Hub : Genes

LTA4H

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.5069 0.0704 4.7e-10 0.257 NA 0.383 NA 0.433 9.8e-10 NA 8.9e-15 NA 4.6e-17
2 GTEx Brain Caudate basal ganglia 0.2470 0.0870 4.5e-03 0.010 NA -0.010 NA 0.005 1.6e-01 NA 7.9e-01 NA 2.2e-01
3 GTEx Muscle Skeletal 0.1985 0.0437 1.5e-07 0.044 NA 0.082 NA 0.077 3.9e-05 NA 2.1e-08 NA 5.7e-08
4 METSIM Adipose 0.0987 0.0273 1.5e-06 0.044 0.043 0.045 0.043 0.036 3.3e-07 4.8e-07 2.2e-07 4.3e-07 3.6e-06
5 NTR Blood 0.1143 0.0197 9.4e-16 0.057 0.069 0.084 0.078 0.076 6.4e-18 3.1e-21 1.2e-25 6.4e-24 2.5e-23
6 YFS Blood 0.5613 0.0303 0.0e+00 0.299 0.502 0.528 0.522 0.520 8.7e-100 3.0e-193 8.6e-208 2.1e-204 1.9e-203
7 TCGA Breast Invasive Carcinoma 0.0381 0.0135 3.5e-05 0.038 0.022 0.031 NA 0.033 3.0e-08 1.7e-05 4.9e-07 NA 2.2e-07
8 TCGA Glioblastoma Multiforme 0.2130 0.1050 6.4e-03 0.003 -0.002 0.001 NA -0.006 2.5e-01 3.6e-01 3.0e-01 NA 5.5e-01
9 TCGA Prostate Adenocarcinoma 0.0624 0.0281 1.0e-03 0.021 0.008 0.005 NA 0.013 2.5e-03 3.9e-02 9.8e-02 NA 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.5 0.7 2.4 -0.5 0.9 0.2 -1.6 -1.2 -1.2 0.1 -0.5 -0.2
Bipolar Disorder or Schizophrenia 0.3 0.6 3.2 0.1 1.8 -0.5 -1.1 -0.5 -0.5 0.5 -0.3 0.3
Depressed Affect (Nagel 2018) 0.5 1.0 3.1 0.1 0.6 -1.7 -0.4 0.5 0.7 -1.8 -0.0 -1.4
Depression (Nagel 2018) 0.5 0.8 2.1 1.0 1.4 -1.4 0.7 -0.2 0.0 0.1 0.9 0.8
Intelligence (Savage-Jansen 2018) 0.3 1.1 3.0 -1.3 -0.8 1.7 -0.1 -0.0 -0.1 -0.7 -1.7 -0.9
Neuroticism (Nagel 2018) 0.6 1.3 4.3 0.7 0.1 -2.1 0.3 0.5 0.6 -2.0 0.7 -1.3
Schizophrenia (2018) 0.2 0.5 2.5 0.6 1.6 -0.8 -0.1 0.3 0.3 0.5 -0.0 0.6
Schizophrenia vs Biploar Disorder 1.0 1.3 2.8 1.3 1.3 -1.7 0.8 1.0 1.5 -1.1 0.7 -0.3
Worry (Nagel 2018) 0.5 1.1 3.4 1.5 -0.2 -1.3 0.8 0.7 0.9 -0.9 1.8 -0.1
Alzheimer’s Disease (in mother) 1.1 1.3 5.6 1.1 0.6 -0.6 -0.8 1.3 2.4 -1.0 0.7 -0.8
Alzheimer’s Disease (in father) 0.5 0.5 2.0 0.1 0.6 -0.7 -0.6 -1.4 -0.6 0.7 -0.2 0.6
Alzheimer’s Disease (including proxy) 0.4 0.5 1.9 0.9 1.0 -0.8 -0.3 0.1 1.4 -0.3 0.2 -0.2
Crohns Disease (2017) 0.3 0.7 2.2 -0.7 0.1 -1.5 0.6 0.4 0.8 -1.1 0.3 -1.2
Irritable Bowel Disease (IBD) 0.7 1.6 3.9 -1.8 -0.5 -0.3 0.7 1.1 1.4 -1.6 -0.5 -2.0
Ulcerative Colitis (UC) 1.3 2.5 7.2 -2.7 -1.0 1.1 0.7 1.6 1.6 -1.5 -1.2 -2.0
Major Depression (MDD) 0.6 0.8 1.8 0.3 0.9 1.1 -0.2 1.1 1.4 -0.9 -0.7 -0.8
Reaction Time 0.5 1.0 3.5 0.2 -1.0 -0.3 0.1 1.9 1.2 -1.2 0.0 -1.3
Verbal and Numeric Reasoning (VNR) 0.9 2.1 5.0 -1.1 -1.2 2.2 -2.2 -0.3 -0.8 -0.8 -2.1 -0.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.3 0.7 -0.7 0.2 -0.8 -0.0 0.3 -0.1 -0.8 -0.6 -0.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 1.9 -0.5 0.6 0.2 1.4 0.4 0.1 -0.4 0.1 -0.5
Bipolar Disorder (2011) 2.6 2.5 8.7 -3.0 0.5 1.1 -1.6 -0.6 -0.6 -0.5 -2.4 -1.8
Body Mass Index (BMI) (2010) 0.5 0.7 4.8 0.5 -1.0 0.0 -2.2 -0.1 -0.2 0.4 -0.2 0.6
Coronary Artery Disease (CAD) 1.6 1.9 7.9 -2.5 2.8 0.4 -0.0 -0.5 -0.5 -0.1 -1.6 -0.6
Crohns Disease (2012) 0.8 1.3 3.3 -1.4 -1.4 0.0 -1.0 0.2 0.6 -1.6 -0.9 -1.8
Mean Putamen Volume 0.1 0.1 0.6 -0.2 0.4 -0.4 0.0 -0.1 0.0 -0.4 -0.8 -0.1
Fasting Glucose 1.9 2.3 5.3 0.5 -1.5 1.8 -0.7 -2.1 -2.3 1.5 -0.1 1.6
HbA1C 0.7 0.8 4.5 -0.5 0.0 0.3 -2.1 -0.4 -0.9 0.2 -1.1 -0.2
HDL Cholesterol 0.7 1.1 2.5 1.2 1.2 -0.8 1.6 0.6 1.5 0.3 0.9 0.5
LDL Cholesterol 0.2 0.4 1.4 0.7 1.2 -0.4 0.2 -0.4 -0.2 0.7 0.5 0.6
Lupus 1.1 1.7 8.8 0.7 0.7 0.8 3.0 -1.0 -0.3 1.1 0.9 1.2
Neuroticism (2016) 0.4 0.5 1.7 -0.2 -0.3 -0.1 0.5 -0.8 -0.4 1.3 0.7 1.3
Primary Biliary Cirrhosis 0.3 0.4 2.5 -1.6 -0.6 -0.5 -0.6 -0.5 -0.4 0.1 -0.3 0.0
Rheumatoid Arthritis 0.4 0.5 1.6 -0.6 -1.0 -0.5 1.0 -0.1 0.3 0.4 1.3 0.3
