Hub : Genes

CDC123

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0644 0.0140 1.3e-10 0.039 0.038 0.037 0.044 0.040 1.2e-12 1.9e-12 3.8e-12 4.7e-14 5.2e-13
2 YFS Blood 0.0756 0.0175 2.6e-10 0.031 0.044 0.059 0.048 0.050 1.7e-10 3.3e-14 9.6e-19 1.7e-15 5.1e-16
3 TCGA Pheochromocytoma and Paraganglioma 0.2580 0.1090 2.9e-03 0.067 0.063 0.060 NA 0.065 1.2e-03 1.7e-03 2.2e-03 NA 1.4e-03
4 TCGA Soft Tissue Sarcoma 0.0830 0.0480 9.3e-03 -0.003 0.034 0.002 NA -0.002 5.7e-01 4.0e-03 2.4e-01 NA 4.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 1.5 -0.7 -1.0 1.2 -1.1
Bipolar Disorder or Schizophrenia 1.8 4.3 7.6 -1.2 -2.0 2.8 -2.0
Depressed Affect (Nagel 2018) 0.2 0.5 1.8 -0.1 -1.3 -0.1 -0.3
Depression (Nagel 2018) 0.5 0.8 2.2 -0.2 -1.5 0.7 0.5
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 0.3 0.5 -0.9 -0.8
Neuroticism (Nagel 2018) 0.3 0.7 2.4 0.2 -1.5 -0.1 0.4
Schizophrenia (2018) 1.7 3.5 6.6 -1.0 -1.9 2.6 -1.8
Schizophrenia vs Biploar Disorder 0.1 0.2 0.4 0.4 0.0 -0.4 -0.6
Worry (Nagel 2018) 0.4 0.9 1.5 0.7 -1.2 -0.7 1.0
Alzheimer’s Disease (in mother) 0.6 0.7 2.2 -0.5 0.2 1.5 -0.6
Alzheimer’s Disease (in father) 2.1 2.3 3.4 1.8 0.6 -1.6 1.6
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.7 -0.1 -0.3 0.4
Crohns Disease (2017) 0.3 0.8 2.0 1.4 0.8 -0.4 0.3
Irritable Bowel Disease (IBD) 0.4 0.9 1.9 1.1 1.4 0.8 -0.1
Ulcerative Colitis (UC) 0.7 1.2 3.1 0.3 1.2 1.8 -0.6
Major Depression (MDD) 3.4 4.1 7.1 -2.0 -2.7 1.6 -1.6
Reaction Time 0.1 0.2 0.3 0.5 -0.1 0.2 -0.6
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 0.6 0.7 -0.4 -0.2
Breast Cancer 0.3 0.8 1.2 0.7 1.0 -1.1 0.9
Ovarian Cancer 0.3 0.4 1.6 0.2 -0.2 1.3 -0.1
Prostate Cancer 1.4 1.9 5.3 -1.5 -2.3 0.0 0.5
Age at First Birth 0.2 0.4 0.8 0.9 -0.0 -0.4 0.7
Bipolar Disorder (2011) 2.1 2.0 4.9 -0.7 -1.6 2.2 0.5
Body Mass Index (BMI) (2010) 0.6 0.9 2.0 -1.4 -0.9 0.7 -0.4
Coronary Artery Disease (CAD) 2.1 2.5 5.3 0.3 1.9 -2.3 0.9
Crohns Disease (2012) 1.0 1.5 3.8 1.9 1.0 -1.0 0.6
Mean Putamen Volume 0.3 0.4 0.7 0.5 0.1 -0.8 -0.8
Fasting Glucose 4.2 5.0 10.0 1.8 2.0 -3.2 1.5
HbA1C 3.8 4.2 8.5 1.9 0.6 -2.0 2.9
HDL Cholesterol 0.3 0.5 1.7 -0.3 -0.3 -0.6 -1.3
LDL Cholesterol 0.4 0.6 1.4 -0.7 0.0 1.2 -0.5
Lupus 2.8 4.3 8.0 2.7 1.2 -0.5 2.8
Neuroticism (2016) 1.3 1.9 2.6 -1.1 -1.6 1.6 -1.1
Primary Biliary Cirrhosis 1.4 1.9 5.3 2.3 0.4 -1.2 0.9
Rheumatoid Arthritis 0.5 0.7 1.9 0.2 0.0 1.4 -0.9
Schizophrenia (2014) 2.6 5.7 7.8 -1.6 -2.8 2.7 -2.3
Triglycerides 0.3 0.5 1.0 0.3 0.7 -0.5 1.0
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.2 0.7 2.1 -1.5 1.2
