Hub : Genes

RAB33B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1580	0.0380	6.0e-10	0.214	NA	0.197	NA	0.202	5.5e-16	NA	9.8e-15	NA	4.5e-15
2	GTEx	Esophagus Gastroesophageal Junction	0.2190	0.0870	1.9e-03	0.005	NA	0.015	NA	0.020	2.0e-01	NA	8.8e-02	NA	6.0e-02
3	GTEx	Esophagus Muscularis	0.2710	0.0600	5.3e-14	0.257	NA	0.275	NA	0.273	8.5e-16	NA	6.1e-17	NA	8.5e-17
4	YFS	Blood	0.0320	0.0090	2.3e-11	0.045	0.031	0.042	0.034	0.042	1.9e-14	2.1e-10	9.4e-14	2.3e-11	1.3e-13
5	TCGA	Bladder Urothelial Carcinoma	0.0330	0.0220	7.8e-03	0.010	0.010	0.006	NA	0.001	4.1e-02	4.2e-02	9.6e-02	NA	2.3e-01
6	TCGA	Breast Invasive Carcinoma	0.0155	0.0087	1.3e-04	0.019	0.019	0.019	NA	0.019	7.6e-05	5.6e-05	5.7e-05	NA	6.0e-05
7	TCGA	Colon Adenocarcinoma	0.0710	0.0330	1.2e-05	0.115	0.084	0.101	NA	0.107	3.6e-07	1.5e-05	1.9e-06	NA	9.9e-07
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0275	0.0169	1.2e-03	0.024	0.023	0.016	NA	0.027	9.8e-04	1.1e-03	5.1e-03	NA	4.2e-04
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0450	0.0280	3.7e-03	0.038	0.043	0.004	NA	0.030	3.1e-03	1.7e-03	1.8e-01	NA	7.8e-03
10	TCGA	Lung Adenocarcinoma	0.0250	0.0131	1.3e-04	0.028	0.026	0.011	NA	0.028	2.7e-04	4.3e-04	1.5e-02	NA	2.6e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0272	0.0155	3.4e-04	0.028	0.021	0.018	NA	0.022	3.2e-04	1.9e-03	3.7e-03	NA	1.4e-03
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0760	0.0360	3.0e-05	0.069	0.071	0.049	NA	0.059	2.0e-05	1.4e-05	2.9e-04	NA	7.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.0	0.1	0.2	0.2	-0.3	-0.2	0.1	0.4	0.2	0.1	-0.3	0.1	-0.0	0.0	0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.5	-0.6	-0.4	0.7	0.6	0.6	0.5	-0.2	0.4	0.3	0.3	0.4
Depressed Affect (Nagel 2018)	2.7	5.6	8.5	2.7	-2.6	-2.1	2.5	1.9	2.1	2.7	1.7	1.8	2.5	2.5	2.9
Depression (Nagel 2018)	0.0	0.1	0.4	0.0	-0.6	0.3	0.2	0.3	-0.1	0.1	-0.2	-0.2	-0.0	-0.3	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.1	0.5	-0.9	-0.3	-0.0	0.1	0.0	0.5	-0.6	-0.3	0.3	0.1	1.0
Neuroticism (Nagel 2018)	0.9	2.1	4.4	1.5	-1.3	-1.3	1.5	1.1	1.2	1.7	1.1	0.9	1.5	1.5	2.1
Schizophrenia (2018)	0.1	0.2	0.5	0.5	-0.4	-0.3	0.7	0.4	0.6	0.6	-0.1	0.4	0.4	0.4	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.3	0.2	0.1	-0.2	-0.0	-0.2	-0.4	0.0	0.1	-0.3	-0.4	-0.7
Worry (Nagel 2018)	1.3	2.6	3.5	1.7	-1.5	-1.5	1.5	1.6	1.5	1.7	1.5	1.6	1.7	1.9	1.7
Alzheimer’s Disease (in mother)	1.0	1.2	1.7	1.2	-1.3	-1.0	1.2	0.8	1.1	1.2	0.8	0.9	1.1	1.1	1.3
Alzheimer’s Disease (in father)	3.2	3.5	4.7	1.9	-1.3	-2.1	1.8	1.5	1.8	1.9	2.0	1.6	2.0	2.1	2.2
Alzheimer’s Disease (including proxy)	3.9	5.7	7.3	2.6	-2.2	-2.4	2.5	2.0	2.3	2.6	2.1	2.1	2.5	2.6	2.7
Crohns Disease (2017)	0.5	1.0	2.5	0.9	-1.1	-0.9	1.3	1.6	1.0	0.9	0.8	1.2	0.8	0.5	0.9
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.2	-0.2	-0.3	0.3	0.6	-0.1	0.1	-0.3	0.3	0.0	-0.1	0.4
Ulcerative Colitis (UC)	0.4	0.8	1.9	-0.7	0.9	0.7	-1.0	-0.8	-1.2	-0.8	-1.4	-0.8	-0.9	-0.8	-0.5
Major Depression (MDD)	1.2	1.5	3.7	-1.3	1.9	1.0	-0.9	-0.9	-1.0	-1.2	-1.2	-1.5	-1.2	-1.3	-0.5
Reaction Time	0.2	0.3	1.4	-0.6	1.2	0.3	-0.2	-0.2	-0.4	-0.6	0.1	-0.5	-0.5	-0.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.3	1.0	-1.8	-0.9	0.5	0.7	0.9	1.0	0.5	0.5	0.9	0.7	1.3
Breast Cancer	1.2	2.9	5.0	1.8	-1.8	-1.6	2.0	1.1	1.4	1.8	1.4	1.6	1.9	2.2	1.6
Ovarian Cancer	0.9	1.2	2.3	1.0	-0.5	-1.1	0.8	1.3	1.5	1.0	1.2	0.8	1.1	0.8	1.4
Prostate Cancer	0.6	0.8	1.2	-0.8	1.1	0.6	-1.1	-0.9	-0.7	-1.0	-0.8	-0.9	-0.9	-0.9	-0.7
Age at First Birth	1.6	2.3	3.3	-1.4	1.5	1.3	-1.4	-1.6	-1.7	-1.4	-1.8	-1.6	-1.5	-1.3	-1.4
Bipolar Disorder (2011)	0.8	0.7	1.8	-0.8	1.1	0.6	-0.5	-0.6	-0.9	-0.7	-1.3	-0.6	-0.9	-0.9	-0.8
Body Mass Index (BMI) (2010)	3.3	4.5	6.6	2.5	-1.9	-1.8	2.6	1.9	1.9	2.4	1.7	1.7	2.3	2.2	2.5
Coronary Artery Disease (CAD)	2.4	2.9	3.9	1.8	-2.0	-1.6	1.7	1.9	1.7	1.8	1.3	1.7	1.7	1.6	1.5
Crohns Disease (2012)	0.3	0.5	1.1	0.7	-1.0	-0.7	1.1	0.8	0.4	0.7	-0.2	0.6	0.5	0.3	1.0
Mean Putamen Volume	0.1	0.1	0.3	0.4	-0.6	-0.4	-0.1	0.1	0.1	0.3	-0.6	0.4	0.0	0.3	0.1
Fasting Glucose	0.3	0.4	1.1	0.5	-1.0	-0.5	0.8	0.8	0.5	0.4	-0.1	0.0	0.3	0.1	1.0
HbA1C	0.2	0.2	0.7	0.6	-0.2	-0.3	-0.2	0.4	-0.1	0.4	-0.4	0.1	0.2	0.5	0.8
HDL Cholesterol	0.6	1.0	1.6	-1.1	0.9	1.0	-0.6	-0.8	-1.0	-1.0	-1.1	-1.1	-1.0	-1.3	-0.8
