[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr10:63,856,856-66,034,105

Best TWAS P=9.42e-20 · Best GWAS P=6.55e-16 conditioned to 0.000111

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Skin Sun Exposed Lower leg	NRBF2	0.06	0.01	lasso	3	0.00	4.0e-01	-6.2	9.1	9.4e-20	-0.53	0.06	0.32	TRUE
8	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	-7.7	8.2	3.5e-16	-0.83	0.08	0.92	FALSE
5	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	-7.7	7.9	3.8e-15	-0.87	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	-7.5	7.8	6.5e-15	-0.87	0.00	1.00	FALSE
3	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	-7.4	7.8	9.1e-15	-0.88	0.05	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	-7.4	-7.7	1.6e-14	0.88	0.07	0.93	FALSE
19	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	-7.5	7.6	4.0e-14	-0.80	0.02	0.60	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	-7.4	7.5	5.6e-14	-0.89	0.19	0.81	FALSE
12	GTEx	Thyroid	NRBF2	0.11	0.05	lasso	3	0.07	2.5e-06	4.0	7.4	1.1e-13	-0.66	0.10	0.88	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	-7.4	7.4	1.1e-13	-0.90	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	-7.4	7.4	1.2e-13	-0.89	0.00	1.00	FALSE
2	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	7.6	7.4	1.5e-13	-0.87	0.05	0.94	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	-7.5	7.3	2.0e-13	-0.89	0.00	1.00	FALSE
11	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	-7.7	7.3	3.7e-13	-0.89	0.08	0.90	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	-7.5	7.2	4.3e-13	-0.89	0.00	1.00	FALSE
4	GTEx	Cells Transformed fibroblasts	JMJD1C	0.09	0.01	enet	18	0.07	8.6e-06	6.7	7.1	9.9e-13	-0.50	0.18	0.56	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBF2	0.17	0.09	enet	10	0.13	1.1e-04	-7.4	7.1	1.4e-12	-0.80	0.01	0.95	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	-7.5	7.0	2.2e-12	-0.87	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	-7.5	7.0	2.6e-12	-0.84	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	-7.4	6.6	4.3e-11	-0.76	0.02	0.82	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	3.5	-6.4	1.6e-10	0.72	0.05	0.94	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	-7.4	6.3	3.0e-10	-0.78	0.00	0.90	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBF2	0.07	0.04	blup	42	0.02	7.3e-03	-7.5	6.2	4.2e-10	-0.77	0.00	0.99	FALSE
10	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	5.0	6.2	5.6e-10	-0.67	0.06	0.56	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	3.9	6.2	7.3e-10	-0.79	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC84989	0.10	0.05	blup	19	0.04	7.7e-03	4.3	6.1	1.2e-09	-0.62	0.01	0.36	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBF2	0.13	0.10	enet	11	0.09	4.9e-06	-7.4	6.1	1.3e-09	-0.70	0.00	0.99	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	-5.9	6.0	1.6e-09	-0.05	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	3.3	5.9	3.1e-09	-0.77	0.07	0.89	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	ADO	0.06	0.04	lasso	2	0.06	3.1e-08	-5.9	5.9	3.4e-09	-0.10	0.99	0.00	FALSE
6	GTEx	Esophagus Muscularis	NRBF2	0.10	0.03	enet	22	0.03	3.8e-03	-6.4	5.7	9.2e-09	-0.71	0.03	0.93	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	ADO	0.14	0.05	blup	53	0.05	3.8e-06	-6.2	5.7	1.4e-08	-0.07	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADO	0.06	0.04	blup	55	0.01	1.4e-01	-5.9	5.5	3.7e-08	-0.07	0.01	0.81	FALSE
7	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	-5.9	5.4	5.7e-08	-0.02	0.94	0.01	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	4.8	-5.4	7.2e-08	0.67	1.00	0.00	FALSE