Schizophrenia (2014) 0.3 0.7 2.8 -0.6 1.7 0.2 -0.5 -0.7 -0.8 0.8 -0.5 0.7
Triglycerides 0.2 0.3 1.7 0.3 1.3 0.3 -0.6 0.2 0.1 -0.6 0.1 -0.1
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.3 0.4 0.6 1.5 -0.3 -1.3 -0.5 1.3 0.9 0.9
Ulcerative Colitis 1.7 2.4 5.7 -2.0 -2.4 0.3 -0.7 1.2 1.0 -1.9 -1.2 -2.0
Blood Eosinophil Count 0.3 1.9 7.5 0.6 2.5 -2.7 -1.6 -0.4 -0.0 -0.6 -0.3 -0.3
Blood Platelet Count 0.1 0.7 3.8 -0.2 1.2 -1.9 -0.4 0.9 -0.1 0.1 0.6 0.1
Blood Red Count 0.3 2.7 13.1 -3.6 0.4 -0.7 -0.1 0.3 0.2 -1.1 -2.1 -2.2
Blood White Count 0.2 1.8 5.8 -2.4 2.0 -0.4 -0.6 -1.1 -1.5 0.9 -1.2 0.4
Heel T-Score 0.1 1.0 2.4 -1.4 -1.5 0.5 -1.4 0.4 0.2 -0.9 -0.2 -1.1
BMI 0.4 2.2 9.5 -1.0 -0.7 -0.0 -3.1 -1.6 -1.9 0.7 -1.2 0.4
Height 0.1 2.3 7.2 -0.3 0.3 0.6 2.7 1.7 1.6 -1.6 -1.0 -1.8
Waist Hip Ratio (WHR) 0.3 1.5 5.6 0.5 0.3 -1.9 2.4 0.6 1.0 0.0 1.7 0.5
Systolic Blood Pressure 0.4 1.8 7.0 -2.6 1.2 0.4 -1.7 -1.3 -1.2 -0.5 -1.1 -0.7
Smoking Status 0.5 1.1 5.8 0.5 0.9 -0.5 2.4 -0.0 0.7 0.6 0.9 1.0
Allergy or Eczema 0.8 2.0 8.1 2.9 0.0 -0.3 -0.9 0.9 1.3 -0.2 2.5 0.2
Cardiovascular Disease 0.2 0.6 2.1 -1.4 0.6 0.4 -0.6 -0.3 -0.2 -0.8 -1.1 -0.5
Hypothyroidism (self reported) 0.2 0.5 1.4 1.2 1.1 -0.9 0.3 0.7 0.3 -0.8 0.7 -0.0
Respiratory disease 0.4 0.9 2.7 0.9 1.1 0.1 -0.2 -1.2 -0.9 0.9 1.0 1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.2 0.1 -0.9 0.5 0.3 -1.5 -0.6 1.9 -0.6 2.0
Lung FEV1/FVC ratio 1.9 9.4 31.7 3.0 3.6 -3.5 0.5 2.7 2.8 -1.3 5.6 -1.2
Lung FVC 0.2 1.0 3.7 -0.1 -0.4 1.9 -1.8 -0.2 -0.1 0.5 -1.3 0.2
Neuroticism 0.1 0.2 0.8 -0.9 -0.7 -0.1 -0.3 -0.4 0.1 -0.4 -0.1 -0.3
Chronotype (morning person) 0.7 1.5 3.8 1.3 -0.5 -0.5 -1.1 1.7 0.9 -2.0 -1.1 -1.1
Hair Pigment 0.1 1.8 4.4 0.4 1.6 -1.2 -1.4 2.1 1.2 -1.7 -0.0 -1.0
Tanning 0.0 0.5 2.0 -0.6 0.1 1.4 -0.8 0.7 0.3 -0.4 -0.8 -0.7
Hand grip strength (left) 0.8 2.2 4.9 -0.1 2.2 -1.0 -0.7 1.8 2.0 -2.0 0.0 -1.4
Number of treatments/medications taken 0.6 1.0 3.0 -0.8 0.8 -0.5 0.2 1.7 1.0 -1.1 -0.4 -1.5
Average weekly spirits intake 0.6 0.8 1.8 0.2 -0.0 -1.1 1.2 0.3 0.7 -1.3 1.0 -1.0
Sensitivity / hurt feelings 0.7 1.2 2.5 -1.1 -0.7 0.5 -1.6 0.2 0.2 -1.2 -1.6 -1.5
Frequency of depressed mood in last 2 weeks 0.2 0.3 2.7 -0.2 1.6 0.2 -0.1 -0.2 -0.3 0.2 0.1 0.3
Hearing difficulty/problems: Yes 0.8 1.2 2.8 0.8 1.0 -0.9 0.8 -1.7 -0.9 1.0 1.4 1.1
Relative age of first facial hair 1.7 3.5 7.6 -0.8 -1.2 -0.8 1.9 2.8 2.5 -2.5 0.2 -2.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.3 -1.8 -1.5 0.1 0.1 0.5 0.2 -0.7 -1.1 -1.3
Ever used hormone-replacement therapy (HRT) 2.3 2.9 7.1 -1.3 -1.0 0.2 -2.4 0.7 -0.2 -1.9 -2.6 -2.7
Ever had hysterectomy (womb removed) 0.3 0.4 1.1 0.1 -0.3 -1.0 -0.8 0.7 -0.1 -0.8 -0.1 -0.7
Systolic blood pressure, automated reading 0.5 1.4 4.8 -2.2 0.6 -0.7 -1.3 -0.5 -0.6 -1.3 -0.6 -1.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.6 -1.1 -1.0 -0.8 1.9 0.1 0.3 0.7 0.3 0.6
Angina 0.3 0.4 2.1 -0.8 1.5 0.3 0.1 -0.0 -0.5 -0.2 -0.8 -0.1
Medication for hormone replacement therapy 1.7 1.9 5.5 -1.3 -1.8 0.5 0.1 0.4 0.1 -1.4 -2.3 -2.1
Vitamin and mineral supplements 0.8 1.0 2.4 -0.5 0.4 -0.1 -1.3 0.7 0.4 -1.5 -1.4 -1.6
Supplements: Zinc 2.8 3.0 8.5 1.8 2.9 -2.3 1.5 1.1 1.1 -0.3 2.2 0.2
Medication: Co-codamol 0.7 0.8 3.0 0.5 1.2 -0.8 1.7 0.3 0.3 -0.2 0.9 0.6
Medication: Metformin 0.2 0.3 1.3 -0.6 0.5 -0.3 0.0 0.4 0.2 0.6 -1.1 0.6
Diabetes (father) 3.4 4.2 8.7 -2.6 -0.8 2.9 -0.8 -2.1 -2.6 2.3 -2.0 0.9
Diabetes (mother) 1.0 1.3 3.5 -0.6 0.5 1.9 -0.4 -1.3 -1.2 1.7 -0.4 1.2
Severe depression (siblings) 1.4 1.6 3.8 1.9 1.2 0.2 1.1 -0.5 -0.5 1.5 1.1 2.0
