[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr15:83,167,559-86,489,699

Best TWAS P=2.63e-29 · Best GWAS P=1.55e-47 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADAMTSL3	0.10	0.04	lasso	4	0.04	8.7e-06	-13.5	-9.9	5.5e-23	-0.43	0.22	0.11	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC388152	0.14	0.14	enet	20	0.18	6.7e-22	5.3	-8.4	5.1e-17	-0.19	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBE2Q2P1	0.08	0.04	blup	382	0.05	2.3e-06	-8.0	6.0	1.8e-09	0.06	0.95	0.00	FALSE
4	GTEx	Adipose Subcutaneous	AC103965.1	0.24	0.14	lasso	6	0.15	2.6e-12	5.2	-7.0	2.2e-12	-0.20	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	RP11-182J1.14	0.11	0.11	lasso	9	0.12	8.1e-10	5.3	5.3	1.1e-07	0.22	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	CSPG4P11	0.19	0.17	lasso	5	0.20	7.9e-16	5.2	-6.8	1.3e-11	-0.19	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	BTBD1	0.20	0.01	enet	24	0.06	5.1e-04	3.5	-5.8	6.1e-09	-0.16	0.31	0.17	FALSE
8	GTEx	Adipose Visceral Omentum	GOLGA6L3	0.23	0.05	lasso	5	0.07	2.2e-04	-7.7	-6.5	7.9e-11	-0.13	0.00	1.00	FALSE
9	GTEx	Adrenal Gland	AC103965.1	0.09	0.00	enet	5	-0.01	7.7e-01	5.2	-5.2	1.6e-07	-0.20	0.09	0.08	FALSE
10	GTEx	Artery Aorta	ADAMTSL3	0.17	0.01	enet	13	0.08	4.6e-05	3.9	5.2	2.3e-07	-0.05	0.86	0.01	FALSE
11	GTEx	Artery Aorta	UBE2Q2P1	0.15	0.00	enet	21	0.05	8.4e-04	-3.0	6.9	4.5e-12	0.13	0.28	0.10	FALSE
12	GTEx	Artery Aorta	AC103965.1	0.10	0.12	lasso	3	0.10	3.9e-06	5.3	-5.2	1.6e-07	-0.18	0.95	0.02	FALSE
13	GTEx	Artery Aorta	CSPG4P11	0.11	0.10	lasso	4	0.08	3.1e-05	5.2	-5.3	1.2e-07	-0.18	0.93	0.01	FALSE
14	GTEx	Artery Coronary	AC103965.1	0.15	0.08	enet	21	0.14	2.6e-05	-4.8	-6.6	5.2e-11	-0.16	0.14	0.08	FALSE
15	GTEx	Artery Tibial	SCAND2P	0.12	0.05	enet	16	0.08	8.7e-07	-2.6	-6.6	4.6e-11	-0.32	0.65	0.06	FALSE
16	GTEx	Artery Tibial	AC103965.1	0.27	0.26	enet	31	0.30	1.8e-23	5.3	-8.1	4.5e-16	-0.34	1.00	0.00	FALSE
17	GTEx	Artery Tibial	CSPG4P11	0.16	0.24	lasso	4	0.23	3.0e-18	5.3	-7.2	5.1e-13	-0.26	1.00	0.00	FALSE
18	GTEx	Brain Cerebellar Hemisphere	CSPG4P11	0.30	0.21	lasso	3	0.16	7.6e-05	5.1	5.2	1.8e-07	0.21	0.39	0.08	FALSE
19	GTEx	Brain Cerebellum	GOLGA6L4	0.29	0.06	lasso	7	0.21	9.7e-07	-13.1	-7.0	3.3e-12	-0.14	0.28	0.06	FALSE
20	GTEx	Brain Cerebellum	AC103965.1	0.13	0.02	enet	21	0.01	2.1e-01	5.2	-8.5	2.3e-17	-0.31	0.04	0.71	FALSE
21	GTEx	Brain Cortex	BTBD1	0.33	0.13	lasso	5	0.22	7.9e-07	4.8	-6.0	1.4e-09	-0.23	0.16	0.22	FALSE
