Hub : Genes

CAMK1D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.2765	0.0620	4.4e-05	0.241	NA	0.240	NA	0.223	1.8e-18	NA	2.3e-18	NA	5.4e-17
2	GTEx	Whole Blood	0.1380	0.0490	6.8e-03	0.013	NA	0.037	NA	0.035	1.9e-02	NA	2.5e-04	NA	3.3e-04
3	METSIM	Adipose	0.1153	0.0354	2.3e-04	0.071	0.029	0.075	0.070	0.071	8.8e-11	3.3e-05	2.2e-11	1.0e-10	7.4e-11
4	NTR	Blood	0.0998	0.0171	2.6e-14	0.086	0.052	0.073	0.082	0.081	2.3e-26	2.1e-16	2.2e-22	4.4e-25	7.4e-25
5	YFS	Blood	0.2682	0.0259	0.0e+00	0.231	0.210	0.261	0.263	0.253	4.2e-74	7.2e-67	3.4e-85	7.7e-86	3.6e-82
6	TCGA	Breast Invasive Carcinoma	0.0435	0.0177	8.0e-03	-0.001	0.013	0.011	NA	-0.001	7.6e-01	8.5e-04	2.1e-03	NA	5.4e-01
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0655	0.0291	8.3e-03	-0.001	0.003	0.000	NA	0.003	5.2e-01	1.2e-01	3.3e-01	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	2.0	-1.2	-1.2	0.1	-1.4	-1.3	-0.1	-1.3
Bipolar Disorder or Schizophrenia	1.5	3.6	7.0	-2.7	-1.8	-0.2	-2.6	-2.6	0.7	-0.7
Depressed Affect (Nagel 2018)	0.5	1.1	5.5	-0.1	0.0	-1.1	0.6	-0.0	0.9	-2.4
Depression (Nagel 2018)	0.6	0.9	3.8	-0.3	0.3	-1.9	0.4	-0.1	1.4	-0.7
Intelligence (Savage-Jansen 2018)	1.1	3.4	16.4	0.3	0.4	0.4	-0.2	-0.2	2.6	4.1
Neuroticism (Nagel 2018)	0.4	1.1	6.1	-0.1	0.2	-0.9	0.2	-0.3	0.5	-2.5
Schizophrenia (2018)	1.3	2.7	5.7	-2.4	-1.3	-0.4	-2.2	-2.3	1.0	0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	3.0	0.5	0.3	-1.7	0.5	0.2	0.2	0.8
Worry (Nagel 2018)	0.3	0.6	3.8	0.3	-0.0	0.1	0.4	-0.1	0.2	-2.0
Alzheimer’s Disease (in mother)	0.6	0.6	1.6	-0.8	-1.2	-0.3	-0.9	-0.7	0.8	0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.1	1.1	1.4	0.2	1.4	1.1	-0.7	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	0.1	0.1	-0.9	0.2	0.1	-0.2	-0.5
Crohns Disease (2017)	0.7	1.6	4.9	0.5	0.8	-2.2	0.1	0.4	0.8	-2.2
Irritable Bowel Disease (IBD)	0.2	0.6	2.0	-0.5	-0.1	-0.2	-0.4	0.0	1.3	-1.4
Ulcerative Colitis (UC)	0.4	0.8	2.0	-1.2	-0.6	1.4	-0.7	-0.2	1.0	-0.2
Major Depression (MDD)	1.6	2.0	5.5	-1.7	-0.8	-0.6	-1.6	-2.3	-0.7	-1.3
Reaction Time	0.7	1.3	4.0	-1.0	-0.2	2.0	-0.6	-0.1	-1.5	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	12.5	0.1	0.1	-0.6	0.1	0.7	1.6	3.5
Breast Cancer	0.9	2.2	4.6	2.1	0.3	1.4	1.7	2.0	-0.8	1.0
Ovarian Cancer	0.7	1.0	2.6	-0.4	-1.1	-1.2	-0.7	0.0	1.0	1.6
Prostate Cancer	0.2	0.2	0.5	0.4	-0.0	-0.6	-0.3	-0.7	-0.2	-0.6
Age at First Birth	0.4	0.6	1.2	-1.0	0.2	0.7	-1.1	-0.8	0.3	-0.5
Bipolar Disorder (2011)	1.9	1.8	3.2	-1.6	-1.8	0.2	-1.8	-1.6	-0.4	-1.1
Body Mass Index (BMI) (2010)	1.0	1.4	3.1	-1.8	-0.5	-0.3	-1.7	-1.5	-0.8	-0.7
Coronary Artery Disease (CAD)	2.5	3.0	6.8	2.6	1.1	-0.4	2.4	2.2	0.8	1.1
Crohns Disease (2012)	0.7	1.1	2.2	1.2	1.2	-1.5	0.8	0.9	0.0	-1.0
Mean Putamen Volume	0.5	0.5	1.4	0.7	0.6	0.5	1.2	0.6	-0.5	0.7
Fasting Glucose	5.2	6.2	12.1	3.0	3.2	1.0	3.5	3.2	-0.7	0.2
HbA1C	0.9	1.0	1.5	1.2	0.5	1.0	1.2	1.2	0.9	-0.7
HDL Cholesterol	0.2	0.3	1.6	0.2	-0.0	0.1	0.7	0.5	1.3	0.0
LDL Cholesterol	0.3	0.5	1.9	0.1	-1.0	-0.2	-0.5	-0.4	1.4	-0.2
Lupus	0.5	0.8	2.3	0.9	0.8	0.2	1.2	1.5	0.8	-0.4
Neuroticism (2016)	1.1	1.6	3.0	-1.7	-0.8	-0.8	-1.6	-1.3	0.1	-1.6
Primary Biliary Cirrhosis	0.3	0.5	0.8	0.6	0.9	-0.2	0.9	0.7	0.8	0.5
Rheumatoid Arthritis	1.3	1.8	4.1	-0.9	-2.0	-1.0	-1.2	-0.7	2.0	1.1
