Hub : Genes

SETD7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.214	0.0850	9.0e-03	-0.013	NA	-0.013	NA	-0.012	9.8e-01	NA	9.3e-01	NA	8.7e-01
2	GTEx	Esophagus Muscularis	0.130	0.0500	5.8e-04	0.046	NA	-0.002	NA	0.019	8.3e-04	NA	4.6e-01	NA	2.2e-02
3	GTEx	Muscle Skeletal	0.264	0.0537	9.1e-09	0.133	NA	0.109	NA	0.127	5.7e-13	NA	7.6e-11	NA	2.1e-12
4	GTEx	Testis	0.165	0.0650	2.5e-03	0.006	NA	0.020	NA	0.014	1.7e-01	NA	4.2e-02	NA	7.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	3.7	-1.9	-0.4	0.3	0.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	-1.5	-0.8	-0.3	0.7
Depressed Affect (Nagel 2018)	2.3	4.9	12.2	-3.5	-2.6	-0.5	0.4
Depression (Nagel 2018)	2.6	3.9	14.8	-3.8	-0.2	0.9	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.0	1.3	-0.2	1.7	-0.9
Neuroticism (Nagel 2018)	0.7	1.6	3.9	-2.0	-1.5	0.1	0.0
Schizophrenia (2018)	0.3	0.5	1.1	-0.3	-0.7	-0.6	1.0
Schizophrenia vs Biploar Disorder	1.9	2.5	6.4	2.5	0.2	-0.5	-1.8
Worry (Nagel 2018)	0.6	1.2	3.2	0.4	-1.8	-0.6	1.0
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	-1.3	-1.1	-0.8	0.5
Alzheimer’s Disease (in father)	2.6	2.8	5.1	-0.7	-2.0	-1.2	2.3
Alzheimer’s Disease (including proxy)	2.1	3.0	6.3	-1.4	-2.5	-1.3	1.4
Crohns Disease (2017)	0.6	1.3	2.8	-1.7	-1.1	0.6	1.0
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	-0.9	-0.4	0.7	0.3
Ulcerative Colitis (UC)	0.2	0.5	0.8	-0.2	0.6	0.9	-0.8
Major Depression (MDD)	1.9	2.4	4.7	-2.2	1.3	1.8	0.2
Reaction Time	0.5	1.0	2.2	1.5	0.8	0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.5	-0.9	0.2	0.1
Breast Cancer	0.4	1.0	3.5	0.4	-1.9	-0.4	-0.3
Ovarian Cancer	1.6	2.1	7.2	0.0	-0.9	-0.4	2.7
Prostate Cancer	0.2	0.3	0.6	0.3	0.8	0.6	0.2
Age at First Birth	2.4	3.5	5.7	2.4	1.3	1.9	-1.7
Bipolar Disorder (2011)	1.4	1.3	3.7	-1.9	0.7	1.1	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	4.7	0.2	-2.2	-0.3	1.1
Coronary Artery Disease (CAD)	1.0	1.2	4.1	0.3	-2.0	-0.5	0.7
Crohns Disease (2012)	1.0	1.6	4.6	-2.2	-0.8	1.0	0.1
Mean Putamen Volume	0.4	0.5	1.1	-0.7	-0.5	-0.2	1.0
Fasting Glucose	1.0	1.2	2.5	1.1	-0.6	1.6	0.9
HbA1C	1.2	1.3	4.8	0.2	-0.5	2.2	0.1
HDL Cholesterol	0.6	1.0	2.8	-0.4	0.9	1.7	-0.2
LDL Cholesterol	0.3	0.5	1.4	0.4	0.4	1.2	-0.7
Lupus	0.5	0.7	1.4	0.4	-1.2	-0.7	0.9
Neuroticism (2016)	0.5	0.7	2.6	-1.6	0.1	-0.4	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.8	-0.6	-0.2	-0.4
Rheumatoid Arthritis	1.2	1.6	3.8	-0.8	-2.0	-1.4	-0.2
Schizophrenia (2014)	0.1	0.2	0.5	-0.7	-0.1	0.5	0.4
Triglycerides	0.2	0.3	0.5	-0.1	-0.6	-0.4	0.7
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.8	-0.4	-1.7	-0.0	-1.3
Ulcerative Colitis	0.4	0.6	1.2	0.6	0.1	1.0	-1.1
