Hub : Genes

CDC123

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0644	0.0140	1.3e-10	0.039	0.038	0.037	0.044	0.040	1.2e-12	1.9e-12	3.8e-12	4.7e-14	5.2e-13
2	YFS	Blood	0.0756	0.0175	2.6e-10	0.031	0.044	0.059	0.048	0.050	1.7e-10	3.3e-14	9.6e-19	1.7e-15	5.1e-16
3	TCGA	Pheochromocytoma and Paraganglioma	0.2580	0.1090	2.9e-03	0.067	0.063	0.060	NA	0.065	1.2e-03	1.7e-03	2.2e-03	NA	1.4e-03
4	TCGA	Soft Tissue Sarcoma	0.0830	0.0480	9.3e-03	-0.003	0.034	0.002	NA	-0.002	5.7e-01	4.0e-03	2.4e-01	NA	4.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.5	-0.7	-1.0	1.2	-1.1
Bipolar Disorder or Schizophrenia	1.8	4.3	7.6	-1.2	-2.0	2.8	-2.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	-0.1	-1.3	-0.1	-0.3
Depression (Nagel 2018)	0.5	0.8	2.2	-0.2	-1.5	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.3	0.5	-0.9	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	2.4	0.2	-1.5	-0.1	0.4
Schizophrenia (2018)	1.7	3.5	6.6	-1.0	-1.9	2.6	-1.8
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.4	0.0	-0.4	-0.6
Worry (Nagel 2018)	0.4	0.9	1.5	0.7	-1.2	-0.7	1.0
Alzheimer’s Disease (in mother)	0.6	0.7	2.2	-0.5	0.2	1.5	-0.6
Alzheimer’s Disease (in father)	2.1	2.3	3.4	1.8	0.6	-1.6	1.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.7	-0.1	-0.3	0.4
Crohns Disease (2017)	0.3	0.8	2.0	1.4	0.8	-0.4	0.3
Irritable Bowel Disease (IBD)	0.4	0.9	1.9	1.1	1.4	0.8	-0.1
Ulcerative Colitis (UC)	0.7	1.2	3.1	0.3	1.2	1.8	-0.6
Major Depression (MDD)	3.4	4.1	7.1	-2.0	-2.7	1.6	-1.6
Reaction Time	0.1	0.2	0.3	0.5	-0.1	0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.6	0.7	-0.4	-0.2
Breast Cancer	0.3	0.8	1.2	0.7	1.0	-1.1	0.9
Ovarian Cancer	0.3	0.4	1.6	0.2	-0.2	1.3	-0.1
Prostate Cancer	1.4	1.9	5.3	-1.5	-2.3	0.0	0.5
Age at First Birth	0.2	0.4	0.8	0.9	-0.0	-0.4	0.7
Bipolar Disorder (2011)	2.1	2.0	4.9	-0.7	-1.6	2.2	0.5
Body Mass Index (BMI) (2010)	0.6	0.9	2.0	-1.4	-0.9	0.7	-0.4
Coronary Artery Disease (CAD)	2.1	2.5	5.3	0.3	1.9	-2.3	0.9
Crohns Disease (2012)	1.0	1.5	3.8	1.9	1.0	-1.0	0.6
Mean Putamen Volume	0.3	0.4	0.7	0.5	0.1	-0.8	-0.8
Fasting Glucose	4.2	5.0	10.0	1.8	2.0	-3.2	1.5
HbA1C	3.8	4.2	8.5	1.9	0.6	-2.0	2.9
HDL Cholesterol	0.3	0.5	1.7	-0.3	-0.3	-0.6	-1.3
LDL Cholesterol	0.4	0.6	1.4	-0.7	0.0	1.2	-0.5
Lupus	2.8	4.3	8.0	2.7	1.2	-0.5	2.8
Neuroticism (2016)	1.3	1.9	2.6	-1.1	-1.6	1.6	-1.1
Primary Biliary Cirrhosis	1.4	1.9	5.3	2.3	0.4	-1.2	0.9
Rheumatoid Arthritis	0.5	0.7	1.9	0.2	0.0	1.4	-0.9
Schizophrenia (2014)	2.6	5.7	7.8	-1.6	-2.8	2.7	-2.3
Triglycerides	0.3	0.5	1.0	0.3	0.7	-0.5	1.0
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.2	0.7	2.1	-1.5	1.2
