TWAS hub - SYNM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0230	3.8e-04	0.075	0.025	0.057	0.045	0.055	1.9e-09	4.6e-04	1.7e-07	2.8e-06	2.9e-07
2	GTEx	Adipose Subcutaneous	0.1160	0.0340	3.4e-05	0.089	NA	0.098	NA	0.092	1.0e-07	NA	2.1e-08	NA	6.0e-08
3	GTEx	Adipose Visceral Omentum	0.1900	0.0560	7.6e-05	0.069	NA	0.047	NA	0.053	1.8e-04	NA	1.8e-03	NA	9.7e-04
4	GTEx	Adrenal Gland	0.2629	0.0890	2.5e-03	0.203	NA	0.079	NA	0.187	7.8e-08	NA	8.8e-04	NA	2.9e-07
5	GTEx	Artery Tibial	0.1001	0.0315	2.1e-04	0.048	NA	0.050	NA	0.052	1.1e-04	NA	8.7e-05	NA	6.7e-05
6	GTEx	Brain Cerebellum	0.1860	0.0720	1.0e-02	0.082	NA	0.078	NA	0.074	2.0e-03	NA	2.7e-03	NA	3.2e-03
7	GTEx	Brain Putamen basal ganglia	0.2540	0.0990	7.6e-03	0.031	NA	-0.001	NA	0.016	6.2e-02	NA	3.4e-01	NA	1.4e-01
8	GTEx	Cells Transformed fibroblasts	0.1570	0.0480	3.3e-05	0.123	NA	0.074	NA	0.105	1.8e-09	NA	3.4e-06	NA	3.0e-08
9	GTEx	Nerve Tibial	0.2401	0.0494	1.7e-09	0.212	NA	0.202	NA	0.204	5.2e-15	NA	2.8e-14	NA	1.9e-14
10	GTEx	Pancreas	0.2170	0.0710	2.5e-03	0.142	NA	0.194	NA	0.188	1.4e-06	NA	1.3e-08	NA	2.1e-08
11	GTEx	Thyroid	0.1140	0.0520	6.6e-03	0.030	NA	0.014	NA	0.022	2.1e-03	NA	2.9e-02	NA	8.1e-03
12	METSIM	Adipose	0.1365	0.0286	1.5e-15	0.117	0.115	0.132	0.132	0.145	3.8e-17	8.4e-17	3.6e-19	3.6e-19	5.1e-21
13	NTR	Blood	0.0740	0.0165	6.3e-14	0.069	0.052	0.062	0.062	0.070	3.6e-21	1.7e-16	2.4e-19	2.7e-19	1.3e-21
14	YFS	Blood	0.2590	0.0289	0.0e+00	0.340	0.326	0.341	0.350	0.350	2.7e-116	1.8e-110	1.6e-116	4.0e-120	2.2e-120
15	TCGA	Breast Invasive Carcinoma	0.0243	0.0159	1.7e-03	0.016	0.015	0.013	NA	0.012	2.2e-04	4.3e-04	1.0e-03	NA	1.3e-03
16	TCGA	Cervical Squamous Cell Carcinoma	0.1230	0.0550	8.7e-06	0.081	0.067	0.062	NA	0.061	8.1e-05	3.2e-04	5.4e-04	NA	5.7e-04
17	TCGA	Liver Hepatocellular Carcinoma	0.1280	0.0680	1.9e-03	0.030	0.054	0.072	NA	0.033	1.4e-02	1.5e-03	2.7e-04	NA	1.1e-02
18	TCGA	Lung Squamous Cell Carcinoma	0.0836	0.0458	1.9e-05	0.025	0.040	0.050	NA	0.033	6.2e-04	2.3e-05	2.1e-06	NA	1.1e-04
19	TCGA	Thyroid Carcinoma	0.0630	0.0360	7.3e-04	0.038	0.034	0.032	NA	0.027	1.2e-04	2.7e-04	4.2e-04	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Lung FEV1/FVC ratio	7.0	35.7	95.1	6.7	6.1	5.6	-1.0	-1.3	8.2	4.7	3.4	8.0	-3.4	5.7	7.8	3.3	3.7	6.3	7.4	6.2	6.4	9.8
Forced expiratory volume in 1-second (FEV1), Best measure	4.6	14.8	37.2	3.5	5.2	5.0	-0.8	1.1	5.8	3.8	0.6	3.9	-3.1	4.4	4.7	0.7	1.0	4.6	5.5	2.3	2.1	6.1
Forced expiratory volume in 1-second (FEV1)	3.7	12.3	31.0	3.4	4.9	4.9	-0.1	1.2	5.6	3.9	0.4	3.2	-2.0	4.2	4.3	0.3	0.5	4.8	4.5	1.4	1.4	5.3
Myopia	3.7	5.3	10.0	-2.5	-3.2	-3.1	1.0	-2.2	-2.9	-3.2	-1.8	-0.9	1.0	-3.1	-3.2	-1.2	-1.3	-2.4	-3.0	-1.2	-0.8	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	10.4	-2.0	-2.9	-2.8	0.3	-0.5	-3.2	-2.4	-0.3	-1.6	1.4	-2.3	-3.1	-0.8	-0.7	-2.7	-2.5	-0.2	-0.6	-2.9
High blood pressure (siblings)	3.1	4.5	9.6	-2.1	-1.5	-1.6	2.4	0.6	-2.5	-1.1	-2.1	-2.4	3.1	-1.4	-2.9	-2.3	-2.5	-0.8	-2.9	-1.6	-2.0	-2.5
Average weekly fortified wine intake	2.8	3.3	8.0	1.7	2.5	2.7	-0.9	1.3	2.8	2.5	1.4	0.9	-0.9	2.4	2.5	1.1	1.0	2.3	1.7	-0.1	0.0	1.6
Leg fat percentage (left)	2.8	10.2	21.6	-2.8	-4.5	-4.4	1.6	-1.6	-4.7	-3.4	-1.4	-2.3	2.7	-3.7	-4.3	-1.1	-1.5	-3.5	-4.6	-1.5	-1.4	-4.5
Maternal smoking around birth	2.6	3.7	8.5	-2.5	-2.6	-2.7	-0.3	-0.5	-2.6	-2.6	-0.8	-1.8	0.2	-2.9	-2.4	-0.1	-0.1	-2.3	-2.2	-1.3	-1.0	-2.3
Illnesses of siblings	2.6	3.7	6.9	1.7	2.0	2.1	-1.4	0.5	2.5	1.9	1.9	1.7	-1.9	1.9	2.6	1.7	1.8	1.6	2.6	1.5	1.5	2.6
Pulse rate, automated reading	2.6	8.4	27.2	-2.5	-1.5	-1.6	4.9	0.4	-2.2	-2.5	-3.3	-2.6	5.2	-2.3	-4.0	-3.0	-3.2	0.8	-3.9	-1.6	-2.4	-1.8
Body fat percentage	2.5	9.9	22.8	-2.3	-4.4	-4.3	1.1	-1.4	-4.7	-3.5	-0.9	-2.6	2.5	-3.8	-4.1	-0.8	-1.1	-3.9	-4.2	-1.4	-1.4	-4.8
Leg fat percentage (right)	2.5	9.1	19.7	-2.7	-4.1	-3.9	1.5	-1.3	-4.3	-3.1	-1.4	-2.4	2.5	-3.4	-4.2	-1.3	-1.6	-3.2	-4.4	-1.9	-1.7	-4.4
Alcohol drinker status: Never	2.5	3.0	7.7	2.2	2.6	2.4	0.1	1.1	2.7	2.1	0.6	1.3	-0.2	2.1	2.0	0.5	0.4	2.8	1.7	0.5	0.4	2.2
Forced vital capacity (FVC), Best measure	2.4	8.8	22.4	2.4	4.7	4.7	0.1	2.4	4.5	3.7	-0.6	1.6	-1.6	3.9	3.2	-0.5	-0.4	3.9	4.0	0.5	0.0	3.9
Leg fat mass (left)	2.3	8.8	18.6	-2.3	-4.2	-3.9	1.6	-1.8	-4.3	-3.4	-1.4	-2.2	2.4	-3.6	-3.9	-0.9	-1.4	-3.7	-3.9	-1.5	-1.3	-4.3
Leg fat mass (right)	2.2	8.4	19.1	-2.1	-4.1	-3.8	1.5	-1.7	-4.2	-3.2	-1.4	-2.2	2.2	-3.5	-3.7	-0.9	-1.4	-3.6	-3.8	-1.7	-1.4	-4.4
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	7.9	0.1	2.4	2.3	1.2	1.7	1.6	2.8	-1.6	-0.0	0.1	2.8	1.0	-2.0	-1.6	2.0	0.9	-0.7	-1.1	1.3
Arm fat percentage (left)	2.2	8.8	22.8	-1.9	-4.1	-3.9	1.3	-1.3	-4.3	-3.1	-1.0	-2.6	2.5	-3.5	-3.8	-0.9	-1.3	-3.8	-3.9	-1.6	-1.5	-4.8
Breast Cancer	2.1	5.0	10.4	2.7	1.3	0.9	-3.0	-0.4	1.4	1.0	2.9	2.4	-2.9	1.3	2.9	2.7	2.7	0.0	3.2	2.5	2.3	2.1
Supplements: Vitamin C	2.1	2.5	7.2	0.8	2.6	2.7	0.7	2.6	2.1	2.0	-0.0	-0.9	0.2	2.0	1.5	-0.1	-0.1	2.4	1.1	-0.2	-0.5	1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.8	2.0	1.2	1.3	-1.8	0.7	1.3	1.0	2.2	0.9	-1.5	1.1	1.7	2.1	2.1	0.1	2.1	1.6	1.2	1.1
Alzheimer’s Disease (in mother)	2.0	2.4	5.8	-2.0	-0.9	-1.1	1.3	-0.2	-1.3	-0.6	-1.9	-1.2	1.3	-0.7	-2.3	-1.8	-1.6	-0.3	-2.4	-2.2	-2.0	-1.7
Trunk fat percentage	2.0	8.1	20.2	-1.7	-3.9	-3.8	0.9	-1.1	-4.3	-3.2	-0.6	-2.7	2.4	-3.5	-3.8	-0.7	-1.0	-3.6	-3.8	-1.1	-1.3	-4.5
Supplements: Glucosamine	2.0	2.7	6.3	-1.3	0.4	0.7	1.8	1.0	-0.2	1.4	-2.3	-1.9	1.4	0.9	-1.3	-2.2	-2.4	-0.2	-1.3	-2.5	-2.4	-2.0
Diabetes (self-reported)	2.0	3.0	7.2	1.0	-2.7	-2.5	-1.2	-2.6	-1.8	-2.6	1.5	0.7	-0.1	-2.6	-0.7	1.7	1.4	-2.3	-0.9	0.3	0.8	-1.7
Arm fat percentage (right)	2.0	8.0	22.2	-1.9	-3.8	-3.5	1.3	-1.1	-4.0	-2.7	-1.1	-2.6	2.4	-3.1	-3.7	-1.0	-1.4	-3.5	-3.8	-1.9	-1.7	-4.7
Whole body fat mass	2.0	8.2	21.3	-1.8	-3.9	-3.7	1.1	-1.3	-4.2	-3.1	-1.0	-2.5	2.1	-3.4	-3.6	-0.8	-1.2	-3.7	-3.7	-1.7	-1.5	-4.6
