[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr16:74,270,536-76,281,066

Best TWAS P=1.2e-76 · Best GWAS P=3.51e-77 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Adrenal Gland	TMEM170A	0.11	0.06	enet	4	0.04	1.7e-02	18.44	-18.5	1.2e-76	-0.99	0.02	0.94	TRUE
11	GTEx	Brain Cerebellum	BCAR1	0.18	0.08	enet	12	0.09	1.1e-03	18.28	17.0	6.3e-65	0.76	0.03	0.86	TRUE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CFDP1	0.23	0.00	blup	70	0.02	4.2e-02	10.94	12.5	4.6e-36	0.66	0.02	0.28	TRUE
29	GTEx	Thyroid	TMEM170A	0.09	0.02	lasso	4	0.00	4.0e-01	12.47	12.5	4.7e-36	0.60	0.07	0.71	TRUE
4	GTEx	Adipose Subcutaneous	CFDP1	0.11	0.09	lasso	2	0.09	1.1e-07	11.10	11.1	1.2e-28	0.65	0.67	0.32	TRUE
27	GTEx	Skin Sun Exposed Lower leg	CFDP1	0.17	0.13	enet	25	0.11	2.8e-09	11.10	8.9	5.8e-19	0.58	0.99	0.01	TRUE
31	YFS	Blood	CFDP1	0.21	0.26	bslmm	396	0.30	1.5e-99	10.38	8.4	6.0e-17	0.55	1.00	0.00	TRUE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	CFDP1	0.05	0.02	enet	11	0.04	2.0e-05	10.94	7.7	1.7e-14	0.35	0.31	0.09	TRUE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CFDP1	0.13	0.07	enet	10	0.10	2.1e-06	10.94	7.2	4.9e-13	0.57	0.34	0.40	TRUE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	BCAR1	0.04	0.02	enet	8	0.03	5.1e-04	-5.85	5.8	4.9e-09	0.36	0.05	0.04	TRUE
16	GTEx	Cells Transformed fibroblasts	CFDP1	0.17	0.20	enet	10	0.24	9.9e-18	18.28	18.3	5.1e-75	0.95	0.02	0.98	FALSE
8	GTEx	Artery Aorta	BCAR1	0.18	0.13	lasso	3	0.11	9.8e-07	18.44	-18.2	4.5e-74	-0.98	0.02	0.98	FALSE
10	GTEx	Artery Tibial	BCAR1	0.07	0.06	lasso	1	0.04	2.4e-04	18.04	-18.0	9.1e-73	-0.98	0.03	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CFDP1	0.08	0.04	lasso	4	0.04	1.6e-05	18.13	17.9	6.6e-72	0.92	0.03	0.97	FALSE
19	GTEx	Esophagus Mucosa	BCAR1	0.16	0.13	lasso	8	0.14	1.8e-09	18.45	17.7	8.3e-70	0.96	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM170A	0.08	0.10	blup	36	0.13	9.1e-08	14.28	17.1	8.8e-66	0.90	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CFDP1	0.02	0.02	lasso	4	0.02	1.9e-03	17.95	16.9	3.9e-64	0.93	0.02	0.91	FALSE
23	GTEx	Nerve Tibial	TMEM170A	0.12	0.09	enet	7	0.11	4.1e-08	11.89	16.9	5.0e-64	0.87	0.12	0.88	FALSE
30	METSIM	Adipose	TMEM170A	0.03	0.01	lasso	3	0.02	1.5e-03	18.22	16.8	2.7e-63	0.87	0.03	0.97	FALSE
5	GTEx	Adipose Subcutaneous	TMEM170A	0.11	0.00	lasso	5	0.01	6.7e-02	15.11	16.3	9.5e-60	0.79	0.02	0.94	FALSE
47	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHST6	0.20	0.08	enet	10	0.10	2.2e-04	16.16	-15.5	4.5e-54	-0.86	0.02	0.86	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	CFDP1	0.04	0.02	lasso	6	0.03	4.0e-04	10.14	15.1	1.0e-51	0.86	0.03	0.96	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CFDP1	0.10	0.00	blup	70	0.04	1.4e-02	17.95	14.7	3.7e-49	0.88	0.02	0.53	FALSE
