Hub : Genes

NTN4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2930 0.0470 6.2e-15 0.132 0.133 0.212 0.191 0.185 8.4e-16 6.6e-16 2.4e-25 1.1e-22 5.4e-22
2 GTEx Artery Tibial 0.1159 0.0463 6.3e-03 0.063 NA 0.046 NA 0.074 1.0e-05 NA 1.7e-04 NA 1.9e-06
3 METSIM Adipose 0.0518 0.0237 1.0e-02 0.000 0.001 -0.001 0.000 -0.002 3.8e-01 1.9e-01 6.4e-01 2.6e-01 9.4e-01
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0696 0.0273 1.4e-04 0.050 0.036 0.050 NA 0.041 2.3e-06 6.5e-05 2.5e-06 NA 2.0e-05
5 TCGA Lung Adenocarcinoma 0.0387 0.0187 6.8e-03 0.016 0.004 -0.001 NA 0.000 4.4e-03 9.0e-02 4.2e-01 NA 3.2e-01
6 TCGA Lung Squamous Cell Carcinoma 0.0782 0.0370 4.5e-03 0.003 0.019 0.019 NA 0.016 1.5e-01 2.5e-03 2.7e-03 NA 5.5e-03
7 TCGA Skin Cutaneous Melanoma 0.4240 0.1280 3.2e-03 0.015 0.058 0.082 NA 0.098 1.3e-01 1.2e-02 3.3e-03 NA 1.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.4 2.2 5.7 -0.9 2.1 0.5 1.5 -0.7 2.4 1.2
Bipolar Disorder or Schizophrenia 0.9 2.3 6.2 -2.2 2.5 1.1 -0.1 -1.4 1.2 0.5
Depressed Affect (Nagel 2018) 0.7 1.4 2.7 0.5 -1.3 1.2 -1.6 -1.2 -0.4 1.6
Depression (Nagel 2018) 1.0 1.5 3.2 0.3 -0.9 1.5 -1.6 -1.1 -1.8 0.5
Intelligence (Savage-Jansen 2018) 0.2 0.5 2.1 0.3 0.0 -0.4 -0.1 0.5 -0.7 -1.4
Neuroticism (Nagel 2018) 0.8 1.8 5.8 0.5 -1.4 0.4 -2.4 -0.7 -0.3 2.0
Schizophrenia (2018) 0.8 1.6 4.0 -2.0 1.4 0.9 -1.4 -1.3 -0.4 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 1.7 -0.5 0.8 0.3 -1.3 -0.3 0.0 -0.0
Worry (Nagel 2018) 0.9 1.9 5.6 1.6 -0.6 0.3 -1.7 -1.0 -1.0 2.4
Alzheimer’s Disease (in mother) 2.0 2.4 5.7 -0.2 -0.2 -1.5 0.9 1.5 2.4 -2.4
Alzheimer’s Disease (in father) 0.6 0.6 2.1 0.3 1.4 -0.2 0.2 0.2 0.6 -1.2
Alzheimer’s Disease (including proxy) 1.1 1.5 5.0 0.8 1.1 -0.4 0.7 0.4 1.8 -2.2
Crohns Disease (2017) 0.3 0.6 1.3 -0.5 1.2 0.4 1.1 0.2 0.4 1.0
Irritable Bowel Disease (IBD) 0.3 0.8 2.3 -0.5 0.8 0.3 1.3 0.4 0.7 1.5
Ulcerative Colitis (UC) 0.2 0.4 1.1 0.0 0.3 0.0 0.9 0.5 0.6 1.1
Major Depression (MDD) 3.1 3.8 8.7 -3.0 -2.6 -2.1 -0.7 1.1 0.2 -2.2
Reaction Time 0.4 0.7 2.0 -1.1 -0.2 -0.6 -1.4 -1.1 0.4 -0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.4 0.9 0.5 -1.0 -0.8 -0.4 0.3 -0.7 -0.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.1 1.5 8.4 -0.2 -0.6 0.3 -0.9 -0.0 -2.9 -0.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 1.1 0.4 0.4 0.7 0.8 -0.5 -0.6 1.1
Bipolar Disorder (2011) 0.4 0.4 1.3 -0.4 1.0 1.1 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 1.9 6.8 -2.6 -0.1 -1.6 -0.8 0.3 0.6 -1.6
Coronary Artery Disease (CAD) 1.5 1.8 9.2 -0.7 3.0 1.1 0.2 0.0 1.1 0.3
Crohns Disease (2012) 0.2 0.3 1.3 -0.2 0.7 -0.0 0.1 0.5 0.3 1.1
Mean Putamen Volume 0.9 1.0 2.8 -1.5 -0.2 -0.0 -1.7 1.3 0.1 -0.5
Fasting Glucose 0.6 0.7 3.4 -0.3 -0.1 -0.6 -1.9 0.6 -0.7 -0.3
HbA1C 0.6 0.6 1.6 0.3 0.2 -0.8 0.7 0.8 1.2 -1.1
HDL Cholesterol 0.6 0.9 3.9 -0.3 -0.7 2.0 0.0 -0.7 -0.1 -1.3
LDL Cholesterol 0.5 0.7 2.5 -0.2 1.1 -0.3 0.3 0.2 1.6 -1.1
Lupus 1.5 2.3 5.1 1.5 -0.6 2.2 2.2 -1.4 -1.0 0.7
Neuroticism (2016) 0.8 1.2 3.0 0.2 -0.7 1.2 -1.7 0.6 0.5 1.7
Primary Biliary Cirrhosis 1.5 2.2 5.1 -1.2 2.2 0.7 -1.5 -0.1 1.8 1.7
Rheumatoid Arthritis 0.8 1.1 2.9 -1.1 -0.5 0.6 1.7 -0.1 1.6 0.1