Ulcerative Colitis 0.6 0.9 1.6 -0.3 0.8 1.3 -1.0
Blood Eosinophil Count 0.1 0.7 1.8 -0.0 -0.8 1.3 0.7
Blood Platelet Count 0.3 3.3 9.4 -0.9 -3.1 1.7 -0.1
Blood Red Count 0.1 1.1 2.1 -0.9 -1.4 0.7 -1.0
Blood White Count 0.1 0.8 1.8 -0.2 -0.8 0.8 -1.3
Heel T-Score 0.0 0.2 0.5 0.3 0.2 0.7 -0.0
BMI 0.1 0.8 2.1 1.5 0.3 -0.1 1.1
Height 0.7 14.4 32.9 -4.2 -1.8 1.9 -5.7
Waist Hip Ratio (WHR) 0.3 1.1 2.1 0.9 -1.4 0.0 1.3
Systolic Blood Pressure 3.6 18.2 24.5 5.0 3.5 -3.6 4.8
Smoking Status 0.6 1.4 2.4 -0.9 -1.4 -0.3 -1.6
Allergy or Eczema 0.3 0.7 1.1 -0.7 0.3 1.0 -1.1
Cardiovascular Disease 1.5 4.8 10.4 3.2 1.5 -1.8 1.8
Hypothyroidism (self reported) 0.3 0.7 1.8 -0.0 0.6 0.8 1.3
Respiratory disease 0.0 0.0 0.1 -0.0 -0.3 0.3 -0.1
Type 2 Diabetes (T2D) (2018) 6.1 11.4 31.5 2.1 2.4 -5.6 2.1
Lung FEV1/FVC ratio 49.4 250.4 334.9 -18.3 -15.0 15.5 -14.2
Lung FVC 8.2 41.7 52.8 -7.3 -5.3 6.4 -6.7
Neuroticism 0.6 1.5 3.8 1.4 -0.2 -2.0 0.7
Chronotype (morning person) 2.0 4.5 6.7 2.2 1.4 -2.2 2.6
Hair Pigment 0.0 1.1 2.8 0.6 1.0 -0.5 1.7
Tanning 0.1 1.3 3.4 -1.2 -0.7 0.2 -1.9
Hand grip strength (left) 0.1 0.4 1.1 1.1 0.4 -0.5 0.2
Number of treatments/medications taken 1.0 1.8 3.6 1.4 0.2 -1.3 1.9
Average weekly spirits intake 1.0 1.2 2.3 -1.5 -1.5 0.7 -0.2
Sensitivity / hurt feelings 0.2 0.4 0.7 0.5 -0.5 -0.9 0.6
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.5 1.6 -1.1 -0.0 1.1
Hearing difficulty/problems: Yes 1.7 2.6 4.8 2.2 1.3 -0.9 1.8
Relative age of first facial hair 0.1 0.2 0.4 0.2 -0.6 0.5 0.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.7 0.8 -0.4 -0.3 1.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 0.5 0.2 -0.8 -0.2
Ever had hysterectomy (womb removed) 0.5 0.6 2.0 0.4 0.4 -1.4 -0.1
Systolic blood pressure, automated reading 4.8 13.9 18.0 3.7 2.9 -3.9 4.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.4 -1.6 -1.3 -0.3 0.4
Angina 2.9 3.8 7.8 2.2 1.3 -2.8 0.9
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.0 0.4 0.5 -0.0
Vitamin and mineral supplements 0.1 0.1 0.3 0.5 0.2 -0.5 -0.1
Supplements: Zinc 3.5 3.8 7.4 -1.7 -1.2 2.7 -1.8
Medication: Co-codamol 1.2 1.4 3.2 0.9 0.4 -1.8 1.1
Medication: Metformin 5.4 7.6 19.7 1.8 2.0 -4.4 1.9
Diabetes (father) 0.7 0.9 3.3 -0.1 0.5 -1.8 -0.2
Diabetes (mother) 12.8 16.4 30.8 4.0 2.8 -5.5 3.3
Severe depression (siblings) 0.8 0.9 2.3 1.5 -0.7 1.0 0.1
Pack years adult smoking proportion 1.2 1.9 4.3 2.1 0.2 -0.5 1.7
Impedance of leg (right) 0.2 1.2 2.6 -1.4 -1.6 0.3 0.5
Leg fat-free mass (left) 0.1 0.8 2.1 0.2 1.0 -0.2 -1.4
Trunk fat percentage 0.0 0.0 0.1 0.2 0.2 -0.1 0.2