Pack years adult smoking proportion 0.7 1.0 2.7 0.4 -0.6 0.4 0.9 -1.2 -0.9 1.6 0.4 1.7
Impedance of leg (right) 0.2 1.1 3.6 -1.6 0.1 1.8 0.4 -0.1 0.2 1.9 -0.3 0.5
Leg fat-free mass (left) 0.1 0.4 1.7 -0.1 -0.5 -0.7 -0.9 0.2 -0.3 -1.3 -0.3 -0.4
Trunk fat percentage 0.6 2.4 6.9 -2.6 -1.4 0.8 -2.4 0.0 -1.0 0.3 -2.2 -0.3
Hand grip strength (right) 0.8 2.1 4.9 0.5 2.2 -0.6 -0.3 1.8 2.0 -1.8 1.0 -1.3
Townsend deprivation index at recruitment 0.9 1.2 3.0 1.3 -0.3 -1.0 1.7 0.6 1.3 -0.5 1.7 0.4
Current tobacco smoking 0.4 0.6 1.1 1.0 -0.8 -0.3 0.7 -0.9 0.0 0.6 0.9 1.0
Average weekly fortified wine intake 0.7 0.8 2.7 -1.0 -1.6 -0.3 -0.8 -0.6 -0.7 -1.0 -0.7 -0.7
Maternal smoking around birth 0.5 0.7 2.5 0.8 -1.0 -1.0 0.5 0.5 0.2 -0.6 1.6 -0.1
Fed-up feelings 0.8 1.5 4.2 -1.9 0.3 -0.5 -0.8 0.3 0.3 -1.3 -2.0 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.9 0.3 1.0 -0.8 -0.9 -0.1 -0.2 0.0 0.7 0.6
Relative age voice broke 1.8 2.8 7.2 0.8 -1.5 -0.7 2.0 2.1 2.7 -2.0 0.5 -1.4
Taking other prescription medications 0.3 0.4 0.8 -0.7 -0.8 -0.9 0.1 0.6 0.1 -0.5 -0.6 -0.7
Age when periods started (menarche) 0.8 2.0 5.4 1.2 -2.3 -1.1 0.9 1.4 2.2 -0.7 0.9 -0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 4.2 0.3 1.4 -2.1 0.3 0.6 0.3 -0.7 0.5 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 5.8 0.9 -0.5 -2.4 -0.6 1.2 1.3 -0.9 2.0 -0.7
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.6 0.7 1.1 -1.3 -1.1 -0.5 -0.1 -0.5 0.1 -0.8
Qualifications: CSEs or equivalent 0.8 1.1 2.4 -1.6 1.0 -1.0 0.5 1.4 1.1 -0.9 -0.3 -1.0
Serious illness, injury or assault to yourself 0.4 0.4 1.2 -0.1 0.9 0.2 0.4 -0.8 -1.1 0.5 -0.7 0.4
High blood pressure 0.4 1.1 3.0 -1.6 -0.1 0.2 -1.0 0.8 0.5 -1.2 -1.7 -1.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.1 1.3 -0.0 -0.0 -1.0 -0.2 0.1 0.2 1.5 0.3
Multivitamins +/- minerals 1.3 1.6 4.2 0.8 0.1 0.8 1.6 -0.8 -0.9 2.0 0.9 2.1
Stomach or abdominal pain in last month 1.9 2.3 8.3 0.9 0.4 -0.5 2.3 -0.6 -0.2 1.4 2.9 2.0
Supplements: Glucosamine 0.9 1.2 4.0 1.0 0.0 -0.7 0.6 1.5 1.1 -2.0 0.0 -1.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 7.1 -0.6 -2.7 1.4 1.0 -0.9 0.1 0.2 -0.8 -0.1
Medication: Atenolol 0.4 0.5 1.6 -0.5 0.8 0.2 1.3 0.8 0.4 0.1 -0.8 0.1
Medication: Levothyroxine sodium 0.5 0.8 2.7 1.6 0.4 -1.0 1.1 0.2 0.3 -0.2 1.3 0.5
Sitting height 0.0 0.1 0.3 -0.2 0.6 0.5 -0.0 -0.2 -0.3 -0.2 -0.3 0.2
Chronic bronchitis/emphysema (father) 2.3 2.7 5.3 1.5 0.9 -2.3 0.2 1.6 1.8 -1.8 2.2 -1.3
High blood pressure (mother) 0.7 1.0 4.7 -0.6 0.4 -0.1 -2.2 -1.1 -1.5 0.5 0.3 0.1
Body mass index (BMI) 0.4 1.5 6.5 -1.0 -0.7 -0.7 -2.5 -0.8 -1.9 0.5 -0.4 0.6
Impedance of leg (left) 0.2 0.8 2.6 -1.4 -0.1 1.6 0.2 0.3 0.5 1.4 -0.9 0.1
Leg predicted mass (left) 0.1 0.4 1.7 -0.2 -0.5 -0.6 -1.0 0.1 -0.4 -1.3 -0.3 -0.5
Trunk fat mass 0.4 1.8 4.9 -2.2 -1.3 0.6 -2.2 -0.0 -1.0 0.1 -1.8 -0.3
Waist circumference 0.1 0.5 1.3 -0.6 -0.4 -0.3 -0.8 -0.7 -1.1 0.7 0.0 1.0
Number of incorrect matches in round 0.5 0.8 2.4 -0.8 -0.1 1.2 -1.6 -0.8 -0.4 -0.3 -1.3 -0.5
Past tobacco smoking 0.9 1.6 4.0 -1.2 -1.7 0.9 -2.0 -0.3 -1.0 -0.4 -1.8 -0.9
Alcohol usually taken with meals 1.6 2.5 5.2 -1.0 -2.1 -1.6 1.2 1.6 1.1 -2.1 0.5 -2.3
Nervous feelings 0.5 0.8 3.8 0.4 -0.7 -0.7 1.9 0.4 0.8 0.1 1.4 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 3.6 0.1 1.9 -0.3 -1.4 -0.1 0.3 -0.1 0.1 0.1
Hearing difficulty/problems with background noise 0.6 0.9 4.6 -0.2 2.1 -0.1 -1.2 -0.8 -0.6 -0.6 -0.4 -0.8
Hair/balding pattern: Pattern 2 0.5 0.6 2.3 1.5 -0.5 -0.8 -0.0 0.0 -0.1 -1.0 1.0 -0.3
Had menopause 1.1 1.3 4.1 0.0 -0.5 1.9 -1.5 -1.0 -0.8 -0.3 -2.0 -0.4