Ulcerative Colitis	0.6	0.9	1.6	-0.3	0.8	1.3	-1.0
Blood Eosinophil Count	0.1	0.7	1.8	-0.0	-0.8	1.3	0.7
Blood Platelet Count	0.3	3.3	9.4	-0.9	-3.1	1.7	-0.1
Blood Red Count	0.1	1.1	2.1	-0.9	-1.4	0.7	-1.0
Blood White Count	0.1	0.8	1.8	-0.2	-0.8	0.8	-1.3
Heel T-Score	0.0	0.2	0.5	0.3	0.2	0.7	-0.0
BMI	0.1	0.8	2.1	1.5	0.3	-0.1	1.1
Height	0.7	14.4	32.9	-4.2	-1.8	1.9	-5.7
Waist Hip Ratio (WHR)	0.3	1.1	2.1	0.9	-1.4	0.0	1.3
Systolic Blood Pressure	3.6	18.2	24.5	5.0	3.5	-3.6	4.8
Smoking Status	0.6	1.4	2.4	-0.9	-1.4	-0.3	-1.6
Allergy or Eczema	0.3	0.7	1.1	-0.7	0.3	1.0	-1.1
Cardiovascular Disease	1.5	4.8	10.4	3.2	1.5	-1.8	1.8
Hypothyroidism (self reported)	0.3	0.7	1.8	-0.0	0.6	0.8	1.3
Respiratory disease	0.0	0.0	0.1	-0.0	-0.3	0.3	-0.1
Type 2 Diabetes (T2D) (2018)	6.1	11.4	31.5	2.1	2.4	-5.6	2.1
Lung FEV1/FVC ratio	49.4	250.4	334.9	-18.3	-15.0	15.5	-14.2
Lung FVC	8.2	41.7	52.8	-7.3	-5.3	6.4	-6.7
Neuroticism	0.6	1.5	3.8	1.4	-0.2	-2.0	0.7
Chronotype (morning person)	2.0	4.5	6.7	2.2	1.4	-2.2	2.6
Hair Pigment	0.0	1.1	2.8	0.6	1.0	-0.5	1.7
Tanning	0.1	1.3	3.4	-1.2	-0.7	0.2	-1.9
Hand grip strength (left)	0.1	0.4	1.1	1.1	0.4	-0.5	0.2
Number of treatments/medications taken	1.0	1.8	3.6	1.4	0.2	-1.3	1.9
Average weekly spirits intake	1.0	1.2	2.3	-1.5	-1.5	0.7	-0.2
Sensitivity / hurt feelings	0.2	0.4	0.7	0.5	-0.5	-0.9	0.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.5	1.6	-1.1	-0.0	1.1
Hearing difficulty/problems: Yes	1.7	2.6	4.8	2.2	1.3	-0.9	1.8
Relative age of first facial hair	0.1	0.2	0.4	0.2	-0.6	0.5	0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.7	0.8	-0.4	-0.3	1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	0.5	0.2	-0.8	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.0	0.4	0.4	-1.4	-0.1
Systolic blood pressure, automated reading	4.8	13.9	18.0	3.7	2.9	-3.9	4.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-1.6	-1.3	-0.3	0.4
Angina	2.9	3.8	7.8	2.2	1.3	-2.8	0.9
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.0	0.4	0.5	-0.0
Vitamin and mineral supplements	0.1	0.1	0.3	0.5	0.2	-0.5	-0.1
Supplements: Zinc	3.5	3.8	7.4	-1.7	-1.2	2.7	-1.8
Medication: Co-codamol	1.2	1.4	3.2	0.9	0.4	-1.8	1.1
Medication: Metformin	5.4	7.6	19.7	1.8	2.0	-4.4	1.9
Diabetes (father)	0.7	0.9	3.3	-0.1	0.5	-1.8	-0.2
Diabetes (mother)	12.8	16.4	30.8	4.0	2.8	-5.5	3.3
Severe depression (siblings)	0.8	0.9	2.3	1.5	-0.7	1.0	0.1
Pack years adult smoking proportion	1.2	1.9	4.3	2.1	0.2	-0.5	1.7
Impedance of leg (right)	0.2	1.2	2.6	-1.4	-1.6	0.3	0.5
Leg fat-free mass (left)	0.1	0.8	2.1	0.2	1.0	-0.2	-1.4
Trunk fat percentage	0.0	0.0	0.1	0.2	0.2	-0.1	0.2
