Hub : Genes

MOCS2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.3080 0.0980 1.1e-03 -0.006 NA 0.097 NA 0.026 5.7e-01 NA 4.7e-04 NA 4.9e-02
2 GTEx Esophagus Mucosa 0.1840 0.0510 2.4e-05 0.102 NA 0.063 NA 0.062 2.6e-07 NA 4.7e-05 NA 5.7e-05
3 GTEx Testis 0.1580 0.0640 4.8e-03 0.057 NA 0.004 NA 0.057 1.6e-03 NA 2.1e-01 NA 1.6e-03
4 METSIM Adipose 0.0417 0.0197 6.3e-03 0.011 0.010 0.014 0.013 0.010 6.3e-03 9.7e-03 3.2e-03 0.0036 8.6e-03
5 TCGA Bladder Urothelial Carcinoma 0.1570 0.0650 7.0e-04 0.003 0.028 0.036 NA 0.011 1.6e-01 1.9e-03 4.9e-04 NA 3.6e-02
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0375 0.0191 3.4e-03 0.027 0.022 0.011 NA 0.016 4.1e-04 1.6e-03 1.6e-02 NA 5.1e-03
7 TCGA Brain Lower Grade Glioma 0.0453 0.0243 2.6e-03 0.025 0.006 0.015 NA 0.012 6.3e-04 6.6e-02 7.1e-03 NA 1.4e-02
8 TCGA Prostate Adenocarcinoma 0.1553 0.0486 3.0e-09 0.050 0.077 0.064 NA 0.063 6.1e-06 1.9e-08 2.8e-07 NA 3.8e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.6 0.9 3.3 0.7 -0.9 1.1 0.4 -0.5 0.7 0.5 -1.8
Bipolar Disorder or Schizophrenia 0.6 1.4 5.7 -0.5 -1.6 1.1 -0.6 -1.0 2.4 -0.0 -0.5
Depressed Affect (Nagel 2018) 1.4 2.9 5.9 1.9 -1.2 -0.8 -0.4 -1.9 -1.5 -2.4 -2.4
Depression (Nagel 2018) 0.4 0.6 1.6 -0.6 -0.1 1.1 -0.1 1.3 0.1 -0.5 -1.1
Intelligence (Savage-Jansen 2018) 0.7 2.0 8.0 -1.5 2.8 0.6 0.5 1.4 -0.6 1.4 0.9
Neuroticism (Nagel 2018) 0.8 2.0 5.6 1.4 -0.2 -0.1 -1.3 -0.9 -1.8 -1.6 -2.4
Schizophrenia (2018) 0.7 1.5 6.0 -1.2 -1.3 0.5 -1.1 -0.9 2.4 -0.4 0.8
Schizophrenia vs Biploar Disorder 0.6 0.7 2.2 -1.0 -0.6 -0.5 -1.5 0.2 0.1 -1.2 0.8
Worry (Nagel 2018) 0.7 1.5 3.9 -0.0 -0.7 -0.6 -1.9 0.1 -1.7 -2.0 -0.9
Alzheimer’s Disease (in mother) 1.2 1.4 5.3 0.6 1.4 -0.9 -0.1 2.3 -1.3 -0.6 0.4
Alzheimer’s Disease (in father) 0.3 0.4 1.4 -0.1 0.3 -0.1 -0.2 -0.7 -0.9 -1.2 -0.1
Alzheimer’s Disease (including proxy) 1.2 1.7 4.0 0.1 1.4 -1.2 -0.2 2.0 -1.9 -1.4 0.8
Crohns Disease (2017) 0.1 0.3 0.9 -0.8 -0.4 -0.6 0.1 1.0 -0.7 -0.2 -0.1
Irritable Bowel Disease (IBD) 0.3 0.6 1.8 -1.4 -0.6 -0.2 1.1 -0.4 0.6 0.5 0.8
Ulcerative Colitis (UC) 0.6 1.0 2.7 -0.7 -0.3 0.7 1.6 -1.1 1.6 0.7 0.6
Major Depression (MDD) 0.4 0.5 1.6 0.5 -0.1 0.0 1.2 0.9 0.9 -0.8 0.0
Reaction Time 0.4 0.8 3.9 -0.3 0.9 -0.3 -0.4 2.0 -0.6 -0.8 0.8
Verbal and Numeric Reasoning (VNR) 0.8 2.0 6.7 -1.4 2.2 -0.5 -0.1 1.3 -2.6 0.1 0.5
Breast Cancer 0.8 2.0 3.1 -1.4 0.9 -1.7 -0.9 1.6 -0.5 -1.7 1.8
Ovarian Cancer 0.2 0.3 1.0 1.0 -0.1 0.5 -0.2 0.1 0.0 -0.9 -0.2
Prostate Cancer 0.4 0.5 3.5 -0.2 0.1 0.1 0.4 -0.3 -0.8 -1.9 -0.1
Age at First Birth 0.2 0.3 0.6 0.4 0.5 -0.2 0.4 0.6 0.5 0.6 0.8
Bipolar Disorder (2011) 0.6 0.6 2.1 1.4 0.7 -0.3 0.5 0.3 -0.5 0.5 -1.2
Body Mass Index (BMI) (2010) 0.5 0.7 2.7 0.1 -0.2 0.8 0.6 1.1 1.6 0.2 0.8
Coronary Artery Disease (CAD) 1.0 1.2 3.0 1.3 -0.4 1.1 1.7 -0.3 1.2 1.4 -0.0
Crohns Disease (2012) 0.6 0.9 2.4 -0.7 -1.4 1.0 -0.3 1.1 -0.1 -0.5 -1.6
Mean Putamen Volume 0.7 0.8 2.9 0.9 -0.1 -1.7 0.0 -0.8 -1.2 -0.9 0.1
Fasting Glucose 1.7 2.0 6.5 2.5 -0.1 -2.1 1.3 -1.3 -0.3 -1.3 0.4
HbA1C 1.5 1.7 5.7 -1.9 -0.7 -1.1 -1.1 0.9 -0.3 0.5 2.4
HDL Cholesterol 0.4 0.7 2.3 0.3 1.2 0.5 -0.8 -0.2 -0.7 1.5 -0.3
LDL Cholesterol 0.4 0.6 1.8 0.6 1.0 -0.7 0.6 1.4 -0.6 0.5 0.3
Lupus 1.2 1.9 9.3 0.3 -3.1 -0.8 -1.6 -0.4 -0.4 -1.4 -0.5
Neuroticism (2016) 2.4 3.4 8.5 2.4 -0.4 -0.6 -0.0 -1.8 -2.9 -1.4 -2.7
Primary Biliary Cirrhosis 0.5 0.8 1.9 -0.3 1.1 0.7 1.4 0.6 0.8 0.7 0.8