Had other major operations 0.4 0.5 2.5 -0.4 1.6 0.0 -0.9 -0.1 -0.7 0.4 -0.9 0.1
Forced vital capacity (FVC) 0.1 0.4 1.2 0.7 0.2 1.1 -0.7 0.2 0.7 -0.2 -0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.3 1.1 -0.4 -1.5 -0.7 1.2 1.2 -0.8 1.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.2 0.4 0.6 0.2 1.5 -0.2 0.2 0.6 0.7 0.7
Qualifications: None of the above 0.9 2.0 7.0 2.1 0.9 -2.6 0.1 0.2 0.8 -0.0 2.1 0.6
Financial difficulties in last 2 years 1.1 1.5 5.6 0.2 1.2 -2.4 0.5 0.7 0.5 -1.1 1.9 -0.6
Mouth/teeth dental problems 0.2 0.3 1.5 0.1 0.6 -0.0 -1.2 0.1 0.3 -0.6 0.2 -0.0
Heart attack 0.5 0.6 2.4 -0.4 -0.1 -0.4 0.7 0.9 1.6 -1.0 0.3 -0.6
Allergy 0.4 0.8 1.5 -1.0 0.5 0.1 1.2 1.0 1.0 -0.9 -1.1 -1.0
Pain all over the body in last month 0.9 0.9 3.6 -0.6 -1.9 0.7 -0.6 0.6 0.4 -0.2 -1.6 -0.6
Diabetes (self-reported) 0.4 0.6 1.6 0.3 0.5 0.3 0.2 -0.8 -0.3 1.3 -0.9 1.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.1 0.4 0.5 -1.1 0.3 0.9 0.5 -1.4 0.1 -1.2
Medication: Ramipril 0.4 0.5 1.6 0.4 0.8 -0.2 -0.6 -0.5 -0.5 1.1 0.3 1.3
Medication: Simvastatin 0.8 1.2 4.0 -1.2 2.0 -0.3 -1.5 -0.2 -0.7 -0.9 -0.8 -1.1
Fluid intelligence score 1.1 2.3 6.4 -1.6 -0.8 2.5 -1.8 -0.6 -1.1 0.0 -2.4 -0.3
Illnesses of siblings 0.8 1.1 3.0 0.9 1.3 0.6 -0.4 -0.9 -1.0 1.7 0.3 1.3
Neuroticism score 0.2 0.3 0.9 -0.8 0.2 -0.4 -0.5 0.0 0.1 -1.0 -0.4 -0.9
Weight 0.1 0.6 2.9 -0.7 -0.8 -0.2 -1.7 -0.1 -0.9 -0.3 -0.5 0.1
Impedance of arm (right) 0.3 1.2 2.4 -1.5 -0.8 1.2 1.0 0.8 1.3 -0.2 -1.2 -1.3
Arm fat percentage (right) 0.4 1.7 6.3 -2.2 -0.8 0.0 -2.5 -0.4 -1.4 0.5 -1.0 -0.2
Trunk fat-free mass 0.1 0.7 1.9 0.9 0.4 -1.4 -0.3 0.6 0.1 -1.2 1.0 -0.2
Hip circumference 0.4 1.7 6.2 -1.6 -0.9 0.9 -2.5 -0.5 -1.3 -0.0 -1.7 -0.0
Time employed in main current job 1.2 1.4 3.8 0.3 0.5 -0.5 -1.8 1.3 1.0 -1.6 -0.2 -2.0
Alcohol intake versus 10 years previously 0.5 0.7 3.6 0.9 -0.1 -1.9 -1.0 0.6 0.4 -0.6 -0.2 -0.5
Father’s age at death 0.6 0.8 2.5 0.4 -1.5 1.6 -0.1 0.8 0.5 -0.4 -1.0 -0.5
Worrier / anxious feelings 0.2 0.4 1.0 -0.9 0.5 1.0 -1.0 0.2 0.5 -0.4 -0.4 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.4 0.4 0.0 -1.2 -0.3 1.0 0.8 -1.0 1.0 -0.8
Falls in the last year 0.3 0.4 1.0 0.6 -0.3 -0.1 1.0 1.0 0.3 -0.6 0.6 -0.1
Hair/balding pattern: Pattern 3 0.3 0.4 1.7 -1.2 0.4 -0.4 -0.2 0.0 -0.2 0.5 -1.3 -0.5
Number of live births 1.2 1.7 4.4 0.6 0.5 -2.1 0.7 1.7 2.0 -1.3 0.9 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.6 0.9 1.3 0.1 -0.8 0.2 0.4 -0.1 0.3 -0.2
Pulse rate 0.1 0.2 0.8 0.3 -0.9 -0.2 -0.6 -0.1 0.3 -0.6 0.2 -0.2
Happiness 0.7 0.9 2.6 0.1 -1.1 -1.1 0.1 0.3 1.0 -1.6 0.1 -1.4
Noisy workplace 1.5 1.8 3.7 1.0 0.7 -1.1 1.7 -0.9 -0.9 1.9 1.8 1.7
Qualifications: A levels/AS levels or equivalent 0.8 1.7 5.6 -1.0 0.4 2.4 -1.5 -1.1 -1.4 0.1 -1.8 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.2 -1.1 -0.5 0.4 1.0 -0.7 -0.2 0.6 0.0 0.4
Mouth/teeth dental problems: Dentures 0.7 1.2 2.1 -1.3 0.0 1.3 0.5 -1.4 -1.1 1.4 -1.2 0.8
Asthma 0.4 0.8 1.9 1.0 0.7 -0.7 -0.4 -1.0 -1.0 0.6 0.9 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.0 0.4 0.6 -0.2 1.0 -1.0 -1.4 1.0 0.7 1.3
Medication: Cholesterol lowering 0.5 0.7 3.8 -1.9 0.9 0.7 0.2 -0.2 -0.7 -0.2 -0.8 -0.5
Depression (self-reported) 0.7 0.8 2.1 -1.4 -0.8 1.1 -1.0 0.0 -0.1 -0.1 -1.5 -0.7
Medication: Lansoprazole 1.4 1.6 7.7 2.8 -1.3 -0.3 0.7 0.5 1.3 0.4 1.3 0.9
Prospective memory result 0.5 0.7 3.8 -0.6 0.4 -0.3 -2.0 -0.6 -0.7 -0.5 0.7 -0.5
Lung cancer (father) 0.5 0.6 1.9 -0.7 -0.1 1.0 0.6 0.8 0.0 -0.7 -1.4 -1.0
Illnesses of mother 0.7 0.9 4.1 1.2 -0.2 -0.1 2.0 0.5 0.9 0.4 1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 6.0 1.5 2.5 -1.0 0.1 0.9 1.3 -1.0 1.3 -0.6