Hand grip strength (right)	0.2	0.6	1.1	0.8	0.4	-0.8	-1.0
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.4	-0.4	-0.6	-0.5
Current tobacco smoking	0.4	0.7	2.4	0.0	-0.4	-1.6	-0.2
Average weekly fortified wine intake	1.6	1.9	6.7	0.9	0.2	-0.2	2.6
Maternal smoking around birth	0.0	0.0	0.1	0.3	0.1	0.2	0.3
Fed-up feelings	0.4	0.8	2.3	0.8	-0.2	-1.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.9	-1.0	-1.7	1.2	-0.9
Relative age voice broke	0.3	0.5	0.9	0.3	-0.6	0.9	-0.9
Taking other prescription medications	0.6	0.9	1.7	-0.2	-1.3	0.6	1.2
Age when periods started (menarche)	0.1	0.3	0.7	0.4	-0.1	-0.8	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	0.5	1.1	-0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.3	1.2	1.8	-1.3	0.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.5	1.9	1.1	-0.1	1.1
Qualifications: CSEs or equivalent	1.0	1.3	3.7	0.4	-0.3	-1.1	1.9
Serious illness, injury or assault to yourself	0.9	1.1	2.6	0.5	-1.6	-1.0	0.9
High blood pressure	1.9	5.3	8.1	2.8	2.2	-2.3	1.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.1	0.3	0.9	-0.3
Multivitamins +/- minerals	0.4	0.6	1.0	-0.2	-0.9	1.0	0.6
Stomach or abdominal pain in last month	1.0	1.3	2.6	1.4	-0.4	0.4	1.6
Supplements: Glucosamine	0.2	0.3	0.6	0.3	0.6	-0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.1	-1.2	0.8	-0.4
Medication: Atenolol	3.2	4.0	6.5	2.6	2.1	-1.4	1.7
Medication: Levothyroxine sodium	1.6	2.8	8.4	1.2	0.7	-0.9	2.9
Sitting height	0.7	5.3	13.0	-2.3	-1.0	1.4	-3.6
Chronic bronchitis/emphysema (father)	0.6	0.6	1.9	1.4	-0.2	0.5	0.7
High blood pressure (mother)	3.6	5.0	11.9	3.4	0.2	-1.2	2.6
Body mass index (BMI)	0.6	2.7	4.2	2.0	1.4	-1.4	1.6
Impedance of leg (left)	0.3	1.6	3.6	-1.4	-1.9	0.8	0.5
Leg predicted mass (left)	0.2	0.8	2.1	0.1	1.0	-0.2	-1.5
Trunk fat mass	0.0	0.1	0.2	0.3	0.5	-0.3	-0.2
Waist circumference	0.5	1.8	3.7	1.9	0.9	-0.8	1.4
Number of incorrect matches in round	1.4	2.3	4.2	-1.1	-2.0	2.0	0.1
Past tobacco smoking	0.5	0.8	2.2	0.3	1.0	0.3	1.5
Alcohol usually taken with meals	1.1	1.7	4.0	-2.0	-0.8	1.4	-0.6
Nervous feelings	0.9	1.8	5.1	-0.3	-1.3	-0.5	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.2	1.2	-1.5	-0.3	1.0
Hearing difficulty/problems with background noise	0.5	0.9	1.4	1.2	0.7	-1.0	0.8
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	-0.0	-1.2	0.8	-1.0
Had menopause	0.4	0.4	0.9	0.3	-1.0	-0.8	0.3
Had other major operations	0.3	0.4	1.0	-0.6	1.0	-0.3	-0.4
Forced vital capacity (FVC)	7.4	28.3	40.2	-5.5	-4.1	5.1	-6.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.7	1.3	1.9	-1.2	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.1	-1.1	-0.3	0.4
