Hub : Genes

NTN4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2930	0.0470	6.2e-15	0.132	0.133	0.212	0.191	0.185	8.4e-16	6.6e-16	2.4e-25	1.1e-22	5.4e-22
2	GTEx	Artery Tibial	0.1159	0.0463	6.3e-03	0.063	NA	0.046	NA	0.074	1.0e-05	NA	1.7e-04	NA	1.9e-06
3	METSIM	Adipose	0.0518	0.0237	1.0e-02	0.000	0.001	-0.001	0.000	-0.002	3.8e-01	1.9e-01	6.4e-01	2.6e-01	9.4e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0696	0.0273	1.4e-04	0.050	0.036	0.050	NA	0.041	2.3e-06	6.5e-05	2.5e-06	NA	2.0e-05
5	TCGA	Lung Adenocarcinoma	0.0387	0.0187	6.8e-03	0.016	0.004	-0.001	NA	0.000	4.4e-03	9.0e-02	4.2e-01	NA	3.2e-01
6	TCGA	Lung Squamous Cell Carcinoma	0.0782	0.0370	4.5e-03	0.003	0.019	0.019	NA	0.016	1.5e-01	2.5e-03	2.7e-03	NA	5.5e-03
7	TCGA	Skin Cutaneous Melanoma	0.4240	0.1280	3.2e-03	0.015	0.058	0.082	NA	0.098	1.3e-01	1.2e-02	3.3e-03	NA	1.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.4	2.2	5.7	-0.9	2.1	0.5	1.5	-0.7	2.4	1.2
Bipolar Disorder or Schizophrenia	0.9	2.3	6.2	-2.2	2.5	1.1	-0.1	-1.4	1.2	0.5
Depressed Affect (Nagel 2018)	0.7	1.4	2.7	0.5	-1.3	1.2	-1.6	-1.2	-0.4	1.6
Depression (Nagel 2018)	1.0	1.5	3.2	0.3	-0.9	1.5	-1.6	-1.1	-1.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.1	0.3	0.0	-0.4	-0.1	0.5	-0.7	-1.4
Neuroticism (Nagel 2018)	0.8	1.8	5.8	0.5	-1.4	0.4	-2.4	-0.7	-0.3	2.0
Schizophrenia (2018)	0.8	1.6	4.0	-2.0	1.4	0.9	-1.4	-1.3	-0.4	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	-0.5	0.8	0.3	-1.3	-0.3	0.0	-0.0
Worry (Nagel 2018)	0.9	1.9	5.6	1.6	-0.6	0.3	-1.7	-1.0	-1.0	2.4
Alzheimer’s Disease (in mother)	2.0	2.4	5.7	-0.2	-0.2	-1.5	0.9	1.5	2.4	-2.4
Alzheimer’s Disease (in father)	0.6	0.6	2.1	0.3	1.4	-0.2	0.2	0.2	0.6	-1.2
Alzheimer’s Disease (including proxy)	1.1	1.5	5.0	0.8	1.1	-0.4	0.7	0.4	1.8	-2.2
Crohns Disease (2017)	0.3	0.6	1.3	-0.5	1.2	0.4	1.1	0.2	0.4	1.0
Irritable Bowel Disease (IBD)	0.3	0.8	2.3	-0.5	0.8	0.3	1.3	0.4	0.7	1.5
Ulcerative Colitis (UC)	0.2	0.4	1.1	0.0	0.3	0.0	0.9	0.5	0.6	1.1
Major Depression (MDD)	3.1	3.8	8.7	-3.0	-2.6	-2.1	-0.7	1.1	0.2	-2.2
Reaction Time	0.4	0.7	2.0	-1.1	-0.2	-0.6	-1.4	-1.1	0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.9	0.5	-1.0	-0.8	-0.4	0.3	-0.7	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.1	1.5	8.4	-0.2	-0.6	0.3	-0.9	-0.0	-2.9	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	1.1	0.4	0.4	0.7	0.8	-0.5	-0.6	1.1
Bipolar Disorder (2011)	0.4	0.4	1.3	-0.4	1.0	1.1	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	6.8	-2.6	-0.1	-1.6	-0.8	0.3	0.6	-1.6
Coronary Artery Disease (CAD)	1.5	1.8	9.2	-0.7	3.0	1.1	0.2	0.0	1.1	0.3
Crohns Disease (2012)	0.2	0.3	1.3	-0.2	0.7	-0.0	0.1	0.5	0.3	1.1
Mean Putamen Volume	0.9	1.0	2.8	-1.5	-0.2	-0.0	-1.7	1.3	0.1	-0.5
Fasting Glucose	0.6	0.7	3.4	-0.3	-0.1	-0.6	-1.9	0.6	-0.7	-0.3
HbA1C	0.6	0.6	1.6	0.3	0.2	-0.8	0.7	0.8	1.2	-1.1
HDL Cholesterol	0.6	0.9	3.9	-0.3	-0.7	2.0	0.0	-0.7	-0.1	-1.3
LDL Cholesterol	0.5	0.7	2.5	-0.2	1.1	-0.3	0.3	0.2	1.6	-1.1
Lupus	1.5	2.3	5.1	1.5	-0.6	2.2	2.2	-1.4	-1.0	0.7
Neuroticism (2016)	0.8	1.2	3.0	0.2	-0.7	1.2	-1.7	0.6	0.5	1.7
Primary Biliary Cirrhosis	1.5	2.2	5.1	-1.2	2.2	0.7	-1.5	-0.1	1.8	1.7
Rheumatoid Arthritis	0.8	1.1	2.9	-1.1	-0.5	0.6	1.7	-0.1	1.6	0.1
Schizophrenia (2014)	0.6	1.4	2.5	-1.6	1.3	1.6	-1.4	-0.9	0.2	-0.3
