[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr10:74,173,864-79,018,276

Best TWAS P=2.65e-16 · Best GWAS P=3.21e-21 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Brain Cortex	C10orf11	0.32	0.15	lasso	8	0.21	1.4e-06	7.7	-8.2	2.7e-16	0.77	0.35	0.60	TRUE
23	GTEx	Cells Transformed fibroblasts	CAMK2G	0.06	0.04	enet	10	0.06	2.2e-05	5.4	6.7	2.8e-11	-0.03	0.46	0.35	TRUE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC24C	0.04	0.02	blup	29	0.03	2.6e-06	5.2	6.5	5.8e-11	-0.02	0.01	0.98	TRUE
56	GTEx	Thyroid	ADK	0.10	0.05	lasso	3	0.05	1.6e-04	6.4	-6.4	1.5e-10	0.07	0.62	0.07	TRUE
30	GTEx	Esophagus Muscularis	VCL	0.05	0.00	lasso	3	0.00	6.8e-01	6.4	6.4	1.7e-10	-0.06	0.08	0.24	TRUE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NUDT13	0.16	0.07	enet	9	0.06	1.8e-03	-5.4	6.3	2.2e-10	0.02	0.02	0.89	TRUE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	ADK	0.05	0.06	enet	16	0.07	7.3e-09	6.4	-6.3	3.0e-10	0.06	0.06	0.94	TRUE
57	METSIM	Adipose	TTC18	0.04	0.02	blup	253	0.04	4.3e-07	-5.5	6.2	6.8e-10	-0.04	1.00	0.00	TRUE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	SEC24C	0.02	0.01	enet	4	0.01	8.5e-03	-4.8	6.1	8.8e-10	0.00	0.04	0.33	TRUE
31	GTEx	Esophagus Muscularis	FAM149B1	0.23	0.00	lasso	10	0.00	2.7e-01	-5.3	-6.1	1.4e-09	0.03	0.03	0.25	TRUE
55	GTEx	Thyroid	C10orf11	0.38	0.21	lasso	9	0.25	6.7e-19	-4.9	5.3	9.6e-08	0.01	1.00	0.00	TRUE
59	YFS	Blood	CAMK2G	0.01	0.00	blup	239	0.00	5.7e-02	4.1	-5.3	9.6e-08	0.09	0.26	0.01	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ADK	0.03	0.03	lasso	3	0.04	2.6e-05	6.2	5.3	1.4e-07	-0.09	0.68	0.15	TRUE
20	GTEx	Breast Mammary Tissue (Male)	FAM149B1	0.21	0.11	lasso	12	0.09	3.3e-03	-5.5	-5.2	1.6e-07	0.04	0.06	0.61	TRUE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TTC18	0.43	0.07	lasso	12	0.07	9.0e-04	-5.2	5.2	2.2e-07	-0.03	0.04	0.91	TRUE
37	GTEx	Muscle Skeletal	C10orf11	0.11	0.13	lasso	3	0.12	5.1e-12	7.7	-8.0	1.4e-15	0.73	1.00	0.00	FALSE
16	GTEx	Brain Frontal Cortex BA9	C10orf11	0.33	0.18	enet	11	0.19	9.3e-06	7.5	-7.8	5.4e-15	0.70	0.50	0.33	FALSE
11	GTEx	Brain Caudate basal ganglia	C10orf11	0.35	0.27	lasso	4	0.25	9.8e-08	7.5	-7.6	2.7e-14	0.69	0.71	0.23	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	C10orf11	0.20	0.23	lasso	4	0.23	1.1e-29	7.7	-7.2	7.4e-13	0.69	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	NDST2	0.03	0.02	blup	37	0.02	3.3e-03	-7.4	-6.6	4.4e-11	0.00	0.03	0.90	FALSE
