[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr5:130,451,873-133,140,038

Best TWAS P=6.16e-30 · Best GWAS P=1.04e-37 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ACSL6 0.13 0.07 enet 47 0.08 1.9e-10 -5.6 -5.2 1.7e-07 0.27 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex PDLIM4 0.11 0.18 lasso 5 0.18 8.0e-21 -6.2 -6.3 2.3e-10 0.33 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous SLC22A5 0.05 0.04 lasso 4 0.04 4.2e-04 8.2 -7.9 3.9e-15 0.47 0.35 0.46 FALSE
4 GTEx Artery Aorta P4HA2 0.12 0.14 lasso 2 0.11 1.2e-06 7.3 7.3 2.5e-13 -0.46 0.96 0.01 FALSE
5 GTEx Artery Aorta P4HA2-AS1 0.08 0.03 lasso 3 0.01 6.6e-02 6.8 6.6 4.9e-11 -0.40 0.41 0.17 FALSE
6 GTEx Artery Tibial P4HA2 0.12 0.15 lasso 6 0.14 3.2e-11 6.8 6.6 4.3e-11 -0.39 1.00 0.00 FALSE
7 GTEx Artery Tibial SLC22A5 0.18 0.12 enet 8 0.12 2.5e-09 8.2 -10.9 7.7e-28 0.69 0.89 0.11 FALSE
8 GTEx Artery Tibial P4HA2-AS1 0.10 0.09 lasso 4 0.11 1.0e-08 6.7 7.7 1.7e-14 -0.41 1.00 0.00 FALSE
9 GTEx Brain Caudate basal ganglia SLC22A5 0.19 0.03 enet 17 0.12 2.7e-04 -7.2 -5.3 8.9e-08 0.35 0.07 0.29 FALSE
10 GTEx Brain Putamen basal ganglia SLC22A5 0.27 0.05 lasso 8 0.07 8.8e-03 3.5 -5.5 3.6e-08 0.24 0.25 0.04 FALSE
11 GTEx Cells EBV-transformed lymphocytes SLC22A5 0.37 0.05 lasso 13 0.10 2.8e-04 8.6 -5.4 5.8e-08 0.35 0.49 0.03 FALSE
12 GTEx Cells Transformed fibroblasts PDLIM4 0.08 0.09 lasso 1 0.07 6.4e-06 -6.3 -6.3 2.3e-10 0.32 0.84 0.01 FALSE
13 GTEx Cells Transformed fibroblasts SLC22A5 0.32 0.28 lasso 7 0.35 1.6e-27 -9.3 -10.3 7.0e-25 0.63 1.00 0.00 FALSE
14 GTEx Colon Transverse SLC22A5 0.12 0.07 enet 8 0.07 2.5e-04 8.6 -8.7 3.4e-18 0.54 0.40 0.30 FALSE
15 GTEx Esophagus Gastroesophageal Junction SEPT8 0.22 0.08 lasso 12 0.10 2.2e-04 -6.3 6.5 6.9e-11 -0.26 0.66 0.03 FALSE
16 GTEx Esophagus Gastroesophageal Junction UQCRQ 0.21 0.01 enet 30 0.04 2.0e-02 -8.1 -11.2 6.9e-29 0.61 0.02 0.81 TRUE
17 GTEx Esophagus Mucosa P4HA2 0.23 0.10 lasso 6 0.14 6.1e-10 7.3 6.7 2.3e-11 -0.40 1.00 0.00 FALSE
18 GTEx Esophagus Mucosa SLC22A5 0.16 0.16 enet 8 0.16 6.3e-11 8.6 -7.9 2.0e-15 0.48 1.00 0.00 FALSE
19 GTEx Esophagus Mucosa P4HA2-AS1 0.09 0.06 lasso 6 0.08 5.4e-06 7.3 6.8 7.5e-12 -0.42 0.94 0.00 FALSE
20 GTEx Lung SLC22A5 0.10 0.15 enet 11 0.13 3.4e-10 8.6 -7.8 9.6e-15 0.47 1.00 0.00 FALSE
21 GTEx Muscle Skeletal HSPA4 0.13 0.09 enet 22 0.09 1.5e-09 -7.5 -5.6 2.6e-08 0.15 0.07 0.93 TRUE
22 GTEx Muscle Skeletal MIR3936 0.04 0.01 lasso 4 0.00 9.9e-02 -6.3 7.7 1.4e-14 -0.41 0.24 0.04 FALSE
23 GTEx Nerve Tibial HSPA4 0.15 0.07 lasso 3 0.05 1.0e-04 -7.7 -8.0 1.0e-15 0.13 0.03 0.96 TRUE
24 GTEx Nerve Tibial SLC22A5 0.17 0.11 lasso 9 0.09 5.5e-07 -7.2 -9.1 7.7e-20 0.55 0.74 0.22 FALSE
25 GTEx Ovary PDLIM4 0.25 0.22 enet 10 0.05 2.1e-02 -4.6 6.0 1.7e-09 -0.31 0.42 0.05 FALSE