Triglycerides	0.8	1.4	4.0	1.0	0.9	-0.8	2.0	-1.3	-0.7	0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.3	-0.8	-0.7	-1.2	1.5	-0.9	0.6	-1.3
Ulcerative Colitis	0.1	0.2	0.7	0.1	-0.2	0.6	0.5	-0.1	0.1	0.8
Blood Eosinophil Count	0.1	0.5	1.7	-0.2	0.8	-0.4	0.7	1.3	0.0	0.9
Blood Platelet Count	0.2	2.8	6.4	1.1	1.3	0.9	-0.6	2.1	2.1	2.5
Blood Red Count	0.5	5.0	10.4	1.9	2.8	0.1	0.8	2.2	2.9	3.2
Blood White Count	0.8	6.0	19.5	1.4	1.8	1.7	-1.9	4.4	2.5	2.2
Heel T-Score	0.1	0.7	2.3	-0.5	1.5	1.2	0.0	0.0	0.8	0.2
BMI	0.2	1.3	3.0	-1.3	-1.4	-0.7	-1.7	0.8	-1.2	0.0
Height	0.1	1.6	3.0	1.0	-0.2	-1.7	1.2	-1.6	-0.8	1.7
Waist Hip Ratio (WHR)	0.7	3.1	9.1	2.1	1.9	1.3	-3.0	0.7	0.8	1.3
Systolic Blood Pressure	0.3	1.5	3.3	-0.6	-1.5	0.5	-1.7	1.8	-0.8	-0.7
Smoking Status	0.5	1.3	4.0	0.5	-1.4	1.7	0.1	0.5	0.1	2.0
Allergy or Eczema	1.6	4.2	12.6	-0.9	-3.5	-0.6	-0.1	-0.9	-1.5	-3.5
Cardiovascular Disease	0.7	2.5	8.0	-0.4	-2.8	0.4	-2.3	1.5	-0.8	0.8
Hypothyroidism (self reported)	0.3	0.7	2.8	-0.2	-0.2	1.7	-0.8	1.0	-0.5	0.3
Respiratory disease	0.2	0.5	1.2	0.2	-1.1	-0.8	-1.1	-0.2	0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.5	0.7	1.6	0.4	-0.9	0.7	1.9	1.1
Lung FEV1/FVC ratio	3.4	17.2	50.6	-3.2	2.2	1.8	5.6	-7.1	4.1	1.9
Lung FVC	0.3	1.5	5.5	0.6	-1.2	0.1	0.5	2.3	1.0	-1.3
Neuroticism	0.8	2.0	10.6	0.5	-1.2	0.7	-3.2	0.4	-0.1	1.2
Chronotype (morning person)	0.3	0.7	2.6	0.0	-0.5	-1.6	-0.6	1.3	-0.4	0.1
Hair Pigment	0.1	1.8	3.1	0.7	-1.6	1.1	1.8	1.1	1.3	-1.6
Tanning	0.2	2.0	7.2	-1.6	1.5	-2.7	0.6	0.8	0.2	-1.0
Hand grip strength (left)	0.3	0.7	1.7	0.7	0.1	1.2	1.0	-1.3	-0.3	0.2
Number of treatments/medications taken	0.5	1.0	3.8	-0.5	-0.7	-0.4	-0.0	2.0	1.3	-0.5
Average weekly spirits intake	0.2	0.3	0.7	-0.6	-0.4	-0.4	-0.6	-0.1	0.2	0.8
Sensitivity / hurt feelings	1.1	1.9	7.8	-1.7	-0.9	-0.6	-2.8	1.3	0.2	-0.2
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.4	0.3	-1.4	1.2	-0.7	-0.2	-1.6	0.2
Hearing difficulty/problems: Yes	0.6	0.9	3.1	-1.4	0.4	0.5	-0.1	-1.8	0.4	0.9
Relative age of first facial hair	0.5	1.0	2.4	0.7	1.0	-0.8	-1.4	-0.3	-1.6	0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.5	-0.7	1.3	-0.6	-0.4	1.9	1.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.0	0.3	-0.4	-0.2	-0.2	-1.7	0.1	1.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.5	0.5	0.2	0.1	-0.1	-0.2	0.9	1.2
Systolic blood pressure, automated reading	0.2	0.6	1.8	-0.4	-0.5	0.4	-1.4	1.1	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.0	-0.1	-1.1	-0.3	0.3	0.5	1.4	1.7
Angina	0.7	0.9	2.1	-0.8	1.4	0.2	-0.4	0.6	1.4	-1.0
Medication for hormone replacement therapy	1.1	1.2	2.9	1.0	-1.7	0.2	1.3	-1.6	0.0	0.6
Vitamin and mineral supplements	0.2	0.3	0.8	-0.6	0.2	-0.8	-0.5	0.4	0.9	-0.3
Supplements: Zinc	1.2	1.3	4.7	0.2	1.1	1.3	0.9	-0.5	0.6	2.2
Medication: Co-codamol	1.2	1.3	5.6	0.3	-2.4	0.7	-0.0	1.3	0.7	-1.0
Medication: Metformin	0.6	0.9	3.1	-0.0	1.2	-0.1	-0.8	0.7	1.8	0.8
Diabetes (father)	1.4	1.7	8.9	-0.4	-0.2	0.4	-0.5	3.0	1.5	0.3
Diabetes (mother)	0.5	0.6	1.3	0.9	-0.7	-1.1	-0.1	1.0	-0.9	0.0
Severe depression (siblings)	1.4	1.5	4.1	0.3	-1.6	1.6	-0.1	-1.2	0.0	2.0
Pack years adult smoking proportion	1.0	1.5	5.9	-0.7	-0.1	-0.3	-0.9	2.4	0.0	-1.7