34	GTEx	Lung	ADK	0.15	0.17	lasso	5	0.17	4.8e-13	6.3	-6.4	1.7e-10	0.08	0.92	0.08	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	ADK	0.10	0.16	lasso	6	0.15	3.7e-14	6.2	-6.3	3.9e-10	0.07	0.04	0.96	FALSE
39	GTEx	Nerve Tibial	FAM149B1	0.06	0.03	lasso	3	0.02	7.6e-03	-5.4	-6.2	7.6e-10	0.01	0.07	0.76	FALSE
53	GTEx	Testis	RP11-152N13.5	0.31	0.04	lasso	12	0.06	8.2e-04	3.0	-6.0	1.5e-09	0.01	0.05	0.77	FALSE
52	GTEx	Testis	MRPS16	0.14	0.06	enet	38	0.04	1.1e-02	-5.2	5.9	3.1e-09	-0.03	0.08	0.75	FALSE
43	GTEx	Prostate	RP11-574K11.5	0.29	0.02	enet	43	0.00	2.4e-01	4.5	-5.8	5.1e-09	0.03	0.04	0.08	FALSE
28	GTEx	Esophagus Mucosa	TTC18	0.15	0.13	enet	10	0.14	2.1e-09	-4.3	5.8	6.3e-09	-0.03	1.00	0.00	FALSE
60	YFS	Blood	NDST2	0.10	0.09	lasso	14	0.10	5.0e-30	5.5	-5.8	8.3e-09	0.03	1.00	0.00	FALSE
48	GTEx	Spleen	MRPS16	0.50	-0.01	lasso	6	0.02	1.1e-01	3.0	5.7	1.4e-08	-0.01	0.02	0.09	FALSE
26	GTEx	Colon Transverse	NUDT13	0.43	0.29	enet	30	0.32	8.1e-16	-5.5	5.6	2.5e-08	-0.03	0.03	0.97	FALSE
36	GTEx	Muscle Skeletal	FAM149B1	0.12	0.05	lasso	3	0.06	2.4e-06	-5.4	-5.6	2.5e-08	0.04	0.07	0.93	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TTC18	0.07	0.04	enet	34	0.06	4.3e-08	-5.3	5.6	2.7e-08	-0.02	1.00	0.00	FALSE
50	GTEx	Stomach	RP11-152N13.16	0.08	0.02	lasso	7	0.02	4.3e-02	-5.2	5.5	2.8e-08	-0.03	0.08	0.85	FALSE
7	GTEx	Adipose Visceral Omentum	FAM149B1	0.15	0.11	lasso	6	0.11	3.2e-06	-5.5	-5.5	2.9e-08	0.03	0.07	0.92	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC24C	0.07	0.07	blup	29	0.07	9.4e-05	-4.9	5.5	3.0e-08	0.00	0.09	0.70	FALSE
40	GTEx	Nerve Tibial	USP54	0.14	0.06	lasso	4	0.05	9.5e-05	-4.4	5.5	3.3e-08	-0.05	0.72	0.08	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	NUDT13	0.34	0.29	lasso	14	0.29	5.8e-10	-5.5	5.5	3.5e-08	-0.04	0.07	0.93	FALSE
47	GTEx	Spleen	NUDT13	0.21	0.22	lasso	15	0.24	1.0e-06	-5.5	5.5	3.7e-08	-0.04	0.07	0.92	FALSE
10	GTEx	Artery Aorta	NUDT13	0.28	0.34	lasso	7	0.34	8.8e-20	-5.5	5.5	3.8e-08	-0.04	0.03	0.97	FALSE
54	GTEx	Thyroid	FAM149B1	0.04	0.03	lasso	3	0.03	4.2e-03	-5.2	-5.5	3.8e-08	0.03	0.09	0.88	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NUDT13	0.29	0.29	lasso	4	0.30	3.5e-11	-5.5	5.5	4.0e-08	-0.03	0.01	0.99	FALSE
19	GTEx	Breast Mammary Tissue	NUDT13	0.23	0.25	enet	43	0.26	7.7e-14	-5.2	5.5	4.4e-08	-0.03	0.11	0.89	FALSE