Pulse wave Arterial Stiffness index 0.8 1.0 3.0 0.3 0.1 1.7 0.0 -1.6 -1.0 0.8 -0.6 1.0
Impedance of arm (left) 0.3 1.2 3.0 -1.3 -0.8 1.3 1.7 0.9 1.2 -0.2 -0.9 -0.9
Arm fat mass (right) 0.3 1.2 6.1 -1.4 -0.7 -0.2 -2.5 -0.4 -1.4 0.2 -0.7 0.0
Trunk predicted mass 0.1 0.6 1.8 0.9 0.5 -1.3 -0.3 0.6 0.1 -1.1 1.1 -0.1
Standing height 0.2 1.7 3.8 -0.1 -0.1 0.8 1.4 1.8 1.7 -1.9 -0.5 -1.7
Length of working week for main job 0.5 0.5 1.7 0.4 0.1 -1.3 -0.3 0.9 0.8 -0.3 1.0 -0.4
Exposure to tobacco smoke at home 1.4 1.6 4.5 -1.9 -1.0 0.3 -1.1 0.7 0.5 -1.1 -2.1 -1.3
Breastfed as a baby 1.2 1.5 3.5 -1.9 -0.3 1.0 -0.5 0.8 0.8 -1.3 -1.5 -1.8
Tense / ‘highly strung’ 0.4 0.6 2.4 0.7 -0.4 -0.8 0.8 0.3 0.4 -0.9 1.5 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 3.0 -0.0 1.7 -0.7 -0.2 0.3 -0.2 -0.1 -0.2 0.3
Hair/balding pattern: Pattern 4 0.2 0.4 1.4 0.9 0.8 1.2 -0.8 -0.3 0.6 -0.0 -0.0 0.6
Birth weight of first child 0.1 0.2 1.4 0.5 1.2 -0.3 -0.0 0.2 -0.1 -0.1 -0.1 0.1
Peak expiratory flow (PEF) 0.2 0.4 1.1 1.0 0.9 -0.7 -0.0 -0.3 -0.4 -0.1 1.1 0.5
Pulse wave reflection index 0.6 0.7 2.2 0.7 1.5 -1.2 1.2 0.6 0.4 -0.1 0.5 0.5
Ever highly irritable/argumentative for 2 days 0.9 1.1 4.1 1.5 1.0 -1.2 0.4 0.1 0.4 0.5 2.0 0.8
Loud music exposure frequency 0.2 0.2 1.1 1.0 -0.5 -0.3 0.3 0.0 0.1 -0.3 0.1 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 -0.4 0.2 1.0 0.5 0.0 -0.3 -0.3 -0.7 -0.6
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 5.2 2.3 0.0 -0.8 1.6 0.1 0.4 0.5 1.3 0.7
Blood clot in the leg (DVT) 0.4 0.5 1.2 0.2 0.2 -1.1 0.6 1.0 0.1 -0.7 -0.6 -1.1
Medication: Paracetamol 0.2 0.4 1.4 -0.9 -0.0 -1.2 0.3 0.7 0.0 -0.0 0.7 -0.5
Headache pain in last month 1.4 2.4 6.6 2.0 1.3 -1.0 2.5 0.5 0.8 0.3 2.6 1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.4 1.5 -0.3 -1.5 -0.2 -0.0 0.2 -0.0 1.2 0.4
Glaucoma (self-reported) 0.7 0.8 1.5 -1.0 -0.1 1.2 1.1 -1.0 -0.7 1.1 -0.4 0.7
Gout (self-reported) 0.6 0.8 1.5 -1.2 0.6 0.7 -1.0 0.6 0.2 -0.6 -1.2 -1.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.2 2.1 0.6 -1.8 -0.3 0.7 0.8 -0.9 1.1 -0.1
Medication: Amlodipine 0.7 1.0 3.3 -0.1 -0.6 1.8 -0.7 0.8 0.7 -1.2 -0.7 -1.2
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.6 1.0 0.8 0.9 -0.5 -1.3 -1.6 1.5 0.1 1.6
Birth weight 0.5 1.1 4.2 -0.4 2.0 -1.0 1.9 -0.2 -0.3 -0.1 0.7 0.3
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 -0.7 0.2 -0.5 0.1 0.2 -0.5 0.6 0.8 -0.0
High blood pressure (siblings) 0.3 0.4 1.0 -0.1 -1.0 -0.7 0.8 0.6 0.6 -0.8 0.4 -0.4
Forced vital capacity (FVC), Best measure 0.2 0.6 1.9 1.1 1.4 0.1 -0.2 0.5 1.1 -0.6 0.3 -0.3
Body fat percentage 0.6 2.4 8.1 -2.8 -1.2 0.5 -2.5 -0.1 -1.2 0.5 -1.9 -0.3
Leg fat percentage (right) 0.6 2.2 6.9 -2.6 -0.9 0.4 -2.6 -0.6 -1.5 1.1 -1.2 0.3
Arm fat-free mass (right) 0.1 0.4 1.0 0.7 -0.0 -0.8 -0.9 0.1 -0.3 -1.0 0.4 0.1
Exposure to tobacco smoke outside home 0.8 1.0 2.1 0.7 -0.0 -1.4 0.2 1.5 1.4 -1.0 1.0 -0.8
Comparative body size at age 10 0.1 0.4 0.8 0.7 0.2 -0.1 0.4 -0.6 -0.9 0.8 0.5 0.8
Number of full brothers 0.6 0.8 1.5 -1.2 -0.4 0.9 0.2 -0.6 -0.7 1.2 -1.2 1.0
Worry too long after embarrassment 0.1 0.1 0.4 0.5 -0.2 -0.3 0.5 -0.6 -0.2 -0.2 -0.3 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.9 0.4 1.0 0.8 -1.0 -1.1 -0.9 1.6 -0.2 1.7
Wheeze or whistling in the chest in last year 0.8 1.3 3.2 -0.4 0.4 1.2 -1.8 -1.5 -1.2 1.3 0.4 1.3
Number of children fathered 1.7 2.0 4.6 -0.7 -1.1 -1.0 1.1 1.3 1.7 -2.1 -0.2 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.6 1.3 0.7 -0.4 0.5 0.6 0.9 -0.7 0.2 -0.8
