Hub : Genes

CAMK1D

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.2765 0.0620 4.4e-05 0.241 NA 0.240 NA 0.223 1.8e-18 NA 2.3e-18 NA 5.4e-17
2 GTEx Whole Blood 0.1380 0.0490 6.8e-03 0.013 NA 0.037 NA 0.035 1.9e-02 NA 2.5e-04 NA 3.3e-04
3 METSIM Adipose 0.1153 0.0354 2.3e-04 0.071 0.029 0.075 0.070 0.071 8.8e-11 3.3e-05 2.2e-11 1.0e-10 7.4e-11
4 NTR Blood 0.0998 0.0171 2.6e-14 0.086 0.052 0.073 0.082 0.081 2.3e-26 2.1e-16 2.2e-22 4.4e-25 7.4e-25
5 YFS Blood 0.2682 0.0259 0.0e+00 0.231 0.210 0.261 0.263 0.253 4.2e-74 7.2e-67 3.4e-85 7.7e-86 3.6e-82
6 TCGA Breast Invasive Carcinoma 0.0435 0.0177 8.0e-03 -0.001 0.013 0.011 NA -0.001 7.6e-01 8.5e-04 2.1e-03 NA 5.4e-01
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0655 0.0291 8.3e-03 -0.001 0.003 0.000 NA 0.003 5.2e-01 1.2e-01 3.3e-01 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.2 2.0 -1.2 -1.2 0.1 -1.4 -1.3 -0.1 -1.3
Bipolar Disorder or Schizophrenia 1.5 3.6 7.0 -2.7 -1.8 -0.2 -2.6 -2.6 0.7 -0.7
Depressed Affect (Nagel 2018) 0.5 1.1 5.5 -0.1 0.0 -1.1 0.6 -0.0 0.9 -2.4
Depression (Nagel 2018) 0.6 0.9 3.8 -0.3 0.3 -1.9 0.4 -0.1 1.4 -0.7
Intelligence (Savage-Jansen 2018) 1.1 3.4 16.4 0.3 0.4 0.4 -0.2 -0.2 2.6 4.1
Neuroticism (Nagel 2018) 0.4 1.1 6.1 -0.1 0.2 -0.9 0.2 -0.3 0.5 -2.5
Schizophrenia (2018) 1.3 2.7 5.7 -2.4 -1.3 -0.4 -2.2 -2.3 1.0 0.2
Schizophrenia vs Biploar Disorder 0.5 0.6 3.0 0.5 0.3 -1.7 0.5 0.2 0.2 0.8
Worry (Nagel 2018) 0.3 0.6 3.8 0.3 -0.0 0.1 0.4 -0.1 0.2 -2.0
Alzheimer’s Disease (in mother) 0.6 0.6 1.6 -0.8 -1.2 -0.3 -0.9 -0.7 0.8 0.2
Alzheimer’s Disease (in father) 1.0 1.1 2.1 1.1 1.4 0.2 1.4 1.1 -0.7 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.2 0.8 0.1 0.1 -0.9 0.2 0.1 -0.2 -0.5
Crohns Disease (2017) 0.7 1.6 4.9 0.5 0.8 -2.2 0.1 0.4 0.8 -2.2
Irritable Bowel Disease (IBD) 0.2 0.6 2.0 -0.5 -0.1 -0.2 -0.4 0.0 1.3 -1.4
Ulcerative Colitis (UC) 0.4 0.8 2.0 -1.2 -0.6 1.4 -0.7 -0.2 1.0 -0.2
Major Depression (MDD) 1.6 2.0 5.5 -1.7 -0.8 -0.6 -1.6 -2.3 -0.7 -1.3
Reaction Time 0.7 1.3 4.0 -1.0 -0.2 2.0 -0.6 -0.1 -1.5 -1.2
Verbal and Numeric Reasoning (VNR) 1.0 2.3 12.5 0.1 0.1 -0.6 0.1 0.7 1.6 3.5
Breast Cancer 0.9 2.2 4.6 2.1 0.3 1.4 1.7 2.0 -0.8 1.0
Ovarian Cancer 0.7 1.0 2.6 -0.4 -1.1 -1.2 -0.7 0.0 1.0 1.6
Prostate Cancer 0.2 0.2 0.5 0.4 -0.0 -0.6 -0.3 -0.7 -0.2 -0.6
Age at First Birth 0.4 0.6 1.2 -1.0 0.2 0.7 -1.1 -0.8 0.3 -0.5
Bipolar Disorder (2011) 1.9 1.8 3.2 -1.6 -1.8 0.2 -1.8 -1.6 -0.4 -1.1
Body Mass Index (BMI) (2010) 1.0 1.4 3.1 -1.8 -0.5 -0.3 -1.7 -1.5 -0.8 -0.7
Coronary Artery Disease (CAD) 2.5 3.0 6.8 2.6 1.1 -0.4 2.4 2.2 0.8 1.1
Crohns Disease (2012) 0.7 1.1 2.2 1.2 1.2 -1.5 0.8 0.9 0.0 -1.0
Mean Putamen Volume 0.5 0.5 1.4 0.7 0.6 0.5 1.2 0.6 -0.5 0.7
Fasting Glucose 5.2 6.2 12.1 3.0 3.2 1.0 3.5 3.2 -0.7 0.2
HbA1C 0.9 1.0 1.5 1.2 0.5 1.0 1.2 1.2 0.9 -0.7
HDL Cholesterol 0.2 0.3 1.6 0.2 -0.0 0.1 0.7 0.5 1.3 0.0
LDL Cholesterol 0.3 0.5 1.9 0.1 -1.0 -0.2 -0.5 -0.4 1.4 -0.2
Lupus 0.5 0.8 2.3 0.9 0.8 0.2 1.2 1.5 0.8 -0.4
Neuroticism (2016) 1.1 1.6 3.0 -1.7 -0.8 -0.8 -1.6 -1.3 0.1 -1.6
Primary Biliary Cirrhosis 0.3 0.5 0.8 0.6 0.9 -0.2 0.9 0.7 0.8 0.5
Rheumatoid Arthritis 1.3 1.8 4.1 -0.9 -2.0 -1.0 -1.2 -0.7 2.0 1.1