Blood Eosinophil Count	0.2	1.6	2.6	-1.6	1.5	1.1	-0.6
Blood Platelet Count	0.1	0.6	1.1	1.0	-0.1	0.5	1.0
Blood Red Count	0.1	0.9	2.3	0.7	-1.5	0.2	0.9
Blood White Count	0.4	2.6	6.2	-2.5	1.3	1.5	-0.5
Heel T-Score	0.3	2.3	7.8	0.5	2.8	0.4	-0.9
BMI	0.7	4.0	11.9	-3.4	-1.8	-0.3	1.0
Height	0.4	7.1	14.5	3.8	-2.7	-2.0	1.7
Waist Hip Ratio (WHR)	1.4	6.3	16.2	-1.4	2.6	0.5	-4.0
Systolic Blood Pressure	0.1	0.7	1.5	-0.5	-1.2	1.0	0.3
Smoking Status	3.1	7.3	23.1	-4.8	2.1	1.3	0.5
Allergy or Eczema	0.9	2.5	5.1	1.1	-2.3	-1.9	0.4
Cardiovascular Disease	0.1	0.4	1.7	-1.3	-0.2	-0.1	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.1	0.7	0.4	0.7
Respiratory disease	1.5	3.2	8.8	-3.0	1.4	1.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.0	-1.4	-0.3	-0.1	1.7
Lung FEV1/FVC ratio	5.9	29.9	51.0	0.9	-7.1	-6.9	4.5
Lung FVC	0.3	1.4	3.0	1.7	0.5	-0.2	-1.5
Neuroticism	0.3	0.8	2.3	-1.5	-0.7	-0.0	-0.4
Chronotype (morning person)	0.9	2.1	5.5	1.5	-0.6	-0.5	2.3
Hair Pigment	0.0	1.4	2.2	-0.3	-1.5	-1.4	1.2
Tanning	0.0	0.1	0.1	0.1	0.3	-0.3	0.1
Hand grip strength (left)	0.5	1.4	3.6	0.9	-0.9	-1.9	0.6
Number of treatments/medications taken	1.3	2.3	4.9	-2.2	0.4	2.0	-0.1
Average weekly spirits intake	0.8	0.9	2.1	0.8	-0.8	1.5	0.6
Sensitivity / hurt feelings	0.2	0.3	1.0	-0.0	0.3	0.4	-1.0
Frequency of depressed mood in last 2 weeks	2.4	3.4	11.1	-3.3	0.1	0.3	1.5
Hearing difficulty/problems: Yes	2.2	3.4	6.1	0.4	2.5	1.7	-2.1
Relative age of first facial hair	0.7	1.4	3.3	0.8	1.8	0.8	-0.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	5.3	-1.8	-1.3	-2.3	0.3
Ever used hormone-replacement therapy (HRT)	1.4	1.7	3.3	-1.1	-1.3	-1.8	0.8
Ever had hysterectomy (womb removed)	1.5	1.7	2.5	-1.6	-1.4	1.5	-0.1
Systolic blood pressure, automated reading	0.1	0.4	0.9	-0.1	-0.6	0.9	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.5	0.2	-0.1	0.9
Angina	1.7	2.2	3.4	-1.5	0.6	-1.7	1.8
Medication for hormone replacement therapy	1.1	1.3	3.3	-0.7	-1.8	-1.0	0.4
Vitamin and mineral supplements	0.9	1.2	3.3	-0.4	0.8	1.8	-0.9
Supplements: Zinc	0.8	0.9	2.2	-1.5	0.9	-0.7	-0.4
Medication: Co-codamol	0.3	0.4	1.2	-1.1	-0.3	0.1	0.5
Medication: Metformin	0.7	1.0	1.7	-1.3	0.8	1.3	0.4
Diabetes (father)	1.9	2.3	4.9	1.4	-1.5	-0.3	2.2
Diabetes (mother)	0.9	1.1	3.3	0.2	-1.1	0.2	1.8
Severe depression (siblings)	0.7	0.8	2.0	-1.0	-0.0	1.4	0.4
Pack years adult smoking proportion	1.1	1.6	3.7	-1.9	0.1	-1.5	-0.8
Impedance of leg (right)	0.3	1.4	3.4	0.1	-1.2	-1.9	0.9
Leg fat-free mass (left)	0.0	0.2	0.8	0.1	-0.9	0.2	-0.3
Trunk fat percentage	1.0	4.0	4.7	-2.2	-2.1	-1.8	2.0