LDL Cholesterol	0.1	0.1	0.2	-0.3	0.5	-0.0	-0.4	0.2	-0.3	-0.3	-0.2	-0.2	-0.3	-0.3	0.2
Lupus	0.9	1.3	1.9	1.2	-0.7	-1.3	1.2	1.4	1.2	1.1	1.4	1.0	1.3	0.9	1.1
Neuroticism (2016)	0.2	0.2	1.6	0.0	1.3	-0.5	0.2	0.5	0.3	0.3	0.4	0.2	0.1	-0.2	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.7	-0.5	-0.9	0.7	0.5	0.6	0.7	0.4	0.3	0.6	0.6	0.7
Rheumatoid Arthritis	2.5	3.4	5.2	1.9	-1.6	-1.9	1.9	2.3	1.9	1.8	1.8	2.3	1.8	1.5	1.4
Schizophrenia (2014)	0.1	0.2	0.8	-0.2	0.7	0.1	-0.1	-0.4	-0.2	-0.2	-0.9	-0.4	-0.4	-0.3	-0.2
Triglycerides	0.2	0.3	0.8	0.7	-0.5	-0.4	0.5	0.3	0.4	0.5	0.4	0.3	0.5	0.8	0.9
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.5	1.9	-1.9	-1.6	1.6	1.5	1.1	1.8	0.3	1.3	1.4	1.5	1.8
Ulcerative Colitis	0.1	0.2	0.6	-0.0	0.4	0.1	-0.2	-0.5	-0.6	-0.2	-0.8	-0.7	-0.3	-0.3	0.6
Blood Eosinophil Count	0.3	2.0	3.0	-1.5	1.3	1.4	-1.0	-1.6	-1.6	-1.5	-1.3	-1.7	-1.5	-1.5	-1.0
Blood Platelet Count	0.0	0.1	0.2	-0.3	0.5	-0.4	-0.5	0.3	0.2	-0.2	-0.1	0.0	-0.3	-0.4	-0.2
Blood Red Count	0.3	2.9	6.5	1.6	-1.4	-1.9	1.6	1.9	1.7	1.6	1.5	1.1	1.5	1.5	2.5
Blood White Count	0.4	3.3	5.2	-1.9	1.5	2.0	-1.7	-1.1	-1.6	-1.8	-2.3	-1.5	-2.0	-1.9	-2.1
Heel T-Score	1.0	8.3	11.8	-2.9	3.4	3.0	-2.9	-3.0	-2.9	-2.8	-2.3	-2.3	-2.8	-2.5	-3.4
BMI	0.6	3.3	6.9	1.8	-1.6	-2.0	2.6	1.8	1.7	1.8	0.8	1.7	1.6	1.7	2.1
Height	0.6	11.4	16.2	3.5	-3.2	-4.0	3.3	3.3	3.3	3.1	3.7	2.7	3.4	2.8	4.0
Waist Hip Ratio (WHR)	1.2	5.3	8.2	-2.6	1.8	2.4	-2.2	-2.3	-2.4	-2.6	-1.5	-2.0	-2.3	-2.3	-2.9
Systolic Blood Pressure	0.3	1.5	4.9	1.3	-0.9	-1.5	1.0	1.5	1.1	1.1	0.4	0.8	0.9	0.9	2.2
Smoking Status	2.2	5.3	7.5	-2.1	2.3	2.2	-1.8	-2.6	-2.4	-2.2	-2.7	-2.5	-2.4	-2.0	-2.2
Allergy or Eczema	2.2	5.8	7.8	2.2	-2.5	-2.2	2.6	2.0	2.3	2.4	2.8	2.3	2.5	2.7	2.0
Cardiovascular Disease	0.0	0.2	0.6	0.3	-0.1	-0.7	0.2	0.5	0.2	0.4	-0.0	0.4	0.2	0.0	0.8
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.7	0.7	1.0	-0.5	-0.9	-0.7	-0.6	-0.8	-0.7	-0.7	-0.5	-0.7
Respiratory disease	0.9	2.0	3.0	-1.6	1.7	1.5	-1.0	-1.2	-1.5	-1.5	-1.0	-1.4	-1.4	-1.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.2	-0.2	-0.1	0.5	0.1	0.3	0.2	0.1	-0.0	0.1	0.2	0.5
Lung FEV1/FVC ratio	10.9	55.2	64.3	7.4	-7.4	-7.5	7.8	6.5	7.6	7.4	8.0	7.3	7.8	7.5	6.8
Lung FVC	0.1	0.3	1.8	-0.2	-0.2	0.7	-0.2	-1.4	-0.6	-0.2	-0.7	-0.8	-0.3	-0.0	-0.1
Neuroticism	0.2	0.4	0.8	0.7	-0.8	-0.4	0.9	0.5	0.3	0.8	0.3	0.5	0.7	0.7	0.8
Chronotype (morning person)	0.5	1.2	3.5	0.7	-0.4	-1.2	0.2	1.7	1.5	0.7	1.9	1.1	1.0	0.4	1.0
Hair Pigment	0.1	2.2	4.6	1.4	-1.2	-1.5	1.2	1.6	1.6	1.3	2.1	1.6	1.5	1.3	1.0
Tanning	0.0	0.4	1.8	-0.3	0.3	0.6	-0.6	-0.7	-0.6	-0.3	-1.3	-0.1	-0.6	-0.5	-0.9
Hand grip strength (left)	0.3	0.7	1.5	0.7	-0.8	-1.2	0.2	1.0	1.0	0.6	0.9	1.2	0.7	0.6	-0.0
Number of treatments/medications taken	0.2	0.3	0.7	-0.5	0.8	0.5	-0.1	-0.3	-0.8	-0.4	-0.8	-0.7	-0.5	-0.6	0.0
Average weekly spirits intake	0.3	0.4	1.1	0.8	-1.1	-0.6	0.7	0.6	0.2	0.6	-0.3	0.2	0.4	0.4	1.0
Sensitivity / hurt feelings	0.0	0.1	0.5	-0.1	0.4	-0.3	0.3	-0.1	0.0	0.1	0.3	-0.3	0.1	-0.1	0.7
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.3	-0.1	-0.4	0.1	0.0	0.4	0.1	0.0	-0.4	-0.1	-0.1	-0.6	0.0
Hearing difficulty/problems: Yes	3.9	6.0	8.8	-2.4	3.0	2.3	-2.3	-2.2	-2.5	-2.5	-2.4	-2.4	-2.6	-2.4	-2.3
Relative age of first facial hair	1.3	2.8	3.9	-1.9	1.4	1.6	-1.7	-1.4	-1.5	-1.9	-1.0	-1.7	-1.7	-2.0	-1.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.7	1.2	-0.9	-1.2	1.4	1.5	1.6	1.3	1.8	1.9	1.4	1.4	0.5
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.7	1.4	-0.6	-1.4	0.9	1.4	1.6	1.4	1.5	1.6	1.5	1.2	0.9
Ever had hysterectomy (womb removed)	1.6	1.8	3.5	1.5	-1.4	-1.3	1.2	1.5	1.3	1.5	0.7	1.0	1.3	1.3	1.9
Systolic blood pressure, automated reading	0.2	0.5	2.3	0.6	-0.5	-0.9	0.4	0.8	0.7	0.5	0.5	0.2	0.5	0.6	1.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.7	-0.0	0.0	-0.2	0.4	0.1	0.3	-0.0	0.9	-0.4	0.1	-0.2	0.7
Angina	0.4	0.5	1.5	-0.8	0.9	0.3	-1.0	0.2	0.1	-0.8	0.8	0.4	-0.4	-0.6	-1.2
Medication for hormone replacement therapy	3.2	3.6	4.8	2.0	-1.8	-1.9	1.5	1.8	1.9	2.0	1.8	1.9	2.0	2.0	2.2
Vitamin and mineral supplements	0.7	0.9	1.7	-0.8	0.9	1.1	-0.6	-0.8	-1.0	-0.8	-1.3	-1.3	-1.0	-1.0	-0.6
Supplements: Zinc	0.8	0.8	2.0	-1.0	0.9	1.1	-0.8	-1.2	-0.7	-0.9	-0.2	-0.6	-0.7	-0.6	-1.4
Medication: Co-codamol	0.1	0.1	0.2	0.3	0.0	-0.2	0.4	0.2	0.0	0.4	-0.5	0.3	0.2	0.1	0.0
