Hub : Genes

PDXK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1350	0.0440	2.4e-05	0.107	NA	0.100	NA	0.116	1.8e-06	NA	3.8e-06	NA	6.2e-07
2	GTEx	Cells Transformed fibroblasts	0.1130	0.0470	8.8e-03	-0.002	NA	0.037	NA	0.004	4.5e-01	NA	8.7e-04	NA	1.4e-01
3	GTEx	Esophagus Mucosa	0.2870	0.0640	3.6e-12	0.176	NA	0.240	NA	0.235	7.1e-12	NA	4.2e-16	NA	8.4e-16
4	GTEx	Heart Left Ventricle	0.2068	0.0615	4.0e-04	-0.003	NA	0.032	NA	0.002	5.4e-01	NA	8.0e-03	NA	2.3e-01
5	GTEx	Liver	0.1770	0.0760	6.1e-03	0.041	NA	0.034	NA	0.051	2.7e-02	NA	4.1e-02	NA	1.5e-02
6	GTEx	Lung	0.1387	0.0529	3.8e-04	0.041	NA	0.042	NA	0.045	4.0e-04	NA	3.5e-04	NA	2.3e-04
7	GTEx	Muscle Skeletal	0.0623	0.0275	2.6e-03	0.018	NA	0.002	NA	0.006	6.3e-03	NA	1.7e-01	NA	8.3e-02
8	GTEx	Vagina	0.2310	0.0780	7.2e-04	0.193	NA	0.205	NA	0.230	3.4e-05	NA	1.9e-05	NA	5.2e-06
9	NTR	Blood	0.0741	0.0209	4.6e-08	0.054	0.028	0.048	0.048	0.052	7.3e-17	2.2e-09	3.1e-15	3.8e-15	2.2e-16
10	TCGA	Lung Squamous Cell Carcinoma	0.0414	0.0214	8.6e-03	-0.002	0.010	0.000	NA	-0.001	8.3e-01	2.4e-02	3.1e-01	NA	3.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.8	2.8	5.7	1.7	-0.3	2.1	-0.9	2.4	1.9	2.3	1.4	1.1	-1.5
Bipolar Disorder or Schizophrenia	1.6	3.9	8.2	2.5	-0.1	2.3	-1.2	2.9	1.9	2.6	2.5	0.7	-0.9
Depressed Affect (Nagel 2018)	0.2	0.5	2.6	-0.1	-1.6	-0.2	1.1	-0.0	0.4	-0.0	-0.0	-0.8	0.7
Depression (Nagel 2018)	0.3	0.5	1.5	0.6	0.2	0.2	1.2	0.7	0.6	0.7	1.1	-0.5	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.7	0.1	1.5	0.4	-0.7	0.5	-0.2	-0.7	-0.1	0.7	-1.6
Neuroticism (Nagel 2018)	0.6	1.4	6.9	0.5	-2.6	0.7	1.7	0.4	1.0	0.5	0.8	-1.0	0.5
Schizophrenia (2018)	0.8	1.6	4.6	1.8	0.2	1.2	-0.8	1.7	0.8	1.4	2.2	-0.1	0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	0.8	0.1	0.3	-0.0	0.5	1.0	-0.1	1.0	-0.1	0.4
Worry (Nagel 2018)	0.5	1.0	3.8	0.8	-1.9	1.1	0.6	0.4	1.4	0.7	0.8	-0.5	0.8
Alzheimer’s Disease (in mother)	1.4	1.7	5.2	-0.4	-1.7	-0.6	2.2	-0.6	1.0	-0.4	-0.3	-2.3	1.2
Alzheimer’s Disease (in father)	0.7	0.8	2.4	0.9	0.2	0.6	-0.3	1.2	0.8	0.8	1.1	-0.6	-1.5
Alzheimer’s Disease (including proxy)	0.7	0.9	4.0	0.1	-0.9	-0.2	1.6	0.2	1.3	0.1	0.1	-2.0	0.6
Crohns Disease (2017)	0.9	1.9	5.2	-1.8	0.0	-1.4	1.1	-1.1	-1.5	-2.3	-1.9	0.3	0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.9	-0.2	0.1	-0.5	1.0	0.3	-0.1	-1.4	-0.5	0.3	-0.1
Ulcerative Colitis (UC)	0.4	0.7	1.8	1.2	0.1	0.7	1.1	1.2	1.3	-0.2	0.9	0.1	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.0	3.9	8.6	2.9	-1.0	2.0	0.9	2.8	1.8	2.0	2.5	-0.0	-1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.1	0.1	1.5	0.2	0.4	0.2	-0.5	-1.1	0.0	1.0	-1.3
Breast Cancer	3.1	7.6	12.7	-3.3	1.4	-2.5	0.8	-3.3	-3.3	-3.4	-3.6	-0.6	3.1
Ovarian Cancer	0.4	0.5	2.8	-0.3	-0.4	0.0	1.7	-0.6	0.2	-0.8	-0.6	-0.3	0.3
Prostate Cancer	0.3	0.4	1.4	0.4	1.0	0.1	-1.2	0.3	-0.8	0.3	0.4	-0.3	0.1
Age at First Birth	0.6	0.8	3.6	-0.3	-0.0	-0.6	1.9	-0.9	-0.1	0.2	-0.1	0.4	1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	3.8	5.2	10.4	-3.2	-0.1	-2.5	-0.2	-3.0	-1.9	-1.9	-2.7	-1.6	3.0
Coronary Artery Disease (CAD)	3.9	4.7	9.9	-3.0	-0.5	-2.1	-0.0	-2.5	-2.2	-2.8	-3.1	-0.8	1.9
Crohns Disease (2012)	1.8	2.9	7.9	-2.4	-0.2	-1.8	0.3	-1.7	-1.4	-2.8	-2.4	-0.4	0.9
Mean Putamen Volume	1.7	1.9	4.4	1.6	0.4	2.1	-0.2	1.5	2.0	1.6	1.4	1.2	-0.3
Fasting Glucose	0.3	0.4	1.9	0.6	1.4	0.2	-0.7	0.9	-0.3	0.0	0.3	0.0	-0.2
HbA1C	2.0	2.2	3.5	1.4	-1.6	1.7	-1.0	1.7	1.5	1.8	1.1	-0.9	-1.9
HDL Cholesterol	0.8	1.3	3.9	1.3	-0.9	2.0	0.2	0.7	1.8	0.5	1.0	0.6	-0.8
LDL Cholesterol	1.3	2.1	6.0	1.4	-0.0	1.6	-1.0	1.9	0.1	2.5	1.6	-0.4	-1.8
Lupus	0.2	0.3	1.6	-0.7	-0.4	-0.2	-0.0	-0.8	-0.2	-0.4	-0.2	0.1	1.3
Neuroticism (2016)	0.4	0.5	1.7	-0.8	-1.3	0.2	-0.4	-1.1	0.2	-0.5	-1.1	0.0	0.2
Primary Biliary Cirrhosis	1.0	1.4	2.8	1.5	-0.4	0.9	0.7	1.7	1.4	1.3	1.1	-0.2	-1.6
Rheumatoid Arthritis	0.3	0.4	1.5	-0.7	-0.2	-1.2	-0.5	-0.5	0.4	-0.3	-0.6	0.4	0.6