Impedance of leg (right)	0.3	1.5	5.5	0.5	1.9	2.3	0.1	-0.9	0.8	0.1
Leg fat-free mass (left)	0.2	0.9	3.3	0.3	-0.3	-1.6	0.1	0.1	0.0	1.8
Trunk fat percentage	0.5	2.0	3.8	-0.6	1.9	-1.9	-1.7	1.2	1.3	0.8
Hand grip strength (right)	0.4	1.2	3.2	0.9	0.2	0.3	1.4	-1.8	-1.2	0.8
Townsend deprivation index at recruitment	0.6	0.9	2.5	1.6	-0.2	0.8	1.2	-0.5	-1.2	0.0
Current tobacco smoking	0.3	0.5	1.3	-0.2	-0.6	1.1	-0.4	0.9	0.4	0.8
Average weekly fortified wine intake	0.7	0.9	2.8	0.1	-0.2	1.7	-1.0	-0.5	-1.2	0.8
Maternal smoking around birth	0.7	1.0	2.5	0.8	-1.6	-1.0	-0.4	0.5	-1.4	-0.9
Fed-up feelings	0.9	1.6	3.8	-0.9	-1.9	1.3	-1.8	0.5	-0.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	0.0	-0.5	1.2	-1.3	-0.9	-0.6	1.1
Relative age voice broke	0.5	0.8	1.5	0.2	-0.2	-1.1	1.2	-1.1	-1.1	0.5
Taking other prescription medications	0.5	0.8	4.6	0.2	-0.0	-0.1	-0.8	2.1	0.4	0.0
Age when periods started (menarche)	0.6	1.5	4.9	0.8	-1.0	1.8	0.9	-0.2	0.1	2.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	-1.6	-0.7	-0.9	0.4	-1.3	-0.7	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.8	-0.2	0.6	-0.4	0.2	-0.3	1.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.6	0.1	-0.9	0.3	-1.6	-0.3	-0.3	-0.2
Qualifications: CSEs or equivalent	1.5	1.9	5.3	1.2	1.2	-1.4	0.8	2.3	1.2	1.1
Serious illness, injury or assault to yourself	0.9	1.1	4.7	-0.5	0.1	0.6	-2.2	0.3	-1.4	-0.4
High blood pressure	1.4	3.9	8.2	-1.9	-2.9	-2.2	-2.2	2.0	-0.7	-1.2
Hayfever, allergic rhinitis or eczema	1.2	2.7	8.6	0.0	-2.9	-0.0	-0.2	-0.9	-1.4	-2.7
Multivitamins +/- minerals	1.7	2.1	3.4	1.5	-0.8	0.5	1.8	-1.6	-1.8	1.6
Stomach or abdominal pain in last month	1.1	1.3	3.7	-0.1	-0.5	1.7	-0.8	-0.6	-1.2	1.9
Supplements: Glucosamine	1.2	1.6	4.2	0.6	0.9	2.0	1.3	-1.9	0.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	0.6	1.2	0.5	-0.1	-1.4	-0.8	1.1
Medication: Atenolol	1.1	1.4	2.9	-1.7	-1.3	-1.0	-0.9	1.1	1.1	-1.0
Medication: Levothyroxine sodium	0.4	0.7	2.7	-0.7	-1.6	1.2	-0.4	0.3	-0.2	0.5
Sitting height	0.2	1.3	3.3	0.3	0.1	-1.0	1.8	-1.5	0.4	1.5
Chronic bronchitis/emphysema (father)	2.0	2.4	8.1	1.2	-0.5	0.5	1.4	-2.8	-1.4	1.6
High blood pressure (mother)	1.9	2.6	8.0	-1.0	-2.2	-0.6	-0.8	2.8	1.5	-1.3
Body mass index (BMI)	0.2	1.0	2.8	-0.9	0.1	-1.4	-1.1	1.7	0.5	0.4
Impedance of leg (left)	0.1	0.7	2.0	0.4	1.3	1.4	-0.1	-0.8	0.6	-0.3
Leg predicted mass (left)	0.2	0.8	3.2	0.3	-0.4	-1.6	0.2	0.1	-0.1	1.8
Trunk fat mass	0.4	1.6	3.6	-0.2	1.6	-1.9	-1.3	0.8	1.0	1.3
Waist circumference	0.5	1.7	4.7	-0.2	1.4	-1.4	-2.2	1.3	0.7	1.0
Number of incorrect matches in round	0.5	0.9	2.8	0.2	0.7	0.0	1.7	-0.1	1.5	-0.9
Past tobacco smoking	0.1	0.2	0.6	0.6	0.8	-0.2	-0.2	0.2	0.2	-0.8
Alcohol usually taken with meals	0.3	0.4	1.1	0.1	0.2	-1.1	0.2	-0.2	-0.7	1.1
Nervous feelings	1.3	2.4	8.9	1.9	0.6	1.6	-1.1	-0.2	-0.5	3.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.1	0.8	-0.7	1.7	-1.1	-0.7	-0.7	1.7
Hearing difficulty/problems with background noise	0.7	1.2	3.0	-0.5	0.9	1.5	-1.0	0.3	1.7	0.9
Hair/balding pattern: Pattern 2	1.7	2.2	7.8	1.0	-1.7	1.2	0.1	-0.4	-2.8	-1.3
Had menopause	0.8	1.0	3.2	-0.7	0.2	-1.2	-1.0	-0.1	1.8	-0.8
Had other major operations	0.4	0.5	1.3	-0.6	-1.1	-1.1	0.6	0.3	-0.1	-0.5