Forced vital capacity (FVC)	1.9	7.3	19.4	2.0	4.4	4.4	0.2	2.4	4.1	3.5	-0.6	1.1	-1.3	3.5	2.9	-0.6	-0.5	3.8	3.3	-0.1	-0.5	3.3
Fractured/broken bones in last 5 years	1.9	2.4	6.7	2.2	-0.3	-0.4	-2.1	-1.9	0.4	-0.5	2.0	1.7	-1.9	-0.6	1.8	2.6	2.4	-1.0	1.7	0.8	1.5	0.3
Stomach or abdominal pain in last month	1.8	2.2	5.4	2.1	0.7	0.6	-1.8	0.2	1.1	-0.2	2.2	1.1	-1.6	-0.1	2.0	2.3	2.1	-0.0	2.1	1.4	1.4	1.2
Peak expiratory flow (PEF)	1.8	4.2	11.2	2.7	2.2	2.1	0.1	-0.5	2.7	1.5	1.0	2.5	-0.6	2.0	2.7	0.9	1.0	2.6	2.3	2.0	2.1	3.3
Ovarian Cancer	1.7	2.2	6.8	-0.9	-2.4	-2.4	-0.5	-2.6	-1.7	-1.9	-0.1	0.8	-0.3	-2.1	-1.0	0.6	0.1	-2.5	-0.7	0.3	0.9	-1.2
Alcohol intake versus 10 years previously	1.7	2.5	7.0	0.7	-0.9	-0.8	-2.0	-2.5	0.5	-1.3	1.3	2.6	-2.5	-1.0	1.0	1.9	1.9	-0.7	1.2	1.2	1.9	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	5.1	-1.1	-2.3	-2.1	-0.5	-1.1	-1.8	-2.0	0.4	-0.7	0.3	-1.9	-1.3	0.8	0.6	-1.6	-2.1	-0.8	-0.1	-1.7
Medication: Blood pressure	1.7	3.0	8.0	-1.4	-2.7	-2.7	-0.7	-0.9	-2.5	-2.7	0.7	-0.8	0.1	-2.8	-1.8	0.9	1.0	-2.4	-1.5	0.9	0.7	-1.4
Diabetes diagnosed by doctor	1.7	2.8	6.9	-0.0	-2.6	-2.5	-1.5	-1.9	-2.1	-2.3	1.2	0.1	-0.3	-2.4	-1.2	1.5	1.2	-2.4	-1.2	-0.1	0.3	-2.0
Medication: Aspirin	1.7	2.2	5.3	-2.0	-0.6	-0.6	1.1	1.5	-1.3	-0.4	-1.2	-2.3	1.6	-0.5	-1.9	-1.3	-1.4	-0.5	-2.1	-1.6	-1.9	-1.9
Irritable Bowel Disease (IBD)	1.6	3.7	9.6	-2.1	-3.1	-3.1	0.9	-2.1	-2.5	-2.6	-1.3	-0.2	1.1	-2.4	-2.2	-0.4	-0.4	-2.2	-2.6	-0.5	0.4	-1.8
Body mass index (BMI)	1.6	6.6	14.4	-1.6	-3.8	-3.6	1.2	-1.7	-3.7	-3.1	-0.8	-1.6	2.0	-3.4	-3.2	-0.4	-0.9	-3.4	-3.2	-1.1	-0.8	-3.8
Trunk fat mass	1.6	6.8	19.5	-1.4	-3.4	-3.2	1.1	-0.8	-3.8	-2.6	-0.9	-2.6	2.2	-3.0	-3.3	-0.9	-1.3	-3.3	-3.4	-1.6	-1.6	-4.4
Pulse rate	1.6	2.7	8.2	-0.9	-2.4	-2.3	1.5	-1.8	-1.8	-2.9	-0.4	-0.3	1.9	-2.7	-2.0	-0.1	-0.1	-1.0	-2.2	-0.3	-0.1	-1.4
Medication: Lansoprazole	1.6	1.8	6.0	-0.6	-2.4	-2.1	-0.4	-0.6	-2.1	-1.8	0.5	-0.8	0.2	-2.0	-1.5	0.2	0.6	-2.1	-1.2	0.4	0.2	-1.5
Pulse wave reflection index	1.6	2.0	7.0	-0.7	2.1	2.0	-0.6	2.6	0.9	2.5	-0.7	-1.0	-0.9	2.4	0.7	-1.2	-0.7	1.3	1.1	-0.4	-0.9	0.9
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	7.1	0.8	2.5	2.5	0.8	0.5	2.5	2.2	-0.9	1.1	-0.3	2.4	1.8	-0.8	-0.9	2.7	1.2	-0.9	-0.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	10.8	1.7	2.1	2.2	0.3	0.3	2.8	1.6	0.3	2.0	-0.7	2.0	2.0	0.5	0.5	2.6	2.0	1.8	1.7	3.3
Number of treatments/medications taken	1.5	2.7	6.1	-1.9	-1.9	-1.9	0.2	1.0	-2.4	-1.5	-0.3	-2.2	1.2	-1.7	-2.4	-0.5	-0.5	-1.9	-2.3	-0.6	-1.1	-2.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.9	1.1	1.6	1.5	-1.1	0.6	1.7	1.7	0.5	1.1	-1.5	2.0	1.6	0.5	0.7	0.9	1.8	0.6	0.6	1.4
Medication: Seretide 50 evohaler	1.5	1.7	4.7	-1.6	-1.1	-0.9	0.5	0.3	-1.3	-0.8	-1.2	-1.7	0.7	-0.9	-1.5	-0.7	-1.2	-1.3	-1.8	-1.8	-1.5	-2.2
Medication: Aspirin	1.5	1.9	5.1	-1.7	-0.5	-0.6	1.2	1.5	-1.2	-0.2	-1.1	-2.3	1.8	-0.4	-1.7	-1.2	-1.2	-0.5	-2.1	-1.4	-1.7	-1.8
Knee pain experienced in last month	1.5	2.4	4.4	-2.0	-1.3	-1.1	1.4	0.1	-1.7	-0.5	-2.1	-1.7	1.3	-0.7	-2.0	-1.8	-2.0	-1.1	-2.0	-1.4	-1.2	-1.8
Ever had bowel cancer screening	1.5	1.8	4.4	0.8	1.8	1.9	1.6	1.8	1.5	2.0	-0.4	-0.4	1.6	2.0	0.5	-1.2	-0.9	2.1	-0.1	-0.2	-0.5	0.7
Arm fat mass (left)	1.5	6.0	16.0	-1.3	-3.4	-3.1	1.3	-1.3	-3.5	-2.6	-1.1	-2.0	2.0	-2.9	-3.0	-0.7	-1.2	-3.3	-3.1	-1.5	-1.2	-4.0
Number of operations (self-reported)	1.5	2.3	7.0	-0.5	-2.1	-2.2	0.8	-0.9	-1.9	-2.6	0.1	-1.0	1.7	-2.4	-1.7	0.7	0.5	-1.0	-2.4	0.2	0.1	-1.1
Bipolar Disorder or Schizophrenia	1.4	3.3	8.7	-2.0	0.1	-0.0	3.0	1.7	-0.7	-1.0	-2.3	-1.9	2.8	-0.3	-2.2	-2.2	-2.4	1.3	-2.4	-1.3	-1.8	-0.6
Alzheimer’s Disease (in father)	1.4	1.5	3.4	0.9	0.7	0.5	-1.3	-0.9	1.0	0.7	1.3	1.8	-1.8	0.8	1.6	1.4	1.6	-0.0	1.6	1.1	1.4	1.4
Coronary Artery Disease (CAD)	1.4	1.6	4.8	-1.0	-1.1	-0.7	1.4	-0.1	-1.0	-0.8	-2.2	-1.3	1.2	-0.9	-1.3	-1.3	-1.8	-0.6	-1.5	-1.5	-1.2	-1.7
Lupus	1.4	2.1	5.3	2.1	-1.0	-1.1	-1.2	-1.4	-0.7	-0.8	2.3	1.4	-0.3	-0.9	0.4	2.1	1.8	-1.9	0.9	2.2	2.0	-0.2
Number of incorrect matches in round	1.4	2.3	7.4	-1.3	0.2	0.3	0.7	2.6	-0.8	0.8	-0.8	-2.7	1.3	0.2	-1.5	-1.6	-1.4	0.1	-1.6	-2.0	-2.6	-1.8
Arm fat mass (right)	1.4	5.8	16.2	-1.3	-3.2	-2.9	1.4	-1.1	-3.4	-2.4	-1.1	-2.2	2.2	-2.7	-3.0	-0.9	-1.3	-3.1	-3.1	-1.6	-1.4	-4.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.4	2.2	1.1	1.4	-1.2	-0.2	2.1	1.2	1.4	1.5	-1.6	0.9	2.5	1.7	1.6	0.5	2.1	0.7	1.2	1.3
Eye problems/disorders: Cataract	1.4	1.7	4.4	1.4	1.2	1.2	-0.1	-0.8	1.7	0.8	0.1	2.1	-0.4	1.3	1.3	0.3	0.3	1.2	1.8	1.8	1.5	2.1
Ever depressed for a whole week	1.4	1.7	3.6	1.2	0.8	0.8	-1.8	-0.6	1.3	0.9	1.6	1.6	-1.9	1.0	1.6	1.0	1.3	0.4	1.7	1.3	1.5	1.5
Unable to work because of sickness or disability	1.4	1.8	4.7	-2.1	-1.0	-1.3	0.5	1.0	-1.9	-1.0	-0.9	-2.0	1.0	-1.1	-2.2	-1.3	-0.9	-0.5	-2.0	-0.7	-1.0	-1.2
Bipolar Disorder (2018)	1.3	2.1	7.3	-0.9	-0.8	-0.9	2.7	0.2	-0.8	-1.5	-1.6	-1.0	2.6	-1.0	-1.5	-1.3	-1.5	0.8	-2.5	-1.0	-0.9	-0.7
Primary Biliary Cirrhosis	1.3	1.8	4.2	-2.0	-0.7	-0.5	1.6	-0.1	-1.2	-0.3	-2.1	-1.4	1.3	-0.1	-1.7	-1.5	-1.6	-0.1	-1.9	-1.7	-1.4	-1.2
Medication: Metformin	1.3	1.9	5.5	-0.3	-2.3	-1.8	0.1	-1.4	-1.7	-1.6	-0.2	-0.5	0.7	-1.7	-1.5	-0.3	-0.2	-1.7	-1.9	-1.1	-0.6	-2.3
Number of live births	1.3	1.9	10.0	-0.3	0.4	0.3	3.2	0.5	-0.0	0.7	-2.1	-0.5	2.4	0.7	-0.9	-2.1	-2.1	1.1	-1.2	-0.9	-0.8	-0.2
Number of children fathered	1.3	1.5	3.5	-1.6	-0.4	-0.3	1.0	0.9	-1.1	0.2	-1.3	-1.9	1.2	-0.0	-1.6	-1.4	-1.5	-0.3	-1.6	-1.3	-1.6	-1.5
Mood swings	1.3	2.3	6.9	0.8	-1.7	-1.6	-1.7	-1.5	-1.2	-1.5	2.6	0.2	-0.7	-1.4	-0.1	2.6	2.3	-1.7	-0.2	1.5	1.6	-0.6
Medication: Lisinopril	1.3	1.7	5.0	-1.9	-1.9	-1.9	-1.2	-1.5	-1.4	-2.2	-0.2	0.1	-1.4	-2.0	-1.1	0.3	0.4	-1.4	-1.1	-0.7	-0.2	-0.6
Ulcerative Colitis (UC)	1.2	2.3	6.6	-0.8	-2.6	-2.5	0.3	-2.3	-2.0	-2.2	0.1	0.3	0.8	-2.0	-1.5	0.5	0.4	-2.1	-1.7	0.3	0.7	-1.4
