TWAS hub - EPHX4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.045	0.020	3.2e-03	0.036	0.028	0.044	0.040	0.044	3.1e-05	0.00022	3.8e-06	1.0e-05	4.3e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.106	0.034	6.3e-05	0.098	0.019	0.097	0.091	0.101	1.4e-12	0.00130	1.7e-12	8.3e-12	7.1e-13
3	TCGA	Pheochromocytoma and Paraganglioma	0.082	0.049	9.2e-03	0.027	0.017	-0.006	NA	0.006	3.0e-02	0.06600	6.4e-01	NA	1.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Qualifications: CSEs or equivalent	5.4	7.1	8.6	2.8	2.9	2.2
Number of live births	4.8	6.8	9.3	-3.0	-2.2	-2.5
Guilty feelings	4.5	6.8	11.6	2.7	-1.3	-3.4
Average weekly spirits intake	4.2	5.2	7.6	-0.9	-2.7	-2.8
Chronic bronchitis/emphysema (father)	3.9	4.5	7.6	-0.6	-2.4	-2.8
Medication: Blood pressure	3.8	7.3	14.8	-1.2	-3.8	-2.4
Eye problems/disorders: Cataract	3.5	4.1	5.1	-1.6	-2.3	-2.1
Vascular/heart problems diagnosed by doctor	3.2	8.7	17.4	0.4	4.2	2.9
Bipolar Disorder (2018)	2.8	4.4	8.0	2.8	1.6	1.6
Lung FEV1/FVC ratio	2.8	14.4	43.2	6.6	-0.2	0.1
Wears glasses or contact lenses	2.8	3.3	5.5	-1.3	-1.6	-2.3
Basal cell carcinoma (self-reported)	2.8	3.3	6.5	-2.5	-1.9	-0.1
Past tobacco smoking	2.7	5.0	6.3	2.5	2.4	1.7
Knee pain experienced in last month	2.7	4.3	7.2	-1.0	2.1	2.7
Smoking status: Previous	2.7	4.1	5.0	-2.2	-2.2	-1.6
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	4.2	1.5	1.7	2.0
Hypertension (Self-reported)	2.6	7.1	13.3	-0.5	-3.6	-2.8
High blood pressure	2.5	6.9	13.2	-0.4	-3.6	-2.7
Number of operations (self-reported)	2.5	3.7	6.1	-0.3	-2.5	-2.2
Reaction Time	2.4	4.5	11.5	3.4	-0.1	-1.4
Schizophrenia vs Biploar Disorder	2.3	3.0	4.2	-1.9	-2.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	4.1	0.3	-2.0	-1.9
Supplements: Calcium	2.2	2.4	3.6	-0.9	1.9	1.6
Worrier / anxious feelings	2.1	4.0	7.2	0.8	-2.1	-2.7
Number of full brothers	2.0	2.6	5.3	0.2	-2.3	-1.5
Loneliness, isolation	2.0	2.7	7.1	2.7	-0.0	-1.0
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.0	1.9	-0.7	-2.0
Taking other prescription medications	1.9	2.9	4.8	0.0	2.0	2.2
Medication: Bendroflumethiazide	1.9	2.9	4.6	0.9	-2.2	-1.8
Worry (Nagel 2018)	1.8	3.8	8.0	1.6	-0.9	-2.8
Ever had hysterectomy (womb removed)	1.8	2.1	2.7	-1.2	1.4	1.6
Had menopause	1.8	2.3	6.6	-2.6	0.0	-0.5
Heart attack	1.8	2.3	4.7	-0.7	-2.2	-1.3
Family relationship satisfaction	1.8	2.2	5.0	2.2	1.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.7	-1.0	-1.9	-1.2
Depression (Nagel 2018)	1.7	2.5	4.5	2.1	-0.0	-1.7
Neuroticism (Nagel 2018)	1.7	3.9	7.9	2.8	-0.1	-1.9
Lung FVC	1.7	8.7	25.0	-5.0	-0.7	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.7	2.4	0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.8	-0.1	1.9	1.7
Asthma	1.7	3.3	4.0	2.0	1.4	2.0
Depression (self-reported)	1.7	2.0	4.9	-0.0	-1.1	-2.2
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.7	0.8	1.6	1.6
Chronic bronchitis/emphysema (mother)	1.7	2.0	5.1	2.3	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.0	-0.1	1.7	1.7
Medication: Blood pressure	1.7	2.9	6.6	0.6	-2.6	-1.4
Suffer from ‘nerves’	1.7	2.7	5.6	1.5	-0.5	-2.4
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.2	1.2	2.0	0.4
Neck or shoulder pain in last month	1.6	2.3	5.1	0.7	1.2	2.2
