Best TWAS P=1.8e-22 · Best GWAS P=1.18e-20 conditioned to 0.0283
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SYNM | 0.07 | 0.08 | enet | 12 | 0.06 | 1.7e-07 | -4.66 | 6.7 | 2.9e-11 | -0.47 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SYNM | 0.12 | 0.09 | enet | 10 | 0.10 | 2.1e-08 | 5.52 | 6.1 | 8.8e-10 | -0.28 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RP11-6O2.4 | 0.13 | 0.10 | lasso | 4 | 0.10 | 1.6e-08 | 5.01 | 5.7 | 1.3e-08 | -0.24 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | SYNM | 0.19 | 0.07 | lasso | 4 | 0.05 | 9.7e-04 | 5.01 | 5.6 | 1.7e-08 | -0.24 | 0.92 | 0.01 | FALSE |
| 5 | GTEx | Brain Cerebellum | SYNM | 0.19 | 0.08 | enet | 10 | 0.08 | 2.7e-03 | 5.08 | 8.2 | 3.2e-16 | -0.51 | 0.18 | 0.34 | FALSE |
| 6 | GTEx | Brain Cerebellum | RP11-6O2.4 | 0.23 | 0.15 | lasso | 13 | 0.12 | 1.8e-04 | 5.08 | 5.5 | 3.4e-08 | -0.24 | 0.44 | 0.11 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | LYSMD4 | 0.22 | 0.00 | lasso | 5 | 0.03 | 3.5e-02 | 4.19 | 5.8 | 6.2e-09 | 0.01 | 0.10 | 0.23 | TRUE |
| 8 | GTEx | Nerve Tibial | SYNM | 0.24 | 0.21 | lasso | 7 | 0.20 | 1.9e-14 | -7.46 | 8.0 | 1.3e-15 | -0.76 | 0.98 | 0.02 | FALSE |
| 9 | GTEx | Nerve Tibial | RP11-6O2.4 | 0.20 | 0.11 | lasso | 9 | 0.14 | 2.5e-10 | -7.46 | 8.0 | 1.2e-15 | -0.75 | 0.89 | 0.11 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | LYSMD4 | 0.23 | 0.11 | enet | 20 | 0.18 | 7.5e-15 | 4.19 | 5.3 | 9.1e-08 | -0.05 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Thyroid | SYNM | 0.11 | 0.03 | lasso | 3 | 0.02 | 8.1e-03 | 5.63 | 5.7 | 1.3e-08 | -0.27 | 0.14 | 0.39 | FALSE |
| 12 | METSIM | Adipose | SYNM | 0.14 | 0.12 | lasso | 8 | 0.14 | 5.1e-21 | -7.49 | 7.8 | 6.4e-15 | -0.66 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | LRRC28 | 0.18 | 0.06 | enet | 41 | 0.13 | 7.4e-40 | 1.42 | 6.5 | 8.3e-11 | -0.48 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SYNM | 0.02 | 0.02 | blup | 17 | 0.01 | 4.3e-04 | 5.01 | 6.3 | 2.3e-10 | -0.33 | 0.04 | 0.04 | FALSE |
| 15 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SYNM | 0.12 | 0.08 | blup | 17 | 0.07 | 3.2e-04 | -8.39 | 7.4 | 1.5e-13 | -0.62 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TTC23 | 0.09 | -0.01 | blup | 67 | 0.01 | 8.1e-02 | -2.90 | 6.0 | 1.9e-09 | -0.55 | 0.01 | 0.84 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SYNM | 0.13 | 0.03 | enet | 5 | 0.07 | 2.7e-04 | -8.39 | 6.2 | 7.3e-10 | -0.66 | 0.00 | 0.83 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SYNM | 0.08 | 0.03 | enet | 4 | 0.05 | 2.1e-06 | -8.39 | 6.4 | 1.8e-10 | -0.72 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TTC23 | 0.06 | 0.00 | blup | 67 | 0.02 | 4.1e-03 | -0.25 | 5.6 | 2.7e-08 | -0.30 | 0.02 | 0.07 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | SYNM | 0.06 | 0.04 | blup | 17 | 0.03 | 2.7e-04 | -8.39 | 9.8 | 1.8e-22 | -0.84 | 0.00 | 0.99 | TRUE |