Rheumatoid Arthritis 0.7 1.0 3.6 -0.3 0.9 -0.7 1.1 -0.6 -1.9 -1.1 0.4
Schizophrenia (2014) 0.6 1.4 4.0 -1.1 -2.0 -0.2 -1.7 -0.9 1.4 -0.3 0.2
Triglycerides 0.7 1.2 5.4 -0.8 -0.5 -0.6 2.3 0.8 -0.1 -1.3 0.4
Type 2 Diabetes (T2D) (2012) 1.6 1.9 7.7 2.1 -1.1 0.6 0.8 0.1 2.8 -0.0 -0.8
Ulcerative Colitis 1.3 1.9 4.5 -1.6 -1.5 -0.2 1.2 -2.1 1.5 -0.6 1.2
Blood Eosinophil Count 0.2 1.6 6.6 -0.6 1.9 0.9 2.6 0.0 0.5 -1.0 -0.3
Blood Platelet Count 0.1 1.1 2.9 1.7 1.4 -0.4 -1.2 0.4 -0.8 0.5 -1.3
Blood Red Count 0.1 1.3 3.3 1.6 0.5 0.3 1.8 0.0 1.8 0.2 -0.9
Blood White Count 0.3 2.1 10.0 3.2 1.5 -1.2 -1.3 1.0 0.1 0.1 0.4
Heel T-Score 1.1 8.7 27.1 4.2 2.1 -5.2 1.5 -1.2 -3.7 -0.8 1.6
BMI 0.2 1.3 3.7 1.5 0.8 -1.4 1.9 -0.7 -0.7 0.8 0.5
Height 0.4 7.8 33.7 1.1 -1.4 -2.8 -2.1 -1.0 -5.8 -1.8 -3.1
Waist Hip Ratio (WHR) 0.2 0.8 2.0 1.4 1.3 -1.3 -0.3 -0.5 -0.1 0.3 0.4
Systolic Blood Pressure 1.0 5.1 10.0 1.9 2.4 2.3 3.2 0.4 2.4 3.1 -0.8
Smoking Status 0.7 1.6 4.6 1.2 1.6 0.2 1.6 -2.1 0.8 0.6 -0.7
Allergy or Eczema 0.7 1.9 4.6 1.8 -0.2 -0.9 0.1 -1.3 -2.1 -1.5 -1.6
Cardiovascular Disease 0.5 1.5 6.3 0.0 0.4 0.7 1.4 0.4 2.5 1.5 0.9
Hypothyroidism (self reported) 0.4 0.9 2.3 1.4 -0.4 -0.8 0.5 -0.6 -0.9 0.5 -1.5
Respiratory disease 1.0 2.3 6.7 0.7 -1.9 -0.9 -0.9 -2.1 -0.5 -1.1 -2.6
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.8 1.4 1.0 -1.1 1.7 0.0 0.4 0.1 0.2
Lung FEV1/FVC ratio 1.2 5.9 31.7 -1.2 1.9 1.6 5.6 1.0 1.2 1.8 1.6
Lung FVC 0.1 0.5 1.5 -0.5 0.9 0.1 0.4 1.2 -0.9 0.3 0.8
Neuroticism 1.4 3.4 8.8 1.6 -0.1 -0.9 -1.2 -1.2 -3.0 -2.5 -2.5
Chronotype (morning person) 0.2 0.4 0.9 0.9 1.0 0.6 -0.4 0.4 0.8 -0.1 -0.3
Hair Pigment 0.2 5.6 14.3 0.4 0.1 1.6 3.7 3.0 3.8 1.5 1.5
Tanning 0.0 0.5 1.7 -0.3 -1.0 0.0 0.3 -1.3 0.3 -0.9 -0.2
Hand grip strength (left) 0.3 0.8 3.3 -0.3 1.4 0.9 -0.5 -0.4 -1.8 -0.0 -0.2
Number of treatments/medications taken 0.4 0.6 1.6 0.1 -0.5 0.7 0.2 -1.2 1.1 0.8 -1.0
Average weekly spirits intake 1.5 1.8 4.9 0.9 -0.9 -2.2 0.0 -1.4 -2.0 -1.3 -0.9
Sensitivity / hurt feelings 0.3 0.6 1.1 -0.4 1.0 1.0 -0.9 0.4 -0.1 0.5 -0.9
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.0 -0.4 -1.0 0.8 0.7 -0.3 -1.0 -0.9 -1.7
Hearing difficulty/problems: Yes 0.6 1.0 4.1 -0.9 -2.0 0.7 -0.1 0.1 0.9 -0.8 -1.0
Relative age of first facial hair 0.5 1.1 3.9 1.0 2.0 -0.6 -0.8 -1.0 -1.2 0.2 -0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.9 1.6 -0.1 0.2 -0.5 -0.0 -0.1 -0.9 -1.7
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.7 1.0 -0.3 0.6 1.3 -1.2 0.3 0.6 -0.8
Ever had hysterectomy (womb removed) 0.9 1.0 3.7 -0.9 0.4 0.5 0.2 1.7 -0.1 1.9 0.4
Systolic blood pressure, automated reading 0.7 2.0 4.8 2.2 1.8 0.4 2.1 0.5 0.4 1.5 -0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.7 -1.3 0.1 -0.0 -0.6 1.3 0.4 -0.1 1.1
Angina 1.0 1.3 4.3 0.3 2.0 0.6 0.4 1.0 -0.2 2.1 0.2
Medication for hormone replacement therapy 1.2 1.3 4.7 -1.1 -1.3 2.2 0.8 -0.2 0.8 0.0 -1.2
Vitamin and mineral supplements 0.1 0.2 0.8 0.3 0.1 0.5 0.3 0.9 0.1 0.4 0.1
Supplements: Zinc 0.5 0.6 3.0 -1.0 0.2 0.1 0.1 -1.7 -0.8 0.3 0.1
Medication: Co-codamol 1.1 1.3 4.5 -0.2 0.8 2.1 0.7 1.7 0.9 0.6 -0.9
Medication: Metformin 0.6 0.9 2.9 -0.4 0.9 -0.5 1.0 1.0 0.9 0.4 1.7
Diabetes (father) 0.3 0.4 0.9 0.5 -0.2 0.9 0.9 0.5 -0.4 0.3 -0.9
Diabetes (mother) 0.3 0.3 1.3 -0.4 -0.5 0.2 0.2 -0.7 1.1 -0.6 -0.0
Severe depression (siblings) 0.3 0.4 1.5 0.4 -0.5 0.5 0.1 -0.5 0.1 -0.8 -1.2