Asthma (self-reported)	1.6	3.1	4.4	2.1	1.2	1.9
Ever depressed for a whole week	1.6	2.0	2.9	0.9	1.5	1.7
Rheumatoid Arthritis	1.5	2.0	4.8	-2.2	-1.1	-0.1
Severe depression (siblings)	1.5	1.6	3.0	-0.5	-1.7	-1.3
Multivitamins +/- minerals	1.5	1.9	2.9	-1.4	-0.9	-1.7
Noisy workplace	1.5	1.9	2.7	1.6	1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	5.3	2.3	1.4	1.4
Average weekly red wine intake	1.5	2.2	5.3	-2.3	-0.9	-0.8
Ever taken oral contraceptive pill	1.5	1.7	4.8	2.2	0.4	0.2
Illnesses of father: High blood pressure	1.5	1.9	4.8	-0.1	0.9	2.2
Age started oral contraceptive pill	1.5	1.8	4.5	-2.1	0.1	-1.0
Alzheimer’s Disease (in mother)	1.4	1.7	2.8	1.7	-0.2	-1.4
Medication: Co-codamol	1.4	1.6	4.8	2.2	0.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.0	-1.7	1.0	0.8
Illnesses of mother	1.4	1.7	3.2	-1.8	1.1	0.9
Birth weight	1.4	3.0	4.4	2.1	0.8	2.0
Number of full sisters	1.4	1.7	2.6	0.2	1.6	1.5
Illnesses of siblings: Diabetes	1.4	1.8	2.4	1.0	1.4	1.6
Miserableness	1.4	2.5	7.3	2.7	0.3	-0.3
Ever smoked	1.4	2.5	4.5	-2.1	-1.5	-0.9
Irritability	1.4	2.3	3.1	1.1	1.6	1.8
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.5	-0.8	-1.9	-1.1
Heart disease (siblings)	1.4	1.7	2.6	1.6	0.8	1.4
Bipolar Disorder (2011)	1.3	1.2	2.9	1.7	0.9	0.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.4	-1.0	1.0	1.6
Length of working week for main job	1.3	1.4	3.6	0.5	0.6	1.9
Hair/balding pattern: Pattern 4	1.3	3.0	9.1	3.0	0.3	-0.0
Medication: Amlodipine	1.3	1.8	2.8	0.2	-1.6	-1.7
Depressed Affect (Nagel 2018)	1.2	2.5	7.0	2.6	0.7	0.0
Ulcerative Colitis (UC)	1.2	2.3	5.2	2.3	-0.5	-1.2
Prostate Cancer	1.2	1.6	1.9	1.2	1.4	1.3
Lupus	1.2	1.7	3.6	-1.9	0.2	1.3
Neuroticism score	1.2	2.6	5.2	2.3	0.1	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.3	2.1	1.2	-0.0
Mean time to correctly identify matches	1.2	2.3	4.8	2.2	-0.2	-1.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.2	0.0	1.5	1.4
Medication: Lisinopril	1.2	1.6	2.6	-1.5	-1.6	-0.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.3	1.8	-0.6	-0.8
Cardiovascular Disease	1.1	3.6	7.8	0.2	-2.8	-1.7
Fed-up feelings	1.1	2.1	5.6	2.4	0.2	-0.8
Medication: Atenolol	1.1	1.4	1.8	-0.9	-1.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.4	2.1	0.1	-0.9
Health satisfaction	1.1	1.5	2.7	1.6	1.2	0.4
Eye problems/disorders: None of the above	1.1	1.3	1.8	0.8	1.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.9	1.1	-0.9	-1.4
Had major operations	1.1	1.3	1.9	-0.5	-1.4	-1.3
Irritable Bowel Disease (IBD)	1.0	2.4	4.6	2.1	-0.2	-1.6
LDL Cholesterol	1.0	1.6	3.8	0.9	1.9	0.5
Respiratory disease	1.0	2.3	3.8	0.6	1.7	2.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.0	-1.3	-1.4	-0.6
Stomach or abdominal pain in last month	1.0	1.3	3.8	-1.9	0.1	0.1
Time employed in main current job	1.0	1.1	1.6	-0.5	1.2	1.3
Headache pain in last month	1.0	1.7	4.1	0.3	2.0	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.6	0.8	1.2	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.2	1.8	0.2	0.6
Illnesses of father: Heart disease	1.0	1.3	3.7	1.9	0.3	0.3
Medication for cholesterol	1.0	1.4	3.0	-0.5	1.7	1.1
Eye problems/disorders: Glaucoma	1.0	1.1	2.1	0.5	1.4	1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.6	1.9	0.4	0.1