Hand grip strength (right) 0.2 0.6 1.1 0.8 0.4 -0.8 -1.0
Townsend deprivation index at recruitment 0.1 0.2 0.3 -0.4 -0.4 -0.6 -0.5
Current tobacco smoking 0.4 0.7 2.4 0.0 -0.4 -1.6 -0.2
Average weekly fortified wine intake 1.6 1.9 6.7 0.9 0.2 -0.2 2.6
Maternal smoking around birth 0.0 0.0 0.1 0.3 0.1 0.2 0.3
Fed-up feelings 0.4 0.8 2.3 0.8 -0.2 -1.5 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 2.9 -1.0 -1.7 1.2 -0.9
Relative age voice broke 0.3 0.5 0.9 0.3 -0.6 0.9 -0.9
Taking other prescription medications 0.6 0.9 1.7 -0.2 -1.3 0.6 1.2
Age when periods started (menarche) 0.1 0.3 0.7 0.4 -0.1 -0.8 -0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.2 0.5 1.1 -0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.3 1.2 1.8 -1.3 0.3
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.5 1.9 1.1 -0.1 1.1
Qualifications: CSEs or equivalent 1.0 1.3 3.7 0.4 -0.3 -1.1 1.9
Serious illness, injury or assault to yourself 0.9 1.1 2.6 0.5 -1.6 -1.0 0.9
High blood pressure 1.9 5.3 8.1 2.8 2.2 -2.3 1.7
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.1 0.3 0.9 -0.3
Multivitamins +/- minerals 0.4 0.6 1.0 -0.2 -0.9 1.0 0.6
Stomach or abdominal pain in last month 1.0 1.3 2.6 1.4 -0.4 0.4 1.6
Supplements: Glucosamine 0.2 0.3 0.6 0.3 0.6 -0.5 0.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 0.1 -1.2 0.8 -0.4
Medication: Atenolol 3.2 4.0 6.5 2.6 2.1 -1.4 1.7
Medication: Levothyroxine sodium 1.6 2.8 8.4 1.2 0.7 -0.9 2.9
Sitting height 0.7 5.3 13.0 -2.3 -1.0 1.4 -3.6
Chronic bronchitis/emphysema (father) 0.6 0.6 1.9 1.4 -0.2 0.5 0.7
High blood pressure (mother) 3.6 5.0 11.9 3.4 0.2 -1.2 2.6
Body mass index (BMI) 0.6 2.7 4.2 2.0 1.4 -1.4 1.6
Impedance of leg (left) 0.3 1.6 3.6 -1.4 -1.9 0.8 0.5
Leg predicted mass (left) 0.2 0.8 2.1 0.1 1.0 -0.2 -1.5
Trunk fat mass 0.0 0.1 0.2 0.3 0.5 -0.3 -0.2
Waist circumference 0.5 1.8 3.7 1.9 0.9 -0.8 1.4
Number of incorrect matches in round 1.4 2.3 4.2 -1.1 -2.0 2.0 0.1
Past tobacco smoking 0.5 0.8 2.2 0.3 1.0 0.3 1.5
Alcohol usually taken with meals 1.1 1.7 4.0 -2.0 -0.8 1.4 -0.6
Nervous feelings 0.9 1.8 5.1 -0.3 -1.3 -0.5 2.3
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 2.2 1.2 -1.5 -0.3 1.0
Hearing difficulty/problems with background noise 0.5 0.9 1.4 1.2 0.7 -1.0 0.8
Hair/balding pattern: Pattern 2 0.6 0.7 1.4 -0.0 -1.2 0.8 -1.0
Had menopause 0.4 0.4 0.9 0.3 -1.0 -0.8 0.3
Had other major operations 0.3 0.4 1.0 -0.6 1.0 -0.3 -0.4
Forced vital capacity (FVC) 7.4 28.3 40.2 -5.5 -4.1 5.1 -6.3
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.7 1.3 1.9 -1.2 1.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.2 0.1 -1.1 -0.3 0.4