45	GTEx	Skin Sun Exposed Lower leg	FAM149B1	0.03	0.03	lasso	8	0.02	1.1e-02	-5.4	-5.5	4.9e-08	0.03	0.06	0.83	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	NUDT13	0.19	0.05	lasso	3	0.07	8.6e-05	-5.5	5.5	5.1e-08	-0.03	0.02	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM149B1	0.03	0.03	blup	222	0.03	4.0e-05	-5.3	-5.4	5.4e-08	0.02	0.12	0.88	FALSE
51	GTEx	Testis	NUDT13	0.15	0.26	lasso	4	0.26	1.1e-11	-5.2	5.4	5.7e-08	-0.03	0.08	0.92	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	NUDT13	0.22	0.28	lasso	1	0.25	2.0e-24	-5.4	5.4	5.7e-08	-0.03	0.01	0.99	FALSE
13	GTEx	Brain Cerebellar Hemisphere	DNAJC9	0.16	0.07	lasso	5	0.08	3.8e-03	-5.5	-5.4	6.6e-08	0.03	0.07	0.63	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM149B1	0.02	0.01	blup	46	0.02	3.6e-03	-5.4	-5.4	6.6e-08	0.02	0.02	0.73	FALSE
9	GTEx	Artery Aorta	TTC18	0.15	0.12	enet	12	0.14	5.0e-08	-4.4	5.4	6.9e-08	-0.03	0.94	0.04	FALSE
24	GTEx	Colon Sigmoid	TTC18	0.09	0.06	lasso	14	0.07	1.6e-03	-5.3	5.4	7.2e-08	-0.02	0.48	0.17	FALSE
25	GTEx	Colon Sigmoid	NUDT13	0.23	0.32	lasso	21	0.32	4.1e-12	-5.2	5.4	7.8e-08	-0.04	0.10	0.90	FALSE
41	GTEx	Ovary	NUDT13	0.26	0.08	lasso	5	0.15	1.5e-04	-5.5	5.4	8.0e-08	-0.04	0.07	0.89	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NUDT13	0.23	0.12	lasso	2	0.11	1.0e-05	-5.4	5.4	8.0e-08	-0.03	0.01	0.98	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUDT13	0.17	0.25	blup	34	0.26	3.3e-29	-5.4	5.3	8.7e-08	-0.02	0.02	0.98	FALSE
18	GTEx	Breast Mammary Tissue	FAM149B1	0.16	0.14	lasso	10	0.18	1.6e-09	-5.5	-5.3	8.9e-08	0.04	0.09	0.91	FALSE
14	GTEx	Brain Cerebellum	RP11-152N13.5	0.09	0.07	lasso	17	0.03	4.1e-02	-5.3	5.3	9.3e-08	-0.04	0.07	0.66	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	NUDT13	0.18	0.16	lasso	12	0.19	9.2e-11	-5.5	5.3	9.3e-08	-0.03	0.04	0.96	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM149B1	0.09	0.08	blup	45	0.05	5.2e-04	-5.3	-5.3	9.3e-08	0.02	0.03	0.94	FALSE
38	GTEx	Muscle Skeletal	NUDT13	0.04	0.04	lasso	5	0.02	3.3e-03	-5.2	5.3	9.4e-08	-0.03	0.09	0.90	FALSE
8	GTEx	Artery Aorta	ECD	0.06	0.06	lasso	5	0.05	8.5e-04	-5.5	5.3	1.0e-07	-0.04	0.06	0.92	FALSE
32	GTEx	Esophagus Muscularis	RP11-152N13.5	0.05	0.00	lasso	9	0.00	2.4e-01	-5.3	5.3	1.0e-07	-0.03	0.06	0.49	FALSE
33	GTEx	Lung	FAM149B1	0.04	0.03	lasso	7	0.03	2.2e-03	-5.3	-5.3	1.0e-07	0.04	0.10	0.82	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	FAM149B1	0.32	0.11	lasso	1	0.10	3.3e-10	-5.3	-5.3	1.0e-07	0.03	0.02	0.98	FALSE
49	GTEx	Stomach	FAM149B1	0.12	0.08	lasso	3	0.05	1.3e-03	-5.2	-5.3	1.1e-07	0.03	0.09	0.90	FALSE