Risk taking	1.0	1.5	4.2	0.4	-0.4	-2.1
Age at First Birth	0.9	1.3	3.3	0.5	-0.6	-1.8
Vitamin and mineral supplements	0.9	1.3	1.9	1.2	0.7	1.4
Forced vital capacity (FVC)	0.9	3.5	8.6	-2.9	0.7	1.2
Mouth/teeth dental problems: Dentures	0.9	1.6	3.0	-1.7	-1.3	-0.4
Loud music exposure frequency	0.9	0.9	1.1	-1.0	0.9	0.9
Hearing aid user	0.9	1.1	2.8	1.7	0.5	-0.3
Smoking Status	0.8	1.8	2.6	-1.3	-1.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-0.4	1.4	0.9
Hearing difficulty/problems with background noise	0.8	1.3	2.3	0.9	-0.9	-1.5
Alcohol intake versus 10 years previously	0.8	1.2	3.0	1.7	0.7	-0.3
Medication: Lansoprazole	0.8	1.0	1.4	-1.2	-0.7	1.0
Breastfed as a baby	0.8	1.0	2.0	-0.3	-1.4	-0.8
Medication: Omeprazole	0.8	1.0	1.2	-0.9	-1.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.2	-0.7	1.1	0.9
Qualifications: nursing, teaching	0.8	1.3	2.0	0.1	1.4	1.4
Osteoporosis (self-reported)	0.8	1.0	2.9	-1.7	-0.4	0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.9	-1.4	-0.5	-1.0
Average weekly beer plus cider intake	0.8	1.1	2.6	1.6	-0.6	-0.7
Pain experienced in last month	0.8	1.4	2.2	-0.6	-1.5	-1.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.6	0.7	1.1	2.1
Allergy or Eczema	0.7	1.9	5.1	2.2	0.2	0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.6	-0.4	-0.8	-1.6
Sitting height	0.7	4.7	6.6	-1.3	2.4	2.6
High blood pressure (mother)	0.7	1.0	1.8	1.3	0.6	0.9
Waist circumference	0.7	2.5	6.1	-0.6	-2.5	-1.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.2	-0.8	-1.0	-1.1
Exposure to tobacco smoke at home	0.7	0.8	1.3	0.1	1.2	1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.8	-0.7	1.3	1.1
Number of children fathered	0.7	0.8	2.1	-1.4	0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.7	-0.7	0.3	1.3
Average weekly champagne plus white wine intake	0.7	1.0	2.8	-1.7	0.1	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-0.1	-0.5	1.5
Crohns Disease (2017)	0.6	1.3	2.0	1.3	0.3	-1.4
Fasting Glucose	0.6	0.7	0.9	-0.9	-0.6	-1.0
HbA1C	0.6	0.7	1.4	1.2	0.8	-0.0
Neuroticism	0.6	1.5	2.8	1.7	0.3	-1.2
Medication for hormone replacement therapy	0.6	0.6	1.1	0.9	1.1	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.2	1.5	0.5	1.2
Impedance of leg (left)	0.6	3.0	6.7	2.6	1.4	0.5
Alcohol usually taken with meals	0.6	1.0	2.8	-1.7	-0.1	-0.4
Nervous feelings	0.6	1.2	3.0	0.8	-0.2	-1.7
Allergy	0.6	1.3	2.2	-1.5	-0.8	-1.0
Illnesses of siblings	0.6	0.8	2.2	-1.5	0.4	0.3
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	-0.0	1.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.9	-0.2	1.4	0.9
Comparative body size at age 10	0.6	1.7	3.4	-1.3	-1.8	0.1
Worry too long after embarrassment	0.6	1.0	1.9	1.1	0.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	1.0	1.2	-0.1
Medication: Allopurinol	0.6	0.8	2.1	-1.5	-0.4	0.2
Medication: Seretide 50 evohaler	0.6	0.6	1.4	-0.7	-0.1	1.2
Heart disease (mother)	0.6	0.7	1.8	1.3	-0.3	-0.6
Friendships satisfaction	0.6	0.7	2.0	1.4	0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	-0.7	1.3	0.9
Breast cancer (self-reported)	0.6	0.7	1.6	0.1	1.3	0.7
Mother’s age at death	0.6	0.7	1.7	-1.3	-0.5	-0.5