Age at First Birth	1.2	1.8	5.0	-2.2	-1.6	-1.5	-0.6	-0.0	-1.8	-1.8	-0.6	-0.9	-0.5	-1.5	-1.6	-0.3	-0.4	-1.8	-1.5	-1.2	-1.3	-1.6
Waist Hip Ratio (WHR)	1.2	5.5	13.0	1.4	3.5	3.6	-0.5	2.3	3.6	2.6	0.6	1.1	-1.3	2.8	3.0	0.4	0.4	3.2	3.0	0.9	0.5	3.3
Type 2 Diabetes (T2D) (2018)	1.2	2.2	7.0	1.4	-1.9	-1.7	-1.7	-2.6	-1.0	-1.2	1.9	1.4	-0.9	-1.3	0.2	1.9	1.9	-1.6	-0.1	0.6	1.4	-0.7
Serious illness, injury or assault to yourself	1.2	1.5	3.1	-1.2	-1.6	-1.3	-0.1	-0.4	-1.8	-1.6	-0.5	-1.6	0.5	-1.7	-1.8	-0.2	-0.3	-1.0	-1.4	-1.2	-0.9	-1.5
Hearing difficulty/problems with background noise	1.2	2.0	7.5	0.3	1.8	1.9	1.0	2.7	1.1	1.8	-0.4	-1.8	1.1	1.7	0.3	-0.9	-1.0	1.9	-0.3	-1.3	-1.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.5	0.1	-1.5	-1.6	-0.9	-0.5	-1.4	-1.7	1.9	-0.5	0.5	-1.7	-1.0	1.4	1.5	-1.2	-1.2	0.8	0.5	-0.9
Medication for pain relief, constipation, heartburn	1.2	2.0	4.9	1.8	1.2	1.3	-1.4	-0.5	1.6	1.1	1.3	1.6	-1.8	1.1	2.2	1.2	1.3	0.6	2.1	0.8	1.1	1.6
Long-standing illness, disability or infirmity	1.2	1.9	7.1	-1.1	-0.3	-0.3	0.3	2.1	-1.2	0.1	-0.5	-2.7	1.1	-0.3	-1.5	-1.0	-1.0	-0.6	-1.7	-1.8	-2.1	-2.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.0	-1.6	-0.3	-0.1	1.2	1.3	-0.9	-0.4	-2.0	-1.7	0.7	-0.1	-1.2	-1.7	-1.6	-0.2	-0.9	-1.5	-1.7	-1.0
Pain experienced in last month	1.2	2.1	5.1	1.5	-0.2	0.0	-2.1	-1.9	1.0	0.1	1.7	2.2	-1.9	-0.0	1.3	1.9	2.0	-0.2	1.3	1.1	1.7	1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	0.6	1.8	1.5	-0.7	0.6	1.6	1.4	0.6	1.1	-0.9	1.5	1.1	0.2	0.3	1.6	1.3	0.5	0.4	1.7
Relative age voice broke	1.1	1.8	3.8	1.8	0.6	0.5	-1.0	-1.0	1.1	0.3	1.7	1.7	-1.0	0.3	1.7	1.9	1.6	0.2	1.8	1.6	1.7	1.2
Had other major operations	1.1	1.4	3.6	0.1	-1.6	-1.9	0.1	-1.0	-1.5	-1.6	1.2	0.2	0.9	-1.4	-0.6	1.3	1.3	-0.9	-1.1	1.5	1.3	-0.1
Heart attack	1.1	1.4	4.5	-1.7	-1.4	-1.7	0.3	-0.1	-1.7	-2.1	-0.1	-1.1	0.8	-1.8	-1.5	-0.1	-0.1	-0.7	-1.8	-0.3	-0.4	-0.9
Pulse wave Arterial Stiffness index	1.1	1.3	6.4	-0.6	1.4	1.5	0.5	2.5	0.5	1.6	-0.5	-1.6	0.7	1.4	0.0	-1.1	-0.7	1.4	-0.3	-0.4	-1.0	0.3
Gout (self-reported)	1.1	1.5	4.0	2.0	0.7	0.7	-1.3	-0.6	1.2	1.4	1.8	1.2	-1.1	1.0	1.8	1.3	1.1	-0.1	1.5	1.0	1.2	0.5
Comparative body size at age 10	1.1	2.9	8.6	-1.8	-1.6	-1.6	0.7	-0.9	-1.7	-1.0	-1.9	-1.1	0.6	-1.4	-2.1	-1.7	-1.8	-2.0	-1.6	-2.5	-1.8	-2.9
Angina (self-reported)	1.1	1.4	4.2	-0.9	0.2	0.1	1.0	1.6	-0.4	-0.5	-1.2	-2.0	1.2	-0.4	-0.9	-1.4	-1.5	0.1	-0.9	-1.8	-2.0	-1.3
Leg pain on walking	1.1	1.3	4.1	-0.6	-1.9	-1.7	-0.3	-1.5	-1.5	-2.0	0.2	-0.1	0.0	-2.0	-1.1	0.8	0.5	-1.4	-1.0	-0.0	0.2	-1.0
Average weekly red wine intake	1.1	1.6	4.2	1.5	1.6	1.8	0.3	-0.1	2.0	1.9	0.2	1.2	-0.3	2.0	1.7	-0.3	-0.0	1.3	1.4	0.2	0.5	1.2
Handedness (chirality/laterality): Left-handed	1.1	1.4	5.0	-1.1	-0.4	-0.6	1.9	1.0	-1.0	-0.8	-1.2	-1.5	2.2	-0.5	-1.4	-1.2	-1.3	0.6	-1.5	-0.4	-1.0	-0.6
Risk taking	1.1	1.6	4.7	1.0	2.0	1.9	1.3	1.8	1.8	1.2	-0.2	-0.3	1.0	1.4	1.0	-0.2	-0.7	2.2	0.5	-0.1	-0.3	1.2
Commuting to job workplace: Cycle	1.1	1.4	3.6	-0.8	-1.6	-1.6	-0.4	-0.6	-1.7	-1.6	0.1	-0.6	0.3	-1.8	-1.5	0.2	0.1	-1.9	-1.2	-0.4	-0.4	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.8	-0.3	-1.2	-1.4	-1.9	-1.1	-0.9	-1.5	1.3	0.3	-1.3	-1.7	-0.5	1.3	1.5	-1.4	-0.1	-0.0	0.0	-0.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.9	-1.5	-1.6	-1.8	0.0	-0.4	-1.7	-2.2	0.1	-0.9	0.6	-1.9	-1.4	0.1	0.2	-0.9	-1.7	-0.2	-0.2	-0.9
Body Mass Index (BMI) (2010)	1.0	1.4	3.6	-1.0	-1.0	-1.0	0.8	0.1	-1.5	-0.6	-0.9	-1.4	1.3	-0.8	-1.5	-1.2	-1.1	-0.8	-1.5	-1.3	-1.4	-1.9
HDL Cholesterol	1.0	1.7	7.5	-0.1	-1.9	-1.8	-1.1	-2.7	-1.2	-1.0	0.5	0.9	-1.1	-1.2	-0.5	1.2	1.0	-2.5	-0.3	0.1	0.5	-1.2
High blood pressure (mother)	1.0	1.4	3.1	0.9	-1.3	-1.3	-1.2	-1.2	-0.8	-1.8	1.6	0.7	-0.3	-1.7	-0.5	1.4	1.3	-1.3	0.2	1.2	1.1	-0.4
Noisy workplace	1.0	1.2	4.5	1.2	1.2	1.2	-0.1	0.1	1.4	0.6	0.6	1.3	-0.4	0.9	1.1	0.5	0.6	1.8	1.2	1.2	0.9	2.1
Illnesses of mother	1.0	1.3	2.8	0.1	1.7	1.7	0.7	0.1	1.5	1.4	-1.2	0.8	-0.3	1.5	1.3	-0.8	-0.8	1.4	1.4	-0.1	-0.1	1.5
Breastfed as a baby	1.0	1.3	4.5	-1.0	-1.7	-1.7	-0.3	-1.9	-1.4	-2.1	-0.5	0.4	-0.4	-1.7	-0.9	0.0	0.1	-1.4	-0.9	-0.4	-0.0	-0.7
Migraine (self-reported)	1.0	1.2	3.3	-0.9	-0.8	-0.8	1.6	0.4	-1.0	-0.5	-1.3	-1.2	1.8	-0.5	-1.4	-1.2	-1.3	-0.1	-1.6	-0.8	-0.8	-1.2
Medication: Omeprazole	1.0	1.2	3.9	-0.5	-1.2	-1.4	-2.0	-0.8	-0.8	-1.4	1.3	0.2	-1.3	-1.5	-0.4	1.3	1.5	-1.4	-0.1	-0.1	0.0	-0.9
Asthma (self-reported)	1.0	2.0	4.4	-0.5	0.0	0.2	1.6	1.2	-0.9	0.6	-1.7	-2.1	2.0	0.4	-1.1	-1.7	-2.1	-0.2	-1.3	-1.8	-1.9	-1.9
Financial situation satisfaction	1.0	1.2	3.4	-1.3	-1.2	-1.1	0.5	0.7	-1.1	-1.0	-0.6	-1.5	0.9	-1.1	-1.3	-0.8	-0.8	-0.3	-1.8	-1.3	-1.1	-1.4
Schizophrenia (2018)	0.9	1.8	4.2	-1.8	0.8	0.6	1.6	2.0	-0.2	-0.1	-1.7	-1.7	1.5	0.3	-1.6	-1.8	-1.9	1.1	-1.1	-0.9	-1.6	-0.2
Triglycerides	0.9	1.5	4.5	1.4	1.8	2.1	0.3	0.9	1.8	1.8	0.2	0.2	0.3	1.9	1.1	-0.3	-0.3	2.1	0.7	-0.3	-0.1	1.0
BMI	0.9	5.0	10.7	-1.4	-3.0	-2.9	1.4	-1.3	-3.1	-2.6	-0.9	-1.7	2.3	-2.9	-3.0	-0.7	-1.1	-2.7	-2.7	-0.9	-1.0	-3.3
Hearing difficulty/problems: Yes	0.9	1.4	5.4	-0.9	-0.1	-0.1	1.1	2.1	-0.9	0.1	-0.5	-2.3	1.7	0.1	-1.1	-0.8	-0.8	0.2	-1.6	-1.1	-1.6	-1.4
Vitamin and mineral supplements	0.9	1.2	3.2	1.2	-0.2	-0.2	-1.2	-0.8	0.4	-0.2	1.3	1.5	-1.0	-0.2	1.2	1.2	1.4	-0.8	1.4	1.8	1.6	0.7
Severe depression (siblings)	0.9	1.0	3.6	-0.8	-0.8	-0.6	0.7	-0.1	-0.6	-0.8	-0.9	-0.9	0.8	-0.8	-1.1	-0.6	-0.7	-0.0	-1.6	-1.9	-1.5	-1.3
Birth weight of first child	0.9	1.6	6.6	0.9	1.5	1.8	0.8	0.8	2.1	1.0	-0.0	1.1	0.2	1.1	0.7	-0.6	-0.1	2.6	0.8	1.0	0.9	2.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.9	1.2	0.5	0.5	-0.2	-0.2	1.0	0.2	1.1	1.1	-0.4	0.6	1.0	0.8	0.9	0.8	1.3	1.7	1.7	1.7
Headache pain in last month	0.9	1.5	6.5	-0.2	-0.9	-1.1	2.5	-0.7	-1.0	-1.2	-1.2	-0.5	2.5	-1.1	-1.2	-1.0	-1.2	0.3	-1.6	-0.4	-0.4	-0.6
