[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:125,506,061-128,116,643

Best TWAS P=1.9e-15 · Best GWAS P=3.94e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Esophagus Muscularis	C5orf63	0.16	0.18	lasso	9	0.18	2.1e-11	-7.8	8.0	1.9e-15	-0.99	0.02	0.98	TRUE
38	GTEx	Thyroid	CTC-228N24.3	0.31	0.15	enet	32	0.18	4.6e-14	-6.8	7.2	4.0e-13	-0.07	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	C5orf63	0.10	0.12	enet	13	0.12	8.7e-10	-7.7	7.9	2.2e-15	-0.97	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ44606	0.02	0.03	lasso	4	0.02	1.1e-03	-7.7	7.9	3.0e-15	-0.95	0.01	0.96	FALSE
18	GTEx	Colon Sigmoid	C5orf63	0.17	0.23	enet	12	0.23	8.5e-09	-7.8	7.9	3.1e-15	-0.99	0.02	0.98	FALSE
16	GTEx	Cells Transformed fibroblasts	C5orf63	0.17	0.14	lasso	10	0.15	2.7e-11	-7.7	7.9	3.7e-15	-0.95	0.03	0.97	FALSE
29	GTEx	Nerve Tibial	C5orf63	0.21	0.32	lasso	7	0.32	8.9e-23	-7.8	7.8	4.8e-15	-1.00	0.01	0.99	FALSE
27	GTEx	Muscle Skeletal	MARCH3	0.04	0.05	lasso	4	0.05	2.1e-05	-7.8	-7.8	5.0e-15	1.00	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ44606	0.12	0.02	blup	42	0.06	4.5e-03	-7.8	-7.8	5.7e-15	0.90	0.01	0.70	FALSE
8	GTEx	Artery Coronary	C5orf63	0.20	0.14	lasso	5	0.15	7.9e-06	-7.8	-7.7	2.1e-14	0.91	0.03	0.96	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	C5orf63	0.21	0.15	lasso	4	0.16	1.4e-06	-7.1	7.6	2.3e-14	-0.95	0.03	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	C5orf63	0.11	0.07	lasso	4	0.05	9.8e-04	-7.6	7.6	2.5e-14	-0.98	0.04	0.94	FALSE
7	GTEx	Artery Aorta	C5orf63	0.19	0.27	enet	18	0.27	2.1e-15	-7.2	7.6	4.0e-14	-0.98	0.05	0.95	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	MARCH3	0.09	0.08	lasso	2	0.07	4.3e-09	7.3	-7.3	2.3e-13	0.92	0.08	0.92	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	C5orf63	0.09	0.13	bslmm	371	0.13	4.5e-16	-7.6	7.2	6.7e-13	-0.84	0.04	0.96	FALSE
9	GTEx	Artery Tibial	C5orf63	0.21	0.19	lasso	8	0.23	3.9e-18	-7.1	7.1	1.1e-12	-0.91	0.02	0.98	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	C5orf63	0.14	0.01	lasso	7	0.01	7.4e-02	-7.9	7.0	3.0e-12	-0.90	0.03	0.92	FALSE
5	GTEx	Adrenal Gland	C5orf63	0.22	0.05	lasso	8	0.12	3.7e-05	-7.8	7.0	3.1e-12	-0.83	0.03	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C5orf63	0.12	0.12	enet	14	0.15	5.9e-18	-7.6	6.9	6.2e-12	-0.91	0.04	0.96	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ33630	0.10	0.10	lasso	2	0.09	5.3e-09	-6.8	6.8	1.1e-11	0.04	0.00	1.00	FALSE
31	GTEx	Pancreas	CTC-228N24.3	0.14	0.19	lasso	2	0.17	1.1e-07	-6.8	6.8	1.2e-11	0.04	0.00	1.00	FALSE
39	GTEx	Uterus	C5orf63	0.27	0.12	lasso	2	0.00	4.1e-01	-7.0	6.8	1.2e-11	-0.88	0.05	0.40	FALSE
34	GTEx	Skin Sun Exposed Lower leg	C5orf63	0.05	0.06	lasso	3	0.03	8.8e-04	-7.1	6.8	1.3e-11	-0.85	0.03	0.95	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ33630	0.26	0.14	lasso	3	0.13	2.2e-05	-6.8	6.8	1.4e-11	0.04	0.00	1.00	FALSE
40	METSIM	Adipose	CTC-228N24.3	0.17	0.19	lasso	6	0.18	1.9e-26	-6.8	6.7	3.0e-11	0.04	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ33630	0.09	0.08	lasso	4	0.09	4.9e-10	-6.8	6.7	3.0e-11	0.04	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ33630	0.19	0.16	enet	4	0.16	1.2e-17	-6.8	6.6	3.2e-11	0.04	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	FLJ33630	0.38	0.20	lasso	5	0.17	6.5e-06	-6.8	6.6	3.6e-11	0.04	0.00	1.00	FALSE