Hand grip strength (right)	0.4	1.0	2.2	1.5	-0.7	-1.2	0.2
Townsend deprivation index at recruitment	0.3	0.5	1.0	-0.8	0.2	1.0	-0.5
Current tobacco smoking	2.1	3.5	6.1	-2.5	2.3	0.9	-1.3
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.6	-0.2	0.1
Maternal smoking around birth	1.7	2.4	7.2	-2.7	1.5	0.1	0.4
Fed-up feelings	0.8	1.5	3.5	-1.9	-1.1	-1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	6.2	-2.5	-0.2	1.1	-0.2
Relative age voice broke	0.2	0.3	0.4	0.4	0.5	0.6	-0.5
Taking other prescription medications	1.6	2.4	7.1	-2.7	1.3	0.9	-0.4
Age when periods started (menarche)	0.1	0.2	0.6	-0.8	0.2	0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.8	-1.7	-1.4	1.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	1.2	0.8	-0.5	-0.2
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	6.7	-2.6	1.2	1.7	-1.1
Qualifications: CSEs or equivalent	0.8	1.1	2.1	-1.5	1.0	1.0	-0.5
Serious illness, injury or assault to yourself	2.1	2.5	9.7	-3.1	-0.3	-0.4	0.3
High blood pressure	0.1	0.3	0.9	-1.0	-0.3	0.3	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	1.1	-1.4	-0.8	-0.7
Multivitamins +/- minerals	1.5	1.9	3.2	1.8	-0.9	-1.7	0.7
Stomach or abdominal pain in last month	1.7	2.1	5.0	-2.2	-0.4	-1.7	0.5
Supplements: Glucosamine	0.5	0.6	1.5	0.3	-0.6	0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	6.2	0.2	-1.0	-0.2	2.5
Medication: Atenolol	1.1	1.4	3.4	-1.3	0.5	0.4	1.8
Medication: Levothyroxine sodium	0.4	0.7	1.9	1.4	0.6	0.8	-0.2
Sitting height	0.1	0.4	1.1	1.1	-0.6	0.2	-0.4
Chronic bronchitis/emphysema (father)	1.9	2.2	3.9	-2.0	1.6	0.9	-1.3
High blood pressure (mother)	2.2	3.1	5.6	2.4	1.2	-0.4	-2.3
Body mass index (BMI)	0.6	2.7	6.2	-2.5	-1.4	-0.7	1.5
Impedance of leg (left)	0.2	1.1	3.8	-0.1	-0.4	-2.0	0.7
Leg predicted mass (left)	0.0	0.3	0.8	0.1	-0.9	0.2	-0.5
Trunk fat mass	0.7	2.9	3.8	-1.7	-2.0	-1.3	1.7
Waist circumference	0.2	0.8	2.6	-1.6	0.2	0.1	-0.8
Number of incorrect matches in round	1.0	1.6	2.2	1.3	1.3	1.5	-0.9
Past tobacco smoking	3.2	5.8	13.1	3.6	-2.6	-1.8	-0.5
Alcohol usually taken with meals	1.4	2.2	4.1	-1.6	-1.1	-2.0	1.1
Nervous feelings	0.7	1.2	1.9	1.3	-1.0	-0.6	1.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	9.1	-3.0	-1.5	-0.5	1.6
Hearing difficulty/problems with background noise	2.7	4.3	7.4	-0.6	2.7	1.9	-2.3
Hair/balding pattern: Pattern 2	0.9	1.1	2.8	-0.6	-1.1	0.2	1.7
Had menopause	0.4	0.5	1.5	-0.4	-0.1	0.7	-1.2
Had other major operations	4.3	5.2	17.1	-4.1	0.3	1.9	-0.5
Forced vital capacity (FVC)	0.6	2.3	7.8	2.8	-0.8	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.9	0.4	-0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	7.8	-2.8	0.8	1.7	-0.7