Forced vital capacity (FVC)	0.3	1.0	2.3	1.5	-0.8	0.9	1.5	-0.4	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	-0.3	-0.6	-0.3	0.2	0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.7	-1.0	-0.8	-0.6	-0.3	-0.6	-0.7
Qualifications: None of the above	0.5	1.0	2.7	-0.9	-0.5	1.1	-0.4	-1.2	1.6	-0.6
Financial difficulties in last 2 years	0.6	0.8	2.6	1.6	0.4	-1.3	0.2	0.1	0.0	1.1
Mouth/teeth dental problems	0.3	0.4	1.3	-0.1	-0.6	-0.4	0.6	0.8	-1.1	-0.0
Heart attack	0.6	0.8	2.7	0.0	0.7	0.5	0.5	1.2	1.6	-0.5
Allergy	0.4	0.9	3.1	-0.9	1.8	0.3	0.4	1.0	1.1	0.6
Pain all over the body in last month	0.4	0.5	1.5	0.0	-0.5	0.3	0.4	0.7	-1.2	-0.9
Diabetes (self-reported)	0.7	1.0	3.9	-0.8	-0.3	-0.1	-1.3	0.9	2.0	0.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	7.0	0.7	-2.6	0.8	0.5	-0.9	-2.6	-0.9
Medication: Ramipril	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.7	0.2	-0.4	-0.2
Medication: Simvastatin	0.3	0.4	1.8	-1.4	-0.7	-0.5	-0.5	0.0	-0.3	-0.3
Fluid intelligence score	0.2	0.5	1.0	0.8	-0.7	-0.9	-0.3	0.5	-1.0	0.6
Illnesses of siblings	0.6	0.8	1.7	-0.3	1.3	1.2	0.3	0.2	0.8	-1.2
Neuroticism score	0.7	1.4	4.5	0.4	-1.1	0.2	-2.1	0.2	-0.5	1.9
Weight	0.2	0.9	2.9	-0.0	0.6	-1.7	-0.2	0.4	0.6	1.7
Impedance of arm (right)	0.3	1.2	4.6	1.2	2.1	0.2	-0.6	0.3	1.3	-0.4
Arm fat percentage (right)	0.5	1.9	3.6	-0.3	1.6	-1.7	-1.6	1.9	1.2	0.4
Trunk fat-free mass	0.2	0.9	4.3	0.9	-0.3	-0.8	0.7	-0.4	-0.1	2.1
Hip circumference	0.2	1.0	3.0	-0.9	0.9	-1.7	-0.3	0.8	1.2	0.7
Time employed in main current job	0.3	0.3	1.2	-0.3	1.0	-0.2	0.0	-1.1	0.3	0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.1	0.9	-0.1	-1.0	0.2	0.9	-0.8	-1.1
Father’s age at death	1.9	2.5	7.2	1.1	-2.7	-1.2	-1.6	0.0	-1.8	-1.3
Worrier / anxious feelings	0.7	1.4	3.1	-0.1	-1.8	-0.9	-0.9	1.1	1.3	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.1	0.6	-2.1	1.7	-1.3	-1.6	-2.3	1.2
Falls in the last year	0.8	1.1	2.7	-0.1	-1.0	-1.3	-1.2	-0.9	-1.6	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.4	-1.5	0.7	-0.1	-0.2	-1.4	-0.2	-0.3
Number of live births	0.8	1.1	3.0	-0.8	0.7	0.1	1.4	0.7	1.7	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	7.8	0.3	-0.1	1.0	2.8	-2.1	1.1	1.7
Pulse rate	0.2	0.4	2.2	-0.3	0.5	0.1	-0.1	-1.5	0.5	0.3
Happiness	0.4	0.5	1.2	0.4	-0.8	0.3	1.1	-0.2	0.9	-0.8
Noisy workplace	0.9	1.1	3.5	0.6	-1.9	1.4	0.2	1.3	0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.0	0.5	-1.4	-0.4	1.1	-2.0	-1.3	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	2.7	-0.5	0.5	1.1	-1.6	0.2	0.2	0.5
Mouth/teeth dental problems: Dentures	0.7	1.2	5.2	-0.5	0.7	1.3	0.0	-0.8	2.3	0.0
Asthma	0.2	0.4	1.5	0.6	-1.2	-0.8	-0.1	0.1	0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.5	-0.3	0.3	0.2	0.1	0.4	0.0
Medication: Cholesterol lowering	0.4	0.6	1.8	-0.2	-1.0	-0.8	-0.6	1.4	0.2	-0.2
Depression (self-reported)	0.9	1.0	3.2	0.7	0.2	0.8	-1.1	-0.5	-1.2	1.8
Medication: Lansoprazole	1.1	1.3	6.0	-0.5	0.7	0.6	-2.5	0.6	-1.0	-0.5
Prospective memory result	1.2	1.4	3.5	0.5	0.5	-1.0	-1.3	1.9	-0.4	-1.8
Lung cancer (father)	1.5	1.8	3.4	0.8	-0.9	1.9	0.4	1.8	-1.3	1.6
Illnesses of mother	2.1	2.5	10.3	0.3	1.0	1.3	0.8	-3.2	-1.3	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	10.9	0.5	0.7	1.3	3.3	-3.2	1.5	2.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	-1.0	-0.0	1.2	-0.6	1.0	1.3	0.3