Schizophrenia (2014)	1.8	3.9	7.6	-2.7	-1.9	-0.9	-2.6	-2.8	1.0	-0.4
Triglycerides	0.1	0.1	0.4	0.5	0.2	-0.6	0.2	0.3	-0.4	-0.3
Type 2 Diabetes (T2D) (2012)	2.7	3.1	6.4	2.5	2.3	1.4	2.0	1.8	-0.0	-0.8
Ulcerative Colitis	0.4	0.5	1.7	-0.8	-0.5	-0.6	-0.7	-0.2	0.7	-1.3
Blood Eosinophil Count	0.1	0.9	2.6	-0.3	0.5	-1.3	-0.8	-1.0	-1.6	0.4
Blood Platelet Count	0.3	3.5	8.2	-0.9	-2.2	-1.0	-1.8	-2.9	-2.0	-1.6
Blood Red Count	0.1	0.5	1.6	0.5	-0.4	-0.1	-0.6	-1.3	0.4	1.1
Blood White Count	0.2	1.2	2.8	-0.9	1.6	-0.3	-0.8	-1.0	-1.7	-0.7
Heel T-Score	0.2	1.6	6.3	-1.2	-0.0	1.6	-0.6	-0.2	-0.4	2.5
BMI	0.1	0.7	2.3	0.4	1.5	-0.2	0.2	-0.1	-1.1	-1.1
Height	0.1	2.8	7.2	1.0	-2.3	2.7	-0.7	-0.2	2.2	0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.8	0.4	0.2	-1.4	0.4	-0.0	0.3	-1.7
Systolic Blood Pressure	2.7	13.7	24.7	5.0	4.3	0.9	4.8	4.5	1.8	2.2
Smoking Status	0.3	0.7	2.0	0.1	-0.2	-1.4	0.1	-0.1	-1.1	-1.4
Allergy or Eczema	0.2	0.5	1.8	-0.2	-0.4	0.2	-1.0	-0.5	-0.0	-1.4
Cardiovascular Disease	1.7	5.8	11.6	3.4	3.0	0.6	3.2	2.8	-0.8	-0.8
Hypothyroidism (self reported)	0.3	0.8	3.6	-0.6	-0.9	0.4	0.0	0.4	-1.9	-0.6
Respiratory disease	0.4	0.9	3.7	0.1	1.1	-1.1	0.2	-0.2	-0.4	-1.9
Type 2 Diabetes (T2D) (2018)	12.8	24.0	53.7	7.3	4.8	-0.1	7.0	6.3	-1.5	0.4
Lung FEV1/FVC ratio	23.3	118.0	237.2	-12.7	-13.7	-3.7	-14.4	-15.4	-2.7	-3.5
Lung FVC	4.8	24.3	45.4	-6.7	-5.6	-1.9	-6.7	-6.5	1.3	0.2
Neuroticism	0.7	1.8	4.6	1.2	1.6	-0.4	1.5	1.1	0.4	-2.1
Chronotype (morning person)	2.3	5.3	8.5	2.7	2.1	0.5	2.9	2.7	-2.2	-2.1
Hair Pigment	0.0	1.1	3.2	1.0	1.2	0.1	1.3	0.7	-0.3	-1.8
Tanning	0.0	0.3	0.7	-0.9	-0.5	-0.4	-0.8	-0.1	0.4	-0.7
Hand grip strength (left)	0.1	0.4	2.2	0.1	0.5	-0.4	0.2	0.3	0.2	-1.5
Number of treatments/medications taken	1.8	3.3	4.5	1.9	1.9	-2.1	2.0	1.9	-0.9	-1.8
Average weekly spirits intake	1.2	1.5	2.6	-1.6	-1.3	-0.7	-1.5	-1.4	-0.0	-1.2
Sensitivity / hurt feelings	1.2	2.0	7.9	0.4	1.8	-0.6	0.5	0.1	-1.4	-2.8
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.0	0.4	1.0	-1.4	0.8	0.5	0.1	-0.6
Hearing difficulty/problems: Yes	1.1	1.7	3.6	0.9	1.8	-0.6	1.4	1.9	0.5	1.2
Relative age of first facial hair	0.4	0.8	4.0	-0.6	-0.6	-2.0	-0.0	-0.5	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	1.1	0.3	-0.5	1.0	0.7	-0.9	-0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.9	1.7	0.4	0.9	1.3	0.7	0.4	-0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	0.8	1.1	0.4	1.0	0.3	-0.1	-1.1
Systolic blood pressure, automated reading	5.3	15.4	27.8	5.3	4.6	0.7	5.1	4.6	2.5	2.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.6	0.8	-0.7	-0.4	0.6	0.2	0.0	0.2
Angina	2.1	2.8	5.4	1.8	2.3	0.2	2.1	2.2	-1.2	-0.5
Medication for hormone replacement therapy	1.0	1.2	3.0	-0.6	-1.1	0.6	-0.6	-0.5	1.6	1.7
Vitamin and mineral supplements	0.5	0.7	2.1	-0.2	0.7	0.8	-0.1	-0.0	-1.3	1.4
Supplements: Zinc	2.4	2.6	6.4	-1.9	-2.5	-0.0	-1.9	-2.0	0.7	-0.5
Medication: Co-codamol	0.8	1.0	2.1	0.8	1.2	0.6	0.8	1.3	0.3	-1.4
Medication: Metformin	11.1	15.7	33.1	5.8	4.2	-0.7	5.4	5.1	-1.5	-1.0
Diabetes (father)	1.3	1.6	5.1	2.2	0.6	-0.9	1.8	1.2	0.0	-0.5
Diabetes (mother)	15.3	19.5	37.1	6.1	5.5	-0.3	5.9	5.7	-1.2	0.3
Severe depression (siblings)	0.7	0.7	2.8	0.6	0.5	0.6	0.2	0.1	-1.7	-1.2