Schizophrenia (2014)	0.8	1.8	4.8	1.9	0.2	1.3	-1.0	1.9	0.9	1.5	2.2	0.3	0.4
Triglycerides	0.8	1.2	2.7	-1.4	0.3	-1.2	-1.3	-1.6	-1.3	-1.1	-1.1	0.6	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.1	-0.2	0.5	0.5	0.3	0.7	-0.0	-0.2	0.5	-0.8
Ulcerative Colitis	1.3	1.8	3.9	1.7	-1.8	1.0	2.0	1.4	1.7	-0.2	1.4	-0.2	-0.8
Blood Eosinophil Count	2.3	17.4	31.9	-4.9	2.4	-5.4	2.9	-4.2	-3.9	-3.8	-4.8	-2.3	5.6
Blood Platelet Count	0.0	0.5	1.3	-0.8	1.1	-0.4	-0.6	-0.8	-0.6	-0.7	-0.5	1.1	-0.3
Blood Red Count	1.7	16.6	32.1	-4.9	2.1	-5.7	-0.1	-5.1	-4.7	-5.1	-4.8	-1.2	2.6
Blood White Count	0.3	1.9	3.3	-1.4	1.4	-1.4	-0.2	-1.5	-1.5	-1.5	-1.8	0.7	1.3
Heel T-Score	0.2	1.2	2.0	-1.4	1.0	-1.3	0.3	-1.0	-0.4	-1.4	-1.4	0.8	1.2
BMI	0.1	0.5	2.7	-0.8	-0.8	-0.3	1.6	-0.4	-0.0	-0.1	-0.3	0.3	0.0
Height	0.1	1.6	5.8	0.7	-1.1	1.1	-1.7	0.7	1.7	2.4	0.6	0.5	0.3
Waist Hip Ratio (WHR)	0.8	3.8	6.5	-2.2	2.5	-2.4	-0.1	-1.9	-1.9	-1.7	-2.2	-1.8	1.7
Systolic Blood Pressure	4.4	21.9	41.7	-6.1	1.0	-6.5	-0.6	-4.9	-5.5	-5.6	-5.8	-3.0	3.3
Smoking Status	2.4	5.7	10.6	-3.1	0.9	-2.5	1.7	-2.5	-2.5	-2.6	-3.2	-1.2	2.5
Allergy or Eczema	3.0	8.0	17.5	4.1	0.2	2.6	-0.4	3.7	3.0	3.6	4.2	-0.4	-1.6
Cardiovascular Disease	4.3	14.1	27.4	-5.2	1.6	-5.1	-0.5	-3.4	-4.1	-4.8	-5.2	-1.0	2.2
Hypothyroidism (self reported)	0.2	0.5	0.9	-0.9	-0.9	-0.4	-0.3	-1.0	-0.9	-0.5	-0.8	-0.1	0.4
Respiratory disease	0.9	2.0	4.9	1.6	0.4	1.0	0.0	1.8	2.0	1.7	2.2	-0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-0.7	0.5	-0.3	0.7	-0.2	-0.9	-1.1	-0.8	1.2	-1.2
Lung FEV1/FVC ratio	0.6	3.2	11.5	2.0	-1.2	1.6	-0.8	1.9	0.8	1.4	2.3	0.3	-3.4
Lung FVC	0.1	0.5	1.4	0.4	0.2	0.4	1.1	0.3	-0.7	-0.4	0.0	-1.2	-0.9
Neuroticism	0.3	0.7	2.8	0.6	-1.7	0.8	1.3	0.3	0.8	0.4	0.9	-0.1	0.4
Chronotype (morning person)	0.5	1.2	2.8	-1.2	0.5	-1.3	0.5	-1.3	-1.6	-1.7	-1.0	0.7	0.4
Hair Pigment	0.1	3.3	19.5	0.8	-4.4	2.5	1.8	-0.6	1.3	0.7	1.0	0.3	-0.3
Tanning	0.3	3.9	9.8	-2.2	-0.5	-3.1	0.5	-2.6	-1.9	-2.9	-2.1	-0.3	0.7
Hand grip strength (left)	0.3	0.9	2.5	-0.1	-0.5	0.7	-1.6	0.1	0.2	1.4	0.0	-1.1	1.6
Number of treatments/medications taken	1.5	2.6	8.2	-1.7	-0.3	-2.9	1.9	-1.6	-1.4	-1.6	-1.3	-1.0	1.3
Average weekly spirits intake	0.9	1.1	4.3	0.8	-2.1	0.3	0.8	0.8	2.0	0.6	0.2	-0.1	-0.3
Sensitivity / hurt feelings	0.9	1.6	8.0	-0.9	-0.6	-0.2	2.8	-1.2	-1.1	-1.0	-0.7	-1.0	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	0.4	-0.1	0.7	1.1	0.5	0.2	0.7	0.8	-0.1	-1.1
Hearing difficulty/problems: Yes	0.9	1.4	3.9	-2.0	-0.3	-0.1	-0.3	-1.9	-1.3	-0.7	-1.7	1.2	0.5
Relative age of first facial hair	1.3	2.6	6.8	-1.8	1.9	-0.7	-0.8	-2.5	-2.6	-1.5	-1.3	1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	0.5	-0.5	-0.1	0.5	0.4	0.6	0.7	0.6	0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	4.1	-0.3	0.6	-0.5	1.1	-0.4	0.4	0.6	-0.0	-2.0	2.0
Ever had hysterectomy (womb removed)	0.9	1.0	3.3	-0.8	0.8	-1.4	0.8	-0.8	0.4	-0.7	-0.5	1.1	1.8
Systolic blood pressure, automated reading	1.3	3.9	10.2	-2.5	-0.7	-3.2	0.2	-1.8	-1.6	-2.4	-2.3	-2.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.2	-0.8	-0.4	-0.2	-0.5	-0.6	-0.7	-0.8	-1.5	0.3	-1.0
Angina	2.5	3.3	8.3	-2.3	0.9	-2.9	1.4	-1.7	-1.2	-2.1	-2.0	-0.7	2.0
Medication for hormone replacement therapy	2.4	2.6	6.8	-1.6	0.2	-1.7	1.0	-2.0	-1.7	-0.9	-1.2	-2.0	2.6
Vitamin and mineral supplements	1.9	2.6	6.9	-1.3	2.6	-1.8	-1.0	-1.1	-2.4	-1.8	-1.1	-1.1	0.4
Supplements: Zinc	0.8	0.8	3.9	-0.1	-0.5	1.0	0.7	0.5	1.4	0.4	-0.2	2.0	0.5
Medication: Co-codamol	0.8	0.9	1.9	-1.2	0.6	-1.2	-0.3	-1.4	-0.7	-0.7	-1.3	1.2	0.3
Medication: Metformin	2.1	3.0	7.0	-2.1	1.4	-2.2	0.8	-1.5	-2.0	-2.6	-2.1	-0.5	0.3
Diabetes (father)	0.3	0.3	1.8	-0.5	-0.5	0.2	-0.2	-0.2	-0.6	-0.2	-0.7	0.4	-1.3
Diabetes (mother)	0.8	1.0	3.6	0.6	-1.9	1.5	0.9	0.4	1.3	0.6	0.7	0.3	0.3
Severe depression (siblings)	0.7	0.8	2.6	-0.8	0.8	-1.3	-0.4	-0.9	-0.6	-1.6	-1.0	0.3	-0.3
