2.9	4.6	-2.1	-1.8	-0.8	-0.0	-2.0	2.1	2.0	-2.0	0.9
Ever depressed for a whole week	0.6	0.7	1.3	1.1	1.1	1.1	0.7	1.1	-0.5	-0.3	-0.4	0.5
Unable to work because of sickness or disability	0.2	0.3	0.9	-1.0	-0.3	-0.1	0.3	-0.1	0.8	0.8	-0.2	-0.1
Commuting to job workplace: Cycle	0.2	0.3	1.5	-0.1	0.2	-0.1	0.6	-0.3	0.3	0.6	0.3	1.2
Myopia	2.5	3.6	7.9	1.7	2.0	2.0	0.5	2.1	-1.7	-1.6	2.8	-1.9
Vascular/heart problems diagnosed by doctor	7.6	20.8	31.7	5.6	5.3	4.0	2.0	5.4	-5.5	-5.2	3.9	-2.4
Cholesterol lowering medication	0.2	0.3	0.4	0.1	0.5	0.7	-0.6	0.2	-0.5	-0.6	-0.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	-0.4	-0.7	0.7	-0.8	-0.7	0.7	0.7	-1.6	1.3
Pain experienced in last month	0.1	0.1	0.4	0.1	0.5	0.2	0.1	0.4	-0.3	-0.1	0.7	0.3
Supplements: Calcium	3.4	3.7	7.6	2.8	1.9	2.1	1.7	1.9	-1.6	-1.7	1.7	-1.6
Basal cell carcinoma (self-reported)	1.7	2.0	4.7	1.4	1.7	1.6	2.2	1.5	-1.2	-1.1	0.9	-0.8
Heart attack/myocardial infarction (self-reported)	1.6	2.0	3.6	-1.8	-1.6	-1.2	-1.0	-1.0	1.8	1.5	-1.9	0.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	4.8	-2.2	-2.2	-2.0	-0.6	-1.4	1.9	1.8	-1.2	1.3
Heart disease (siblings)	0.6	0.8	1.6	-0.4	-0.9	-1.1	-0.7	-1.0	0.9	0.8	-1.3	0.4
Alcohol drinker status: Previous	0.2	0.2	1.2	0.0	0.0	0.3	0.5	0.3	-0.2	-0.1	1.1	0.0
Pack years of smoking	0.0	0.1	0.4	0.1	-0.2	0.2	0.1	0.0	-0.2	-0.2	0.6	-0.0
Impedance of whole body	0.6	2.9	6.9	2.6	1.6	0.9	-0.7	1.9	-2.1	-1.8	1.8	-0.8
Leg fat mass (left)	0.6	2.2	6.5	0.8	1.4	2.3	2.5	1.3	-1.1	-1.1	0.8	1.1
Arm predicted mass (left)	0.1	0.5	2.6	-0.1	0.5	1.2	1.6	0.5	-0.0	-0.1	0.0	0.5