Age at first live birth 0.4 0.6 1.4 -1.0 -1.2 0.4 0.4 1.0 0.4 -0.9 -0.2 -1.1
Pulse wave peak to peak time 0.6 0.7 2.2 -0.4 -0.0 -1.2 0.0 1.5 0.8 -0.7 0.4 -1.0
Health satisfaction 0.9 1.2 3.7 0.2 -1.5 0.4 -0.9 -1.9 -1.4 0.9 -0.3 0.9
Shortness of breath walking on level ground 1.8 2.1 5.3 0.0 -1.2 0.5 0.5 -2.0 -1.5 2.3 0.7 2.3
Qualifications: College or University degree 0.4 1.1 3.2 -0.6 -1.1 1.8 -0.8 -1.1 -1.1 0.8 -1.2 0.5
Eye problems/disorders: None of the above 0.7 0.8 2.9 1.7 0.2 -1.1 -0.3 -0.4 -0.2 -0.1 1.5 0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.4 -0.3 -1.2 -0.0 0.9 0.4 0.5 -0.1 1.0 -0.3
Emphysema/chronic bronchitis 0.2 0.2 0.7 -0.6 0.8 0.6 -0.8 0.3 -0.2 0.2 0.2 0.2
Medication for pain relief, constipation, heartburn 0.4 0.6 3.6 1.9 -0.3 0.2 0.1 0.0 1.3 -0.4 -0.3 0.0
Neck or shoulder pain in last month 0.1 0.1 0.3 -0.4 0.6 0.1 0.3 -0.4 0.0 0.0 0.1 0.3
Medication: Blood pressure 0.4 0.8 3.0 -1.7 -0.6 1.5 -0.2 0.2 -0.2 -0.0 -1.1 -0.3
Angina (self-reported) 0.4 0.5 2.7 -0.7 1.6 0.5 0.4 0.1 -0.5 -0.2 -0.9 -0.1
Migraine (self-reported) 0.6 0.7 1.5 0.1 0.9 1.2 -0.2 1.2 1.0 -0.1 1.0 -0.4
Medication: Ibuprofen 0.7 0.8 3.1 -0.5 0.8 -0.5 0.8 -0.9 -1.7 0.7 0.3 0.9
Medication: Allopurinol 0.9 1.2 5.3 -2.3 -0.0 0.8 -1.2 0.7 0.3 -0.4 -1.3 -0.9
Medication: Omeprazole 3.7 4.4 10.8 -2.7 -0.4 -0.1 -1.8 2.3 1.6 -2.7 -1.7 -3.3
Medication: Seretide 50 evohaler 0.3 0.3 1.0 -0.4 0.4 -0.5 -0.3 1.0 0.3 -0.7 0.2 -0.5
Mean time to correctly identify matches 1.3 2.5 6.8 -0.3 -1.0 -0.7 -0.4 2.6 1.7 -2.2 -0.2 -2.4
Heart disease (mother) 0.5 0.6 1.6 0.4 -0.0 -1.1 0.1 0.7 0.6 -1.3 -1.3 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.0 1.7 -1.4 -0.2 -0.7 -1.7 -0.8 0.6 -0.3 1.6
Whole body fat mass 0.5 2.1 6.6 -2.3 -1.2 0.4 -2.6 -0.4 -1.4 0.3 -1.8 -0.1
Leg fat mass (right) 0.5 1.9 7.6 -1.9 -0.9 0.4 -2.8 -0.8 -1.6 0.7 -1.2 0.3
Arm predicted mass (right) 0.1 0.4 1.0 0.7 -0.0 -0.8 -1.0 0.0 -0.5 -0.8 0.6 0.2
Pulse rate, automated reading 0.4 1.3 3.7 0.8 0.1 -0.5 -0.1 -1.1 -0.7 1.7 1.6 1.9
Alcohol intake frequency. 0.3 0.6 1.5 1.1 1.2 0.2 -0.3 -0.5 -0.3 1.0 -0.6 0.9
Comparative height size at age 10 0.1 0.6 2.4 -0.6 1.0 1.6 0.6 -0.2 -0.3 -0.3 -0.9 -0.3
Number of full sisters 0.2 0.3 0.9 0.1 0.6 0.1 -0.9 0.3 0.4 -0.3 0.9 -0.1
Suffer from ‘nerves’ 0.6 0.9 2.3 1.5 0.5 -0.5 1.5 0.1 -0.1 0.3 1.4 1.2
Overall health rating 0.4 0.8 3.7 -0.4 -0.5 -0.6 -1.9 -1.0 -1.1 0.5 0.5 0.4
Chest pain or discomfort 0.2 0.3 0.8 0.4 0.7 -0.6 -0.2 0.9 0.4 -0.5 -0.2 -0.2
Had major operations 1.2 1.4 3.2 -1.8 0.2 1.8 -0.5 -0.4 -1.5 0.6 -1.7 -0.2
Age at last live birth 0.7 1.0 2.5 0.4 -0.7 -1.0 1.6 1.1 1.0 -0.8 1.3 -0.1
Family relationship satisfaction 0.6 0.8 1.4 -0.9 -1.1 -0.0 -0.7 1.0 0.1 -1.2 -0.9 -1.2
Leg pain on walking 0.4 0.5 1.5 -0.6 -1.2 0.0 -0.9 0.0 0.7 -0.8 -0.3 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.3 -1.1 1.1 -0.2 -0.9 -0.4 -0.5 0.4 0.4 -0.0
Commuting to job workplace: Car/motor vehicle 2.6 2.9 5.5 -2.3 1.5 1.9 -2.4 -1.3 -2.0 0.7 -1.7 -0.6
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 4.9 0.4 -1.5 1.2 -2.2 -1.4 -1.5 1.1 -1.3 0.9
Medication: Aspirin 0.3 0.4 1.6 -1.3 0.7 0.5 -0.4 0.2 -0.3 -0.1 -0.8 -0.1
Supplements: Vitamin C 1.4 1.7 4.5 -1.0 -0.2 0.5 -0.4 -2.1 -2.0 1.7 0.7 1.3
Knee pain experienced in last month 0.3 0.5 2.6 0.7 1.6 0.1 -0.0 0.3 0.0 -0.7 -0.1 -0.6
Hypertension (Self-reported) 0.4 1.0 2.7 -1.6 0.0 0.3 -1.1 0.6 0.5 -1.1 -1.6 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.6 0.0 -1.9 0.9 0.0 0.3 -0.1 0.2 -0.9 -0.4
Illnesses of father: Heart disease 2.0 2.7 6.3 -0.6 -1.1 -1.6 -0.2 1.9 2.3 -2.5 -0.4 -2.3
Illnesses of siblings: Diabetes 0.3 0.4 1.0 -1.0 -0.3 0.8 0.2 -0.2 1.0 -0.4 0.3 -0.4