12	GTEx	Brain Cerebellum	CFDP1	0.25	-0.01	lasso	2	0.05	1.7e-02	18.44	14.7	4.6e-49	0.81	0.02	0.89	FALSE
22	GTEx	Nerve Tibial	CFDP1	0.16	0.14	lasso	3	0.12	1.6e-08	11.10	13.9	5.6e-44	0.79	0.11	0.89	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	TMEM170A	0.13	0.07	lasso	3	0.02	6.2e-02	15.16	13.5	1.5e-41	0.77	0.04	0.76	FALSE
13	GTEx	Brain Cortex	CFDP1	0.18	0.07	lasso	3	0.08	3.4e-03	10.38	12.9	2.7e-38	0.76	0.03	0.82	FALSE
28	GTEx	Skin Sun Exposed Lower leg	TMEM170A	0.13	0.08	lasso	5	0.06	1.2e-05	15.16	-12.0	5.4e-33	-0.75	0.21	0.77	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	CFDP1	0.04	0.03	enet	10	0.03	5.2e-07	11.10	12.0	6.4e-33	0.66	0.93	0.07	FALSE
24	GTEx	Pancreas	CFDP1	0.16	0.07	lasso	2	0.12	1.2e-05	10.30	10.9	7.2e-28	0.62	0.45	0.20	FALSE
21	GTEx	Muscle Skeletal	CFDP1	0.05	0.05	enet	4	0.04	3.4e-05	10.76	10.8	4.7e-27	0.64	0.44	0.51	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CFDP1	0.07	0.05	lasso	1	0.05	1.5e-02	10.30	10.3	6.8e-25	0.64	0.05	0.42	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CFDP1	0.31	0.17	lasso	4	0.16	3.0e-06	10.94	10.3	9.5e-25	0.60	0.50	0.44	FALSE
9	GTEx	Artery Aorta	CFDP1	0.16	0.00	enet	10	0.01	5.3e-02	11.60	-10.2	1.4e-24	-0.42	0.11	0.11	FALSE
20	GTEx	Esophagus Muscularis	CFDP1	0.18	0.12	lasso	5	0.09	3.1e-06	10.38	10.0	2.5e-23	0.61	0.99	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	CFDP1	0.20	0.09	lasso	4	0.08	5.2e-05	10.14	9.6	1.2e-21	0.60	0.34	0.40	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	CFDP1	0.09	0.02	lasso	4	0.04	9.8e-05	7.72	9.2	2.7e-20	0.50	0.23	0.08	FALSE
33	YFS	Blood	WDR59	0.07	0.01	bslmm	422	0.03	6.4e-10	-0.37	9.1	1.1e-19	0.34	0.79	0.10	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	TMEM170A	0.09	0.02	lasso	3	0.05	1.1e-03	6.56	-9.0	2.6e-19	-0.63	0.11	0.74	FALSE
17	GTEx	Colon Transverse	CFDP1	0.14	0.11	lasso	2	0.08	7.6e-05	10.38	8.9	7.0e-19	0.57	0.55	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM231	0.07	0.03	enet	13	0.04	7.3e-06	1.64	-8.7	2.3e-18	-0.51	0.32	0.64	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	CFDP1	0.10	0.04	blup	71	0.06	1.8e-04	10.76	8.3	9.4e-17	0.57	0.30	0.18	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	CFDP1	0.12	0.06	enet	14	0.06	5.2e-04	10.38	8.2	2.5e-16	0.54	0.15	0.26	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CFDP1	0.06	0.03	lasso	3	0.03	1.1e-04	6.02	7.8	4.9e-15	0.55	0.49	0.08	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CFDP1	0.03	0.00	blup	71	0.01	1.1e-02	10.94	7.5	7.7e-14	0.56	0.09	0.10	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	CFDP1	0.06	0.05	enet	6	0.05	3.2e-06	10.30	7.4	2.0e-13	0.48	0.96	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNRF1	0.07	0.03	bslmm	442	0.02	1.0e-03	4.40	-7.3	4.0e-13	-0.28	0.56	0.04	FALSE
32	YFS	Blood	TMEM170A	0.03	0.02	lasso	2	0.02	1.2e-06	7.72	6.9	5.5e-12	0.31	0.99	0.00	FALSE