Glaucoma (self-reported)	0.9	1.0	3.2	-0.5	-0.6	-0.8	1.1	-0.7	-0.9	-0.1	-1.3	-0.9	1.4	-0.3	-0.9	-1.1	-1.1	0.0	-1.8	-1.4	-1.0	-1.2
Health satisfaction	0.9	1.1	4.6	-0.1	0.3	0.4	1.6	1.2	0.2	-0.0	-0.7	-1.5	2.1	0.0	-0.5	-0.8	-1.2	0.6	-1.3	-1.3	-1.5	-1.2
Medication: Allopurinol	0.9	1.2	2.8	1.7	0.5	0.6	-1.5	-0.4	1.2	1.2	1.5	1.2	-1.4	0.9	1.6	1.2	1.2	-0.2	1.2	0.5	0.9	0.4
Number of full sisters	0.9	1.1	3.4	1.4	-0.9	-0.7	-0.9	-1.9	-0.2	-0.6	1.2	1.2	-0.9	-0.5	0.7	1.4	1.4	-1.0	0.6	0.9	1.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.2	0.6	1.7	1.7	0.4	1.8	1.6	0.8	0.3	-0.1	0.1	0.8	0.9	-0.1	-0.1	1.7	1.2	0.4	-0.0	1.4
Ever taken oral contraceptive pill	0.9	1.0	4.1	-0.5	0.9	0.9	2.0	0.9	0.6	0.4	-1.3	-0.6	1.4	0.6	-0.4	-1.4	-1.4	1.4	-0.2	-0.3	-0.6	0.6
Commuting to job workplace: Public transport	0.9	1.1	5.8	2.4	0.9	1.0	0.3	-1.2	1.5	0.3	0.4	1.6	0.1	0.5	1.4	0.6	0.3	0.8	1.4	0.5	0.8	0.8
Bipolar Disorder (2011)	0.8	0.8	2.2	0.1	-1.3	-1.1	1.2	-1.3	-0.8	-1.5	-0.1	0.4	1.3	-1.0	-0.7	0.0	-0.2	-0.1	-1.2	0.5	0.8	-0.2
Smoking Status	0.8	1.8	7.0	-0.6	1.1	1.3	2.7	0.7	1.1	0.6	-2.4	-0.2	1.4	0.9	-0.2	-1.9	-2.0	1.8	-0.4	-0.9	-0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.5	-1.0	-0.6	-0.3	0.4	1.1	-1.0	0.3	-0.5	-1.9	0.9	-0.4	-1.4	-1.1	-0.9	-0.1	-1.7	-1.3	-1.4	-1.4
Angina	0.8	1.1	3.3	-0.6	0.3	0.3	1.0	1.4	-0.2	-0.3	-1.0	-1.8	1.1	-0.1	-0.6	-1.4	-1.4	0.2	-0.8	-1.6	-1.8	-1.1
Supplements: Zinc	0.8	0.9	3.1	-0.7	-0.5	-0.7	-1.7	0.3	-1.0	-0.4	1.1	-0.4	-1.4	-0.7	-0.2	1.4	1.2	-1.8	0.6	0.9	0.3	-0.3
Diabetes (mother)	0.8	1.1	3.1	-1.3	-0.1	-0.3	0.8	0.9	-0.8	0.3	-1.1	-1.5	0.6	0.1	-1.0	-1.3	-1.1	0.3	-1.4	-1.8	-1.6	-0.9
Taking other prescription medications	0.8	1.2	3.2	-1.0	-0.7	-0.6	0.1	0.9	-1.0	-0.6	-0.8	-1.6	0.4	-0.6	-1.5	-1.1	-0.9	-0.9	-1.2	-1.4	-1.6	-1.8
Multivitamins +/- minerals	0.8	1.0	2.4	-1.5	-1.1	-1.0	0.6	-1.1	-1.0	-0.9	-1.2	-0.2	0.3	-0.8	-1.2	-0.9	-1.1	-0.6	-1.2	-1.4	-0.8	-1.0
Sitting height	0.8	5.8	16.8	3.0	3.9	4.1	0.2	2.8	3.2	3.4	0.3	-0.1	-0.6	3.5	2.8	-0.3	-0.5	2.4	3.0	0.1	-0.5	1.8
Waist circumference	0.8	2.8	7.0	-1.2	-1.4	-1.2	1.4	0.3	-1.7	-1.2	-1.5	-2.0	1.7	-1.4	-2.1	-1.2	-1.7	-1.3	-2.2	-1.9	-1.9	-2.7
Hip circumference	0.8	3.4	10.7	-0.7	-1.5	-1.2	1.7	0.3	-2.1	-1.0	-1.6	-2.4	2.1	-1.3	-2.3	-1.4	-1.9	-1.6	-2.3	-2.1	-2.2	-3.3
Asthma	0.8	1.6	3.7	-0.3	0.2	0.4	1.6	1.2	-0.6	0.7	-1.4	-1.8	1.9	0.5	-0.8	-1.4	-1.9	-0.0	-1.1	-1.6	-1.7	-1.6
Medication: Cholesterol lowering	0.8	1.2	3.2	0.9	-1.1	-1.3	-1.0	-0.3	-1.0	-1.0	1.7	0.2	0.1	-1.0	-0.2	1.2	1.4	-1.8	0.2	1.8	1.2	-0.7
Length of working week for main job	0.8	0.9	2.3	0.7	1.5	1.3	-0.1	1.2	0.8	1.4	0.1	0.2	-0.2	1.3	0.6	-0.2	-0.1	0.8	1.5	1.3	0.5	1.4
Hair/balding pattern: Pattern 4	0.8	2.0	6.3	-0.8	-2.3	-2.1	-1.2	-1.5	-2.1	-1.6	0.5	-0.3	-0.5	-2.0	-1.3	0.4	0.5	-2.5	-1.1	0.0	0.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.7	-1.2	-1.3	-1.1	0.3	0.1	-1.2	-1.0	-0.6	-1.0	0.5	-1.3	-1.0	-0.2	-0.7	-1.3	-1.2	-0.9	-0.7	-1.6
Pulse wave peak to peak time	0.8	0.9	4.7	0.9	-0.9	-0.9	-0.5	-2.2	-0.0	-1.1	0.4	1.7	-0.9	-1.0	0.3	1.1	0.6	-1.2	0.7	0.4	0.9	-0.1
Medication: Ibuprofen	0.8	0.9	2.8	-0.5	-0.4	-0.3	1.7	0.5	-0.8	-0.1	-1.2	-1.1	1.6	-0.2	-1.1	-1.1	-1.3	-0.0	-1.2	-0.8	-0.7	-1.1
Overall health rating	0.8	1.7	5.5	-1.4	-0.0	-0.1	0.6	1.6	-1.0	-0.2	-1.1	-2.3	0.9	-0.4	-1.4	-1.5	-1.4	-0.3	-1.1	-1.9	-2.2	-1.7
Qualifications: nursing, teaching	0.8	1.2	3.3	1.1	0.4	0.5	-1.0	-1.2	1.2	0.3	1.0	1.5	-1.4	0.2	1.8	1.4	1.3	0.3	1.3	0.6	1.2	1.2
Number of self-reported non-cancer illnesses	0.8	1.3	5.1	-0.3	-0.2	-0.1	1.0	2.0	-0.9	-0.4	-0.2	-2.3	2.1	-0.3	-1.6	-0.9	-0.8	-0.5	-1.3	-0.0	-1.2	-1.4
Crohns Disease (2017)	0.7	1.6	4.0	-1.7	-1.9	-2.0	0.9	-1.1	-1.6	-1.6	-1.4	-0.2	0.8	-1.3	-1.3	-0.6	-0.6	-1.3	-1.7	-0.3	0.4	-1.0
Prostate Cancer	0.7	1.0	3.3	0.8	-0.4	-0.3	-0.8	-1.2	0.6	-0.7	1.4	1.4	-0.9	-0.4	1.0	1.8	1.7	0.2	0.3	0.8	1.4	0.9
LDL Cholesterol	0.7	1.1	4.1	1.0	1.4	1.5	-0.2	0.2	1.2	2.0	0.2	0.1	-0.5	1.9	1.6	-0.0	0.0	1.1	1.0	-0.1	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.0	-0.3	1.5	1.5	-0.6	1.7	1.3	1.0	-0.1	-0.5	-0.8	1.0	0.7	-0.5	-0.2	1.3	0.7	-0.3	-0.6	0.8
Chronic bronchitis/emphysema (father)	0.7	0.9	2.5	-1.3	-1.3	-1.6	-1.1	-0.6	-1.4	-1.3	-0.1	-0.2	-1.0	-1.2	-0.5	0.1	0.4	-1.3	-0.4	-0.3	-0.1	-0.6
Financial difficulties in last 2 years	0.7	1.0	2.8	0.9	1.7	1.4	-0.3	1.6	1.2	1.2	0.7	-0.2	-0.3	1.2	1.2	0.5	0.3	1.0	1.3	0.5	0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.4	0.9	1.7	1.8	1.0	1.7	1.5	0.9	-0.0	-0.4	1.2	1.2	0.5	-0.5	-0.6	1.7	0.5	-0.1	-0.4	0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	-1.4	-0.2	-0.4	0.8	0.8	-0.7	-0.2	-1.3	-1.2	0.7	-0.2	-0.5	-1.0	-1.1	-0.7	-0.7	-0.9	-1.2	-1.2
Neck or shoulder pain in last month	0.7	1.0	4.7	-0.4	1.2	0.9	1.1	2.2	0.3	0.8	-0.9	-1.4	0.9	1.0	-0.1	-1.2	-1.0	1.3	-0.2	-0.6	-1.2	0.3
Back pain experienced in last month	0.7	1.0	3.5	-0.9	0.7	0.5	0.8	1.9	-0.7	0.6	-1.2	-1.7	0.7	0.6	-0.6	-1.6	-1.3	0.0	0.0	-0.6	-1.4	-0.4
Medication: Gliclazide	0.7	0.8	2.2	-0.8	-1.5	-1.0	-0.3	-0.8	-0.9	-1.3	-0.2	-0.4	0.0	-1.1	-1.0	-0.3	0.1	-0.7	-1.5	-0.9	-0.5	-1.1
Guilty feelings	0.7	1.1	2.7	0.1	-0.5	-0.2	1.6	-0.5	-0.7	-0.1	-1.0	-1.3	1.6	-0.0	-0.7	-1.1	-1.3	-0.3	-1.4	-1.6	-1.1	-1.7
Pack years of smoking	0.7	1.0	2.1	-1.1	-1.5	-1.4	-1.1	-1.3	-0.9	-1.3	0.2	-0.1	-1.1	-1.1	-0.5	0.4	0.6	-1.3	-0.9	-1.0	-0.1	-1.1
Schizophrenia (2014)	0.6	1.4	5.0	-1.8	0.7	0.3	1.0	2.2	-0.6	-0.2	-1.2	-1.5	1.0	0.4	-1.6	-1.5	-1.4	0.8	-1.0	-0.4	-1.4	-0.1
Ulcerative Colitis	0.6	0.8	2.0	-1.1	-1.3	-1.2	1.2	-0.9	-1.0	-0.8	-0.3	-0.1	1.3	-0.9	-1.0	-0.4	-0.4	-0.6	-1.4	-0.2	0.2	-0.8
Blood Eosinophil Count	0.6	4.5	14.8	2.4	2.2	2.1	0.5	0.0	2.9	1.0	0.9	2.2	-0.5	1.5	2.8	1.1	1.0	2.6	2.9	2.6	2.4	3.9
Lung FVC	0.6	3.1	12.1	0.3	2.7	2.7	1.2	1.7	2.8	2.0	-0.7	0.7	0.1	2.0	1.2	-0.8	-0.6	3.5	1.2	0.0	-0.2	2.7
Hand grip strength (left)	0.6	1.5	4.7	0.7	-0.7	-0.5	-1.0	-1.2	0.3	-0.5	1.2	1.7	-1.3	-0.7	1.1	1.6	1.5	-0.7	1.1	2.1	2.2	1.1
