TWAS hub - SEC61A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1260	0.0310	2.5e-07	0.086	0.063	0.077	0.078	0.079	1.2e-10	3.6e-08	1.1e-09	9.9e-10	7.9e-10
2	GTEx	Artery Aorta	0.2580	0.0610	2.6e-05	0.169	NA	0.152	NA	0.169	1.3e-09	NA	1.0e-08	NA	1.2e-09
3	GTEx	Artery Tibial	0.1425	0.0429	1.9e-04	0.054	NA	0.046	NA	0.047	4.7e-05	NA	1.6e-04	NA	1.3e-04
4	GTEx	Brain Cerebellar Hemisphere	0.3070	0.0880	8.9e-04	0.259	NA	0.154	NA	0.238	2.5e-07	NA	9.1e-05	NA	8.4e-07
5	GTEx	Brain Cerebellum	0.3860	0.0860	3.5e-05	0.344	NA	0.200	NA	0.304	5.7e-11	NA	1.4e-06	NA	1.1e-09
6	GTEx	Esophagus Gastroesophageal Junction	0.2840	0.0960	2.0e-03	0.126	NA	0.101	NA	0.088	2.7e-05	NA	1.7e-04	NA	4.5e-04
7	GTEx	Esophagus Muscularis	0.1770	0.0570	7.7e-04	0.089	NA	0.078	NA	0.154	4.6e-06	NA	1.8e-05	NA	1.2e-09
8	GTEx	Nerve Tibial	0.2093	0.0500	5.5e-06	0.097	NA	0.146	NA	0.092	2.2e-07	NA	1.6e-10	NA	4.8e-07
9	METSIM	Adipose	0.0699	0.0234	3.5e-04	0.023	0.020	0.020	0.020	0.018	1.8e-04	4.7e-04	4.4e-04	4.4e-04	7.3e-04
10	NTR	Blood	0.0332	0.0116	1.2e-03	0.000	0.008	0.004	0.010	0.003	3.6e-01	7.6e-04	1.7e-02	1.8e-04	3.1e-02
11	YFS	Blood	0.1632	0.0209	0.0e+00	0.148	0.185	0.211	0.208	0.212	6.2e-46	2.6e-58	3.2e-67	6.0e-66	1.3e-67
12	TCGA	Brain Lower Grade Glioma	0.0312	0.0198	2.5e-03	0.023	0.026	0.019	NA	0.019	1.0e-03	5.2e-04	2.8e-03	NA	2.7e-03
13	TCGA	Testicular Germ Cell Tumors	0.1030	0.0510	2.4e-03	0.032	0.068	0.070	NA	0.030	2.7e-02	2.1e-03	1.8e-03	NA	3.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Type 2 Diabetes (T2D) (2018)	8.9	16.7	26.5	-3.7	-4.9	-4.8	-4.8	-5.0	-5.2	-4.6	-4.0	-3.5	0.1	-1.3	-3.6	4.2
Eye problems/disorders: Diabetes related eye disease	7.6	8.4	11.1	-3.0	-3.0	-3.3	-3.0	-3.1	-2.8	-3.1	-2.9	-2.5	-2.9	-3.0	-2.3	2.5
HbA1C	7.1	7.9	13.5	-1.6	-3.2	-3.1	-3.3	-2.9	-3.6	-2.8	-3.7	-2.7	-0.6	-3.0	-2.8	1.5
Diabetes (self-reported)	6.3	9.7	14.8	-2.7	-3.6	-3.6	-3.8	-3.9	-3.7	-3.5	-3.1	-2.6	-0.5	-1.4	-2.9	3.3
Peak expiratory flow (PEF)	5.9	13.7	27.9	4.5	3.7	4.3	3.6	3.3	3.2	4.1	4.0	5.3	-2.7	1.4	4.8	-0.0
Medication: Metformin	5.7	8.1	11.8	-2.9	-3.2	-3.3	-3.4	-3.3	-3.4	-3.3	-2.9	-2.8	0.5	-0.7	-3.1	1.9
Diabetes (mother)	5.6	7.1	15.9	-2.5	-3.0	-2.8	-3.2	-3.0	-2.8	-2.9	-2.4	-4.0	1.3	-0.2	-2.8	1.6
Diabetes diagnosed by doctor	5.5	9.0	13.4	-2.8	-3.5	-3.6	-3.6	-3.7	-3.4	-3.4	-2.9	-2.5	-0.1	-1.2	-2.8	3.1
Lung FEV1/FVC ratio	5.3	26.7	106.1	6.3	3.4	4.9	4.0	3.2	3.6	4.9	5.4	4.5	-10.3	-1.8	6.5	2.9
Prostate Cancer	4.9	6.9	10.4	-1.5	-3.1	-2.3	-3.0	-3.0	-3.2	-2.4	-3.2	-2.4	-2.5	-2.7	-2.3	2.2
Forced expiratory volume in 1-second (FEV1)	4.8	16.2	28.2	4.6	4.0	4.2	4.2	3.9	3.5	4.4	4.1	5.2	-4.0	0.8	5.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.4	23.5	4.4	3.5	3.8	3.8	3.4	3.3	4.1	3.6	4.6	-4.2	0.6	4.8	0.8
Noisy workplace	4.1	5.1	15.5	-1.1	-2.7	-2.8	-2.2	-2.6	-3.0	-2.0	-1.8	-0.8	-0.9	-1.5	-1.6	3.9
Neck or shoulder pain in last month	3.8	5.4	9.2	-1.5	-3.0	-2.6	-2.8	-2.8	-2.6	-2.4	-2.2	-1.5	-2.1	-1.6	-1.6	2.8
Average weekly beer plus cider intake	3.7	5.4	9.7	2.8	2.0	2.7	2.0	2.2	1.4	2.5	2.1	2.1	3.1	3.1	1.8	-1.6
Forced vital capacity (FVC)	3.3	12.6	21.9	3.9	3.9	3.7	4.0	3.8	3.3	4.0	3.6	4.7	-1.3	2.1	4.7	0.0
Health satisfaction	3.2	4.2	7.4	-2.7	-1.8	-2.5	-2.2	-1.7	-2.0	-2.3	-1.9	-2.3	-0.4	-2.0	-2.7	-0.0
Mean time to correctly identify matches	3.1	5.9	9.0	2.0	2.7	2.5	2.5	2.7	3.0	2.5	2.2	2.0	2.3	2.5	2.1	-2.3
Handedness (chirality/laterality): Left-handed	3.1	3.7	6.5	1.6	1.9	1.8	2.0	1.9	2.1	1.9	1.7	1.4	2.5	2.4	1.8	-1.5
Rheumatoid Arthritis	3.0	4.1	6.4	1.9	2.5	2.3	1.9	2.3	2.4	2.1	2.3	1.7	0.9	1.8	2.1	-1.7
Fasting Glucose	2.7	3.2	6.3	-1.1	-2.1	-1.8	-2.5	-1.8	-2.4	-1.7	-2.1	-1.9	0.8	-0.7	-2.1	0.9
Loud music exposure frequency	2.7	3.0	5.3	-1.6	-1.9	-1.9	-1.7	-1.7	-1.6	-1.8	-2.3	0.4	-1.5	-2.3	-1.8	0.9
Headache pain in last month	2.7	4.7	7.4	2.6	2.2	2.3	2.0	2.2	2.5	2.5	1.6	2.4	1.6	1.9	2.7	-0.9
Pain type(s) experienced in last month: Hip pain	2.7	3.4	6.2	2.0	1.7	1.8	1.8	2.0	1.6	2.1	1.9	0.9	1.9	2.5	1.8	-1.5
Supplements: Calcium	2.7	3.0	6.6	-2.0	-1.3	-1.4	-1.7	-1.4	-1.2	-1.8	-1.8	-1.8	-2.1	-2.6	-2.0	-0.4
Coronary Artery Disease (CAD)	2.6	3.1	7.5	-1.0	-2.3	-1.7	-1.9	-2.2	-2.7	-1.8	-0.9	-1.8	-1.1	-0.9	-1.3	1.9
Type 2 Diabetes (T2D) (2012)	2.6	3.0	4.6	-1.3	-2.0	-2.0	-1.8	-2.0	-1.9	-1.9	-1.0	-2.1	-0.3	-0.1	-2.0	2.1
Lung FVC	2.6	13.1	21.6	3.5	4.0	3.7	3.6	3.6	4.1	3.8	3.4	4.6	-4.1	0.7	4.3	-1.4
Forced vital capacity (FVC), Best measure	2.6	9.6	18.0	3.5	3.3	3.2	3.5	3.3	2.8	3.6	3.1	3.8	-1.3	1.9	4.2	0.3