Medication: Paracetamol	0.6	0.9	1.8	1.3	0.8	0.4
Alcohol drinker status: Never	0.6	0.8	1.4	1.2	0.8	0.6
Myopia	0.6	0.8	1.7	-0.6	-0.6	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.2	2.6	1.6	0.6	0.7
Major Depression (MDD)	0.5	0.6	1.3	1.1	-0.7	-0.2
Breast Cancer	0.5	1.2	2.3	-0.5	1.5	1.1
Mean Putamen Volume	0.5	0.6	1.1	0.3	-1.1	-0.8
Blood Red Count	0.5	4.8	9.5	-3.1	-2.2	-0.3
Heel T-Score	0.5	4.4	11.5	3.4	0.4	-1.2
Sensitivity / hurt feelings	0.5	0.8	1.7	1.3	0.7	-0.3
Impedance of leg (right)	0.5	2.4	5.2	2.3	1.4	0.0
Average weekly fortified wine intake	0.5	0.6	1.2	-1.1	-0.3	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.9	-0.9	-0.4
Diabetes (self-reported)	0.5	0.8	1.6	-0.5	-1.3	-0.6
Medication: Ramipril	0.5	0.6	0.8	0.9	-0.9	-0.6
Arm fat percentage (right)	0.5	2.0	4.5	-0.1	-2.1	-1.2
Father’s age at death	0.5	0.7	1.1	-0.9	0.3	1.0
Happiness	0.5	0.5	0.9	0.6	0.6	-0.9
Peak expiratory flow (PEF)	0.5	1.1	2.3	-0.7	-1.5	0.8
Pulse wave reflection index	0.5	0.6	1.3	1.1	0.6	-0.5
Medication: Paracetamol	0.5	0.8	1.5	0.9	1.2	0.3
Gout (self-reported)	0.5	0.7	1.7	-1.3	-0.6	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.9	3.6	-1.9	1.1	1.0
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.9	-1.1	-0.2
Shortness of breath walking on level ground	0.5	0.6	1.8	0.2	1.3	0.1
Medication: Gliclazide	0.5	0.6	1.0	-1.0	-0.6	-0.6
Financial situation satisfaction	0.5	0.6	0.8	0.8	0.9	-0.6
Alcohol drinker status: Previous	0.5	0.6	1.0	1.0	-0.4	-0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	1.2	-0.0	-0.6
Ovarian Cancer	0.4	0.6	1.6	-1.3	-0.1	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.1	0.1	-1.0	-0.6
Blood Platelet Count	0.4	4.8	8.4	-2.9	-1.3	-2.0
Height	0.4	6.9	11.8	-1.0	3.4	2.8
Hand grip strength (left)	0.4	0.9	1.4	-1.2	0.8	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.2	0.9	0.6
Body mass index (BMI)	0.4	1.6	4.1	-0.4	-2.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.4	-0.6	-1.1
Fluid intelligence score	0.4	0.9	1.5	-1.1	-0.0	1.2
Falls in the last year	0.4	0.6	1.5	-1.2	-0.5	0.3
Pulse rate	0.4	0.6	0.7	0.8	0.6	0.9
Lung cancer (father)	0.4	0.4	0.7	-0.8	0.8	0.2
Standing height	0.4	3.9	7.3	-0.6	2.7	2.0
Comparative height size at age 10	0.4	2.1	4.4	0.8	2.1	1.1
Overall health rating	0.4	0.9	1.8	1.3	-0.6	-0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.1	-0.4	-0.4
Back pain experienced in last month	0.4	0.6	0.9	0.6	0.7	0.9
Mineral and other dietary supplements	0.4	0.6	1.1	0.5	0.5	1.1
Medication: Atorvastatin	0.4	0.5	0.7	0.4	-0.8	-0.7
Chronotype (morning person)	0.3	0.8	2.2	1.5	0.1	0.1
Systolic blood pressure, automated reading	0.3	0.9	2.2	-1.5	0.6	0.5
Medication: Metformin	0.3	0.5	1.2	1.1	0.2	0.5
Diabetes (mother)	0.3	0.4	1.0	1.0	0.1	0.3
Hand grip strength (right)	0.3	0.7	1.1	-0.7	0.6	1.1
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.4	0.5	0.9
Supplements: Glucosamine	0.3	0.4	1.2	0.4	-0.1	-1.1
Number of incorrect matches in round	0.3	0.5	0.6	0.8	-0.7	-0.5
Had other major operations	0.3	0.3	0.6	-0.3	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	0.3	-0.7	-1.3
Pain all over the body in last month	0.3	0.3	0.7	0.4	0.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-1.3	0.1	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.5	-0.7	-1.1