Current tobacco smoking	0.6	0.9	2.1	-1.1	0.5	0.6	1.3	1.3	0.1	0.4	-1.5	-1.4	1.1	0.3	-0.8	-1.2	-1.4	0.4	-0.5	-0.9	-1.2	-0.4
Medication: Atenolol	0.6	0.8	2.1	-1.1	-1.1	-1.1	0.6	-0.3	-1.0	-1.0	-0.4	-0.7	0.7	-0.9	-1.1	-0.5	-0.4	-0.7	-1.5	-0.7	-0.5	-1.1
Nervous feelings	0.6	1.2	5.6	2.4	0.3	0.4	-0.2	-1.6	1.1	0.1	0.9	1.9	-0.0	0.4	1.0	0.9	0.9	0.9	0.7	1.0	1.4	1.0
Qualifications: None of the above	0.6	1.2	4.0	-1.5	-1.3	-1.3	1.2	0.1	-1.3	-1.1	-0.7	-0.6	1.3	-1.0	-1.7	-1.1	-0.5	-0.0	-2.0	-0.3	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.6	1.3	1.4	1.5	-0.8	-0.2	1.9	1.1	0.6	1.2	-1.3	1.1	1.8	0.6	0.6	0.6	1.8	0.2	0.6	1.1
Depression (self-reported)	0.6	0.8	1.8	0.8	-1.3	-1.0	1.0	-1.3	-0.9	-1.1	-0.1	-0.2	1.3	-1.0	-0.8	-0.4	-0.5	-0.4	-1.3	-0.1	0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	0.4	1.5	1.5	0.3	1.1	0.9	1.2	-0.4	-0.4	-0.1	1.2	0.7	-0.7	-0.7	1.0	1.1	-0.2	-0.7	0.6
Medication: Paracetamol	0.6	1.0	2.4	-1.3	-1.3	-1.3	0.3	-0.6	-1.5	-1.4	-0.8	-0.5	0.5	-1.1	-1.3	-0.4	-0.6	-1.0	-1.1	-0.3	-0.5	-1.1
Had major operations	0.6	0.7	2.5	0.2	-1.1	-1.0	0.9	-1.3	-0.5	-1.6	-0.5	0.3	1.1	-1.3	-1.2	0.1	-0.1	0.1	-1.2	0.3	0.3	-0.2
Family relationship satisfaction	0.6	0.8	4.1	-0.9	0.5	0.7	0.1	0.5	0.5	1.0	-0.9	-0.6	-0.3	0.8	-0.2	-1.2	-1.0	0.7	-0.4	-2.0	-1.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.5	-1.6	-0.4	-0.7	0.2	1.0	-1.3	-0.4	-0.7	-1.3	0.6	-0.5	-1.2	-1.0	-0.6	-0.7	-0.5	0.5	-0.4	-0.4
Commuting to job workplace: Walk	0.6	0.6	1.4	-0.1	-0.2	0.3	1.1	0.4	0.1	-0.3	-0.8	-0.8	1.2	-0.3	-0.8	-1.1	-1.2	0.2	-1.1	-1.1	-0.7	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.1	-0.7	-1.5	-1.7	0.1	-0.3	-1.6	-1.3	0.6	-0.6	0.7	-1.4	-1.2	0.2	0.4	-1.3	-1.0	0.7	0.5	-1.0
Wears glasses or contact lenses	0.6	0.7	1.7	-0.9	-1.0	-1.0	0.3	-0.1	-1.0	-1.2	-0.3	-0.6	0.6	-0.9	-1.3	-0.5	-0.4	-0.9	-1.3	-0.5	-0.5	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.1	0.5	1.1	0.8	1.2	1.4	1.0	-0.3	-0.2	-0.1	1.3	0.4	0.6	0.1	-0.1	1.8	-0.0	0.5	-0.1	1.1
Medication: Paracetamol	0.6	1.0	2.5	-1.0	-1.6	-1.5	-0.2	-1.0	-1.6	-1.6	-0.4	-0.2	0.2	-1.3	-1.1	0.2	-0.0	-1.1	-1.1	-0.0	-0.0	-0.9
Basal cell carcinoma (self-reported)	0.6	0.7	3.3	0.8	-1.0	-0.6	1.0	-0.1	-0.7	-0.8	-0.2	-0.8	1.8	-1.1	-0.9	-0.5	-0.4	-0.0	-1.3	-0.1	-0.2	-0.9
Ever had hysterectomy (womb removed)	0.5	0.5	1.7	-0.1	-0.8	-0.9	-1.0	-0.6	-0.7	-1.3	0.6	-0.1	-0.5	-1.3	-0.5	0.3	0.5	-1.2	-0.1	0.4	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.3	-0.2	0.0	0.1	1.5	0.0	0.0	0.4	-1.4	0.1	1.2	0.2	-0.6	-1.2	-1.4	0.6	-0.6	-0.4	-0.5	-0.1
Medication: Co-codamol	0.5	0.6	1.9	-0.9	-0.5	-0.4	0.6	0.6	-1.0	0.1	-0.9	-1.1	0.7	0.0	-1.4	-0.9	-0.8	-0.7	-1.0	-0.2	-0.5	-1.0
Hand grip strength (right)	0.5	1.4	4.2	0.4	-1.2	-1.1	-0.7	-1.9	-0.1	-1.0	0.6	2.0	-1.2	-1.1	0.7	1.1	1.2	-0.9	0.5	1.7	2.0	1.1
Fed-up feelings	0.5	1.0	2.1	-1.1	-1.5	-1.4	-0.2	-0.7	-1.4	-1.4	0.0	-0.5	0.2	-1.2	-1.1	-0.1	-0.1	-1.2	-1.2	-0.7	-0.5	-1.4
Qualifications: CSEs or equivalent	0.5	0.7	2.3	1.5	-0.3	-0.2	-0.8	-0.4	-0.1	-0.2	0.9	0.4	-1.0	-0.0	0.9	1.0	0.6	-1.1	1.4	0.9	1.0	0.1
Medication: Levothyroxine sodium	0.5	0.8	2.3	-1.4	-0.6	-0.7	0.5	0.8	-0.7	-1.1	-0.3	-1.5	0.8	-1.1	-1.2	-0.6	-0.4	-0.3	-1.3	-0.9	-1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	0.9	1.1	1.0	-0.6	0.2	1.0	1.0	0.9	0.5	-0.5	0.9	0.9	0.2	0.3	0.7	1.1	0.6	0.6	0.8
Weight	0.5	2.7	9.1	-0.1	-2.0	-1.7	1.2	-0.6	-2.1	-1.5	-0.9	-1.6	1.6	-1.8	-1.9	-0.6	-1.1	-2.3	-1.8	-1.3	-1.2	-3.0
Time employed in main current job	0.5	0.6	1.9	-0.6	0.3	0.5	0.1	0.6	-0.2	1.2	-0.8	-1.0	-0.1	0.9	-0.2	-1.0	-1.1	-0.2	-0.2	-1.4	-1.2	-1.0
Prospective memory result	0.5	0.7	3.3	-0.0	1.2	1.0	0.4	1.8	0.8	1.1	-0.4	-0.3	-0.0	1.1	0.5	-0.3	-0.3	1.4	0.2	0.0	-0.1	0.9
Standing height	0.5	4.8	15.1	3.0	3.5	3.9	0.3	2.4	2.9	3.3	-0.2	-0.4	-0.5	3.2	2.3	-0.6	-0.7	2.0	2.5	-0.6	-1.0	1.2
Loud music exposure frequency	0.5	0.5	1.8	0.4	1.2	1.0	0.1	0.7	0.9	1.1	-0.4	0.7	-0.3	1.3	0.6	-0.4	-0.5	0.5	1.0	0.1	-0.0	0.6
Wheeze or whistling in the chest in last year	0.5	1.0	3.9	0.1	-0.4	-0.1	0.8	0.8	-1.1	0.5	0.1	-1.9	1.5	0.3	-0.4	-0.2	-0.4	-0.6	-1.2	-1.4	-1.2	-2.0
Comparative height size at age 10	0.5	3.0	10.8	0.4	2.1	2.1	0.9	3.3	0.8	2.0	-1.5	-2.2	0.6	1.8	0.1	-2.1	-2.0	1.0	0.5	-1.9	-2.7	-0.8
Illnesses of father: Heart disease	0.5	0.7	1.7	-0.4	-1.0	-1.2	0.5	-1.0	-1.0	-1.3	-0.9	-0.2	0.6	-1.1	-1.0	-0.6	-0.7	-1.0	-0.6	-0.0	0.0	-0.8
Illnesses of siblings: Diabetes	0.5	0.6	4.9	-0.5	-0.2	-0.2	-1.9	-0.5	0.0	-0.2	0.0	0.3	-2.2	-0.2	0.2	0.3	0.6	-0.7	0.5	-0.9	-0.3	-0.2
Medication for cholesterol	0.5	0.8	2.8	-0.4	-1.7	-1.6	-0.2	-1.4	-1.5	-0.8	0.1	-0.3	0.0	-1.1	-0.5	0.2	0.2	-1.3	-1.0	-0.0	0.6	-1.0
Average weekly champagne plus white wine intake	0.5	0.6	1.7	0.6	1.1	0.9	-0.6	0.1	0.8	1.3	0.7	0.5	-0.6	1.3	1.1	0.6	0.5	0.6	1.0	0.6	0.4	0.7
Illnesses of father: High blood pressure	0.5	0.6	2.3	-0.6	-0.8	-0.9	-1.5	-0.9	-0.8	-0.9	0.4	0.2	-1.2	-0.9	-0.4	0.4	0.2	-1.5	0.4	-0.1	-0.0	-0.7
Irritability	0.5	0.8	3.2	1.2	-0.8	-0.9	-0.8	-0.7	-0.8	-0.5	1.8	0.4	0.0	-0.5	0.2	1.7	1.2	-0.7	0.2	1.1	1.1	-0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.7	0.7	0.4	0.6	-0.9	0.6	0.6	0.1	1.7	0.4	-0.3	0.4	0.5	0.7	1.1	0.4	0.5	1.3	0.9	0.9
Cholesterol lowering medication	0.5	0.8	2.2	-0.4	0.9	1.0	1.1	0.8	0.8	0.7	-1.4	-0.3	0.4	1.0	-0.2	-1.5	-1.3	0.7	0.0	-1.1	-1.2	-0.1
Supplements: Calcium	0.5	0.5	1.4	0.3	-0.9	-0.7	-0.7	0.2	-0.8	-1.1	1.1	-0.8	-0.2	-1.2	-0.4	1.0	1.0	-0.7	-0.5	0.3	0.2	-0.5
Heart disease (siblings)	0.5	0.6	1.6	0.7	0.7	0.8	-0.7	-0.6	1.0	0.7	-0.4	1.3	-1.2	1.0	1.0	-0.1	-0.0	0.6	0.9	0.1	0.5	1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	0.3	-1.2	-1.0	-0.6	-0.9	-0.8	-1.3	1.5	-0.3	0.1	-1.1	-0.3	1.3	1.2	-0.9	-0.8	0.1	0.3	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	0.0	1.3	1.0	-0.3	0.7	0.4	1.2	-0.2	-0.1	-0.7	1.3	0.5	-0.6	-0.4	0.4	1.1	0.2	-0.5	0.6