Bipolar Disorder or Schizophrenia	2.5	6.0	10.3	3.2	2.3	3.1	2.4	2.5	2.5	2.9	2.0	2.6	0.9	1.8	3.2	-0.9
Pain all over the body in last month	2.5	2.6	5.1	1.6	1.7	1.5	1.5	1.7	1.1	1.7	1.6	1.8	1.8	2.3	1.8	-0.5
Exposure to tobacco smoke outside home	2.4	3.2	6.8	2.6	1.2	1.6	1.8	1.4	1.0	2.0	2.2	1.6	1.5	2.4	2.3	0.7
Serious illness, injury or assault to yourself	2.3	2.8	4.1	-1.6	-1.9	-1.6	-2.0	-1.8	-1.8	-1.9	-1.9	-2.0	-0.4	-1.2	-1.6	1.1
Number of children fathered	2.3	2.6	5.7	-1.1	-1.6	-1.7	-1.4	-1.7	-1.6	-1.4	-0.8	-0.8	-2.4	-1.8	-1.3	2.4
Had major operations	2.3	2.7	4.5	-2.1	-1.7	-2.1	-1.7	-1.7	-1.9	-1.9	-1.2	-0.7	-0.8	-1.6	-1.9	1.5
Schizophrenia (2018)	2.2	4.6	8.1	2.7	2.1	2.6	2.1	2.1	2.4	2.5	1.9	2.9	0.6	1.5	2.5	-0.7
HDL Cholesterol	2.2	3.7	6.5	2.3	1.6	1.8	2.0	1.6	1.7	2.1	1.9	2.6	1.4	2.5	2.3	0.1
Risk taking	2.2	3.2	8.3	2.9	1.6	2.3	1.8	1.7	1.3	2.2	2.1	0.9	0.2	1.5	2.4	0.1
Reaction Time	2.1	4.0	6.7	1.7	2.3	2.1	2.2	2.3	2.6	2.2	1.7	2.0	1.4	1.8	1.9	-1.6
Medication: Ramipril	2.1	2.7	4.5	-2.1	-1.6	-1.6	-1.8	-1.6	-1.7	-1.9	-2.1	-0.7	1.9	-0.5	-2.1	0.4
Medication: Gliclazide	2.0	2.2	4.0	-1.1	-1.9	-1.5	-2.0	-1.9	-1.9	-1.7	-1.9	-1.1	0.6	-0.5	-1.3	1.2
Eye problems/disorders: Glaucoma	2.0	2.4	6.1	2.3	1.1	1.7	1.1	0.9	1.7	1.6	2.5	0.7	0.3	1.6	2.0	0.7
Systolic blood pressure, automated reading	1.9	5.5	9.7	-2.1	-2.7	-2.6	-3.1	-2.8	-3.1	-2.8	-2.5	-1.0	1.0	-0.8	-2.7	1.0
Happiness	1.9	2.3	3.4	-1.6	-1.6	-1.8	-1.4	-1.5	-1.8	-1.6	-1.3	-0.2	-1.6	-1.9	-1.4	1.3
Medication: Aspirin	1.9	2.5	7.8	-0.8	-1.8	-1.9	-1.7	-1.9	-2.3	-1.5	-1.1	-0.2	1.0	-0.1	-0.7	2.8
Illnesses of father: Heart disease	1.9	2.7	4.1	-1.6	-2.0	-1.8	-2.0	-2.0	-1.8	-1.8	-1.8	-1.6	0.4	-0.8	-1.8	0.7
Illnesses of siblings: Diabetes	1.9	2.3	6.0	-0.7	-1.6	-1.6	-1.5	-1.7	-2.4	-1.3	-1.7	-0.9	1.8	0.9	-0.9	1.9
Commuting to job workplace: Walk	1.9	2.1	5.5	-2.4	-1.1	-1.9	-1.1	-1.2	-0.3	-1.8	-1.0	-0.2	-1.6	-1.7	-1.9	0.2
Neuroticism (2016)	1.8	2.6	5.4	1.7	1.5	1.6	1.7	1.7	2.1	1.8	1.3	2.3	0.3	0.8	2.0	-1.1
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.9	-1.8	-1.7	-2.0	-1.6	-1.5	-0.9	-1.8	-1.8	-0.6	0.6	-1.0	-1.8	1.1
Loneliness, isolation	1.7	2.3	7.6	1.2	1.4	1.3	1.3	1.5	1.4	1.4	1.5	2.8	1.5	1.5	1.7	-0.4
Miserableness	1.7	2.9	10.0	1.7	1.6	1.6	1.8	1.6	1.4	1.7	1.5	3.2	0.7	1.6	1.7	-1.0
Schizophrenia (2014)	1.6	3.6	6.5	2.3	2.0	2.5	1.9	1.9	2.5	2.2	1.3	1.9	0.3	1.0	2.2	-1.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	3.5	1.9	1.6	1.6	1.7	1.6	1.1	1.8	1.7	1.1	-0.1	1.7	1.7	-0.1
Exposure to tobacco smoke at home	1.6	1.7	3.6	1.9	0.5	1.1	1.0	0.7	0.8	1.4	1.7	0.2	1.7	1.9	1.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.3	1.4	1.2	1.3	1.8	1.6	1.6	1.6	1.5	1.2	1.0	1.5	1.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.6	-1.4	-0.9	-1.4	-1.2	-1.1	-0.9	-1.3	-1.1	-1.5	-2.1	-2.1	-1.5	0.4
Medication: Aspirin	1.6	2.1	7.7	-0.5	-1.6	-1.7	-1.6	-1.7	-2.1	-1.3	-1.0	-0.1	1.2	0.2	-0.5	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	21.5	1.9	1.0	1.5	1.0	0.9	1.3	1.5	0.9	1.4	-4.6	-1.1	2.1	0.9
Unable to work because of sickness or disability	1.6	2.1	3.4	0.9	1.8	1.5	1.4	1.8	1.3	1.5	1.2	0.7	1.6	1.7	1.3	-1.8
Alcohol intake versus 10 years previously	1.5	2.3	10.5	1.5	1.0	1.2	1.1	1.1	0.4	1.3	1.1	1.1	3.2	2.4	1.6	-0.2
Smoking status: Previous	1.5	2.2	10.7	2.0	0.8	1.0	1.1	0.7	0.2	1.4	1.6	3.3	-0.3	1.3	1.8	1.2
Eye problems/disorders: Cataract	1.5	1.7	3.7	1.5	1.4	1.8	0.9	1.2	1.7	1.3	1.4	1.9	-0.4	0.7	0.8	-1.1
Average weekly champagne plus white wine intake	1.5	2.0	4.5	0.9	2.0	1.4	1.6	1.6	1.7	1.4	2.1	0.4	-0.0	0.7	1.5	-1.5
Ovarian Cancer	1.4	1.9	3.0	1.7	1.4	1.7	1.4	1.3	0.9	1.5	1.6	1.6	0.7	1.1	1.7	-0.2
Height	1.4	27.9	58.1	7.6	3.4	4.5	5.5	4.2	1.6	6.0	5.4	5.0	3.6	6.9	7.3	4.4
Glaucoma (self-reported)	1.4	1.6	4.3	2.1	0.8	1.6	0.8	0.7	1.2	1.4	2.0	0.9	-0.1	1.1	1.6	0.3
Number of full brothers	1.4	1.8	4.8	2.2	0.9	1.4	1.3	0.9	0.7	1.7	1.8	0.7	0.6	1.7	1.8	-0.1
Medication: Paracetamol	1.4	2.2	4.2	-1.7	-1.5	-1.9	-1.8	-1.6	-1.2	-1.7	-2.1	-1.2	0.2	-0.9	-1.5	1.0
Systolic Blood Pressure	1.3	6.6	12.5	-3.0	-2.6	-3.1	-3.0	-2.6	-3.5	-3.0	-2.6	-1.4	1.7	-1.2	-3.2	0.8
Mouth/teeth dental problems: Dentures	1.3	2.2	3.1	-1.7	-1.5	-1.7	-1.5	-1.7	-1.1	-1.8	-1.6	-1.6	-0.8	-1.4	-1.7	0.7
Medication: Lansoprazole	1.3	1.5	3.8	-1.0	-1.2	-1.0	-1.2	-1.1	-1.1	-1.1	-2.0	-1.5	-1.0	-1.5	-1.3	0.6
Comparative height size at age 10	1.3	7.4	12.7	3.5	2.7	2.8	3.0	2.8	1.4	3.1	2.0	2.9	1.6	3.4	3.6	0.5
Age at last live birth	1.3	1.9	5.4	-2.3	-0.9	-1.4	-0.9	-0.9	-0.8	-1.6	-1.3	-0.5	-1.2	-1.8	-1.9	-0.7