Schizophrenia (2014) 1.8 3.9 7.6 -2.7 -1.9 -0.9 -2.6 -2.8 1.0 -0.4
Triglycerides 0.1 0.1 0.4 0.5 0.2 -0.6 0.2 0.3 -0.4 -0.3
Type 2 Diabetes (T2D) (2012) 2.7 3.1 6.4 2.5 2.3 1.4 2.0 1.8 -0.0 -0.8
Ulcerative Colitis 0.4 0.5 1.7 -0.8 -0.5 -0.6 -0.7 -0.2 0.7 -1.3
Blood Eosinophil Count 0.1 0.9 2.6 -0.3 0.5 -1.3 -0.8 -1.0 -1.6 0.4
Blood Platelet Count 0.3 3.5 8.2 -0.9 -2.2 -1.0 -1.8 -2.9 -2.0 -1.6
Blood Red Count 0.1 0.5 1.6 0.5 -0.4 -0.1 -0.6 -1.3 0.4 1.1
Blood White Count 0.2 1.2 2.8 -0.9 1.6 -0.3 -0.8 -1.0 -1.7 -0.7
Heel T-Score 0.2 1.6 6.3 -1.2 -0.0 1.6 -0.6 -0.2 -0.4 2.5
BMI 0.1 0.7 2.3 0.4 1.5 -0.2 0.2 -0.1 -1.1 -1.1
Height 0.1 2.8 7.2 1.0 -2.3 2.7 -0.7 -0.2 2.2 0.7
Waist Hip Ratio (WHR) 0.2 0.8 2.8 0.4 0.2 -1.4 0.4 -0.0 0.3 -1.7
Systolic Blood Pressure 2.7 13.7 24.7 5.0 4.3 0.9 4.8 4.5 1.8 2.2
Smoking Status 0.3 0.7 2.0 0.1 -0.2 -1.4 0.1 -0.1 -1.1 -1.4
Allergy or Eczema 0.2 0.5 1.8 -0.2 -0.4 0.2 -1.0 -0.5 -0.0 -1.4
Cardiovascular Disease 1.7 5.8 11.6 3.4 3.0 0.6 3.2 2.8 -0.8 -0.8
Hypothyroidism (self reported) 0.3 0.8 3.6 -0.6 -0.9 0.4 0.0 0.4 -1.9 -0.6
Respiratory disease 0.4 0.9 3.7 0.1 1.1 -1.1 0.2 -0.2 -0.4 -1.9
Type 2 Diabetes (T2D) (2018) 12.8 24.0 53.7 7.3 4.8 -0.1 7.0 6.3 -1.5 0.4
Lung FEV1/FVC ratio 23.3 118.0 237.2 -12.7 -13.7 -3.7 -14.4 -15.4 -2.7 -3.5
Lung FVC 4.8 24.3 45.4 -6.7 -5.6 -1.9 -6.7 -6.5 1.3 0.2
Neuroticism 0.7 1.8 4.6 1.2 1.6 -0.4 1.5 1.1 0.4 -2.1
Chronotype (morning person) 2.3 5.3 8.5 2.7 2.1 0.5 2.9 2.7 -2.2 -2.1
Hair Pigment 0.0 1.1 3.2 1.0 1.2 0.1 1.3 0.7 -0.3 -1.8
Tanning 0.0 0.3 0.7 -0.9 -0.5 -0.4 -0.8 -0.1 0.4 -0.7
Hand grip strength (left) 0.1 0.4 2.2 0.1 0.5 -0.4 0.2 0.3 0.2 -1.5
Number of treatments/medications taken 1.8 3.3 4.5 1.9 1.9 -2.1 2.0 1.9 -0.9 -1.8
Average weekly spirits intake 1.2 1.5 2.6 -1.6 -1.3 -0.7 -1.5 -1.4 -0.0 -1.2
Sensitivity / hurt feelings 1.2 2.0 7.9 0.4 1.8 -0.6 0.5 0.1 -1.4 -2.8
Frequency of depressed mood in last 2 weeks 0.5 0.6 2.0 0.4 1.0 -1.4 0.8 0.5 0.1 -0.6
Hearing difficulty/problems: Yes 1.1 1.7 3.6 0.9 1.8 -0.6 1.4 1.9 0.5 1.2
Relative age of first facial hair 0.4 0.8 4.0 -0.6 -0.6 -2.0 -0.0 -0.5 -0.4 -0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.3 1.1 0.3 -0.5 1.0 0.7 -0.9 -0.5
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.9 1.7 0.4 0.9 1.3 0.7 0.4 -0.1
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 0.8 1.1 0.4 1.0 0.3 -0.1 -1.1
Systolic blood pressure, automated reading 5.3 15.4 27.8 5.3 4.6 0.7 5.1 4.6 2.5 2.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.6 0.8 -0.7 -0.4 0.6 0.2 0.0 0.2
Angina 2.1 2.8 5.4 1.8 2.3 0.2 2.1 2.2 -1.2 -0.5
Medication for hormone replacement therapy 1.0 1.2 3.0 -0.6 -1.1 0.6 -0.6 -0.5 1.6 1.7
Vitamin and mineral supplements 0.5 0.7 2.1 -0.2 0.7 0.8 -0.1 -0.0 -1.3 1.4
Supplements: Zinc 2.4 2.6 6.4 -1.9 -2.5 -0.0 -1.9 -2.0 0.7 -0.5
Medication: Co-codamol 0.8 1.0 2.1 0.8 1.2 0.6 0.8 1.3 0.3 -1.4
Medication: Metformin 11.1 15.7 33.1 5.8 4.2 -0.7 5.4 5.1 -1.5 -1.0
Diabetes (father) 1.3 1.6 5.1 2.2 0.6 -0.9 1.8 1.2 0.0 -0.5
Diabetes (mother) 15.3 19.5 37.1 6.1 5.5 -0.3 5.9 5.7 -1.2 0.3
Severe depression (siblings) 0.7 0.7 2.8 0.6 0.5 0.6 0.2 0.1 -1.7 -1.2
Pack years adult smoking proportion 0.8 1.2 4.5 0.1 0.7 -0.4 0.2 -0.3 -1.8 -2.1