Schizophrenia (2014) 0.6 1.4 2.5 -1.6 1.3 1.6 -1.4 -0.9 0.2 -0.3
Triglycerides 0.8 1.4 4.0 1.0 0.9 -0.8 2.0 -1.3 -0.7 0.9
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.3 -0.8 -0.7 -1.2 1.5 -0.9 0.6 -1.3
Ulcerative Colitis 0.1 0.2 0.7 0.1 -0.2 0.6 0.5 -0.1 0.1 0.8
Blood Eosinophil Count 0.1 0.5 1.7 -0.2 0.8 -0.4 0.7 1.3 0.0 0.9
Blood Platelet Count 0.2 2.8 6.4 1.1 1.3 0.9 -0.6 2.1 2.1 2.5
Blood Red Count 0.5 5.0 10.4 1.9 2.8 0.1 0.8 2.2 2.9 3.2
Blood White Count 0.8 6.0 19.5 1.4 1.8 1.7 -1.9 4.4 2.5 2.2
Heel T-Score 0.1 0.7 2.3 -0.5 1.5 1.2 0.0 0.0 0.8 0.2
BMI 0.2 1.3 3.0 -1.3 -1.4 -0.7 -1.7 0.8 -1.2 0.0
Height 0.1 1.6 3.0 1.0 -0.2 -1.7 1.2 -1.6 -0.8 1.7
Waist Hip Ratio (WHR) 0.7 3.1 9.1 2.1 1.9 1.3 -3.0 0.7 0.8 1.3
Systolic Blood Pressure 0.3 1.5 3.3 -0.6 -1.5 0.5 -1.7 1.8 -0.8 -0.7
Smoking Status 0.5 1.3 4.0 0.5 -1.4 1.7 0.1 0.5 0.1 2.0
Allergy or Eczema 1.6 4.2 12.6 -0.9 -3.5 -0.6 -0.1 -0.9 -1.5 -3.5
Cardiovascular Disease 0.7 2.5 8.0 -0.4 -2.8 0.4 -2.3 1.5 -0.8 0.8
Hypothyroidism (self reported) 0.3 0.7 2.8 -0.2 -0.2 1.7 -0.8 1.0 -0.5 0.3
Respiratory disease 0.2 0.5 1.2 0.2 -1.1 -0.8 -1.1 -0.2 0.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.5 0.7 1.6 0.4 -0.9 0.7 1.9 1.1
Lung FEV1/FVC ratio 3.4 17.2 50.6 -3.2 2.2 1.8 5.6 -7.1 4.1 1.9
Lung FVC 0.3 1.5 5.5 0.6 -1.2 0.1 0.5 2.3 1.0 -1.3
Neuroticism 0.8 2.0 10.6 0.5 -1.2 0.7 -3.2 0.4 -0.1 1.2
Chronotype (morning person) 0.3 0.7 2.6 0.0 -0.5 -1.6 -0.6 1.3 -0.4 0.1
Hair Pigment 0.1 1.8 3.1 0.7 -1.6 1.1 1.8 1.1 1.3 -1.6
Tanning 0.2 2.0 7.2 -1.6 1.5 -2.7 0.6 0.8 0.2 -1.0
Hand grip strength (left) 0.3 0.7 1.7 0.7 0.1 1.2 1.0 -1.3 -0.3 0.2
Number of treatments/medications taken 0.5 1.0 3.8 -0.5 -0.7 -0.4 -0.0 2.0 1.3 -0.5
Average weekly spirits intake 0.2 0.3 0.7 -0.6 -0.4 -0.4 -0.6 -0.1 0.2 0.8
Sensitivity / hurt feelings 1.1 1.9 7.8 -1.7 -0.9 -0.6 -2.8 1.3 0.2 -0.2
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.4 0.3 -1.4 1.2 -0.7 -0.2 -1.6 0.2
Hearing difficulty/problems: Yes 0.6 0.9 3.1 -1.4 0.4 0.5 -0.1 -1.8 0.4 0.9
Relative age of first facial hair 0.5 1.0 2.4 0.7 1.0 -0.8 -1.4 -0.3 -1.6 0.8
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 3.5 -0.7 1.3 -0.6 -0.4 1.9 1.6 -1.0
Ever used hormone-replacement therapy (HRT) 0.5 0.7 3.0 0.3 -0.4 -0.2 -0.2 -1.7 0.1 1.1
Ever had hysterectomy (womb removed) 0.3 0.4 1.5 0.5 0.2 0.1 -0.1 -0.2 0.9 1.2
Systolic blood pressure, automated reading 0.2 0.6 1.8 -0.4 -0.5 0.4 -1.4 1.1 -0.7 -0.6
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.0 -0.1 -1.1 -0.3 0.3 0.5 1.4 1.7
Angina 0.7 0.9 2.1 -0.8 1.4 0.2 -0.4 0.6 1.4 -1.0
Medication for hormone replacement therapy 1.1 1.2 2.9 1.0 -1.7 0.2 1.3 -1.6 0.0 0.6
Vitamin and mineral supplements 0.2 0.3 0.8 -0.6 0.2 -0.8 -0.5 0.4 0.9 -0.3
Supplements: Zinc 1.2 1.3 4.7 0.2 1.1 1.3 0.9 -0.5 0.6 2.2
Medication: Co-codamol 1.2 1.3 5.6 0.3 -2.4 0.7 -0.0 1.3 0.7 -1.0
Medication: Metformin 0.6 0.9 3.1 -0.0 1.2 -0.1 -0.8 0.7 1.8 0.8
Diabetes (father) 1.4 1.7 8.9 -0.4 -0.2 0.4 -0.5 3.0 1.5 0.3
Diabetes (mother) 0.5 0.6 1.3 0.9 -0.7 -1.1 -0.1 1.0 -0.9 0.0
Severe depression (siblings) 1.4 1.5 4.1 0.3 -1.6 1.6 -0.1 -1.2 0.0 2.0
Pack years adult smoking proportion 1.0 1.5 5.9 -0.7 -0.1 -0.3 -0.9 2.4 0.0 -1.7