Qualifications: None of the above 0.3 0.6 1.6 -0.9 -1.2 0.4 0.1
Financial difficulties in last 2 years 0.5 0.7 1.7 -0.1 -0.8 1.3 0.6
Mouth/teeth dental problems 1.4 2.1 4.3 -1.2 -1.3 2.1 -1.0
Heart attack 2.9 3.8 9.4 1.4 1.3 -3.1 1.3
Allergy 0.0 0.1 0.2 0.4 0.2 -0.4 -0.3
Pain all over the body in last month 0.2 0.2 0.4 0.3 0.5 -0.4 -0.7
Diabetes (self-reported) 2.6 4.0 11.4 0.4 1.6 -3.4 1.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 -0.3 0.1 0.2 -1.2
Medication: Ramipril 6.5 8.3 11.5 3.4 1.8 -3.4 2.7
Medication: Simvastatin 1.7 2.5 4.6 1.3 1.7 -2.2 1.0
Fluid intelligence score 0.2 0.5 1.3 -0.6 0.1 0.6 -1.2
Illnesses of siblings 2.4 3.4 5.0 -2.2 -0.9 2.1 -1.9
Neuroticism score 0.5 1.0 1.5 0.9 -1.0 -1.2 0.7
Weight 0.1 0.4 0.7 0.7 0.9 -0.6 -0.4
Impedance of arm (right) 0.9 4.0 6.5 -2.5 -1.0 2.0 -2.2
Arm fat percentage (right) 0.2 0.7 1.8 0.8 1.3 -0.4 0.3
Trunk fat-free mass 0.1 0.8 1.3 0.5 1.2 -0.8 -1.0
Hip circumference 0.2 0.7 1.9 0.8 1.4 -0.5 -0.1
Time employed in main current job 0.3 0.3 0.4 0.7 0.5 -0.5 0.5
Alcohol intake versus 10 years previously 2.5 3.7 5.9 1.9 2.3 -2.4 0.0
Father’s age at death 0.2 0.2 0.8 -0.9 -0.3 -0.3 -0.2
Worrier / anxious feelings 0.2 0.4 1.1 -0.3 -1.0 -0.6 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.2 1.5 -1.1 -1.1 -0.1
Falls in the last year 0.2 0.3 0.6 -0.2 -0.7 0.8 -0.2
Hair/balding pattern: Pattern 3 0.6 0.9 3.1 -0.2 -0.1 0.5 1.8
Number of live births 0.2 0.3 1.0 -0.6 -0.0 1.0 0.1
Forced expiratory volume in 1-second (FEV1) 22.2 75.0 93.1 -9.6 -7.4 8.7 -8.7
Pulse rate 1.9 3.1 6.5 -1.5 -1.6 2.6 -1.1
Happiness 0.7 0.9 1.8 -1.2 -1.3 0.3 0.5
Noisy workplace 0.5 0.6 1.2 0.5 -0.6 -0.7 1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.2 1.1 0.9 0.7 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.7 -0.8 -0.5 0.1 -0.9
Mouth/teeth dental problems: Dentures 0.8 1.4 2.7 0.6 1.0 -1.6 1.3
Asthma 0.3 0.5 1.6 -1.2 -0.3 0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.3 0.3 0.3 -0.4
Medication: Cholesterol lowering 2.0 3.2 6.9 1.7 1.4 -2.6 1.0
Depression (self-reported) 0.4 0.5 1.4 -0.2 -0.6 0.1 -1.2
Medication: Lansoprazole 0.6 0.6 1.8 -0.4 -1.3 0.7 0.2
Prospective memory result 0.2 0.2 0.4 -0.7 0.5 0.3 -0.3
Lung cancer (father) 1.6 1.9 6.3 0.4 -0.4 2.5 1.0
Illnesses of mother 4.1 5.1 12.7 -3.6 -0.5 1.5 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 21.6 69.0 81.6 -9.0 -7.4 8.6 -8.1
Pulse wave Arterial Stiffness index 1.3 1.5 2.3 1.5 0.3 1.1 1.5
Impedance of arm (left) 1.1 5.3 7.6 -2.8 -2.1 2.1 -2.2
Arm fat mass (right) 0.1 0.5 1.0 0.8 1.0 -0.6 0.2