Qualifications: None of the above	0.1	0.2	0.5	-0.3	0.7	0.1	-0.4
Financial difficulties in last 2 years	2.5	3.4	12.1	-3.5	-0.1	1.1	0.4
Mouth/teeth dental problems	0.1	0.2	0.6	-0.1	-0.2	0.8	0.5
Heart attack	1.5	1.9	5.8	-2.4	0.9	0.6	-0.8
Allergy	0.2	0.5	1.7	0.5	-0.3	-0.4	1.3
Pain all over the body in last month	1.8	2.0	5.2	0.1	-1.6	0.4	2.3
Diabetes (self-reported)	0.6	0.9	3.4	-0.1	-0.4	0.2	1.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	0.1	-0.9	-0.8	-1.1
Medication: Ramipril	0.7	0.9	2.8	-0.1	0.6	1.7	-0.4
Medication: Simvastatin	0.5	0.8	1.7	-1.3	0.7	1.0	-0.2
Fluid intelligence score	0.5	1.0	2.8	1.7	-0.5	-0.0	-1.0
Illnesses of siblings	0.9	1.2	2.4	1.6	-0.1	1.4	-0.8
Neuroticism score	0.4	0.9	2.4	-1.6	-0.9	-0.4	0.2
Weight	0.2	1.1	1.9	-1.1	-1.4	-0.6	0.9
Impedance of arm (right)	0.4	2.1	3.9	0.5	-1.7	-2.0	1.0
Arm fat percentage (right)	1.0	4.0	5.4	-2.2	-2.0	-1.3	2.3
Trunk fat-free mass	0.1	0.6	1.4	1.2	0.3	0.5	-0.9
Hip circumference	0.4	1.7	3.6	-1.1	-1.9	-0.5	1.3
Time employed in main current job	0.6	0.7	1.4	1.2	0.3	-0.3	-1.0
Alcohol intake versus 10 years previously	6.7	10.1	13.7	-3.7	-2.8	-2.9	3.2
Father’s age at death	0.4	0.6	1.1	-0.1	1.0	-0.9	-0.6
Worrier / anxious feelings	0.2	0.4	0.6	-0.8	-0.6	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.3	-1.5	-0.9	0.5	0.2
Falls in the last year	0.3	0.4	1.3	-0.4	-1.2	-0.1	0.0
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.5	-0.1	0.1	-1.1
Number of live births	0.7	1.0	2.9	1.0	1.7	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	2.1	7.2	11.7	3.4	-2.9	-2.9	0.5
Pulse rate	0.1	0.3	0.8	0.2	0.3	0.9	-0.2
Happiness	1.1	1.3	3.8	-1.9	0.9	-0.0	-0.8
Noisy workplace	0.7	0.8	2.5	-0.2	0.9	-0.0	-1.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.7	0.7	-0.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.0	-0.5	1.7	-0.3	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	1.8	1.3	1.0	1.3	-0.6
Asthma	2.0	3.9	6.1	-2.5	1.7	2.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.7	-1.0	0.4	1.7	-0.6
Medication: Cholesterol lowering	0.3	0.4	1.6	0.0	1.2	0.3	-0.1
Depression (self-reported)	1.3	1.5	2.2	-1.5	-0.7	1.2	1.4
Medication: Lansoprazole	0.7	0.8	2.8	-0.2	-0.3	0.5	1.7
Prospective memory result	0.4	0.5	0.9	-0.4	-0.7	-0.9	0.6
Lung cancer (father)	1.0	1.2	3.3	-0.8	0.2	-1.8	-0.8
Illnesses of mother	0.5	0.6	1.5	-0.2	0.9	1.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.4	13.1	3.6	-2.9	-2.8	0.3
Pulse wave Arterial Stiffness index	0.9	1.0	1.8	-1.0	-0.8	-0.7	-1.4
Impedance of arm (left)	0.2	0.8	1.4	0.2	-1.2	-1.1	0.7
Arm fat mass (right)	0.7	3.0	3.8	-1.9	-1.9	-1.1	1.8
