Hub : Genes

SETD7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.214 0.0850 9.0e-03 -0.013 NA -0.013 NA -0.012 9.8e-01 NA 9.3e-01 NA 8.7e-01
2 GTEx Esophagus Muscularis 0.130 0.0500 5.8e-04 0.046 NA -0.002 NA 0.019 8.3e-04 NA 4.6e-01 NA 2.2e-02
3 GTEx Muscle Skeletal 0.264 0.0537 9.1e-09 0.133 NA 0.109 NA 0.127 5.7e-13 NA 7.6e-11 NA 2.1e-12
4 GTEx Testis 0.165 0.0650 2.5e-03 0.006 NA 0.020 NA 0.014 1.7e-01 NA 4.2e-02 NA 7.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 1.0 3.7 -1.9 -0.4 0.3 0.0
Bipolar Disorder or Schizophrenia 0.3 0.8 2.2 -1.5 -0.8 -0.3 0.7
Depressed Affect (Nagel 2018) 2.3 4.9 12.2 -3.5 -2.6 -0.5 0.4
Depression (Nagel 2018) 2.6 3.9 14.8 -3.8 -0.2 0.9 0.2
Intelligence (Savage-Jansen 2018) 0.4 1.4 3.0 1.3 -0.2 1.7 -0.9
Neuroticism (Nagel 2018) 0.7 1.6 3.9 -2.0 -1.5 0.1 0.0
Schizophrenia (2018) 0.3 0.5 1.1 -0.3 -0.7 -0.6 1.0
Schizophrenia vs Biploar Disorder 1.9 2.5 6.4 2.5 0.2 -0.5 -1.8
Worry (Nagel 2018) 0.6 1.2 3.2 0.4 -1.8 -0.6 1.0
Alzheimer’s Disease (in mother) 0.8 1.0 1.7 -1.3 -1.1 -0.8 0.5
Alzheimer’s Disease (in father) 2.6 2.8 5.1 -0.7 -2.0 -1.2 2.3
Alzheimer’s Disease (including proxy) 2.1 3.0 6.3 -1.4 -2.5 -1.3 1.4
Crohns Disease (2017) 0.6 1.3 2.8 -1.7 -1.1 0.6 1.0
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 -0.9 -0.4 0.7 0.3
Ulcerative Colitis (UC) 0.2 0.5 0.8 -0.2 0.6 0.9 -0.8
Major Depression (MDD) 1.9 2.4 4.7 -2.2 1.3 1.8 0.2
Reaction Time 0.5 1.0 2.2 1.5 0.8 0.9 0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.7 0.5 -0.9 0.2 0.1
Breast Cancer 0.4 1.0 3.5 0.4 -1.9 -0.4 -0.3
Ovarian Cancer 1.6 2.1 7.2 0.0 -0.9 -0.4 2.7
Prostate Cancer 0.2 0.3 0.6 0.3 0.8 0.6 0.2
Age at First Birth 2.4 3.5 5.7 2.4 1.3 1.9 -1.7
Bipolar Disorder (2011) 1.4 1.3 3.7 -1.9 0.7 1.1 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 4.7 0.2 -2.2 -0.3 1.1
Coronary Artery Disease (CAD) 1.0 1.2 4.1 0.3 -2.0 -0.5 0.7
Crohns Disease (2012) 1.0 1.6 4.6 -2.2 -0.8 1.0 0.1
Mean Putamen Volume 0.4 0.5 1.1 -0.7 -0.5 -0.2 1.0
Fasting Glucose 1.0 1.2 2.5 1.1 -0.6 1.6 0.9
HbA1C 1.2 1.3 4.8 0.2 -0.5 2.2 0.1
HDL Cholesterol 0.6 1.0 2.8 -0.4 0.9 1.7 -0.2
LDL Cholesterol 0.3 0.5 1.4 0.4 0.4 1.2 -0.7
Lupus 0.5 0.7 1.4 0.4 -1.2 -0.7 0.9
Neuroticism (2016) 0.5 0.7 2.6 -1.6 0.1 -0.4 -0.2
Primary Biliary Cirrhosis 0.2 0.3 0.6 0.8 -0.6 -0.2 -0.4
Rheumatoid Arthritis 1.2 1.6 3.8 -0.8 -2.0 -1.4 -0.2
Schizophrenia (2014) 0.1 0.2 0.5 -0.7 -0.1 0.5 0.4
Triglycerides 0.2 0.3 0.5 -0.1 -0.6 -0.4 0.7
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.8 -0.4 -1.7 -0.0 -1.3
Ulcerative Colitis 0.4 0.6 1.2 0.6 0.1 1.0 -1.1