Qualifications: None of the above	0.3	0.6	1.6	-0.9	-1.2	0.4	0.1
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.1	-0.8	1.3	0.6
Mouth/teeth dental problems	1.4	2.1	4.3	-1.2	-1.3	2.1	-1.0
Heart attack	2.9	3.8	9.4	1.4	1.3	-3.1	1.3
Allergy	0.0	0.1	0.2	0.4	0.2	-0.4	-0.3
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.5	-0.4	-0.7
Diabetes (self-reported)	2.6	4.0	11.4	0.4	1.6	-3.4	1.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	-0.3	0.1	0.2	-1.2
Medication: Ramipril	6.5	8.3	11.5	3.4	1.8	-3.4	2.7
Medication: Simvastatin	1.7	2.5	4.6	1.3	1.7	-2.2	1.0
Fluid intelligence score	0.2	0.5	1.3	-0.6	0.1	0.6	-1.2
Illnesses of siblings	2.4	3.4	5.0	-2.2	-0.9	2.1	-1.9
Neuroticism score	0.5	1.0	1.5	0.9	-1.0	-1.2	0.7
Weight	0.1	0.4	0.7	0.7	0.9	-0.6	-0.4
Impedance of arm (right)	0.9	4.0	6.5	-2.5	-1.0	2.0	-2.2
Arm fat percentage (right)	0.2	0.7	1.8	0.8	1.3	-0.4	0.3
Trunk fat-free mass	0.1	0.8	1.3	0.5	1.2	-0.8	-1.0
Hip circumference	0.2	0.7	1.9	0.8	1.4	-0.5	-0.1
Time employed in main current job	0.3	0.3	0.4	0.7	0.5	-0.5	0.5
Alcohol intake versus 10 years previously	2.5	3.7	5.9	1.9	2.3	-2.4	0.0
Father’s age at death	0.2	0.2	0.8	-0.9	-0.3	-0.3	-0.2
Worrier / anxious feelings	0.2	0.4	1.1	-0.3	-1.0	-0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.2	1.5	-1.1	-1.1	-0.1
Falls in the last year	0.2	0.3	0.6	-0.2	-0.7	0.8	-0.2
Hair/balding pattern: Pattern 3	0.6	0.9	3.1	-0.2	-0.1	0.5	1.8
Number of live births	0.2	0.3	1.0	-0.6	-0.0	1.0	0.1
Forced expiratory volume in 1-second (FEV1)	22.2	75.0	93.1	-9.6	-7.4	8.7	-8.7
Pulse rate	1.9	3.1	6.5	-1.5	-1.6	2.6	-1.1
Happiness	0.7	0.9	1.8	-1.2	-1.3	0.3	0.5
Noisy workplace	0.5	0.6	1.2	0.5	-0.6	-0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.2	1.1	0.9	0.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	-0.8	-0.5	0.1	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.4	2.7	0.6	1.0	-1.6	1.3
Asthma	0.3	0.5	1.6	-1.2	-0.3	0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.3	0.3	0.3	-0.4
Medication: Cholesterol lowering	2.0	3.2	6.9	1.7	1.4	-2.6	1.0
Depression (self-reported)	0.4	0.5	1.4	-0.2	-0.6	0.1	-1.2
Medication: Lansoprazole	0.6	0.6	1.8	-0.4	-1.3	0.7	0.2
Prospective memory result	0.2	0.2	0.4	-0.7	0.5	0.3	-0.3
Lung cancer (father)	1.6	1.9	6.3	0.4	-0.4	2.5	1.0
Illnesses of mother	4.1	5.1	12.7	-3.6	-0.5	1.5	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	21.6	69.0	81.6	-9.0	-7.4	8.6	-8.1
Pulse wave Arterial Stiffness index	1.3	1.5	2.3	1.5	0.3	1.1	1.5
Impedance of arm (left)	1.1	5.3	7.6	-2.8	-2.1	2.1	-2.2
Arm fat mass (right)	0.1	0.5	1.0	0.8	1.0	-0.6	0.2