Trunk predicted mass	0.1	0.7	1.4	1.2	0.3	0.5	-0.9
Standing height	0.2	2.2	7.4	2.7	-0.2	0.3	-1.2
Length of working week for main job	0.1	0.2	0.3	-0.4	-0.4	0.5	0.2
Exposure to tobacco smoke at home	1.5	1.7	5.1	-2.3	0.9	0.7	0.5
Breastfed as a baby	0.2	0.3	0.7	0.5	-0.4	0.8	-0.3
Tense / ‘highly strung’	0.8	1.3	2.5	-0.1	-1.6	-0.5	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	11.5	-3.4	-0.7	-0.2	0.3
Hair/balding pattern: Pattern 4	0.8	2.0	4.5	0.1	-1.7	-2.1	0.9
Birth weight of first child	0.2	0.3	0.5	-0.3	-0.6	-0.7	0.6
Peak expiratory flow (PEF)	3.1	7.2	10.9	2.3	-3.3	-3.2	1.5
Pulse wave reflection index	0.7	0.9	2.5	-0.4	-0.5	-1.6	-0.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	-1.5	-0.5	1.0	1.2
Loud music exposure frequency	0.2	0.2	0.5	0.3	0.7	-0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.8	-0.3	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.7	0.4	-0.6	-1.3	-0.4
Blood clot in the leg (DVT)	0.9	1.1	3.6	-1.9	-0.3	-0.2	0.9
Medication: Paracetamol	0.9	1.5	2.3	-0.7	-1.5	1.5	1.0
Headache pain in last month	0.4	0.7	1.2	-1.0	0.2	1.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.2	4.3	0.8	-0.3	0.0	-2.1
Glaucoma (self-reported)	0.6	0.7	1.5	0.1	-1.1	-1.2	-0.1
Gout (self-reported)	0.1	0.1	0.2	-0.1	-0.2	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	0.7	0.2	-0.0	1.1
Medication: Amlodipine	0.4	0.5	1.5	-0.2	-0.5	-1.2	0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.8	-1.4	0.8	1.2	-0.1
Birth weight	1.0	2.2	3.5	-0.0	1.6	1.6	-1.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.5	-1.6	0.7	-0.4	-0.6
High blood pressure (siblings)	0.6	0.8	2.1	-0.7	1.5	-0.9	0.0
Forced vital capacity (FVC), Best measure	0.9	3.5	11.8	3.4	-0.4	-0.6	-1.2
Body fat percentage	1.0	4.1	5.4	-2.3	-2.1	-1.6	2.0
Leg fat percentage (right)	1.2	4.4	6.0	-2.5	-2.2	-1.6	2.0
Arm fat-free mass (right)	0.1	0.4	1.0	-0.1	0.4	1.0	-0.6
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-1.2	0.6	0.9	0.8
Comparative body size at age 10	0.1	0.2	0.4	-0.5	0.1	-0.0	0.6
Number of full brothers	0.8	1.0	2.1	-1.0	-0.8	-1.5	-0.5
Worry too long after embarrassment	0.5	0.9	1.9	-0.4	1.2	-0.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	8.3	-2.9	-0.7	0.4	-0.4
Wheeze or whistling in the chest in last year	2.4	4.3	9.0	-2.4	3.0	1.4	-0.6
Number of children fathered	0.2	0.2	0.4	0.6	-0.5	-0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-0.8	1.0	1.2	-0.2
Age at first live birth	1.2	2.1	4.3	1.7	2.1	0.4	-1.0
Pulse wave peak to peak time	1.0	1.1	1.4	1.1	1.0	0.9	1.2
Health satisfaction	2.1	2.7	7.3	-2.7	1.3	0.5	-1.2