Smoking status: Previous 0.8 1.1 4.1 -0.1 2.0 -0.7 1.4 0.6 1.2 0.2 1.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.7 0.8 0.7 -0.5 -0.7 -0.4 -0.4 0.2 0.8 0.6
Whole body fat-free mass 0.1 0.5 1.6 0.6 -0.0 -1.2 -0.5 0.4 -0.1 -1.3 0.6 -0.2
Leg fat-free mass (right) 0.1 0.6 2.8 0.1 -0.5 -0.8 -0.7 0.4 -0.2 -1.7 -0.4 -0.7
Arm fat percentage (left) 0.4 1.8 5.6 -2.2 -1.1 0.3 -2.4 -0.5 -1.6 0.6 -1.1 0.0
Average weekly red wine intake 0.6 0.9 2.6 -0.1 -0.7 1.6 0.2 0.7 0.6 -1.2 -0.9 -1.4
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.8 2.2 -0.1 -1.8 -1.5 0.2 -0.1 -0.9 0.1 -0.4
Mood swings 0.4 0.7 1.3 0.3 0.6 -1.1 -0.3 0.7 0.9 -1.2 -0.8 -1.0
Loneliness, isolation 0.4 0.5 1.4 -1.0 -0.3 -1.2 -0.8 0.1 -0.3 -0.8 -0.6 -0.8
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.1 -0.3 0.4 -0.3 0.1 0.1 -0.3 -0.6 -0.5
Ever had bowel cancer screening 0.3 0.3 1.0 0.7 0.4 -1.0 0.7 0.2 0.1 -0.1 0.6 0.2
Diabetes diagnosed by doctor 0.5 0.9 3.2 0.8 -0.2 -0.1 0.3 -1.0 -0.6 1.6 -0.2 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 -0.2 0.8 -1.0 0.7 -0.0 0.5 -0.2 -0.5 -0.4
Friendships satisfaction 0.9 1.1 3.2 0.0 -0.5 0.5 -1.8 -1.5 -1.6 0.5 -0.3 0.7
Qualifications: nursing, teaching 0.6 1.0 2.6 -0.4 0.3 1.3 -0.4 0.6 0.8 -1.0 -1.6 -1.4
Commuting to job workplace: Walk 2.2 2.4 4.7 2.2 -0.1 -1.5 2.1 1.6 2.0 -0.2 1.9 0.4
Eye problems/disorders: Cataract 1.1 1.3 3.3 -1.8 1.1 1.8 -0.6 -0.4 -0.7 0.8 -1.4 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 0.8 0.6 -1.0 -0.3 0.2 0.3 -0.7 0.1 -0.2
Medication for cholesterol 1.1 1.6 3.7 1.2 0.0 0.8 0.7 -1.2 -0.9 1.8 1.6 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.8 0.0 0.4 -0.3 0.9 -0.0 -0.7 -0.1 0.9 0.3
Back pain experienced in last month 1.0 1.4 6.2 -1.0 2.5 -1.7 0.5 -0.3 -0.3 0.3 1.1 0.8
Mineral and other dietary supplements 0.1 0.1 0.4 -0.1 0.6 -0.1 0.3 -0.3 -0.0 0.6 0.4 0.3
Breast cancer (self-reported) 0.8 1.0 3.1 0.2 -1.0 -0.5 1.8 0.9 0.6 -1.1 -0.8 -1.2
Asthma (self-reported) 0.3 0.7 1.3 0.7 0.9 -0.7 -0.4 -1.1 -1.1 0.6 0.6 1.1
Osteoporosis (self-reported) 0.7 0.9 4.0 0.3 2.0 -0.2 0.4 -0.7 -0.5 1.2 0.3 1.4
Osteoarthritis (self-reported) 1.2 1.5 4.4 0.1 -0.8 -0.3 1.1 1.5 1.2 -2.1 -0.6 -1.8
Medication: Aspirin 0.3 0.3 1.3 -0.8 1.2 0.8 0.2 -0.0 -0.2 0.5 -0.2 0.5
Medication: Gliclazide 1.5 1.7 4.8 1.5 -0.1 -0.0 1.9 -0.1 0.0 1.9 1.1 2.2
Illnesses of father: None of the above (group 1) 0.6 0.7 2.4 0.5 0.4 0.5 1.5 -0.5 -0.3 1.1 0.1 1.4
Smoking status: Current 0.4 0.7 1.6 1.0 -1.2 -0.2 1.0 -0.8 0.1 0.6 0.6 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.2 0.6 0.6 -1.5 -0.1 0.9 0.8 -0.6 0.7 -0.9
Whole body water mass 0.1 0.4 1.6 0.6 -0.0 -1.0 -0.7 0.3 -0.2 -1.2 0.6 -0.2
Leg predicted mass (right) 0.1 0.5 2.5 0.2 -0.5 -0.8 -0.7 0.4 -0.2 -1.6 -0.5 -0.6
Arm fat mass (left) 0.4 1.5 6.3 -1.5 -0.9 -0.1 -2.5 -0.5 -1.6 0.3 -0.8 0.1
Number of self-reported non-cancer illnesses 0.8 1.4 2.5 -1.2 1.2 -0.9 -1.1 1.3 0.9 -1.5 -0.6 -1.6
Average weekly champagne plus white wine intake 0.6 0.9 3.8 -0.8 -1.9 1.6 0.1 -0.1 -0.4 0.6 -0.5 0.4
Miserableness 0.2 0.3 1.4 0.2 1.1 0.5 -1.2 0.0 0.1 -0.1 0.4 -0.1
Guilty feelings 1.1 1.6 5.7 0.1 1.3 -2.4 0.9 1.0 1.3 -1.5 0.4 -1.2
Wears glasses or contact lenses 0.6 0.7 3.1 0.1 1.8 -0.2 1.1 0.8 0.7 -0.3 -0.3 -0.6
Ever taken oral contraceptive pill 1.0 1.2 5.0 0.5 1.0 -1.4 -0.1 0.9 1.0 -0.6 2.2 -0.4
Hearing aid user 0.6 0.6 1.6 -0.8 -1.0 1.3 0.5 -0.4 -0.2 0.9 -0.9 0.5
Mother’s age at death 2.9 3.7 6.9 0.2 -1.6 -0.7 2.0 2.6 2.6 -2.3 1.2 -2.3
Financial situation satisfaction 1.0 1.2 3.8 1.2 0.9 -2.0 0.2 1.0 0.9 -0.1 1.7 0.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.9 -0.6 1.3 -1.3 -0.4 0.6 0.4 -1.2 -0.5 -1.4