Trunk predicted mass	0.1	0.8	1.4	0.6	1.2	-0.8	-1.0
Standing height	0.7	7.2	16.2	-2.9	-1.3	1.6	-4.0
Length of working week for main job	0.1	0.1	0.2	0.1	-0.4	0.2	-0.3
Exposure to tobacco smoke at home	1.3	1.4	1.9	1.0	1.4	-1.4	-1.0
Breastfed as a baby	0.2	0.3	0.6	0.0	0.4	-0.6	-0.7
Tense / ‘highly strung’	0.2	0.3	1.0	1.0	-0.3	-0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.9	-0.1	-1.7	0.8	-0.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	-1.2	-0.3	-0.1	-1.4
Birth weight of first child	0.4	0.7	2.6	0.3	1.6	0.1	-0.2
Peak expiratory flow (PEF)	18.8	43.6	58.1	-7.6	-5.0	6.5	-7.0
Pulse wave reflection index	2.4	2.9	5.7	2.4	1.0	-0.8	2.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.6	1.4	0.5	-1.0	1.6
Loud music exposure frequency	1.6	1.8	2.8	0.2	-1.7	1.2	1.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	-0.1	-0.4	1.2	-0.1
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	6.0	2.5	0.7	-1.7	1.6
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.6	-1.1	-0.1	-0.7
Medication: Paracetamol	1.7	2.8	6.8	2.6	-0.9	-1.5	1.3
Headache pain in last month	0.7	1.2	3.9	0.1	-0.9	2.0	-0.3
Medication for cholesterol, blood pressure or diabetes	3.6	6.0	12.1	-2.5	-1.8	3.5	-1.7
Glaucoma (self-reported)	0.8	1.0	1.6	-1.3	-0.3	1.0	-1.1
Gout (self-reported)	0.0	0.1	0.1	0.2	0.2	-0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.1	-0.1	0.7	0.1	2.0
Medication: Amlodipine	0.4	0.6	2.3	0.1	0.0	-1.5	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.3	0.3	0.1	0.7
Birth weight	1.8	3.8	8.2	2.2	2.9	-1.1	1.1
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.7	0.7	-1.3	1.1	0.3
High blood pressure (siblings)	2.0	2.8	6.1	2.5	-0.3	-0.4	2.2
Forced vital capacity (FVC), Best measure	7.0	25.5	34.7	-5.2	-4.0	4.9	-5.9
Body fat percentage	0.1	0.5	0.7	0.8	0.7	-0.7	0.6
Leg fat percentage (right)	0.5	1.8	3.0	1.4	0.9	-1.7	1.2
Arm fat-free mass (right)	0.1	0.5	0.8	0.7	0.6	-0.9	-0.6
Exposure to tobacco smoke outside home	0.7	0.9	2.3	1.5	0.4	-0.5	-0.9
Comparative body size at age 10	1.9	5.4	8.3	2.9	2.1	-1.9	2.3
Number of full brothers	0.4	0.4	1.3	0.3	0.6	-0.1	-1.2
Worry too long after embarrassment	0.3	0.5	1.2	1.1	0.1	-0.3	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.1	-1.0	-1.3	0.7	-1.8
Wheeze or whistling in the chest in last year	1.7	3.1	4.7	2.2	1.4	-1.9	1.3
Number of children fathered	1.3	1.5	3.5	-1.9	-1.1	1.0	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.8	0.0	0.8	-1.4	-1.0
Age at first live birth	0.2	0.3	0.5	0.7	0.4	0.3	0.7
Pulse wave peak to peak time	1.4	1.7	3.0	-1.7	-0.4	-1.0	-1.6
