[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:119,497,419-121,675,485

Best TWAS P=1.73e-09 · Best GWAS P=2.09e-08 conditioned to 0.215

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial TMEM185B 0.07 0.06 lasso 5 0.04 3.4e-04 4.7 5.2 2.3e-07 0.72 0.13 0.80 FALSE
2 GTEx Brain Cerebellar Hemisphere EPB41L5 0.33 0.22 lasso 16 0.20 1.0e-05 5.6 -5.6 1.8e-08 -0.98 0.04 0.93 FALSE
3 GTEx Brain Cerebellum PTPN4 0.15 0.09 lasso 4 0.04 1.9e-02 5.0 -5.6 1.7e-08 -0.86 0.08 0.78 FALSE
4 GTEx Brain Cerebellum AC012363.4 0.34 0.06 lasso 5 0.08 1.9e-03 5.0 -5.6 1.7e-08 -0.89 0.05 0.80 FALSE
5 GTEx Cells Transformed fibroblasts PTPN4 0.06 0.02 lasso 2 0.03 1.5e-03 5.6 5.9 4.1e-09 0.99 0.04 0.95 FALSE
6 GTEx Skin Sun Exposed Lower leg TMEM37 0.08 0.03 lasso 5 0.01 1.0e-01 4.9 6.0 1.7e-09 0.32 0.12 0.46 TRUE
7 GTEx Testis TMEM185B 0.12 0.09 enet 10 0.12 5.7e-06 4.7 5.4 6.2e-08 0.77 0.15 0.83 TRUE
8 METSIM Adipose TMEM37 0.05 0.01 bslmm 411 0.02 1.3e-03 4.5 5.9 3.1e-09 0.23 0.24 0.11 FALSE
9 YFS Blood PTPN4 0.02 0.01 lasso 2 0.02 1.8e-06 5.5 -5.3 9.3e-08 -0.84 0.04 0.95 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM185B 0.03 0.03 lasso 3 0.02 5.2e-03 5.2 5.3 9.5e-08 0.79 0.00 0.90 FALSE
11 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM37 0.06 0.00 blup 58 0.02 2.4e-02 -3.9 5.7 1.6e-08 0.00 0.02 0.32 FALSE
12 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM185B 0.07 0.03 blup 21 0.03 1.3e-02 5.2 5.2 1.7e-07 0.73 0.01 0.74 FALSE