[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr16:74,270,536-76,281,066

Best TWAS P=1.2e-76 · Best GWAS P=3.51e-77 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CFDP1 0.08 0.04 lasso 4 0.04 1.6e-05 18.13 17.9 6.6e-72 0.92 0.03 0.97 FALSE
2 CommonMind Brain Pre-frontal Cortex TMEM231 0.07 0.03 enet 13 0.04 7.3e-06 1.64 -8.7 2.3e-18 -0.51 0.32 0.64 FALSE
3 CommonMind Brain Pre-frontal Cortex ZNRF1 0.07 0.03 bslmm 442 0.02 1.0e-03 4.40 -7.3 4.0e-13 -0.28 0.56 0.04 FALSE
4 GTEx Adipose Subcutaneous CFDP1 0.11 0.09 lasso 2 0.09 1.1e-07 11.10 11.1 1.2e-28 0.65 0.67 0.32 TRUE
5 GTEx Adipose Subcutaneous TMEM170A 0.11 0.00 lasso 5 0.01 6.7e-02 15.11 16.3 9.5e-60 0.79 0.02 0.94 FALSE
6 GTEx Adipose Visceral Omentum CFDP1 0.20 0.09 lasso 4 0.08 5.2e-05 10.14 9.6 1.2e-21 0.60 0.34 0.40 FALSE
7 GTEx Adrenal Gland TMEM170A 0.11 0.06 enet 4 0.04 1.7e-02 18.44 -18.5 1.2e-76 -0.99 0.02 0.94 TRUE
8 GTEx Artery Aorta BCAR1 0.18 0.13 lasso 3 0.11 9.8e-07 18.44 -18.2 4.5e-74 -0.98 0.02 0.98 FALSE
9 GTEx Artery Aorta CFDP1 0.16 0.00 enet 10 0.01 5.3e-02 11.60 -10.2 1.4e-24 -0.42 0.11 0.11 FALSE
10 GTEx Artery Tibial BCAR1 0.07 0.06 lasso 1 0.04 2.4e-04 18.04 -18.0 9.1e-73 -0.98 0.03 0.95 FALSE
11 GTEx Brain Cerebellum BCAR1 0.18 0.08 enet 12 0.09 1.1e-03 18.28 17.0 6.3e-65 0.76 0.03 0.86 TRUE
12 GTEx Brain Cerebellum CFDP1 0.25 -0.01 lasso 2 0.05 1.7e-02 18.44 14.7 4.6e-49 0.81 0.02 0.89 FALSE
13 GTEx Brain Cortex CFDP1 0.18 0.07 lasso 3 0.08 3.4e-03 10.38 12.9 2.7e-38 0.76 0.03 0.82 FALSE
14 GTEx Breast Mammary Tissue (Female) CFDP1 0.07 0.05 lasso 1 0.05 1.5e-02 10.30 10.3 6.8e-25 0.64 0.05 0.42 FALSE
15 GTEx Cells EBV-transformed lymphocytes TMEM170A 0.13 0.07 lasso 3 0.02 6.2e-02 15.16 13.5 1.5e-41 0.77 0.04 0.76 FALSE
16 GTEx Cells Transformed fibroblasts CFDP1 0.17 0.20 enet 10 0.24 9.9e-18 18.28 18.3 5.1e-75 0.95 0.02 0.98 FALSE
17 GTEx Colon Transverse CFDP1 0.14 0.11 lasso 2 0.08 7.6e-05 10.38 8.9 7.0e-19 0.57 0.55 0.04 FALSE
18 GTEx Esophagus Gastroesophageal Junction CFDP1 0.31 0.17 lasso 4 0.16 3.0e-06 10.94 10.3 9.5e-25 0.60 0.50 0.44 FALSE
19 GTEx Esophagus Mucosa BCAR1 0.16 0.13 lasso 8 0.14 1.8e-09 18.45 17.7 8.3e-70 0.96 0.02 0.98 FALSE
20 GTEx Esophagus Muscularis CFDP1 0.18 0.12 lasso 5 0.09 3.1e-06 10.38 10.0 2.5e-23 0.61 0.99 0.00 FALSE
21 GTEx Muscle Skeletal CFDP1 0.05 0.05 enet 4 0.04 3.4e-05 10.76 10.8 4.7e-27 0.64 0.44 0.51 FALSE
22 GTEx Nerve Tibial CFDP1 0.16 0.14 lasso 3 0.12 1.6e-08 11.10 13.9 5.6e-44 0.79 0.11 0.89 FALSE
23 GTEx Nerve Tibial TMEM170A 0.12 0.09 enet 7 0.11 4.1e-08 11.89 16.9 5.0e-64 0.87 0.12 0.88 FALSE
24 GTEx Pancreas CFDP1 0.16 0.07 lasso 2 0.12 1.2e-05 10.30 10.9 7.2e-28 0.62 0.45 0.20 FALSE