Commuting to job workplace: Public transport 1.8 2.2 6.5 2.4 0.6 0.4 2.5 1.2 1.4 -0.4 1.8 0.4
Eye problems/disorders: Glaucoma 0.5 0.6 1.6 -1.3 -0.5 1.1 0.8 -0.7 -0.7 0.3 -0.9 -0.2
Medication: Blood pressure 0.3 0.6 2.5 -0.3 1.4 -0.5 -1.6 0.1 0.2 -0.5 -0.3 -0.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 0.1 -0.2 -0.8 1.0 1.1 0.7 0.3 1.1 0.4
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.2 0.1 -0.2 -0.3 -0.1 0.2 -0.0 -0.3 0.4 -0.1
High cholesterol (Self-reported) 0.3 0.5 1.5 -0.4 0.7 0.3 0.1 0.5 0.3 -1.2 -0.8 -1.0
Medication: Bendroflumethiazide 0.4 0.6 1.8 -1.2 0.5 0.1 -1.3 0.7 0.5 -0.4 -0.6 -0.6
Medication: Paracetamol 0.5 0.8 3.0 -0.7 0.5 -1.7 -0.2 0.9 0.1 -0.3 1.4 -0.7
Medication: Lisinopril 0.4 0.6 1.2 -0.9 -0.9 -0.1 -0.2 1.1 0.5 -0.9 -0.9 -0.7
Medication: Atorvastatin 1.4 1.7 3.7 1.3 0.5 -0.1 1.8 0.2 0.5 1.8 1.9 1.8
Illnesses of father: High blood pressure 0.3 0.3 1.1 0.7 0.7 -0.3 -1.1 -0.2 -0.2 -0.2 0.7 0.2
Alcohol drinker status: Never 0.4 0.4 1.5 -0.4 1.1 -0.1 0.3 -1.2 -0.8 0.6 0.1 0.1
Ever smoked 1.4 2.4 6.4 2.5 1.3 -1.3 2.2 0.5 0.9 0.7 1.7 1.6
Basal metabolic rate 0.1 0.4 1.1 0.2 -0.2 -0.9 -1.0 0.3 -0.4 -1.1 0.2 -0.2
Leg fat percentage (left) 0.7 2.4 8.0 -2.7 -0.9 0.2 -2.8 -0.3 -1.3 0.7 -1.8 -0.2
Arm fat-free mass (left) 0.1 0.5 1.5 0.7 0.1 -1.0 -1.2 0.2 -0.3 -0.6 0.8 0.3
Number of operations (self-reported) 0.7 1.0 3.5 -1.0 0.5 0.3 -0.8 1.0 0.2 -0.8 -1.9 -1.3
Average weekly beer plus cider intake 1.0 1.4 3.5 -0.6 1.9 1.1 -1.8 -1.4 -1.2 0.7 -0.8 0.6
Irritability 1.0 1.6 4.8 -1.9 -1.1 -0.4 -0.3 0.7 0.2 -1.8 -1.1 -2.2
Risk taking 1.0 1.4 6.1 2.5 0.1 -1.0 0.2 -0.2 -0.7 1.0 1.7 1.0
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.6 0.9 -1.0 0.9 0.4 1.3 1.2 -0.5 -0.0 -0.5
Fractured/broken bones in last 5 years 0.7 0.9 3.0 1.7 0.9 -0.0 1.3 -0.4 -0.1 0.3 1.3 0.6
Age started oral contraceptive pill 1.7 2.2 5.5 -1.3 -0.7 1.1 -0.8 1.4 1.2 -2.1 -1.3 -2.3
Diastolic blood pressure, automated reading 0.6 1.7 4.8 -1.7 1.3 -1.6 -2.2 -0.1 -0.6 -1.0 -0.9 -1.0
Ever depressed for a whole week 0.8 0.9 3.0 1.1 0.3 -0.6 1.4 0.3 0.0 0.5 1.7 1.2
Unable to work because of sickness or disability 1.1 1.5 7.0 0.8 0.3 -0.9 -0.0 -0.7 -0.3 1.3 2.6 1.5
Commuting to job workplace: Cycle 0.7 0.9 3.1 1.5 0.0 -0.8 1.8 0.1 0.7 -0.2 0.6 1.1
Myopia 0.5 0.8 2.0 1.4 0.2 -1.4 1.2 0.6 0.8 -0.5 0.3 0.3
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.3 1.4 -0.3 -0.0 0.9 -0.7 -0.3 1.0 1.5 0.9
Cholesterol lowering medication 0.4 0.6 1.8 -0.2 0.7 -0.8 -0.2 1.0 0.8 -1.4 -0.0 -1.0
Medication: Omeprazole (e.g. Zanprol) 3.9 4.7 9.8 -2.4 -1.8 0.4 -2.6 2.1 1.3 -2.6 -2.0 -3.1
Pain experienced in last month 0.4 0.7 1.5 -0.8 -1.2 0.0 -1.0 -0.1 -0.0 -0.7 -1.0 -1.2
Supplements: Calcium 0.5 0.6 1.2 -0.8 0.3 1.1 -0.0 -0.6 -1.1 0.9 -0.9 0.3
Basal cell carcinoma (self-reported) 2.6 3.1 6.7 1.1 2.2 -1.3 0.6 2.6 1.8 -2.2 0.5 -2.0
Heart attack/myocardial infarction (self-reported) 0.4 0.6 2.4 -0.3 -0.2 -0.2 0.5 1.0 1.6 -0.9 0.0 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.2 0.2 -0.0 -1.1 0.9 1.0 0.1 -0.7 -0.5 -1.1
Heart disease (siblings) 1.0 1.3 2.4 -1.2 -0.3 0.1 -0.8 1.3 0.8 -1.4 -1.5 -1.5
Alcohol drinker status: Previous 0.4 0.5 2.1 1.4 -0.5 0.1 1.0 -0.0 0.1 0.4 -0.2 0.9
Pack years of smoking 0.5 0.7 1.4 0.1 -0.9 0.5 1.1 -0.8 -0.5 1.2 0.1 1.2
Impedance of whole body 0.2 1.3 3.1 -1.7 -0.9 1.8 1.0 0.7 1.0 0.5 -1.2 -0.7
Leg fat mass (left) 0.5 2.1 8.8 -2.0 -0.8 0.3 -3.0 -0.6 -1.5 0.4 -1.5 0.0
Arm predicted mass (left) 0.1 0.4 1.1 0.5 -0.2 -0.9 -1.1 0.4 -0.2 -0.8 0.7 0.0