Medication: Metformin	0.5	0.7	1.4	-0.8	1.1	0.9	-0.8	-0.6	-0.9	-0.8	-0.8	-1.2	-0.9	-0.9	-0.2
Diabetes (father)	2.0	2.5	4.1	1.6	-1.2	-1.8	1.2	2.0	1.8	1.5	1.3	1.6	1.5	1.3	1.8
Diabetes (mother)	0.5	0.7	1.1	1.0	-1.1	-0.7	0.6	0.8	0.8	1.0	0.1	0.6	0.8	1.0	1.1
Severe depression (siblings)	0.2	0.2	1.7	0.1	-0.1	0.3	0.0	-0.2	-0.4	0.2	-1.3	-0.2	-0.2	0.2	0.0
Pack years adult smoking proportion	0.0	0.1	0.3	0.1	-0.1	-0.2	0.3	0.0	0.1	0.1	0.6	0.4	0.3	0.1	-0.3
Impedance of leg (right)	0.5	2.3	4.2	1.4	-1.1	-1.5	1.3	1.6	1.8	1.5	2.0	1.3	1.7	1.3	1.6
Leg fat-free mass (left)	0.2	0.9	1.5	1.1	-1.2	-1.2	1.1	1.1	0.7	0.8	0.4	1.0	0.7	0.8	1.1
Trunk fat percentage	1.3	5.2	8.1	2.3	-2.0	-2.2	2.8	2.0	2.3	2.2	2.2	2.2	2.3	2.5	2.3
Hand grip strength (right)	0.1	0.2	0.5	0.5	-0.5	-0.5	0.2	0.5	0.6	0.4	0.4	0.7	0.4	0.3	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.8	-0.1	0.4	0.3	0.0	-0.1	-0.4	-0.2	-0.9	-0.3	-0.4	-0.3	0.2
Current tobacco smoking	3.1	5.0	7.4	-2.3	2.7	2.0	-2.0	-2.1	-2.4	-2.2	-2.2	-2.2	-2.3	-2.2	-2.1
Average weekly fortified wine intake	0.2	0.2	0.8	0.5	-0.9	-0.5	0.2	0.4	0.3	0.6	0.1	0.7	0.4	0.3	0.3
Maternal smoking around birth	0.9	1.2	2.1	-1.4	1.4	0.9	-1.5	-0.9	-0.9	-1.3	-0.5	-0.8	-1.1	-1.1	-1.2
Fed-up feelings	0.4	0.7	1.4	1.1	-0.9	-0.4	1.2	0.7	0.8	1.1	0.1	0.9	0.8	0.8	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.1	-0.3	0.5	0.2	0.3	-0.2	-0.1	-0.6	-0.2	-0.2	-0.4	-0.3
Relative age voice broke	0.1	0.2	0.9	-0.3	0.1	0.3	-0.3	-0.6	-0.3	-0.4	0.1	-1.0	-0.2	-0.6	0.3
Taking other prescription medications	0.9	1.4	3.3	-1.2	1.8	1.0	-0.6	-0.9	-1.3	-1.1	-1.2	-1.2	-1.2	-1.3	-1.1
Age when periods started (menarche)	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.4	-0.3	-0.0	-0.2	0.2	-0.3	-0.1	0.0	0.2
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.3	1.7	-1.3	-1.4	1.0	1.1	1.1	1.6	0.5	0.9	1.4	1.8	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.6	-0.8	0.3	1.2	-0.5	-1.1	-0.9	-0.7	-0.6	-0.6	-0.7	-0.6	-1.3
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	5.2	-1.2	0.5	1.3	-1.3	-1.9	-1.7	-1.2	-2.3	-1.9	-1.5	-1.1	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	1.0	-1.0	0.7	0.9	-0.5	-0.7	-0.6	-0.8	-0.5	-1.0	-0.8	-0.7	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.4	-0.1	-0.3	0.4	-0.0	-0.0	0.3	-0.2	0.2	0.2	0.4	0.3
High blood pressure	0.1	0.3	1.3	0.5	-0.4	-0.8	0.2	0.4	0.4	0.4	0.5	0.2	0.4	0.2	1.1
Hayfever, allergic rhinitis or eczema	1.0	2.1	2.7	1.4	-1.4	-1.4	1.5	1.3	1.3	1.5	1.6	1.3	1.6	1.5	1.5
Multivitamins +/- minerals	0.8	1.0	2.2	1.0	-1.1	-0.9	0.6	0.8	0.9	0.9	1.1	1.5	1.0	1.2	0.4
Stomach or abdominal pain in last month	0.2	0.2	0.7	0.3	-0.3	-0.1	0.2	0.3	0.5	0.4	0.8	0.8	0.5	0.6	-0.2
Supplements: Glucosamine	0.3	0.3	0.6	0.8	-0.8	-0.7	0.4	0.5	0.2	0.7	0.1	0.5	0.6	0.8	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	0.9	-0.5	-1.0	0.1	0.6	1.1	0.8	0.9	0.7	0.8	1.0	1.0
Medication: Atenolol	0.2	0.3	0.5	-0.6	0.6	0.6	-0.7	-0.5	-0.3	-0.7	0.0	-0.4	-0.5	-0.3	-0.5
Medication: Levothyroxine sodium	0.2	0.4	0.5	-0.6	0.7	0.7	-0.7	-0.5	-0.7	-0.6	-0.6	-0.4	-0.6	-0.7	-0.5
Sitting height	0.1	0.8	1.8	0.8	-0.8	-1.3	0.5	1.4	0.8	0.7	0.9	0.8	0.8	0.3	1.2
Chronic bronchitis/emphysema (father)	2.3	2.7	3.3	-1.7	1.7	1.6	-1.4	-1.7	-1.8	-1.8	-1.4	-1.6	-1.7	-1.4	-1.8
High blood pressure (mother)	0.8	1.1	2.1	-1.1	0.7	1.3	-1.1	-1.5	-1.2	-1.0	-0.5	-1.1	-0.9	-0.8	-1.1
Body mass index (BMI)	0.4	1.9	4.1	1.4	-1.1	-1.5	2.0	1.3	1.3	1.3	0.9	1.4	1.2	1.5	1.4
Impedance of leg (left)	0.2	0.8	2.8	0.7	-0.2	-0.8	0.6	0.8	1.1	0.7	1.7	0.8	1.0	0.6	0.7
Leg predicted mass (left)	0.2	0.9	1.5	1.1	-1.2	-1.1	1.1	1.1	0.7	0.8	0.4	1.0	0.7	0.8	1.1
Trunk fat mass	1.1	4.9	7.7	2.2	-1.9	-2.3	2.8	2.0	2.2	2.1	2.1	2.0	2.2	2.3	2.4
Waist circumference	0.0	0.1	0.4	0.1	-0.1	-0.2	0.6	0.1	-0.0	-0.1	0.2	0.1	0.0	0.1	0.3
Number of incorrect matches in round	0.9	1.5	2.6	-1.5	1.6	1.6	-1.0	-1.1	-1.1	-1.3	-0.6	-1.2	-1.1	-1.1	-1.3
Past tobacco smoking	3.9	7.1	10.5	2.5	-2.5	-2.4	2.3	3.2	2.7	2.5	3.2	2.9	2.8	2.3	2.4
Alcohol usually taken with meals	1.4	2.2	5.6	1.2	-1.4	-1.8	1.2	1.2	1.6	1.2	2.4	1.2	1.6	1.3	1.4
Nervous feelings	0.5	1.0	1.5	1.0	-1.0	-0.9	0.9	0.9	1.0	1.1	0.9	0.9	1.1	1.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.0	1.4	-2.2	-1.1	1.8	1.5	1.6	1.4	1.2	1.4	1.4	1.1	1.2