Major Depression (MDD)	0.4	0.5	2.2	1.0	0.4	0.7	0.7	0.1	1.0	0.3	0.5	0.5	0.7	0.5	0.9	0.2	0.4	1.5	0.1	0.4	0.9	1.1
Reaction Time	0.4	0.8	2.7	1.0	1.3	1.1	0.8	0.8	0.9	1.2	0.3	0.3	0.6	1.3	0.8	0.1	0.1	1.6	0.6	0.4	0.4	1.1
Heel T-Score	0.4	3.1	7.8	1.9	1.5	1.7	-1.8	-0.5	2.2	1.8	1.5	2.1	-2.6	1.9	2.8	1.3	1.3	0.7	2.5	0.3	0.7	1.5
Respiratory disease	0.4	1.0	3.8	0.4	0.1	0.4	0.7	0.6	-0.5	1.0	-0.9	-1.3	1.1	0.7	-0.4	-1.0	-1.4	-0.6	-0.5	-1.5	-1.4	-1.9
Average weekly spirits intake	0.4	0.5	1.2	-0.8	0.2	0.1	0.7	0.4	-0.4	0.4	-1.1	-0.8	0.5	0.2	-0.7	-0.9	-0.9	0.5	-0.6	-1.1	-0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.8	-1.1	-1.7	-1.5	-0.9	-1.7	-1.0	-0.6	0.1	0.7	-1.2	-0.9	-0.8	0.2	0.4	-1.5	-0.8	-0.7	0.0	-0.9
Had menopause	0.4	0.4	1.1	-0.7	-1.0	-0.9	-0.4	-0.7	-0.8	-0.8	0.2	-0.4	-0.2	-0.8	-0.6	0.2	0.4	-0.6	-0.9	-0.8	-0.5	-0.8
Mouth/teeth dental problems	0.4	0.7	1.7	0.5	1.0	1.2	0.7	0.1	1.3	0.7	-1.1	0.6	0.3	0.9	0.5	-1.0	-1.1	0.9	0.4	-1.1	-0.5	0.3
Fluid intelligence score	0.4	0.8	2.4	0.4	0.4	0.6	-0.4	-1.3	1.1	1.3	-0.0	1.5	-1.4	1.1	1.5	0.4	0.5	0.0	1.1	0.2	0.8	0.7
Father’s age at death	0.4	0.5	2.7	0.2	0.3	0.4	-1.6	0.1	0.4	0.6	0.6	0.4	-1.6	0.1	0.6	0.6	0.6	-0.9	1.2	0.2	0.1	-0.1
Falls in the last year	0.4	0.5	1.1	-0.1	-0.4	-0.6	0.6	0.2	-0.7	-0.9	-0.6	-0.9	0.9	-0.9	-0.6	-0.5	-0.7	-0.1	-0.7	-1.1	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	2.7	0.2	-0.6	-0.6	-1.2	-0.2	-0.5	-0.3	1.5	0.3	-0.8	-0.4	0.1	1.2	1.7	-0.3	0.0	1.4	1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	-0.0	-0.8	-0.8	1.1	-0.3	-1.0	-0.5	-0.4	-0.5	1.3	-0.7	-0.8	-0.5	-0.6	-0.5	-0.8	0.2	0.2	-0.8
Exposure to tobacco smoke at home	0.4	0.5	2.3	0.5	0.8	0.8	0.1	-0.0	0.6	1.5	-0.7	0.1	-0.3	1.3	0.7	-0.4	-0.6	0.5	0.7	-0.3	-0.1	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	-1.1	-0.4	-0.4	0.4	-0.3	-0.0	-0.8	-1.2	0.2	-0.1	-0.8	-0.5	-0.7	-0.7	-0.1	-0.8	-1.0	-0.7	-0.4
Number of full brothers	0.4	0.6	1.5	-1.2	-0.6	-0.7	0.9	-0.0	-0.8	-0.7	-1.2	-0.8	0.6	-0.4	-0.7	-0.7	-0.7	0.2	-1.1	-0.7	-0.4	-0.1
Alcohol intake frequency.	0.4	0.9	3.8	1.6	0.2	0.2	-0.4	-1.2	1.1	0.0	0.6	2.0	-0.8	0.3	1.1	1.0	0.9	0.7	0.8	0.6	1.2	1.1
Smoking status: Previous	0.4	0.6	2.0	-0.0	0.6	0.6	1.4	0.4	0.7	0.2	-1.2	0.0	0.8	0.3	-0.1	-1.2	-1.1	1.3	-0.4	-0.5	-0.4	0.7
Loneliness, isolation	0.4	0.5	3.1	-0.0	-0.3	-0.2	-1.6	-1.3	0.1	0.0	0.7	0.6	-1.8	-0.1	0.7	0.4	0.6	-0.4	0.5	-0.6	0.0	-0.1
Osteoporosis (self-reported)	0.4	0.4	1.4	0.2	-0.4	-0.6	-1.0	0.3	-0.7	-0.2	1.0	-0.3	-0.4	-0.5	0.2	1.2	0.9	-1.1	0.6	0.7	0.7	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.5	0.7	1.0	0.6	1.1	1.0	0.9	0.2	-0.4	0.7	0.9	0.3	0.1	0.2	1.3	-0.5	-0.6	-0.5	0.1
Smoking status: Current	0.4	0.6	1.6	-0.8	0.4	0.5	1.2	1.1	0.1	0.3	-1.3	-1.0	1.0	0.3	-0.7	-1.0	-1.2	0.2	-0.3	-0.5	-0.8	-0.3
Eye problems/disorders: Glaucoma	0.4	0.4	1.6	-0.1	-0.4	-0.4	0.0	-0.5	-0.6	-0.1	-0.7	-0.9	0.4	-0.4	-0.5	-0.5	-0.5	-0.2	-1.1	-1.3	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.7	-1.1	-0.6	-0.5	-1.0	0.7	-1.1	-0.2	0.2	-1.3	-0.4	-0.4	-0.9	-0.0	0.1	-1.0	-0.8	-0.3	-0.6	-1.1
Medication: Bendroflumethiazide	0.4	0.6	1.7	0.5	-0.1	-0.3	-1.1	-0.8	0.3	-0.5	0.7	1.2	-1.3	-0.5	0.4	1.0	1.0	-0.1	0.8	0.7	0.8	0.9
Ever smoked	0.4	0.6	2.1	-0.4	0.4	0.6	1.4	1.4	0.2	0.3	-0.7	-1.1	1.4	0.4	-0.4	-1.1	-1.0	0.9	-0.7	-0.2	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.7	0.3	0.4	0.5	1.0	1.1	-0.1	0.7	-0.3	-1.0	1.7	0.6	-0.4	-0.8	-0.8	0.1	-0.4	0.0	-0.7	-0.7
Alcohol drinker status: Previous	0.4	0.4	0.9	0.9	0.8	0.8	0.6	0.9	0.5	0.7	0.2	-0.5	0.7	0.9	0.1	-0.6	-0.5	0.9	-0.2	-0.7	-0.7	-0.3
Depression (Nagel 2018)	0.3	0.5	1.4	0.6	-0.9	-0.8	0.5	-1.0	-0.4	-1.2	0.8	-0.2	0.8	-0.9	-0.2	0.4	0.3	-0.0	-1.1	-0.6	-0.0	-0.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.1	0.2	-0.6	-0.4	-0.9	-2.0	0.5	0.1	0.5	1.8	-1.5	-0.2	0.9	1.0	1.0	-1.0	0.9	0.6	1.3	0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.7	0.6	-1.2	-1.0	-0.3	-1.1	-0.7	-1.3	1.0	-0.2	0.4	-1.1	-0.5	0.9	0.8	-0.7	-1.2	-0.2	0.2	-1.1
Fasting Glucose	0.3	0.4	1.2	-0.8	-0.1	-0.3	0.8	-0.1	-0.4	0.3	-0.6	-0.2	0.6	0.5	-0.9	-1.0	-0.8	-0.1	-0.8	-1.1	-0.8	-0.6
HbA1C	0.3	0.3	1.5	-0.5	-0.1	0.1	1.2	0.5	-0.2	-0.5	-0.2	-0.9	0.9	-0.0	-0.6	-0.2	-0.1	0.8	-1.0	-0.3	-0.3	0.3
Chronotype (morning person)	0.3	0.7	2.9	-1.7	0.1	-0.2	0.5	1.1	-0.7	0.1	-1.3	-0.9	0.2	0.4	-1.1	-1.4	-1.3	-0.7	-0.5	-0.3	-0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.3	-0.9	-0.8	-0.3	-1.3	-0.5	-0.6	0.4	0.4	-0.3	-0.7	-0.3	0.5	0.6	-0.7	-0.5	-0.6	-0.1	-0.7
Medication for hormone replacement therapy	0.3	0.3	1.1	-0.5	0.8	0.6	-0.4	0.9	0.1	1.0	-0.3	-0.0	-0.5	0.9	-0.1	-0.8	-0.3	0.5	0.2	-0.5	-0.7	0.3
Diabetes (father)	0.3	0.3	2.2	0.3	-0.8	-0.7	0.2	-1.5	-0.2	-0.7	0.3	1.0	-0.0	-0.6	0.1	0.3	0.4	-0.1	-0.3	0.3	0.7	0.3
Pack years adult smoking proportion	0.3	0.5	1.1	-0.8	-0.9	-0.9	-0.8	-1.0	-0.4	-1.1	0.2	0.2	-1.0	-0.8	-0.1	0.4	0.6	-0.8	-0.5	-0.6	0.1	-0.4
Townsend deprivation index at recruitment	0.3	0.5	2.4	-1.0	0.7	0.5	0.1	1.6	0.1	-0.1	-0.6	-1.0	-0.0	0.1	-0.7	-0.7	-0.8	0.3	0.2	-0.5	-1.0	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.4	1.2	-0.7	-0.7	0.5	-0.6	-0.4	-0.8	1.0	-0.2	1.1	-0.6	0.2	0.9	0.6	-0.4	-0.4	0.4	0.7	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.1	0.3	0.4	1.2	0.0	0.3	0.1	-1.0	-0.1	1.0	0.2	-0.4	-1.1	-1.0	0.9	-0.4	-0.3	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.4	-0.4	-1.3	-1.2	-0.7	-1.8	-0.6	-0.6	0.2	1.1	-1.2	-0.6	-0.1	0.5	0.5	-1.0	-0.4	-0.4	0.4	-0.2
Allergy	0.3	0.6	2.1	-0.7	-0.8	-0.8	0.1	-1.1	-0.3	-1.4	-0.1	0.6	-0.4	-1.3	-0.6	0.6	0.6	0.0	-0.4	0.9	1.0	1.0
Medication: Ramipril	0.3	0.4	1.1	0.4	-0.7	-0.7	-0.9	-0.3	-0.5	-1.0	1.1	0.0	-0.4	-0.9	-0.4	0.8	0.8	-0.5	0.0	0.8	0.5	-0.0
Neuroticism score	0.3	0.5	1.6	1.0	-0.9	-0.8	-0.3	-1.3	-0.6	-0.8	1.1	0.2	0.4	-0.7	-0.2	0.8	0.6	-0.6	-0.5	0.3	0.6	-0.7