26 GTEx Pituitary AC034220.3 0.25 0.22 lasso 12 0.18 3.1e-05 -6.5 5.7 1.3e-08 -0.20 0.72 0.02 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic PDLIM4 0.13 0.08 lasso 2 0.06 2.6e-04 8.6 -8.6 6.5e-18 0.47 0.28 0.52 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic SLC22A4 0.13 0.00 lasso 4 0.01 7.1e-02 -8.9 -6.5 7.1e-11 0.38 0.13 0.22 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic SLC22A5 0.13 0.05 lasso 8 0.05 8.3e-04 -3.9 -5.5 4.5e-08 0.24 0.98 0.00 FALSE
30 GTEx Skin Sun Exposed Lower leg PDLIM4 0.09 0.08 lasso 8 0.09 1.0e-07 7.3 -8.4 4.6e-17 0.52 1.00 0.00 FALSE
31 GTEx Skin Sun Exposed Lower leg SLC22A5 0.25 0.21 lasso 3 0.20 1.4e-16 8.2 -8.0 1.4e-15 0.45 1.00 0.00 FALSE
32 GTEx Spleen SLC22A5 0.26 0.28 lasso 4 0.28 6.6e-08 8.6 7.0 2.3e-12 -0.40 0.22 0.44 FALSE
33 GTEx Stomach SLC22A5 0.09 0.04 lasso 4 0.01 9.0e-02 -10.8 -9.8 1.3e-22 0.53 0.11 0.34 FALSE
34 GTEx Stomach AC034220.3 0.17 0.15 enet 21 0.16 4.2e-08 -6.4 5.7 1.1e-08 -0.23 1.00 0.00 FALSE
35 GTEx Testis P4HA2 0.14 0.13 lasso 5 0.11 1.4e-05 7.3 8.5 1.5e-17 -0.52 0.90 0.05 FALSE
36 GTEx Testis HSPA4 0.13 0.13 lasso 2 0.12 9.1e-06 -7.6 -7.6 3.2e-14 0.11 0.05 0.94 FALSE
37 GTEx Thyroid P4HA2 0.08 0.07 enet 9 0.06 3.5e-05 6.8 6.0 2.6e-09 -0.41 0.79 0.02 FALSE
38 GTEx Thyroid PDLIM4 0.05 0.02 enet 5 0.01 3.1e-02 3.1 -5.2 2.5e-07 0.30 0.40 0.14 FALSE
39 GTEx Thyroid SLC22A4 0.06 0.02 lasso 4 0.02 2.3e-02 -6.4 5.6 1.7e-08 -0.18 0.39 0.09 FALSE
40 GTEx Thyroid SLC22A5 0.17 0.07 lasso 5 0.13 4.8e-10 -7.2 -10.0 1.5e-23 0.61 0.91 0.06 FALSE
41 GTEx Thyroid AC004041.2 0.11 0.00 enet 46 0.00 2.6e-01 -7.2 -8.8 8.8e-19 0.43 0.09 0.27 TRUE
42 GTEx Thyroid P4HA2-AS1 0.08 0.06 enet 14 0.05 1.6e-04 6.8 6.8 1.1e-11 -0.46 0.72 0.03 FALSE
43 GTEx Whole Blood SLC22A4 0.07 0.05 enet 16 0.05 4.6e-05 -9.3 -10.0 1.9e-23 0.64 0.38 0.38 FALSE
44 GTEx Whole Blood SLC22A5 0.09 0.12 lasso 2 0.10 1.7e-09 8.6 -8.6 6.8e-18 0.51 1.00 0.00 FALSE
45 GTEx Whole Blood AC034220.3 0.08 0.05 enet 31 0.06 4.0e-06 8.2 -9.4 3.9e-21 0.59 0.94 0.02 FALSE
46 GTEx Whole Blood AC116366.6 0.05 0.04 lasso 17 0.03 5.7e-04 -5.1 5.6 2.7e-08 -0.33 0.53 0.07 FALSE
47 METSIM Adipose P4HA2 0.09 0.08 lasso 12 0.09 2.4e-13 6.7 5.4 6.8e-08 -0.27 1.00 0.00 FALSE
48 METSIM Adipose SLC22A4 0.05 0.02 lasso 3 0.03 8.4e-06 4.3 -5.7 1.2e-08 0.19 0.95 0.00 FALSE
49 METSIM Adipose SLC22A5 0.05 0.08 lasso 1 0.08 1.0e-11 8.6 -8.6 7.4e-18 0.50 1.00 0.00 FALSE
50 NTR Blood C5orf56 0.01 0.01 blup 439 0.01 1.7e-03 -11.9 -10.3 6.7e-25 0.81 0.02 0.94 FALSE
51 NTR Blood IRF1 0.03 0.02 blup 424 0.01 5.7e-05 -5.1 7.8 6.8e-15 -0.47 1.00 0.00 FALSE
52 NTR Blood SLC22A5 0.02 0.01 lasso 5 0.02 2.3e-06 8.3 -8.2 2.5e-16 0.45 0.42 0.43 FALSE
53 ROSMAP Brain Pre-frontal Cortex PDLIM4 0.25 0.27 lasso 4 0.26 2.7e-33 -6.3 -5.9 4.3e-09 0.31 1.00 0.00 TRUE