Blood Eosinophil Count 0.2 1.6 2.6 -1.6 1.5 1.1 -0.6
Blood Platelet Count 0.1 0.6 1.1 1.0 -0.1 0.5 1.0
Blood Red Count 0.1 0.9 2.3 0.7 -1.5 0.2 0.9
Blood White Count 0.4 2.6 6.2 -2.5 1.3 1.5 -0.5
Heel T-Score 0.3 2.3 7.8 0.5 2.8 0.4 -0.9
BMI 0.7 4.0 11.9 -3.4 -1.8 -0.3 1.0
Height 0.4 7.1 14.5 3.8 -2.7 -2.0 1.7
Waist Hip Ratio (WHR) 1.4 6.3 16.2 -1.4 2.6 0.5 -4.0
Systolic Blood Pressure 0.1 0.7 1.5 -0.5 -1.2 1.0 0.3
Smoking Status 3.1 7.3 23.1 -4.8 2.1 1.3 0.5
Allergy or Eczema 0.9 2.5 5.1 1.1 -2.3 -1.9 0.4
Cardiovascular Disease 0.1 0.4 1.7 -1.3 -0.2 -0.1 -0.1
Hypothyroidism (self reported) 0.1 0.3 0.5 -0.1 0.7 0.4 0.7
Respiratory disease 1.5 3.2 8.8 -3.0 1.4 1.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.7 1.2 3.0 -1.4 -0.3 -0.1 1.7
Lung FEV1/FVC ratio 5.9 29.9 51.0 0.9 -7.1 -6.9 4.5
Lung FVC 0.3 1.4 3.0 1.7 0.5 -0.2 -1.5
Neuroticism 0.3 0.8 2.3 -1.5 -0.7 -0.0 -0.4
Chronotype (morning person) 0.9 2.1 5.5 1.5 -0.6 -0.5 2.3
Hair Pigment 0.0 1.4 2.2 -0.3 -1.5 -1.4 1.2
Tanning 0.0 0.1 0.1 0.1 0.3 -0.3 0.1
Hand grip strength (left) 0.5 1.4 3.6 0.9 -0.9 -1.9 0.6
Number of treatments/medications taken 1.3 2.3 4.9 -2.2 0.4 2.0 -0.1
Average weekly spirits intake 0.8 0.9 2.1 0.8 -0.8 1.5 0.6
Sensitivity / hurt feelings 0.2 0.3 1.0 -0.0 0.3 0.4 -1.0
Frequency of depressed mood in last 2 weeks 2.4 3.4 11.1 -3.3 0.1 0.3 1.5
Hearing difficulty/problems: Yes 2.2 3.4 6.1 0.4 2.5 1.7 -2.1
Relative age of first facial hair 0.7 1.4 3.3 0.8 1.8 0.8 -0.9
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 5.3 -1.8 -1.3 -2.3 0.3
Ever used hormone-replacement therapy (HRT) 1.4 1.7 3.3 -1.1 -1.3 -1.8 0.8
Ever had hysterectomy (womb removed) 1.5 1.7 2.5 -1.6 -1.4 1.5 -0.1
Systolic blood pressure, automated reading 0.1 0.4 0.9 -0.1 -0.6 0.9 0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 -0.5 0.2 -0.1 0.9
Angina 1.7 2.2 3.4 -1.5 0.6 -1.7 1.8
Medication for hormone replacement therapy 1.1 1.3 3.3 -0.7 -1.8 -1.0 0.4
Vitamin and mineral supplements 0.9 1.2 3.3 -0.4 0.8 1.8 -0.9
Supplements: Zinc 0.8 0.9 2.2 -1.5 0.9 -0.7 -0.4
Medication: Co-codamol 0.3 0.4 1.2 -1.1 -0.3 0.1 0.5
Medication: Metformin 0.7 1.0 1.7 -1.3 0.8 1.3 0.4
Diabetes (father) 1.9 2.3 4.9 1.4 -1.5 -0.3 2.2
Diabetes (mother) 0.9 1.1 3.3 0.2 -1.1 0.2 1.8
Severe depression (siblings) 0.7 0.8 2.0 -1.0 -0.0 1.4 0.4
Pack years adult smoking proportion 1.1 1.6 3.7 -1.9 0.1 -1.5 -0.8
Impedance of leg (right) 0.3 1.4 3.4 0.1 -1.2 -1.9 0.9
Leg fat-free mass (left) 0.0 0.2 0.8 0.1 -0.9 0.2 -0.3
Trunk fat percentage 1.0 4.0 4.7 -2.2 -2.1 -1.8 2.0
Hand grip strength (right) 0.4 1.0 2.2 1.5 -0.7 -1.2 0.2