Impedance of leg (right) 0.3 1.5 2.7 0.1 -1.5 0.7 -0.8 -1.4 1.6 -1.6
Leg fat-free mass (left) 0.2 1.2 1.9 1.3 1.1 0.8 0.9 1.3 0.1 1.4
Trunk fat percentage 0.2 0.8 2.0 1.2 1.0 -0.2 0.3 0.1 1.4 -1.0
Hand grip strength (right) 0.2 0.5 1.4 0.4 0.5 -0.3 0.3 0.6 1.2 -1.1
Townsend deprivation index at recruitment 0.3 0.4 1.2 0.0 -0.2 -1.1 -0.3 -0.2 1.1 0.7
Current tobacco smoking 0.4 0.6 1.8 0.5 0.2 -0.5 0.6 0.6 -1.2 -1.4
Average weekly fortified wine intake 0.6 0.8 2.7 -0.5 0.1 0.8 -0.7 -0.4 1.6 1.0
Maternal smoking around birth 0.3 0.4 0.7 -0.8 -0.3 0.6 -0.6 -0.4 0.4 -0.9
Fed-up feelings 1.2 2.2 4.5 1.7 1.1 -1.4 2.1 1.6 0.0 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.7 -1.0 -0.7 -1.9 -0.4 -0.9 0.3 -0.1
Relative age voice broke 0.5 0.8 4.5 -0.6 -0.2 -2.1 -0.3 -0.8 0.1 0.4
Taking other prescription medications 0.8 1.2 3.1 -0.0 -0.1 -1.6 0.0 -0.2 -1.6 -1.8
Age when periods started (menarche) 0.5 1.2 2.6 1.1 0.6 -1.3 1.6 0.9 -1.2 -0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 0.9 0.7 -0.2 0.7 1.0 0.7 0.8 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.3 0.6 1.5 -0.4 1.6 1.8 0.5 0.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.0 1.4 0.9 0.8 0.8 1.1 0.7 0.2
Qualifications: CSEs or equivalent 0.7 1.0 1.9 1.1 1.4 0.4 1.4 1.2 0.3 -0.3
Serious illness, injury or assault to yourself 0.9 1.1 3.2 1.8 0.3 -0.3 1.2 0.8 -1.2 -0.8
High blood pressure 2.6 7.4 13.2 3.6 3.6 0.7 3.6 3.2 -0.9 0.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.6 -0.1 -0.4 0.3 -0.7 -0.4 -0.8 -1.6
Multivitamins +/- minerals 0.7 0.9 2.1 -0.5 -1.1 0.4 -0.6 -0.7 1.3 -1.4
Stomach or abdominal pain in last month 0.5 0.6 2.2 0.2 -0.6 0.1 0.0 0.0 -1.5 -1.2
Supplements: Glucosamine 0.1 0.1 0.6 -0.4 0.2 -0.4 -0.0 0.1 -0.2 -0.7
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.6 -1.5 -1.6 0.9 -1.6 -1.4 0.2 -0.4
Medication: Atenolol 1.8 2.2 4.5 1.3 1.3 0.3 1.4 2.1 1.9 1.3
Medication: Levothyroxine sodium 0.6 1.0 3.2 0.4 0.4 0.2 1.3 1.1 -1.8 -0.4
Sitting height 0.2 1.5 4.9 -0.0 -1.0 1.9 -0.7 -0.2 0.8 2.2
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 -0.4 0.2 -0.9 -0.4 -0.2 0.9 0.6
High blood pressure (mother) 1.5 2.0 4.1 2.0 1.9 1.0 1.6 1.4 -0.4 0.8
Body mass index (BMI) 0.5 2.2 7.3 1.5 2.7 -0.5 1.5 1.4 -0.5 -0.9
Impedance of leg (left) 0.4 1.8 3.7 -0.3 -1.9 0.5 -1.2 -1.7 1.4 -1.5
Leg predicted mass (left) 0.2 1.1 1.7 1.3 1.0 1.0 0.9 1.3 0.1 1.3
Trunk fat mass 0.2 0.9 2.3 1.5 1.2 0.1 0.7 0.6 1.2 -0.7
Waist circumference 0.5 1.8 4.7 1.7 2.2 -0.2 1.3 1.1 -0.1 -1.4
Number of incorrect matches in round 1.1 1.8 4.7 -1.0 -0.2 -0.3 -1.2 -1.2 -2.0 -2.2
Past tobacco smoking 0.3 0.5 1.3 -0.3 -0.4 1.1 -0.0 0.4 1.1 0.6
Alcohol usually taken with meals 1.1 1.8 4.0 -1.2 -2.0 0.0 -1.3 -0.9 -1.4 1.6
Nervous feelings 0.4 0.8 3.1 1.1 0.3 -0.6 0.9 0.0 1.8 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.6 0.4 0.0 -1.1 0.8 0.1 -0.5 -1.6
Hearing difficulty/problems with background noise 1.6 2.6 5.8 1.1 1.6 -1.3 1.5 2.1 0.3 2.4
Hair/balding pattern: Pattern 2 0.9 1.1 3.7 -0.7 -1.2 0.6 -1.0 -0.7 0.4 1.9
Had menopause 0.6 0.8 1.6 1.1 1.0 1.3 1.2 0.4 0.1 0.2
Had other major operations 0.1 0.2 0.6 0.1 0.4 -0.7 -0.0 -0.1 0.5 0.5