Pack years adult smoking proportion	0.8	1.2	4.5	0.1	0.7	-0.4	0.2	-0.3	-1.8	-2.1
Impedance of leg (right)	0.3	1.5	2.7	0.1	-1.5	0.7	-0.8	-1.4	1.6	-1.6
Leg fat-free mass (left)	0.2	1.2	1.9	1.3	1.1	0.8	0.9	1.3	0.1	1.4
Trunk fat percentage	0.2	0.8	2.0	1.2	1.0	-0.2	0.3	0.1	1.4	-1.0
Hand grip strength (right)	0.2	0.5	1.4	0.4	0.5	-0.3	0.3	0.6	1.2	-1.1
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.0	-0.2	-1.1	-0.3	-0.2	1.1	0.7
Current tobacco smoking	0.4	0.6	1.8	0.5	0.2	-0.5	0.6	0.6	-1.2	-1.4
Average weekly fortified wine intake	0.6	0.8	2.7	-0.5	0.1	0.8	-0.7	-0.4	1.6	1.0
Maternal smoking around birth	0.3	0.4	0.7	-0.8	-0.3	0.6	-0.6	-0.4	0.4	-0.9
Fed-up feelings	1.2	2.2	4.5	1.7	1.1	-1.4	2.1	1.6	0.0	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.7	-1.0	-0.7	-1.9	-0.4	-0.9	0.3	-0.1
Relative age voice broke	0.5	0.8	4.5	-0.6	-0.2	-2.1	-0.3	-0.8	0.1	0.4
Taking other prescription medications	0.8	1.2	3.1	-0.0	-0.1	-1.6	0.0	-0.2	-1.6	-1.8
Age when periods started (menarche)	0.5	1.2	2.6	1.1	0.6	-1.3	1.6	0.9	-1.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	0.7	-0.2	0.7	1.0	0.7	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.3	0.6	1.5	-0.4	1.6	1.8	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.0	1.4	0.9	0.8	0.8	1.1	0.7	0.2
Qualifications: CSEs or equivalent	0.7	1.0	1.9	1.1	1.4	0.4	1.4	1.2	0.3	-0.3
Serious illness, injury or assault to yourself	0.9	1.1	3.2	1.8	0.3	-0.3	1.2	0.8	-1.2	-0.8
High blood pressure	2.6	7.4	13.2	3.6	3.6	0.7	3.6	3.2	-0.9	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.6	-0.1	-0.4	0.3	-0.7	-0.4	-0.8	-1.6
Multivitamins +/- minerals	0.7	0.9	2.1	-0.5	-1.1	0.4	-0.6	-0.7	1.3	-1.4
Stomach or abdominal pain in last month	0.5	0.6	2.2	0.2	-0.6	0.1	0.0	0.0	-1.5	-1.2
Supplements: Glucosamine	0.1	0.1	0.6	-0.4	0.2	-0.4	-0.0	0.1	-0.2	-0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.6	-1.5	-1.6	0.9	-1.6	-1.4	0.2	-0.4
Medication: Atenolol	1.8	2.2	4.5	1.3	1.3	0.3	1.4	2.1	1.9	1.3
Medication: Levothyroxine sodium	0.6	1.0	3.2	0.4	0.4	0.2	1.3	1.1	-1.8	-0.4
Sitting height	0.2	1.5	4.9	-0.0	-1.0	1.9	-0.7	-0.2	0.8	2.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.4	0.2	-0.9	-0.4	-0.2	0.9	0.6
High blood pressure (mother)	1.5	2.0	4.1	2.0	1.9	1.0	1.6	1.4	-0.4	0.8
Body mass index (BMI)	0.5	2.2	7.3	1.5	2.7	-0.5	1.5	1.4	-0.5	-0.9
Impedance of leg (left)	0.4	1.8	3.7	-0.3	-1.9	0.5	-1.2	-1.7	1.4	-1.5
Leg predicted mass (left)	0.2	1.1	1.7	1.3	1.0	1.0	0.9	1.3	0.1	1.3
Trunk fat mass	0.2	0.9	2.3	1.5	1.2	0.1	0.7	0.6	1.2	-0.7
Waist circumference	0.5	1.8	4.7	1.7	2.2	-0.2	1.3	1.1	-0.1	-1.4
Number of incorrect matches in round	1.1	1.8	4.7	-1.0	-0.2	-0.3	-1.2	-1.2	-2.0	-2.2
Past tobacco smoking	0.3	0.5	1.3	-0.3	-0.4	1.1	-0.0	0.4	1.1	0.6
Alcohol usually taken with meals	1.1	1.8	4.0	-1.2	-2.0	0.0	-1.3	-0.9	-1.4	1.6
Nervous feelings	0.4	0.8	3.1	1.1	0.3	-0.6	0.9	0.0	1.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.6	0.4	0.0	-1.1	0.8	0.1	-0.5	-1.6
Hearing difficulty/problems with background noise	1.6	2.6	5.8	1.1	1.6	-1.3	1.5	2.1	0.3	2.4
Hair/balding pattern: Pattern 2	0.9	1.1	3.7	-0.7	-1.2	0.6	-1.0	-0.7	0.4	1.9
Had menopause	0.6	0.8	1.6	1.1	1.0	1.3	1.2	0.4	0.1	0.2
Had other major operations	0.1	0.2	0.6	0.1	0.4	-0.7	-0.0	-0.1	0.5	0.5