Shortness of breath walking on level ground	0.8	1.0	1.2	-1.1	-0.8	1.0	-1.1
Qualifications: College or University degree	0.2	0.7	1.2	1.1	-0.7	-0.7	-0.8
Eye problems/disorders: None of the above	0.8	1.0	2.2	0.9	-0.2	-1.5	0.9
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.4	-1.9	1.7	-1.7	-1.0
Emphysema/chronic bronchitis	1.9	2.1	5.2	-0.9	2.3	1.1	-1.1
Medication for pain relief, constipation, heartburn	2.4	4.1	9.5	2.0	-1.5	-3.1	0.7
Neck or shoulder pain in last month	0.8	1.1	2.6	-1.2	1.6	0.5	0.0
Medication: Blood pressure	0.8	1.5	2.8	-1.7	0.5	0.6	1.6
Angina (self-reported)	1.8	2.3	3.5	-1.6	0.6	-1.7	1.9
Migraine (self-reported)	0.6	0.7	1.5	-0.4	1.1	1.2	-0.3
Medication: Ibuprofen	1.2	1.4	2.5	-1.5	-0.9	1.6	0.1
Medication: Allopurinol	0.2	0.2	0.5	-0.3	-0.3	-0.4	-0.7
Medication: Omeprazole	1.1	1.3	5.0	-2.2	0.0	0.2	0.6
Medication: Seretide 50 evohaler	1.0	1.2	3.2	-1.1	-0.5	-0.4	1.8
Mean time to correctly identify matches	0.9	1.8	4.8	2.2	1.5	0.6	0.0
Heart disease (mother)	0.9	1.1	2.9	-0.3	-1.7	0.0	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.8	-0.4	0.5	-1.3
Whole body fat mass	0.6	2.7	3.5	-1.9	-1.9	-1.1	1.6
Leg fat mass (right)	0.9	3.5	4.8	-2.1	-2.2	-1.3	1.8
Arm predicted mass (right)	0.0	0.1	0.4	0.1	-0.0	0.6	-0.4
Pulse rate, automated reading	0.1	0.2	0.4	0.0	-0.7	-0.4	0.4
Alcohol intake frequency.	1.2	2.8	4.9	-1.6	-1.9	-0.5	2.2
Comparative height size at age 10	0.3	1.5	4.7	2.2	-0.8	-0.3	0.7
Number of full sisters	0.4	0.5	1.6	-1.2	0.3	-0.4	0.0
Suffer from ‘nerves’	2.8	4.3	10.4	0.4	-3.2	-1.9	1.8
Overall health rating	1.7	3.7	14.9	-3.9	0.2	0.0	0.1
Chest pain or discomfort	0.8	1.1	3.2	-1.8	0.2	-0.8	-0.6
Had major operations	0.7	0.8	1.6	-1.2	-0.2	1.3	-0.5
Age at last live birth	1.5	2.1	5.1	1.6	2.3	0.3	-0.9
Family relationship satisfaction	0.6	0.7	1.2	-0.7	1.0	-0.6	-1.1
Leg pain on walking	0.1	0.2	0.3	-0.5	-0.2	0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.1	0.8	0.1	0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.7	-1.6	-0.7	0.6	1.0
Illness, injury, bereavement, stress in last 2 years	3.4	4.2	6.0	2.4	-2.2	-1.9	1.6
Medication: Aspirin	0.8	1.0	1.9	-1.3	1.4	0.8	-0.1
Supplements: Vitamin C	2.1	2.5	9.8	-3.1	-0.1	0.0	-0.1
Knee pain experienced in last month	1.6	2.6	6.7	-1.8	-0.2	-0.5	-2.6
Hypertension (Self-reported)	0.0	0.1	0.2	-0.5	-0.0	0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	5.6	-1.2	2.4	0.7	-0.5
Illnesses of father: Heart disease	0.4	0.5	1.3	-1.1	-0.4	-0.8	0.2
Illnesses of siblings: Diabetes	1.3	1.6	4.5	-0.0	-1.2	-0.6	2.1
Smoking status: Previous	2.4	3.6	8.5	-2.9	1.7	1.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.8	1.7	-0.2	0.0	-0.6