Health satisfaction	1.6	2.1	3.7	1.9	-0.3	-1.5	1.5
Shortness of breath walking on level ground	0.6	0.8	2.3	0.2	-1.5	0.7	-0.5
Qualifications: College or University degree	0.0	0.2	0.3	-0.1	-0.6	0.5	-0.1
Eye problems/disorders: None of the above	1.2	1.3	3.1	1.3	0.6	-0.3	1.8
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.2	0.4	1.8	-1.6	-0.7
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.2	0.2	-0.4	-0.5
Medication for pain relief, constipation, heartburn	1.4	2.4	4.4	-2.0	0.1	1.2	-2.1
Neck or shoulder pain in last month	0.6	0.8	2.5	0.3	0.3	-1.6	0.8
Medication: Blood pressure	3.6	6.3	9.7	2.8	2.2	-3.1	1.7
Angina (self-reported)	4.0	5.3	9.6	2.7	1.4	-3.1	1.5
Migraine (self-reported)	0.5	0.6	1.2	-0.2	-1.1	0.1	-1.1
Medication: Ibuprofen	0.2	0.3	0.5	-0.0	-0.3	0.7	-0.6
Medication: Allopurinol	0.5	0.7	1.4	0.7	1.2	-0.8	0.4
Medication: Omeprazole	2.0	2.4	3.8	-1.9	-1.2	1.9	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.3	0.8	0.2	-0.1
Mean time to correctly identify matches	0.2	0.5	1.2	1.1	0.6	-0.3	-0.3
Heart disease (mother)	0.1	0.1	0.4	0.1	0.3	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	0.7	1.2	-0.4	1.8
Whole body fat mass	0.1	0.4	0.6	0.7	0.8	-0.7	-0.0
Leg fat mass (right)	0.3	1.2	2.1	1.2	1.1	-1.4	0.4
Arm predicted mass (right)	0.1	0.4	0.6	0.8	0.4	-0.7	-0.5
Pulse rate, automated reading	1.9	6.0	9.8	-3.0	-1.8	1.4	-3.1
Alcohol intake frequency.	0.5	1.1	2.7	-0.4	-1.2	1.6	0.4
Comparative height size at age 10	1.3	7.0	16.2	-3.0	-0.0	1.8	-4.0
Number of full sisters	0.7	0.9	2.0	1.4	-0.6	-0.9	0.6
Suffer from ‘nerves’	0.5	0.9	2.5	0.9	-1.6	0.1	0.4
Overall health rating	1.7	3.6	7.0	2.6	1.4	-1.8	1.4
Chest pain or discomfort	1.3	1.9	3.6	1.9	0.2	-1.1	1.7
Had major operations	0.1	0.1	0.2	-0.2	0.3	-0.4	-0.2
Age at last live birth	0.2	0.2	0.6	0.6	-0.2	-0.0	0.8
Family relationship satisfaction	0.2	0.3	0.6	-0.5	-0.5	-0.8	0.2
Leg pain on walking	0.2	0.2	0.6	0.8	-0.3	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	5.0	1.0	2.2	-1.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.7	0.1	-0.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	-0.0	0.8	-0.2	-0.3
Medication: Aspirin	3.2	4.2	6.5	1.8	1.2	-2.5	2.4
Supplements: Vitamin C	0.0	0.0	0.1	0.2	0.2	0.2	-0.2
Knee pain experienced in last month	1.3	2.1	6.2	2.5	0.3	-0.3	1.4
Hypertension (Self-reported)	2.2	6.2	10.0	3.2	2.4	-2.3	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.5	-0.7	-0.9	2.1	0.6
Illnesses of father: Heart disease	3.4	4.8	8.9	2.3	0.7	-3.0	2.1
Illnesses of siblings: Diabetes	5.7	7.0	14.9	2.4	2.3	-3.9	1.5
Smoking status: Previous	1.5	2.2	3.5	-1.3	-1.6	0.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.5	-0.4	1.1	-0.1