Impedance of leg (right) 0.3 1.5 5.5 0.5 1.9 2.3 0.1 -0.9 0.8 0.1
Leg fat-free mass (left) 0.2 0.9 3.3 0.3 -0.3 -1.6 0.1 0.1 0.0 1.8
Trunk fat percentage 0.5 2.0 3.8 -0.6 1.9 -1.9 -1.7 1.2 1.3 0.8
Hand grip strength (right) 0.4 1.2 3.2 0.9 0.2 0.3 1.4 -1.8 -1.2 0.8
Townsend deprivation index at recruitment 0.6 0.9 2.5 1.6 -0.2 0.8 1.2 -0.5 -1.2 0.0
Current tobacco smoking 0.3 0.5 1.3 -0.2 -0.6 1.1 -0.4 0.9 0.4 0.8
Average weekly fortified wine intake 0.7 0.9 2.8 0.1 -0.2 1.7 -1.0 -0.5 -1.2 0.8
Maternal smoking around birth 0.7 1.0 2.5 0.8 -1.6 -1.0 -0.4 0.5 -1.4 -0.9
Fed-up feelings 0.9 1.6 3.8 -0.9 -1.9 1.3 -1.8 0.5 -0.4 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 0.0 -0.5 1.2 -1.3 -0.9 -0.6 1.1
Relative age voice broke 0.5 0.8 1.5 0.2 -0.2 -1.1 1.2 -1.1 -1.1 0.5
Taking other prescription medications 0.5 0.8 4.6 0.2 -0.0 -0.1 -0.8 2.1 0.4 0.0
Age when periods started (menarche) 0.6 1.5 4.9 0.8 -1.0 1.8 0.9 -0.2 0.1 2.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.5 -1.6 -0.7 -0.9 0.4 -1.3 -0.7 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.3 1.8 -0.2 0.6 -0.4 0.2 -0.3 1.3 0.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.6 0.1 -0.9 0.3 -1.6 -0.3 -0.3 -0.2
Qualifications: CSEs or equivalent 1.5 1.9 5.3 1.2 1.2 -1.4 0.8 2.3 1.2 1.1
Serious illness, injury or assault to yourself 0.9 1.1 4.7 -0.5 0.1 0.6 -2.2 0.3 -1.4 -0.4
High blood pressure 1.4 3.9 8.2 -1.9 -2.9 -2.2 -2.2 2.0 -0.7 -1.2
Hayfever, allergic rhinitis or eczema 1.2 2.7 8.6 0.0 -2.9 -0.0 -0.2 -0.9 -1.4 -2.7
Multivitamins +/- minerals 1.7 2.1 3.4 1.5 -0.8 0.5 1.8 -1.6 -1.8 1.6
Stomach or abdominal pain in last month 1.1 1.3 3.7 -0.1 -0.5 1.7 -0.8 -0.6 -1.2 1.9
Supplements: Glucosamine 1.2 1.6 4.2 0.6 0.9 2.0 1.3 -1.9 0.0 0.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.0 0.6 1.2 0.5 -0.1 -1.4 -0.8 1.1
Medication: Atenolol 1.1 1.4 2.9 -1.7 -1.3 -1.0 -0.9 1.1 1.1 -1.0
Medication: Levothyroxine sodium 0.4 0.7 2.7 -0.7 -1.6 1.2 -0.4 0.3 -0.2 0.5
Sitting height 0.2 1.3 3.3 0.3 0.1 -1.0 1.8 -1.5 0.4 1.5
Chronic bronchitis/emphysema (father) 2.0 2.4 8.1 1.2 -0.5 0.5 1.4 -2.8 -1.4 1.6
High blood pressure (mother) 1.9 2.6 8.0 -1.0 -2.2 -0.6 -0.8 2.8 1.5 -1.3
Body mass index (BMI) 0.2 1.0 2.8 -0.9 0.1 -1.4 -1.1 1.7 0.5 0.4
Impedance of leg (left) 0.1 0.7 2.0 0.4 1.3 1.4 -0.1 -0.8 0.6 -0.3
Leg predicted mass (left) 0.2 0.8 3.2 0.3 -0.4 -1.6 0.2 0.1 -0.1 1.8
Trunk fat mass 0.4 1.6 3.6 -0.2 1.6 -1.9 -1.3 0.8 1.0 1.3
Waist circumference 0.5 1.7 4.7 -0.2 1.4 -1.4 -2.2 1.3 0.7 1.0
Number of incorrect matches in round 0.5 0.9 2.8 0.2 0.7 0.0 1.7 -0.1 1.5 -0.9
Past tobacco smoking 0.1 0.2 0.6 0.6 0.8 -0.2 -0.2 0.2 0.2 -0.8
Alcohol usually taken with meals 0.3 0.4 1.1 0.1 0.2 -1.1 0.2 -0.2 -0.7 1.1
Nervous feelings 1.3 2.4 8.9 1.9 0.6 1.6 -1.1 -0.2 -0.5 3.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 3.1 0.8 -0.7 1.7 -1.1 -0.7 -0.7 1.7
Hearing difficulty/problems with background noise 0.7 1.2 3.0 -0.5 0.9 1.5 -1.0 0.3 1.7 0.9
Hair/balding pattern: Pattern 2 1.7 2.2 7.8 1.0 -1.7 1.2 0.1 -0.4 -2.8 -1.3
Had menopause 0.8 1.0 3.2 -0.7 0.2 -1.2 -1.0 -0.1 1.8 -0.8
Had other major operations 0.4 0.5 1.3 -0.6 -1.1 -1.1 0.6 0.3 -0.1 -0.5