Pack years adult smoking proportion 1.4 2.2 7.6 0.7 -0.6 -2.8 0.3 -1.2 -1.7 -2.1 0.5
Impedance of leg (right) 0.8 3.9 10.2 -0.9 0.9 3.2 1.2 0.8 2.8 2.3 -2.0
Leg fat-free mass (left) 0.5 2.5 12.9 1.1 0.0 -2.2 -0.2 -0.8 -3.6 -0.7 -0.3
Trunk fat percentage 0.4 1.7 5.1 2.2 1.0 -1.1 2.1 0.1 -1.2 0.1 -0.8
Hand grip strength (right) 0.4 1.1 3.8 0.5 1.3 0.6 -0.1 -1.2 -1.9 -0.3 -0.9
Townsend deprivation index at recruitment 0.1 0.2 0.6 -0.7 0.2 0.3 0.8 -0.4 0.4 0.0 0.2
Current tobacco smoking 0.6 0.9 5.4 0.5 2.3 0.1 0.6 -0.4 -0.8 0.3 0.4
Average weekly fortified wine intake 0.4 0.5 2.6 0.3 -0.2 -0.6 -0.3 -0.6 0.5 -1.6 0.5
Maternal smoking around birth 0.6 0.8 1.9 1.1 1.4 -0.7 0.3 -0.6 -0.6 -1.4 -0.4
Fed-up feelings 2.0 3.6 9.2 1.7 -2.5 0.3 -0.1 -2.1 -1.1 -2.1 -3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.9 -0.3 0.7 1.0 -0.7 1.4 -0.6 0.6 -0.6
Relative age voice broke 0.9 1.4 6.7 0.7 2.6 0.3 -1.2 0.9 -1.1 0.3 -0.4
Taking other prescription medications 0.7 1.1 3.2 0.5 -1.7 -0.9 -0.6 -0.8 0.6 -1.8 -0.6
Age when periods started (menarche) 0.5 1.3 3.6 -1.9 0.4 -0.1 -1.1 -1.6 -1.7 -0.2 -0.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -0.3 -0.1 0.7 0.8 0.8 1.1 0.5 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 5.8 1.8 0.5 -1.9 0.3 1.2 -2.4 -0.1 0.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 -0.4 0.4 0.9 -0.0 0.8 1.1 -0.3 0.4
Qualifications: CSEs or equivalent 0.5 0.7 2.9 -0.1 -0.9 0.5 0.6 0.6 0.2 -1.7 -0.9
Serious illness, injury or assault to yourself 0.7 0.9 2.7 1.6 -0.7 0.8 -0.6 0.3 0.5 0.0 -1.6
High blood pressure 0.5 1.5 6.1 0.8 0.7 0.8 2.5 -0.3 1.9 0.7 -0.3
Hayfever, allergic rhinitis or eczema 0.7 1.5 3.7 1.9 -0.2 -0.2 0.9 -1.1 -1.7 -0.9 -1.7
Multivitamins +/- minerals 0.2 0.2 0.8 0.1 -0.0 0.3 -0.0 -0.6 -0.6 -0.2 -0.9
Stomach or abdominal pain in last month 0.3 0.4 1.5 0.9 -0.5 -0.0 -1.2 0.8 -0.5 -0.0 -0.0
Supplements: Glucosamine 0.2 0.3 0.7 0.5 0.0 0.4 0.8 -0.8 0.5 0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.5 0.7 -0.4 -0.5 0.4 0.0 -0.1 -0.3 0.2
Medication: Atenolol 2.6 3.3 10.2 -1.1 1.2 1.5 0.1 3.2 2.2 1.9 1.5
Medication: Levothyroxine sodium 0.3 0.6 1.5 0.5 -1.2 0.3 0.6 -0.7 1.1 -0.1 -0.8
Sitting height 0.6 4.1 15.1 2.0 -0.4 -3.4 0.2 -0.7 -3.9 -1.0 -1.1
Chronic bronchitis/emphysema (father) 1.4 1.7 5.0 0.4 1.4 -0.5 -2.2 -0.7 0.5 2.2 0.5
High blood pressure (mother) 0.9 1.2 3.7 0.1 1.8 1.9 0.8 1.1 0.7 0.7 -0.1
Body mass index (BMI) 0.3 1.3 4.5 2.1 0.3 -0.6 1.5 -0.9 -1.3 0.6 -0.8
Impedance of leg (left) 0.6 3.0 7.5 -0.3 1.0 2.7 1.1 1.2 2.3 2.0 -1.9
Leg predicted mass (left) 0.5 2.4 12.2 1.0 -0.1 -2.2 -0.1 -0.9 -3.5 -0.8 -0.3
Trunk fat mass 0.5 2.0 4.8 2.2 0.9 -1.5 1.8 -0.1 -2.0 0.1 -1.0
Waist circumference 0.4 1.5 4.2 2.0 1.2 -1.2 1.3 -0.3 -1.3 1.4 -0.1
Number of incorrect matches in round 0.5 0.8 3.0 -0.7 -0.0 1.2 1.0 0.7 1.7 -0.0 0.1
Past tobacco smoking 0.9 1.7 5.9 -1.4 0.7 0.5 -0.5 2.0 -2.4 0.1 0.3
Alcohol usually taken with meals 2.0 3.3 10.1 -1.0 -1.9 -1.3 -3.2 -1.5 -2.4 -1.2 -0.6
Nervous feelings 0.7 1.2 3.9 1.1 -0.4 0.2 -1.1 -0.1 -2.0 -1.1 -1.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.0 1.0 -1.5 0.3 -0.8 -0.8 -1.6 -0.9 -2.2
Hearing difficulty/problems with background noise 1.1 1.8 4.3 -0.8 -0.1 1.9 1.1 0.2 2.1 -1.6 -1.5
Hair/balding pattern: Pattern 2 0.3 0.4 1.7 0.8 1.0 0.2 0.3 -0.4 -0.1 1.3 -0.1
Had menopause 1.0 1.3 3.8 1.6 -0.8 -1.0 -0.2 -0.7 -1.9 -1.0 -1.0
Had other major operations 0.5 0.6 1.3 0.3 0.8 -0.9 -0.8 1.0 -1.1 -0.3 -0.1