Trunk predicted mass 0.1 0.8 1.4 0.6 1.2 -0.8 -1.0
Standing height 0.7 7.2 16.2 -2.9 -1.3 1.6 -4.0
Length of working week for main job 0.1 0.1 0.2 0.1 -0.4 0.2 -0.3
Exposure to tobacco smoke at home 1.3 1.4 1.9 1.0 1.4 -1.4 -1.0
Breastfed as a baby 0.2 0.3 0.6 0.0 0.4 -0.6 -0.7
Tense / ‘highly strung’ 0.2 0.3 1.0 1.0 -0.3 -0.3 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.9 -0.1 -1.7 0.8 -0.0
Hair/balding pattern: Pattern 4 0.4 0.9 2.0 -1.2 -0.3 -0.1 -1.4
Birth weight of first child 0.4 0.7 2.6 0.3 1.6 0.1 -0.2
Peak expiratory flow (PEF) 18.8 43.6 58.1 -7.6 -5.0 6.5 -7.0
Pulse wave reflection index 2.4 2.9 5.7 2.4 1.0 -0.8 2.1
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.6 1.4 0.5 -1.0 1.6
Loud music exposure frequency 1.6 1.8 2.8 0.2 -1.7 1.2 1.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.3 -0.1 -0.4 1.2 -0.1
Mouth/teeth dental problems: Bleeding gums 2.3 3.0 6.0 2.5 0.7 -1.7 1.6
Blood clot in the leg (DVT) 0.4 0.5 1.3 -0.6 -1.1 -0.1 -0.7
Medication: Paracetamol 1.7 2.8 6.8 2.6 -0.9 -1.5 1.3
Headache pain in last month 0.7 1.2 3.9 0.1 -0.9 2.0 -0.3
Medication for cholesterol, blood pressure or diabetes 3.6 6.0 12.1 -2.5 -1.8 3.5 -1.7
Glaucoma (self-reported) 0.8 1.0 1.6 -1.3 -0.3 1.0 -1.1
Gout (self-reported) 0.0 0.1 0.1 0.2 0.2 -0.4 -0.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 4.1 -0.1 0.7 0.1 2.0
Medication: Amlodipine 0.4 0.6 2.3 0.1 0.0 -1.5 -0.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 -0.3 0.3 0.1 0.7
Birth weight 1.8 3.8 8.2 2.2 2.9 -1.1 1.1
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.7 0.7 -1.3 1.1 0.3
High blood pressure (siblings) 2.0 2.8 6.1 2.5 -0.3 -0.4 2.2
Forced vital capacity (FVC), Best measure 7.0 25.5 34.7 -5.2 -4.0 4.9 -5.9
Body fat percentage 0.1 0.5 0.7 0.8 0.7 -0.7 0.6
Leg fat percentage (right) 0.5 1.8 3.0 1.4 0.9 -1.7 1.2
Arm fat-free mass (right) 0.1 0.5 0.8 0.7 0.6 -0.9 -0.6
Exposure to tobacco smoke outside home 0.7 0.9 2.3 1.5 0.4 -0.5 -0.9
Comparative body size at age 10 1.9 5.4 8.3 2.9 2.1 -1.9 2.3
Number of full brothers 0.4 0.4 1.3 0.3 0.6 -0.1 -1.2
Worry too long after embarrassment 0.3 0.5 1.2 1.1 0.1 -0.3 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.1 -1.0 -1.3 0.7 -1.8
Wheeze or whistling in the chest in last year 1.7 3.1 4.7 2.2 1.4 -1.9 1.3
Number of children fathered 1.3 1.5 3.5 -1.9 -1.1 1.0 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 1.8 0.0 0.8 -1.4 -1.0
Age at first live birth 0.2 0.3 0.5 0.7 0.4 0.3 0.7
Pulse wave peak to peak time 1.4 1.7 3.0 -1.7 -0.4 -1.0 -1.6
Health satisfaction 1.6 2.1 3.7 1.9 -0.3 -1.5 1.5