Breast cancer (self-reported)	1.3	1.5	3.8	-1.9	-1.0	-1.4	-1.1	-0.9	-0.8	-1.4	-0.6	-1.8	0.7	-0.8	-1.9	0.1
Commuting to job workplace: Cycle	1.3	1.6	9.6	0.7	0.9	0.4	1.1	0.9	0.7	0.9	0.9	0.2	3.1	2.0	1.2	0.7
Alzheimer’s Disease (in father)	1.2	1.3	6.6	-0.8	-1.0	-0.5	-1.4	-1.1	-0.9	-1.0	-1.2	-2.6	-0.2	-0.6	-1.1	-0.3
Triglycerides	1.2	1.9	3.4	-1.8	-1.3	-1.4	-1.5	-1.2	-1.5	-1.6	-1.2	-1.8	-0.4	-1.5	-1.7	0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.4	-0.7	-1.5	-1.4	-1.4	-1.3	-1.8	-1.2	-1.1	-0.6	-0.9	-0.8	-1.0	1.6
Supplements: Zinc	1.2	1.3	2.9	0.7	1.6	1.1	1.7	1.7	1.4	1.2	1.2	1.0	-0.8	0.2	0.7	-0.8
Diabetes (father)	1.2	1.5	2.6	-1.1	-1.6	-1.3	-1.5	-1.4	-1.5	-1.2	-1.6	-1.3	0.3	-0.8	-1.0	1.1
Pack years adult smoking proportion	1.2	1.8	4.5	-1.6	-1.1	-1.4	-1.4	-1.1	-1.0	-1.4	-1.4	-2.1	-0.6	-1.4	-1.6	-0.1
Hand grip strength (right)	1.2	3.4	6.3	2.1	1.5	1.5	1.8	1.5	0.9	1.9	2.2	2.2	2.2	2.5	2.2	0.1
Medication: Levothyroxine sodium	1.2	2.1	4.5	-1.6	-1.4	-1.8	-1.5	-1.4	-1.6	-1.7	-1.4	-0.5	-0.7	-1.4	-2.1	0.8
Mouth/teeth dental problems	1.2	1.8	3.5	1.4	1.6	1.5	1.5	1.6	1.0	1.6	1.5	1.2	-0.0	0.6	1.9	-0.7
Hair/balding pattern: Pattern 3	1.2	1.8	3.5	-1.9	-0.7	-1.5	-1.0	-0.9	-0.3	-1.5	-1.4	-1.1	-1.7	-1.8	-1.9	-0.3
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.6	0.7	1.4	1.4	1.5	1.4	1.9	1.2	1.5	0.5	-2.1	-0.7	0.7	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	5.2	1.0	0.8	0.8	0.8	0.9	0.7	1.0	1.9	0.1	2.0	2.3	1.0	-0.3
Pulse wave reflection index	1.1	1.3	3.9	-1.5	-0.9	-1.1	-0.9	-0.8	-0.6	-1.2	-0.7	-1.8	-0.7	-0.8	-2.0	-0.8
Birth weight	1.1	2.4	6.1	1.4	1.5	1.6	1.2	1.2	0.9	1.4	2.1	0.1	2.5	2.2	1.4	-1.3
Alcohol intake frequency.	1.1	2.7	4.0	1.9	1.7	1.5	1.8	2.0	1.7	1.9	1.1	1.7	1.4	1.2	2.0	-0.9
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	0.7	1.7	1.3	1.4	1.5	1.1	1.1	0.9	1.5	-0.4	-0.2	0.9	-1.5
Ever taken oral contraceptive pill	1.1	1.3	2.6	-0.9	-1.3	-1.0	-1.5	-1.5	-0.4	-1.3	-0.5	-0.1	-1.6	-1.5	-1.2	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	1.7	1.3	1.2	1.3	1.2	1.3	0.8	1.2	1.0	1.2	1.0	1.2	0.9	-1.1
Ever depressed for a whole week	1.1	1.3	2.8	-1.7	-0.9	-1.0	-0.8	-0.8	-0.8	-1.3	-1.0	-1.7	-0.8	-1.1	-1.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.9	-0.8	-1.1	-1.4	-0.7	-0.9	-1.2	-0.9	-1.6	-1.6	-0.8	-0.6	-0.6	2.2
Bipolar Disorder (2018)	1.0	1.6	3.7	1.7	1.1	1.8	1.3	1.3	1.1	1.6	0.9	0.7	0.7	1.0	1.9	-0.6
Ulcerative Colitis	1.0	1.4	2.8	0.6	1.5	0.9	1.4	1.4	1.2	1.1	1.7	-0.7	0.8	1.4	1.0	-0.8
Qualifications: CSEs or equivalent	1.0	1.4	3.0	-0.9	-1.6	-1.3	-1.5	-1.4	-1.7	-1.3	-1.4	0.0	-0.1	-1.0	-1.0	0.6
Past tobacco smoking	1.0	1.9	7.0	-2.0	-0.8	-1.0	-1.0	-0.7	-0.1	-1.4	-1.5	-2.6	-0.3	-1.6	-1.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	1.8	0.0	0.7	0.5	-0.0	-0.1	0.9	1.5	0.8	0.9	1.8	0.9	1.7
Suffer from ‘nerves’	1.0	1.5	3.2	0.5	1.2	1.0	1.5	1.5	1.6	1.1	0.9	1.4	0.5	0.7	1.5	-1.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.1	0.9	0.9	0.6	1.0	0.9	1.0	0.9	2.0	2.0	0.7	1.2	1.1	0.4
Ever smoked	1.0	1.7	4.2	1.8	0.8	1.1	1.1	1.0	0.1	1.4	1.3	2.0	0.6	1.6	1.9	0.5
Alcohol drinker status: Previous	1.0	1.2	2.0	1.1	1.3	1.1	1.4	1.4	1.1	1.3	1.2	0.2	-0.7	0.4	1.1	-1.0
Severe depression (siblings)	0.9	1.0	3.4	1.1	0.4	0.3	0.8	0.5	0.6	0.9	0.6	1.8	0.9	1.1	1.2	1.6
Stomach or abdominal pain in last month	0.9	1.1	2.5	-1.6	-0.6	-1.5	-1.0	-0.5	-1.4	-1.3	-0.6	-1.0	0.3	-1.3	-1.2	-0.3
Time employed in main current job	0.9	1.1	4.9	0.5	1.1	1.3	0.7	0.9	1.1	0.8	0.8	1.0	0.7	0.5	0.4	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.8	0.7	1.3	1.2	1.2	1.3	1.0	1.1	0.9	0.6	1.0	0.8	1.3	-1.1
Blood clot in the leg (DVT)	0.9	1.1	3.5	-0.8	-0.9	-1.2	-0.6	-0.7	-1.0	-0.8	-1.6	-1.4	-0.9	-0.6	-0.6	1.9
Irritable Bowel Disease (IBD)	0.8	1.9	3.1	1.0	1.8	1.0	1.7	1.6	1.5	1.4	1.6	1.1	1.7	1.6	0.9	-0.3
Medication for hormone replacement therapy	0.8	0.9	1.6	0.5	1.2	1.2	1.1	1.1	0.8	0.9	1.3	0.0	-1.1	0.3	0.6	-1.1
Relative age voice broke	0.8	1.2	2.6	0.5	1.5	1.0	1.3	1.6	1.5	1.1	0.8	0.3	0.3	0.5	0.9	-1.6
Nervous feelings	0.8	1.5	2.9	-1.2	-1.7	-1.5	-1.2	-1.5	-1.5	-1.4	-1.0	0.5	-0.7	-1.2	-0.4	1.3
Hair/balding pattern: Pattern 2	0.8	1.1	2.2	1.1	1.1	1.1	1.5	1.3	0.7	1.3	0.9	-0.4	0.6	0.9	1.4	-0.3
Allergy	0.8	1.9	3.3	1.0	1.4	1.4	1.5	1.5	1.6	1.3	1.2	0.6	1.7	1.2	1.1	-1.8
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.4	0.6	1.8	1.8	1.5	1.5	1.8	1.2	1.4	0.8	0.6	0.9	1.0	-1.7
Qualifications: College or University degree	0.8	2.5	6.0	-1.3	-1.4	-1.1	-1.3	-1.7	-1.1	-1.5	-1.0	-2.0	-2.4	-2.2	-1.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	6.7	-1.2	-0.5	-0.6	-0.7	-0.6	0.1	-0.8	-0.8	-2.6	-0.3	-0.7	-0.9	0.0