Hearing difficulty/problems with background noise	4.5	7.2	10.3	-2.8	3.2	2.5	-2.5	-2.2	-2.9	-2.9	-2.2	-2.3	-2.8	-2.7	-3.0
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	1.0	-0.7	-1.1	0.7	1.9	1.3	1.0	1.5	1.4	1.1	1.0	1.1
Had menopause	0.1	0.1	0.3	0.2	-0.1	-0.2	0.6	0.4	0.4	0.1	0.2	0.1	0.2	0.1	0.4
Had other major operations	0.1	0.2	0.5	-0.4	-0.0	0.7	-0.3	0.2	-0.6	-0.3	-0.3	-0.3	-0.3	-0.7	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.4	0.9	-1.2	-0.9	0.8	0.5	0.7	1.0	0.5	0.7	0.8	0.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-0.4	-0.1	1.1	-0.0	-1.1	-0.7	-0.3	-0.8	-0.6	-0.5	-0.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.3	-1.0	0.7	0.8	-1.1	-0.4	-0.9	-0.9	-1.1	-0.9	-1.0	-1.1	-0.6
Qualifications: None of the above	0.2	0.4	0.8	-0.7	0.8	0.9	-0.4	-0.1	-0.5	-0.7	-0.5	-0.5	-0.7	-0.8	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.5	0.0	-0.7	-0.0	0.1	0.5	0.1	0.1	-0.1	0.1	0.0	-0.3	0.2
Mouth/teeth dental problems	0.0	0.1	0.3	0.1	-0.0	-0.5	0.5	0.4	-0.1	0.1	-0.0	0.2	0.1	0.1	0.2
Heart attack	0.6	0.7	1.3	-1.0	0.9	0.8	-0.9	-0.3	-1.0	-1.0	-0.6	-0.6	-0.9	-1.1	-0.8
Allergy	0.0	0.1	0.2	0.4	-0.3	-0.4	0.1	0.3	0.4	0.3	-0.3	0.3	0.1	0.2	0.3
Pain all over the body in last month	2.4	2.6	4.1	1.7	-1.4	-1.6	1.9	1.8	1.5	1.6	1.2	1.3	1.5	1.5	2.0
Diabetes (self-reported)	0.2	0.3	0.6	0.4	-0.2	-0.4	0.6	0.7	0.6	0.4	0.7	0.3	0.4	0.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.8	-0.7	-0.5	0.8	0.5	0.5	0.9	0.4	0.8	0.8	0.9	0.4
Medication: Ramipril	0.4	0.5	1.4	-0.5	0.6	0.6	-0.3	-0.6	-0.6	-0.5	-1.2	-1.0	-0.7	-0.8	0.1
Medication: Simvastatin	0.5	0.7	1.3	-0.8	0.7	1.0	-0.6	-0.5	-1.1	-0.9	-1.0	-0.5	-0.9	-0.7	-1.0
Fluid intelligence score	0.2	0.5	2.3	0.7	-1.5	-0.3	0.3	0.3	0.4	0.7	0.4	0.0	0.7	0.5	1.0
Illnesses of siblings	0.1	0.1	0.5	0.1	-0.0	0.0	0.7	0.1	-0.1	0.2	-0.3	-0.3	0.0	0.1	0.3
Neuroticism score	0.4	0.9	1.9	1.1	-0.9	-0.9	1.2	0.7	0.7	1.1	0.6	0.6	1.0	0.9	1.4
Weight	0.5	2.6	4.4	1.7	-1.4	-1.8	2.1	1.7	1.5	1.4	1.4	1.5	1.5	1.5	1.8
Impedance of arm (right)	0.8	3.7	5.5	1.8	-2.1	-1.7	1.7	1.6	2.0	1.9	2.4	1.9	2.1	2.2	1.5
Arm fat percentage (right)	1.2	4.6	7.9	2.2	-2.0	-2.2	2.8	1.8	2.1	2.1	1.7	2.0	2.1	2.5	2.2
Trunk fat-free mass	0.0	0.1	0.3	0.0	0.1	-0.5	-0.1	0.4	-0.0	-0.3	-0.1	-0.0	-0.2	-0.5	0.3
Hip circumference	1.0	4.4	5.8	2.2	-2.0	-2.3	2.4	2.2	2.0	2.0	1.7	2.0	2.0	2.0	2.4
Time employed in main current job	0.2	0.2	0.7	-0.2	0.7	0.6	0.0	-0.9	-0.4	-0.2	-0.5	-0.6	-0.3	-0.2	-0.1
Alcohol intake versus 10 years previously	5.4	8.1	10.6	2.7	-2.7	-2.8	3.2	2.9	2.9	2.7	3.0	3.3	2.9	2.7	2.2
Father’s age at death	0.7	1.0	2.2	-1.0	0.3	1.0	-1.4	-1.5	-0.8	-0.9	-0.3	-0.6	-0.7	-0.6	-1.5
Worrier / anxious feelings	0.3	0.7	1.0	0.8	-0.5	-1.0	0.8	0.8	0.7	0.9	0.8	0.7	0.9	0.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.0	0.9	-1.0	-0.5	1.0	0.9	0.6	0.9	0.6	0.7	0.9	0.7	1.0
Falls in the last year	0.5	0.7	1.3	1.0	-1.1	-0.9	0.9	0.7	0.6	1.0	-0.5	0.8	0.6	1.1	0.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.6	0.1	0.7	-0.3	0.3	0.0	0.1	0.2	-0.2	-0.1	0.1	0.2	0.7
Number of live births	1.5	2.1	3.0	-1.5	1.0	1.5	-1.7	-1.7	-1.3	-1.6	-0.9	-1.5	-1.4	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1)	2.6	8.9	12.2	3.1	-3.5	-3.0	3.0	2.4	2.8	3.2	2.7	2.9	3.1	3.1	3.0
Pulse rate	0.2	0.3	0.6	-0.5	0.5	0.7	-0.8	-0.4	-0.5	-0.5	-0.5	-0.6	-0.6	-0.8	-0.5
Happiness	1.0	1.2	3.3	-0.8	0.5	0.9	-0.9	-1.4	-1.3	-0.8	-1.8	-1.1	-1.1	-1.0	-1.1
Noisy workplace	0.6	0.7	1.2	-0.8	0.6	0.9	-1.1	-0.9	-0.8	-0.8	-0.8	-0.9	-0.8	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.2	-0.9	0.5	0.8	-1.1	-1.1	-1.0	-0.9	-0.6	-0.5	-0.8	-0.9	-1.8
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	5.5	-1.9	1.6	1.8	-1.5	-2.3	-1.8	-1.8	-1.5	-1.9	-1.7	-1.7	-2.1
Mouth/teeth dental problems: Dentures	0.7	1.2	2.3	-1.0	0.6	1.3	-1.3	-1.1	-1.0	-0.9	-1.5	-1.2	-1.1	-0.9	-1.1
Asthma	1.3	2.5	3.4	-1.6	1.8	1.6	-1.3	-1.1	-1.8	-1.6	-1.5	-1.7	-1.6	-1.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-0.6	0.1	1.0	0.0	0.1	-0.6	-0.5	-0.8	-0.2	-0.6	-0.6	-0.5
Medication: Cholesterol lowering	0.8	1.3	1.9	-1.3	0.8	1.3	-1.0	-0.8	-1.1	-1.4	-0.8	-0.8	-1.3	-1.2	-1.4
Depression (self-reported)	0.3	0.4	0.8	0.6	-0.5	-0.7	0.3	0.6	0.5	0.7	0.5	0.2	0.7	0.7	0.9
Medication: Lansoprazole	0.1	0.1	0.4	0.3	-0.2	-0.6	0.2	0.4	0.3	0.3	0.2	0.4	0.3	0.4	0.6