Townsend deprivation index at recruitment 0.3 0.5 1.0 -0.8 0.2 1.0 -0.5
Current tobacco smoking 2.1 3.5 6.1 -2.5 2.3 0.9 -1.3
Average weekly fortified wine intake 0.2 0.2 0.4 0.6 -0.6 -0.2 0.1
Maternal smoking around birth 1.7 2.4 7.2 -2.7 1.5 0.1 0.4
Fed-up feelings 0.8 1.5 3.5 -1.9 -1.1 -1.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 6.2 -2.5 -0.2 1.1 -0.2
Relative age voice broke 0.2 0.3 0.4 0.4 0.5 0.6 -0.5
Taking other prescription medications 1.6 2.4 7.1 -2.7 1.3 0.9 -0.4
Age when periods started (menarche) 0.1 0.2 0.6 -0.8 0.2 0.2 -0.2
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 2.8 -1.7 -1.4 1.4 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.5 1.2 0.8 -0.5 -0.2
Tinnitus: Yes, but not now, but have in the past 2.8 3.0 6.7 -2.6 1.2 1.7 -1.1
Qualifications: CSEs or equivalent 0.8 1.1 2.1 -1.5 1.0 1.0 -0.5
Serious illness, injury or assault to yourself 2.1 2.5 9.7 -3.1 -0.3 -0.4 0.3
High blood pressure 0.1 0.3 0.9 -1.0 -0.3 0.3 0.4
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.1 1.1 -1.4 -0.8 -0.7
Multivitamins +/- minerals 1.5 1.9 3.2 1.8 -0.9 -1.7 0.7
Stomach or abdominal pain in last month 1.7 2.1 5.0 -2.2 -0.4 -1.7 0.5
Supplements: Glucosamine 0.5 0.6 1.5 0.3 -0.6 0.8 -1.2
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 6.2 0.2 -1.0 -0.2 2.5
Medication: Atenolol 1.1 1.4 3.4 -1.3 0.5 0.4 1.8
Medication: Levothyroxine sodium 0.4 0.7 1.9 1.4 0.6 0.8 -0.2
Sitting height 0.1 0.4 1.1 1.1 -0.6 0.2 -0.4
Chronic bronchitis/emphysema (father) 1.9 2.2 3.9 -2.0 1.6 0.9 -1.3
High blood pressure (mother) 2.2 3.1 5.6 2.4 1.2 -0.4 -2.3
Body mass index (BMI) 0.6 2.7 6.2 -2.5 -1.4 -0.7 1.5
Impedance of leg (left) 0.2 1.1 3.8 -0.1 -0.4 -2.0 0.7
Leg predicted mass (left) 0.0 0.3 0.8 0.1 -0.9 0.2 -0.5
Trunk fat mass 0.7 2.9 3.8 -1.7 -2.0 -1.3 1.7
Waist circumference 0.2 0.8 2.6 -1.6 0.2 0.1 -0.8
Number of incorrect matches in round 1.0 1.6 2.2 1.3 1.3 1.5 -0.9
Past tobacco smoking 3.2 5.8 13.1 3.6 -2.6 -1.8 -0.5
Alcohol usually taken with meals 1.4 2.2 4.1 -1.6 -1.1 -2.0 1.1
Nervous feelings 0.7 1.2 1.9 1.3 -1.0 -0.6 1.4
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.5 9.1 -3.0 -1.5 -0.5 1.6
Hearing difficulty/problems with background noise 2.7 4.3 7.4 -0.6 2.7 1.9 -2.3
Hair/balding pattern: Pattern 2 0.9 1.1 2.8 -0.6 -1.1 0.2 1.7
Had menopause 0.4 0.5 1.5 -0.4 -0.1 0.7 -1.2
Had other major operations 4.3 5.2 17.1 -4.1 0.3 1.9 -0.5
Forced vital capacity (FVC) 0.6 2.3 7.8 2.8 -0.8 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 0.9 0.4 -0.5 -0.1
Ever unenthusiastic/disinterested for a whole week 2.4 3.0 7.8 -2.8 0.8 1.7 -0.7