Forced vital capacity (FVC)	3.5	13.4	24.9	-4.8	-4.7	-1.1	-5.0	-4.8	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.5	1.1	1.7	0.6	1.8	2.1	0.6	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.1	-0.1	0.6	-1.8	0.5	0.2	0.6	-1.5
Qualifications: None of the above	1.3	2.9	14.3	-0.5	0.5	0.1	-0.2	-0.5	-2.3	-3.8
Financial difficulties in last 2 years	1.0	1.3	2.5	-1.6	-0.5	0.5	-1.5	-1.3	-1.0	-1.0
Mouth/teeth dental problems	1.2	1.8	3.3	-1.8	-1.4	0.2	-1.8	-1.8	-0.9	-0.2
Heart attack	1.9	2.4	4.2	1.8	2.0	0.8	1.9	2.0	1.2	0.0
Allergy	0.1	0.3	1.5	-0.0	-0.3	0.2	0.3	0.7	0.0	1.2
Pain all over the body in last month	1.3	1.4	5.3	0.7	1.1	0.6	0.5	0.8	-2.3	-1.4
Diabetes (self-reported)	6.9	10.6	24.2	4.9	3.1	-0.7	4.6	4.1	-1.3	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.2	-0.4	-0.8	-0.8	-0.2	-0.7	0.0
Medication: Ramipril	3.6	4.7	9.2	2.8	2.4	-1.3	2.9	3.0	0.3	0.1
Medication: Simvastatin	4.1	6.0	11.7	3.2	3.4	-0.9	3.2	2.9	0.6	-0.6
Fluid intelligence score	0.5	1.1	5.4	0.0	-0.6	-0.2	0.1	0.5	1.3	2.3
Illnesses of siblings	1.9	2.7	6.5	-1.8	-2.5	-0.3	-1.9	-1.5	-0.1	1.8
Neuroticism score	0.4	0.8	2.0	0.9	1.0	-0.2	1.0	0.7	0.7	-1.4
Weight	0.2	1.2	2.6	1.6	1.6	0.5	1.1	1.3	0.3	-0.0
Impedance of arm (right)	0.6	2.9	7.0	-0.9	-2.6	-1.0	-2.0	-1.9	2.0	0.1
Arm fat percentage (right)	0.3	1.0	3.1	1.2	1.8	-0.8	0.6	0.5	0.7	-0.9
Trunk fat-free mass	0.3	2.0	3.6	1.7	1.2	1.6	1.6	1.9	-0.0	0.8
Hip circumference	0.2	0.7	1.6	1.2	1.3	0.4	0.7	0.9	0.0	-0.1
Time employed in main current job	2.3	2.7	9.2	0.1	-0.4	-2.2	0.3	0.8	3.0	2.0
Alcohol intake versus 10 years previously	2.1	3.1	8.4	2.1	2.9	0.3	1.8	1.8	1.1	-1.0
Father’s age at death	0.2	0.3	1.0	1.0	-0.0	-0.3	0.8	0.0	-0.7	-0.2
Worrier / anxious feelings	0.1	0.2	1.3	0.0	-0.3	0.2	0.1	-0.0	1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	0.6	0.7	-0.1	0.8	0.3	-1.4	-1.5
Falls in the last year	0.5	0.7	3.3	0.2	-0.9	-0.3	-0.2	-0.6	-0.4	-1.8
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-0.6	-0.4	-1.1	-0.6	-0.7	0.4	-0.3
Number of live births	0.6	0.9	2.3	-0.0	0.6	-0.9	-0.2	-0.5	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1)	11.4	38.5	71.2	-7.8	-8.0	-1.8	-8.3	-8.4	-0.8	-0.7
Pulse rate	3.4	5.7	10.1	-2.8	-2.6	-0.2	-3.2	-3.0	1.2	2.0
Happiness	0.1	0.2	0.4	-0.2	-0.5	0.4	-0.2	-0.5	0.6	0.3
Noisy workplace	0.4	0.5	1.6	0.1	1.1	-1.3	0.1	-0.1	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.7	-0.4	0.1	2.2	-0.5	0.0	-1.3	2.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.8	0.2	-0.9	-0.5	0.2	0.0	1.3	-0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.1	0.3	0.8	-1.4	0.9	1.0	1.2	-1.0
Asthma	0.2	0.5	1.5	-0.3	0.6	-1.2	0.0	-0.4	0.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	-0.1	-0.8	-0.6	-0.7	0.3	-0.4	-0.1
Medication: Cholesterol lowering	3.7	5.8	10.8	3.0	3.3	0.6	3.2	3.1	0.2	-0.7
Depression (self-reported)	0.7	0.8	1.6	0.6	0.4	-1.1	0.9	0.7	-1.0	-1.3
Medication: Lansoprazole	1.1	1.3	3.5	0.5	0.0	-0.6	-0.5	-1.2	-1.8	-1.9
Prospective memory result	0.2	0.2	0.9	0.1	-0.9	-0.2	-0.2	-0.2	0.5	0.5
Lung cancer (father)	0.8	0.9	2.2	-1.3	-1.5	0.0	-0.8	-0.9	-0.9	-0.1
Illnesses of mother	1.9	2.4	6.0	-1.5	-2.5	0.2	-1.8	-1.7	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	10.9	34.8	65.5	-7.5	-7.5	-0.8	-8.0	-8.1	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	0.2	0.2	0.6	-0.2	-0.2	-0.3	-0.7