22	GTEx	Brain Cortex	GOLGA6L4	0.42	0.21	lasso	7	0.28	2.8e-08	-8.5	-10.6	3.3e-26	-0.24	0.63	0.06	TRUE
23	GTEx	Brain Cortex	AC103965.1	0.17	0.19	lasso	3	0.16	4.3e-05	5.0	-6.4	1.3e-10	-0.22	0.21	0.44	FALSE
24	GTEx	Brain Cortex	RP11-182J1.14	0.24	0.03	enet	14	0.16	3.2e-05	5.2	7.5	8.2e-14	0.34	0.07	0.21	FALSE
25	GTEx	Brain Frontal Cortex BA9	GOLGA6L4	0.33	0.15	lasso	7	0.34	5.8e-10	-8.5	-6.2	4.1e-10	-0.07	0.45	0.04	FALSE
26	GTEx	Brain Nucleus accumbens basal ganglia	C15orf40	0.19	-0.01	enet	21	0.03	4.6e-02	4.8	-5.4	6.9e-08	-0.20	0.04	0.29	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	GOLGA6L4	0.21	0.04	lasso	5	0.09	2.3e-03	-13.1	-9.4	7.1e-21	-0.24	0.06	0.06	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	AC103965.1	0.29	0.23	enet	21	0.27	6.9e-08	5.2	-6.6	5.2e-11	-0.20	0.86	0.08	FALSE
29	GTEx	Breast Mammary Tissue	GOLGA6L3	0.28	0.16	lasso	7	0.21	3.5e-11	-7.7	-5.1	2.9e-07	-0.10	0.00	1.00	FALSE
30	GTEx	Breast Mammary Tissue	AC103965.1	0.13	0.11	lasso	1	0.13	2.9e-07	5.3	-5.3	1.4e-07	-0.18	0.90	0.05	FALSE
31	GTEx	Breast Mammary Tissue (Male)	GOLGA6L4	0.23	0.07	lasso	2	0.12	8.3e-04	-8.5	-9.0	2.8e-19	-0.16	0.09	0.11	FALSE
32	GTEx	Breast Mammary Tissue (Male)	AC103965.1	0.24	0.14	lasso	4	0.11	1.4e-03	5.0	-8.1	6.7e-16	-0.26	0.12	0.28	FALSE
33	GTEx	Breast Mammary Tissue (Male)	RN7SL417P	0.20	0.12	lasso	3	0.10	3.1e-03	4.7	5.6	2.5e-08	0.29	0.06	0.12	FALSE
34	GTEx	Breast Mammary Tissue (Male)	RP11-182J1.14	0.04	-0.01	enet	1	-0.01	5.9e-01	5.2	5.2	2.2e-07	0.20	0.03	0.08	FALSE
35	GTEx	Cells Transformed fibroblasts	AC103965.1	0.15	0.09	lasso	7	0.11	1.3e-08	5.2	-9.0	3.0e-19	-0.21	0.98	0.01	FALSE
36	GTEx	Cells Transformed fibroblasts	CSPG4P11	0.19	0.18	enet	17	0.17	9.8e-13	5.2	-5.4	6.1e-08	-0.16	1.00	0.00	FALSE
37	GTEx	Colon Sigmoid	GOLGA6L4	0.63	0.16	lasso	10	0.31	1.7e-11	-7.8	-5.4	7.7e-08	-0.01	0.99	0.00	FALSE
38	GTEx	Colon Sigmoid	RN7SL417P	0.17	0.06	lasso	4	0.12	6.1e-05	5.2	6.2	5.5e-10	0.25	0.28	0.08	FALSE
39	GTEx	Colon Sigmoid	RP11-182J1.14	0.31	0.29	lasso	9	0.30	2.7e-11	5.2	6.1	8.6e-10	0.22	1.00	0.00	FALSE
40	GTEx	Colon Transverse	GOLGA6L4	0.40	0.30	lasso	10	0.37	2.0e-18	-8.5	-5.3	1.4e-07	-0.01	1.00	0.00	FALSE
41	GTEx	Colon Transverse	GOLGA6L3	0.18	0.17	lasso	4	0.14	2.2e-07	-7.7	-6.6	4.1e-11	-0.05	0.00	1.00	FALSE
42	GTEx	Colon Transverse	AC103965.1	0.15	0.07	enet	33	0.06	7.1e-04	-7.9	-6.8	7.4e-12	-0.09	0.17	0.15	FALSE
43	GTEx	Colon Transverse	CSPG4P11	0.10	0.10	lasso	4	0.08	1.2e-04	-7.9	-8.2	2.0e-16	-0.11	0.23	0.12	FALSE