Forced vital capacity (FVC) 3.5 13.4 24.9 -4.8 -4.7 -1.1 -5.0 -4.8 -0.1 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.5 1.1 1.7 0.6 1.8 2.1 0.6 1.1
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 3.1 -0.1 0.6 -1.8 0.5 0.2 0.6 -1.5
Qualifications: None of the above 1.3 2.9 14.3 -0.5 0.5 0.1 -0.2 -0.5 -2.3 -3.8
Financial difficulties in last 2 years 1.0 1.3 2.5 -1.6 -0.5 0.5 -1.5 -1.3 -1.0 -1.0
Mouth/teeth dental problems 1.2 1.8 3.3 -1.8 -1.4 0.2 -1.8 -1.8 -0.9 -0.2
Heart attack 1.9 2.4 4.2 1.8 2.0 0.8 1.9 2.0 1.2 0.0
Allergy 0.1 0.3 1.5 -0.0 -0.3 0.2 0.3 0.7 0.0 1.2
Pain all over the body in last month 1.3 1.4 5.3 0.7 1.1 0.6 0.5 0.8 -2.3 -1.4
Diabetes (self-reported) 6.9 10.6 24.2 4.9 3.1 -0.7 4.6 4.1 -1.3 -0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.2 -0.4 -0.8 -0.8 -0.2 -0.7 0.0
Medication: Ramipril 3.6 4.7 9.2 2.8 2.4 -1.3 2.9 3.0 0.3 0.1
Medication: Simvastatin 4.1 6.0 11.7 3.2 3.4 -0.9 3.2 2.9 0.6 -0.6
Fluid intelligence score 0.5 1.1 5.4 0.0 -0.6 -0.2 0.1 0.5 1.3 2.3
Illnesses of siblings 1.9 2.7 6.5 -1.8 -2.5 -0.3 -1.9 -1.5 -0.1 1.8
Neuroticism score 0.4 0.8 2.0 0.9 1.0 -0.2 1.0 0.7 0.7 -1.4
Weight 0.2 1.2 2.6 1.6 1.6 0.5 1.1 1.3 0.3 -0.0
Impedance of arm (right) 0.6 2.9 7.0 -0.9 -2.6 -1.0 -2.0 -1.9 2.0 0.1
Arm fat percentage (right) 0.3 1.0 3.1 1.2 1.8 -0.8 0.6 0.5 0.7 -0.9
Trunk fat-free mass 0.3 2.0 3.6 1.7 1.2 1.6 1.6 1.9 -0.0 0.8
Hip circumference 0.2 0.7 1.6 1.2 1.3 0.4 0.7 0.9 0.0 -0.1
Time employed in main current job 2.3 2.7 9.2 0.1 -0.4 -2.2 0.3 0.8 3.0 2.0
Alcohol intake versus 10 years previously 2.1 3.1 8.4 2.1 2.9 0.3 1.8 1.8 1.1 -1.0
Father’s age at death 0.2 0.3 1.0 1.0 -0.0 -0.3 0.8 0.0 -0.7 -0.2
Worrier / anxious feelings 0.1 0.2 1.3 0.0 -0.3 0.2 0.1 -0.0 1.1 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.1 0.6 0.7 -0.1 0.8 0.3 -1.4 -1.5
Falls in the last year 0.5 0.7 3.3 0.2 -0.9 -0.3 -0.2 -0.6 -0.4 -1.8
Hair/balding pattern: Pattern 3 0.3 0.4 1.2 -0.6 -0.4 -1.1 -0.6 -0.7 0.4 -0.3
Number of live births 0.6 0.9 2.3 -0.0 0.6 -0.9 -0.2 -0.5 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1) 11.4 38.5 71.2 -7.8 -8.0 -1.8 -8.3 -8.4 -0.8 -0.7
Pulse rate 3.4 5.7 10.1 -2.8 -2.6 -0.2 -3.2 -3.0 1.2 2.0
Happiness 0.1 0.2 0.4 -0.2 -0.5 0.4 -0.2 -0.5 0.6 0.3
Noisy workplace 0.4 0.5 1.6 0.1 1.1 -1.3 0.1 -0.1 -0.6 0.3
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.7 -0.4 0.1 2.2 -0.5 0.0 -1.3 2.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.8 0.2 -0.9 -0.5 0.2 0.0 1.3 -0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 2.1 0.3 0.8 -1.4 0.9 1.0 1.2 -1.0
Asthma 0.2 0.5 1.5 -0.3 0.6 -1.2 0.0 -0.4 0.1 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 -0.1 -0.8 -0.6 -0.7 0.3 -0.4 -0.1
Medication: Cholesterol lowering 3.7 5.8 10.8 3.0 3.3 0.6 3.2 3.1 0.2 -0.7
Depression (self-reported) 0.7 0.8 1.6 0.6 0.4 -1.1 0.9 0.7 -1.0 -1.3
Medication: Lansoprazole 1.1 1.3 3.5 0.5 0.0 -0.6 -0.5 -1.2 -1.8 -1.9
Prospective memory result 0.2 0.2 0.9 0.1 -0.9 -0.2 -0.2 -0.2 0.5 0.5
Lung cancer (father) 0.8 0.9 2.2 -1.3 -1.5 0.0 -0.8 -0.9 -0.9 -0.1
Illnesses of mother 1.9 2.4 6.0 -1.5 -2.5 0.2 -1.8 -1.7 -1.0 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 10.9 34.8 65.5 -7.5 -7.5 -0.8 -8.0 -8.1 -0.6 -0.4