Pack years adult smoking proportion	0.3	0.4	2.1	0.7	0.5	0.1	0.2	0.5	1.4	-0.0	0.1	0.3	1.0
Impedance of leg (right)	0.2	0.8	2.7	1.6	0.1	0.6	0.1	1.0	0.9	0.4	1.0	-0.1	-1.3
Leg fat-free mass (left)	0.3	1.4	4.1	0.5	-2.0	1.5	0.6	0.9	1.1	1.6	0.9	1.4	-0.3
Trunk fat percentage	1.2	4.7	7.8	2.2	-2.7	2.1	2.4	2.0	2.8	1.9	2.4	1.0	-1.5
Hand grip strength (right)	0.2	0.6	2.7	-0.3	-0.1	0.5	-1.7	0.1	0.0	0.6	-0.5	-1.2	1.0
Townsend deprivation index at recruitment	0.3	0.4	2.1	-0.3	1.5	0.1	0.2	-0.4	-0.9	-0.3	-0.3	-0.4	0.1
Current tobacco smoking	1.2	2.0	5.2	-1.2	-0.7	-1.3	0.6	-1.1	-0.9	-1.6	-1.3	-2.3	2.1
Average weekly fortified wine intake	0.6	0.7	2.4	0.4	-0.9	1.2	-0.8	0.6	0.7	0.4	0.3	-1.6	-0.3
Maternal smoking around birth	0.7	1.0	2.5	-1.1	1.4	-0.4	-1.6	-1.0	-0.6	-0.6	-1.1	0.3	0.8
Fed-up feelings	0.3	0.6	2.3	-0.3	-1.3	0.5	1.5	-0.3	-0.1	-0.4	-0.3	0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	0.6	0.1	1.0	0.7	0.7	0.7	1.1	0.9	0.8	0.4
Relative age voice broke	1.5	2.2	5.2	1.7	0.9	1.6	-0.7	1.6	0.9	1.7	2.3	1.6	-1.2
Taking other prescription medications	0.4	0.6	2.4	-0.4	-0.5	-0.9	1.6	-0.3	-0.4	0.2	0.0	-0.7	1.1
Age when periods started (menarche)	0.3	0.7	2.0	-0.4	-1.4	-0.4	-1.2	-0.6	0.9	-0.8	-0.8	0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	0.1	-0.2	-0.6	0.3	0.3	0.6	0.5	0.1	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.9	-1.3	1.1	0.1	-0.8	-1.2	-1.1	-0.3	-1.3	-0.1	1.4
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	4.2	-0.2	1.3	0.1	-1.6	0.2	-0.4	0.2	-0.1	-2.1	1.2
Qualifications: CSEs or equivalent	1.8	2.4	6.3	2.5	-1.0	1.4	0.4	2.0	2.1	1.5	1.9	0.2	0.1
Serious illness, injury or assault to yourself	0.8	1.0	2.5	1.0	-0.6	1.0	1.5	1.2	0.9	1.6	0.7	0.5	-0.1
High blood pressure	4.9	13.7	29.1	-5.4	0.4	-5.1	-1.0	-3.9	-3.7	-4.3	-5.3	-0.3	2.3
Hayfever, allergic rhinitis or eczema	3.2	7.0	16.9	3.8	0.6	2.1	-1.0	3.7	2.6	3.4	4.1	-0.4	-0.9
Multivitamins +/- minerals	0.9	1.1	2.4	1.1	-1.5	1.0	1.3	0.8	1.5	0.5	0.5	1.2	0.3
Stomach or abdominal pain in last month	0.8	1.0	2.5	0.9	-1.2	1.1	-0.2	1.3	1.6	1.2	0.8	0.6	-0.2
Supplements: Glucosamine	0.4	0.5	1.0	-1.0	1.0	-0.1	-0.7	-0.8	-0.7	0.5	-0.8	0.5	0.7
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.2	-1.3	-0.3	-1.9	0.4	-0.3	-1.4	-1.2	-1.4	-2.0	-0.2
Medication: Atenolol	3.3	4.2	7.4	-2.4	1.6	-2.7	-0.4	-2.2	-2.6	-2.4	-2.5	0.3	1.6
Medication: Levothyroxine sodium	0.1	0.1	0.4	-0.1	-0.6	0.3	0.3	-0.2	-0.0	0.1	-0.4	0.3	-0.3
Sitting height	0.9	6.6	15.7	2.6	-2.0	3.5	-0.4	2.8	2.9	4.0	3.0	0.0	-1.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.2	0.1	-0.0	0.3	0.3	0.1	0.1	0.4	-0.2	-0.0
High blood pressure (mother)	1.1	1.5	3.1	-1.3	-1.3	-1.0	1.4	-1.2	-1.8	-1.2	-1.0	-1.4	-0.1
Body mass index (BMI)	0.3	1.2	3.9	0.5	-1.7	1.0	2.0	0.8	1.2	0.8	0.8	0.9	-0.2
Impedance of leg (left)	0.2	0.9	2.9	1.7	-0.3	0.7	0.1	1.1	1.4	0.5	1.0	0.1	-1.0
Leg predicted mass (left)	0.3	1.5	4.0	0.5	-2.0	1.6	0.6	0.9	1.1	1.6	1.0	1.4	-0.4
Trunk fat mass	0.9	4.1	7.1	1.8	-2.7	2.1	2.2	1.9	2.7	1.9	2.0	1.2	-1.1
Waist circumference	0.4	1.3	3.7	0.5	-1.7	0.9	1.9	1.0	1.5	1.2	0.6	0.3	-0.5
Number of incorrect matches in round	0.3	0.6	1.6	-0.9	-0.1	-0.6	-0.3	-1.2	-0.1	-0.6	-1.3	-0.2	0.9
Past tobacco smoking	2.8	5.2	9.6	2.8	-2.7	2.0	-0.6	2.1	3.0	2.6	3.1	-0.7	-1.4
Alcohol usually taken with meals	0.3	0.5	2.3	0.8	-1.5	0.4	0.0	0.2	0.9	1.0	0.4	-0.6	0.4
Nervous feelings	0.3	0.6	1.4	0.7	-0.3	1.2	-0.2	0.5	0.7	0.8	1.2	0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	5.1	0.1	-0.5	0.6	2.3	0.3	0.3	0.8	0.7	-0.9	0.7
Hearing difficulty/problems with background noise	1.5	2.4	6.5	-2.6	-0.8	-0.9	0.9	-2.3	-1.8	-0.9	-1.9	-1.0	0.8
Hair/balding pattern: Pattern 2	1.3	1.6	7.8	0.6	-1.9	1.0	-0.3	0.7	-0.2	1.2	1.0	0.4	-2.8
Had menopause	0.8	1.0	2.9	0.9	-0.0	0.2	1.1	0.8	1.7	0.8	0.8	-1.6	0.7
Had other major operations	0.0	0.0	0.3	-0.1	-0.2	-0.0	-0.5	0.1	-0.1	0.2	-0.0	0.2	-0.0