Tense / ‘highly strung’	0.3	0.5	1.4	0.2	-0.5	-1.2
Glaucoma (self-reported)	0.3	0.3	0.5	-0.4	0.7	0.6
High blood pressure (siblings)	0.3	0.4	1.0	1.0	-0.0	-0.2
Arm fat-free mass (right)	0.3	1.4	3.1	-0.8	0.8	1.8
Emphysema/chronic bronchitis	0.3	0.3	0.4	-0.5	0.7	-0.5
Arm predicted mass (right)	0.3	1.7	3.4	-0.6	1.1	1.8
Pulse rate, automated reading	0.3	0.9	1.9	0.2	-1.4	-0.9
Supplements: Vitamin C	0.3	0.4	1.0	-1.0	-0.0	0.5
Arm fat percentage (left)	0.3	1.4	3.6	-0.1	-1.9	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	1.3	0.3	0.2	1.1
Osteoarthritis (self-reported)	0.3	0.3	0.5	0.4	0.7	0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	0.5	-0.7	-0.4	-0.5
Commuting to job workplace: Public transport	0.3	0.3	0.5	0.7	0.1	0.6
Diastolic blood pressure, automated reading	0.3	0.9	2.7	1.6	0.3	-0.1
Unable to work because of sickness or disability	0.3	0.3	0.8	0.3	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.2	-0.8	-0.6
Impedance of whole body	0.3	1.5	4.0	2.0	0.7	0.2
Arm predicted mass (left)	0.3	1.3	2.2	-0.9	0.9	1.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.1	0.4	-0.8
Crohns Disease (2012)	0.2	0.4	1.0	0.3	-0.1	-1.0
HDL Cholesterol	0.2	0.4	0.7	-0.7	-0.8	-0.1
Neuroticism (2016)	0.2	0.3	0.7	0.8	0.4	-0.4
Schizophrenia (2014)	0.2	0.3	0.5	0.2	-0.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.1	0.7	0.1
BMI	0.2	0.9	2.2	-0.6	-1.5	-0.5
Tanning	0.2	3.0	6.4	-2.5	0.5	1.6
Pack years adult smoking proportion	0.2	0.3	0.8	0.9	0.1	0.5
Trunk fat percentage	0.2	0.8	2.3	0.1	-1.5	-0.3
Relative age voice broke	0.2	0.3	0.4	0.7	0.2	-0.6
Age when periods started (menarche)	0.2	0.4	0.8	0.7	0.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.7	-0.2	-0.2
Qualifications: None of the above	0.2	0.5	1.0	-0.2	-1.0	-0.5
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	-0.2	-0.5
Medication: Simvastatin	0.2	0.2	0.4	-0.6	-0.2	0.6
Trunk fat-free mass	0.2	1.2	1.5	-0.8	1.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	-0.7	0.5	1.0
Arm fat mass (right)	0.2	0.7	2.0	-0.3	-1.4	-0.4
Trunk predicted mass	0.2	1.2	1.4	-0.8	1.2	1.2
Birth weight of first child	0.2	0.4	1.1	0.1	1.1	0.3
Body fat percentage	0.2	1.0	2.5	0.2	-1.6	-0.5
Leg fat percentage (right)	0.2	0.8	1.5	0.4	-1.2	-0.8
Qualifications: College or University degree	0.2	0.6	1.1	1.1	0.5	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.1	0.4	0.8
Migraine (self-reported)	0.2	0.2	0.4	0.3	-0.3	-0.7
Alcohol intake frequency.	0.2	0.6	1.7	1.3	0.1	-0.2
Leg pain on walking	0.2	0.2	0.5	-0.1	0.7	0.3
Whole body fat-free mass	0.2	1.1	1.8	-0.9	0.9	1.3
Mood swings	0.2	0.4	1.0	1.0	0.2	-0.1
Ever had bowel cancer screening	0.2	0.2	0.6	0.8	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.1	0.9	0.5
Whole body water mass	0.2	1.2	1.9	-0.9	0.9	1.4
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.5	-0.8	0.1
Leg fat percentage (left)	0.2	0.7	1.7	0.5	-1.3	-0.5
Arm fat-free mass (left)	0.2	1.2	1.8	-0.9	1.0	1.4
Cholesterol lowering medication	0.2	0.2	0.7	0.1	-0.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.3	-0.2	-0.7
Pack years of smoking	0.2	0.3	0.8	0.9	0.1	0.3