Pulse wave Arterial Stiffness index 0.1 0.2 0.5 0.2 0.2 0.6 -0.2 -0.2 -0.3 -0.7
Impedance of arm (left) 1.0 4.4 9.5 -1.3 -3.1 -1.1 -2.4 -2.3 2.6 0.6
Arm fat mass (right) 0.3 1.1 3.0 1.4 1.7 -0.2 1.0 0.9 0.3 -0.7
Trunk predicted mass 0.4 2.1 3.8 1.8 1.3 1.7 1.6 2.0 -0.0 0.8
Standing height 0.2 2.3 5.4 0.5 -2.2 2.3 -0.6 -0.0 1.6 1.6
Length of working week for main job 1.1 1.2 2.9 -1.0 -0.9 1.1 -1.6 -1.7 0.3 -0.2
Exposure to tobacco smoke at home 0.6 0.6 2.8 0.2 1.7 -0.2 0.8 0.6 -0.6 -0.3
Breastfed as a baby 0.7 0.9 2.4 0.5 1.0 0.3 0.7 0.7 -1.2 -1.5
Tense / ‘highly strung’ 0.3 0.5 2.7 0.3 0.4 -0.3 0.0 -0.3 0.7 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.9 0.2 -0.2 -0.9 0.6 0.5 0.3 -1.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 -0.7 -0.5 0.0 -0.3 -0.7 -0.1 -0.6
Birth weight of first child 0.5 1.0 2.9 1.4 -0.4 -0.2 0.9 1.0 0.4 1.7
Peak expiratory flow (PEF) 8.5 19.7 39.2 -5.4 -5.5 -1.1 -6.1 -6.3 -0.7 -1.0
Pulse wave reflection index 1.1 1.3 4.0 0.3 1.0 0.6 0.6 0.8 -1.6 -2.0
Ever highly irritable/argumentative for 2 days 1.3 1.6 2.6 0.9 1.6 -1.3 1.1 1.2 -0.9 -1.5
Loud music exposure frequency 0.9 1.0 2.2 -1.1 -0.9 -0.3 -1.0 -1.5 0.4 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.8 -0.7 -0.6 1.3 -0.5 -0.1 -0.3 -0.4
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.3 1.8 1.4 -0.5 1.5 1.2 0.8 1.0
Blood clot in the leg (DVT) 0.4 0.5 1.7 0.6 0.6 -1.3 0.2 0.0 -0.8 -0.5
Medication: Paracetamol 0.9 1.5 3.6 1.2 0.7 -1.2 0.9 0.7 -1.5 -1.9
Headache pain in last month 0.7 1.3 2.4 -1.6 -1.0 -0.2 -1.4 -1.1 0.1 -1.5
Medication for cholesterol, blood pressure or diabetes 6.7 11.2 20.0 -4.3 -4.4 -1.2 -4.3 -4.5 -0.5 -0.3
Glaucoma (self-reported) 0.5 0.6 1.9 -0.5 -1.4 -0.2 -0.3 -0.3 -0.9 -0.9
Gout (self-reported) 0.4 0.5 1.8 -0.1 0.2 0.3 -0.4 -0.3 1.4 1.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.5 0.1 -0.6 0.3 0.7 0.8 -1.9 -0.4
Medication: Amlodipine 1.1 1.5 3.7 1.5 1.9 -0.2 1.1 1.5 -0.5 0.6
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.3 0.1 0.9 -0.8 0.2 -0.2 -1.1 -1.5
Birth weight 0.9 1.9 4.0 0.6 1.5 0.8 1.2 2.0 1.7 1.3
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.1 -1.8 -0.2 -0.5 -1.6 -1.7 0.2 -0.0
High blood pressure (siblings) 0.5 0.7 3.3 0.0 1.0 -0.5 0.4 -0.3 -0.5 -1.8
Forced vital capacity (FVC), Best measure 3.0 11.0 20.9 -4.4 -4.2 -0.3 -4.6 -4.3 0.2 0.6
Body fat percentage 0.3 1.3 2.9 1.5 1.7 -0.2 0.8 0.6 1.4 -0.9
Leg fat percentage (right) 0.8 2.7 6.0 2.2 2.4 -0.3 1.7 1.3 0.9 -1.7
Arm fat-free mass (right) 0.4 2.2 4.8 1.7 1.4 2.2 1.5 1.6 0.1 1.1
Exposure to tobacco smoke outside home 0.5 0.6 2.0 0.2 0.3 -0.7 0.4 0.9 -0.9 1.4
Comparative body size at age 10 0.8 2.1 4.7 1.3 2.1 0.0 1.5 2.2 1.3 0.2
Number of full brothers 0.3 0.4 2.1 -0.2 -0.5 -0.2 -0.1 0.1 -1.5 -0.2
Worry too long after embarrassment 0.3 0.5 2.0 0.5 0.9 1.4 0.4 0.2 0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.3 -0.1 0.5 0.3 -0.1 0.8 0.4
Wheeze or whistling in the chest in last year 1.3 2.3 4.3 1.8 2.1 -0.4 1.9 2.1 -0.6 -0.2
Number of children fathered 1.0 1.1 3.3 -0.8 -1.4 0.2 -0.7 -1.0 1.8 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 3.9 1.9 1.2 1.2 2.0 1.5 -0.2 0.6