Worrier / anxious feelings	0.3	0.6	2.1	1.1	-1.2	-0.9	0.2	-1.4	-0.8	-0.7	0.6	-0.1	0.9	-0.5	-0.4	0.4	0.3	-0.7	-0.9	0.1	0.6	-1.0
Happiness	0.3	0.3	1.2	0.3	0.4	0.7	0.3	-0.3	0.9	0.9	-0.3	0.3	0.0	0.7	0.3	-0.5	-0.5	0.9	-0.1	-1.1	-0.4	0.1
Medication: Amlodipine	0.3	0.4	1.9	-0.8	-0.8	-0.5	-0.6	-0.0	-0.1	-1.4	0.3	-0.1	-0.8	-1.1	-0.5	0.5	0.8	-0.8	-0.3	-0.4	-0.3	-0.5
Birth weight	0.3	0.6	4.8	2.2	0.8	1.1	0.6	0.7	0.5	1.1	0.2	-0.3	0.9	1.1	0.5	-0.2	-0.4	0.8	0.1	-0.1	-0.1	-0.1
Worry too long after embarrassment	0.3	0.6	4.4	0.4	-1.3	-0.9	-0.1	-2.1	-0.6	-0.5	-0.1	0.6	-0.0	-0.4	-0.4	-0.2	-0.1	-1.0	-0.6	-0.1	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.1	-0.7	-0.6	0.3	-0.3	-0.8	-1.1	-0.1	-0.6	0.8	-0.9	-1.0	-0.1	-0.2	-0.4	-1.0	-0.4	-0.4	-0.9
Shortness of breath walking on level ground	0.3	0.3	1.1	-0.4	0.6	0.5	0.5	1.0	0.3	0.4	-0.0	-0.9	0.4	0.7	0.1	-0.3	-0.3	0.6	-0.6	-1.0	-0.9	-0.3
Qualifications: College or University degree	0.3	0.8	3.0	-0.4	0.8	0.6	-1.2	-0.2	1.0	0.6	0.4	1.3	-1.7	0.7	1.2	0.6	0.7	0.7	1.1	0.6	0.8	1.4
Eye problems/disorders: None of the above	0.3	0.4	1.2	-0.6	-0.5	-0.5	-0.2	0.7	-0.8	-0.5	0.8	-1.1	0.2	-0.5	-0.5	0.6	0.5	-0.3	-0.7	-0.5	-0.4	-0.8
Heart disease (mother)	0.3	0.3	1.6	-1.3	0.3	0.2	0.1	1.3	-0.0	0.3	-0.6	-0.8	0.1	0.4	-0.5	-0.5	-0.5	0.3	-0.6	-0.5	-0.7	-0.3
Chest pain or discomfort	0.3	0.4	1.7	0.0	-0.3	-0.3	-1.2	-0.4	0.0	-0.5	0.6	0.1	-1.3	-0.3	0.8	1.0	0.9	-0.9	0.4	-0.5	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	1.3	0.9	0.9	0.2	0.5	1.0	0.8	0.1	0.6	-0.1	0.8	0.7	0.0	0.2	0.8	1.0	0.7	0.5	1.0
Mineral and other dietary supplements	0.3	0.5	1.6	0.8	0.6	0.4	0.7	0.1	0.8	-0.2	0.4	0.8	0.4	0.1	0.7	0.4	0.4	1.1	0.6	0.9	0.7	1.3
Breast cancer (self-reported)	0.3	0.4	1.8	-1.4	-0.4	-0.6	0.4	-0.3	-0.3	-1.0	-0.9	-0.0	0.3	-0.8	-0.6	-0.4	-0.1	0.4	-0.7	0.4	0.3	0.6
High cholesterol (Self-reported)	0.3	0.6	1.7	1.3	0.8	0.7	1.0	0.3	0.8	1.1	0.1	0.7	0.9	1.2	0.7	-0.2	-0.2	0.8	0.6	0.9	0.5	0.8
Medication: Atorvastatin	0.3	0.4	2.2	1.5	0.2	-0.1	0.7	0.7	-0.3	0.2	0.7	-0.7	1.3	0.4	0.0	0.1	0.1	-0.1	0.0	1.1	0.5	-0.3
Worry (Nagel 2018)	0.2	0.4	0.9	0.9	-0.6	-0.6	-0.4	-1.0	-0.1	-1.0	0.7	0.6	0.1	-0.8	-0.2	0.8	0.8	-0.3	-0.4	0.6	0.8	-0.1
Crohns Disease (2012)	0.2	0.3	1.3	-0.7	-0.6	-0.6	0.4	-0.6	-0.3	-0.2	-0.5	0.6	-0.2	0.1	0.5	-0.1	0.1	-0.4	0.1	0.4	1.2	0.5
Neuroticism (2016)	0.2	0.3	1.6	0.6	-0.2	0.2	0.3	0.1	0.0	0.2	0.1	-0.6	0.7	0.3	0.2	-0.4	-0.2	-0.0	-0.9	-1.3	-0.7	-1.2
Blood Red Count	0.2	2.3	8.5	1.1	0.1	-0.2	-1.1	-2.4	1.1	-0.1	0.7	2.9	-2.1	-0.0	1.6	1.5	1.4	0.3	1.7	1.5	2.1	2.1
Allergy or Eczema	0.2	0.6	1.8	-0.1	1.0	1.0	-0.2	1.1	0.6	1.3	-0.3	-0.3	-0.5	1.2	0.7	-0.3	-0.4	0.4	0.5	-1.2	-1.1	-0.4
Sensitivity / hurt feelings	0.2	0.3	1.1	0.6	0.2	0.6	1.1	-0.1	0.8	-0.0	-0.4	-0.3	0.7	0.2	0.2	-0.9	-0.8	0.8	-0.2	-0.7	-0.3	-0.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	1.1	-0.0	0.2	0.6	-1.0	0.7	-0.5	0.3	0.5	0.6	-0.0	0.6	0.3	0.2	0.5	-0.2	-0.6	0.1	-0.1
Relative age of first facial hair	0.2	0.3	1.0	0.8	0.1	0.2	-0.4	-0.3	0.5	0.1	0.8	0.5	-0.5	-0.1	0.6	0.7	0.6	-0.2	1.0	0.8	0.8	0.4
Systolic blood pressure, automated reading	0.2	0.7	2.2	0.5	0.6	0.7	0.0	1.2	-0.6	1.5	0.1	-1.3	0.8	1.3	0.0	-0.6	-0.8	-0.4	0.0	-0.5	-1.1	-1.3
Impedance of leg (right)	0.2	0.9	3.2	-0.7	1.5	1.3	-0.8	1.4	1.3	0.7	0.0	0.1	-1.0	1.2	0.5	-0.3	0.1	1.8	0.3	-0.8	-0.9	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	0.5	0.6	0.5	0.4	-0.3	0.9	0.1	-0.0	1.0	-0.2	0.4	0.4	0.0	0.0	0.5	0.8	0.3	0.5	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.4	-0.0	0.8	0.6	-0.8	1.1	0.3	1.2	0.3	-0.3	-0.7	1.1	0.6	-0.0	-0.0	-0.0	0.6	-0.7	-0.7	-0.4
Past tobacco smoking	0.2	0.3	1.5	-0.0	-0.2	-0.4	-1.2	-0.4	-0.5	0.0	0.7	0.1	-0.8	-0.2	0.1	0.9	0.8	-0.8	0.4	0.2	0.1	-0.5
Pain all over the body in last month	0.2	0.2	0.7	0.2	-0.1	0.2	-0.6	0.4	0.0	0.3	0.8	-0.5	-0.3	0.4	0.2	0.3	0.6	-0.2	-0.2	-0.7	-0.6	-0.7
Impedance of arm (right)	0.2	1.2	2.8	0.7	1.7	1.5	-1.3	1.6	1.1	1.4	0.9	-0.2	-0.9	1.5	1.0	0.1	0.6	1.2	1.1	0.2	-0.3	0.9
Trunk fat-free mass	0.2	0.9	2.3	1.5	1.1	1.5	1.1	0.4	1.1	1.3	-1.0	-0.2	0.3	1.0	0.8	-0.6	-1.1	0.1	0.9	-1.3	-0.9	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.4	-0.7	-0.7	0.3	-0.3	-0.6	-0.7	0.5	-0.5	0.8	-0.7	-0.1	0.2	0.0	-0.7	-0.7	-0.2	-0.0	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.6	0.3	0.1	-0.8	0.6	0.2	0.2	0.8	0.1	-0.5	0.2	0.3	0.6	0.7	-0.1	0.6	1.0	0.4	0.4
Lung cancer (father)	0.2	0.2	0.7	-0.0	0.2	-0.0	0.2	0.7	0.2	0.1	0.5	-0.3	0.4	0.0	-0.2	0.2	0.1	0.4	-0.8	-0.9	-0.7	-0.5
Impedance of arm (left)	0.2	1.1	2.6	0.9	1.6	1.4	-1.0	1.4	1.2	1.2	0.8	-0.0	-0.7	1.4	1.1	0.1	0.6	1.3	1.2	0.6	0.0	1.1
Trunk predicted mass	0.2	0.9	2.3	1.5	1.0	1.5	1.1	0.3	1.1	1.2	-0.9	-0.1	0.2	0.9	0.9	-0.6	-1.1	0.0	1.0	-1.2	-0.9	-0.4
Tense / ‘highly strung’	0.2	0.3	1.4	0.6	-0.5	-0.4	-0.4	-0.7	-0.2	-0.7	0.3	0.1	-0.4	-0.6	-0.1	0.1	0.0	-1.0	0.0	-0.9	-0.5	-1.2
Blood clot in the leg (DVT)	0.2	0.3	2.0	0.3	0.0	0.2	0.6	0.8	-0.3	0.3	0.1	-0.8	1.4	0.2	-0.4	-0.5	-0.5	-0.2	-0.5	0.1	-0.5	-0.9
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.4	0.2	-0.2	-0.8	0.1	-0.1	-0.2	0.7	0.0	-0.7	-0.1	0.5	0.8	0.8	-0.0	0.7	0.4	0.4	0.4
Age at first live birth	0.2	0.3	1.4	-1.2	-0.5	-0.6	0.4	-0.2	-0.6	-0.6	-0.7	-0.1	0.1	-0.5	-0.6	-0.4	-0.6	-0.8	-0.3	-0.2	-0.1	-0.6
Mean time to correctly identify matches	0.2	0.3	0.7	0.1	-0.7	-0.8	0.0	-0.6	-0.5	-0.6	0.7	0.3	0.2	-0.5	-0.1	0.7	0.8	-0.1	-0.5	0.6	0.8	0.1
Age at last live birth	0.2	0.3	0.8	0.2	0.8	0.7	-0.3	0.3	0.7	0.7	0.1	0.4	-0.8	0.7	0.7	0.2	0.1	0.3	0.9	0.0	0.1	0.6
Friendships satisfaction	0.2	0.3	1.6	-0.7	0.3	0.3	-0.8	0.2	0.4	0.6	0.2	-0.0	-1.1	0.5	0.2	0.1	0.3	-0.0	-0.1	-1.3	-0.7	-0.3
Osteoarthritis (self-reported)	0.2	0.2	1.0	0.3	-0.4	-0.3	-0.1	0.2	-0.8	0.2	0.3	-0.5	0.3	0.1	-0.6	-0.1	-0.2	-1.0	-0.4	0.3	0.1	-0.9
Hearing aid user	0.2	0.3	1.6	-0.4	0.5	0.5	0.1	1.3	0.0	1.0	-0.3	-0.8	0.3	0.7	-0.0	-0.2	-0.4	0.2	-0.1	-0.1	-0.5	-0.2
