[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr15:98,944,630-100,972,747

Best TWAS P=1.8e-22 · Best GWAS P=1.18e-20 conditioned to 0.0283

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Thyroid Carcinoma	SYNM	0.06	0.04	blup	17	0.03	2.7e-04	-8.39	9.8	1.8e-22	-0.84	0.00	0.99	TRUE
7	GTEx	Breast Mammary Tissue (Female)	LYSMD4	0.22	0.00	lasso	5	0.03	3.5e-02	4.19	5.8	6.2e-09	0.01	0.10	0.23	TRUE
5	GTEx	Brain Cerebellum	SYNM	0.19	0.08	enet	10	0.08	2.7e-03	5.08	8.2	3.2e-16	-0.51	0.18	0.34	FALSE
9	GTEx	Nerve Tibial	RP11-6O2.4	0.20	0.11	lasso	9	0.14	2.5e-10	-7.46	8.0	1.2e-15	-0.75	0.89	0.11	FALSE
8	GTEx	Nerve Tibial	SYNM	0.24	0.21	lasso	7	0.20	1.9e-14	-7.46	8.0	1.3e-15	-0.76	0.98	0.02	FALSE
12	METSIM	Adipose	SYNM	0.14	0.12	lasso	8	0.14	5.1e-21	-7.49	7.8	6.4e-15	-0.66	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SYNM	0.12	0.08	blup	17	0.07	3.2e-04	-8.39	7.4	1.5e-13	-0.62	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SYNM	0.07	0.08	enet	12	0.06	1.7e-07	-4.66	6.7	2.9e-11	-0.47	0.98	0.02	FALSE
13	YFS	Blood	LRRC28	0.18	0.06	enet	41	0.13	7.4e-40	1.42	6.5	8.3e-11	-0.48	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SYNM	0.08	0.03	enet	4	0.05	2.1e-06	-8.39	6.4	1.8e-10	-0.72	0.00	0.99	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYNM	0.02	0.02	blup	17	0.01	4.3e-04	5.01	6.3	2.3e-10	-0.33	0.04	0.04	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SYNM	0.13	0.03	enet	5	0.07	2.7e-04	-8.39	6.2	7.3e-10	-0.66	0.00	0.83	FALSE
2	GTEx	Adipose Subcutaneous	SYNM	0.12	0.09	enet	10	0.10	2.1e-08	5.52	6.1	8.8e-10	-0.28	0.99	0.01	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TTC23	0.09	-0.01	blup	67	0.01	8.1e-02	-2.90	6.0	1.9e-09	-0.55	0.01	0.84	FALSE
3	GTEx	Adipose Subcutaneous	RP11-6O2.4	0.13	0.10	lasso	4	0.10	1.6e-08	5.01	5.7	1.3e-08	-0.24	0.99	0.01	FALSE
11	GTEx	Thyroid	SYNM	0.11	0.03	lasso	3	0.02	8.1e-03	5.63	5.7	1.3e-08	-0.27	0.14	0.39	FALSE
4	GTEx	Adipose Visceral Omentum	SYNM	0.19	0.07	lasso	4	0.05	9.7e-04	5.01	5.6	1.7e-08	-0.24	0.92	0.01	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTC23	0.06	0.00	blup	67	0.02	4.1e-03	-0.25	5.6	2.7e-08	-0.30	0.02	0.07	FALSE
6	GTEx	Brain Cerebellum	RP11-6O2.4	0.23	0.15	lasso	13	0.12	1.8e-04	5.08	5.5	3.4e-08	-0.24	0.44	0.11	FALSE
10	GTEx	Skin Sun Exposed Lower leg	LYSMD4	0.23	0.11	enet	20	0.18	7.5e-15	4.19	5.3	9.1e-08	-0.05	1.00	0.00	FALSE