Shortness of breath walking on level ground 0.6 0.8 2.3 0.2 -1.5 0.7 -0.5
Qualifications: College or University degree 0.0 0.2 0.3 -0.1 -0.6 0.5 -0.1
Eye problems/disorders: None of the above 1.2 1.3 3.1 1.3 0.6 -0.3 1.8
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.2 0.4 1.8 -1.6 -0.7
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.2 0.2 -0.4 -0.5
Medication for pain relief, constipation, heartburn 1.4 2.4 4.4 -2.0 0.1 1.2 -2.1
Neck or shoulder pain in last month 0.6 0.8 2.5 0.3 0.3 -1.6 0.8
Medication: Blood pressure 3.6 6.3 9.7 2.8 2.2 -3.1 1.7
Angina (self-reported) 4.0 5.3 9.6 2.7 1.4 -3.1 1.5
Migraine (self-reported) 0.5 0.6 1.2 -0.2 -1.1 0.1 -1.1
Medication: Ibuprofen 0.2 0.3 0.5 -0.0 -0.3 0.7 -0.6
Medication: Allopurinol 0.5 0.7 1.4 0.7 1.2 -0.8 0.4
Medication: Omeprazole 2.0 2.4 3.8 -1.9 -1.2 1.9 -0.8
Medication: Seretide 50 evohaler 0.2 0.2 0.6 -0.3 0.8 0.2 -0.1
Mean time to correctly identify matches 0.2 0.5 1.2 1.1 0.6 -0.3 -0.3
Heart disease (mother) 0.1 0.1 0.4 0.1 0.3 -0.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.1 0.7 1.2 -0.4 1.8
Whole body fat mass 0.1 0.4 0.6 0.7 0.8 -0.7 -0.0
Leg fat mass (right) 0.3 1.2 2.1 1.2 1.1 -1.4 0.4
Arm predicted mass (right) 0.1 0.4 0.6 0.8 0.4 -0.7 -0.5
Pulse rate, automated reading 1.9 6.0 9.8 -3.0 -1.8 1.4 -3.1
Alcohol intake frequency. 0.5 1.1 2.7 -0.4 -1.2 1.6 0.4
Comparative height size at age 10 1.3 7.0 16.2 -3.0 -0.0 1.8 -4.0
Number of full sisters 0.7 0.9 2.0 1.4 -0.6 -0.9 0.6
Suffer from ‘nerves’ 0.5 0.9 2.5 0.9 -1.6 0.1 0.4
Overall health rating 1.7 3.6 7.0 2.6 1.4 -1.8 1.4
Chest pain or discomfort 1.3 1.9 3.6 1.9 0.2 -1.1 1.7
Had major operations 0.1 0.1 0.2 -0.2 0.3 -0.4 -0.2
Age at last live birth 0.2 0.2 0.6 0.6 -0.2 -0.0 0.8
Family relationship satisfaction 0.2 0.3 0.6 -0.5 -0.5 -0.8 0.2
Leg pain on walking 0.2 0.2 0.6 0.8 -0.3 -0.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 5.0 1.0 2.2 -1.7 -0.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 -0.7 0.1 -0.7 -0.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.6 -0.0 0.8 -0.2 -0.3
Medication: Aspirin 3.2 4.2 6.5 1.8 1.2 -2.5 2.4
Supplements: Vitamin C 0.0 0.0 0.1 0.2 0.2 0.2 -0.2
Knee pain experienced in last month 1.3 2.1 6.2 2.5 0.3 -0.3 1.4
Hypertension (Self-reported) 2.2 6.2 10.0 3.2 2.4 -2.3 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 4.5 -0.7 -0.9 2.1 0.6
Illnesses of father: Heart disease 3.4 4.8 8.9 2.3 0.7 -3.0 2.1
Illnesses of siblings: Diabetes 5.7 7.0 14.9 2.4 2.3 -3.9 1.5
Smoking status: Previous 1.5 2.2 3.5 -1.3 -1.6 0.9 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.3 -0.5 -0.4 1.1 -0.1