Forced vital capacity (FVC) 0.1 0.5 2.2 0.3 0.0 0.1 0.6 0.2 -1.5 -0.2 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.7 2.4 0.7 -1.9 0.9 0.8 -2.1 0.0 0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.2 5.4 0.3 0.1 -0.3 -0.6 1.1 -2.3 -1.2 -0.7
Qualifications: None of the above 0.8 1.6 5.6 -1.0 0.5 0.7 1.7 0.3 2.4 0.3 1.6
Financial difficulties in last 2 years 0.5 0.6 2.6 0.4 -0.8 0.6 -0.4 -0.2 -0.2 -1.0 -1.6
Mouth/teeth dental problems 0.1 0.2 0.5 -0.3 0.5 0.4 0.5 -0.7 0.1 0.5 0.2
Heart attack 0.9 1.2 2.3 -1.3 -0.3 1.2 -0.4 1.3 1.4 1.5 0.1
Allergy 0.7 1.6 4.3 -0.9 0.9 0.2 -0.5 1.2 1.8 1.5 2.1
Pain all over the body in last month 0.5 0.5 2.3 0.8 -0.6 0.6 0.3 -0.3 -0.5 -0.1 -1.5
Diabetes (self-reported) 0.7 1.1 2.6 -0.3 1.6 -1.0 1.4 -0.2 1.1 0.3 1.3
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.7 1.5 -0.1 -0.1 1.0 -0.7 -2.0 -0.5 -2.4
Medication: Ramipril 0.3 0.4 1.1 1.0 -0.4 -0.3 -1.0 0.0 0.0 0.4 -1.0
Medication: Simvastatin 0.8 1.2 5.4 0.3 -0.5 0.5 -0.7 0.4 2.3 1.4 0.9
Fluid intelligence score 0.2 0.3 1.0 0.1 0.8 0.5 0.0 0.2 -0.7 -0.5 -1.0
Illnesses of siblings 1.0 1.4 4.6 -0.4 -1.2 -1.4 -1.6 0.4 -2.2 -0.3 -0.0
Neuroticism score 1.6 3.4 9.0 1.8 -0.0 -0.1 -0.5 -0.4 -3.0 -2.4 -2.9
Weight 0.5 2.4 9.7 2.0 0.5 -1.4 1.1 -0.6 -3.1 0.4 -1.4
Impedance of arm (right) 0.9 4.1 10.8 -3.1 0.4 -0.1 1.1 3.3 2.6 -0.3 2.0
Arm fat percentage (right) 0.3 1.2 5.7 1.0 1.0 -1.0 2.4 0.9 -0.3 0.2 0.4
Trunk fat-free mass 0.5 3.0 17.8 1.1 0.6 -1.6 0.1 -0.8 -4.2 0.2 -1.0
Hip circumference 0.4 1.7 5.0 1.7 0.8 -1.2 1.1 -0.1 -2.2 1.4 -0.8
Time employed in main current job 1.3 1.5 6.7 -0.4 1.2 -0.7 0.4 2.6 -0.7 -0.3 1.5
Alcohol intake versus 10 years previously 1.6 2.4 5.0 2.2 -1.4 0.6 1.5 -2.0 1.3 0.8 -1.7
Father’s age at death 0.5 0.7 1.9 -0.5 -1.1 -0.4 -1.4 -0.6 0.4 -1.2 0.3
Worrier / anxious feelings 0.7 1.2 2.9 -0.2 0.4 0.5 -1.2 1.7 -1.4 -1.1 -1.4
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 7.0 1.1 -0.9 -1.5 -0.6 -0.4 -2.6 -2.4 -1.4
Falls in the last year 0.3 0.4 1.2 0.8 -1.1 -0.5 0.8 -0.3 -0.3 0.1 -0.0
Hair/balding pattern: Pattern 3 1.4 2.1 5.7 0.9 2.2 -1.1 -0.1 2.4 -1.0 0.9 1.6
Number of live births 0.3 0.4 1.4 -0.8 -0.3 0.0 -1.0 0.2 0.4 0.3 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 3.6 -0.6 0.3 0.9 1.9 0.7 -0.6 0.5 -0.4
Pulse rate 0.2 0.4 1.1 0.6 -0.9 0.3 0.2 -0.9 -0.4 -0.0 -1.0
Happiness 1.8 2.2 6.6 0.6 -0.7 -0.8 0.3 -1.0 -2.6 -2.5 -1.4
Noisy workplace 0.5 0.6 1.4 0.2 -1.2 0.9 -0.4 0.2 0.2 0.8 -1.2
Qualifications: A levels/AS levels or equivalent 0.5 1.1 4.7 0.3 0.4 -0.3 -0.3 1.6 -2.2 -1.0 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.3 0.2 1.5 1.3 1.4 0.9 0.3 1.5 -0.4
Mouth/teeth dental problems: Dentures 0.7 1.2 4.9 1.4 -0.1 -2.2 -0.5 -0.4 -0.1 -1.0 1.1
Asthma 0.7 1.3 5.8 -0.1 -1.6 0.4 -0.6 -0.8 -0.1 -1.1 -2.4
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.6 5.0 2.0 0.2 0.9 2.2 -2.2 0.4 -1.1 -2.2
Medication: Cholesterol lowering 0.5 0.8 2.9 -0.3 0.2 0.2 -0.6 0.7 1.7 1.3 0.9
Depression (self-reported) 0.6 0.8 2.4 -0.8 0.7 -1.5 0.7 0.4 -1.1 -0.7 0.5
Medication: Lansoprazole 1.5 1.7 6.6 0.1 0.2 -2.6 -0.6 0.5 -2.0 -1.3 0.7
Prospective memory result 0.4 0.5 2.3 0.2 0.1 0.0 0.8 0.5 0.1 1.5 0.7
Lung cancer (father) 0.3 0.3 1.1 0.2 -0.6 -0.4 -0.3 1.0 0.1 -0.1 0.8
Illnesses of mother 1.4 1.7 5.3 -0.2 -1.2 2.3 -0.2 -0.3 1.6 1.7 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.5 -0.7 0.4 0.8 1.6 0.6 -1.0 0.6 -0.9