Impedance of arm (left)	1.0	4.4	9.5	-1.3	-3.1	-1.1	-2.4	-2.3	2.6	0.6
Arm fat mass (right)	0.3	1.1	3.0	1.4	1.7	-0.2	1.0	0.9	0.3	-0.7
Trunk predicted mass	0.4	2.1	3.8	1.8	1.3	1.7	1.6	2.0	-0.0	0.8
Standing height	0.2	2.3	5.4	0.5	-2.2	2.3	-0.6	-0.0	1.6	1.6
Length of working week for main job	1.1	1.2	2.9	-1.0	-0.9	1.1	-1.6	-1.7	0.3	-0.2
Exposure to tobacco smoke at home	0.6	0.6	2.8	0.2	1.7	-0.2	0.8	0.6	-0.6	-0.3
Breastfed as a baby	0.7	0.9	2.4	0.5	1.0	0.3	0.7	0.7	-1.2	-1.5
Tense / ‘highly strung’	0.3	0.5	2.7	0.3	0.4	-0.3	0.0	-0.3	0.7	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.9	0.2	-0.2	-0.9	0.6	0.5	0.3	-1.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.7	-0.5	0.0	-0.3	-0.7	-0.1	-0.6
Birth weight of first child	0.5	1.0	2.9	1.4	-0.4	-0.2	0.9	1.0	0.4	1.7
Peak expiratory flow (PEF)	8.5	19.7	39.2	-5.4	-5.5	-1.1	-6.1	-6.3	-0.7	-1.0
Pulse wave reflection index	1.1	1.3	4.0	0.3	1.0	0.6	0.6	0.8	-1.6	-2.0
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.6	0.9	1.6	-1.3	1.1	1.2	-0.9	-1.5
Loud music exposure frequency	0.9	1.0	2.2	-1.1	-0.9	-0.3	-1.0	-1.5	0.4	-1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.8	-0.7	-0.6	1.3	-0.5	-0.1	-0.3	-0.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.3	1.8	1.4	-0.5	1.5	1.2	0.8	1.0
Blood clot in the leg (DVT)	0.4	0.5	1.7	0.6	0.6	-1.3	0.2	0.0	-0.8	-0.5
Medication: Paracetamol	0.9	1.5	3.6	1.2	0.7	-1.2	0.9	0.7	-1.5	-1.9
Headache pain in last month	0.7	1.3	2.4	-1.6	-1.0	-0.2	-1.4	-1.1	0.1	-1.5
Medication for cholesterol, blood pressure or diabetes	6.7	11.2	20.0	-4.3	-4.4	-1.2	-4.3	-4.5	-0.5	-0.3
Glaucoma (self-reported)	0.5	0.6	1.9	-0.5	-1.4	-0.2	-0.3	-0.3	-0.9	-0.9
Gout (self-reported)	0.4	0.5	1.8	-0.1	0.2	0.3	-0.4	-0.3	1.4	1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.5	0.1	-0.6	0.3	0.7	0.8	-1.9	-0.4
Medication: Amlodipine	1.1	1.5	3.7	1.5	1.9	-0.2	1.1	1.5	-0.5	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.3	0.1	0.9	-0.8	0.2	-0.2	-1.1	-1.5
Birth weight	0.9	1.9	4.0	0.6	1.5	0.8	1.2	2.0	1.7	1.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.1	-1.8	-0.2	-0.5	-1.6	-1.7	0.2	-0.0
High blood pressure (siblings)	0.5	0.7	3.3	0.0	1.0	-0.5	0.4	-0.3	-0.5	-1.8
Forced vital capacity (FVC), Best measure	3.0	11.0	20.9	-4.4	-4.2	-0.3	-4.6	-4.3	0.2	0.6
Body fat percentage	0.3	1.3	2.9	1.5	1.7	-0.2	0.8	0.6	1.4	-0.9
Leg fat percentage (right)	0.8	2.7	6.0	2.2	2.4	-0.3	1.7	1.3	0.9	-1.7
Arm fat-free mass (right)	0.4	2.2	4.8	1.7	1.4	2.2	1.5	1.6	0.1	1.1
Exposure to tobacco smoke outside home	0.5	0.6	2.0	0.2	0.3	-0.7	0.4	0.9	-0.9	1.4
Comparative body size at age 10	0.8	2.1	4.7	1.3	2.1	0.0	1.5	2.2	1.3	0.2
Number of full brothers	0.3	0.4	2.1	-0.2	-0.5	-0.2	-0.1	0.1	-1.5	-0.2
Worry too long after embarrassment	0.3	0.5	2.0	0.5	0.9	1.4	0.4	0.2	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.3	-0.1	0.5	0.3	-0.1	0.8	0.4
Wheeze or whistling in the chest in last year	1.3	2.3	4.3	1.8	2.1	-0.4	1.9	2.1	-0.6	-0.2
Number of children fathered	1.0	1.1	3.3	-0.8	-1.4	0.2	-0.7	-1.0	1.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.9	1.9	1.2	1.2	2.0	1.5	-0.2	0.6