44	GTEx	Esophagus Gastroesophageal Junction	GOLGA6L4	0.29	0.17	enet	9	0.28	1.1e-10	-8.5	-5.6	2.5e-08	-0.07	0.75	0.02	FALSE
45	GTEx	Esophagus Gastroesophageal Junction	RP11-382A20.2	0.13	0.03	enet	20	0.07	1.1e-03	5.3	6.7	2.8e-11	0.28	0.11	0.14	TRUE
46	GTEx	Esophagus Mucosa	UBE2Q2P1	0.38	0.26	enet	37	0.28	3.7e-19	5.3	7.7	9.9e-15	0.21	1.00	0.00	TRUE
47	GTEx	Esophagus Mucosa	AC103965.1	0.20	0.19	enet	47	0.16	8.4e-11	5.3	-7.1	1.6e-12	-0.24	1.00	0.00	FALSE
48	GTEx	Esophagus Mucosa	RP11-182J1.16	0.20	0.05	lasso	5	0.10	1.8e-07	5.2	-7.7	1.2e-14	-0.16	0.90	0.00	FALSE
49	GTEx	Esophagus Mucosa	CSPG4P11	0.21	0.01	enet	28	0.08	3.7e-06	-7.9	-6.6	4.9e-11	-0.21	0.86	0.04	FALSE
50	GTEx	Esophagus Muscularis	UBE2Q2P1	0.34	0.03	lasso	7	0.15	1.9e-09	2.6	7.1	1.1e-12	0.05	0.38	0.20	TRUE
51	GTEx	Esophagus Muscularis	AC103965.1	0.18	0.14	enet	16	0.14	7.6e-09	5.1	-6.9	4.1e-12	-0.22	1.00	0.00	FALSE
52	GTEx	Heart Atrial Appendage	RP11-182J1.14	0.06	0.05	lasso	3	0.05	3.6e-03	5.2	5.2	1.9e-07	0.21	0.18	0.24	FALSE
53	GTEx	Heart Left Ventricle	AC103965.1	0.16	0.13	enet	14	0.12	7.0e-07	5.2	-6.1	1.2e-09	-0.15	0.98	0.00	FALSE
54	GTEx	Heart Left Ventricle	CSPG4P11	0.11	0.02	lasso	5	0.00	2.2e-01	5.2	-5.3	1.3e-07	-0.15	0.18	0.07	FALSE
55	GTEx	Lung	AC103965.1	0.20	0.14	lasso	4	0.16	1.8e-12	5.3	-6.6	4.3e-11	-0.19	1.00	0.00	FALSE
56	GTEx	Muscle Skeletal	NMB	0.07	0.00	enet	23	0.00	9.9e-02	-4.8	-6.2	4.7e-10	-0.11	0.08	0.64	FALSE
57	GTEx	Muscle Skeletal	AC103965.1	0.22	0.14	enet	40	0.19	2.4e-18	5.0	-5.4	6.3e-08	-0.12	1.00	0.00	FALSE
58	GTEx	Nerve Tibial	UBE2Q2P1	0.13	0.01	enet	37	0.04	1.3e-03	5.3	7.3	3.4e-13	0.18	0.10	0.38	FALSE
59	GTEx	Nerve Tibial	AC103965.1	0.20	0.22	enet	17	0.27	5.1e-19	5.3	-8.2	2.9e-16	-0.28	1.00	0.00	FALSE
60	GTEx	Ovary	GOLGA6L4	0.39	0.21	enet	27	0.46	8.9e-13	-8.5	-5.5	4.0e-08	-0.02	0.66	0.02	FALSE
61	GTEx	Ovary	AC103965.1	0.27	0.22	lasso	3	0.24	1.6e-06	5.2	-5.5	5.1e-08	-0.12	0.37	0.06	FALSE
62	GTEx	Pancreas	AC103965.1	0.29	0.23	lasso	9	0.18	2.8e-08	5.2	-6.5	6.0e-11	-0.24	1.00	0.00	FALSE
63	GTEx	Pancreas	RP11-182J1.16	0.08	-0.01	enet	11	-0.01	7.9e-01	-7.9	-9.7	4.5e-22	-0.23	0.05	0.17	FALSE
64	GTEx	Pituitary	UBE2Q2P1	0.32	0.00	lasso	20	0.06	1.1e-02	-4.0	5.9	4.1e-09	0.11	0.02	0.81	FALSE
65	GTEx	Pituitary	AC103965.1	0.30	0.16	enet	10	0.24	8.4e-07	5.1	-7.8	4.6e-15	-0.27	0.40	0.21	FALSE
66	GTEx	Prostate	RP11-182J1.16	0.24	0.06	enet	27	0.08	6.2e-03	1.6	-11.2	2.6e-29	-0.32	0.09	0.10	TRUE
67	GTEx	Prostate	CSPG4P11	0.34	0.07	enet	13	0.18	2.3e-05	-4.8	-8.3	8.9e-17	-0.10	0.15	0.26	FALSE