Impedance of arm (left)	0.3	1.6	6.2	1.4	2.5	-0.2	-0.4	-0.7	1.5	0.3
Arm fat mass (right)	0.3	1.3	3.4	-0.2	0.9	-1.8	-1.1	1.5	0.8	0.7
Trunk predicted mass	0.2	0.9	4.3	0.9	-0.3	-0.8	0.5	-0.3	-0.1	2.1
Standing height	0.3	3.4	9.1	2.0	1.5	-0.7	1.5	-2.4	0.4	3.0
Length of working week for main job	0.2	0.3	0.6	0.2	0.8	0.7	0.5	-0.6	-0.1	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.5	-0.7	-0.5	0.1	-1.0	0.6	0.7	-1.2
Breastfed as a baby	1.8	2.2	8.6	-1.2	1.0	-1.5	0.7	1.3	2.9	-0.3
Tense / ‘highly strung’	0.8	1.3	6.8	2.6	-0.4	0.6	-0.4	-0.5	-0.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.7	0.8	-2.2	-0.2	-0.2	-0.3	-1.5	0.9
Hair/balding pattern: Pattern 4	0.2	0.4	1.7	-0.3	0.9	-0.4	0.2	0.4	1.3	-0.3
Birth weight of first child	0.2	0.4	0.9	-0.9	0.5	-0.7	-0.5	-0.5	-0.7	-0.5
Peak expiratory flow (PEF)	0.7	1.7	5.3	0.1	0.6	-0.6	1.6	-2.3	0.4	1.8
Pulse wave reflection index	0.7	0.8	3.2	0.1	-1.8	-0.1	-0.0	0.8	-0.1	1.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.7	0.3	0.9	-1.5	0.1	-0.4	0.9	2.2
Loud music exposure frequency	0.2	0.2	1.1	0.2	-0.1	-0.2	-0.2	-1.1	0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	1.8	-1.4	0.8	0.7	-0.8	-1.0	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.0	-0.4	-1.1	-0.4	-0.6	-1.3	-0.2	1.7
Blood clot in the leg (DVT)	1.6	2.1	6.1	1.8	-0.3	1.9	-0.2	-0.3	-1.2	2.5
Medication: Paracetamol	0.7	1.2	3.6	-1.9	-0.6	-1.2	-0.0	-0.4	1.6	-0.9
Headache pain in last month	1.1	1.9	5.2	1.1	-2.3	1.8	-0.1	-0.9	-0.9	1.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	4.7	0.8	2.2	1.3	1.0	-1.7	0.0	-0.1
Glaucoma (self-reported)	0.3	0.3	0.6	-0.6	0.7	-0.1	0.4	-0.4	0.7	-0.8
Gout (self-reported)	2.2	3.0	6.7	-1.4	-1.1	-1.6	-1.2	2.6	0.5	-2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-1.0	-0.8	1.0	-0.6	0.9	-0.4	-0.0
Medication: Amlodipine	0.8	1.1	4.5	1.1	-2.1	-0.0	0.0	-1.2	-0.6	0.5
Medication: Ventolin 100micrograms inhaler	1.9	2.5	7.4	-0.4	-2.7	-0.8	-2.2	1.8	-0.6	-0.8
Birth weight	0.7	1.6	3.1	1.0	-1.4	1.1	1.8	-1.4	1.0	1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	0.5	-0.9	-1.2	0.2	1.3	-0.7	-0.7
High blood pressure (siblings)	0.9	1.3	3.7	1.1	-1.5	-0.7	0.8	-0.9	-0.1	1.9
Forced vital capacity (FVC), Best measure	0.5	1.8	4.3	1.2	-0.2	0.9	2.1	-1.4	0.8	1.8
Body fat percentage	0.5	1.8	3.1	-0.6	1.8	-1.6	-1.7	1.3	1.1	1.0
Leg fat percentage (right)	0.4	1.4	3.1	-0.8	1.6	-0.3	-1.8	1.3	0.9	0.6
Arm fat-free mass (right)	0.2	0.9	3.8	-0.0	-0.5	-1.2	0.5	-0.7	-0.2	2.0
Exposure to tobacco smoke outside home	0.4	0.6	2.2	1.5	-0.7	-0.0	0.6	-0.4	-0.6	0.7
Comparative body size at age 10	0.4	1.0	3.5	-1.2	-0.1	-0.8	0.0	-1.9	0.3	-1.2
Number of full brothers	0.7	0.9	4.3	-0.8	0.0	0.2	0.9	-0.4	2.1	0.4
Worry too long after embarrassment	0.4	0.7	2.3	-0.5	-1.5	0.2	-0.8	-0.6	0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.6	1.2	-1.3	1.3	-1.7	-0.3	-1.9	1.4
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	-0.2	-0.0	-0.0	-1.5	0.5	0.9	-0.7
Number of children fathered	0.1	0.1	0.2	-0.0	-0.2	0.5	-0.2	0.5	-0.0	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.6	0.5	-1.3	-0.5	0.7	0.0	0.1	-0.3
Age at first live birth	1.0	1.8	5.1	1.1	2.3	-1.3	0.0	-1.3	-0.9	1.4