Age at first live birth	0.3	0.5	1.8	-0.7	-0.4	-0.4	-0.4	-0.5	-1.3	-0.6
Pulse wave peak to peak time	0.2	0.2	0.9	-0.1	-0.2	-0.0	0.3	0.3	0.4	1.0
Health satisfaction	0.5	0.7	1.7	0.7	1.3	-1.2	0.9	0.3	0.5	0.0
Shortness of breath walking on level ground	0.4	0.5	2.1	-0.3	-0.1	-0.7	-0.6	-0.8	-0.4	-1.4
Qualifications: College or University degree	0.9	3.0	9.1	-1.5	-1.8	0.3	-1.5	-1.4	1.4	3.0
Eye problems/disorders: None of the above	0.5	0.6	2.6	0.2	0.8	0.2	0.1	0.0	0.9	1.6
Mouth/teeth dental problems: Loose teeth	2.9	3.4	5.3	2.2	2.1	2.0	2.3	2.2	-0.7	0.5
Emphysema/chronic bronchitis	0.3	0.3	1.4	0.4	0.3	0.1	0.6	0.3	1.2	0.4
Medication for pain relief, constipation, heartburn	1.2	2.0	5.1	-0.8	-1.3	0.8	-0.7	-0.9	2.1	2.2
Neck or shoulder pain in last month	1.6	2.2	3.5	1.9	1.5	-0.7	1.9	1.1	-1.8	-1.2
Medication: Blood pressure	5.1	9.0	15.9	4.0	3.9	1.0	3.8	4.0	0.3	0.5
Angina (self-reported)	2.5	3.3	6.3	2.0	2.5	0.3	2.3	2.4	-1.2	-0.7
Migraine (self-reported)	0.5	0.6	1.1	0.8	1.0	-0.1	0.0	0.7	-1.0	-1.0
Medication: Ibuprofen	0.8	0.9	4.2	-0.4	-0.9	-2.1	-0.8	-0.1	0.7	0.3
Medication: Allopurinol	1.0	1.4	4.1	1.0	0.7	-0.1	0.5	0.4	2.0	1.8
Medication: Omeprazole	2.0	2.4	5.4	-1.7	-2.1	0.3	-2.3	-1.9	0.1	-0.5
Medication: Seretide 50 evohaler	1.4	1.6	5.5	-0.3	1.4	-0.2	0.3	-0.6	-2.3	-1.8
Mean time to correctly identify matches	0.6	1.1	4.0	-0.7	0.7	2.0	-0.0	0.7	-0.6	-1.4
Heart disease (mother)	0.6	0.7	1.4	-1.2	-0.1	0.1	-0.9	-1.1	0.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	6.2	1.0	0.1	-0.4	0.8	0.6	-0.8	-2.5
Whole body fat mass	0.4	1.5	3.3	1.8	1.8	0.2	1.1	1.0	1.1	-0.7
Leg fat mass (right)	0.6	2.2	5.4	2.1	2.3	0.3	1.5	1.4	0.7	-0.9
Arm predicted mass (right)	0.4	1.8	4.7	1.5	1.2	2.2	1.3	1.4	-0.2	0.8
Pulse rate, automated reading	0.4	1.2	2.5	-0.8	-1.5	-0.7	-1.6	-1.4	0.0	0.9
Alcohol intake frequency.	0.9	2.0	3.4	-1.6	-1.3	0.5	-1.7	-1.7	-0.6	-1.8
Comparative height size at age 10	0.4	2.3	6.2	0.0	-1.8	2.5	-0.9	0.2	1.5	1.8
Number of full sisters	0.7	0.8	2.1	0.7	1.5	-0.7	1.4	0.8	0.0	0.1
Suffer from ‘nerves’	0.5	0.7	2.7	-0.5	-0.9	0.7	-0.3	-0.7	-0.6	-1.6
Overall health rating	1.8	3.9	6.1	2.5	1.8	-0.3	2.5	2.5	-1.2	-2.2
Chest pain or discomfort	0.3	0.4	1.4	0.1	1.2	0.5	0.7	0.6	-0.6	-0.4
Had major operations	0.4	0.5	1.7	0.7	0.9	-0.4	0.2	0.4	1.3	0.3
Age at last live birth	0.4	0.5	1.9	-0.5	-0.1	-1.4	-0.2	-0.2	-1.2	-0.0
Family relationship satisfaction	0.2	0.3	0.8	0.7	0.1	0.9	0.4	0.6	0.2	-0.4
Leg pain on walking	1.2	1.5	7.8	0.4	0.3	-2.8	0.6	-0.1	-0.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	5.2	2.1	1.5	-1.2	1.9	2.3	0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.5	0.1	-0.1	-0.1	-0.1	0.8	0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.8	0.9	0.9	0.4	0.7	0.8	-0.8	1.7
Medication: Aspirin	2.3	3.0	6.0	2.2	2.2	0.3	2.4	2.3	-0.3	0.4
Supplements: Vitamin C	0.1	0.1	0.3	0.2	-0.6	-0.4	0.2	0.0	0.3	-0.1
Knee pain experienced in last month	0.7	1.0	5.7	-0.4	0.5	-0.8	-0.2	-0.1	-0.7	-2.4
Hypertension (Self-reported)	2.7	7.6	14.0	3.5	3.7	1.0	3.7	3.4	-0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	5.6	-1.6	-2.1	-0.3	-2.4	-2.1	-1.5	-0.8
Illnesses of father: Heart disease	2.7	3.7	6.6	2.4	2.3	0.6	2.6	2.4	1.1	-1.0
Illnesses of siblings: Diabetes	9.6	11.8	26.8	5.2	3.5	2.6	4.4	4.1	0.3	-0.7