Qualifications: None of the above 0.1 0.2 0.5 -0.3 0.7 0.1 -0.4
Financial difficulties in last 2 years 2.5 3.4 12.1 -3.5 -0.1 1.1 0.4
Mouth/teeth dental problems 0.1 0.2 0.6 -0.1 -0.2 0.8 0.5
Heart attack 1.5 1.9 5.8 -2.4 0.9 0.6 -0.8
Allergy 0.2 0.5 1.7 0.5 -0.3 -0.4 1.3
Pain all over the body in last month 1.8 2.0 5.2 0.1 -1.6 0.4 2.3
Diabetes (self-reported) 0.6 0.9 3.4 -0.1 -0.4 0.2 1.8
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.2 0.1 -0.9 -0.8 -1.1
Medication: Ramipril 0.7 0.9 2.8 -0.1 0.6 1.7 -0.4
Medication: Simvastatin 0.5 0.8 1.7 -1.3 0.7 1.0 -0.2
Fluid intelligence score 0.5 1.0 2.8 1.7 -0.5 -0.0 -1.0
Illnesses of siblings 0.9 1.2 2.4 1.6 -0.1 1.4 -0.8
Neuroticism score 0.4 0.9 2.4 -1.6 -0.9 -0.4 0.2
Weight 0.2 1.1 1.9 -1.1 -1.4 -0.6 0.9
Impedance of arm (right) 0.4 2.1 3.9 0.5 -1.7 -2.0 1.0
Arm fat percentage (right) 1.0 4.0 5.4 -2.2 -2.0 -1.3 2.3
Trunk fat-free mass 0.1 0.6 1.4 1.2 0.3 0.5 -0.9
Hip circumference 0.4 1.7 3.6 -1.1 -1.9 -0.5 1.3
Time employed in main current job 0.6 0.7 1.4 1.2 0.3 -0.3 -1.0
Alcohol intake versus 10 years previously 6.7 10.1 13.7 -3.7 -2.8 -2.9 3.2
Father’s age at death 0.4 0.6 1.1 -0.1 1.0 -0.9 -0.6
Worrier / anxious feelings 0.2 0.4 0.6 -0.8 -0.6 -0.7 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.3 -1.5 -0.9 0.5 0.2
Falls in the last year 0.3 0.4 1.3 -0.4 -1.2 -0.1 0.0
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 1.5 -0.1 0.1 -1.1
Number of live births 0.7 1.0 2.9 1.0 1.7 -0.3 -0.5
Forced expiratory volume in 1-second (FEV1) 2.1 7.2 11.7 3.4 -2.9 -2.9 0.5
Pulse rate 0.1 0.3 0.8 0.2 0.3 0.9 -0.2
Happiness 1.1 1.3 3.8 -1.9 0.9 -0.0 -0.8
Noisy workplace 0.7 0.8 2.5 -0.2 0.9 -0.0 -1.6
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 0.7 0.7 -0.0 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 3.0 -0.5 1.7 -0.3 -1.0
Mouth/teeth dental problems: Dentures 0.7 1.2 1.8 1.3 1.0 1.3 -0.6
Asthma 2.0 3.9 6.1 -2.5 1.7 2.4 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 2.7 -1.0 0.4 1.7 -0.6
Medication: Cholesterol lowering 0.3 0.4 1.6 0.0 1.2 0.3 -0.1
Depression (self-reported) 1.3 1.5 2.2 -1.5 -0.7 1.2 1.4
Medication: Lansoprazole 0.7 0.8 2.8 -0.2 -0.3 0.5 1.7
Prospective memory result 0.4 0.5 0.9 -0.4 -0.7 -0.9 0.6
Lung cancer (father) 1.0 1.2 3.3 -0.8 0.2 -1.8 -0.8
Illnesses of mother 0.5 0.6 1.5 -0.2 0.9 1.2 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.3 7.4 13.1 3.6 -2.9 -2.8 0.3
Pulse wave Arterial Stiffness index 0.9 1.0 1.8 -1.0 -0.8 -0.7 -1.4
Impedance of arm (left) 0.2 0.8 1.4 0.2 -1.2 -1.1 0.7
Arm fat mass (right) 0.7 3.0 3.8 -1.9 -1.9 -1.1 1.8