Pulse wave peak to peak time	0.8	0.9	1.9	0.9	-0.1	-1.2	0.8	-1.1	-1.4	-0.3
Health satisfaction	0.8	1.0	2.4	0.4	0.7	0.4	-1.3	1.4	-0.6	-1.5
Shortness of breath walking on level ground	0.8	1.0	3.1	-0.9	-0.2	-0.6	-1.8	1.2	-0.2	-1.1
Qualifications: College or University degree	0.3	0.9	2.3	0.6	1.5	-1.1	-0.6	-0.8	-0.9	0.7
Eye problems/disorders: None of the above	0.4	0.4	1.3	0.3	0.9	0.8	-0.3	0.3	-1.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.1	0.2	-1.0	1.5	0.6	0.1	0.2	0.1
Emphysema/chronic bronchitis	1.0	1.1	2.6	-0.2	1.2	-0.4	-1.6	1.2	1.4	0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	4.6	1.5	0.1	-0.2	0.8	-1.4	-2.2	1.2
Neck or shoulder pain in last month	0.2	0.3	1.1	-0.2	-0.1	0.4	-0.7	0.4	1.1	-0.0
Medication: Blood pressure	1.2	2.0	5.9	-0.7	-2.4	-2.0	-0.5	1.5	0.2	-1.0
Angina (self-reported)	0.6	0.7	2.2	-0.6	1.1	0.3	-0.3	0.8	1.5	-0.8
Migraine (self-reported)	0.1	0.1	0.2	0.4	-0.3	0.2	0.1	0.4	-0.2	-0.0
Medication: Ibuprofen	0.2	0.2	0.4	0.3	-0.6	0.6	0.4	0.0	-0.3	0.7
Medication: Allopurinol	2.4	3.2	9.0	-0.4	-0.2	-1.6	-1.6	2.6	1.0	-3.0
Medication: Omeprazole	1.0	1.2	4.4	-0.7	1.3	-0.1	0.0	2.1	0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	3.9	0.9	-0.3	-1.6	2.0	-0.0	-0.2	-0.6
Mean time to correctly identify matches	0.4	0.7	2.5	-1.1	-0.4	-1.6	-0.7	-0.2	0.1	-0.9
Heart disease (mother)	0.5	0.7	2.8	-0.3	1.7	-0.1	0.1	1.0	0.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.4	-0.8	-1.6	-0.6	-0.0	0.7	-1.2	-0.7
Whole body fat mass	0.3	1.4	3.0	-0.3	1.4	-1.7	-1.1	0.8	0.8	1.4
Leg fat mass (right)	0.3	1.1	1.9	-0.9	1.0	-0.9	-1.4	1.3	0.8	0.8
Arm predicted mass (right)	0.2	0.8	3.5	-0.3	-0.4	-1.2	0.3	-0.4	-0.3	1.9
Pulse rate, automated reading	0.1	0.4	1.2	-0.5	-0.7	0.3	-0.4	-0.7	-0.5	1.1
Alcohol intake frequency.	0.3	0.7	2.1	0.5	-0.6	-1.1	0.4	1.0	-0.3	-1.4
Comparative height size at age 10	0.4	2.0	4.1	0.7	1.1	-0.8	2.0	-2.0	-0.7	1.8
Number of full sisters	1.6	1.9	4.1	-0.9	-1.7	-1.8	-0.6	2.0	0.4	-1.4
Suffer from ‘nerves’	1.0	1.6	5.1	2.1	-0.2	0.7	-0.5	-0.7	-0.5	2.3
Overall health rating	0.8	1.8	8.7	-0.2	0.9	-0.1	-2.9	1.4	0.8	-0.6
Chest pain or discomfort	0.2	0.3	0.7	0.8	0.4	-0.3	-0.4	0.5	-0.8	-0.3
Had major operations	1.4	1.7	4.1	-1.0	-2.0	-1.5	-0.8	1.4	-0.8	1.1
Age at last live birth	1.6	2.3	4.8	2.2	1.8	-1.6	1.3	-1.1	0.8	1.4
Family relationship satisfaction	1.6	1.9	4.7	1.5	0.3	-1.8	-1.0	1.2	-2.2	-0.8
Leg pain on walking	1.0	1.2	4.1	-0.1	0.4	-2.0	-1.3	0.7	-0.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.2	-0.7	-0.2	0.3	1.1	1.8	1.5	0.4
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.4	-1.7	-0.7	-0.2	-1.7	1.5	-0.7	-2.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-0.6	-1.0	-1.0	1.1	1.4	1.2	-0.4
Medication: Aspirin	0.3	0.4	1.0	0.2	0.6	0.6	0.0	1.0	0.7	-0.3
Supplements: Vitamin C	1.2	1.4	4.1	-1.4	2.0	0.5	-0.5	0.9	1.6	-0.0
Knee pain experienced in last month	0.7	1.1	1.6	-1.0	-1.3	1.3	0.8	0.8	0.7	-1.2
Hypertension (Self-reported)	1.7	4.7	7.9	-2.1	-2.8	-2.3	-2.8	2.2	-0.3	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.4	-0.9	0.2	-1.1	-2.5	2.0	0.0	-1.5
Illnesses of father: Heart disease	1.2	1.7	7.2	-2.7	1.8	-0.6	0.1	0.2	0.8	0.5
Illnesses of siblings: Diabetes	1.0	1.2	2.8	-1.6	0.1	-0.9	0.5	0.9	1.7	1.2