68	GTEx	Skin Not Sun Exposed Suprapubic	GOLGA6L3	0.29	0.11	enet	17	0.22	1.8e-12	-4.2	-5.6	2.6e-08	-0.03	0.00	1.00	FALSE
69	GTEx	Skin Not Sun Exposed Suprapubic	AC103965.1	0.23	0.15	lasso	8	0.19	1.9e-10	5.2	-7.0	3.4e-12	-0.13	0.96	0.01	TRUE
70	GTEx	Skin Not Sun Exposed Suprapubic	RP11-182J1.16	0.10	0.01	enet	13	0.04	3.1e-03	1.8	-6.0	2.2e-09	-0.15	0.35	0.10	FALSE
71	GTEx	Skin Not Sun Exposed Suprapubic	CSPG4P11	0.29	0.07	enet	29	0.13	9.6e-08	5.2	-5.8	5.7e-09	-0.10	0.96	0.00	FALSE
72	GTEx	Skin Sun Exposed Lower leg	ZSCAN2	0.08	0.02	enet	13	0.03	1.4e-03	-8.0	7.6	3.7e-14	0.13	0.36	0.12	TRUE
73	GTEx	Skin Sun Exposed Lower leg	GOLGA6L4	0.51	0.23	enet	32	0.44	8.3e-40	-8.5	-6.2	4.9e-10	-0.10	1.00	0.00	FALSE
74	GTEx	Skin Sun Exposed Lower leg	AC103965.1	0.33	0.17	enet	24	0.23	4.8e-19	5.3	-8.7	5.3e-18	-0.23	1.00	0.00	FALSE
75	GTEx	Skin Sun Exposed Lower leg	RP11-182J1.16	0.09	0.04	enet	18	0.04	1.4e-04	5.2	-6.1	1.2e-09	-0.15	0.55	0.09	FALSE
76	GTEx	Skin Sun Exposed Lower leg	CSPG4P11	0.18	0.07	lasso	11	0.19	9.1e-16	1.8	-6.2	6.5e-10	-0.13	1.00	0.00	FALSE
77	GTEx	Small Intestine Terminal Ileum	RP11-182J1.14	0.26	0.01	enet	27	0.12	1.3e-03	-14.2	6.8	9.0e-12	0.40	0.02	0.63	TRUE
78	GTEx	Spleen	WDR73	0.17	0.02	lasso	4	0.03	5.8e-02	-8.0	-5.5	3.2e-08	0.02	0.07	0.19	FALSE
79	GTEx	Spleen	GOLGA6L4	0.55	0.20	enet	19	0.40	2.6e-11	-7.9	-8.8	1.4e-18	-0.15	0.89	0.01	FALSE
80	GTEx	Spleen	GOLGA6L5	0.46	0.34	lasso	9	0.40	2.0e-11	-4.3	-5.6	1.8e-08	-0.26	0.71	0.18	FALSE
81	GTEx	Stomach	GOLGA6L5	0.32	0.20	lasso	7	0.19	2.1e-09	-4.4	-5.6	2.5e-08	-0.27	0.98	0.00	FALSE
82	GTEx	Testis	BTBD1	0.06	0.01	enet	8	0.04	1.1e-02	4.3	-5.2	2.2e-07	-0.17	0.14	0.14	FALSE
83	GTEx	Testis	AC103965.1	0.07	0.07	lasso	2	0.06	1.6e-03	5.3	-5.2	2.5e-07	-0.17	0.52	0.03	TRUE
84	GTEx	Testis	RP11-182J1.14	0.10	0.19	lasso	1	0.17	6.7e-08	5.3	5.3	1.4e-07	0.18	0.94	0.00	FALSE
85	GTEx	Thyroid	GOLGA6L3	0.33	0.15	lasso	6	0.22	4.4e-17	-7.7	-5.4	8.4e-08	-0.03	0.00	1.00	FALSE
86	GTEx	Thyroid	AC103965.1	0.30	0.25	lasso	7	0.25	1.8e-19	5.2	-6.3	3.4e-10	-0.16	1.00	0.00	FALSE
87	GTEx	Thyroid	RP11-182J1.16	0.10	0.02	lasso	7	0.05	1.3e-04	-9.8	-9.2	5.0e-20	-0.16	0.51	0.09	FALSE
88	GTEx	Thyroid	CSPG4P11	0.17	0.08	enet	20	0.14	6.1e-11	5.3	-6.7	1.7e-11	-0.13	1.00	0.00	FALSE
89	GTEx	Whole Blood	GOLGA6L4	0.12	0.08	enet	16	0.11	2.1e-10	-7.6	-9.0	2.3e-19	-0.14	0.99	0.01	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOLGA6L5	0.04	0.04	enet	5	0.05	4.6e-11	-3.7	-7.7	1.3e-14	-0.25	0.68	0.32	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	GOLGA6L5	0.04	0.04	blup	7	0.03	8.2e-03	-4.5	-5.9	3.8e-09	-0.27	0.03	0.06	FALSE