Whole body fat-free mass	0.1	0.3	0.5	0.7	-0.2	0.3	-0.7
Leg fat-free mass (right)	0.0	0.2	0.3	0.3	-0.5	0.3	-0.5
Arm fat percentage (left)	1.0	3.9	5.7	-2.3	-2.0	-0.9	2.4
Average weekly red wine intake	0.5	0.7	1.4	0.4	-0.3	-1.0	-1.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.2	0.1	-0.6	1.3	1.8
Mood swings	2.6	4.7	14.6	-3.8	-2.0	0.1	0.5
Loneliness, isolation	2.9	4.0	8.2	-2.9	-2.4	-0.6	1.3
Long-standing illness, disability or infirmity	2.1	3.1	8.9	-3.0	0.8	0.3	-1.7
Ever had bowel cancer screening	1.1	1.3	4.1	-2.0	0.1	-0.4	1.0
Diabetes diagnosed by doctor	1.1	1.8	5.2	-1.4	-0.1	-0.0	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.9	-1.4	1.3	1.2	0.0
Friendships satisfaction	0.7	0.8	3.0	-1.7	0.4	-0.3	0.2
Qualifications: nursing, teaching	0.3	0.4	1.2	-0.3	0.0	-0.6	1.1
Commuting to job workplace: Walk	0.7	0.8	2.4	1.5	-0.7	-0.5	-0.1
Eye problems/disorders: Cataract	1.8	2.1	4.2	-1.0	1.2	2.1	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.9	-1.0	-1.2	-1.1	1.4
Medication for cholesterol	0.3	0.4	0.9	0.5	0.9	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.3	0.3	-0.1	0.1
Back pain experienced in last month	1.2	1.8	4.4	-2.1	-0.3	0.2	-1.6
Mineral and other dietary supplements	0.8	1.0	2.3	-1.5	1.1	0.3	0.7
Breast cancer (self-reported)	0.3	0.4	0.7	-0.8	0.3	0.9	-0.3
Asthma (self-reported)	1.8	3.6	7.3	-2.7	1.2	2.2	-0.8
Osteoporosis (self-reported)	0.7	0.9	3.5	-1.9	-0.3	0.1	0.2
Osteoarthritis (self-reported)	0.5	0.7	1.9	-0.3	-0.1	1.4	-0.9
Medication: Aspirin	0.8	1.0	1.6	-1.2	1.1	1.1	-0.2
Medication: Gliclazide	0.6	0.7	2.2	-1.5	0.3	0.3	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.8	1.5	0.9	1.2	0.4	-0.8
Smoking status: Current	2.0	3.2	5.5	-2.3	2.3	0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	7.9	2.8	-2.7	-1.0	0.2
Whole body water mass	0.0	0.3	0.5	0.6	-0.2	0.3	-0.7
Leg predicted mass (right)	0.0	0.2	0.4	0.3	-0.5	0.2	-0.6
Arm fat mass (left)	0.6	2.5	3.5	-1.9	-1.7	-0.9	1.6
Number of self-reported non-cancer illnesses	1.1	2.0	7.2	-2.7	0.4	0.6	0.5
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-0.7	1.1	0.1	-0.6
Miserableness	1.2	2.0	5.2	-2.3	-1.7	-0.2	0.3
Guilty feelings	0.5	0.8	1.3	-1.1	0.6	0.6	-1.1
Wears glasses or contact lenses	0.0	0.0	0.1	-0.3	-0.1	0.1	0.0
Ever taken oral contraceptive pill	2.2	2.5	9.1	-3.0	-0.3	-0.7	0.4
Hearing aid user	0.3	0.4	0.9	-0.1	-1.0	0.7	0.1
Mother’s age at death	0.2	0.2	0.3	-0.6	0.5	-0.3	-0.2
Financial situation satisfaction	0.7	0.9	2.0	-0.5	0.9	-1.4	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	1.0	-0.7	0.0	0.5