Forced vital capacity (FVC) 0.3 1.0 2.3 1.5 -0.8 0.9 1.5 -0.4 0.3 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.5 -0.7 -0.3 -0.6 -0.3 0.2 0.5 -0.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 -0.7 -1.0 -0.8 -0.6 -0.3 -0.6 -0.7
Qualifications: None of the above 0.5 1.0 2.7 -0.9 -0.5 1.1 -0.4 -1.2 1.6 -0.6
Financial difficulties in last 2 years 0.6 0.8 2.6 1.6 0.4 -1.3 0.2 0.1 0.0 1.1
Mouth/teeth dental problems 0.3 0.4 1.3 -0.1 -0.6 -0.4 0.6 0.8 -1.1 -0.0
Heart attack 0.6 0.8 2.7 0.0 0.7 0.5 0.5 1.2 1.6 -0.5
Allergy 0.4 0.9 3.1 -0.9 1.8 0.3 0.4 1.0 1.1 0.6
Pain all over the body in last month 0.4 0.5 1.5 0.0 -0.5 0.3 0.4 0.7 -1.2 -0.9
Diabetes (self-reported) 0.7 1.0 3.9 -0.8 -0.3 -0.1 -1.3 0.9 2.0 0.1
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 7.0 0.7 -2.6 0.8 0.5 -0.9 -2.6 -0.9
Medication: Ramipril 0.2 0.2 0.5 -0.4 -0.7 -0.5 -0.7 0.2 -0.4 -0.2
Medication: Simvastatin 0.3 0.4 1.8 -1.4 -0.7 -0.5 -0.5 0.0 -0.3 -0.3
Fluid intelligence score 0.2 0.5 1.0 0.8 -0.7 -0.9 -0.3 0.5 -1.0 0.6
Illnesses of siblings 0.6 0.8 1.7 -0.3 1.3 1.2 0.3 0.2 0.8 -1.2
Neuroticism score 0.7 1.4 4.5 0.4 -1.1 0.2 -2.1 0.2 -0.5 1.9
Weight 0.2 0.9 2.9 -0.0 0.6 -1.7 -0.2 0.4 0.6 1.7
Impedance of arm (right) 0.3 1.2 4.6 1.2 2.1 0.2 -0.6 0.3 1.3 -0.4
Arm fat percentage (right) 0.5 1.9 3.6 -0.3 1.6 -1.7 -1.6 1.9 1.2 0.4
Trunk fat-free mass 0.2 0.9 4.3 0.9 -0.3 -0.8 0.7 -0.4 -0.1 2.1
Hip circumference 0.2 1.0 3.0 -0.9 0.9 -1.7 -0.3 0.8 1.2 0.7
Time employed in main current job 0.3 0.3 1.2 -0.3 1.0 -0.2 0.0 -1.1 0.3 0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.1 0.9 -0.1 -1.0 0.2 0.9 -0.8 -1.1
Father’s age at death 1.9 2.5 7.2 1.1 -2.7 -1.2 -1.6 0.0 -1.8 -1.3
Worrier / anxious feelings 0.7 1.4 3.1 -0.1 -1.8 -0.9 -0.9 1.1 1.3 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 5.1 0.6 -2.1 1.7 -1.3 -1.6 -2.3 1.2
Falls in the last year 0.8 1.1 2.7 -0.1 -1.0 -1.3 -1.2 -0.9 -1.6 -0.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.4 -1.5 0.7 -0.1 -0.2 -1.4 -0.2 -0.3
Number of live births 0.8 1.1 3.0 -0.8 0.7 0.1 1.4 0.7 1.7 -1.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 7.8 0.3 -0.1 1.0 2.8 -2.1 1.1 1.7
Pulse rate 0.2 0.4 2.2 -0.3 0.5 0.1 -0.1 -1.5 0.5 0.3
Happiness 0.4 0.5 1.2 0.4 -0.8 0.3 1.1 -0.2 0.9 -0.8
Noisy workplace 0.9 1.1 3.5 0.6 -1.9 1.4 0.2 1.3 0.2 0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.0 0.5 -1.4 -0.4 1.1 -2.0 -1.3 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.7 -0.5 0.5 1.1 -1.6 0.2 0.2 0.5
Mouth/teeth dental problems: Dentures 0.7 1.2 5.2 -0.5 0.7 1.3 0.0 -0.8 2.3 0.0
Asthma 0.2 0.4 1.5 0.6 -1.2 -0.8 -0.1 0.1 0.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.5 -0.3 0.3 0.2 0.1 0.4 0.0
Medication: Cholesterol lowering 0.4 0.6 1.8 -0.2 -1.0 -0.8 -0.6 1.4 0.2 -0.2
Depression (self-reported) 0.9 1.0 3.2 0.7 0.2 0.8 -1.1 -0.5 -1.2 1.8
Medication: Lansoprazole 1.1 1.3 6.0 -0.5 0.7 0.6 -2.5 0.6 -1.0 -0.5
Prospective memory result 1.2 1.4 3.5 0.5 0.5 -1.0 -1.3 1.9 -0.4 -1.8
Lung cancer (father) 1.5 1.8 3.4 0.8 -0.9 1.9 0.4 1.8 -1.3 1.6
Illnesses of mother 2.1 2.5 10.3 0.3 1.0 1.3 0.8 -3.2 -1.3 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.5 10.9 0.5 0.7 1.3 3.3 -3.2 1.5 2.3