Pulse wave Arterial Stiffness index 0.1 0.1 0.5 -0.3 -0.5 0.3 -0.1 0.7 0.1 0.4 0.1
Impedance of arm (left) 0.5 2.4 6.2 -2.5 0.0 -0.7 0.2 2.5 1.9 -0.6 1.6
Arm fat mass (right) 0.3 1.4 3.6 1.9 0.7 -1.1 1.6 -0.1 -1.5 0.4 -0.7
Trunk predicted mass 0.5 2.9 17.4 1.1 0.5 -1.7 0.1 -0.8 -4.2 0.2 -0.8
Standing height 0.4 3.6 20.5 0.5 0.3 -2.3 -0.4 0.0 -4.5 -0.9 -1.5
Length of working week for main job 0.9 1.0 4.1 -0.2 0.4 2.0 1.5 0.2 0.0 0.8 -0.7
Exposure to tobacco smoke at home 0.3 0.3 1.2 -0.5 0.3 0.2 1.1 0.4 0.4 0.8 0.5
Breastfed as a baby 1.4 1.7 6.4 0.4 -2.5 -1.5 -1.1 0.5 -0.2 -1.8 0.3
Tense / ‘highly strung’ 0.4 0.7 4.1 -0.1 0.2 -0.1 -0.0 -0.0 -2.0 -1.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.9 0.1 0.6 1.1 -0.6 1.1 -1.0 -0.7 -1.7
Hair/balding pattern: Pattern 4 0.1 0.4 1.5 -1.1 -1.2 0.3 0.0 -0.2 0.1 -0.3 -0.2
Birth weight of first child 1.0 1.8 4.7 -0.9 1.3 0.1 -0.1 2.0 -2.2 1.5 0.7
Peak expiratory flow (PEF) 0.2 0.4 0.8 -0.5 -0.8 -0.7 0.9 0.3 0.1 -0.2 0.7
Pulse wave reflection index 0.5 0.6 1.8 -1.0 0.5 -0.1 -0.8 1.1 0.1 0.6 1.3
Ever highly irritable/argumentative for 2 days 0.8 1.0 4.5 -2.1 0.8 0.1 -1.1 0.5 -0.9 0.3 -0.5
Loud music exposure frequency 1.7 1.9 8.1 -2.9 -0.4 0.9 0.2 1.1 1.3 1.0 1.3
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 5.0 0.4 -0.3 -2.2 -1.5 -0.2 -2.0 -1.1 0.7
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.3 -1.3 0.7 1.7 -0.2 2.1 0.1 1.2 -0.6
Blood clot in the leg (DVT) 0.3 0.3 1.0 -0.2 -1.0 -0.0 -0.6 -0.5 -0.0 -1.0 -0.4
Medication: Paracetamol 1.7 2.7 8.3 -0.8 1.0 2.9 1.5 1.1 0.7 2.1 -1.9
Headache pain in last month 0.6 1.0 1.9 -0.3 0.0 1.4 0.9 1.0 0.9 -1.3 -1.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.5 0.5 -0.7 -0.9 -0.3 -0.9 -2.1 -1.5 -0.7
Glaucoma (self-reported) 0.6 0.7 2.1 -0.8 0.9 0.8 0.7 -0.3 1.4 0.6 0.6
Gout (self-reported) 0.6 0.8 2.1 -0.6 0.1 -1.4 -1.4 0.5 0.3 -0.5 1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 0.8 0.1 -0.3 1.0 -0.6 0.2 0.0 -0.7
Medication: Amlodipine 0.2 0.3 1.1 -0.4 0.4 0.5 0.3 0.3 1.1 0.9 -0.0
Medication: Ventolin 100micrograms inhaler 0.6 0.7 3.2 -1.8 -1.0 -0.5 0.6 0.2 -0.6 0.8 -0.1
Birth weight 0.3 0.7 1.9 -0.9 -1.1 0.0 -1.4 0.9 -0.2 -0.6 0.6
Chronic bronchitis/emphysema (mother) 0.8 1.0 3.1 -0.4 0.5 -1.8 -1.3 -0.5 -1.2 -0.7 0.9
High blood pressure (siblings) 0.5 0.7 2.3 -0.2 0.7 1.5 1.3 -0.5 0.8 0.7 0.2
Forced vital capacity (FVC), Best measure 0.2 0.7 4.1 -0.1 -0.1 -0.1 -0.1 0.8 -2.0 -0.0 -1.0
Body fat percentage 0.4 1.4 4.0 1.9 1.1 -0.6 2.0 0.2 -0.6 0.7 -0.9
Leg fat percentage (right) 0.7 2.4 6.1 1.6 1.4 1.1 2.5 -0.1 0.2 1.9 -1.9
Arm fat-free mass (right) 0.8 4.2 17.1 2.5 -0.1 -1.1 -0.0 -1.9 -4.1 0.2 -2.2
Exposure to tobacco smoke outside home 0.7 0.9 2.3 0.7 -1.5 -1.5 -0.2 -0.4 -1.5 0.5 -0.0
Comparative body size at age 10 0.4 1.2 3.9 0.1 0.4 -1.6 -0.5 -0.4 -2.0 -0.7 1.4
Number of full brothers 0.8 1.0 4.5 0.9 1.3 0.9 2.1 0.2 -0.4 -0.1 -0.3
Worry too long after embarrassment 1.1 1.9 5.0 0.5 1.6 -0.8 -1.8 1.8 -2.2 -0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.4 0.1 1.6 0.7 -0.1 0.5 0.1 0.4 -0.8
Wheeze or whistling in the chest in last year 0.5 0.9 1.7 1.0 -0.8 -1.2 0.6 0.8 -1.3 -1.1 -0.1
Number of children fathered 0.6 0.7 1.3 -1.0 1.2 0.2 0.5 1.0 0.2 0.9 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 1.1 -1.1 0.4 -1.2 0.6 -0.1 0.5 -0.4
Age at first live birth 0.2 0.4 1.0 -0.4 0.6 0.8 1.0 -0.6 0.2 0.5 -0.7