Whole body fat-free mass 0.1 0.8 1.5 0.5 1.2 -0.7 -1.1
Leg fat-free mass (right) 0.1 0.8 2.6 0.0 0.8 0.2 -1.6
Arm fat percentage (left) 0.1 0.4 0.9 0.8 0.9 -0.4 0.2
Average weekly red wine intake 1.8 2.7 5.1 -2.2 -1.3 1.0 -1.7
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.1 1.3 1.4 -0.8 1.1
Mood swings 0.2 0.4 0.8 -0.2 -0.9 -0.9 -0.3
Loneliness, isolation 0.3 0.4 1.0 1.0 -0.5 0.1 -0.5
Long-standing illness, disability or infirmity 0.6 0.9 2.0 1.3 -0.1 -1.4 0.1
Ever had bowel cancer screening 1.1 1.3 3.3 0.6 1.8 -1.3 0.1
Diabetes diagnosed by doctor 3.0 4.9 14.0 0.8 2.0 -3.7 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.8 1.4 0.4 -0.4 0.6
Friendships satisfaction 0.6 0.7 1.5 -0.5 1.2 -1.0 0.2
Qualifications: nursing, teaching 0.4 0.6 1.6 0.1 -0.7 1.3 -0.6
Commuting to job workplace: Walk 1.2 1.3 3.1 0.4 -1.8 0.7 1.2
Eye problems/disorders: Cataract 2.0 2.3 4.4 -1.3 -1.3 1.1 -2.1
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 4.2 1.9 2.0 -1.1 1.1
Medication for cholesterol 0.1 0.1 0.3 -0.2 -0.3 -0.6 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.1 1.0 -0.6 0.0 0.3
Back pain experienced in last month 0.3 0.4 1.3 0.6 -1.1 -0.0 0.2
Mineral and other dietary supplements 0.2 0.3 0.5 -0.2 0.7 -0.7 -0.3
Breast cancer (self-reported) 1.2 1.4 3.6 0.8 1.1 -1.9 0.4
Asthma (self-reported) 0.1 0.2 0.8 -0.9 -0.0 0.2 0.2
Osteoporosis (self-reported) 0.6 0.7 1.4 1.2 -0.9 -0.1 0.8
Osteoarthritis (self-reported) 0.2 0.3 1.0 -0.1 -1.0 0.1 -0.3
Medication: Aspirin 3.0 4.0 5.7 1.7 1.4 -2.4 2.3
Medication: Gliclazide 1.1 1.2 2.4 0.4 0.9 -1.2 1.6
Illnesses of father: None of the above (group 1) 3.9 4.8 10.1 -2.2 -0.9 3.2 -1.8
Smoking status: Current 0.4 0.6 2.4 0.4 -0.3 -1.5 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 17.5 37.0 50.7 -7.1 -6.2 5.8 -5.0
Whole body water mass 0.1 0.8 1.4 0.5 1.2 -0.6 -1.1
Leg predicted mass (right) 0.2 0.9 2.9 -0.1 0.7 0.2 -1.7
Arm fat mass (left) 0.1 0.6 1.0 0.9 1.0 -0.7 0.1
Number of self-reported non-cancer illnesses 0.5 0.9 2.3 1.5 -0.3 -1.1 0.2
Average weekly champagne plus white wine intake 0.3 0.5 1.3 0.5 0.5 1.1 0.2
Miserableness 0.3 0.6 1.6 -0.6 -1.3 -0.2 -0.5
Guilty feelings 0.4 0.6 1.1 0.6 -1.0 1.0 0.1
Wears glasses or contact lenses 0.5 0.5 1.5 0.1 0.5 -0.6 -1.2
Ever taken oral contraceptive pill 0.5 0.5 1.2 -0.4 -0.7 0.5 1.1
Hearing aid user 0.4 0.4 1.3 -0.2 1.1 0.4 -0.5
Mother’s age at death 1.8 2.2 3.5 1.9 1.7 -1.0 1.2
Financial situation satisfaction 0.2 0.3 0.6 -0.8 0.3 0.1 0.6
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 0.1 0.8 -0.7 -0.4