Smoking status: Previous	0.1	0.2	0.7	-0.2	-0.8	0.6	-0.1	0.2	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	9.5	1.1	0.5	0.8	0.3	-1.4	-0.6	3.1
Whole body fat-free mass	0.2	1.0	4.3	0.5	-0.5	-1.2	0.6	-0.3	-0.1	2.1
Leg fat-free mass (right)	0.2	1.1	3.7	0.2	-0.7	-1.9	0.3	0.1	0.0	1.8
Arm fat percentage (left)	0.5	2.0	3.6	-0.3	1.6	-1.9	-1.7	1.6	1.4	0.7
Average weekly red wine intake	0.4	0.6	1.8	0.6	0.6	-0.2	1.4	-0.8	0.3	0.8
Handedness (chirality/laterality): Left-handed	1.5	1.7	6.5	-0.4	-1.6	1.3	2.5	-0.6	-0.5	0.9
Mood swings	0.5	1.0	2.6	0.3	-1.6	1.2	-1.0	-0.7	-0.8	0.7
Loneliness, isolation	0.6	0.8	3.1	0.4	0.7	-0.5	-1.7	0.9	0.3	1.0
Long-standing illness, disability or infirmity	1.3	2.0	6.5	-0.5	-0.2	0.1	-2.5	2.1	0.4	-1.8
Ever had bowel cancer screening	1.1	1.3	4.1	0.3	0.0	2.0	-1.5	-0.1	-0.1	-1.6
Diabetes diagnosed by doctor	0.4	0.7	3.1	-0.4	0.6	-0.3	-0.9	0.7	1.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.4	0.7	0.1	-0.0	-0.0	0.7	0.3
Friendships satisfaction	1.4	1.8	5.7	-0.4	-0.1	-0.2	-2.4	-0.1	-1.8	-1.8
Qualifications: nursing, teaching	0.3	0.4	1.3	0.8	0.2	-1.1	-0.8	0.4	-0.1	-0.5
Commuting to job workplace: Walk	1.4	1.5	6.0	-0.4	0.9	-0.7	1.5	-0.3	2.5	0.9
Eye problems/disorders: Cataract	0.6	0.7	1.8	-1.0	-0.5	-0.6	-0.4	1.1	1.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	0.1	0.6	-0.9	-0.1	-0.8	-0.2	-1.0
Medication for cholesterol	0.2	0.3	1.0	0.5	1.0	0.1	0.2	-0.5	0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	7.4	0.8	-0.2	0.8	2.4	-2.7	-0.5	1.0
Back pain experienced in last month	0.6	0.9	2.2	0.4	-1.0	1.5	-0.7	0.7	1.4	-0.5
Mineral and other dietary supplements	0.8	1.0	4.4	-0.6	-1.1	-2.1	0.9	0.1	0.3	-0.5
Breast cancer (self-reported)	0.9	1.1	2.9	-0.7	-0.2	0.0	-0.3	-1.4	-1.5	1.7
Asthma (self-reported)	0.2	0.3	1.0	0.8	-1.0	-0.5	0.2	-0.0	0.6	0.2
Osteoporosis (self-reported)	0.7	0.8	2.8	-0.8	0.1	0.1	0.3	1.0	1.7	-1.2
Osteoarthritis (self-reported)	0.6	0.8	1.8	-0.5	-1.3	1.0	-0.1	1.0	0.2	-1.2
Medication: Aspirin	0.1	0.1	0.2	0.2	-0.1	0.5	0.1	0.3	0.4	-0.3
Medication: Gliclazide	0.4	0.4	1.3	1.1	-0.4	0.6	0.1	0.6	-0.6	0.7
Illnesses of father: None of the above (group 1)	0.5	0.6	3.1	1.8	0.2	-0.1	0.7	0.5	0.6	-0.3
Smoking status: Current	0.2	0.4	1.1	-0.3	-0.3	1.1	-0.3	0.6	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.6	0.7	-0.1	-0.3	1.9	-1.5	0.8	0.1
Whole body water mass	0.2	0.9	4.2	0.3	-0.4	-1.1	0.5	-0.2	-0.1	2.0
Leg predicted mass (right)	0.2	1.1	4.0	0.2	-0.5	-2.0	0.2	0.1	0.0	1.8
Arm fat mass (left)	0.3	1.2	2.9	-0.0	1.0	-1.7	-0.9	1.3	0.9	1.2
Number of self-reported non-cancer illnesses	2.1	3.6	7.5	-1.3	-2.3	-0.9	-2.7	2.7	-0.9	-1.3
Average weekly champagne plus white wine intake	0.9	1.2	3.8	-0.4	-0.7	-1.6	-1.9	0.8	-0.7	-0.2
Miserableness	0.6	1.0	2.1	-0.5	-1.0	1.2	-0.8	-1.1	0.2	1.5
Guilty feelings	0.7	1.0	5.0	-0.4	-1.2	0.4	-2.2	0.5	-0.3	-0.5
Wears glasses or contact lenses	0.5	0.5	1.2	-0.6	1.1	0.7	0.4	-0.1	1.1	0.4
Ever taken oral contraceptive pill	0.8	0.8	2.7	0.3	-0.5	0.2	0.8	-0.9	-1.2	1.6
Hearing aid user	1.6	1.9	5.3	-1.9	-0.8	-0.3	-2.3	1.0	-1.2	-1.0
Mother’s age at death	0.7	0.9	4.2	2.1	-1.0	-0.5	0.3	-0.4	-0.7	0.2
Financial situation satisfaction	0.7	0.9	3.9	-0.6	-2.0	-0.6	-0.2	0.1	-0.8	-1.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.4	1.2	-1.0	1.4	-0.3	-0.7	-1.6	-0.4