Trunk predicted mass 0.1 0.7 1.4 1.2 0.3 0.5 -0.9
Standing height 0.2 2.2 7.4 2.7 -0.2 0.3 -1.2
Length of working week for main job 0.1 0.2 0.3 -0.4 -0.4 0.5 0.2
Exposure to tobacco smoke at home 1.5 1.7 5.1 -2.3 0.9 0.7 0.5
Breastfed as a baby 0.2 0.3 0.7 0.5 -0.4 0.8 -0.3
Tense / ‘highly strung’ 0.8 1.3 2.5 -0.1 -1.6 -0.5 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 11.5 -3.4 -0.7 -0.2 0.3
Hair/balding pattern: Pattern 4 0.8 2.0 4.5 0.1 -1.7 -2.1 0.9
Birth weight of first child 0.2 0.3 0.5 -0.3 -0.6 -0.7 0.6
Peak expiratory flow (PEF) 3.1 7.2 10.9 2.3 -3.3 -3.2 1.5
Pulse wave reflection index 0.7 0.9 2.5 -0.4 -0.5 -1.6 -0.9
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 -1.5 -0.5 1.0 1.2
Loud music exposure frequency 0.2 0.2 0.5 0.3 0.7 -0.4 0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.7 -0.8 -0.3 -0.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.7 0.4 -0.6 -1.3 -0.4
Blood clot in the leg (DVT) 0.9 1.1 3.6 -1.9 -0.3 -0.2 0.9
Medication: Paracetamol 0.9 1.5 2.3 -0.7 -1.5 1.5 1.0
Headache pain in last month 0.4 0.7 1.2 -1.0 0.2 1.1 0.8
Medication for cholesterol, blood pressure or diabetes 0.8 1.2 4.3 0.8 -0.3 0.0 -2.1
Glaucoma (self-reported) 0.6 0.7 1.5 0.1 -1.1 -1.2 -0.1
Gout (self-reported) 0.1 0.1 0.2 -0.1 -0.2 -0.2 -0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.1 0.7 0.2 -0.0 1.1
Medication: Amlodipine 0.4 0.5 1.5 -0.2 -0.5 -1.2 0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.8 -1.4 0.8 1.2 -0.1
Birth weight 1.0 2.2 3.5 -0.0 1.6 1.6 -1.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.5 -1.6 0.7 -0.4 -0.6
High blood pressure (siblings) 0.6 0.8 2.1 -0.7 1.5 -0.9 0.0
Forced vital capacity (FVC), Best measure 0.9 3.5 11.8 3.4 -0.4 -0.6 -1.2
Body fat percentage 1.0 4.1 5.4 -2.3 -2.1 -1.6 2.0
Leg fat percentage (right) 1.2 4.4 6.0 -2.5 -2.2 -1.6 2.0
Arm fat-free mass (right) 0.1 0.4 1.0 -0.1 0.4 1.0 -0.6
Exposure to tobacco smoke outside home 0.6 0.8 1.4 -1.2 0.6 0.9 0.8
Comparative body size at age 10 0.1 0.2 0.4 -0.5 0.1 -0.0 0.6
Number of full brothers 0.8 1.0 2.1 -1.0 -0.8 -1.5 -0.5
Worry too long after embarrassment 0.5 0.9 1.9 -0.4 1.2 -0.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 8.3 -2.9 -0.7 0.4 -0.4
Wheeze or whistling in the chest in last year 2.4 4.3 9.0 -2.4 3.0 1.4 -0.6
Number of children fathered 0.2 0.2 0.4 0.6 -0.5 -0.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.4 -0.8 1.0 1.2 -0.2
Age at first live birth 1.2 2.1 4.3 1.7 2.1 0.4 -1.0
Pulse wave peak to peak time 1.0 1.1 1.4 1.1 1.0 0.9 1.2
Health satisfaction 2.1 2.7 7.3 -2.7 1.3 0.5 -1.2