Osteoarthritis (self-reported)	0.8	1.0	2.7	-0.5	-0.8	-0.8	-1.0	-0.8	-1.5	-0.7	-1.2	-1.7	-1.3	-0.7	-0.9	0.7
Irritability	0.8	1.4	3.9	1.5	0.5	1.0	0.7	0.5	0.6	1.1	1.6	2.0	1.1	1.4	1.8	0.3
Basal cell carcinoma (self-reported)	0.8	0.9	2.3	1.5	0.9	0.9	0.9	0.8	0.8	1.1	0.7	1.3	0.3	0.8	1.3	0.6
Alzheimer’s Disease (including proxy)	0.7	0.9	6.5	-0.8	-0.4	-0.3	-0.8	-0.4	-0.5	-0.8	-1.0	-2.6	-1.0	-0.7	-0.8	-0.5
Waist Hip Ratio (WHR)	0.7	2.9	10.6	-1.2	-1.9	-1.6	-1.6	-1.6	-1.6	-1.6	-1.8	-3.3	-0.5	-1.2	-1.8	1.3
Cardiovascular Disease	0.7	2.3	5.0	-1.4	-1.2	-1.9	-1.4	-1.2	-1.7	-1.5	-1.3	-1.1	2.2	0.1	-1.1	2.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	-0.8	-1.1	-1.0	-0.9	-1.1	-0.8	-1.0	-0.6	-0.5	-1.1	-0.4	-0.7	1.2
Sitting height	0.7	5.1	10.3	2.9	1.6	1.9	2.4	1.9	0.7	2.5	1.8	2.6	1.0	2.9	3.2	2.4
Eye problems/disorders: None of the above	0.7	0.8	2.1	-1.3	-0.7	-1.2	-0.1	-0.4	-1.3	-0.8	-1.4	-0.6	0.7	-0.7	-1.1	0.0
Emphysema/chronic bronchitis	0.7	0.8	2.1	1.0	0.8	0.9	0.5	0.6	0.3	0.9	1.3	-0.6	0.8	1.4	1.4	-0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	1.2	0.8	1.2	0.7	0.9	0.7	1.1	0.8	0.1	1.2	0.8	0.8	-1.0
Ever had bowel cancer screening	0.7	0.8	2.3	0.9	0.7	1.0	0.7	0.7	1.1	0.8	1.0	-0.5	0.4	1.5	0.7	-1.2
Asthma (self-reported)	0.7	1.4	3.0	-1.1	-1.2	-1.4	-1.1	-1.0	-1.7	-1.2	-1.4	0.2	-0.9	-1.1	-1.2	1.3
Guilty feelings	0.7	1.1	2.7	0.9	1.1	0.8	1.6	1.3	0.8	1.2	1.6	0.7	-0.3	0.5	1.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	-0.8	-0.9	-0.9	-1.2	-1.0	-0.8	-0.9	-1.3	-1.5	0.6	-0.1	-0.8	0.1
Ulcerative Colitis (UC)	0.6	1.1	2.7	0.3	1.6	0.6	1.4	1.4	1.2	0.9	1.5	0.4	1.0	1.2	0.5	-0.4
Impedance of leg (right)	0.6	2.8	9.1	-0.6	-2.4	-1.6	-1.7	-2.2	-2.1	-1.4	-1.4	0.6	-0.5	-1.4	-0.8	3.0
Age when periods started (menarche)	0.6	1.4	2.3	-1.2	-1.5	-1.4	-1.4	-1.1	-0.7	-1.3	-1.3	-1.5	-0.1	-0.9	-1.3	0.4
Impedance of arm (right)	0.6	2.7	7.8	2.0	1.0	1.3	1.5	1.0	1.1	1.6	1.7	2.8	0.5	1.3	2.3	1.8
Falls in the last year	0.6	0.8	1.8	-1.1	-0.5	-1.0	-0.9	-0.6	-1.0	-0.9	0.0	-1.1	-1.3	-1.0	-0.5	0.6
Pulse rate	0.6	1.1	2.4	1.2	1.0	0.8	0.9	0.9	1.0	1.0	1.0	1.5	-1.3	-0.2	1.5	-0.1
Illnesses of mother	0.6	0.8	1.8	1.2	0.8	1.2	0.7	0.5	0.9	0.9	0.8	1.3	-1.0	0.1	0.9	-0.5
Standing height	0.6	6.2	11.9	3.2	1.5	1.7	2.7	2.0	0.0	2.6	2.0	2.5	2.0	3.3	3.5	3.2
Breastfed as a baby	0.6	0.8	1.9	0.7	0.6	0.8	1.0	0.8	0.6	0.9	0.5	0.6	1.4	1.4	1.0	0.5
Medication: Amlodipine	0.6	0.9	2.4	-0.3	-0.9	-0.9	-0.7	-0.8	-1.3	-0.6	-1.2	-1.5	0.4	0.0	-0.5	1.6
Medication: Blood pressure	0.6	1.1	6.4	-0.1	-0.6	-0.7	-0.9	-0.6	-1.2	-0.5	-0.9	-0.8	2.5	1.2	-0.1	0.8
Angina (self-reported)	0.6	0.8	3.7	-1.0	-0.5	-0.7	-0.5	-0.4	-1.0	-0.8	-1.0	0.0	1.9	0.0	-0.9	-0.4
Average weekly red wine intake	0.6	0.9	2.8	-0.8	-0.8	-0.7	-0.8	-1.0	-0.7	-0.9	-0.5	-0.8	-1.5	-0.9	-0.5	1.7
Heart disease (siblings)	0.6	0.8	2.6	1.4	0.3	0.5	0.6	0.5	0.2	0.8	0.3	1.3	1.6	1.2	0.7	0.1
Pack years of smoking	0.6	0.9	2.1	-1.2	-0.7	-1.0	-1.0	-0.7	-0.6	-1.1	-1.0	-1.4	-0.4	-1.1	-1.2	-0.4
Major Depression (MDD)	0.5	0.6	3.7	0.3	-0.0	0.3	0.2	0.2	0.7	0.3	-0.2	-1.6	-1.9	-0.7	0.2	0.2
Lupus	0.5	0.7	4.0	0.4	0.5	0.6	0.6	0.6	0.8	0.5	0.5	-0.4	2.0	1.3	0.1	-0.8
Respiratory disease	0.5	1.0	1.9	-0.7	-1.0	-1.1	-1.0	-1.0	-1.4	-0.9	-1.3	-0.7	-0.6	-0.8	-0.7	1.4
Chronotype (morning person)	0.5	1.3	3.1	-0.5	-1.7	-1.1	-1.8	-1.7	-1.2	-1.3	-1.0	-0.4	0.3	-0.1	-1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.3	0.5	0.7	0.5	0.6	0.6	1.0	0.6	0.7	0.5	1.1	1.1	0.6	0.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	3.8	0.4	0.3	-0.0	0.4	0.3	0.3	0.3	0.1	0.4	1.9	1.3	0.5	0.5
Heart attack	0.5	0.7	1.8	-0.6	-0.8	-0.9	-0.9	-0.8	-0.8	-0.7	-1.1	-1.4	0.8	0.1	-0.5	0.3
Illnesses of siblings	0.5	0.7	2.4	0.5	0.6	0.9	0.9	0.7	1.0	0.7	1.3	-0.5	-1.6	-0.0	0.4	-0.4
Medication: Cholesterol lowering	0.5	0.8	2.3	-0.3	-1.0	-0.7	-1.0	-1.0	-0.8	-0.8	-0.9	0.0	1.5	0.7	-0.6	1.0
Impedance of arm (left)	0.5	2.2	7.8	1.9	0.5	0.9	1.1	0.4	0.5	1.3	1.4	2.8	-0.2	0.8	2.1	2.4
Birth weight of first child	0.5	0.9	2.0	0.5	0.9	0.8	0.9	1.0	0.7	0.8	1.2	0.8	1.4	1.4	0.4	-0.6
Comparative body size at age 10	0.5	1.3	6.8	-1.6	0.1	-0.5	-0.6	0.0	-0.1	-0.9	-0.6	-2.6	-0.1	-0.3	-1.4	-2.0
Age at first live birth	0.5	0.8	3.8	-1.9	-0.5	-1.0	-0.4	-0.5	-0.3	-1.1	-0.5	-0.4	-0.5	-1.2	-1.4	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	0.9	1.0	1.3	1.2	1.1	0.8	1.1	0.8	1.1	-0.8	0.4	0.7	-0.8
Migraine (self-reported)	0.5	0.7	1.6	0.8	0.6	0.5	0.9	0.7	0.8	0.9	0.3	0.4	0.9	1.3	1.1	0.9