92	The Cancer Genome Atlas	Esophageal Carcinoma	LOC388152	0.10	0.08	enet	2	0.08	1.8e-03	5.3	-5.3	1.3e-07	-0.18	0.00	0.72	FALSE
93	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC388152	0.12	0.08	lasso	3	0.08	1.9e-03	5.3	-5.3	1.5e-07	-0.16	0.00	0.64	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZSCAN2	0.11	0.00	blup	46	0.03	1.2e-04	4.2	5.4	6.8e-08	0.27	0.02	0.04	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GOLGA6L5	0.04	0.01	blup	7	0.03	4.9e-04	5.3	-6.0	2.5e-09	-0.26	0.06	0.08	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GOLGA6L5	0.06	0.06	blup	7	0.06	1.5e-04	-3.9	-5.7	1.1e-08	-0.29	0.06	0.07	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	GOLGA6L5	0.06	0.09	blup	7	0.09	1.5e-10	-4.5	-5.6	2.2e-08	-0.27	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBE2Q2P1	0.07	0.04	blup	22	0.06	1.8e-07	5.2	6.9	3.8e-12	0.12	0.08	0.92	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UBE2Q2P1	0.10	0.00	blup	22	0.03	1.9e-02	-9.3	7.5	8.8e-14	0.12	0.00	0.57	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	GOLGA6L5	0.05	0.04	blup	7	0.05	5.1e-07	-4.5	-7.5	7.3e-14	-0.24	0.10	0.68	FALSE
101	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC388152	0.02	0.03	lasso	1	0.02	1.2e-03	5.3	-5.3	1.3e-07	-0.18	0.00	0.91	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBE2Q2P1	0.03	0.03	lasso	3	0.02	9.2e-04	5.2	6.5	7.7e-11	0.20	0.02	0.59	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC388152	0.04	0.05	enet	2	0.05	4.2e-04	5.3	-5.3	1.3e-07	-0.18	0.00	0.87	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC388152	0.08	0.11	lasso	3	0.11	2.4e-05	5.3	-5.2	1.5e-07	-0.16	0.00	0.97	FALSE
105	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GOLGA6L5	0.10	0.04	enet	2	0.10	9.9e-05	-4.5	-5.8	7.2e-09	-0.23	0.02	0.10	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOLGA6L5	0.11	0.03	blup	7	0.09	5.5e-10	-4.5	-8.0	1.7e-15	-0.29	0.05	0.95	FALSE
107	The Cancer Genome Atlas	Soft Tissue Sarcoma	GOLGA6L5	0.09	0.08	enet	4	0.09	5.2e-06	-4.5	-8.8	1.3e-18	-0.29	0.01	0.89	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADAMTSL3	0.07	0.02	blup	153	0.02	9.8e-03	1.5	7.2	5.0e-13	0.05	0.20	0.06	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	GOLGA6L5	0.15	0.16	lasso	3	0.19	1.8e-18	-4.5	-5.5	2.9e-08	-0.23	1.00	0.00	FALSE