Best TWAS P=1.58e-74 · Best GWAS P=5.05e-97 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SEC61A2 | 0.13 | 0.09 | lasso | 9 | 0.08 | 7.8e-10 | 6.4 | 6.3 | 3.2e-10 | -0.18 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Lung | CAMK1D | 0.28 | 0.24 | enet | 25 | 0.24 | 2.3e-18 | -13.1 | -12.7 | 3.4e-37 | 0.50 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Nerve Tibial | SEC61A2 | 0.21 | 0.10 | enet | 25 | 0.15 | 1.6e-10 | -3.3 | 5.4 | 7.8e-08 | -0.10 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | NUDT5 | 0.20 | 0.01 | enet | 41 | 0.06 | 1.8e-05 | -20.3 | 8.6 | 8.0e-18 | -0.54 | 0.04 | 0.91 | FALSE |
| 5 | GTEx | Whole Blood | CAMK1D | 0.14 | 0.01 | enet | 26 | 0.04 | 2.5e-04 | -13.1 | -13.7 | 5.3e-43 | 0.62 | 0.16 | 0.79 | FALSE |
| 6 | NTR | Blood | CAMK1D | 0.10 | 0.09 | bslmm | 900 | 0.08 | 4.4e-25 | -13.1 | -14.4 | 8.9e-47 | 0.58 | 1.00 | 0.00 | FALSE |
| 7 | NTR | Blood | CDC123 | 0.06 | 0.04 | bslmm | 537 | 0.04 | 4.7e-14 | -20.6 | -18.3 | 1.6e-74 | 0.89 | 0.02 | 0.98 | TRUE |
| 8 | NTR | Blood | SEC61A2 | 0.03 | 0.00 | bslmm | 549 | 0.01 | 1.8e-04 | -3.3 | -10.3 | 5.4e-25 | 0.51 | 0.14 | 0.44 | FALSE |
| 9 | YFS | Blood | CAMK1D | 0.27 | 0.23 | bslmm | 875 | 0.26 | 7.7e-86 | -13.1 | -15.4 | 1.2e-53 | 0.61 | 1.00 | 0.00 | TRUE |
| 10 | YFS | Blood | CDC123 | 0.08 | 0.03 | enet | 35 | 0.06 | 9.6e-19 | -13.1 | -15.0 | 7.3e-51 | 0.65 | 0.44 | 0.56 | FALSE |
| 11 | YFS | Blood | NUDT5 | 0.13 | 0.12 | enet | 40 | 0.13 | 1.1e-41 | -13.1 | -16.3 | 1.9e-59 | 0.68 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SEC61A2 | 0.03 | 0.02 | blup | 59 | 0.03 | 5.2e-04 | -5.4 | 6.5 | 9.1e-11 | -0.19 | 0.23 | 0.02 | FALSE |
| 13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDC123 | 0.26 | 0.07 | lasso | 4 | 0.07 | 1.4e-03 | -12.8 | 15.5 | 1.8e-54 | -0.63 | 0.11 | 0.12 | TRUE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NUDT5 | 0.13 | -0.01 | blup | 55 | 0.01 | 1.1e-01 | -6.7 | -14.0 | 1.3e-44 | 0.50 | 0.01 | 0.18 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT5 | 0.03 | 0.04 | enet | 2 | 0.02 | 2.2e-03 | -5.4 | -5.7 | 1.4e-08 | 0.14 | 0.26 | 0.03 | TRUE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDC123 | 0.08 | 0.00 | blup | 64 | 0.03 | 4.0e-03 | -3.0 | -14.2 | 7.8e-46 | 0.60 | 0.01 | 0.07 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUDT5 | 0.08 | 0.07 | enet | 8 | 0.07 | 8.2e-05 | -3.2 | -12.1 | 7.2e-34 | 0.49 | 0.80 | 0.08 | TRUE |