Hypertension (Self-reported)	0.5	1.4	6.3	-0.5	-0.9	-1.1	-1.1	-0.8	-1.4	-0.8	-1.4	-0.6	2.5	0.7	-0.7	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.8	-0.4	-0.7	-0.7	-0.4	-0.6	-0.6	-0.4	-0.4	0.2	1.0	0.4	0.2	1.7
Hearing aid user	0.5	0.6	1.2	0.9	0.8	0.9	0.7	0.6	0.3	0.8	0.8	0.8	0.7	1.1	0.7	0.1
Medication: Blood pressure	0.5	0.9	1.5	-0.9	-1.1	-1.2	-1.1	-1.0	-1.1	-1.0	-1.1	-0.6	0.0	-0.8	-1.2	0.7
High cholesterol (Self-reported)	0.5	1.0	2.3	-0.6	-1.1	-1.1	-1.1	-1.1	-1.1	-0.9	-0.7	-0.4	1.5	0.3	-0.6	1.3
Medication: Atorvastatin	0.5	0.6	3.0	0.5	0.5	0.4	0.4	0.4	0.2	0.4	0.6	1.2	1.7	1.1	0.7	-0.3
Illnesses of father: High blood pressure	0.5	0.7	1.4	-0.3	-1.2	-0.9	-1.0	-1.1	-0.8	-0.7	-0.7	-0.1	0.6	0.3	-0.4	1.2
Number of operations (self-reported)	0.5	0.8	1.9	-1.3	-0.8	-1.4	-0.5	-0.7	-1.1	-0.9	-0.5	-0.7	0.5	-0.2	-0.6	1.3
Depression (Nagel 2018)	0.4	0.5	1.2	-1.1	-0.4	-0.7	-0.7	-0.5	-0.5	-0.9	-0.2	-0.0	-0.9	-0.8	-1.0	-1.0
Bipolar Disorder (2011)	0.4	0.4	1.8	0.3	-0.8	-0.4	-0.6	-0.7	-0.4	-0.3	-0.3	-0.0	-0.2	-1.0	0.4	1.3
Average weekly spirits intake	0.4	0.5	3.4	-0.6	-0.4	-0.1	-0.6	-0.4	0.1	-0.5	-0.0	-0.4	-1.2	-1.8	-0.4	-0.8
Angina	0.4	0.5	3.7	-0.6	-0.3	-0.5	-0.2	-0.1	-0.7	-0.4	-0.6	0.4	1.9	0.4	-0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.9	-0.6	0.7	0.1	0.2	0.6	0.6	-0.1	0.2	1.0	-1.3	-0.6	-0.0	-1.4
High blood pressure	0.4	1.0	6.1	0.1	-0.7	-0.7	-0.8	-0.5	-1.2	-0.3	-0.9	-0.4	2.5	1.1	-0.2	1.3
High blood pressure (mother)	0.4	0.5	2.8	-0.7	-0.3	-0.5	-0.4	-0.2	-0.6	-0.6	-0.7	-0.8	1.7	0.3	-0.9	-0.6
Impedance of leg (left)	0.4	2.1	9.6	-0.1	-1.9	-1.3	-1.2	-1.7	-1.8	-0.9	-0.7	1.4	-0.3	-0.9	-0.4	3.1
Number of incorrect matches in round	0.4	0.7	4.8	0.1	-0.7	-0.4	-0.4	-0.6	-0.1	-0.3	-0.9	0.1	-2.2	-0.9	0.2	1.0
Had menopause	0.4	0.4	3.9	-0.4	-0.5	-0.4	-0.3	-0.4	-0.3	-0.4	-0.3	-2.0	-0.2	0.0	-0.8	0.1
Medication: Simvastatin	0.4	0.6	3.3	-0.3	-0.5	-0.5	-0.5	-0.5	-0.3	-0.4	-0.5	0.1	1.8	1.2	-0.2	0.9
Father’s age at death	0.4	0.6	2.4	-0.1	-0.9	-0.5	-0.6	-0.6	-0.5	-0.3	-1.2	-0.7	0.9	-0.1	-0.1	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	0.4	0.9	0.6	0.7	0.9	0.6	0.7	0.5	0.8	1.4	0.9	1.0	-0.9
Number of live births	0.4	0.6	2.7	-0.7	-0.6	-0.8	-0.5	-0.4	-0.4	-0.6	-1.2	-0.4	-1.6	-0.8	-0.7	-0.1
Asthma	0.4	0.8	1.8	-0.6	-0.9	-1.0	-0.8	-0.8	-1.3	-0.8	-0.9	0.4	-1.1	-0.8	-0.8	1.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.8	-0.5	-0.6	-0.8	-0.6	-0.4	-0.7	-0.6	-0.4	-1.3	-0.7	-0.6	-0.7	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-0.6	-0.7	-0.9	-0.4	-0.7	-0.9	-0.7	-0.3	-1.0	-0.3	-0.2	-0.6	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	0.6	1.2	1.0	0.7	0.8	1.0	0.6	0.8	1.0	-0.1	0.5	0.7	-0.9
Leg fat percentage (right)	0.4	1.4	3.7	-0.6	-1.5	-1.5	-1.4	-1.2	-1.9	-1.1	-1.2	-0.1	0.6	-0.3	-0.9	1.3
Wheeze or whistling in the chest in last year	0.4	0.7	2.9	-0.6	-0.7	-0.8	-0.6	-0.6	-0.7	-0.8	-0.5	-1.2	1.7	0.6	-0.3	1.0
Pulse wave peak to peak time	0.4	0.5	2.0	0.6	0.5	0.8	0.6	0.4	0.5	0.6	0.3	1.4	0.7	0.7	0.8	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.5	0.2	0.3	0.2	0.5	0.3	0.0	0.2	0.6	-0.1	1.6	1.6	0.2	0.4
Medication: Ibuprofen	0.4	0.5	1.0	0.2	0.8	0.7	0.8	0.8	0.7	0.6	0.6	1.0	0.7	0.3	0.9	-0.5
Medication: Omeprazole	0.4	0.5	1.0	0.9	0.8	0.5	0.8	0.8	0.0	0.8	0.9	0.6	-0.9	0.0	1.0	0.0
Family relationship satisfaction	0.4	0.4	1.4	-0.6	-0.7	-0.5	-0.7	-0.8	-1.2	-0.7	-0.7	-0.5	-0.0	-0.5	-0.7	-0.1
Leg pain on walking	0.4	0.4	1.0	-1.0	-0.7	-0.7	-0.9	-0.6	-0.3	-0.8	-0.0	-0.7	-0.4	-0.6	-0.9	0.0
Leg fat-free mass (right)	0.4	2.3	4.9	1.6	1.7	1.2	1.9	1.9	0.5	1.6	1.2	1.0	1.8	2.2	1.8	0.3
Mood swings	0.4	0.7	2.4	0.8	0.7	0.8	0.8	0.7	0.6	0.7	0.6	1.6	0.8	0.8	0.8	-0.5
Osteoporosis (self-reported)	0.4	0.5	1.3	-1.1	-0.5	-0.8	-0.7	-0.6	-0.5	-0.9	-0.1	-0.1	-0.5	-1.1	-0.8	-0.1
Leg predicted mass (right)	0.4	2.3	4.8	1.5	1.7	1.2	1.8	1.9	0.5	1.6	1.2	1.0	1.8	2.2	1.9	0.2
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.6	-0.8	-0.8	-0.8	-0.7	-0.9	-0.7	-0.6	-1.4	0.5	-0.1	-0.9	0.5
Medication: Lisinopril	0.4	0.5	3.5	0.6	0.3	0.2	0.4	0.4	-0.4	0.5	0.1	0.7	1.9	1.0	0.6	-0.1
Fractured/broken bones in last 5 years	0.4	0.6	1.6	0.4	0.9	0.5	0.9	1.0	0.5	0.7	1.0	0.1	0.2	0.7	1.3	0.6
Depressed Affect (Nagel 2018)	0.3	0.5	3.0	0.7	0.5	0.6	0.7	0.6	0.3	0.7	0.5	1.7	0.3	0.5	0.9	-0.3
Crohns Disease (2017)	0.3	0.6	1.8	0.7	0.7	0.3	0.8	0.7	0.8	0.7	0.5	0.9	1.3	1.0	0.4	0.5
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-0.7	-0.1	-0.6	-0.1	0.0	-0.3	-0.4	-0.7	-0.1	-1.3	-1.0	-0.6	-0.3