Pulse wave Arterial Stiffness index 0.7 0.8 1.6 -1.0 -0.0 1.2 -0.6 1.0 1.3 0.3
Impedance of arm (left) 0.3 1.6 6.2 1.4 2.5 -0.2 -0.4 -0.7 1.5 0.3
Arm fat mass (right) 0.3 1.3 3.4 -0.2 0.9 -1.8 -1.1 1.5 0.8 0.7
Trunk predicted mass 0.2 0.9 4.3 0.9 -0.3 -0.8 0.5 -0.3 -0.1 2.1
Standing height 0.3 3.4 9.1 2.0 1.5 -0.7 1.5 -2.4 0.4 3.0
Length of working week for main job 0.2 0.3 0.6 0.2 0.8 0.7 0.5 -0.6 -0.1 0.3
Exposure to tobacco smoke at home 0.5 0.6 1.5 -0.7 -0.5 0.1 -1.0 0.6 0.7 -1.2
Breastfed as a baby 1.8 2.2 8.6 -1.2 1.0 -1.5 0.7 1.3 2.9 -0.3
Tense / ‘highly strung’ 0.8 1.3 6.8 2.6 -0.4 0.6 -0.4 -0.5 -0.1 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.7 0.8 -2.2 -0.2 -0.2 -0.3 -1.5 0.9
Hair/balding pattern: Pattern 4 0.2 0.4 1.7 -0.3 0.9 -0.4 0.2 0.4 1.3 -0.3
Birth weight of first child 0.2 0.4 0.9 -0.9 0.5 -0.7 -0.5 -0.5 -0.7 -0.5
Peak expiratory flow (PEF) 0.7 1.7 5.3 0.1 0.6 -0.6 1.6 -2.3 0.4 1.8
Pulse wave reflection index 0.7 0.8 3.2 0.1 -1.8 -0.1 -0.0 0.8 -0.1 1.4
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.7 0.3 0.9 -1.5 0.1 -0.4 0.9 2.2
Loud music exposure frequency 0.2 0.2 1.1 0.2 -0.1 -0.2 -0.2 -1.1 0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.3 1.8 -1.4 0.8 0.7 -0.8 -1.0 0.9
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.0 -0.4 -1.1 -0.4 -0.6 -1.3 -0.2 1.7
Blood clot in the leg (DVT) 1.6 2.1 6.1 1.8 -0.3 1.9 -0.2 -0.3 -1.2 2.5
Medication: Paracetamol 0.7 1.2 3.6 -1.9 -0.6 -1.2 -0.0 -0.4 1.6 -0.9
Headache pain in last month 1.1 1.9 5.2 1.1 -2.3 1.8 -0.1 -0.9 -0.9 1.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.6 4.7 0.8 2.2 1.3 1.0 -1.7 0.0 -0.1
Glaucoma (self-reported) 0.3 0.3 0.6 -0.6 0.7 -0.1 0.4 -0.4 0.7 -0.8
Gout (self-reported) 2.2 3.0 6.7 -1.4 -1.1 -1.6 -1.2 2.6 0.5 -2.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.0 -1.0 -0.8 1.0 -0.6 0.9 -0.4 -0.0
Medication: Amlodipine 0.8 1.1 4.5 1.1 -2.1 -0.0 0.0 -1.2 -0.6 0.5
Medication: Ventolin 100micrograms inhaler 1.9 2.5 7.4 -0.4 -2.7 -0.8 -2.2 1.8 -0.6 -0.8
Birth weight 0.7 1.6 3.1 1.0 -1.4 1.1 1.8 -1.4 1.0 1.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.8 0.5 -0.9 -1.2 0.2 1.3 -0.7 -0.7
High blood pressure (siblings) 0.9 1.3 3.7 1.1 -1.5 -0.7 0.8 -0.9 -0.1 1.9
Forced vital capacity (FVC), Best measure 0.5 1.8 4.3 1.2 -0.2 0.9 2.1 -1.4 0.8 1.8
Body fat percentage 0.5 1.8 3.1 -0.6 1.8 -1.6 -1.7 1.3 1.1 1.0
Leg fat percentage (right) 0.4 1.4 3.1 -0.8 1.6 -0.3 -1.8 1.3 0.9 0.6
Arm fat-free mass (right) 0.2 0.9 3.8 -0.0 -0.5 -1.2 0.5 -0.7 -0.2 2.0
Exposure to tobacco smoke outside home 0.4 0.6 2.2 1.5 -0.7 -0.0 0.6 -0.4 -0.6 0.7
Comparative body size at age 10 0.4 1.0 3.5 -1.2 -0.1 -0.8 0.0 -1.9 0.3 -1.2
Number of full brothers 0.7 0.9 4.3 -0.8 0.0 0.2 0.9 -0.4 2.1 0.4
Worry too long after embarrassment 0.4 0.7 2.3 -0.5 -1.5 0.2 -0.8 -0.6 0.5 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 3.6 1.2 -1.3 1.3 -1.7 -0.3 -1.9 1.4
Wheeze or whistling in the chest in last year 0.3 0.5 2.1 -0.2 -0.0 -0.0 -1.5 0.5 0.9 -0.7
Number of children fathered 0.1 0.1 0.2 -0.0 -0.2 0.5 -0.2 0.5 -0.0 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.6 0.5 -1.3 -0.5 0.7 0.0 0.1 -0.3
Age at first live birth 1.0 1.8 5.1 1.1 2.3 -1.3 0.0 -1.3 -0.9 1.4