Prospective memory result	0.3	0.3	1.2	0.5	0.1	-0.4	0.4	0.4	0.5	0.6	0.6	1.1	0.6	0.8	0.1
Lung cancer (father)	0.1	0.1	0.5	-0.1	-0.3	0.2	-0.1	-0.7	-0.4	-0.0	-0.5	0.2	-0.2	0.4	-0.7
Illnesses of mother	1.1	1.4	2.9	-1.1	1.7	1.1	-1.2	-0.4	-0.9	-1.2	-1.1	-0.7	-1.3	-1.5	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	11.6	3.1	-3.4	-2.7	2.9	2.5	2.8	3.0	2.6	3.0	3.0	2.9	2.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	0.9	-0.5	-0.8	1.1	1.1	0.7	0.9	0.5	1.1	0.9	0.6	1.0
Impedance of arm (left)	0.4	1.6	2.8	1.1	-1.5	-0.9	1.0	0.9	1.3	1.3	1.7	1.2	1.5	1.5	1.0
Arm fat mass (right)	1.0	4.1	6.9	2.1	-1.8	-2.2	2.6	1.8	2.0	1.9	1.7	1.9	1.9	2.2	2.1
Trunk predicted mass	0.0	0.1	0.2	0.0	0.1	-0.5	-0.0	0.4	-0.0	-0.3	-0.1	-0.0	-0.2	-0.5	0.3
Standing height	0.1	0.6	1.4	0.7	-0.7	-1.1	0.5	1.0	0.7	0.4	1.2	0.4	0.7	0.1	1.2
Length of working week for main job	0.1	0.1	0.4	0.3	0.1	-0.2	0.1	0.7	0.1	0.2	-0.2	0.5	0.1	-0.0	0.0
Exposure to tobacco smoke at home	0.9	1.0	2.4	-1.0	1.5	1.0	-1.0	-0.5	-0.7	-1.0	-1.0	-0.7	-1.0	-1.1	-0.8
Breastfed as a baby	0.2	0.2	0.8	0.5	-0.9	-0.3	0.5	-0.1	-0.0	0.4	-0.0	-0.3	0.4	0.3	0.9
Tense / ‘highly strung’	1.2	1.9	2.3	1.5	-1.5	-1.3	1.4	1.3	1.3	1.5	1.1	1.3	1.4	1.5	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.2	0.7	-1.0	-0.9	1.1	0.7	0.7	0.8	1.1	0.7	0.9	0.9	0.9
Hair/balding pattern: Pattern 4	1.1	2.6	3.3	1.6	-1.8	-1.6	1.8	1.8	1.8	1.6	1.6	1.7	1.6	1.5	1.1
Birth weight of first child	0.2	0.4	0.8	0.8	-0.5	-0.9	0.2	0.7	0.6	0.7	0.1	0.7	0.5	0.7	0.6
Peak expiratory flow (PEF)	4.6	10.6	15.7	3.5	-4.0	-3.0	2.9	2.9	3.1	3.5	2.8	3.4	3.4	3.4	2.9
Pulse wave reflection index	0.4	0.5	0.7	0.8	-0.7	-0.7	0.8	0.5	0.6	0.8	0.4	0.8	0.8	0.6	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.6	-0.4	-0.5	0.4	0.2	0.1	0.7	0.3	0.0	0.6	0.7	1.2
Loud music exposure frequency	0.5	0.6	0.8	-0.7	0.7	0.6	-0.9	-0.7	-0.8	-0.8	-0.7	-0.8	-0.8	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	-0.5	-0.4	0.4	-0.1	0.1	0.3	0.4	0.2	0.3	0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.4	-0.4	-0.3	0.5	0.6	0.7	0.5	0.7	0.7	0.6	0.3	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.5	0.1	-0.7	0.2	0.2	-0.1	0.2	0.1	0.2	-0.2	0.2	0.1	0.3
Medication: Paracetamol	0.9	1.5	3.6	1.4	-0.9	-0.9	1.0	1.3	1.0	1.5	0.9	0.8	1.3	1.4	1.9
Headache pain in last month	0.1	0.1	0.5	-0.3	0.6	0.6	-0.7	-0.0	-0.2	-0.2	0.1	-0.3	-0.1	-0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	0.1	-0.2	0.1	-0.0	-0.0	0.4	0.1	0.1	0.3	0.3	0.1
Glaucoma (self-reported)	0.8	1.0	1.4	1.2	-0.8	-1.0	0.7	0.8	0.8	1.2	1.0	1.0	1.1	1.1	1.1
Gout (self-reported)	0.1	0.2	0.7	0.3	-0.9	-0.1	0.7	0.6	0.3	0.4	-0.0	0.5	0.2	0.4	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.2	0.3	0.2	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	-0.2	-0.2	-0.1
Medication: Amlodipine	0.2	0.2	0.5	0.6	-0.7	-0.5	0.6	0.2	0.4	0.5	0.2	0.5	0.4	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.9	-0.8	1.4	0.6	-1.0	0.0	-0.6	-0.9	-0.3	-0.7	-0.7	-1.2	-0.5
Birth weight	0.9	2.0	3.6	-1.4	1.4	1.5	-1.1	-1.6	-1.6	-1.5	-1.0	-1.9	-1.3	-1.6	-0.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.3	0.3	0.1	-0.3	-0.1	-0.5	-0.4	-0.3	-0.0	-0.3	-0.5	-0.5
High blood pressure (siblings)	1.4	2.0	3.4	-1.3	1.5	1.1	-1.8	-1.5	-1.2	-1.5	-1.2	-1.2	-1.4	-1.5	-1.4
Forced vital capacity (FVC), Best measure	0.0	0.2	0.6	0.6	-0.8	-0.3	0.3	0.2	0.3	0.5	0.0	0.5	0.4	0.4	0.4
Body fat percentage	1.3	5.3	8.7	2.3	-1.9	-2.3	3.0	2.0	2.3	2.2	2.1	2.2	2.3	2.5	2.4
Leg fat percentage (right)	1.6	5.7	9.9	2.4	-2.0	-2.5	3.1	2.1	2.4	2.3	2.1	2.1	2.3	2.5	2.7
Arm fat-free mass (right)	0.0	0.1	0.4	-0.1	0.3	-0.2	-0.3	0.1	-0.4	-0.4	-0.6	-0.3	-0.5	-0.6	0.1
Exposure to tobacco smoke outside home	0.5	0.6	1.9	-0.5	0.7	0.3	-1.2	-0.7	-0.8	-0.6	-1.4	-0.9	-0.9	-0.8	-0.1
Comparative body size at age 10	0.0	0.1	0.3	-0.0	0.4	0.3	0.1	-0.5	-0.5	-0.1	-0.4	-0.3	-0.2	-0.1	-0.2
Number of full brothers	0.8	1.1	2.7	0.9	-1.0	-1.0	0.7	0.8	1.1	0.8	1.6	1.1	1.1	1.1	0.9
Worry too long after embarrassment	0.6	1.0	1.4	-1.0	1.2	0.7	-0.8	-1.0	-1.0	-1.0	-0.9	-1.0	-1.0	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	0.7	-1.5	-0.7	1.1	0.0	-0.1	0.7	-0.6	0.3	0.3	0.8	0.6
Wheeze or whistling in the chest in last year	4.4	7.9	9.9	-3.0	3.2	2.8	-2.9	-2.6	-2.7	-3.0	-2.2	-2.7	-2.9	-3.0	-2.7