Blood White Count	0.3	1.9	4.1	0.9	1.5	1.1	1.6	1.7	2.0	1.4	1.9	1.1	0.6	0.7	1.3	-1.3
Heel T-Score	0.3	2.4	5.2	1.2	1.7	1.5	1.9	1.8	2.0	1.8	2.3	0.8	0.5	1.0	1.4	-1.3
Smoking Status	0.3	0.7	1.8	0.9	0.5	0.8	0.8	0.6	0.4	0.8	1.0	1.4	0.1	0.8	1.3	0.5
Hypothyroidism (self reported)	0.3	0.8	4.2	0.5	1.0	0.6	0.9	1.0	0.1	0.6	1.0	2.0	0.5	0.3	0.1	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.7	-1.0	-0.7	-0.9	-0.3	-0.4	0.2	-0.7	-1.3	0.6	0.2	-0.9	-0.3	0.1
Hearing difficulty/problems: Yes	0.3	0.5	2.1	0.2	0.3	0.5	0.3	0.4	0.5	0.3	0.5	0.4	1.4	0.9	-0.2	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	1.1	0.1	0.5	0.3	0.1	0.1	0.5	0.8	-0.8	-0.1	1.0	0.8	0.3
Medication: Co-codamol	0.3	0.4	3.1	-0.2	-0.2	-0.1	-0.3	-0.2	-0.2	-0.3	-0.5	-1.8	1.1	0.2	-0.2	-0.4
Leg fat-free mass (left)	0.3	1.4	3.5	1.2	1.3	0.9	1.4	1.5	0.1	1.2	0.7	0.5	1.6	1.9	1.5	0.3
Current tobacco smoking	0.3	0.5	3.2	-0.8	-0.6	-0.4	-0.7	-0.4	-0.5	-0.6	-0.9	-1.8	-0.2	-0.4	-0.4	-0.6
Average weekly fortified wine intake	0.3	0.4	0.9	-1.0	-0.3	-0.8	-0.2	-0.2	-0.8	-0.7	-0.8	-0.1	0.4	-0.8	-0.7	-0.4
Fed-up feelings	0.3	0.6	2.3	-0.0	-1.0	-0.8	-0.9	-0.9	-1.1	-0.6	-0.2	0.3	0.2	0.1	-0.2	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.5	-0.1	1.0	0.6	1.1	1.1	1.0	0.7	0.5	1.0	1.0	1.0	0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	2.0	0.3	0.5	0.6	0.3	0.5	0.6	0.4	0.2	0.2	0.3	-0.6	0.4	-1.4
Medication: Atenolol	0.3	0.3	2.6	-0.4	0.0	-0.4	-0.4	-0.0	0.1	-0.2	0.4	1.0	1.6	0.4	-0.1	0.0
Leg predicted mass (left)	0.3	1.4	3.5	1.2	1.3	0.9	1.4	1.4	0.1	1.2	0.7	0.6	1.6	1.9	1.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.3	1.1	0.4	0.7	0.2	0.3	0.3	0.7	0.6	0.8	0.0	0.7	0.7	0.0
Depression (self-reported)	0.3	0.3	0.6	0.4	0.6	0.5	0.8	0.7	0.4	0.7	0.6	0.1	0.1	0.8	0.7	-0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.4	-0.7	0.1	-0.6	-0.1	0.1	-0.1	-0.3	-0.3	-0.5	-1.2	-1.0	-0.4	0.3
Worry too long after embarrassment	0.3	0.5	2.2	-0.7	0.5	0.2	0.6	0.7	1.2	0.1	-0.4	0.6	0.4	0.2	0.1	-1.5
Shortness of breath walking on level ground	0.3	0.3	1.3	0.0	0.7	0.2	0.7	0.7	0.7	0.3	1.1	0.1	0.3	0.2	0.5	-0.5
Medication: Allopurinol	0.3	0.4	1.2	-0.8	-0.4	-0.4	-0.7	-0.4	-1.1	-0.6	-0.3	-0.5	0.0	-0.8	-0.9	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.9	-0.2	-0.2	-0.3	-0.3	-0.3	-0.1	-0.3	-1.1	1.7	-0.2	0.2	-0.1	0.1
Knee pain experienced in last month	0.3	0.5	2.1	-0.1	0.5	0.3	-0.0	0.5	1.2	0.1	0.8	-1.1	0.3	0.0	-0.2	-1.4
Friendships satisfaction	0.3	0.3	1.1	-0.6	-0.5	-0.7	-0.3	-0.5	-1.0	-0.6	-0.9	-0.6	0.0	-0.2	-0.5	0.4
Qualifications: nursing, teaching	0.3	0.4	1.0	0.8	0.7	1.0	0.5	0.6	0.8	0.6	0.9	0.5	-0.5	-0.3	0.6	-0.4
Mineral and other dietary supplements	0.3	0.4	1.8	-0.2	-0.6	-0.2	-0.5	-0.6	-0.3	-0.3	-1.4	-1.0	0.4	-0.2	-0.4	0.3
Commuting to job workplace: Public transport	0.3	0.4	1.9	0.6	0.2	0.2	0.4	0.1	-0.0	0.4	0.9	0.6	0.2	0.8	0.5	1.4
Leg fat percentage (left)	0.3	1.1	2.9	-0.5	-1.2	-1.4	-1.2	-1.0	-1.7	-1.0	-0.9	0.3	0.6	-0.2	-0.8	1.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	5.4	-0.1	0.5	0.5	0.7	0.4	0.9	0.3	0.7	0.2	-2.3	-1.0	0.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.4	0.6	0.5	0.2	0.5	0.6	-0.1	0.5	0.6	-0.5	-1.6	-0.5	0.7	-0.1
Pain experienced in last month	0.3	0.4	2.0	0.2	-0.4	0.0	-0.1	-0.5	-1.0	-0.1	-0.4	-0.4	-1.3	-0.5	0.1	1.4
Neuroticism (Nagel 2018)	0.2	0.5	2.9	-0.1	0.4	0.4	0.7	0.6	0.9	0.3	0.2	1.7	0.3	0.1	0.8	-0.9
Crohns Disease (2012)	0.2	0.3	1.6	0.1	0.2	0.1	0.4	0.2	0.0	0.2	0.2	-0.6	1.3	1.0	0.1	-0.1
Mean Putamen Volume	0.2	0.2	0.7	0.1	0.0	0.2	-0.0	-0.1	0.5	0.1	0.4	0.8	0.8	0.2	0.3	0.6
Primary Biliary Cirrhosis	0.2	0.4	0.9	-0.8	-0.6	-0.6	-0.5	-0.6	-0.3	-0.7	-0.5	-0.8	0.3	-0.2	-0.9	0.4
Blood Red Count	0.2	1.7	5.6	-0.7	-1.6	-1.7	-0.9	-1.3	-2.0	-1.1	-0.8	0.0	-1.1	-1.1	-0.7	2.4
Neuroticism	0.2	0.5	1.5	0.1	0.3	0.3	0.6	0.5	0.9	0.3	0.3	1.0	1.2	0.8	0.8	-0.6
Tanning	0.2	1.9	3.1	1.1	1.6	1.5	1.7	1.8	1.7	1.5	1.3	1.0	1.1	1.2	1.3	-1.0
Hand grip strength (left)	0.2	0.5	2.8	0.3	0.2	-0.1	0.5	0.3	-0.1	0.3	0.4	0.7	1.7	1.0	0.6	0.8
Number of treatments/medications taken	0.2	0.4	1.0	-0.6	-0.7	-0.9	-0.9	-0.7	-1.0	-0.7	-0.3	-0.1	0.6	-0.2	-0.5	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.5	-1.0	-0.0	-0.3	-0.4	-0.0	-0.1	-0.5	0.1	0.7	0.0	-0.3	-0.5	-1.2
Relative age of first facial hair	0.2	0.4	1.0	-0.8	-0.5	-0.4	-0.5	-0.4	0.0	-0.6	-0.1	0.1	-0.8	-1.0	-0.6	-0.9
Vitamin and mineral supplements	0.2	0.2	0.9	0.3	-0.4	-0.1	-0.1	-0.4	-0.6	0.0	-0.9	-0.6	0.4	0.1	0.3	0.8
Trunk fat percentage	0.2	0.6	3.3	0.6	-0.4	-0.5	-0.3	-0.3	-1.3	-0.0	0.1	1.4	0.6	0.4	0.4	1.8