Schizophrenia (2018)	0.1	0.2	0.3	-0.2	-0.6	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.1	0.3	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.2	0.2	-0.6
Triglycerides	0.1	0.2	0.4	0.1	0.6	-0.5
Ulcerative Colitis	0.1	0.1	0.3	0.6	-0.2	0.1
Waist Hip Ratio (WHR)	0.1	0.4	0.9	0.5	-0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.1	0.3	0.7
Relative age of first facial hair	0.1	0.2	0.5	0.7	0.3	0.3
Angina	0.1	0.1	0.3	-0.2	-0.6	0.3
Supplements: Zinc	0.1	0.1	0.2	-0.2	0.5	0.3
Leg fat-free mass (left)	0.1	0.6	1.3	-0.7	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.0	0.0	-0.7
Leg predicted mass (left)	0.1	0.6	1.2	-0.7	0.3	1.1
Trunk fat mass	0.1	0.3	0.8	-0.2	-0.9	0.2
Weight	0.1	0.3	0.5	-0.5	-0.7	0.2
Impedance of arm (right)	0.1	0.7	1.6	1.3	0.1	-0.6
Hip circumference	0.1	0.2	0.6	0.2	-0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.3	0.4	-0.4
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.3	-0.7	-0.2
Prospective memory result	0.1	0.1	0.2	0.4	0.0	0.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.3	0.2	0.6
Impedance of arm (left)	0.1	0.5	1.2	1.1	0.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.2	-0.1	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.3	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	-0.6	-0.7	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.2	0.5	0.4
Age at first live birth	0.1	0.2	0.4	0.7	0.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.2	-0.4
Angina (self-reported)	0.1	0.1	0.2	0.0	-0.4	0.3
Medication: Ibuprofen	0.1	0.1	0.2	0.5	0.1	-0.3
Whole body fat mass	0.1	0.4	1.1	-0.1	-1.1	-0.1
Leg fat mass (right)	0.1	0.3	0.8	0.1	-0.9	-0.3
Chest pain or discomfort	0.1	0.2	0.4	0.0	0.6	0.5
Medication: Aspirin	0.1	0.2	0.3	-0.5	0.1	0.4
Leg fat-free mass (right)	0.1	0.7	1.6	-0.6	0.3	1.3
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.3	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	-0.3	0.5
Leg predicted mass (right)	0.1	0.7	1.6	-0.6	0.3	1.3
Arm fat mass (left)	0.1	0.4	1.3	-0.2	-1.1	0.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.1	0.3	-0.4	-0.2
Basal metabolic rate	0.1	0.7	1.4	-0.6	0.6	1.2
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.3	0.6	-0.3
Leg fat mass (left)	0.1	0.3	0.7	0.3	-0.8	-0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.1	0.1	0.4
Blood Eosinophil Count	0.0	0.1	0.2	0.4	0.1	0.4
Blood White Count	0.0	0.3	0.6	-0.4	-0.3	0.8
Systolic Blood Pressure	0.0	0.1	0.3	0.6	-0.1	0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	0.1	-0.2	0.5
Hair Pigment	0.0	1.2	2.6	-1.6	-0.9	-0.5
Number of treatments/medications taken	0.0	0.0	0.1	0.0	-0.2	-0.3
Diabetes (father)	0.0	0.0	0.0	0.0	-0.1	0.1
Current tobacco smoking	0.0	0.1	0.2	-0.4	-0.2	-0.1
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.0	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.1	-0.4	0.2
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.1	-0.1	-0.0
Pulse wave peak to peak time	0.0	0.0	0.1	-0.2	0.1	-0.2
Age at last live birth	0.0	0.0	0.1	0.1	0.3	-0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.0	0.1
Medication: Aspirin	0.0	0.0	0.1	-0.2	-0.0	0.2
Smoking status: Current	0.0	0.1	0.1	-0.3	-0.2	-0.2

Hub : Genes

EPHX4

Models

Trait associations