Number of children fathered	0.1	0.2	0.7	0.4	-0.9	-0.2	0.5	-0.0	0.2	0.5	-0.3	0.1	0.3	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.1	-1.1	0.4	1.2	-0.6	-1.6	-1.4	-1.1	-1.8	-1.3	-1.3	-1.0	-1.3
Age at first live birth	2.2	3.9	4.6	-2.0	2.1	1.7	-2.1	-2.0	-2.1	-2.0	-1.7	-1.8	-1.9	-1.9	-2.1
Pulse wave peak to peak time	0.9	1.1	1.6	-1.1	0.7	1.0	-1.3	-1.2	-0.9	-1.1	-0.7	-1.3	-1.1	-0.8	-1.1
Health satisfaction	1.3	1.7	2.4	-1.2	1.3	1.6	-1.1	-1.5	-1.5	-1.1	-1.4	-1.2	-1.2	-1.1	-1.5
Shortness of breath walking on level ground	0.4	0.5	1.1	0.9	-1.0	-0.3	1.0	0.6	0.5	0.8	-0.1	0.2	0.6	0.8	0.9
Qualifications: College or University degree	0.1	0.2	0.6	0.8	-0.7	-0.7	0.6	-0.1	0.2	0.6	-0.1	0.3	0.5	0.4	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.6	0.1	-0.3	-0.3	-0.5	0.4	0.4	0.2	0.4	0.8	0.2	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.0	-1.6	1.7	1.7	-1.3	-1.6	-1.0	-1.4	-1.0	-1.3	-1.4	-1.5	-1.7
Emphysema/chronic bronchitis	4.1	4.6	5.9	-2.2	2.2	1.8	-2.4	-2.4	-2.2	-2.3	-1.7	-2.0	-2.1	-1.8	-2.4
Medication for pain relief, constipation, heartburn	1.6	2.7	4.1	1.7	-1.4	-1.8	1.2	1.3	2.0	1.6	2.0	1.6	1.8	1.6	1.3
Neck or shoulder pain in last month	2.2	3.2	4.6	-1.7	1.1	2.0	-1.9	-2.1	-1.8	-1.7	-2.0	-1.5	-1.8	-1.5	-2.1
Medication: Blood pressure	0.1	0.1	0.3	-0.4	0.3	0.1	-0.1	-0.5	-0.3	-0.5	-0.3	-0.5	-0.5	-0.4	0.2
Angina (self-reported)	0.4	0.5	1.4	-0.8	0.9	0.3	-1.1	0.2	0.1	-0.8	0.9	0.3	-0.4	-0.6	-1.2
Migraine (self-reported)	0.9	1.2	1.7	-1.1	1.1	1.0	-0.9	-1.1	-1.1	-1.1	-1.2	-1.3	-1.2	-1.0	-0.7
Medication: Ibuprofen	0.6	0.7	2.3	0.7	-1.5	-0.1	1.4	1.1	0.5	0.9	-0.1	0.8	0.6	0.6	0.7
Medication: Allopurinol	0.2	0.3	0.8	0.4	-0.6	-0.4	0.9	0.6	0.3	0.5	0.0	0.5	0.3	0.6	0.4
Medication: Omeprazole	0.0	0.1	0.1	0.2	-0.2	0.1	0.3	-0.4	-0.1	0.2	-0.1	-0.3	0.2	0.3	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.3	0.0	-0.5	0.4	0.6	0.3	0.3	0.3	0.5	0.3	0.2	0.1
Mean time to correctly identify matches	0.6	1.1	3.5	-1.2	1.9	0.8	-0.7	-1.1	-0.8	-1.2	-0.2	-1.1	-0.9	-1.1	-0.6
Heart disease (mother)	2.1	2.6	3.7	1.6	-1.8	-1.4	1.8	1.5	1.5	1.6	1.3	1.4	1.6	1.8	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.5	-0.6	-0.5	0.1	0.2	0.0	0.4	0.0	0.2	0.3	0.4	0.2
Whole body fat mass	1.0	4.2	7.1	2.1	-1.9	-2.1	2.7	1.8	1.9	1.9	1.7	1.8	2.0	2.2	2.3
Leg fat mass (right)	1.5	5.7	9.1	2.5	-2.1	-2.6	3.0	2.2	2.3	2.3	1.8	2.1	2.2	2.4	2.7
Arm predicted mass (right)	0.0	0.1	0.3	0.3	-0.2	-0.5	0.2	0.6	0.1	0.0	-0.0	0.1	0.0	-0.2	0.6
Pulse rate, automated reading	0.1	0.3	1.0	0.5	-0.4	-0.7	-0.2	1.0	0.7	0.4	0.5	0.9	0.4	0.4	0.2
Alcohol intake frequency.	1.8	4.3	6.2	1.9	-1.8	-1.9	2.2	2.5	2.0	1.9	2.2	2.1	2.0	1.9	2.2
Comparative height size at age 10	0.2	1.0	2.5	0.9	-0.4	-1.1	0.8	1.6	0.9	0.8	1.2	1.3	0.9	0.4	0.8
Number of full sisters	0.2	0.2	1.1	-0.4	0.5	0.3	-0.5	-0.3	-0.2	-0.4	-0.3	-0.2	-0.3	-0.2	-1.0
Suffer from ‘nerves’	6.0	9.5	10.6	3.2	-3.1	-3.3	3.0	3.1	3.0	3.1	2.7	3.1	3.1	3.2	3.0
Overall health rating	0.0	0.1	0.3	-0.1	0.3	0.2	0.2	-0.2	-0.5	-0.0	-0.4	-0.2	-0.1	0.1	-0.1
Chest pain or discomfort	0.1	0.1	0.4	-0.2	0.0	0.3	-0.0	-0.0	0.1	-0.2	0.6	0.1	0.0	-0.1	-0.5
Had major operations	0.1	0.1	0.2	0.3	-0.3	-0.5	0.2	0.4	-0.1	0.2	0.1	0.2	0.2	0.3	0.5
Age at last live birth	2.8	4.1	5.5	-2.2	2.4	2.0	-2.2	-2.0	-2.1	-2.1	-1.2	-2.0	-1.9	-2.0	-2.0
Family relationship satisfaction	0.8	1.0	2.1	-0.8	0.9	0.9	-0.5	-1.4	-1.0	-0.8	-1.4	-1.2	-1.1	-1.0	-0.7
Leg pain on walking	0.1	0.1	0.5	0.1	-0.5	0.3	-0.1	-0.3	-0.4	0.1	-0.7	-0.2	-0.1	0.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	-0.9	0.7	1.0	-0.9	-0.5	-0.8	-0.8	-0.7	-0.4	-0.8	-0.9	-1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.7	-0.8	-0.5	0.7	0.4	0.2	0.6	-0.8	0.1	0.2	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	3.9	4.8	5.7	2.2	-1.6	-2.4	2.0	2.2	2.4	2.1	2.2	2.3	2.2	2.3	2.2
Medication: Aspirin	0.9	1.1	2.1	-1.4	1.3	0.6	-1.0	-0.4	-1.0	-1.4	-0.4	-0.7	-1.2	-1.3	-1.2
Supplements: Vitamin C	0.0	0.0	0.0	0.1	0.2	-0.1	0.1	0.0	-0.1	0.0	-0.2	0.0	-0.0	-0.1	0.1
Knee pain experienced in last month	0.1	0.1	0.2	0.3	-0.1	-0.4	0.5	-0.0	-0.1	0.3	-0.2	0.4	0.2	0.5	0.1
Hypertension (Self-reported)	0.0	0.1	0.7	0.2	0.0	-0.6	0.0	0.3	0.2	0.1	0.6	0.1	0.2	-0.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.7	5.5	6.3	-2.4	2.4	2.3	-2.4	-2.5	-2.2	-2.5	-2.0	-2.5	-2.4	-2.5	-2.1