Townsend deprivation index at recruitment	0.2	0.3	1.8	0.4	-0.2	0.2	-0.0	-0.1	-0.1	0.2	-0.6	1.4	-0.3	0.2	0.3	0.8
Multivitamins +/- minerals	0.2	0.3	1.1	-0.2	0.2	-0.0	0.3	0.3	0.3	0.0	1.1	0.3	-1.0	-0.3	-0.4	-0.6
Supplements: Glucosamine	0.2	0.2	0.7	-0.8	-0.2	-0.5	-0.6	-0.3	-0.2	-0.6	-0.1	0.2	-0.5	-0.6	-0.7	-0.5
Trunk fat mass	0.2	0.7	3.3	0.7	-0.1	-0.4	0.0	0.0	-1.4	0.2	0.1	1.0	1.0	0.9	0.7	1.8
Waist circumference	0.2	0.8	2.8	-0.7	-0.8	-1.2	-0.7	-0.5	-1.7	-0.8	-1.1	-1.0	0.8	-0.1	-0.8	0.8
Hearing difficulty/problems with background noise	0.2	0.3	1.0	0.4	0.0	0.2	0.4	0.2	0.1	0.3	0.5	0.6	0.9	1.0	0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.9	-0.4	-0.5	-0.2	-0.3	0.2	-0.6	-0.3	-0.6	-0.7	-0.5	-0.6	-0.4
Worrier / anxious feelings	0.2	0.4	1.1	-1.1	-0.6	-0.8	-0.5	-0.5	0.3	-0.7	-0.1	-0.1	-0.9	-0.8	-0.3	-0.0
Lung cancer (father)	0.2	0.2	1.0	0.4	0.6	0.1	0.4	0.4	0.3	0.3	-0.1	1.0	-0.7	0.0	0.2	-0.0
Length of working week for main job	0.2	0.2	1.2	1.1	-0.0	0.5	-0.0	-0.1	0.0	0.4	0.5	0.9	0.0	-0.1	0.3	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	1.2	0.4	0.8	0.6	0.4	0.4	0.9	0.6	0.5	-0.5	0.7	1.1	0.3
Medication: Paracetamol	0.2	0.3	1.0	-0.3	-0.5	-0.7	-0.6	-0.4	-0.4	-0.4	-0.7	-0.7	1.0	0.2	-0.3	0.5
Gout (self-reported)	0.2	0.3	0.8	-0.5	-0.3	-0.1	-0.4	-0.2	-0.8	-0.4	-0.3	-0.9	-0.4	-0.9	-0.5	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.8	-0.6	-0.5	-0.6	-0.2	-0.2	-0.7	-0.5	-0.4	0.2	-0.9	-0.6	-0.4	0.0
High blood pressure (siblings)	0.2	0.2	1.3	-0.3	0.1	-0.3	-0.2	-0.0	-0.1	-0.2	-0.4	1.0	1.1	-0.1	-0.1	-0.4
Body fat percentage	0.2	0.6	2.4	0.1	-0.6	-0.8	-0.6	-0.5	-1.5	-0.3	-0.3	1.0	0.8	0.2	-0.0	1.6
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.8	0.3	-0.3	0.2	0.4	0.2	-0.2	0.5	0.6	0.0	-0.4	-0.0	-0.8
Pulse rate, automated reading	0.2	0.7	2.9	1.1	0.6	0.7	0.6	0.7	0.4	0.8	0.3	0.8	-1.7	0.1	1.2	-0.0
Number of full sisters	0.2	0.3	1.2	-1.1	-0.2	-0.6	-0.4	-0.4	-0.3	-0.8	-0.4	0.4	0.5	-0.0	-0.7	-0.3
Chest pain or discomfort	0.2	0.3	1.8	-1.0	-0.2	-0.7	-0.3	-0.1	0.0	-0.5	0.2	-0.5	1.3	-0.4	0.1	0.0
Supplements: Vitamin C	0.2	0.2	2.0	0.4	-0.0	0.3	0.0	-0.0	0.3	0.1	0.8	1.4	0.1	0.1	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	3.0	0.5	-0.1	-0.4	0.3	-0.0	-0.8	0.1	-0.0	0.9	-0.2	0.0	0.8	1.7
Whole body fat-free mass	0.2	0.9	3.1	0.8	0.9	0.4	1.0	1.1	-0.3	0.8	0.3	0.1	1.7	1.8	1.0	0.5
Long-standing illness, disability or infirmity	0.2	0.3	1.6	0.5	-0.1	-0.1	-0.1	0.1	-0.5	0.2	-0.2	-0.5	0.8	1.2	0.6	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.0	-0.4	-0.2	-0.3	-0.3	-0.9	-0.2	-0.2	0.1	0.9	0.9	-0.7	0.0
Medication for cholesterol	0.2	0.3	0.9	-0.1	-0.7	-0.3	-0.7	-0.7	-0.4	-0.4	-1.0	-0.5	0.4	-0.2	-0.3	0.2
Smoking status: Current	0.2	0.3	2.2	-0.7	-0.3	-0.2	-0.5	-0.2	-0.3	-0.5	-0.6	-1.5	-0.1	-0.3	-0.3	-0.7
Whole body water mass	0.2	0.9	3.1	0.8	0.9	0.5	1.0	1.1	-0.3	0.9	0.4	0.1	1.6	1.8	1.1	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.3	-0.5	-0.4	-0.4	-0.3	-0.6	-0.0	-0.5	-0.8	0.7	0.5	-0.1	1.0
Wears glasses or contact lenses	0.2	0.2	1.0	-0.4	0.2	0.3	0.2	0.2	1.0	0.0	0.2	0.2	0.4	0.4	-0.2	-0.6
Mother’s age at death	0.2	0.2	1.0	-0.3	0.0	-0.0	0.1	-0.0	-0.1	-0.2	-0.4	-1.0	0.1	0.3	-0.6	-0.9
Diastolic blood pressure, automated reading	0.2	0.5	1.0	-0.9	-0.5	-0.9	-0.9	-0.4	-0.8	-0.9	-0.4	0.6	0.8	-0.5	-1.0	-0.7
Myopia	0.2	0.3	1.2	-0.7	-0.5	-0.5	-0.2	-0.2	0.1	-0.4	-0.4	-0.5	0.3	-0.3	-1.1	-0.7
Cholesterol lowering medication	0.2	0.3	0.8	-0.7	-0.5	-0.9	-0.3	-0.4	-0.6	-0.5	-0.2	0.5	0.8	0.5	-0.1	0.9
Impedance of whole body	0.2	1.2	7.7	0.9	-0.7	-0.1	-0.0	-0.7	-0.7	0.2	0.6	2.0	-0.4	-0.1	0.9	2.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.0	-0.6	-0.2	-0.9	-0.1	-0.2	-0.5	-0.4	0.0	-0.8	-0.0	0.3	-0.2	1.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	-0.3	-0.1	-0.5	-0.5	-0.4	-0.2	-0.3	-0.2	0.1	-0.0	-0.5	0.6
Worry (Nagel 2018)	0.1	0.2	0.7	-0.9	-0.4	-0.5	-0.1	-0.3	0.4	-0.6	-0.3	0.8	0.3	-0.3	-0.0	-0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.1	0.4	0.1	0.3	0.4	0.3	0.2	-0.0	-0.4	-0.6	-0.3	0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.3	0.4	0.3	0.2	0.3	0.3	0.3	0.5	-0.7	0.3	0.6	-0.0	-0.6
Breast Cancer	0.1	0.3	2.4	0.5	-0.2	-0.2	-0.1	-0.3	-0.1	-0.1	-0.1	-0.5	0.7	0.7	0.5	1.5
Age at First Birth	0.1	0.1	0.3	0.5	0.2	0.2	0.3	0.2	0.6	0.4	0.3	0.3	0.3	0.3	0.4	0.3
LDL Cholesterol	0.1	0.2	1.2	0.1	-0.3	-0.4	-0.4	-0.3	-0.2	-0.2	0.6	0.6	-0.2	-0.1	0.1	1.1
Blood Eosinophil Count	0.1	0.5	1.5	1.1	-0.1	0.4	0.4	0.1	0.5	0.6	0.5	1.2	0.1	0.5	0.9	1.2