Forced vital capacity (FVC)	0.5	1.9	5.5	1.6	-1.0	2.3	-0.2	1.5	0.7	1.8	1.2	-0.6	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.0	-1.1	1.1	0.3	-0.4	-1.0	-0.6	-0.2	-0.9	0.6	1.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	1.2	-0.3	1.2	1.4	0.8	0.8	0.6	1.2	-1.0	-1.5
Qualifications: None of the above	0.8	1.7	4.8	-1.6	1.2	-2.2	-0.2	-1.5	-0.7	-1.4	-1.5	-0.3	1.2
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.1	-0.2	-0.5	-0.9	-0.1	0.4	-0.7	-0.3	1.0	-1.1
Mouth/teeth dental problems	0.2	0.3	1.2	0.1	-1.1	0.3	-0.7	-0.4	-0.3	0.6	0.3	-0.1	-0.9
Heart attack	1.7	2.2	4.8	-1.9	0.7	-2.1	-0.1	-1.7	-0.7	-2.2	-1.6	0.5	1.5
Allergy	1.8	4.2	9.5	-2.7	-0.5	-1.4	1.3	-2.9	-1.9	-2.9	-3.1	0.5	-0.5
Pain all over the body in last month	0.2	0.2	0.7	-0.4	0.4	-0.6	0.5	-0.3	-0.9	0.0	0.4	-0.4	0.3
Diabetes (self-reported)	2.1	3.2	6.9	-2.5	0.8	-2.3	1.4	-1.7	-2.2	-1.8	-2.6	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	5.3	7.0	15.7	3.4	-0.8	2.6	-0.2	3.5	2.2	4.0	3.9	-1.6	-0.9
Medication: Ramipril	3.3	4.2	9.7	-2.8	-0.9	-3.1	0.9	-2.5	-1.7	-2.4	-2.1	-0.3	2.1
Medication: Simvastatin	1.7	2.4	4.4	-2.0	-0.8	-2.0	1.2	-1.8	-1.6	-2.1	-1.9	-0.3	0.1
Fluid intelligence score	0.3	0.7	1.9	0.0	1.1	-0.6	0.2	0.0	-1.4	-1.0	-0.1	-0.7	-1.3
Illnesses of siblings	2.3	3.2	6.2	2.2	0.5	2.5	-0.0	2.1	1.3	2.3	2.3	1.1	-1.8
Neuroticism score	0.4	0.9	2.0	0.9	-1.4	1.4	0.6	0.6	1.2	0.7	1.1	0.4	-0.0
Weight	0.4	2.0	5.2	0.8	-2.3	1.5	1.4	1.2	1.8	1.7	1.1	1.1	-0.3
Impedance of arm (right)	0.7	3.3	8.8	3.0	-0.6	1.8	0.0	2.0	2.0	1.7	2.7	0.2	-1.4
Arm fat percentage (right)	0.8	3.1	5.8	1.6	-2.2	1.8	2.4	1.6	2.2	1.4	1.8	1.4	-0.9
Trunk fat-free mass	0.1	0.4	1.7	-0.6	-1.3	0.6	0.1	0.2	0.3	1.0	-0.3	0.5	0.4
Hip circumference	1.2	5.0	9.5	1.7	-3.1	2.9	1.3	2.1	2.7	2.3	1.8	2.2	-1.7
Time employed in main current job	2.8	3.2	6.9	-2.6	0.8	-1.8	-0.7	-2.4	-1.8	-1.6	-2.1	-0.6	2.0
Alcohol intake versus 10 years previously	5.3	7.9	18.0	-3.8	0.0	-4.2	1.7	-3.5	-3.2	-2.9	-3.3	-0.8	1.1
Father’s age at death	0.7	0.9	3.2	1.0	-0.5	0.8	-0.5	0.4	-0.0	1.8	1.0	-0.4	-1.6
Worrier / anxious feelings	0.2	0.4	1.1	0.4	-0.6	1.0	0.5	0.2	1.1	0.7	0.5	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.7	0.8	0.1	0.7	-0.3	-0.3	0.2	-0.6	0.3	0.3
Falls in the last year	1.0	1.4	3.6	-1.3	-1.6	-1.4	0.6	-1.9	0.1	-1.4	-0.9	-0.2	0.6
Hair/balding pattern: Pattern 3	0.6	0.9	4.2	-1.0	-0.5	-1.1	0.0	-0.8	-0.8	-2.1	-1.1	-0.1	0.3
Number of live births	0.3	0.4	1.3	-0.4	0.6	-0.5	-1.0	-0.2	-1.1	0.1	-0.1	0.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	7.8	2.0	-0.9	2.7	-0.5	2.0	0.8	1.8	1.6	-0.2	-2.8
Pulse rate	1.0	1.6	4.7	-0.9	2.1	-1.5	1.5	-0.9	-2.2	-1.0	-0.8	-0.2	-0.1
Happiness	2.9	3.6	7.3	2.4	0.0	2.2	-1.2	1.9	1.8	2.3	2.7	1.6	-1.4
Noisy workplace	0.2	0.3	0.8	0.3	-0.3	0.4	0.6	0.1	0.8	0.6	0.5	-0.9	-0.2
Qualifications: A levels/AS levels or equivalent	2.4	5.2	11.4	3.0	-0.7	2.5	-0.5	2.4	2.6	1.7	3.4	1.6	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	2.0	0.7	-1.2	1.4	0.7	-0.1	0.6	1.0	0.8	0.4	-0.2
Mouth/teeth dental problems: Dentures	3.9	6.6	12.1	-2.9	2.0	-3.5	1.6	-2.3	-2.1	-3.1	-3.1	-1.4	2.8
Asthma	1.0	2.0	4.2	1.6	0.8	1.6	-0.6	2.0	1.8	1.8	1.6	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.9	0.3	-0.6	-0.9	2.0	-0.1	0.1	-0.9	0.4	-1.2	0.1
Medication: Cholesterol lowering	3.0	4.7	8.1	-2.9	-0.4	-2.8	1.6	-2.8	-1.4	-2.5	-2.6	-0.4	2.4
Depression (self-reported)	0.7	0.8	2.1	0.9	-1.5	1.3	1.1	0.5	-0.1	0.9	0.8	-0.7	0.2
Medication: Lansoprazole	2.2	2.5	6.1	-1.6	2.2	-2.2	-0.5	-1.3	-0.6	-1.6	-1.2	0.5	2.5
Prospective memory result	0.6	0.8	2.3	-1.4	-0.5	-1.1	0.1	-0.8	0.4	-0.8	-1.5	0.3	0.2
Lung cancer (father)	1.2	1.4	4.0	-0.9	0.4	-1.8	1.8	-0.6	-0.8	-0.8	-0.5	-2.0	1.2