Illnesses of father: Heart disease	0.2	0.2	0.8	0.5	-0.9	-0.7	0.3	0.5	0.4	0.4	0.2	0.5	0.3	0.2	0.3
Illnesses of siblings: Diabetes	0.7	0.9	1.5	1.1	-1.2	-0.7	0.8	0.8	0.9	1.0	0.6	1.0	1.0	1.2	0.6
Smoking status: Previous	2.2	3.3	5.9	-1.6	1.4	1.7	-1.4	-2.3	-1.8	-1.6	-2.4	-2.2	-1.9	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.4	0.2	-0.2	-0.3	0.3	0.6	0.0	0.1	0.1	0.3	0.1	-0.3	0.3
Whole body fat-free mass	0.0	0.2	0.5	0.4	-0.4	-0.7	0.4	0.7	0.2	0.1	0.1	0.4	0.1	-0.0	0.5
Leg fat-free mass (right)	0.1	0.3	0.6	0.6	-0.8	-0.7	0.5	0.6	0.3	0.4	0.1	0.6	0.3	0.3	0.5
Arm fat percentage (left)	1.1	4.3	7.4	2.1	-1.9	-2.0	2.7	1.7	2.0	2.0	1.6	1.9	2.0	2.4	2.3
Average weekly red wine intake	0.1	0.1	0.3	0.2	-0.5	-0.1	0.2	-0.3	0.3	0.3	0.6	0.2	0.4	0.5	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.6	-0.0	-0.8	0.7	0.9	0.7	0.6	0.9	0.6	0.7	0.8	1.1
Mood swings	1.6	3.0	5.0	2.0	-2.2	-1.6	1.8	1.5	1.4	2.0	0.8	1.4	1.7	1.7	2.2
Loneliness, isolation	3.8	5.2	8.5	2.4	-2.1	-2.3	2.9	2.2	2.2	2.5	1.3	2.1	2.2	2.2	2.6
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-0.9	0.6	1.2	-0.6	-0.7	-1.1	-0.8	-0.6	-0.7	-0.8	-0.9	-1.1
Ever had bowel cancer screening	0.0	0.0	0.1	-0.1	0.0	-0.2	-0.1	-0.2	0.1	-0.1	0.4	-0.2	0.0	0.2	0.2
Diabetes diagnosed by doctor	0.0	0.0	0.2	0.1	0.1	0.0	0.3	0.2	0.3	0.0	0.1	-0.2	0.0	-0.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	3.7	-1.4	1.9	1.6	-1.8	-1.6	-1.6	-1.5	-1.6	-1.7	-1.6	-1.5	-1.7
Friendships satisfaction	0.1	0.2	0.5	-0.3	0.7	0.4	0.3	-0.5	-0.3	-0.2	-0.5	-0.4	-0.4	-0.1	-0.3
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.0	0.2	-0.4	0.4	-0.3	0.2	0.0	-0.2	0.2	0.0	0.1	-0.3
Commuting to job workplace: Walk	0.9	1.0	4.0	0.7	-0.8	-1.0	0.7	0.8	0.8	0.5	2.0	0.9	1.0	1.2	0.6
Eye problems/disorders: Cataract	1.2	1.4	2.5	-1.1	1.0	1.3	-0.9	-1.3	-1.3	-1.1	-1.5	-1.6	-1.2	-1.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	1.4	-1.4	-1.0	0.7	0.7	1.2	1.3	1.1	1.1	1.3	1.5	1.0
Medication for cholesterol	0.7	1.1	2.1	-1.0	0.2	1.2	-0.7	-1.4	-1.0	-0.9	-1.2	-1.1	-1.0	-0.9	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	-0.3	0.3	0.4	-0.6	-0.8	-0.5	-0.3	-1.0	-0.3	-0.6	-0.2	-0.6
Back pain experienced in last month	0.1	0.2	1.0	0.3	-0.1	-0.1	0.6	-0.3	-0.2	0.3	-1.0	0.1	-0.0	0.5	0.0
Mineral and other dietary supplements	1.0	1.3	1.6	-1.2	1.1	1.2	-0.9	-1.3	-0.9	-1.1	-1.2	-1.3	-1.2	-1.2	-1.1
Breast cancer (self-reported)	0.1	0.1	0.3	-0.2	0.5	0.2	-0.1	-0.4	-0.3	-0.2	-0.3	-0.5	-0.2	-0.2	-0.1
Asthma (self-reported)	0.7	1.4	2.0	-1.2	1.4	1.2	-0.8	-0.7	-1.4	-1.1	-1.3	-1.3	-1.2	-1.4	-0.8
Osteoporosis (self-reported)	0.3	0.3	0.9	0.4	0.3	-0.9	0.1	0.9	0.5	0.4	0.7	0.5	0.5	0.2	0.9
Osteoarthritis (self-reported)	0.1	0.1	0.5	0.1	0.5	-0.1	-0.2	0.7	-0.3	-0.1	-0.1	0.2	-0.1	-0.4	0.1
Medication: Aspirin	0.7	0.9	1.5	-1.2	1.2	0.5	-0.8	-0.3	-0.9	-1.2	-0.6	-0.7	-1.1	-1.1	-0.9
Medication: Gliclazide	0.2	0.2	0.5	-0.4	0.4	0.7	-0.7	-0.4	-0.4	-0.3	-0.5	-0.5	-0.4	-0.5	-0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	3.2	-1.2	1.2	1.5	-1.0	-1.8	-1.3	-1.2	-0.9	-1.5	-1.1	-0.8	-1.1
Smoking status: Current	3.4	5.4	8.2	-2.4	2.9	2.0	-2.1	-2.3	-2.5	-2.3	-2.2	-2.2	-2.4	-2.2	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	9.9	2.6	-3.1	-2.4	2.7	2.5	2.4	2.6	1.9	2.5	2.4	2.5	2.4
Whole body water mass	0.0	0.2	0.6	0.5	-0.4	-0.8	0.4	0.7	0.2	0.2	0.1	0.4	0.2	0.0	0.6
Leg predicted mass (right)	0.1	0.3	0.6	0.6	-0.8	-0.7	0.6	0.6	0.3	0.4	0.1	0.7	0.3	0.4	0.5
Arm fat mass (left)	0.8	3.4	5.8	1.9	-1.7	-1.9	2.4	1.6	1.7	1.7	1.4	1.7	1.7	2.0	2.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	-0.3	0.6	0.0	0.0	0.1	-0.4	-0.3	0.4	-0.1	-0.2	-0.3	-0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-0.8	0.7	0.5	-0.6	-1.3	-0.8	-0.8	-0.7	-1.3	-0.8	-0.9	-0.2
Miserableness	1.7	2.9	5.3	1.9	-1.9	-1.6	2.0	1.5	1.5	1.9	1.0	1.1	1.7	1.5	2.3
Guilty feelings	0.2	0.3	0.5	-0.7	0.4	0.7	-0.3	-0.5	-0.6	-0.5	-0.4	-0.7	-0.5	-0.7	-0.2
Wears glasses or contact lenses	0.1	0.1	0.3	-0.1	0.3	-0.5	-0.3	0.5	0.0	-0.1	0.3	0.4	0.0	0.1	-0.0
Ever taken oral contraceptive pill	0.1	0.1	0.4	0.0	-0.1	0.0	0.1	0.1	0.0	0.1	-0.2	0.6	0.1	0.2	-0.6
Hearing aid user	0.9	1.0	1.6	1.0	-0.7	-1.0	1.3	1.0	0.8	1.0	0.8	1.0	1.0	1.3	1.0
Mother’s age at death	0.2	0.3	1.0	-0.6	0.4	0.5	-0.5	-0.5	-0.3	-0.5	-0.1	-0.3	-0.4	-0.4	-1.0