Blood Platelet Count	0.1	1.0	4.1	0.2	-1.7	-0.5	-0.7	-0.9	-0.6	-0.4	-1.0	-0.0	-1.1	-1.6	-0.3	2.0
Allergy or Eczema	0.1	0.2	0.4	0.6	0.6	0.6	0.5	0.4	0.4	0.5	-0.1	0.2	-0.6	0.3	0.3	-0.0
Maternal smoking around birth	0.1	0.2	1.4	-0.3	0.3	0.1	0.1	0.3	-0.0	-0.1	0.4	-0.7	0.0	-0.4	-0.3	-1.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-0.1	-0.2	-0.1	-0.4	-0.3	-0.3	-0.2	-0.5	-0.6	-0.9	-0.4	-0.3	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.0	0.3	0.0	0.2	0.3	0.1	0.2	0.5	-0.6	-0.5	0.2	0.0	-0.3
Body mass index (BMI)	0.1	0.5	1.4	-0.8	-0.6	-1.0	-0.9	-0.5	-1.2	-0.8	-0.9	-0.5	0.5	-0.3	-0.8	-0.1
Alcohol usually taken with meals	0.1	0.1	0.5	0.2	0.1	0.2	0.1	-0.0	-0.2	0.1	0.7	-0.6	-0.6	-0.4	0.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.7	-0.3	-0.5	-0.7	-0.5	-0.4	-0.7	-0.3	0.1	0.6	-0.5	-0.3	0.1
Had other major operations	0.1	0.2	0.9	-0.1	0.4	0.3	0.3	0.2	0.2	0.1	-0.2	-0.7	1.0	0.4	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.6	-0.4	0.4	0.1	0.4	0.5	0.2	0.1	-0.0	0.6	1.3	0.4	-0.0	-0.8
Qualifications: None of the above	0.1	0.3	1.7	0.6	0.2	0.2	0.3	0.3	0.3	0.4	0.2	1.3	0.4	0.2	0.9	-0.2
Financial difficulties in last 2 years	0.1	0.1	0.7	-0.3	0.1	0.1	0.1	0.2	0.4	0.1	-0.1	0.5	-0.8	-0.6	-0.4	-0.2
Fluid intelligence score	0.1	0.2	0.5	0.6	0.5	0.7	0.1	0.2	0.3	0.4	0.3	-0.4	0.1	0.5	0.3	-0.4
Neuroticism score	0.1	0.3	2.9	-0.0	-0.3	-0.2	0.2	-0.0	0.1	0.0	0.1	1.7	0.6	0.2	0.7	0.2
Weight	0.1	0.7	1.8	0.8	0.2	-0.1	0.4	0.5	-1.1	0.5	0.1	0.6	1.3	1.2	0.8	1.3
Arm fat percentage (right)	0.1	0.3	0.8	0.4	0.2	-0.3	0.0	0.2	-0.7	0.2	-0.0	0.9	0.8	0.5	0.5	0.7
Trunk fat-free mass	0.1	0.6	2.4	0.5	0.5	0.1	0.7	0.8	-0.5	0.5	-0.0	-0.4	1.6	1.6	0.7	0.7
Hip circumference	0.1	0.4	1.3	0.5	0.4	-0.0	0.4	0.6	-0.7	0.4	0.3	1.1	0.9	0.9	0.8	0.7
Prospective memory result	0.1	0.1	0.5	-0.1	-0.2	-0.3	-0.0	-0.1	-0.2	-0.2	-0.7	0.3	-0.5	-0.2	-0.1	0.7
Arm fat mass (right)	0.1	0.3	1.4	0.3	-0.1	-0.5	-0.2	0.0	-1.2	-0.0	-0.3	0.4	0.8	0.5	0.4	1.0
Trunk predicted mass	0.1	0.7	2.6	0.5	0.6	0.1	0.7	0.9	-0.5	0.6	-0.0	-0.4	1.6	1.6	0.7	0.5
Tense / ‘highly strung’	0.1	0.2	0.7	0.2	-0.0	-0.0	0.4	0.1	0.6	0.2	0.4	0.6	0.8	0.2	0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.2	0.3	0.2	0.3	0.4	0.5	0.2	0.3	0.4	0.6	0.4	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.8	0.0	-0.0	-0.3	-0.1	0.1	-0.9	-0.1	0.3	1.3	0.2	-0.0	-0.6	0.1
Arm fat-free mass (right)	0.1	0.4	1.7	0.1	-0.1	-0.4	0.1	0.2	-1.3	-0.0	-0.4	-0.8	1.0	0.8	0.1	0.9
Heart disease (mother)	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.2	0.2	-0.4	-0.0	0.0	-0.1	-0.2	-0.6	-0.2	0.1
Whole body fat mass	0.1	0.6	2.0	0.4	-0.2	-0.5	-0.1	-0.0	-1.4	-0.0	-0.2	0.8	1.2	0.7	0.4	1.4
Leg fat mass (right)	0.1	0.5	2.4	-0.1	-0.6	-0.8	-0.6	-0.3	-1.6	-0.4	-0.6	0.2	1.2	0.4	-0.2	0.9
Arm predicted mass (right)	0.1	0.4	1.5	0.1	-0.1	-0.4	0.1	0.2	-1.2	-0.0	-0.3	-0.8	0.9	0.8	0.1	0.8
Overall health rating	0.1	0.2	0.8	-0.7	0.1	-0.5	-0.3	0.2	0.1	-0.3	-0.1	-0.1	0.9	0.5	-0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	1.0	-0.3	-0.2	-0.5	-0.2	-0.4	-0.4	-0.3	-0.1	0.1	-0.1	0.0	0.3	1.0
Arm fat percentage (left)	0.1	0.3	1.0	0.4	0.1	-0.3	0.0	0.2	-0.8	0.2	0.1	1.0	0.8	0.5	0.5	0.8
Arm fat mass (left)	0.1	0.3	1.2	0.4	-0.0	-0.5	-0.1	0.1	-1.1	0.1	-0.2	0.5	0.9	0.6	0.4	0.9
Financial situation satisfaction	0.1	0.2	1.5	-0.4	0.3	0.1	0.0	0.3	0.3	-0.1	0.5	0.2	0.0	-0.3	-0.3	-1.2
Alcohol drinker status: Never	0.1	0.1	0.6	-0.2	0.1	-0.1	0.1	0.2	0.6	0.1	0.4	0.7	0.7	0.3	0.0	0.3
Basal metabolic rate	0.1	0.7	2.3	0.7	0.6	0.2	0.8	0.9	-0.7	0.7	0.2	0.2	1.5	1.5	1.0	0.9
Arm fat-free mass (left)	0.1	0.4	1.9	0.3	0.4	-0.0	0.5	0.7	-0.8	0.3	-0.1	-0.4	1.4	1.2	0.4	0.3
Age started oral contraceptive pill	0.1	0.2	0.6	-0.8	-0.4	-0.3	-0.3	-0.4	-0.1	-0.5	-0.3	-0.1	0.3	-0.3	-0.7	-0.0
Leg fat mass (left)	0.1	0.5	2.2	0.0	-0.4	-0.7	-0.4	-0.2	-1.5	-0.3	-0.4	0.3	1.1	0.5	-0.1	1.0
Arm predicted mass (left)	0.1	0.3	1.6	0.1	0.1	-0.3	0.2	0.4	-1.0	0.1	-0.1	-0.4	1.3	1.0	0.2	0.5
BMI	0.0	0.2	0.4	-0.6	-0.0	-0.6	-0.4	-0.0	-0.1	-0.5	-0.7	-0.0	-0.4	-0.5	-0.6	-0.4
Hair Pigment	0.0	0.3	2.0	0.2	-0.4	-0.6	-0.1	-0.3	-0.1	-0.2	0.0	0.5	0.8	0.6	0.3	1.4
Taking other prescription medications	0.0	0.0	0.2	0.3	-0.1	-0.2	-0.2	-0.1	-0.1	0.1	-0.1	0.4	-0.1	-0.1	0.2	0.3
Back pain experienced in last month	0.0	0.1	0.2	0.0	-0.3	-0.1	-0.3	-0.3	-0.2	-0.2	-0.4	-0.4	-0.4	-0.1	-0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.2	-0.1	-0.1	-0.0	-0.3	-0.1	0.1	-0.1	-0.4	-0.1	-0.1	0.4	-0.0	-0.4

Hub : Genes

SEC61A2

Models

Trait associations