Illnesses of mother	3.8	4.7	6.7	2.5	1.7	2.5	-1.5	2.6	1.2	2.2	2.5	2.0	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	10.9	3.1	-2.3	3.3	0.7	2.8	1.8	2.7	2.5	-0.3	-3.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.1	-0.9	-0.7	-0.6	0.8	-0.7	0.1	-0.6	-0.9	-0.9	1.4
Impedance of arm (left)	0.6	2.8	7.1	2.7	-0.4	1.8	0.1	1.6	1.9	1.4	2.3	0.9	-1.8
Arm fat mass (right)	0.5	2.2	4.2	1.1	-2.1	1.4	2.0	1.3	1.7	1.4	1.3	1.3	-0.6
Trunk predicted mass	0.1	0.4	1.9	-0.6	-1.4	0.6	-0.0	0.2	0.4	1.0	-0.3	0.5	0.4
Standing height	0.1	1.5	4.4	0.9	-1.5	1.3	-1.1	1.0	1.4	2.1	1.0	0.6	-0.2
Length of working week for main job	0.6	0.7	2.7	0.6	0.2	0.8	-1.6	0.4	0.2	1.5	0.4	0.7	-0.5
Exposure to tobacco smoke at home	0.6	0.7	2.5	0.1	-1.2	0.7	-0.6	-0.5	0.2	0.0	-0.2	1.6	-1.2
Breastfed as a baby	0.8	1.0	3.3	-0.6	-0.3	-0.6	1.8	-0.9	-1.1	-0.3	-0.6	-1.4	1.1
Tense / ‘highly strung’	0.7	1.2	2.7	0.9	-1.5	1.6	0.9	1.2	1.2	1.1	1.0	0.8	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.6	-1.8	0.0	-1.2	0.5	-2.1	-2.4	-1.5	-1.6	0.2	1.4
Hair/balding pattern: Pattern 4	0.4	1.0	4.4	-0.2	1.7	0.2	2.1	-0.7	-0.3	-0.9	-0.5	0.2	0.9
Birth weight of first child	0.1	0.2	0.9	-0.0	-0.0	0.4	-0.6	0.3	1.0	-0.3	-0.1	0.0	-0.6
Peak expiratory flow (PEF)	0.4	0.9	4.3	-0.3	0.6	-0.1	-1.7	0.2	-1.2	-0.1	-0.5	-0.3	-2.1
Pulse wave reflection index	0.7	0.8	2.5	-1.1	-1.1	0.2	0.1	-1.4	0.5	-0.7	-0.9	0.1	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	1.0	-0.5	0.8	0.6	0.4	1.3	0.0	0.9	0.4	-1.0
Loud music exposure frequency	1.2	1.3	8.0	-0.1	-0.3	0.4	2.8	-0.3	-0.1	-0.0	0.4	-1.9	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.8	1.1	-1.2	1.1	0.3	0.6	1.0	0.9	1.3	0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	1.1	0.7	0.9	-0.3	1.1	0.4	0.9	1.4	1.0	0.1
Blood clot in the leg (DVT)	1.5	1.9	4.6	-1.4	0.2	-1.3	-1.4	-1.2	-2.1	-1.7	-1.5	1.3	0.9
Medication: Paracetamol	0.7	1.2	3.0	1.1	0.4	1.2	0.5	1.3	1.7	1.1	1.4	0.0	0.7
Headache pain in last month	0.6	1.0	5.0	-0.1	0.8	-0.7	0.6	-0.0	-0.7	0.3	0.7	-2.2	1.5
Medication for cholesterol, blood pressure or diabetes	6.8	11.3	21.2	4.6	-0.2	4.5	-0.4	4.2	2.8	4.6	4.4	-0.5	-2.3
Glaucoma (self-reported)	0.6	0.7	2.7	-0.5	0.5	-1.6	0.4	-1.0	-0.2	-0.7	-0.2	0.2	1.6
Gout (self-reported)	0.5	0.7	2.4	-0.7	0.2	-0.6	0.8	-0.6	-0.9	-0.9	-1.5	1.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.4	-1.3	-0.4	-0.8	-0.1	-1.2	-1.5	-0.9	-1.1	-0.8	0.6
Medication: Amlodipine	1.9	2.7	5.8	-2.3	-0.9	-2.4	-0.4	-1.9	-1.7	-1.8	-2.2	0.3	0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.8	-0.7	1.3	-0.6	-1.3	-0.4	-0.9	0.3	-0.5	0.7	0.9
Birth weight	0.3	0.7	2.8	-0.2	1.5	0.1	-0.5	-0.2	-0.3	1.0	-0.1	0.3	1.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.9	-1.0	1.0	-0.6	-1.2	-1.2	-1.0	-0.7	-1.1	1.7	-0.6
High blood pressure (siblings)	4.8	7.0	15.3	-3.2	0.0	-3.9	-0.0	-3.0	-3.1	-3.5	-3.2	-0.5	1.6
Forced vital capacity (FVC), Best measure	1.1	3.9	7.9	2.4	-1.8	2.8	0.5	2.3	1.4	2.3	1.9	-0.2	-2.4
Body fat percentage	1.0	4.0	6.7	1.9	-2.6	1.9	2.5	1.8	2.6	1.6	2.1	1.1	-1.3
Leg fat percentage (right)	0.9	3.1	6.3	1.7	-2.0	1.8	2.5	1.7	2.4	1.4	1.8	0.6	-0.7
Arm fat-free mass (right)	0.1	0.5	2.4	-0.1	-1.5	0.8	0.2	0.5	0.8	1.0	0.2	0.7	0.1
Exposure to tobacco smoke outside home	0.5	0.7	2.9	0.5	-0.7	1.0	-0.2	0.4	0.4	0.9	0.4	1.7	-0.9
Comparative body size at age 10	1.9	5.3	11.0	-3.3	1.9	-1.2	-2.7	-3.0	-2.3	-1.8	-3.2	0.7	1.4
Number of full brothers	2.0	2.5	4.6	2.1	0.0	1.7	-0.4	2.0	1.6	1.8	2.2	1.5	0.7
Worry too long after embarrassment	0.5	0.9	2.8	0.4	-1.6	1.7	0.5	0.3	1.2	0.7	0.6	0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.7	-1.7	1.5	-1.2	0.4	-1.4	-1.6	-0.9	-1.6	-0.3	1.2
Wheeze or whistling in the chest in last year	0.2	0.3	1.7	-0.0	0.2	-0.4	-0.5	0.3	1.0	0.0	0.0	0.4	1.3
Number of children fathered	1.8	2.0	3.6	-1.3	-1.0	-1.4	1.0	-1.6	-1.3	-1.7	-1.9	-1.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	4.4	5.2	9.3	-2.6	-0.5	-2.0	0.8	-2.7	-3.0	-2.2	-2.5	-3.1	1.7