Financial situation satisfaction	1.0	1.2	3.6	-1.1	0.7	1.4	-1.2	-0.9	-0.9	-1.0	-0.8	-0.4	-0.9	-1.2	-1.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.6	-0.0	-0.6	0.7	0.5	0.2	0.5	0.1	0.7	0.5	0.7	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.4	-0.5	0.1	0.0	0.3	0.4	0.4	0.3	0.5	0.4	0.4	0.0
Eye problems/disorders: Glaucoma	0.7	0.9	1.4	1.2	-0.9	-1.0	0.9	0.9	0.6	1.1	0.5	1.0	0.9	1.0	1.1
Medication: Blood pressure	0.2	0.3	0.9	0.4	0.1	-0.8	0.2	0.9	0.5	0.4	0.7	0.5	0.4	0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.2	0.2	0.3	0.0	-0.6	-0.7	-0.3	-0.7	-0.2	-0.4	-0.0	-0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.5	1.3	-1.0	-1.5	1.1	1.3	1.3	1.1	1.9	1.5	1.4	1.4	1.1
High cholesterol (Self-reported)	1.0	1.7	3.0	-1.3	0.6	1.5	-1.2	-0.9	-1.4	-1.4	-1.7	-1.2	-1.5	-1.4	-1.2
Medication: Bendroflumethiazide	0.1	0.1	0.8	0.3	0.3	-0.5	0.3	0.2	0.3	0.2	0.1	-0.2	0.1	0.1	0.9
Medication: Paracetamol	1.4	2.2	4.1	1.7	-1.2	-1.2	1.5	1.4	1.2	1.8	1.2	1.2	1.6	1.7	2.0
Medication: Lisinopril	0.1	0.2	0.5	-0.4	0.1	0.3	-0.7	-0.2	-0.5	-0.5	0.1	-0.5	-0.4	-0.5	0.2
Medication: Atorvastatin	0.9	1.1	2.0	-1.2	1.4	0.9	-0.7	-1.1	-0.9	-1.2	-0.6	-1.1	-1.1	-1.0	-1.2
Illnesses of father: High blood pressure	1.1	1.3	2.1	-1.3	1.3	0.9	-1.3	-0.9	-1.0	-1.3	-0.9	-1.2	-1.2	-1.4	-0.9
Alcohol drinker status: Never	0.1	0.2	0.6	-0.5	0.8	0.4	-0.2	0.0	-0.5	-0.4	-0.4	-0.2	-0.4	-0.5	-0.3
Ever smoked	4.6	8.1	10.9	-2.7	2.9	2.5	-2.5	-3.3	-2.9	-2.7	-3.2	-3.0	-2.9	-2.5	-2.8
Basal metabolic rate	0.1	0.5	1.1	0.8	-0.7	-1.1	0.8	1.0	0.6	0.5	0.5	0.7	0.5	0.4	0.9
Leg fat percentage (left)	1.1	4.0	7.7	2.0	-1.5	-2.0	2.8	1.7	2.0	1.9	1.9	1.8	1.9	2.1	2.2
Arm fat-free mass (left)	0.1	0.5	1.3	0.8	-0.5	-1.1	0.8	1.1	0.7	0.4	0.5	0.8	0.5	0.3	0.9
Number of operations (self-reported)	0.4	0.6	1.2	-0.8	0.6	0.7	-0.8	-0.5	-1.1	-0.9	-0.5	-1.1	-0.7	-0.9	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.2	0.5	0.2	-0.1	-0.1	-0.4	-0.3	-0.6	0.1	-0.3	-0.3	-0.7
Irritability	0.1	0.2	0.6	-0.3	0.1	0.7	-0.3	-0.5	-0.8	-0.3	-0.6	-0.5	-0.3	-0.3	-0.2
Risk taking	0.3	0.4	1.4	0.5	-1.2	-0.6	0.2	1.2	0.8	0.5	0.1	0.9	0.4	0.1	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.9	0.6	0.7	-0.4	-1.0	-0.6	-0.7	-0.3	-0.5	-0.6	-0.8	-1.0
Fractured/broken bones in last 5 years	0.3	0.4	1.7	0.5	-0.3	-1.0	0.7	0.7	0.3	0.5	-0.3	-0.0	0.3	0.2	1.3
Age started oral contraceptive pill	0.8	1.0	1.6	-1.0	0.9	0.9	-0.7	-1.2	-1.3	-1.0	-0.9	-1.1	-1.0	-0.6	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.4	0.5	0.4	-0.8	-0.5	-0.7	-0.6	-0.8	-0.9	-0.6	-0.4	0.4
Ever depressed for a whole week	0.3	0.4	1.1	-0.5	-0.1	0.3	-0.3	-0.7	-0.7	-0.4	-1.1	-0.7	-0.6	-0.6	-0.5
Unable to work because of sickness or disability	2.3	3.0	4.6	1.8	-1.9	-1.7	2.1	1.7	1.5	1.8	1.3	1.7	1.8	1.8	1.6
Commuting to job workplace: Cycle	0.6	0.7	1.9	0.8	-1.4	-0.8	0.5	0.7	0.8	0.9	0.8	0.6	0.8	0.6	0.9
Myopia	1.6	2.3	4.4	-1.6	1.4	2.1	-1.5	-1.7	-1.3	-1.5	-0.7	-1.5	-1.3	-1.5	-1.7
Vascular/heart problems diagnosed by doctor	0.1	0.1	0.4	-0.2	-0.0	0.7	0.2	-0.4	-0.3	-0.1	-0.6	-0.3	-0.2	-0.1	-0.7
Cholesterol lowering medication	1.1	1.6	3.2	-1.2	1.8	1.1	-1.3	-0.9	-1.4	-1.3	-1.2	-1.1	-1.3	-1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.4	0.3	0.4	-0.4	-0.7	-0.4	-0.4	-0.4	-0.7	-0.4	-0.3	-0.1
Pain experienced in last month	0.8	1.3	2.8	0.9	-0.9	-1.2	0.8	1.5	1.4	0.9	1.7	1.2	1.1	0.6	0.9
Supplements: Calcium	0.2	0.2	0.7	0.3	0.3	-0.3	0.3	0.5	0.5	0.3	0.9	0.3	0.5	0.2	0.6
Basal cell carcinoma (self-reported)	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1	0.1	-0.2	-0.1	-0.0	0.1	-0.1	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.0	-1.3	1.3	1.1	-1.2	-0.5	-1.2	-1.3	-0.8	-0.9	-1.2	-1.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.5	0.1	-0.7	0.2	-0.0	-0.1	0.2	0.1	0.2	-0.2	0.2	0.0	0.2
Heart disease (siblings)	0.1	0.2	0.7	-0.3	-0.0	0.4	-0.5	-0.3	-0.3	-0.4	-0.5	0.1	-0.4	-0.4	-0.8
Alcohol drinker status: Previous	2.9	3.3	5.1	1.5	-1.5	-2.0	1.6	2.0	1.9	1.6	2.3	1.5	1.8	1.7	2.2
Pack years of smoking	0.0	0.0	0.1	0.1	-0.1	-0.3	0.3	-0.0	0.1	0.1	0.4	0.2	0.2	0.1	-0.1
Impedance of whole body	0.3	1.3	3.0	1.0	-1.0	-0.9	0.8	0.9	1.3	1.2	1.7	1.0	1.4	1.2	1.1
Leg fat mass (left)	1.2	4.8	8.0	2.3	-1.9	-2.4	2.8	2.0	2.1	2.1	1.8	1.9	2.0	2.2	2.5
Arm predicted mass (left)	0.1	0.3	0.8	0.5	-0.3	-0.9	0.5	0.8	0.4	0.2	0.3	0.5	0.3	0.1	0.6