25 GTEx Skin Not Sun Exposed Suprapubic CFDP1 0.12 0.06 enet 14 0.06 5.2e-04 10.38 8.2 2.5e-16 0.54 0.15 0.26 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic TMEM170A 0.09 0.02 lasso 3 0.05 1.1e-03 6.56 -9.0 2.6e-19 -0.63 0.11 0.74 FALSE
27 GTEx Skin Sun Exposed Lower leg CFDP1 0.17 0.13 enet 25 0.11 2.8e-09 11.10 8.9 5.8e-19 0.58 0.99 0.01 TRUE
28 GTEx Skin Sun Exposed Lower leg TMEM170A 0.13 0.08 lasso 5 0.06 1.2e-05 15.16 -12.0 5.4e-33 -0.75 0.21 0.77 FALSE
29 GTEx Thyroid TMEM170A 0.09 0.02 lasso 4 0.00 4.0e-01 12.47 12.5 4.7e-36 0.60 0.07 0.71 TRUE
30 METSIM Adipose TMEM170A 0.03 0.01 lasso 3 0.02 1.5e-03 18.22 16.8 2.7e-63 0.87 0.03 0.97 FALSE
31 YFS Blood CFDP1 0.21 0.26 bslmm 396 0.30 1.5e-99 10.38 8.4 6.0e-17 0.55 1.00 0.00 TRUE
32 YFS Blood TMEM170A 0.03 0.02 lasso 2 0.02 1.2e-06 7.72 6.9 5.5e-12 0.31 0.99 0.00 FALSE
33 YFS Blood WDR59 0.07 0.01 bslmm 422 0.03 6.4e-10 -0.37 9.1 1.1e-19 0.34 0.79 0.10 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma CFDP1 0.04 0.03 enet 10 0.03 5.2e-07 11.10 12.0 6.4e-33 0.66 0.93 0.07 FALSE
35 The Cancer Genome Atlas Colon Adenocarcinoma CFDP1 0.10 0.04 blup 71 0.06 1.8e-04 10.76 8.3 9.4e-17 0.57 0.30 0.18 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CFDP1 0.02 0.02 lasso 4 0.02 1.9e-03 17.95 16.9 3.9e-64 0.93 0.02 0.91 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CFDP1 0.03 0.00 blup 71 0.01 1.1e-02 10.94 7.5 7.7e-14 0.56 0.09 0.10 FALSE
38 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CFDP1 0.13 0.07 enet 10 0.10 2.1e-06 10.94 7.2 4.9e-13 0.57 0.34 0.40 TRUE
39 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM170A 0.08 0.10 blup 36 0.13 9.1e-08 14.28 17.1 8.8e-66 0.90 0.02 0.98 FALSE
40 The Cancer Genome Atlas Brain Lower Grade Glioma CFDP1 0.04 0.02 lasso 6 0.03 4.0e-04 10.14 15.1 1.0e-51 0.86 0.03 0.96 FALSE
41 The Cancer Genome Atlas Lung Adenocarcinoma BCAR1 0.04 0.02 enet 8 0.03 5.1e-04 -5.85 5.8 4.9e-09 0.36 0.05 0.04 TRUE
42 The Cancer Genome Atlas Lung Adenocarcinoma CFDP1 0.05 0.02 enet 11 0.04 2.0e-05 10.94 7.7 1.7e-14 0.35 0.31 0.09 TRUE
43 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CFDP1 0.06 0.03 lasso 3 0.03 1.1e-04 6.02 7.8 4.9e-15 0.55 0.49 0.08 FALSE
44 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CFDP1 0.23 0.00 blup 70 0.02 4.2e-02 10.94 12.5 4.6e-36 0.66 0.02 0.28 TRUE
45 The Cancer Genome Atlas Prostate Adenocarcinoma CFDP1 0.06 0.05 enet 6 0.05 3.2e-06 10.30 7.4 2.0e-13 0.48 0.96 0.01 FALSE
46 The Cancer Genome Atlas Testicular Germ Cell Tumors CFDP1 0.10 0.00 blup 70 0.04 1.4e-02 17.95 14.7 3.7e-49 0.88 0.02 0.53 FALSE
47 The Cancer Genome Atlas Testicular Germ Cell Tumors CHST6 0.20 0.08 enet 10 0.10 2.2e-04 16.16 -15.5 4.5e-54 -0.86 0.02 0.86 FALSE
48 The Cancer Genome Atlas Thyroid Carcinoma CFDP1 0.09 0.02 lasso 4 0.04 9.8e-05 7.72 9.2 2.7e-20 0.50 0.23 0.08 FALSE