Pulse wave peak to peak time 0.2 0.2 0.6 0.4 0.4 -0.4 0.1 -0.8 -0.4 -0.5 -0.1
Health satisfaction 1.3 1.7 6.5 -0.5 -0.1 -1.1 0.2 0.4 -2.3 -2.5 0.3
Shortness of breath walking on level ground 0.8 0.9 3.8 -0.1 -0.7 -1.2 -0.2 0.2 -0.3 -1.1 2.0
Qualifications: College or University degree 0.5 1.6 4.5 -1.6 -0.7 -1.0 -2.1 0.4 -1.8 -0.9 0.4
Eye problems/disorders: None of the above 0.8 0.9 4.9 0.4 -1.0 0.3 -0.4 -1.0 -0.5 0.1 -2.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.2 -0.7 0.1 1.0 1.5 0.3 0.9 0.4 -0.6
Emphysema/chronic bronchitis 0.4 0.5 1.3 -0.3 -0.7 -0.3 0.2 -1.2 0.7 -1.1 -0.4
Medication for pain relief, constipation, heartburn 1.7 2.9 10.9 0.6 0.6 -3.3 -0.6 0.6 -1.7 -1.5 2.3
Neck or shoulder pain in last month 1.2 1.8 7.3 1.4 -1.7 -1.1 -0.5 -0.2 0.1 -2.7 -0.6
Medication: Blood pressure 1.0 1.7 3.3 -0.7 0.8 1.5 1.0 1.6 1.8 1.8 0.4
Angina (self-reported) 0.9 1.1 3.8 0.2 1.9 0.5 0.3 0.9 -0.5 1.9 0.3
Migraine (self-reported) 0.5 0.7 2.4 -0.7 -0.9 1.1 -0.5 0.2 1.5 0.2 -0.4
Medication: Ibuprofen 1.6 1.9 4.6 1.4 -0.1 1.2 1.4 -1.9 0.8 -0.7 -2.2
Medication: Allopurinol 1.2 1.6 4.0 -1.6 -0.3 -0.9 -1.8 0.2 1.1 -1.0 2.0
Medication: Omeprazole 0.7 0.8 3.2 1.0 0.4 -0.6 0.7 -1.8 0.2 -1.0 0.7
Medication: Seretide 50 evohaler 1.2 1.3 3.1 0.4 1.7 -1.1 -0.1 1.2 -0.7 1.2 1.7
Mean time to correctly identify matches 0.4 0.9 1.3 0.9 1.0 -1.1 -0.4 1.1 -1.1 -0.7 0.8
Heart disease (mother) 1.0 1.2 2.2 1.1 0.4 -1.5 1.2 -1.3 -1.3 -0.9 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.4 5.8 2.4 -1.0 -2.1 -0.1 -2.3 -1.0 -1.4 -0.4
Whole body fat mass 0.4 1.6 4.2 2.1 1.1 -0.9 1.6 0.1 -1.6 0.5 -1.0
Leg fat mass (right) 0.4 1.4 3.3 1.8 0.7 0.1 1.6 -0.4 -0.9 1.0 -1.6
Arm predicted mass (right) 0.8 4.2 17.3 2.4 0.1 -1.2 -0.3 -2.0 -4.2 0.2 -2.1
Pulse rate, automated reading 0.2 0.5 1.8 0.5 -0.1 0.4 -1.3 -0.9 -0.1 0.9 -0.7
Alcohol intake frequency. 0.2 0.4 1.3 -0.1 -0.7 0.5 0.5 -0.8 0.7 1.1 -0.4
Comparative height size at age 10 0.2 1.3 3.3 0.8 0.7 -1.8 1.1 1.1 -1.6 1.0 0.4
Number of full sisters 1.1 1.4 3.5 -0.2 -1.6 0.2 -1.4 -1.9 1.7 0.0 0.1
Suffer from ‘nerves’ 2.4 3.7 8.8 2.3 -1.1 -0.4 -1.3 -1.9 -1.9 -2.2 -3.0
Overall health rating 0.4 0.9 2.3 1.3 -0.6 -0.7 -0.1 -0.0 -1.4 -1.5 -0.7
Chest pain or discomfort 0.7 1.1 4.2 -0.2 -0.7 -1.3 0.2 -1.3 -2.0 -0.7 -0.4
Had major operations 0.3 0.3 1.3 -0.1 -0.7 -1.2 -0.5 0.1 -0.3 0.3 0.4
Age at last live birth 0.5 0.7 1.9 -1.4 -0.0 1.1 1.0 0.3 0.6 0.6 -0.6
Family relationship satisfaction 0.4 0.5 2.3 -0.4 -0.2 0.3 0.5 -1.5 -0.0 -0.7 -0.7
Leg pain on walking 0.3 0.4 0.8 0.0 0.3 -0.6 0.5 -0.9 -0.9 -0.7 0.2
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 9.6 0.7 -0.4 2.8 -0.6 -2.1 1.7 2.4 -3.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.6 1.3 -0.8 0.3 0.6 -0.2 0.1 1.1 -0.8
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 5.0 -1.6 0.8 -0.2 -0.6 0.8 0.8 0.3 2.2
Medication: Aspirin 0.6 0.8 2.1 -1.1 -1.4 0.3 -1.2 0.6 0.2 0.9 0.2
Supplements: Vitamin C 0.8 1.0 2.8 -1.7 0.1 -1.1 0.4 -0.9 -0.0 0.2 1.6
Knee pain experienced in last month 0.8 1.2 2.6 1.3 -1.3 -1.1 0.9 -0.5 -1.3 -1.6 -0.2
Hypertension (Self-reported) 0.3 0.9 3.1 0.8 0.4 0.5 1.7 -0.3 1.7 0.6 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 10.6 0.3 3.2 -0.0 1.0 0.0 -1.0 1.1 1.0
Illnesses of father: Heart disease 1.3 1.8 6.0 0.8 1.7 0.6 1.7 1.1 -0.2 2.5 0.5
Illnesses of siblings: Diabetes 0.4 0.4 1.8 -0.4 -0.3 -0.5 -0.3 -0.8 1.3 0.5 0.4