Age at first live birth	0.2	0.4	1.7	0.1	-1.3	0.6	0.4	-0.1	0.2	-0.0	0.1	-0.0	-1.2
Pulse wave peak to peak time	0.9	1.1	2.1	1.2	0.7	0.8	-1.2	0.9	0.1	1.0	1.1	1.2	-1.4
Health satisfaction	0.4	0.5	1.2	-0.8	0.2	-0.9	-0.7	-0.3	-0.2	-0.4	-0.8	1.1	-0.8
Shortness of breath walking on level ground	1.0	1.2	3.1	-1.7	0.2	-1.5	-0.0	-1.2	-0.2	-1.2	-1.8	0.1	0.8
Qualifications: College or University degree	0.9	3.0	7.1	1.8	-1.3	2.4	-0.8	1.7	1.1	2.0	1.8	-0.2	-2.7
Eye problems/disorders: None of the above	1.2	1.4	3.7	1.0	-0.7	1.6	1.9	1.2	0.5	1.2	1.0	-1.2	-0.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	5.0	1.5	-0.3	2.2	1.7	1.4	1.2	1.4	1.5	-0.7	-0.4
Emphysema/chronic bronchitis	0.4	0.4	1.9	-0.1	-1.4	-0.6	1.1	-0.1	-0.1	0.1	0.3	-0.7	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.8	1.9	0.6	-1.0	1.1	-1.2	0.0	-0.1	1.0	0.4	0.7	-1.4
Neck or shoulder pain in last month	1.8	2.5	5.7	-1.8	0.8	-2.4	-0.9	-1.9	-2.1	-0.7	-1.3	0.1	2.1
Medication: Blood pressure	8.9	15.6	30.3	-5.3	1.1	-5.5	-1.3	-4.5	-3.7	-5.3	-5.3	0.2	2.0
Angina (self-reported)	2.6	3.4	7.7	-2.3	0.9	-2.8	1.7	-1.8	-1.2	-2.2	-2.0	-0.6	1.9
Migraine (self-reported)	1.7	2.1	5.0	1.2	-2.2	1.9	0.3	1.7	0.8	1.7	1.4	0.0	-1.7
Medication: Ibuprofen	0.6	0.7	1.9	-0.2	0.6	-1.4	1.3	-0.5	-0.7	-0.8	0.1	-0.9	0.7
Medication: Allopurinol	0.9	1.2	3.8	-0.7	0.6	-1.2	0.6	-0.7	-0.7	-2.0	-1.7	0.9	0.3
Medication: Omeprazole	1.2	1.4	6.3	-0.5	-1.7	-1.0	2.5	-0.2	0.6	-0.3	-0.5	-1.1	1.2
Medication: Seretide 50 evohaler	0.2	0.3	0.9	0.7	-0.2	0.6	-0.2	-0.0	1.0	0.6	0.6	0.2	0.4
Mean time to correctly identify matches	2.5	4.7	9.0	3.0	-1.2	2.5	1.1	2.8	2.3	2.7	2.7	-0.1	-1.2
Heart disease (mother)	1.9	2.3	8.1	-1.9	-0.8	-1.1	-0.7	-1.9	-0.6	-1.3	-1.8	0.3	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.9	-0.1	1.0	0.0	0.1	0.5	0.1	-0.8	-0.7	-0.6	0.6
Whole body fat mass	0.7	3.0	5.6	1.4	-2.4	1.8	2.1	1.5	2.1	1.5	1.7	1.2	-0.8
Leg fat mass (right)	0.6	2.5	4.9	1.2	-2.0	1.6	2.2	1.4	2.0	1.5	1.5	1.1	-0.4
Arm predicted mass (right)	0.1	0.6	3.0	-0.2	-1.7	0.9	0.6	0.3	0.8	0.9	0.1	0.6	0.3
Pulse rate, automated reading	0.3	1.1	5.8	0.1	1.9	-0.7	0.6	0.2	-0.0	-0.5	-0.1	-2.4	0.3
Alcohol intake frequency.	0.1	0.2	0.9	-0.4	1.0	-0.9	-0.4	-0.4	-0.2	0.1	-0.0	0.4	0.2
Comparative height size at age 10	0.1	0.6	2.6	0.4	-0.3	0.7	-0.6	1.3	0.8	1.6	0.4	-0.3	-0.0
Number of full sisters	0.6	0.7	2.2	1.1	0.4	0.8	0.6	0.9	0.9	0.6	1.5	0.7	-0.5
Suffer from ‘nerves’	0.7	1.1	3.2	1.1	-0.6	1.5	-0.7	0.7	1.8	1.2	1.2	-0.5	0.6
Overall health rating	0.9	1.9	4.7	-2.0	-1.0	-2.2	-0.2	-1.8	-0.5	-1.6	-1.6	0.5	0.2
Chest pain or discomfort	0.3	0.4	1.6	0.6	1.3	-0.0	-0.6	0.3	0.2	0.4	1.0	0.7	0.1
Had major operations	5.6	6.6	13.4	-3.7	1.0	-2.2	-0.0	-3.6	-3.0	-2.9	-3.3	0.6	2.2
Age at last live birth	0.3	0.5	3.7	-0.6	0.1	-0.1	-1.9	-0.5	-0.3	-0.1	-0.6	0.2	0.0
Family relationship satisfaction	1.7	2.1	4.5	1.3	0.7	1.6	-1.2	1.5	1.0	1.7	1.6	2.1	-1.2
Leg pain on walking	0.4	0.5	2.7	0.2	0.7	0.0	1.6	0.2	0.4	0.6	0.5	-1.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.3	1.8	-1.6	2.1	1.2	1.6	1.1	1.2	1.5	0.8	-0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	4.9	-1.0	-0.6	-1.3	0.1	-0.6	0.0	-0.4	-0.8	-0.6	2.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.4	-0.2	0.3	-0.3	0.3	0.2	-0.5	-0.4	0.2	-1.2	-0.3
Medication: Aspirin	2.0	2.6	5.4	-1.9	1.6	-2.3	0.2	-1.1	-1.7	-2.1	-1.9	-0.6	1.3
Supplements: Vitamin C	0.9	1.1	3.9	0.7	-1.1	1.3	0.5	0.8	1.1	2.0	1.0	0.6	-0.1
Knee pain experienced in last month	0.4	0.7	3.7	-0.8	-0.7	-0.3	1.9	-0.9	0.3	-0.9	-0.4	-0.1	0.4
Hypertension (Self-reported)	4.4	12.3	26.8	-5.2	0.2	-4.8	-1.4	-3.7	-3.2	-4.2	-5.0	0.2	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.6	-1.1	0.5	-1.6	0.4	-0.7	-0.6	-1.2	-1.0	0.6	-0.4
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.8	-0.9	0.2	-0.1	-0.6	-0.8	0.1	-0.4	-0.2	0.6
Illnesses of siblings: Diabetes	0.5	0.6	1.4	-1.0	0.1	-0.5	-0.8	-1.1	0.2	-1.2	-1.1	0.7	0.2