Shortness of breath walking on level ground 0.8 1.0 1.2 -1.1 -0.8 1.0 -1.1
Qualifications: College or University degree 0.2 0.7 1.2 1.1 -0.7 -0.7 -0.8
Eye problems/disorders: None of the above 0.8 1.0 2.2 0.9 -0.2 -1.5 0.9
Mouth/teeth dental problems: Loose teeth 2.1 2.5 3.4 -1.9 1.7 -1.7 -1.0
Emphysema/chronic bronchitis 1.9 2.1 5.2 -0.9 2.3 1.1 -1.1
Medication for pain relief, constipation, heartburn 2.4 4.1 9.5 2.0 -1.5 -3.1 0.7
Neck or shoulder pain in last month 0.8 1.1 2.6 -1.2 1.6 0.5 0.0
Medication: Blood pressure 0.8 1.5 2.8 -1.7 0.5 0.6 1.6
Angina (self-reported) 1.8 2.3 3.5 -1.6 0.6 -1.7 1.9
Migraine (self-reported) 0.6 0.7 1.5 -0.4 1.1 1.2 -0.3
Medication: Ibuprofen 1.2 1.4 2.5 -1.5 -0.9 1.6 0.1
Medication: Allopurinol 0.2 0.2 0.5 -0.3 -0.3 -0.4 -0.7
Medication: Omeprazole 1.1 1.3 5.0 -2.2 0.0 0.2 0.6
Medication: Seretide 50 evohaler 1.0 1.2 3.2 -1.1 -0.5 -0.4 1.8
Mean time to correctly identify matches 0.9 1.8 4.8 2.2 1.5 0.6 0.0
Heart disease (mother) 0.9 1.1 2.9 -0.3 -1.7 0.0 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.6 -0.8 -0.4 0.5 -1.3
Whole body fat mass 0.6 2.7 3.5 -1.9 -1.9 -1.1 1.6
Leg fat mass (right) 0.9 3.5 4.8 -2.1 -2.2 -1.3 1.8
Arm predicted mass (right) 0.0 0.1 0.4 0.1 -0.0 0.6 -0.4
Pulse rate, automated reading 0.1 0.2 0.4 0.0 -0.7 -0.4 0.4
Alcohol intake frequency. 1.2 2.8 4.9 -1.6 -1.9 -0.5 2.2
Comparative height size at age 10 0.3 1.5 4.7 2.2 -0.8 -0.3 0.7
Number of full sisters 0.4 0.5 1.6 -1.2 0.3 -0.4 0.0
Suffer from ‘nerves’ 2.8 4.3 10.4 0.4 -3.2 -1.9 1.8
Overall health rating 1.7 3.7 14.9 -3.9 0.2 0.0 0.1
Chest pain or discomfort 0.8 1.1 3.2 -1.8 0.2 -0.8 -0.6
Had major operations 0.7 0.8 1.6 -1.2 -0.2 1.3 -0.5
Age at last live birth 1.5 2.1 5.1 1.6 2.3 0.3 -0.9
Family relationship satisfaction 0.6 0.7 1.2 -0.7 1.0 -0.6 -1.1
Leg pain on walking 0.1 0.2 0.3 -0.5 -0.2 0.5 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.7 -0.1 0.8 0.1 0.7
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.7 -1.6 -0.7 0.6 1.0
Illness, injury, bereavement, stress in last 2 years 3.4 4.2 6.0 2.4 -2.2 -1.9 1.6
Medication: Aspirin 0.8 1.0 1.9 -1.3 1.4 0.8 -0.1
Supplements: Vitamin C 2.1 2.5 9.8 -3.1 -0.1 0.0 -0.1
Knee pain experienced in last month 1.6 2.6 6.7 -1.8 -0.2 -0.5 -2.6
Hypertension (Self-reported) 0.0 0.1 0.2 -0.5 -0.0 0.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 1.9 5.6 -1.2 2.4 0.7 -0.5
Illnesses of father: Heart disease 0.4 0.5 1.3 -1.1 -0.4 -0.8 0.2
Illnesses of siblings: Diabetes 1.3 1.6 4.5 -0.0 -1.2 -0.6 2.1
Smoking status: Previous 2.4 3.6 8.5 -2.9 1.7 1.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.8 1.7 -0.2 0.0 -0.6