Commuting to job workplace: Public transport	0.3	0.4	1.4	1.2	-0.4	0.0	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-0.2	-1.1	-0.5	-0.6
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.4	0.6	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.9	-0.9	0.1	0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.6	0.9	-1.2	-1.3	0.2
High cholesterol (Self-reported)	0.9	1.5	3.2	-1.3	1.1	1.8	-0.3
Medication: Bendroflumethiazide	0.4	0.7	1.7	-0.8	-0.3	0.5	1.3
Medication: Paracetamol	1.1	1.8	3.2	-1.3	-1.8	1.3	0.8
Medication: Lisinopril	0.5	0.6	1.5	-0.7	0.4	1.2	-0.4
Medication: Atorvastatin	0.4	0.5	1.5	-0.2	1.2	-0.1	-0.7
Illnesses of father: High blood pressure	0.6	0.8	2.5	0.1	1.6	0.7	-0.0
Alcohol drinker status: Never	0.5	0.6	1.7	-0.7	0.4	1.3	-0.4
Ever smoked	3.5	6.2	13.6	-3.7	2.9	1.7	0.1
Basal metabolic rate	0.0	0.1	0.3	0.2	-0.5	0.1	-0.3
Leg fat percentage (left)	1.1	3.8	6.2	-2.5	-1.8	-1.6	1.8
Arm fat-free mass (left)	0.0	0.1	0.2	0.0	-0.5	-0.1	0.1
Number of operations (self-reported)	4.9	7.2	22.2	-4.7	0.9	2.4	0.3
Average weekly beer plus cider intake	0.6	0.9	1.8	1.4	0.1	0.1	-1.3
Irritability	0.3	0.6	1.1	-1.0	0.3	0.4	-1.0
Risk taking	1.1	1.6	5.0	-2.2	-0.9	0.2	0.9
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.0	-0.7	0.9	-1.7	0.4
Fractured/broken bones in last 5 years	0.6	0.7	1.8	-1.4	-0.3	0.9	-0.2
Age started oral contraceptive pill	1.2	1.5	2.9	0.6	1.0	1.4	-1.7
Diastolic blood pressure, automated reading	0.5	1.5	5.1	-0.7	0.4	2.3	-0.5
Ever depressed for a whole week	0.7	0.8	1.7	-1.3	0.5	0.3	-1.2
Unable to work because of sickness or disability	1.7	2.2	4.6	-2.1	-1.7	-1.0	0.6
Commuting to job workplace: Cycle	0.7	0.9	2.0	1.4	-0.9	-0.6	-0.5
Myopia	0.8	1.2	2.7	1.2	1.6	-0.1	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	1.1	0.0	0.1	-0.3
Cholesterol lowering medication	1.0	1.5	2.9	-1.4	1.1	1.7	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	4.4	-2.1	0.5	0.7	0.9
Pain experienced in last month	1.4	2.4	5.0	2.2	-0.9	-1.1	1.6
Supplements: Calcium	0.3	0.3	1.1	-1.0	-0.3	-0.0	0.4
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	1.2	0.1	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	1.9	2.4	7.0	-2.6	1.1	0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.3	-1.8	-0.2	-0.2	1.3
Heart disease (siblings)	0.4	0.5	0.8	-0.9	0.2	-0.6	-0.8
Alcohol drinker status: Previous	2.5	2.8	7.6	-1.0	-1.5	-0.7	2.7
Pack years of smoking	0.6	0.9	1.5	-1.2	0.2	-1.1	-0.8
Impedance of whole body	0.2	0.9	1.9	0.4	-0.9	-1.4	0.7
Leg fat mass (left)	0.8	2.9	3.9	-1.9	-2.0	-1.3	1.6
Arm predicted mass (left)	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.3