Whole body fat-free mass	0.1	0.8	1.5	0.5	1.2	-0.7	-1.1
Leg fat-free mass (right)	0.1	0.8	2.6	0.0	0.8	0.2	-1.6
Arm fat percentage (left)	0.1	0.4	0.9	0.8	0.9	-0.4	0.2
Average weekly red wine intake	1.8	2.7	5.1	-2.2	-1.3	1.0	-1.7
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.1	1.3	1.4	-0.8	1.1
Mood swings	0.2	0.4	0.8	-0.2	-0.9	-0.9	-0.3
Loneliness, isolation	0.3	0.4	1.0	1.0	-0.5	0.1	-0.5
Long-standing illness, disability or infirmity	0.6	0.9	2.0	1.3	-0.1	-1.4	0.1
Ever had bowel cancer screening	1.1	1.3	3.3	0.6	1.8	-1.3	0.1
Diabetes diagnosed by doctor	3.0	4.9	14.0	0.8	2.0	-3.7	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.8	1.4	0.4	-0.4	0.6
Friendships satisfaction	0.6	0.7	1.5	-0.5	1.2	-1.0	0.2
Qualifications: nursing, teaching	0.4	0.6	1.6	0.1	-0.7	1.3	-0.6
Commuting to job workplace: Walk	1.2	1.3	3.1	0.4	-1.8	0.7	1.2
Eye problems/disorders: Cataract	2.0	2.3	4.4	-1.3	-1.3	1.1	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	4.2	1.9	2.0	-1.1	1.1
Medication for cholesterol	0.1	0.1	0.3	-0.2	-0.3	-0.6	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	1.0	-0.6	0.0	0.3
Back pain experienced in last month	0.3	0.4	1.3	0.6	-1.1	-0.0	0.2
Mineral and other dietary supplements	0.2	0.3	0.5	-0.2	0.7	-0.7	-0.3
Breast cancer (self-reported)	1.2	1.4	3.6	0.8	1.1	-1.9	0.4
Asthma (self-reported)	0.1	0.2	0.8	-0.9	-0.0	0.2	0.2
Osteoporosis (self-reported)	0.6	0.7	1.4	1.2	-0.9	-0.1	0.8
Osteoarthritis (self-reported)	0.2	0.3	1.0	-0.1	-1.0	0.1	-0.3
Medication: Aspirin	3.0	4.0	5.7	1.7	1.4	-2.4	2.3
Medication: Gliclazide	1.1	1.2	2.4	0.4	0.9	-1.2	1.6
Illnesses of father: None of the above (group 1)	3.9	4.8	10.1	-2.2	-0.9	3.2	-1.8
Smoking status: Current	0.4	0.6	2.4	0.4	-0.3	-1.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	17.5	37.0	50.7	-7.1	-6.2	5.8	-5.0
Whole body water mass	0.1	0.8	1.4	0.5	1.2	-0.6	-1.1
Leg predicted mass (right)	0.2	0.9	2.9	-0.1	0.7	0.2	-1.7
Arm fat mass (left)	0.1	0.6	1.0	0.9	1.0	-0.7	0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	1.5	-0.3	-1.1	0.2
Average weekly champagne plus white wine intake	0.3	0.5	1.3	0.5	0.5	1.1	0.2
Miserableness	0.3	0.6	1.6	-0.6	-1.3	-0.2	-0.5
Guilty feelings	0.4	0.6	1.1	0.6	-1.0	1.0	0.1
Wears glasses or contact lenses	0.5	0.5	1.5	0.1	0.5	-0.6	-1.2
Ever taken oral contraceptive pill	0.5	0.5	1.2	-0.4	-0.7	0.5	1.1
Hearing aid user	0.4	0.4	1.3	-0.2	1.1	0.4	-0.5
Mother’s age at death	1.8	2.2	3.5	1.9	1.7	-1.0	1.2
Financial situation satisfaction	0.2	0.3	0.6	-0.8	0.3	0.1	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.1	0.8	-0.7	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.9	-0.3	0.9	-0.1	-0.4