Smoking status: Previous	3.2	4.8	9.4	-2.6	3.1	-2.1	0.6	-1.8	-2.9	-2.1	-2.9	1.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.0	0.2	0.3	0.7	-0.2	0.5	-0.4	0.3	-0.2	1.4	-1.0
Whole body fat-free mass	0.1	0.8	3.0	-0.2	-1.7	1.1	0.2	0.5	0.7	1.3	0.2	1.0	0.2
Leg fat-free mass (right)	0.3	1.5	4.4	0.5	-2.1	1.5	0.3	0.9	1.1	1.7	0.9	1.5	-0.2
Arm fat percentage (left)	0.7	2.9	4.8	1.5	-1.9	1.9	2.2	1.5	2.2	1.3	1.7	1.7	-1.0
Average weekly red wine intake	0.9	1.3	2.3	1.3	-0.8	1.2	1.0	1.3	0.6	1.5	1.0	-1.4	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.0	0.2	1.4	-0.7	-1.1	0.5	-0.3	-0.7	0.0	-0.8	0.2
Mood swings	0.2	0.4	1.2	-0.7	-0.7	-0.3	0.9	-0.9	-0.1	-0.3	-0.5	0.1	1.1
Loneliness, isolation	1.0	1.4	2.6	-1.6	0.4	-1.4	0.4	-1.4	-1.5	-0.9	-1.5	-0.6	1.3
Long-standing illness, disability or infirmity	0.4	0.7	3.4	-0.7	-0.4	-1.1	1.8	-0.7	-0.5	-0.9	0.1	-0.2	-0.2
Ever had bowel cancer screening	1.0	1.1	2.9	0.6	-0.9	1.0	1.5	0.7	0.9	1.7	0.7	-0.7	-1.3
Diabetes diagnosed by doctor	1.0	1.7	3.5	-1.7	0.5	-1.6	1.0	-1.1	-1.7	-1.6	-1.9	0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.9	-1.2	-0.9	-0.2	1.0	-0.0	-0.8	-0.3	-1.7	-0.4	-0.4
Friendships satisfaction	3.7	4.6	10.2	2.4	-1.2	2.7	0.6	2.3	1.5	3.2	2.9	0.8	-2.2
Qualifications: nursing, teaching	0.1	0.1	0.5	0.0	0.5	-0.4	-0.1	0.7	-0.3	-0.4	0.2	-0.2	0.5
Commuting to job workplace: Walk	2.0	2.1	3.4	1.6	-1.3	1.8	1.2	1.5	1.0	1.3	1.3	-1.6	-1.7
Eye problems/disorders: Cataract	0.3	0.3	1.3	0.2	0.8	-0.9	-1.2	0.2	0.2	-0.3	0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.8	-0.7	-0.7	-0.4	0.4	-0.2	-1.0	-0.6	-0.7	-1.7	-0.8
Medication for cholesterol	3.5	5.3	11.6	3.0	-0.7	3.4	0.3	2.6	2.6	2.2	2.5	1.5	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	-1.4	0.6	-0.6	-0.5	-0.5	-1.0	-0.5	-1.4	0.8	0.7
Back pain experienced in last month	0.4	0.6	1.5	0.8	0.6	0.4	0.1	1.2	0.6	1.1	0.6	0.8	-1.0
Mineral and other dietary supplements	0.2	0.3	1.2	0.4	-0.6	0.1	0.7	0.4	-0.5	-0.4	0.4	-1.1	0.1
Breast cancer (self-reported)	5.3	6.3	9.7	2.9	-1.6	2.8	2.7	2.8	2.5	2.7	3.1	-0.5	-2.4
Asthma (self-reported)	1.2	2.3	5.1	1.8	0.8	1.8	-0.5	2.2	2.1	1.8	1.8	0.0	0.5
Osteoporosis (self-reported)	1.4	1.7	4.6	-1.3	0.5	-1.4	1.1	-1.3	-2.1	-0.9	-1.2	-1.1	1.4
Osteoarthritis (self-reported)	1.1	1.4	3.7	-1.3	1.0	-1.5	0.8	-1.4	-0.4	-1.0	-0.9	-1.9	1.1
Medication: Aspirin	2.4	3.1	6.2	-2.2	1.4	-2.5	-0.0	-1.4	-1.8	-2.5	-2.2	-0.1	1.5
Medication: Gliclazide	1.5	1.7	4.1	-1.9	-1.0	-1.5	0.4	-1.7	-0.8	-1.5	-2.0	0.2	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	1.1	-0.8	0.3	0.6	0.5	1.0	0.5	0.9	0.3	1.0
Smoking status: Current	1.3	2.0	5.5	-1.3	-0.9	-1.2	0.8	-1.2	-0.9	-1.7	-1.4	-2.3	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.3	1.8	-0.2	2.3	-0.0	1.7	0.9	2.2	1.8	-0.8	-1.3
Whole body water mass	0.1	0.7	3.3	-0.2	-1.8	1.0	0.2	0.5	0.6	1.3	0.2	0.9	0.1
Leg predicted mass (right)	0.3	1.4	4.4	0.4	-2.1	1.5	0.4	0.8	1.1	1.6	0.9	1.5	-0.2
Arm fat mass (left)	0.6	2.6	4.8	1.2	-2.2	1.8	2.0	1.4	1.9	1.4	1.4	1.5	-0.7
Number of self-reported non-cancer illnesses	1.7	3.0	8.3	-1.7	-1.0	-2.9	1.4	-1.5	-1.8	-1.4	-1.3	-2.4	1.1
Average weekly champagne plus white wine intake	0.5	0.8	3.0	-0.7	-0.9	-0.7	0.1	-0.8	-1.7	-0.1	-0.4	-1.1	0.7
Miserableness	0.6	1.1	2.5	1.3	-0.6	1.3	0.3	1.6	0.8	1.3	1.2	0.2	-1.0
Guilty feelings	0.9	1.4	4.7	-1.1	-0.9	-0.8	1.8	-1.0	-1.1	-0.3	-0.9	-2.2	0.4
Wears glasses or contact lenses	1.2	1.4	4.8	-1.0	0.6	-1.2	0.6	-1.6	-0.5	-0.7	-0.6	-1.6	2.2
Ever taken oral contraceptive pill	0.6	0.7	2.5	0.2	-1.2	0.5	-0.0	0.4	0.6	0.8	-0.1	-1.3	-1.6
Hearing aid user	0.8	0.9	5.2	0.9	-0.4	1.0	-0.7	0.9	0.7	0.2	0.5	0.1	-2.3
Mother’s age at death	1.4	1.7	3.7	1.6	-1.0	1.3	0.4	1.6	1.6	1.9	1.7	0.1	0.1
Financial situation satisfaction	1.7	2.1	6.7	1.7	-1.3	0.9	2.6	1.3	1.0	0.1	1.3	-0.9	-1.9