Pulse wave peak to peak time 0.8 0.9 1.9 0.9 -0.1 -1.2 0.8 -1.1 -1.4 -0.3
Health satisfaction 0.8 1.0 2.4 0.4 0.7 0.4 -1.3 1.4 -0.6 -1.5
Shortness of breath walking on level ground 0.8 1.0 3.1 -0.9 -0.2 -0.6 -1.8 1.2 -0.2 -1.1
Qualifications: College or University degree 0.3 0.9 2.3 0.6 1.5 -1.1 -0.6 -0.8 -0.9 0.7
Eye problems/disorders: None of the above 0.4 0.4 1.3 0.3 0.9 0.8 -0.3 0.3 -1.1 -0.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.1 0.2 -1.0 1.5 0.6 0.1 0.2 0.1
Emphysema/chronic bronchitis 1.0 1.1 2.6 -0.2 1.2 -0.4 -1.6 1.2 1.4 0.1
Medication for pain relief, constipation, heartburn 0.9 1.6 4.6 1.5 0.1 -0.2 0.8 -1.4 -2.2 1.2
Neck or shoulder pain in last month 0.2 0.3 1.1 -0.2 -0.1 0.4 -0.7 0.4 1.1 -0.0
Medication: Blood pressure 1.2 2.0 5.9 -0.7 -2.4 -2.0 -0.5 1.5 0.2 -1.0
Angina (self-reported) 0.6 0.7 2.2 -0.6 1.1 0.3 -0.3 0.8 1.5 -0.8
Migraine (self-reported) 0.1 0.1 0.2 0.4 -0.3 0.2 0.1 0.4 -0.2 -0.0
Medication: Ibuprofen 0.2 0.2 0.4 0.3 -0.6 0.6 0.4 0.0 -0.3 0.7
Medication: Allopurinol 2.4 3.2 9.0 -0.4 -0.2 -1.6 -1.6 2.6 1.0 -3.0
Medication: Omeprazole 1.0 1.2 4.4 -0.7 1.3 -0.1 0.0 2.1 0.9 -1.2
Medication: Seretide 50 evohaler 0.9 1.1 3.9 0.9 -0.3 -1.6 2.0 -0.0 -0.2 -0.6
Mean time to correctly identify matches 0.4 0.7 2.5 -1.1 -0.4 -1.6 -0.7 -0.2 0.1 -0.9
Heart disease (mother) 0.5 0.7 2.8 -0.3 1.7 -0.1 0.1 1.0 0.8 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.4 -0.8 -1.6 -0.6 -0.0 0.7 -1.2 -0.7
Whole body fat mass 0.3 1.4 3.0 -0.3 1.4 -1.7 -1.1 0.8 0.8 1.4
Leg fat mass (right) 0.3 1.1 1.9 -0.9 1.0 -0.9 -1.4 1.3 0.8 0.8
Arm predicted mass (right) 0.2 0.8 3.5 -0.3 -0.4 -1.2 0.3 -0.4 -0.3 1.9
Pulse rate, automated reading 0.1 0.4 1.2 -0.5 -0.7 0.3 -0.4 -0.7 -0.5 1.1
Alcohol intake frequency. 0.3 0.7 2.1 0.5 -0.6 -1.1 0.4 1.0 -0.3 -1.4
Comparative height size at age 10 0.4 2.0 4.1 0.7 1.1 -0.8 2.0 -2.0 -0.7 1.8
Number of full sisters 1.6 1.9 4.1 -0.9 -1.7 -1.8 -0.6 2.0 0.4 -1.4
Suffer from ‘nerves’ 1.0 1.6 5.1 2.1 -0.2 0.7 -0.5 -0.7 -0.5 2.3
Overall health rating 0.8 1.8 8.7 -0.2 0.9 -0.1 -2.9 1.4 0.8 -0.6
Chest pain or discomfort 0.2 0.3 0.7 0.8 0.4 -0.3 -0.4 0.5 -0.8 -0.3
Had major operations 1.4 1.7 4.1 -1.0 -2.0 -1.5 -0.8 1.4 -0.8 1.1
Age at last live birth 1.6 2.3 4.8 2.2 1.8 -1.6 1.3 -1.1 0.8 1.4
Family relationship satisfaction 1.6 1.9 4.7 1.5 0.3 -1.8 -1.0 1.2 -2.2 -0.8
Leg pain on walking 1.0 1.2 4.1 -0.1 0.4 -2.0 -1.3 0.7 -0.3 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.2 -0.7 -0.2 0.3 1.1 1.8 1.5 0.4
Commuting to job workplace: Car/motor vehicle 1.7 1.9 4.4 -1.7 -0.7 -0.2 -1.7 1.5 -0.7 -2.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.9 -0.6 -1.0 -1.0 1.1 1.4 1.2 -0.4
Medication: Aspirin 0.3 0.4 1.0 0.2 0.6 0.6 0.0 1.0 0.7 -0.3
Supplements: Vitamin C 1.2 1.4 4.1 -1.4 2.0 0.5 -0.5 0.9 1.6 -0.0
Knee pain experienced in last month 0.7 1.1 1.6 -1.0 -1.3 1.3 0.8 0.8 0.7 -1.2
Hypertension (Self-reported) 1.7 4.7 7.9 -2.1 -2.8 -2.3 -2.8 2.2 -0.3 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 6.4 -0.9 0.2 -1.1 -2.5 2.0 0.0 -1.5
Illnesses of father: Heart disease 1.2 1.7 7.2 -2.7 1.8 -0.6 0.1 0.2 0.8 0.5
Illnesses of siblings: Diabetes 1.0 1.2 2.8 -1.6 0.1 -0.9 0.5 0.9 1.7 1.2