Whole body fat-free mass 0.1 0.3 0.5 0.7 -0.2 0.3 -0.7
Leg fat-free mass (right) 0.0 0.2 0.3 0.3 -0.5 0.3 -0.5
Arm fat percentage (left) 1.0 3.9 5.7 -2.3 -2.0 -0.9 2.4
Average weekly red wine intake 0.5 0.7 1.4 0.4 -0.3 -1.0 -1.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.2 0.1 -0.6 1.3 1.8
Mood swings 2.6 4.7 14.6 -3.8 -2.0 0.1 0.5
Loneliness, isolation 2.9 4.0 8.2 -2.9 -2.4 -0.6 1.3
Long-standing illness, disability or infirmity 2.1 3.1 8.9 -3.0 0.8 0.3 -1.7
Ever had bowel cancer screening 1.1 1.3 4.1 -2.0 0.1 -0.4 1.0
Diabetes diagnosed by doctor 1.1 1.8 5.2 -1.4 -0.1 -0.0 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 1.9 -1.4 1.3 1.2 0.0
Friendships satisfaction 0.7 0.8 3.0 -1.7 0.4 -0.3 0.2
Qualifications: nursing, teaching 0.3 0.4 1.2 -0.3 0.0 -0.6 1.1
Commuting to job workplace: Walk 0.7 0.8 2.4 1.5 -0.7 -0.5 -0.1
Eye problems/disorders: Cataract 1.8 2.1 4.2 -1.0 1.2 2.1 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 1.9 -1.0 -1.2 -1.1 1.4
Medication for cholesterol 0.3 0.4 0.9 0.5 0.9 -0.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.1 0.3 0.3 -0.1 0.1
Back pain experienced in last month 1.2 1.8 4.4 -2.1 -0.3 0.2 -1.6
Mineral and other dietary supplements 0.8 1.0 2.3 -1.5 1.1 0.3 0.7
Breast cancer (self-reported) 0.3 0.4 0.7 -0.8 0.3 0.9 -0.3
Asthma (self-reported) 1.8 3.6 7.3 -2.7 1.2 2.2 -0.8
Osteoporosis (self-reported) 0.7 0.9 3.5 -1.9 -0.3 0.1 0.2
Osteoarthritis (self-reported) 0.5 0.7 1.9 -0.3 -0.1 1.4 -0.9
Medication: Aspirin 0.8 1.0 1.6 -1.2 1.1 1.1 -0.2
Medication: Gliclazide 0.6 0.7 2.2 -1.5 0.3 0.3 -0.5
Illnesses of father: None of the above (group 1) 0.6 0.8 1.5 0.9 1.2 0.4 -0.8
Smoking status: Current 2.0 3.2 5.5 -2.3 2.3 0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 7.9 2.8 -2.7 -1.0 0.2
Whole body water mass 0.0 0.3 0.5 0.6 -0.2 0.3 -0.7
Leg predicted mass (right) 0.0 0.2 0.4 0.3 -0.5 0.2 -0.6
Arm fat mass (left) 0.6 2.5 3.5 -1.9 -1.7 -0.9 1.6
Number of self-reported non-cancer illnesses 1.1 2.0 7.2 -2.7 0.4 0.6 0.5
Average weekly champagne plus white wine intake 0.4 0.5 1.3 -0.7 1.1 0.1 -0.6
Miserableness 1.2 2.0 5.2 -2.3 -1.7 -0.2 0.3
Guilty feelings 0.5 0.8 1.3 -1.1 0.6 0.6 -1.1
Wears glasses or contact lenses 0.0 0.0 0.1 -0.3 -0.1 0.1 0.0
Ever taken oral contraceptive pill 2.2 2.5 9.1 -3.0 -0.3 -0.7 0.4
Hearing aid user 0.3 0.4 0.9 -0.1 -1.0 0.7 0.1
Mother’s age at death 0.2 0.2 0.3 -0.6 0.5 -0.3 -0.2
Financial situation satisfaction 0.7 0.9 2.0 -0.5 0.9 -1.4 -0.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.0 1.0 -0.7 0.0 0.5