Tinnitus: Yes, now most or all of the time	1.2	1.3	3.7	-1.2	1.1	-1.1	-1.1	-0.5	-0.8	-0.8	-1.8	1.9	0.1
Commuting to job workplace: Public transport	1.2	1.4	3.6	1.3	-0.6	1.1	1.8	1.0	-0.7	0.4	1.3	0.8	-1.9
Eye problems/disorders: Glaucoma	0.9	1.1	3.1	-1.1	0.4	-1.8	-0.4	-1.2	-0.9	-1.1	-0.9	-0.3	1.2
Medication: Blood pressure	5.4	10.2	22.6	-4.4	0.8	-4.8	-1.0	-3.2	-3.1	-3.5	-4.1	-1.0	2.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	11.4	0.6	-3.4	-0.8	0.8	0.9	1.9	0.6	0.4	-0.7	-1.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.4	0.8	-0.1	-0.6	0.5	1.0	0.6	0.5	1.3	0.2
High cholesterol (Self-reported)	0.4	0.7	2.4	-0.4	-1.0	-0.6	1.4	-0.3	-0.8	-0.1	-0.4	-0.5	-1.6
Medication: Bendroflumethiazide	2.9	4.4	8.5	-2.6	1.2	-2.9	-2.3	-2.4	-1.8	-1.6	-2.2	-0.3	2.4
Medication: Paracetamol	0.4	0.5	1.7	0.2	1.3	0.3	0.4	0.2	0.6	0.6	0.6	-0.7	1.3
Medication: Lisinopril	5.0	6.5	12.6	-3.2	1.1	-3.5	-1.0	-2.6	-2.9	-3.0	-2.8	-1.5	2.4
Medication: Atorvastatin	0.4	0.5	1.5	0.3	-1.2	0.2	1.0	0.4	1.2	0.8	0.2	0.4	-0.1
Illnesses of father: High blood pressure	1.5	1.9	5.3	-1.7	-1.2	-1.0	-0.7	-1.2	-0.8	-1.7	-2.3	0.6	-1.5
Alcohol drinker status: Never	0.9	1.1	3.9	-0.6	1.2	-1.1	0.9	-1.0	-1.2	0.0	0.6	-0.8	2.0
Ever smoked	1.8	3.1	5.3	-2.2	1.5	-1.9	0.1	-1.7	-2.3	-2.2	-2.3	0.1	1.6
Basal metabolic rate	0.2	1.1	4.2	0.1	-2.1	1.2	0.7	0.7	1.0	1.4	0.5	1.1	-0.0
Leg fat percentage (left)	0.8	2.8	6.3	1.4	-2.1	1.7	2.5	1.5	2.3	1.3	1.5	0.7	-0.4
Arm fat-free mass (left)	0.2	0.9	5.1	-0.0	-2.3	0.7	0.5	0.6	0.8	1.3	0.3	0.3	0.3
Number of operations (self-reported)	1.4	2.0	5.0	-2.2	0.7	-2.0	-0.3	-1.7	-1.7	-1.1	-1.7	-0.1	0.9
Average weekly beer plus cider intake	0.6	0.9	2.2	-1.5	0.6	-1.2	0.2	-0.6	-0.4	-1.0	-1.1	0.3	1.3
Irritability	0.1	0.1	0.4	-0.1	-0.5	0.3	0.6	-0.2	-0.3	-0.0	0.6	0.4	-0.1
Risk taking	0.1	0.2	0.6	-0.4	0.8	0.2	0.6	-0.4	-0.2	-0.4	-0.5	-0.4	0.5
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.7	-2.2	0.1	-1.9	1.0	-1.8	-1.2	-1.5	-1.8	-0.4	1.7
Fractured/broken bones in last 5 years	0.2	0.2	1.0	-0.2	0.1	-0.3	-1.0	-0.1	-0.2	-0.2	-0.7	0.4	-0.2
Age started oral contraceptive pill	0.2	0.3	0.9	-0.2	-0.5	-0.2	-0.6	-0.7	0.7	0.2	-0.1	-0.2	0.9
Diastolic blood pressure, automated reading	1.0	3.1	5.4	-2.3	-0.9	-2.3	-1.1	-1.6	-1.2	-2.2	-2.2	-1.5	1.7
Ever depressed for a whole week	1.2	1.5	3.8	1.0	-1.4	1.8	1.9	0.7	0.5	1.5	1.0	-0.6	-1.2
Unable to work because of sickness or disability	0.2	0.3	1.8	-0.3	-0.5	0.0	1.3	-0.7	0.2	-0.4	-0.1	0.2	0.0
Commuting to job workplace: Cycle	0.6	0.7	2.8	-0.5	-0.4	0.6	-1.7	-0.7	-0.1	-0.3	-0.4	1.1	-1.2
Myopia	2.4	3.5	11.5	2.3	-3.4	1.3	1.6	1.9	1.8	1.3	2.4	-0.5	-0.6
Vascular/heart problems diagnosed by doctor	6.4	17.4	36.5	6.0	-1.1	6.0	1.0	4.4	4.2	4.7	5.5	0.4	-3.2
Cholesterol lowering medication	0.4	0.5	4.5	0.2	-0.2	-0.0	0.6	0.5	0.2	0.1	0.4	-0.2	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	4.3	-0.6	-0.6	-1.0	2.1	-0.3	0.3	-0.2	-0.6	-1.0	1.1
Pain experienced in last month	0.1	0.2	0.9	0.2	-0.4	0.7	-0.9	0.1	0.2	0.0	-0.3	0.0	-0.1
Supplements: Calcium	3.0	3.3	4.8	1.9	-0.7	2.2	2.1	1.7	2.1	2.1	2.1	1.3	-1.5
Basal cell carcinoma (self-reported)	1.9	2.3	7.0	1.4	-1.0	1.5	-1.6	1.3	2.7	1.6	1.7	-0.9	-0.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.4	-1.5	0.5	-1.8	-0.3	-1.3	-0.4	-1.8	-1.2	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	5.9	-1.8	0.7	-1.8	-1.4	-1.6	-2.4	-2.3	-1.9	1.0	1.1
Heart disease (siblings)	0.5	0.6	1.5	-0.8	0.4	-1.2	-0.3	-0.7	-0.3	-0.3	-0.6	-1.1	1.1
Alcohol drinker status: Previous	0.4	0.5	2.1	0.2	0.3	0.6	-1.0	0.4	0.3	1.1	0.3	1.4	-0.3
Pack years of smoking	0.4	0.5	2.4	0.7	0.3	0.1	0.5	0.6	1.6	0.3	0.3	-0.1	1.3
Impedance of whole body	0.5	2.3	6.5	2.6	-0.3	1.5	-0.1	1.6	2.0	1.1	2.0	0.3	-1.6
Leg fat mass (left)	0.6	2.3	4.8	1.0	-2.1	1.5	2.2	1.2	2.0	1.4	1.2	1.2	-0.2
Arm predicted mass (left)	0.1	0.6	3.3	-0.2	-1.8	0.7	0.3	0.4	0.7	1.2	0.2	0.4	0.2