Smoking status: Previous 0.1 0.2 0.7 -0.2 -0.8 0.6 -0.1 0.2 0.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 9.5 1.1 0.5 0.8 0.3 -1.4 -0.6 3.1
Whole body fat-free mass 0.2 1.0 4.3 0.5 -0.5 -1.2 0.6 -0.3 -0.1 2.1
Leg fat-free mass (right) 0.2 1.1 3.7 0.2 -0.7 -1.9 0.3 0.1 0.0 1.8
Arm fat percentage (left) 0.5 2.0 3.6 -0.3 1.6 -1.9 -1.7 1.6 1.4 0.7
Average weekly red wine intake 0.4 0.6 1.8 0.6 0.6 -0.2 1.4 -0.8 0.3 0.8
Handedness (chirality/laterality): Left-handed 1.5 1.7 6.5 -0.4 -1.6 1.3 2.5 -0.6 -0.5 0.9
Mood swings 0.5 1.0 2.6 0.3 -1.6 1.2 -1.0 -0.7 -0.8 0.7
Loneliness, isolation 0.6 0.8 3.1 0.4 0.7 -0.5 -1.7 0.9 0.3 1.0
Long-standing illness, disability or infirmity 1.3 2.0 6.5 -0.5 -0.2 0.1 -2.5 2.1 0.4 -1.8
Ever had bowel cancer screening 1.1 1.3 4.1 0.3 0.0 2.0 -1.5 -0.1 -0.1 -1.6
Diabetes diagnosed by doctor 0.4 0.7 3.1 -0.4 0.6 -0.3 -0.9 0.7 1.8 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.4 0.7 0.1 -0.0 -0.0 0.7 0.3
Friendships satisfaction 1.4 1.8 5.7 -0.4 -0.1 -0.2 -2.4 -0.1 -1.8 -1.8
Qualifications: nursing, teaching 0.3 0.4 1.3 0.8 0.2 -1.1 -0.8 0.4 -0.1 -0.5
Commuting to job workplace: Walk 1.4 1.5 6.0 -0.4 0.9 -0.7 1.5 -0.3 2.5 0.9
Eye problems/disorders: Cataract 0.6 0.7 1.8 -1.0 -0.5 -0.6 -0.4 1.1 1.4 0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.0 0.1 0.6 -0.9 -0.1 -0.8 -0.2 -1.0
Medication for cholesterol 0.2 0.3 1.0 0.5 1.0 0.1 0.2 -0.5 0.4 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 7.4 0.8 -0.2 0.8 2.4 -2.7 -0.5 1.0
Back pain experienced in last month 0.6 0.9 2.2 0.4 -1.0 1.5 -0.7 0.7 1.4 -0.5
Mineral and other dietary supplements 0.8 1.0 4.4 -0.6 -1.1 -2.1 0.9 0.1 0.3 -0.5
Breast cancer (self-reported) 0.9 1.1 2.9 -0.7 -0.2 0.0 -0.3 -1.4 -1.5 1.7
Asthma (self-reported) 0.2 0.3 1.0 0.8 -1.0 -0.5 0.2 -0.0 0.6 0.2
Osteoporosis (self-reported) 0.7 0.8 2.8 -0.8 0.1 0.1 0.3 1.0 1.7 -1.2
Osteoarthritis (self-reported) 0.6 0.8 1.8 -0.5 -1.3 1.0 -0.1 1.0 0.2 -1.2
Medication: Aspirin 0.1 0.1 0.2 0.2 -0.1 0.5 0.1 0.3 0.4 -0.3
Medication: Gliclazide 0.4 0.4 1.3 1.1 -0.4 0.6 0.1 0.6 -0.6 0.7
Illnesses of father: None of the above (group 1) 0.5 0.6 3.1 1.8 0.2 -0.1 0.7 0.5 0.6 -0.3
Smoking status: Current 0.2 0.4 1.1 -0.3 -0.3 1.1 -0.3 0.6 0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.6 0.7 -0.1 -0.3 1.9 -1.5 0.8 0.1
Whole body water mass 0.2 0.9 4.2 0.3 -0.4 -1.1 0.5 -0.2 -0.1 2.0
Leg predicted mass (right) 0.2 1.1 4.0 0.2 -0.5 -2.0 0.2 0.1 0.0 1.8
Arm fat mass (left) 0.3 1.2 2.9 -0.0 1.0 -1.7 -0.9 1.3 0.9 1.2
Number of self-reported non-cancer illnesses 2.1 3.6 7.5 -1.3 -2.3 -0.9 -2.7 2.7 -0.9 -1.3
Average weekly champagne plus white wine intake 0.9 1.2 3.8 -0.4 -0.7 -1.6 -1.9 0.8 -0.7 -0.2
Miserableness 0.6 1.0 2.1 -0.5 -1.0 1.2 -0.8 -1.1 0.2 1.5
Guilty feelings 0.7 1.0 5.0 -0.4 -1.2 0.4 -2.2 0.5 -0.3 -0.5
Wears glasses or contact lenses 0.5 0.5 1.2 -0.6 1.1 0.7 0.4 -0.1 1.1 0.4
Ever taken oral contraceptive pill 0.8 0.8 2.7 0.3 -0.5 0.2 0.8 -0.9 -1.2 1.6
Hearing aid user 1.6 1.9 5.3 -1.9 -0.8 -0.3 -2.3 1.0 -1.2 -1.0
Mother’s age at death 0.7 0.9 4.2 2.1 -1.0 -0.5 0.3 -0.4 -0.7 0.2
Financial situation satisfaction 0.7 0.9 3.9 -0.6 -2.0 -0.6 -0.2 0.1 -0.8 -1.1