10	GTEx	Artery Tibial	CTC-228N24.3	0.20	0.16	lasso	7	0.14	3.0e-11	-6.8	6.5	6.6e-11	0.05	0.00	1.00	FALSE
28	GTEx	Muscle Skeletal	CTC-228N24.3	0.25	0.20	lasso	5	0.21	1.6e-20	-6.8	6.5	9.3e-11	0.02	0.00	1.00	FALSE
6	GTEx	Adrenal Gland	CTC-228N24.3	0.34	0.10	lasso	9	0.09	4.2e-04	-6.0	6.4	1.2e-10	0.04	0.04	0.94	FALSE
11	GTEx	Brain Cerebellar Hemisphere	C5orf63	0.21	0.05	lasso	13	0.05	2.5e-02	-7.6	6.4	2.1e-10	-0.85	0.04	0.78	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	CTC-228N24.3	0.15	0.09	lasso	3	0.12	8.0e-15	-6.8	6.3	2.4e-10	0.03	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	CTC-228N24.3	0.24	0.15	enet	16	0.20	3.4e-16	-6.8	6.3	3.8e-10	0.03	0.00	1.00	FALSE
44	YFS	Blood	MARCH3	0.08	0.06	blup	426	0.07	7.8e-23	-7.8	6.3	3.9e-10	-0.75	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ33630	0.05	0.04	enet	14	0.03	2.1e-07	-6.8	6.2	5.1e-10	0.05	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ33630	0.10	0.07	lasso	3	0.08	7.0e-09	-6.1	6.2	5.1e-10	0.04	0.00	1.00	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	CTC-228N24.3	0.24	-0.01	enet	26	0.04	2.2e-02	-3.4	6.2	6.3e-10	0.06	0.04	0.60	FALSE
14	GTEx	Brain Frontal Cortex BA9	C5orf63	0.11	0.00	enet	28	0.00	3.5e-01	-7.8	6.2	6.7e-10	-0.80	0.04	0.75	FALSE
24	GTEx	Heart Atrial Appendage	CTC-228N24.3	0.22	0.07	lasso	5	0.07	4.1e-04	-6.2	6.2	7.3e-10	0.02	0.01	0.98	FALSE
23	GTEx	Heart Atrial Appendage	C5orf63	0.11	0.00	enet	12	0.00	5.5e-01	-4.1	6.2	7.4e-10	-0.79	0.06	0.76	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	CTC-228N24.3	0.29	0.21	lasso	7	0.22	1.7e-12	-6.8	6.1	1.0e-09	0.04	0.01	0.99	FALSE
21	GTEx	Esophagus Mucosa	CTC-228N24.3	0.18	0.14	enet	11	0.14	9.8e-10	-6.8	6.1	1.1e-09	0.06	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ33630	0.07	0.05	lasso	1	0.04	1.3e-05	-6.1	6.1	1.4e-09	0.03	0.01	0.99	FALSE
25	GTEx	Heart Left Ventricle	CTC-228N24.3	0.24	0.15	lasso	7	0.19	1.9e-10	-6.2	6.0	1.7e-09	0.04	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	CTC-228N24.3	0.32	0.18	lasso	10	0.16	1.6e-11	-6.1	6.0	2.0e-09	0.03	0.02	0.98	FALSE
37	GTEx	Testis	CTC-228N24.3	0.30	0.16	lasso	6	0.14	1.1e-06	-6.8	5.8	5.3e-09	0.03	0.00	1.00	FALSE
36	GTEx	Spleen	C5orf63	0.34	-0.01	lasso	5	0.00	3.1e-01	-3.1	5.8	6.8e-09	-0.78	0.04	0.56	FALSE
19	GTEx	Colon Sigmoid	CTC-228N24.3	0.20	0.22	enet	11	0.23	1.1e-08	-6.1	5.6	1.9e-08	0.04	0.02	0.98	FALSE
41	NTR	Blood	FLJ44606	0.02	0.00	blup	359	0.01	8.4e-04	-2.8	-5.6	1.9e-08	0.68	0.12	0.55	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CTC-228N24.3	0.25	0.00	lasso	6	0.05	2.2e-02	2.5	5.6	2.4e-08	-0.13	0.04	0.51	FALSE
13	GTEx	Brain Cerebellum	CTC-228N24.3	0.31	0.04	lasso	5	0.12	2.9e-04	-6.8	5.6	2.4e-08	0.04	0.01	0.96	FALSE
26	GTEx	Lung	CTC-228N24.3	0.18	0.14	enet	16	0.14	3.2e-11	-6.8	5.5	3.6e-08	0.04	0.00	1.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	CTC-228N24.3	0.29	0.17	enet	12	0.22	4.3e-18	-6.2	5.5	4.6e-08	0.05	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	CTC-228N24.3	0.24	0.16	enet	26	0.16	8.6e-12	-6.8	5.4	8.1e-08	0.04	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ33630	0.08	0.03	lasso	2	0.04	5.7e-03	-6.1	5.1	3.1e-07	0.07	0.01	0.88	FALSE