Age at first live birth 0.3 0.5 1.8 -0.7 -0.4 -0.4 -0.4 -0.5 -1.3 -0.6
Pulse wave peak to peak time 0.2 0.2 0.9 -0.1 -0.2 -0.0 0.3 0.3 0.4 1.0
Health satisfaction 0.5 0.7 1.7 0.7 1.3 -1.2 0.9 0.3 0.5 0.0
Shortness of breath walking on level ground 0.4 0.5 2.1 -0.3 -0.1 -0.7 -0.6 -0.8 -0.4 -1.4
Qualifications: College or University degree 0.9 3.0 9.1 -1.5 -1.8 0.3 -1.5 -1.4 1.4 3.0
Eye problems/disorders: None of the above 0.5 0.6 2.6 0.2 0.8 0.2 0.1 0.0 0.9 1.6
Mouth/teeth dental problems: Loose teeth 2.9 3.4 5.3 2.2 2.1 2.0 2.3 2.2 -0.7 0.5
Emphysema/chronic bronchitis 0.3 0.3 1.4 0.4 0.3 0.1 0.6 0.3 1.2 0.4
Medication for pain relief, constipation, heartburn 1.2 2.0 5.1 -0.8 -1.3 0.8 -0.7 -0.9 2.1 2.2
Neck or shoulder pain in last month 1.6 2.2 3.5 1.9 1.5 -0.7 1.9 1.1 -1.8 -1.2
Medication: Blood pressure 5.1 9.0 15.9 4.0 3.9 1.0 3.8 4.0 0.3 0.5
Angina (self-reported) 2.5 3.3 6.3 2.0 2.5 0.3 2.3 2.4 -1.2 -0.7
Migraine (self-reported) 0.5 0.6 1.1 0.8 1.0 -0.1 0.0 0.7 -1.0 -1.0
Medication: Ibuprofen 0.8 0.9 4.2 -0.4 -0.9 -2.1 -0.8 -0.1 0.7 0.3
Medication: Allopurinol 1.0 1.4 4.1 1.0 0.7 -0.1 0.5 0.4 2.0 1.8
Medication: Omeprazole 2.0 2.4 5.4 -1.7 -2.1 0.3 -2.3 -1.9 0.1 -0.5
Medication: Seretide 50 evohaler 1.4 1.6 5.5 -0.3 1.4 -0.2 0.3 -0.6 -2.3 -1.8
Mean time to correctly identify matches 0.6 1.1 4.0 -0.7 0.7 2.0 -0.0 0.7 -0.6 -1.4
Heart disease (mother) 0.6 0.7 1.4 -1.2 -0.1 0.1 -0.9 -1.1 0.7 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 6.2 1.0 0.1 -0.4 0.8 0.6 -0.8 -2.5
Whole body fat mass 0.4 1.5 3.3 1.8 1.8 0.2 1.1 1.0 1.1 -0.7
Leg fat mass (right) 0.6 2.2 5.4 2.1 2.3 0.3 1.5 1.4 0.7 -0.9
Arm predicted mass (right) 0.4 1.8 4.7 1.5 1.2 2.2 1.3 1.4 -0.2 0.8
Pulse rate, automated reading 0.4 1.2 2.5 -0.8 -1.5 -0.7 -1.6 -1.4 0.0 0.9
Alcohol intake frequency. 0.9 2.0 3.4 -1.6 -1.3 0.5 -1.7 -1.7 -0.6 -1.8
Comparative height size at age 10 0.4 2.3 6.2 0.0 -1.8 2.5 -0.9 0.2 1.5 1.8
Number of full sisters 0.7 0.8 2.1 0.7 1.5 -0.7 1.4 0.8 0.0 0.1
Suffer from ‘nerves’ 0.5 0.7 2.7 -0.5 -0.9 0.7 -0.3 -0.7 -0.6 -1.6
Overall health rating 1.8 3.9 6.1 2.5 1.8 -0.3 2.5 2.5 -1.2 -2.2
Chest pain or discomfort 0.3 0.4 1.4 0.1 1.2 0.5 0.7 0.6 -0.6 -0.4
Had major operations 0.4 0.5 1.7 0.7 0.9 -0.4 0.2 0.4 1.3 0.3
Age at last live birth 0.4 0.5 1.9 -0.5 -0.1 -1.4 -0.2 -0.2 -1.2 -0.0
Family relationship satisfaction 0.2 0.3 0.8 0.7 0.1 0.9 0.4 0.6 0.2 -0.4
Leg pain on walking 1.2 1.5 7.8 0.4 0.3 -2.8 0.6 -0.1 -0.9 -1.0
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 5.2 2.1 1.5 -1.2 1.9 2.3 0.5 0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.8 -0.5 0.1 -0.1 -0.1 -0.1 0.8 0.9
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.8 0.9 0.9 0.4 0.7 0.8 -0.8 1.7
Medication: Aspirin 2.3 3.0 6.0 2.2 2.2 0.3 2.4 2.3 -0.3 0.4
Supplements: Vitamin C 0.1 0.1 0.3 0.2 -0.6 -0.4 0.2 0.0 0.3 -0.1
Knee pain experienced in last month 0.7 1.0 5.7 -0.4 0.5 -0.8 -0.2 -0.1 -0.7 -2.4
Hypertension (Self-reported) 2.7 7.6 14.0 3.5 3.7 1.0 3.7 3.4 -0.8 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 5.6 -1.6 -2.1 -0.3 -2.4 -2.1 -1.5 -0.8
Illnesses of father: Heart disease 2.7 3.7 6.6 2.4 2.3 0.6 2.6 2.4 1.1 -1.0
Illnesses of siblings: Diabetes 9.6 11.8 26.8 5.2 3.5 2.6 4.4 4.1 0.3 -0.7