Average weekly beer plus cider intake	0.2	0.2	0.6	0.3	-0.7	-0.6	-0.2	-0.7	-0.6	-0.5	0.6	-0.0	-0.2	-0.8	-0.0	0.4	0.3	-0.8	0.0	0.1	0.4	-0.3
Age started oral contraceptive pill	0.2	0.2	0.9	-0.3	-0.7	-0.7	0.1	-0.9	-0.4	-0.5	0.3	0.1	0.3	-0.6	-0.1	0.3	0.2	-0.3	-0.8	-0.5	-0.1	-0.7
Diastolic blood pressure, automated reading	0.2	0.6	2.2	1.1	0.9	0.8	1.1	1.4	-0.2	1.0	0.2	-0.9	1.5	1.0	-0.0	-0.3	-0.6	0.3	0.2	0.5	-0.4	-0.3
Impedance of whole body	0.2	0.8	1.8	0.3	1.3	1.0	-1.3	1.1	1.0	0.7	0.9	0.2	-1.0	1.1	0.8	0.3	0.8	1.3	0.8	0.6	0.1	1.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.6	-0.3	-0.0	-0.3	-0.1	-0.8	-0.0	-0.1	-0.1	0.5	-0.3	-0.1	-0.2	0.1	0.3	-0.0	-0.5	-0.8	-0.6	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.3	0.2	0.0	0.1	-0.3	-1.0	0.6	0.5	-0.0	1.1	-0.6	0.3	0.7	0.4	0.4	-0.1	0.5	0.4	0.6	0.3
Mean Putamen Volume	0.1	0.2	0.7	-0.5	-0.4	-0.3	-0.4	-0.3	-0.1	-0.9	0.4	0.1	-0.4	-0.8	-0.1	0.5	0.5	-0.2	-0.1	-0.1	0.1	0.1
Rheumatoid Arthritis	0.1	0.1	0.4	-0.5	0.0	0.1	0.4	0.3	-0.0	0.0	-0.3	-0.5	0.4	-0.2	-0.2	-0.6	-0.4	0.6	-0.6	-0.5	-0.5	-0.0
Blood White Count	0.1	0.6	2.2	-0.6	0.7	0.4	-0.5	1.1	0.4	0.3	0.5	0.1	-0.9	0.5	0.9	0.1	0.6	0.3	1.4	1.2	0.7	1.5
Height	0.1	1.9	5.2	1.2	1.6	2.0	0.1	1.9	0.5	1.6	-1.1	-1.9	-0.1	1.6	0.2	-1.2	-1.3	0.7	0.2	-2.0	-2.3	-0.8
Systolic Blood Pressure	0.1	0.5	3.4	-0.7	0.9	0.7	-0.9	1.8	0.2	0.5	0.1	-0.8	-0.7	0.9	-0.0	-0.4	-0.1	0.2	0.4	0.0	-0.8	0.1
Cardiovascular Disease	0.1	0.4	1.5	0.2	0.8	0.6	-0.1	0.5	1.1	-0.5	0.3	0.9	-0.2	0.1	0.1	0.5	0.7	1.0	0.7	0.5	0.3	1.2
Hypothyroidism (self reported)	0.1	0.3	1.1	-1.0	-0.2	-0.1	0.2	0.4	-0.0	-0.1	-0.6	-0.5	-0.1	-0.0	-0.4	-0.7	-0.5	-0.2	-0.7	-1.0	-0.9	-0.6
Neuroticism	0.1	0.1	0.4	0.7	-0.2	0.1	-0.2	-0.6	0.4	-0.5	0.6	0.3	-0.0	-0.3	0.2	0.6	0.4	0.1	-0.1	-0.2	0.2	-0.2
Tanning	0.1	1.3	3.3	-1.5	-1.3	-1.4	0.8	-0.6	-1.5	-1.4	-1.1	-0.6	0.9	-1.3	-1.8	-0.9	-1.0	-1.0	-1.3	-0.4	-0.5	-0.9
Leg fat-free mass (left)	0.1	0.6	2.0	1.1	-0.7	-0.3	1.1	-0.5	-0.7	-0.3	-0.6	-0.6	0.9	-0.6	-0.3	-0.3	-0.8	-1.4	0.0	-0.3	-0.2	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.9	0.9	-0.1	-0.1	0.2	0.1	0.3	-0.4	0.7	-0.1	0.6	-0.3	0.5	0.3	0.3	0.4	-0.3	-0.3	-0.1	-0.2
Age when periods started (menarche)	0.1	0.2	0.7	-0.3	0.3	0.3	-0.3	0.0	0.5	0.5	-0.1	0.2	-0.6	0.3	0.3	-0.4	-0.2	0.6	0.3	0.1	0.4	0.9
High blood pressure	0.1	0.2	0.7	0.0	0.7	0.6	-0.6	0.8	0.4	-0.2	0.4	-0.2	-0.4	0.2	-0.0	0.4	0.5	0.4	0.4	0.2	-0.4	0.4
Impedance of leg (left)	0.1	0.6	2.4	-0.8	1.1	0.9	-0.9	1.1	1.0	0.4	0.3	0.1	-0.9	0.9	0.4	0.1	0.5	1.5	0.1	-0.1	-0.3	1.3
Leg predicted mass (left)	0.1	0.5	1.9	1.3	-0.6	-0.3	1.0	-0.5	-0.7	-0.3	-0.4	-0.5	0.8	-0.5	-0.2	-0.2	-0.7	-1.4	0.2	-0.1	-0.1	-1.3
Alcohol usually taken with meals	0.1	0.2	0.9	-0.2	0.3	0.3	-0.2	0.8	-0.0	0.3	0.6	-0.9	0.5	0.5	0.2	0.5	0.5	0.7	-0.5	-0.3	-0.5	0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	1.2	0.4	0.1	-0.1	0.5	-0.2	-0.2	0.3	0.2	0.2	0.8	0.2	0.1	0.1	0.0	0.2	-0.0	1.1	0.7	0.4
Medication: Simvastatin	0.1	0.1	0.7	-0.8	0.0	-0.2	-0.3	0.6	-0.2	-0.3	-0.5	-0.0	-0.5	0.0	-0.5	-0.7	-0.3	-0.3	0.1	0.2	-0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.7	-0.2	-0.2	-0.0	0.5	-0.0	-0.5	-0.1	-0.6	-0.1	-0.5	-0.4	-0.2	-0.0	-0.1	-0.6	-0.6	-0.6	-0.4
Arm fat-free mass (right)	0.1	0.5	1.4	0.6	-0.9	-0.6	1.1	-1.0	-0.6	-0.8	-0.7	-0.2	0.7	-0.9	-0.4	-0.2	-0.7	-1.2	-0.4	-0.5	-0.2	-1.1
Emphysema/chronic bronchitis	0.1	0.2	0.5	0.3	0.7	0.7	0.2	0.6	0.5	0.1	-0.1	-0.1	0.4	0.3	-0.2	-0.2	-0.1	0.7	0.4	0.4	-0.1	0.5
Arm predicted mass (right)	0.1	0.5	1.4	0.7	-0.7	-0.5	1.2	-0.8	-0.5	-0.6	-0.7	-0.3	0.9	-0.7	-0.3	-0.2	-0.7	-1.0	-0.4	-0.6	-0.3	-1.1
Suffer from ‘nerves’	0.1	0.1	0.5	0.7	-0.1	-0.2	-0.0	-0.5	-0.3	-0.2	0.5	-0.0	0.5	-0.1	-0.3	0.2	0.1	-0.3	-0.4	-0.2	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	1.0	1.0	0.3	0.2	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.1	-0.1	0.5	-0.1	-0.2	-0.0	0.7	-0.1	-0.2	-0.1
Hypertension (Self-reported)	0.1	0.2	0.6	-0.3	0.4	0.4	-0.8	0.8	0.2	-0.5	0.6	-0.5	-0.5	-0.1	-0.3	0.5	0.6	0.1	0.1	-0.0	-0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.9	-0.3	-0.0	0.2	0.2	0.2	-0.1	0.1	-0.6	-0.3	0.0	0.0	-0.6	-1.0	-0.8	0.0	-0.2	-0.5	-0.5	-0.2
Whole body fat-free mass	0.1	0.5	1.6	1.3	0.2	0.6	1.2	-0.1	0.2	0.5	-0.9	-0.3	0.6	0.2	0.3	-0.5	-1.0	-0.6	0.5	-0.8	-0.6	-0.9
Leg fat-free mass (right)	0.1	0.4	1.8	1.3	-0.5	-0.2	0.9	-0.6	-0.5	-0.2	-0.3	-0.3	0.7	-0.4	0.1	0.0	-0.5	-1.3	0.3	0.2	0.2	-1.0
Whole body water mass	0.1	0.4	1.7	1.3	0.1	0.5	1.1	-0.2	0.2	0.4	-0.7	-0.3	0.5	0.2	0.3	-0.4	-0.9	-0.7	0.4	-0.7	-0.5	-0.8
Leg predicted mass (right)	0.1	0.4	2.0	1.2	-0.6	-0.3	0.8	-0.7	-0.6	-0.3	-0.3	-0.3	0.6	-0.5	0.0	0.1	-0.4	-1.4	0.3	0.2	0.3	-1.0
Miserableness	0.1	0.3	1.1	0.3	-0.5	-0.5	-0.1	-1.1	-0.3	-0.2	0.8	0.6	0.1	0.0	0.0	0.5	0.6	-0.5	-0.1	0.6	0.8	-0.2
Mother’s age at death	0.1	0.1	0.4	-0.5	0.0	-0.0	-0.4	0.3	0.3	-0.6	0.1	-0.3	-0.2	-0.5	-0.0	0.2	0.5	0.3	-0.3	-0.4	-0.5	-0.1
Medication: Blood pressure	0.1	0.2	0.9	-0.0	0.8	0.9	-0.2	0.7	1.0	-0.2	-0.1	-0.0	-0.4	0.2	0.0	-0.0	-0.1	0.5	0.6	-0.2	-0.6	0.4
Basal metabolic rate	0.1	0.6	1.9	1.0	-0.3	0.1	1.2	-0.2	-0.3	0.1	-0.9	-0.7	0.8	-0.2	-0.2	-0.5	-1.1	-1.1	-0.1	-0.9	-0.7	-1.4
Arm fat-free mass (left)	0.1	0.3	1.2	0.9	-0.3	0.1	1.1	-0.6	-0.0	-0.1	-0.8	-0.1	0.5	-0.2	0.1	-0.3	-0.8	-0.7	-0.0	-0.8	-0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.4	0.3	-0.4	-0.3	0.2	-1.2	-0.1	0.6	-0.3	0.7	-0.1	0.2	0.3	-0.3	-0.3	-0.2	-0.0	-0.1	0.6	-0.1
Arm predicted mass (left)	0.1	0.6	1.8	0.6	-0.7	-0.3	1.1	-0.6	-0.5	-0.4	-0.9	-0.5	0.7	-0.6	-0.4	-0.5	-0.9	-1.1	-0.4	-1.0	-0.6	-1.4
Blood Platelet Count	0.0	0.5	1.5	0.9	1.1	0.9	-0.0	-0.1	0.9	0.9	-0.0	0.3	0.0	1.0	0.5	-0.5	-0.2	0.4	1.2	0.9	0.2	0.8
Hair Pigment	0.0	0.1	0.5	-0.7	0.1	0.2	-0.2	0.2	0.3	0.3	0.2	0.3	-0.5	0.7	0.1	-0.0	0.4	0.5	0.3	-0.2	-0.1	0.7

Hub : Genes

SYNM

Models

Trait associations