Smoking status: Previous	0.3	0.4	1.2	-0.2	-0.5	-1.1	-0.6	-1.0	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.1	-0.6	-1.2	1.8	-1.0	-0.4	0.3	0.6
Whole body fat-free mass	0.3	1.9	3.3	1.7	1.3	1.5	1.4	1.8	0.0	1.1
Leg fat-free mass (right)	0.2	0.9	2.3	1.0	0.7	0.8	0.6	1.1	-0.1	1.5
Arm fat percentage (left)	0.2	0.8	2.4	1.0	1.5	-0.7	0.5	0.4	0.9	-0.5
Average weekly red wine intake	0.2	0.3	1.1	0.5	-0.8	0.1	0.0	-0.1	-1.1	-0.2
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.4	0.8	1.1	-0.0	1.0	1.1	-1.6	-2.3
Mood swings	0.5	0.8	1.9	0.6	0.6	-0.7	0.7	0.7	1.3	-1.4
Loneliness, isolation	0.3	0.5	2.7	-0.4	-0.4	-0.2	0.3	0.1	-0.2	-1.6
Long-standing illness, disability or infirmity	2.0	3.1	6.4	2.5	1.4	-0.5	2.1	1.8	-0.9	-2.0
Ever had bowel cancer screening	0.9	1.0	3.0	0.8	0.3	1.4	1.1	1.7	-0.0	-0.1
Diabetes diagnosed by doctor	7.5	12.3	28.6	5.3	3.2	-0.8	5.1	4.4	-1.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.8	0.8	1.7	0.6	1.4	0.7	1.5	1.3
Friendships satisfaction	0.8	1.0	2.2	0.9	0.7	1.5	0.9	1.4	-0.3	0.6
Qualifications: nursing, teaching	2.0	3.0	4.0	-1.7	-1.8	0.5	-2.0	-1.9	1.8	2.0
Commuting to job workplace: Walk	0.3	0.3	1.6	-0.3	0.2	0.2	-0.1	-0.3	-1.3	-0.5
Eye problems/disorders: Cataract	1.3	1.5	2.9	-1.4	-1.7	-0.0	-1.2	-1.0	-0.7	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.4	2.3	1.2	1.4	1.6	1.9	0.3	0.5
Medication for cholesterol	0.1	0.1	0.8	0.0	0.0	0.9	0.0	0.1	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	-0.3	1.5	-1.0	0.4	0.3	-1.2	-0.3
Back pain experienced in last month	0.6	0.9	3.0	0.1	-0.1	0.5	0.2	-0.2	-1.7	-1.7
Mineral and other dietary supplements	0.8	1.0	4.6	1.0	1.0	0.5	0.3	0.6	-2.1	-0.2
Breast cancer (self-reported)	1.3	1.6	3.8	1.1	1.4	-2.0	1.1	1.1	-0.6	1.1
Asthma (self-reported)	0.3	0.6	1.8	-0.0	0.9	-1.3	0.2	-0.2	0.1	-1.3
Osteoporosis (self-reported)	0.1	0.1	0.3	0.3	-0.5	-0.5	0.1	0.0	-0.2	0.0
Osteoarthritis (self-reported)	0.6	0.7	2.7	-0.1	-0.1	-1.3	-0.5	-0.8	0.0	-1.7
Medication: Aspirin	2.6	3.4	7.0	2.4	2.2	0.4	2.6	2.5	-0.1	0.4
Medication: Gliclazide	3.2	3.7	9.0	3.0	1.7	-1.3	2.8	2.1	0.5	-0.0
Illnesses of father: None of the above (group 1)	4.4	5.5	12.7	-3.6	-2.3	0.9	-3.1	-2.5	-1.6	0.8
Smoking status: Current	0.4	0.7	2.0	0.3	0.3	-0.6	0.5	0.5	-1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.9	18.9	36.7	-5.6	-5.3	-2.0	-5.6	-6.1	-0.0	-0.0
Whole body water mass	0.3	1.8	3.0	1.6	1.2	1.6	1.4	1.7	-0.1	1.1
Leg predicted mass (right)	0.2	0.8	2.4	0.9	0.7	0.8	0.6	1.1	-0.1	1.5
Arm fat mass (left)	0.2	1.0	3.0	1.4	1.7	0.0	0.9	0.9	0.5	-0.6
Number of self-reported non-cancer illnesses	1.8	3.2	4.9	1.8	1.9	-0.3	1.8	1.6	-2.2	-2.2
Average weekly champagne plus white wine intake	1.1	1.5	3.2	-1.3	-1.8	-1.0	-1.7	-0.9	-0.1	0.8
Miserableness	0.6	1.0	6.3	-0.5	0.4	-0.3	0.2	0.1	-0.5	-2.5
Guilty feelings	0.7	1.0	2.4	-0.9	-0.6	0.7	-1.2	-1.2	-0.2	1.5
Wears glasses or contact lenses	1.9	2.2	6.3	1.2	0.5	-0.8	1.5	1.8	2.5	-1.2
Ever taken oral contraceptive pill	0.6	0.7	1.9	-1.1	0.5	-0.8	-0.2	-0.4	-0.8	-1.4
Hearing aid user	0.5	0.6	1.0	0.5	0.9	-1.0	0.6	0.7	0.9	0.5
Mother’s age at death	0.8	1.0	2.3	1.3	1.0	0.8	1.0	1.5	-0.1	0.0