Commuting to job workplace: Public transport 0.3 0.4 1.4 1.2 -0.4 0.0 0.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.3 -0.2 -1.1 -0.5 -0.6
Medication: Blood pressure 0.2 0.4 0.8 -0.9 -0.4 0.6 0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.9 -0.9 0.1 0.1 0.1
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.6 0.9 -1.2 -1.3 0.2
High cholesterol (Self-reported) 0.9 1.5 3.2 -1.3 1.1 1.8 -0.3
Medication: Bendroflumethiazide 0.4 0.7 1.7 -0.8 -0.3 0.5 1.3
Medication: Paracetamol 1.1 1.8 3.2 -1.3 -1.8 1.3 0.8
Medication: Lisinopril 0.5 0.6 1.5 -0.7 0.4 1.2 -0.4
Medication: Atorvastatin 0.4 0.5 1.5 -0.2 1.2 -0.1 -0.7
Illnesses of father: High blood pressure 0.6 0.8 2.5 0.1 1.6 0.7 -0.0
Alcohol drinker status: Never 0.5 0.6 1.7 -0.7 0.4 1.3 -0.4
Ever smoked 3.5 6.2 13.6 -3.7 2.9 1.7 0.1
Basal metabolic rate 0.0 0.1 0.3 0.2 -0.5 0.1 -0.3
Leg fat percentage (left) 1.1 3.8 6.2 -2.5 -1.8 -1.6 1.8
Arm fat-free mass (left) 0.0 0.1 0.2 0.0 -0.5 -0.1 0.1
Number of operations (self-reported) 4.9 7.2 22.2 -4.7 0.9 2.4 0.3
Average weekly beer plus cider intake 0.6 0.9 1.8 1.4 0.1 0.1 -1.3
Irritability 0.3 0.6 1.1 -1.0 0.3 0.4 -1.0
Risk taking 1.1 1.6 5.0 -2.2 -0.9 0.2 0.9
Ever had prostate specific antigen (PSA) test 1.0 1.1 3.0 -0.7 0.9 -1.7 0.4
Fractured/broken bones in last 5 years 0.6 0.7 1.8 -1.4 -0.3 0.9 -0.2
Age started oral contraceptive pill 1.2 1.5 2.9 0.6 1.0 1.4 -1.7
Diastolic blood pressure, automated reading 0.5 1.5 5.1 -0.7 0.4 2.3 -0.5
Ever depressed for a whole week 0.7 0.8 1.7 -1.3 0.5 0.3 -1.2
Unable to work because of sickness or disability 1.7 2.2 4.6 -2.1 -1.7 -1.0 0.6
Commuting to job workplace: Cycle 0.7 0.9 2.0 1.4 -0.9 -0.6 -0.5
Myopia 0.8 1.2 2.7 1.2 1.6 -0.1 -0.8
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.3 1.1 0.0 0.1 -0.3
Cholesterol lowering medication 1.0 1.5 2.9 -1.4 1.1 1.7 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 4.4 -2.1 0.5 0.7 0.9
Pain experienced in last month 1.4 2.4 5.0 2.2 -0.9 -1.1 1.6
Supplements: Calcium 0.3 0.3 1.1 -1.0 -0.3 -0.0 0.4
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 1.2 0.1 -0.2 0.2
Heart attack/myocardial infarction (self-reported) 1.9 2.4 7.0 -2.6 1.1 0.9 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.3 -1.8 -0.2 -0.2 1.3
Heart disease (siblings) 0.4 0.5 0.8 -0.9 0.2 -0.6 -0.8
Alcohol drinker status: Previous 2.5 2.8 7.6 -1.0 -1.5 -0.7 2.7
Pack years of smoking 0.6 0.9 1.5 -1.2 0.2 -1.1 -0.8
Impedance of whole body 0.2 0.9 1.9 0.4 -0.9 -1.4 0.7
Leg fat mass (left) 0.8 2.9 3.9 -1.9 -2.0 -1.3 1.6
Arm predicted mass (left) 0.0 0.0 0.1 0.0 -0.2 -0.1 -0.3