Commuting to job workplace: Public transport	0.7	0.8	2.4	1.6	-0.3	-0.3	0.0	-1.1	-0.8	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.8	0.6	1.0	0.1	-0.9	-0.0	-0.0
Medication: Blood pressure	0.9	1.7	4.6	-1.4	-1.5	-0.0	-2.2	1.2	-0.4	-1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.9	-1.1	0.1	0.4	0.6	0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.5	1.1	0.3	1.6	-0.4	0.9	0.4	0.2
High cholesterol (Self-reported)	1.0	1.8	4.7	-1.2	-2.2	-0.4	-1.7	1.2	-1.1	-0.8
Medication: Bendroflumethiazide	2.6	4.0	6.6	-1.4	-1.3	-2.6	-2.5	2.2	0.2	-2.5
Medication: Paracetamol	0.9	1.4	3.8	-1.9	-0.3	-0.7	0.7	-1.2	1.7	-0.7
Medication: Lisinopril	1.8	2.3	5.2	-0.5	-1.0	-0.8	-2.3	2.3	-0.6	-1.9
Medication: Atorvastatin	0.9	1.1	3.7	-0.3	-1.9	0.3	-0.1	1.7	0.5	-0.8
Illnesses of father: High blood pressure	0.7	0.9	2.0	-0.8	-1.4	0.9	-1.0	-0.3	-1.1	0.9
Alcohol drinker status: Never	1.7	2.0	8.5	0.5	-0.5	2.9	1.1	-0.1	1.5	1.2
Ever smoked	0.5	0.9	1.6	-0.6	-0.9	-0.1	1.1	-1.2	-0.8	1.2
Basal metabolic rate	0.2	0.9	4.2	0.4	-0.2	-1.3	0.4	0.0	0.0	2.1
Leg fat percentage (left)	0.4	1.4	3.5	-0.9	1.2	-1.0	-1.9	1.5	0.9	0.4
Arm fat-free mass (left)	0.1	0.7	3.0	0.0	-0.4	-1.1	0.5	0.2	-0.2	1.7
Number of operations (self-reported)	1.0	1.5	2.7	-1.3	-1.7	-1.5	-1.2	1.2	-0.2	0.6
Average weekly beer plus cider intake	0.2	0.4	1.1	0.3	-0.8	0.0	1.0	0.3	-0.7	-0.1
Irritability	0.5	0.8	1.6	0.3	0.5	-1.3	-1.0	1.2	0.5	1.2
Risk taking	0.6	0.9	3.2	0.5	-1.0	0.3	1.8	-1.1	-0.4	0.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.4	-0.4	-1.4	-1.0	-0.5	1.3	-1.8	-0.5
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-0.7	0.5	0.4	1.3	-0.6	0.5	1.1
Age started oral contraceptive pill	0.8	1.0	1.9	-0.6	0.5	-1.4	-1.2	1.1	0.9	-1.0
Diastolic blood pressure, automated reading	0.8	2.4	10.7	0.4	-3.3	-0.0	-0.2	1.8	-1.7	0.3
Ever depressed for a whole week	0.7	0.9	3.5	-1.1	-1.9	-0.8	-0.4	-0.5	-0.5	0.7
Unable to work because of sickness or disability	0.2	0.2	0.4	0.4	-0.6	0.3	0.5	0.5	0.1	0.6
Commuting to job workplace: Cycle	1.2	1.4	5.0	1.2	-1.2	-0.3	2.2	-0.9	0.4	1.0
Myopia	1.0	1.5	3.9	-1.8	0.8	-1.0	-0.3	0.8	0.9	-2.0
Vascular/heart problems diagnosed by doctor	1.1	3.1	5.5	1.9	2.1	1.5	2.3	-1.9	0.6	1.3
Cholesterol lowering medication	0.8	1.2	2.3	-1.1	1.0	-0.7	0.3	1.5	1.0	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.8	-0.1	1.8	-0.3	-0.5	2.2	-0.0	-1.0
Pain experienced in last month	0.9	1.5	7.4	-0.2	2.7	-0.7	-1.0	-1.0	-0.9	-0.2
Supplements: Calcium	0.3	0.3	0.8	0.0	0.7	-0.9	-0.2	0.7	0.5	0.4
Basal cell carcinoma (self-reported)	1.2	1.4	5.2	0.9	-0.5	1.5	2.3	0.1	-0.4	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.0	-0.2	0.8	0.1	0.4	1.4	1.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	6.1	1.9	0.1	1.8	0.4	-0.7	-0.9	2.5
Heart disease (siblings)	0.4	0.5	1.2	0.1	0.8	-0.6	-1.0	-0.6	-1.1	-0.3
Alcohol drinker status: Previous	1.3	1.5	3.2	1.2	-1.8	-1.3	0.6	-1.2	-1.4	0.6
Pack years of smoking	1.3	2.0	5.9	-0.9	-0.1	-0.6	-0.9	2.4	0.2	-2.4
Impedance of whole body	0.2	1.2	5.2	0.9	2.3	0.5	-0.2	-0.9	1.0	0.1
Leg fat mass (left)	0.3	1.0	1.9	-0.9	0.5	-1.3	-1.3	1.4	0.7	0.7
Arm predicted mass (left)	0.1	0.7	3.3	0.1	-0.4	-1.1	0.5	-0.0	-0.2	1.8