Financial situation satisfaction	0.3	0.3	1.3	-0.8	-0.1	0.5	-0.1	-0.2	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.1	-0.2	-0.4	-0.1	0.4	0.4	-0.6
Commuting to job workplace: Public transport	0.6	0.8	2.5	0.7	0.2	0.7	0.8	0.8	-1.6	-0.7
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	-0.1	-0.7	-0.2	0.1	0.1	-0.9	-1.1
Medication: Blood pressure	0.3	0.6	1.0	0.7	0.9	-0.6	1.0	0.7	-0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.2	1.2	1.3	0.5	0.7	0.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.8	0.1	-0.3	-0.1	0.8	0.4	2.2	-0.9
High cholesterol (Self-reported)	2.2	3.9	7.6	2.3	2.8	-0.3	2.6	2.6	0.9	0.2
Medication: Bendroflumethiazide	1.0	1.6	3.5	1.4	1.6	-0.5	1.9	1.6	-0.6	0.2
Medication: Paracetamol	1.2	1.9	3.7	1.6	1.4	-1.2	1.5	1.0	-0.7	-1.9
Medication: Lisinopril	1.4	1.9	7.7	1.1	2.8	-0.1	1.3	1.3	0.8	0.3
Medication: Atorvastatin	1.5	1.8	4.3	1.4	1.9	0.1	1.5	2.1	-0.1	-0.5
Illnesses of father: High blood pressure	2.4	2.9	7.3	2.7	1.8	0.8	2.2	1.6	0.0	-1.4
Alcohol drinker status: Never	1.0	1.3	3.7	0.5	-0.4	1.9	0.7	0.9	0.3	-1.8
Ever smoked	0.4	0.7	2.9	0.7	0.7	-0.9	0.6	0.1	-1.7	-0.5
Basal metabolic rate	0.3	1.5	2.6	1.6	1.3	1.2	1.3	1.6	0.1	0.8
Leg fat percentage (left)	0.6	2.1	4.6	1.9	2.1	-0.6	1.4	1.0	0.6	-1.7
Arm fat-free mass (left)	0.4	1.9	2.9	1.7	1.5	1.6	1.5	1.7	-0.3	0.5
Number of operations (self-reported)	0.8	1.2	2.2	1.4	1.3	-1.5	1.1	0.7	0.8	0.4
Average weekly beer plus cider intake	1.6	2.3	4.2	1.5	1.5	2.1	1.5	1.4	1.5	-0.9
Irritability	1.5	2.5	7.2	1.2	0.6	-2.7	1.1	1.5	2.1	0.6
Risk taking	1.0	1.5	5.0	-1.2	-2.2	0.2	-1.4	-1.1	-0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.4	1.2	0.8	-0.1	1.0	0.8	0.2	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	2.7	-0.4	-1.7	-1.0	-0.6	-0.6	0.9	0.4
Age started oral contraceptive pill	0.1	0.1	0.4	0.3	-0.1	-0.5	0.2	-0.2	0.6	0.3
Diastolic blood pressure, automated reading	0.7	2.1	4.4	1.5	1.7	0.1	1.4	1.4	1.3	2.1
Ever depressed for a whole week	0.5	0.6	2.3	0.9	0.5	-1.5	0.8	0.6	-0.2	-0.0
Unable to work because of sickness or disability	0.4	0.6	2.2	0.2	0.3	-0.2	0.5	0.5	-1.0	-1.5
Commuting to job workplace: Cycle	1.6	1.9	5.1	1.8	0.9	-0.2	1.8	2.3	-0.3	1.1
Myopia	0.2	0.2	0.7	-0.3	-0.0	0.8	0.4	0.6	-0.3	-0.4
Vascular/heart problems diagnosed by doctor	2.3	6.2	11.1	-3.3	-3.3	-1.0	-3.3	-3.0	0.8	-0.3
Cholesterol lowering medication	1.9	2.8	5.7	1.8	2.4	-1.0	2.2	2.0	-0.7	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	7.2	-2.1	-1.8	0.1	-2.7	-2.3	-0.6	-0.6
Pain experienced in last month	1.2	2.0	6.4	-0.2	-0.9	-0.5	-0.7	-0.6	2.5	2.5
Supplements: Calcium	1.2	1.3	2.6	-1.1	-1.0	-1.6	-1.2	-1.5	0.2	0.6
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	-1.1	-0.5	0.6	-1.3	-1.2	-1.1	0.5
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.8	1.6	1.9	0.6	1.8	1.9	1.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.5	0.7	0.7	-1.6	0.4	0.2	-0.7	-0.1
Heart disease (siblings)	0.6	0.7	2.4	0.0	1.5	1.6	0.2	0.5	0.3	0.2
Alcohol drinker status: Previous	2.0	2.3	5.1	-2.1	-2.2	-0.1	-1.5	-1.8	-0.8	0.1
Pack years of smoking	0.7	1.1	5.0	-0.1	0.7	-0.5	0.0	-0.4	-1.3	-2.2
Impedance of whole body	0.6	3.1	7.0	-0.9	-2.6	-0.2	-2.0	-2.3	2.1	-0.4
Leg fat mass (left)	0.5	1.8	4.4	1.9	2.1	0.1	1.4	1.3	0.6	-0.8
Arm predicted mass (left)	0.4	2.0	4.1	1.6	1.6	2.0	1.4	1.6	-0.3	0.4