Commuting to job workplace: Public transport 0.2 0.3 0.9 -0.3 0.9 -0.1 -0.4
Eye problems/disorders: Glaucoma 0.9 1.1 1.9 -1.4 0.3 0.7 -1.4
Medication: Blood pressure 0.6 1.2 2.3 1.4 0.1 -0.6 1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.3 1.0 0.9 -1.1 -0.3
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.4 0.6 -0.5 0.3 0.0
High cholesterol (Self-reported) 2.0 3.5 3.9 2.0 1.6 -1.9 2.0
Medication: Bendroflumethiazide 1.4 2.1 3.6 1.9 0.9 -1.0 1.8
Medication: Paracetamol 2.8 4.4 9.2 3.0 -0.9 -1.9 2.0
Medication: Lisinopril 1.8 2.3 4.3 2.1 1.0 -1.6 1.2
Medication: Atorvastatin 1.7 2.1 3.8 1.9 0.9 -1.7 1.0
Illnesses of father: High blood pressure 1.6 1.9 4.7 0.9 1.0 -2.2 1.1
Alcohol drinker status: Never 0.4 0.5 1.5 0.3 0.7 0.3 1.2
Ever smoked 0.6 1.0 3.2 -0.2 -0.1 -0.9 -1.8
Basal metabolic rate 0.1 0.6 0.9 0.5 1.0 -0.6 -0.9
Leg fat percentage (left) 0.4 1.4 2.0 1.4 0.6 -1.2 1.3
Arm fat-free mass (left) 0.1 0.6 1.1 0.8 1.1 -0.8 -0.4
Number of operations (self-reported) 0.4 0.6 1.4 0.6 1.2 -0.7 -0.2
Average weekly beer plus cider intake 1.6 2.4 6.6 1.3 2.6 -1.1 -0.3
Irritability 0.5 0.8 1.6 -0.3 -0.4 -1.2 -1.2
Risk taking 1.5 2.1 2.4 -1.3 -1.5 1.4 -1.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 -0.0 0.3 -1.2 -0.3
Fractured/broken bones in last 5 years 2.1 2.7 6.4 -1.8 -0.6 0.9 -2.5
Age started oral contraceptive pill 0.2 0.2 0.4 -0.6 -0.4 -0.1 -0.6
Diastolic blood pressure, automated reading 1.3 3.9 7.2 2.7 1.2 -0.7 2.5
Ever depressed for a whole week 0.5 0.6 2.0 0.5 0.1 -1.4 0.5
Unable to work because of sickness or disability 0.2 0.3 0.7 0.4 0.4 -0.4 -0.9
Commuting to job workplace: Cycle 1.1 1.3 2.5 1.6 1.4 -0.8 0.4
Myopia 1.1 1.6 3.4 1.4 0.9 -0.4 1.9
Vascular/heart problems diagnosed by doctor 1.4 3.9 5.2 -2.3 -1.8 2.2 -1.4
Cholesterol lowering medication 0.8 1.1 2.0 0.8 0.9 -1.4 1.1
Medication: Omeprazole (e.g. Zanprol) 3.1 3.8 6.3 -2.5 -1.8 2.1 -1.1
Pain experienced in last month 0.9 1.6 4.6 -2.1 -0.4 0.9 -0.8
Supplements: Calcium 0.8 0.9 3.1 -0.3 -1.7 0.5 0.2
Basal cell carcinoma (self-reported) 2.1 2.5 4.1 -1.5 -0.2 2.0 -1.8
Heart attack/myocardial infarction (self-reported) 2.9 3.7 8.3 1.6 1.1 -2.9 1.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.9 -0.3 -0.9 -0.3 -0.6
Heart disease (siblings) 1.6 1.9 3.6 1.9 0.1 -1.4 1.5
Alcohol drinker status: Previous 2.3 2.6 5.9 -1.5 -1.5 2.4 -0.5
Pack years of smoking 0.9 1.3 3.2 1.8 0.2 -0.3 1.4
Impedance of whole body 0.6 3.0 4.7 -2.2 -2.1 1.6 -0.8
Leg fat mass (left) 0.2 0.9 1.4 1.2 0.9 -1.1 0.5
Arm predicted mass (left) 0.1 0.6 1.2 0.8 1.1 -0.8 -0.1