Smoking status: Previous 1.5 2.3 5.9 1.2 -2.0 -0.5 0.7 -2.3 2.4 -0.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 5.6 1.5 -0.1 -1.0 -0.1 -0.1 -2.4 -0.3 -1.4
Whole body fat-free mass 0.5 2.8 16.4 1.2 0.2 -1.8 -0.1 -0.9 -4.0 -0.2 -0.8
Leg fat-free mass (right) 0.5 2.9 14.8 1.2 0.0 -2.5 -0.2 -0.4 -3.9 -1.0 -0.0
Arm fat percentage (left) 0.3 1.1 4.0 1.2 0.8 -1.5 2.0 0.6 -0.7 -0.0 0.4
Average weekly red wine intake 1.1 1.7 4.2 -0.1 -0.1 -1.4 -1.5 -1.9 -2.0 -0.5 -1.0
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.3 -0.2 0.5 1.0 0.5 0.8 -0.9 0.1
Mood swings 0.9 1.6 5.1 1.6 -0.2 0.2 0.5 -1.1 -1.6 -0.9 -2.3
Loneliness, isolation 1.0 1.3 4.2 1.3 -0.8 -0.4 0.5 -0.1 -1.5 -2.0 -1.2
Long-standing illness, disability or infirmity 0.9 1.4 3.1 1.8 -0.3 -0.6 -0.4 -1.5 -0.4 -1.6 -1.5
Ever had bowel cancer screening 0.8 0.9 3.5 0.7 -0.6 -1.9 -1.1 -0.9 -0.7 -0.7 0.2
Diabetes diagnosed by doctor 0.6 1.0 3.0 -0.2 1.2 -1.1 1.7 -0.2 1.0 0.2 1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.3 1.1 0.9 0.7 1.4 -0.7 -1.0 -1.7 -1.8
Friendships satisfaction 1.1 1.4 5.4 -2.3 1.0 0.3 -0.8 0.7 -1.8 -0.1 -0.1
Qualifications: nursing, teaching 0.9 1.3 4.7 -0.3 1.2 0.6 -0.9 2.2 -0.5 1.7 0.4
Commuting to job workplace: Walk 0.4 0.5 2.4 -1.5 0.9 0.2 -0.2 0.6 0.2 -0.1 0.3
Eye problems/disorders: Cataract 0.7 0.8 2.4 0.3 1.0 -0.4 0.8 1.4 -0.2 -0.1 1.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.2 -0.1 -0.3 0.5 -1.5 0.6 0.6 -0.5 0.1
Medication for cholesterol 0.8 1.3 4.0 0.4 -0.4 -1.3 -1.1 -0.8 -2.0 -1.5 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 4.8 -0.1 0.2 1.8 0.9 -0.4 0.9 1.5 -2.2
Back pain experienced in last month 1.1 1.7 5.2 0.3 -1.5 -0.3 -0.0 -0.8 -1.1 -2.3 -2.0
Mineral and other dietary supplements 0.5 0.6 2.5 -0.7 0.2 -0.2 -0.5 1.6 -0.5 -1.1 0.6
Breast cancer (self-reported) 0.5 0.6 1.5 -0.5 -1.2 0.5 -0.5 1.0 0.3 1.2 0.3
Asthma (self-reported) 0.5 1.1 4.7 -0.1 -1.2 0.3 -0.4 -0.7 -0.0 -1.3 -2.2
Osteoporosis (self-reported) 0.8 1.0 2.8 -0.9 -0.9 0.5 -1.7 -0.3 1.1 -0.6 -1.1
Osteoarthritis (self-reported) 0.4 0.5 1.1 1.0 -1.0 0.3 0.4 -0.6 0.2 -0.8 -0.7
Medication: Aspirin 0.6 0.7 1.6 -1.3 -0.8 0.3 -1.0 1.0 0.4 1.0 0.6
Medication: Gliclazide 1.5 1.7 5.0 -1.0 2.2 -0.7 -0.5 -0.1 1.1 1.5 1.9
Illnesses of father: None of the above (group 1) 0.9 1.1 4.1 -1.3 -0.8 -1.0 -0.9 0.2 -0.4 -2.0 0.1
Smoking status: Current 0.5 0.8 5.3 0.2 2.3 0.0 0.2 -0.5 -0.7 0.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 5.3 0.5 1.5 0.9 1.0 2.3 -0.6 1.5 0.2
Whole body water mass 0.5 3.1 17.1 1.5 0.1 -1.8 -0.2 -0.9 -4.1 -0.3 -0.9
Leg predicted mass (right) 0.5 2.9 14.6 1.2 0.1 -2.4 -0.3 -0.5 -3.8 -1.0 -0.2
Arm fat mass (left) 0.4 1.6 4.7 2.2 0.6 -1.4 1.5 -0.0 -1.7 0.1 -0.5
Number of self-reported non-cancer illnesses 1.0 1.8 6.0 1.2 -2.4 -0.5 0.1 -1.0 0.7 -1.9 -1.3
Average weekly champagne plus white wine intake 1.2 1.7 5.8 -2.4 -0.5 0.5 0.2 1.2 -1.6 -1.7 0.2
Miserableness 0.7 1.2 5.2 1.4 -0.1 0.0 -0.2 0.1 -1.4 -0.4 -2.3
Guilty feelings 1.6 2.5 9.6 1.7 1.2 -0.9 -1.3 0.8 -3.1 -1.4 -0.8
Wears glasses or contact lenses 1.8 2.1 5.5 0.6 1.2 1.5 2.3 1.3 1.4 1.9 -0.2
Ever taken oral contraceptive pill 1.7 1.9 4.2 0.3 -1.6 2.0 0.6 -1.4 1.4 -0.4 -2.0
Hearing aid user 0.2 0.3 1.0 -0.2 -0.1 1.0 0.2 0.1 -0.4 1.0 -0.2
Mother’s age at death 0.8 1.0 3.2 -1.6 -0.1 -0.0 -0.4 0.2 1.3 0.6 1.8
Financial situation satisfaction 0.7 0.9 3.2 0.6 -0.3 -0.4 -0.1 -0.9 -1.8 -1.0 -1.2