29	GTEx	Esophagus Mucosa	NUDT13	0.27	0.22	enet	48	0.25	1.7e-16	-5.5	5.3	1.2e-07	-0.03	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM149B1	0.04	0.04	enet	6	0.04	5.8e-05	-5.3	-5.3	1.2e-07	0.03	0.02	0.97	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NUDT13	0.13	0.18	blup	34	0.20	7.1e-22	-4.7	5.3	1.2e-07	-0.01	0.05	0.94	FALSE
76	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM149B1	0.04	0.03	blup	45	0.03	2.1e-02	-5.4	-5.3	1.3e-07	0.02	0.02	0.58	FALSE
4	GTEx	Adipose Subcutaneous	FAM149B1	0.10	0.06	lasso	5	0.06	6.3e-06	-5.5	-5.3	1.4e-07	0.02	0.07	0.92	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC18	0.05	0.05	blup	54	0.05	4.7e-06	-5.3	5.3	1.4e-07	-0.03	0.05	0.95	FALSE
17	GTEx	Brain Hippocampus	NUDT13	0.20	0.15	lasso	14	0.12	7.8e-04	-5.5	5.2	1.6e-07	-0.03	0.08	0.80	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM149B1	0.11	0.06	blup	46	0.09	2.1e-04	-5.3	-5.2	1.7e-07	0.02	0.04	0.84	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHCHD1	0.02	0.01	lasso	2	0.01	2.5e-03	5.2	5.2	1.8e-07	-0.04	0.12	0.10	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NUDT13	0.35	0.20	blup	33	0.28	4.9e-12	-5.4	5.2	1.8e-07	-0.02	0.03	0.97	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUDT13	0.08	0.11	lasso	7	0.13	1.4e-14	-5.5	5.2	1.9e-07	-0.03	0.02	0.98	FALSE
46	GTEx	Skin Sun Exposed Lower leg	NUDT13	0.28	0.25	enet	58	0.29	6.0e-24	-5.2	5.2	2.0e-07	-0.03	0.11	0.89	FALSE
6	GTEx	Adipose Subcutaneous	NUDT13	0.33	0.21	lasso	21	0.25	2.5e-20	-4.7	5.2	2.3e-07	-0.03	0.19	0.81	FALSE
22	GTEx	Cells Transformed fibroblasts	FAM149B1	0.22	0.08	lasso	4	0.05	7.6e-05	-5.5	-5.2	2.3e-07	0.04	0.06	0.92	FALSE
42	GTEx	Pancreas	NUDT13	0.14	0.18	lasso	3	0.20	6.0e-09	-4.6	5.2	2.3e-07	-0.03	0.14	0.86	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	BMS1P4	0.05	0.01	enet	4	0.02	8.4e-03	5.3	-5.2	2.3e-07	0.02	0.00	0.88	FALSE
27	GTEx	Colon Transverse	RP11-152N13.16	0.08	0.06	enet	9	0.07	4.7e-04	-5.5	5.2	2.6e-07	-0.03	0.07	0.77	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM149B1	0.25	0.06	lasso	4	0.03	5.2e-03	-5.3	-5.1	2.7e-07	0.03	0.02	0.84	FALSE
12	GTEx	Brain Caudate basal ganglia	NUDT13	0.15	0.17	lasso	19	0.18	7.4e-06	-5.5	5.1	2.8e-07	-0.02	0.06	0.90	FALSE
5	GTEx	Adipose Subcutaneous	C10orf11	0.24	0.21	lasso	9	0.20	3.3e-16	-5.2	5.1	2.9e-07	0.00	1.00	0.00	FALSE
35	GTEx	Lung	NUDT13	0.20	0.18	enet	31	0.22	5.7e-17	-4.4	5.1	3.0e-07	-0.03	0.25	0.75	FALSE