Smoking status: Previous 0.3 0.4 1.2 -0.2 -0.5 -1.1 -0.6 -1.0 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 3.1 -0.6 -1.2 1.8 -1.0 -0.4 0.3 0.6
Whole body fat-free mass 0.3 1.9 3.3 1.7 1.3 1.5 1.4 1.8 0.0 1.1
Leg fat-free mass (right) 0.2 0.9 2.3 1.0 0.7 0.8 0.6 1.1 -0.1 1.5
Arm fat percentage (left) 0.2 0.8 2.4 1.0 1.5 -0.7 0.5 0.4 0.9 -0.5
Average weekly red wine intake 0.2 0.3 1.1 0.5 -0.8 0.1 0.0 -0.1 -1.1 -0.2
Handedness (chirality/laterality): Left-handed 1.4 1.7 5.4 0.8 1.1 -0.0 1.0 1.1 -1.6 -2.3
Mood swings 0.5 0.8 1.9 0.6 0.6 -0.7 0.7 0.7 1.3 -1.4
Loneliness, isolation 0.3 0.5 2.7 -0.4 -0.4 -0.2 0.3 0.1 -0.2 -1.6
Long-standing illness, disability or infirmity 2.0 3.1 6.4 2.5 1.4 -0.5 2.1 1.8 -0.9 -2.0
Ever had bowel cancer screening 0.9 1.0 3.0 0.8 0.3 1.4 1.1 1.7 -0.0 -0.1
Diabetes diagnosed by doctor 7.5 12.3 28.6 5.3 3.2 -0.8 5.1 4.4 -1.3 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.8 0.8 1.7 0.6 1.4 0.7 1.5 1.3
Friendships satisfaction 0.8 1.0 2.2 0.9 0.7 1.5 0.9 1.4 -0.3 0.6
Qualifications: nursing, teaching 2.0 3.0 4.0 -1.7 -1.8 0.5 -2.0 -1.9 1.8 2.0
Commuting to job workplace: Walk 0.3 0.3 1.6 -0.3 0.2 0.2 -0.1 -0.3 -1.3 -0.5
Eye problems/disorders: Cataract 1.3 1.5 2.9 -1.4 -1.7 -0.0 -1.2 -1.0 -0.7 -1.7
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.4 2.3 1.2 1.4 1.6 1.9 0.3 0.5
Medication for cholesterol 0.1 0.1 0.8 0.0 0.0 0.9 0.0 0.1 -0.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.3 -0.3 1.5 -1.0 0.4 0.3 -1.2 -0.3
Back pain experienced in last month 0.6 0.9 3.0 0.1 -0.1 0.5 0.2 -0.2 -1.7 -1.7
Mineral and other dietary supplements 0.8 1.0 4.6 1.0 1.0 0.5 0.3 0.6 -2.1 -0.2
Breast cancer (self-reported) 1.3 1.6 3.8 1.1 1.4 -2.0 1.1 1.1 -0.6 1.1
Asthma (self-reported) 0.3 0.6 1.8 -0.0 0.9 -1.3 0.2 -0.2 0.1 -1.3
Osteoporosis (self-reported) 0.1 0.1 0.3 0.3 -0.5 -0.5 0.1 0.0 -0.2 0.0
Osteoarthritis (self-reported) 0.6 0.7 2.7 -0.1 -0.1 -1.3 -0.5 -0.8 0.0 -1.7
Medication: Aspirin 2.6 3.4 7.0 2.4 2.2 0.4 2.6 2.5 -0.1 0.4
Medication: Gliclazide 3.2 3.7 9.0 3.0 1.7 -1.3 2.8 2.1 0.5 -0.0
Illnesses of father: None of the above (group 1) 4.4 5.5 12.7 -3.6 -2.3 0.9 -3.1 -2.5 -1.6 0.8
Smoking status: Current 0.4 0.7 2.0 0.3 0.3 -0.6 0.5 0.5 -1.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.9 18.9 36.7 -5.6 -5.3 -2.0 -5.6 -6.1 -0.0 -0.0
Whole body water mass 0.3 1.8 3.0 1.6 1.2 1.6 1.4 1.7 -0.1 1.1
Leg predicted mass (right) 0.2 0.8 2.4 0.9 0.7 0.8 0.6 1.1 -0.1 1.5
Arm fat mass (left) 0.2 1.0 3.0 1.4 1.7 0.0 0.9 0.9 0.5 -0.6
Number of self-reported non-cancer illnesses 1.8 3.2 4.9 1.8 1.9 -0.3 1.8 1.6 -2.2 -2.2
Average weekly champagne plus white wine intake 1.1 1.5 3.2 -1.3 -1.8 -1.0 -1.7 -0.9 -0.1 0.8
Miserableness 0.6 1.0 6.3 -0.5 0.4 -0.3 0.2 0.1 -0.5 -2.5
Guilty feelings 0.7 1.0 2.4 -0.9 -0.6 0.7 -1.2 -1.2 -0.2 1.5
Wears glasses or contact lenses 1.9 2.2 6.3 1.2 0.5 -0.8 1.5 1.8 2.5 -1.2
Ever taken oral contraceptive pill 0.6 0.7 1.9 -1.1 0.5 -0.8 -0.2 -0.4 -0.8 -1.4
Hearing aid user 0.5 0.6 1.0 0.5 0.9 -1.0 0.6 0.7 0.9 0.5
Mother’s age at death 0.8 1.0 2.3 1.3 1.0 0.8 1.0 1.5 -0.1 0.0
Financial situation satisfaction 0.3 0.3 1.3 -0.8 -0.1 0.5 -0.1 -0.2 -0.3 1.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 -0.1 -0.2 -0.4 -0.1 0.4 0.4 -0.6