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.7 -0.0 -0.5 0.1 1.3 -1.0 -0.1 0.0 -0.1
Commuting to job workplace: Public transport 2.3 2.7 8.2 -2.9 1.1 -1.1 -1.1 1.6 -1.4 -0.6 2.3
Eye problems/disorders: Glaucoma 0.3 0.4 1.4 -0.8 0.3 0.2 0.0 0.4 1.2 -0.3 0.9
Medication: Blood pressure 0.3 0.6 2.1 1.0 1.4 -0.3 0.7 0.2 0.1 1.1 0.3
Pain type(s) experienced in last month: Hip pain 3.3 4.2 11.2 2.1 -1.6 -2.6 -0.6 -1.2 -3.3 -2.4 -1.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.6 0.8 0.4 -0.3 -0.1 -1.2 -0.1 1.6 0.5
High cholesterol (Self-reported) 1.5 2.6 6.7 -1.3 -0.4 1.1 -1.8 0.8 2.3 2.6 1.3
Medication: Bendroflumethiazide 2.1 3.2 10.2 -2.1 2.1 -0.1 1.1 0.6 1.4 1.8 3.2
Medication: Paracetamol 1.4 2.1 4.9 -0.7 1.4 2.2 1.6 1.0 0.1 2.0 -1.3
Medication: Lisinopril 0.6 0.8 2.1 -0.8 1.4 0.7 1.0 0.8 0.7 0.2 0.9
Medication: Atorvastatin 0.7 0.9 2.0 -0.4 0.1 -1.2 -1.4 1.4 -0.5 0.2 1.0
Illnesses of father: High blood pressure 1.6 2.0 9.6 -0.6 -3.1 0.6 1.5 -1.6 0.6 -0.6 -0.5
Alcohol drinker status: Never 0.9 1.0 1.9 1.0 -1.3 -1.3 0.7 0.4 -1.4 -1.2 -0.4
Ever smoked 0.5 0.8 2.4 1.1 1.2 -0.3 0.6 -0.9 1.5 -0.4 0.2
Basal metabolic rate 0.5 2.9 15.3 1.6 0.3 -1.8 0.1 -0.9 -3.9 -0.2 -1.1
Leg fat percentage (left) 0.7 2.4 6.5 2.2 1.5 0.6 2.5 0.0 -0.2 1.5 -1.8
Arm fat-free mass (left) 0.7 3.4 13.7 2.5 0.2 -0.9 -0.1 -1.5 -3.7 0.5 -2.0
Number of operations (self-reported) 0.8 1.2 4.4 0.7 -0.8 -2.1 -1.5 0.3 -0.2 -1.0 0.4
Average weekly beer plus cider intake 1.7 2.4 7.7 0.6 1.4 1.5 2.8 0.9 2.3 0.6 0.9
Irritability 1.2 2.1 8.0 0.9 -1.0 2.3 -0.0 -0.4 0.8 1.0 -2.8
Risk taking 1.3 1.9 5.6 -0.1 -1.8 -1.4 -0.9 -1.7 -0.8 -2.4 -0.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 0.0 0.8 -0.1 -0.7 0.6 -0.4 0.5 1.2
Fractured/broken bones in last 5 years 0.4 0.5 1.1 0.2 1.1 -0.9 -0.4 0.9 -0.4 -0.8 0.6
Age started oral contraceptive pill 0.4 0.5 2.6 0.3 0.5 0.9 -0.1 -0.5 -0.2 1.6 -0.3
Diastolic blood pressure, automated reading 1.0 3.2 11.3 3.4 1.5 1.4 2.1 -0.5 0.2 1.1 -1.9
Ever depressed for a whole week 0.6 0.7 2.1 0.5 0.3 -0.8 -0.4 -1.1 -1.1 -1.5 -0.3
Unable to work because of sickness or disability 0.8 1.1 3.0 1.7 0.3 -1.3 0.7 0.2 -1.4 -1.3 0.2
Commuting to job workplace: Cycle 0.3 0.4 2.1 -0.5 0.1 0.3 -1.5 0.4 0.1 0.2 0.4
Myopia 0.7 0.9 4.7 0.1 0.5 -0.0 -1.1 -0.7 -1.0 0.3 -2.2
Vascular/heart problems diagnosed by doctor 0.7 1.8 5.8 -0.6 -0.8 -1.0 -2.4 0.1 -2.2 -1.2 0.2
Cholesterol lowering medication 0.6 0.8 2.0 0.3 0.0 -0.5 -1.1 -0.0 1.2 1.3 1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.6 1.6 0.8 -1.1 0.7 -1.0 -0.5 -1.0 0.3
Pain experienced in last month 1.5 2.5 6.3 -1.6 1.3 0.8 -0.1 0.5 2.5 1.8 2.3
Supplements: Calcium 0.4 0.4 0.9 0.3 0.4 -0.5 -0.9 -0.7 -0.9 0.8 0.4
Basal cell carcinoma (self-reported) 2.3 2.7 6.6 -1.6 1.1 2.4 0.2 0.8 2.6 2.2 0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.9 -1.2 -0.5 1.1 -0.1 1.2 1.3 1.4 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 -0.4 -0.7 0.2 -1.0 -0.2 -0.2 -0.7 -0.3
Heart disease (siblings) 0.7 0.8 2.9 0.4 1.7 -0.8 0.8 0.0 -0.3 1.2 0.7
Alcohol drinker status: Previous 0.5 0.6 1.4 -0.7 1.1 0.5 0.3 -0.7 1.2 0.2 0.9
Pack years of smoking 1.8 2.6 9.9 0.7 -0.8 -3.1 0.2 -1.0 -1.4 -2.4 0.9
Impedance of whole body 0.3 1.4 4.1 -1.5 0.3 0.9 0.5 1.9 2.0 0.5 -0.1
Leg fat mass (left) 0.4 1.6 4.6 2.1 0.7 -0.2 1.8 -0.3 -1.3 0.8 -1.5
Arm predicted mass (left) 0.6 3.2 14.7 2.2 0.2 -0.9 -0.1 -1.3 -3.8 0.5 -1.9