Eye problems/disorders: Glaucoma	0.9	1.1	1.9	-1.4	0.3	0.7	-1.4
Medication: Blood pressure	0.6	1.2	2.3	1.4	0.1	-0.6	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.3	1.0	0.9	-1.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.6	-0.5	0.3	0.0
High cholesterol (Self-reported)	2.0	3.5	3.9	2.0	1.6	-1.9	2.0
Medication: Bendroflumethiazide	1.4	2.1	3.6	1.9	0.9	-1.0	1.8
Medication: Paracetamol	2.8	4.4	9.2	3.0	-0.9	-1.9	2.0
Medication: Lisinopril	1.8	2.3	4.3	2.1	1.0	-1.6	1.2
Medication: Atorvastatin	1.7	2.1	3.8	1.9	0.9	-1.7	1.0
Illnesses of father: High blood pressure	1.6	1.9	4.7	0.9	1.0	-2.2	1.1
Alcohol drinker status: Never	0.4	0.5	1.5	0.3	0.7	0.3	1.2
Ever smoked	0.6	1.0	3.2	-0.2	-0.1	-0.9	-1.8
Basal metabolic rate	0.1	0.6	0.9	0.5	1.0	-0.6	-0.9
Leg fat percentage (left)	0.4	1.4	2.0	1.4	0.6	-1.2	1.3
Arm fat-free mass (left)	0.1	0.6	1.1	0.8	1.1	-0.8	-0.4
Number of operations (self-reported)	0.4	0.6	1.4	0.6	1.2	-0.7	-0.2
Average weekly beer plus cider intake	1.6	2.4	6.6	1.3	2.6	-1.1	-0.3
Irritability	0.5	0.8	1.6	-0.3	-0.4	-1.2	-1.2
Risk taking	1.5	2.1	2.4	-1.3	-1.5	1.4	-1.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	-0.0	0.3	-1.2	-0.3
Fractured/broken bones in last 5 years	2.1	2.7	6.4	-1.8	-0.6	0.9	-2.5
Age started oral contraceptive pill	0.2	0.2	0.4	-0.6	-0.4	-0.1	-0.6
Diastolic blood pressure, automated reading	1.3	3.9	7.2	2.7	1.2	-0.7	2.5
Ever depressed for a whole week	0.5	0.6	2.0	0.5	0.1	-1.4	0.5
Unable to work because of sickness or disability	0.2	0.3	0.7	0.4	0.4	-0.4	-0.9
Commuting to job workplace: Cycle	1.1	1.3	2.5	1.6	1.4	-0.8	0.4
Myopia	1.1	1.6	3.4	1.4	0.9	-0.4	1.9
Vascular/heart problems diagnosed by doctor	1.4	3.9	5.2	-2.3	-1.8	2.2	-1.4
Cholesterol lowering medication	0.8	1.1	2.0	0.8	0.9	-1.4	1.1
Medication: Omeprazole (e.g. Zanprol)	3.1	3.8	6.3	-2.5	-1.8	2.1	-1.1
Pain experienced in last month	0.9	1.6	4.6	-2.1	-0.4	0.9	-0.8
Supplements: Calcium	0.8	0.9	3.1	-0.3	-1.7	0.5	0.2
Basal cell carcinoma (self-reported)	2.1	2.5	4.1	-1.5	-0.2	2.0	-1.8
Heart attack/myocardial infarction (self-reported)	2.9	3.7	8.3	1.6	1.1	-2.9	1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.3	-0.9	-0.3	-0.6
Heart disease (siblings)	1.6	1.9	3.6	1.9	0.1	-1.4	1.5
Alcohol drinker status: Previous	2.3	2.6	5.9	-1.5	-1.5	2.4	-0.5
Pack years of smoking	0.9	1.3	3.2	1.8	0.2	-0.3	1.4
Impedance of whole body	0.6	3.0	4.7	-2.2	-2.1	1.6	-0.8
Leg fat mass (left)	0.2	0.9	1.4	1.2	0.9	-1.1	0.5
Arm predicted mass (left)	0.1	0.6	1.2	0.8	1.1	-0.8	-0.1