Commuting to job workplace: Public transport 0.6 0.8 2.5 0.7 0.2 0.7 0.8 0.8 -1.6 -0.7
Eye problems/disorders: Glaucoma 0.3 0.4 1.3 -0.1 -0.7 -0.2 0.1 0.1 -0.9 -1.1
Medication: Blood pressure 0.3 0.6 1.0 0.7 0.9 -0.6 1.0 0.7 -0.9 0.2
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.8 0.2 1.2 1.3 0.5 0.7 0.2 -0.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 4.8 0.1 -0.3 -0.1 0.8 0.4 2.2 -0.9
High cholesterol (Self-reported) 2.2 3.9 7.6 2.3 2.8 -0.3 2.6 2.6 0.9 0.2
Medication: Bendroflumethiazide 1.0 1.6 3.5 1.4 1.6 -0.5 1.9 1.6 -0.6 0.2
Medication: Paracetamol 1.2 1.9 3.7 1.6 1.4 -1.2 1.5 1.0 -0.7 -1.9
Medication: Lisinopril 1.4 1.9 7.7 1.1 2.8 -0.1 1.3 1.3 0.8 0.3
Medication: Atorvastatin 1.5 1.8 4.3 1.4 1.9 0.1 1.5 2.1 -0.1 -0.5
Illnesses of father: High blood pressure 2.4 2.9 7.3 2.7 1.8 0.8 2.2 1.6 0.0 -1.4
Alcohol drinker status: Never 1.0 1.3 3.7 0.5 -0.4 1.9 0.7 0.9 0.3 -1.8
Ever smoked 0.4 0.7 2.9 0.7 0.7 -0.9 0.6 0.1 -1.7 -0.5
Basal metabolic rate 0.3 1.5 2.6 1.6 1.3 1.2 1.3 1.6 0.1 0.8
Leg fat percentage (left) 0.6 2.1 4.6 1.9 2.1 -0.6 1.4 1.0 0.6 -1.7
Arm fat-free mass (left) 0.4 1.9 2.9 1.7 1.5 1.6 1.5 1.7 -0.3 0.5
Number of operations (self-reported) 0.8 1.2 2.2 1.4 1.3 -1.5 1.1 0.7 0.8 0.4
Average weekly beer plus cider intake 1.6 2.3 4.2 1.5 1.5 2.1 1.5 1.4 1.5 -0.9
Irritability 1.5 2.5 7.2 1.2 0.6 -2.7 1.1 1.5 2.1 0.6
Risk taking 1.0 1.5 5.0 -1.2 -2.2 0.2 -1.4 -1.1 -0.7 -0.6
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.4 1.2 0.8 -0.1 1.0 0.8 0.2 -0.2
Fractured/broken bones in last 5 years 0.6 0.8 2.7 -0.4 -1.7 -1.0 -0.6 -0.6 0.9 0.4
Age started oral contraceptive pill 0.1 0.1 0.4 0.3 -0.1 -0.5 0.2 -0.2 0.6 0.3
Diastolic blood pressure, automated reading 0.7 2.1 4.4 1.5 1.7 0.1 1.4 1.4 1.3 2.1
Ever depressed for a whole week 0.5 0.6 2.3 0.9 0.5 -1.5 0.8 0.6 -0.2 -0.0
Unable to work because of sickness or disability 0.4 0.6 2.2 0.2 0.3 -0.2 0.5 0.5 -1.0 -1.5
Commuting to job workplace: Cycle 1.6 1.9 5.1 1.8 0.9 -0.2 1.8 2.3 -0.3 1.1
Myopia 0.2 0.2 0.7 -0.3 -0.0 0.8 0.4 0.6 -0.3 -0.4
Vascular/heart problems diagnosed by doctor 2.3 6.2 11.1 -3.3 -3.3 -1.0 -3.3 -3.0 0.8 -0.3
Cholesterol lowering medication 1.9 2.8 5.7 1.8 2.4 -1.0 2.2 2.0 -0.7 -0.2
Medication: Omeprazole (e.g. Zanprol) 2.5 3.0 7.2 -2.1 -1.8 0.1 -2.7 -2.3 -0.6 -0.6
Pain experienced in last month 1.2 2.0 6.4 -0.2 -0.9 -0.5 -0.7 -0.6 2.5 2.5
Supplements: Calcium 1.2 1.3 2.6 -1.1 -1.0 -1.6 -1.2 -1.5 0.2 0.6
Basal cell carcinoma (self-reported) 0.8 0.9 1.8 -1.1 -0.5 0.6 -1.3 -1.2 -1.1 0.5
Heart attack/myocardial infarction (self-reported) 1.6 2.1 3.8 1.6 1.9 0.6 1.8 1.9 1.0 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.5 0.7 0.7 -1.6 0.4 0.2 -0.7 -0.1
Heart disease (siblings) 0.6 0.7 2.4 0.0 1.5 1.6 0.2 0.5 0.3 0.2
Alcohol drinker status: Previous 2.0 2.3 5.1 -2.1 -2.2 -0.1 -1.5 -1.8 -0.8 0.1
Pack years of smoking 0.7 1.1 5.0 -0.1 0.7 -0.5 0.0 -0.4 -1.3 -2.2
Impedance of whole body 0.6 3.1 7.0 -0.9 -2.6 -0.2 -2.0 -2.3 2.1 -0.4
Leg fat mass (left) 0.5 1.8 4.4 1.9 2.1 0.1 1.4 1.3 0.6 -0.8
Arm predicted mass (left) 0.4 2.0 4.1 1.6 1.6 2.0 1.4 1.6 -0.3 0.4