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.4 1.2 -1.0 1.4 -0.3 -0.7 -1.6 -0.4
Commuting to job workplace: Public transport 0.7 0.8 2.4 1.6 -0.3 -0.3 0.0 -1.1 -0.8 1.1
Eye problems/disorders: Glaucoma 0.3 0.4 1.0 -0.8 0.6 1.0 0.1 -0.9 -0.0 -0.0
Medication: Blood pressure 0.9 1.7 4.6 -1.4 -1.5 -0.0 -2.2 1.2 -0.4 -1.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 0.9 -1.1 0.1 0.4 0.6 0.7 -0.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.5 1.1 0.3 1.6 -0.4 0.9 0.4 0.2
High cholesterol (Self-reported) 1.0 1.8 4.7 -1.2 -2.2 -0.4 -1.7 1.2 -1.1 -0.8
Medication: Bendroflumethiazide 2.6 4.0 6.6 -1.4 -1.3 -2.6 -2.5 2.2 0.2 -2.5
Medication: Paracetamol 0.9 1.4 3.8 -1.9 -0.3 -0.7 0.7 -1.2 1.7 -0.7
Medication: Lisinopril 1.8 2.3 5.2 -0.5 -1.0 -0.8 -2.3 2.3 -0.6 -1.9
Medication: Atorvastatin 0.9 1.1 3.7 -0.3 -1.9 0.3 -0.1 1.7 0.5 -0.8
Illnesses of father: High blood pressure 0.7 0.9 2.0 -0.8 -1.4 0.9 -1.0 -0.3 -1.1 0.9
Alcohol drinker status: Never 1.7 2.0 8.5 0.5 -0.5 2.9 1.1 -0.1 1.5 1.2
Ever smoked 0.5 0.9 1.6 -0.6 -0.9 -0.1 1.1 -1.2 -0.8 1.2
Basal metabolic rate 0.2 0.9 4.2 0.4 -0.2 -1.3 0.4 0.0 0.0 2.1
Leg fat percentage (left) 0.4 1.4 3.5 -0.9 1.2 -1.0 -1.9 1.5 0.9 0.4
Arm fat-free mass (left) 0.1 0.7 3.0 0.0 -0.4 -1.1 0.5 0.2 -0.2 1.7
Number of operations (self-reported) 1.0 1.5 2.7 -1.3 -1.7 -1.5 -1.2 1.2 -0.2 0.6
Average weekly beer plus cider intake 0.2 0.4 1.1 0.3 -0.8 0.0 1.0 0.3 -0.7 -0.1
Irritability 0.5 0.8 1.6 0.3 0.5 -1.3 -1.0 1.2 0.5 1.2
Risk taking 0.6 0.9 3.2 0.5 -1.0 0.3 1.8 -1.1 -0.4 0.2
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.4 -0.4 -1.4 -1.0 -0.5 1.3 -1.8 -0.5
Fractured/broken bones in last 5 years 0.5 0.6 1.6 -0.7 0.5 0.4 1.3 -0.6 0.5 1.1
Age started oral contraceptive pill 0.8 1.0 1.9 -0.6 0.5 -1.4 -1.2 1.1 0.9 -1.0
Diastolic blood pressure, automated reading 0.8 2.4 10.7 0.4 -3.3 -0.0 -0.2 1.8 -1.7 0.3
Ever depressed for a whole week 0.7 0.9 3.5 -1.1 -1.9 -0.8 -0.4 -0.5 -0.5 0.7
Unable to work because of sickness or disability 0.2 0.2 0.4 0.4 -0.6 0.3 0.5 0.5 0.1 0.6
Commuting to job workplace: Cycle 1.2 1.4 5.0 1.2 -1.2 -0.3 2.2 -0.9 0.4 1.0
Myopia 1.0 1.5 3.9 -1.8 0.8 -1.0 -0.3 0.8 0.9 -2.0
Vascular/heart problems diagnosed by doctor 1.1 3.1 5.5 1.9 2.1 1.5 2.3 -1.9 0.6 1.3
Cholesterol lowering medication 0.8 1.2 2.3 -1.1 1.0 -0.7 0.3 1.5 1.0 -1.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.8 -0.1 1.8 -0.3 -0.5 2.2 -0.0 -1.0
Pain experienced in last month 0.9 1.5 7.4 -0.2 2.7 -0.7 -1.0 -1.0 -0.9 -0.2
Supplements: Calcium 0.3 0.3 0.8 0.0 0.7 -0.9 -0.2 0.7 0.5 0.4
Basal cell carcinoma (self-reported) 1.2 1.4 5.2 0.9 -0.5 1.5 2.3 0.1 -0.4 1.1
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.0 -0.2 0.8 0.1 0.4 1.4 1.7 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 6.1 1.9 0.1 1.8 0.4 -0.7 -0.9 2.5
Heart disease (siblings) 0.4 0.5 1.2 0.1 0.8 -0.6 -1.0 -0.6 -1.1 -0.3
Alcohol drinker status: Previous 1.3 1.5 3.2 1.2 -1.8 -1.3 0.6 -1.2 -1.4 0.6
Pack years of smoking 1.3 2.0 5.9 -0.9 -0.1 -0.6 -0.9 2.4 0.2 -2.4
Impedance of whole body 0.2 1.2 5.2 0.9 2.3 0.5 -0.2 -0.9 1.0 0.1
Leg fat mass (left) 0.3 1.0 1.9 -0.9 0.5 -1.3 -1.3 1.4 0.7 0.7
Arm predicted mass (left) 0.1 0.7 3.3 0.1 -0.4 -1.1 0.5 -0.0 -0.2 1.8