54 ROSMAP Brain Pre-frontal Cortex SLC22A5 0.09 0.03 lasso 7 0.08 1.7e-10 -7.2 -7.4 1.1e-13 0.45 1.00 0.00 FALSE
55 YFS Blood SLC22A4 0.10 0.12 enet 47 0.14 5.1e-42 -3.9 -7.5 6.0e-14 0.26 1.00 0.00 FALSE
56 YFS Blood SLC22A5 0.38 0.36 bslmm 430 0.37 3.0e-128 8.6 -8.1 7.9e-16 0.52 1.00 0.00 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma HSPA4 0.03 0.02 blup 50 0.02 5.8e-05 -7.9 7.7 1.7e-14 -0.10 0.01 0.99 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma P4HA2 0.03 0.02 blup 47 0.03 3.1e-06 6.7 6.5 9.9e-11 -0.34 0.42 0.47 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma PDLIM4 0.05 0.05 lasso 4 0.05 9.0e-11 -6.3 -6.7 2.1e-11 0.35 0.37 0.63 FALSE
60 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A4 0.05 0.01 enet 7 0.02 1.6e-05 8.6 -7.5 7.1e-14 0.32 0.30 0.42 FALSE
61 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A5 0.05 0.07 enet 11 0.09 5.3e-17 -6.4 -7.5 7.4e-14 0.32 1.00 0.00 TRUE
62 The Cancer Genome Atlas Breast Invasive Carcinoma ZCCHC10 0.03 0.02 blup 30 0.02 1.3e-05 -7.9 7.5 5.3e-14 -0.07 0.01 0.99 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma PDLIM4 0.14 0.04 enet 9 0.09 6.8e-06 -4.6 -7.2 5.4e-13 0.39 0.07 0.89 TRUE
64 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A5 0.08 0.04 blup 92 0.07 1.2e-04 -9.3 -10.1 7.0e-24 0.51 0.21 0.42 FALSE
65 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A4 0.02 0.02 lasso 1 0.02 3.0e-03 -6.3 -6.3 2.6e-10 0.24 0.12 0.55 FALSE
66 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A5 0.06 0.05 blup 93 0.08 1.2e-09 -4.0 -7.6 4.2e-14 0.32 1.00 0.00 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM4 0.09 0.02 lasso 6 0.05 4.5e-06 -5.9 -5.9 4.5e-09 0.40 0.09 0.84 FALSE
68 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC22A4 0.04 0.03 blup 108 0.01 7.1e-02 -6.4 -6.9 6.1e-12 0.29 0.10 0.30 FALSE
69 The Cancer Genome Atlas Brain Lower Grade Glioma HSPA4 0.09 0.01 blup 50 0.05 4.1e-06 -1.7 -6.0 1.8e-09 0.08 0.02 0.83 TRUE
70 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PDLIM4 0.08 0.03 blup 67 0.05 2.4e-03 -6.5 -7.1 1.6e-12 0.31 0.02 0.63 FALSE
71 The Cancer Genome Atlas Lung Adenocarcinoma SLC22A5 0.06 0.03 lasso 4 0.02 9.3e-04 -9.3 -10.4 4.0e-25 0.66 0.17 0.24 FALSE
72 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A4 0.04 0.01 blup 111 0.03 3.0e-04 -6.0 -9.9 4.7e-23 0.47 0.03 0.86 FALSE
73 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A5 0.05 0.03 blup 93 0.05 1.9e-06 -6.4 -7.7 2.0e-14 0.34 0.98 0.00 TRUE
74 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SLC22A5 0.12 0.04 blup 92 0.07 2.2e-05 -9.3 -11.4 6.2e-30 0.63 0.04 0.84 TRUE
75 The Cancer Genome Atlas Prostate Adenocarcinoma PDLIM4 0.32 0.36 enet 13 0.37 3.8e-40 -5.9 -6.4 1.8e-10 0.33 1.00 0.00 FALSE
76 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A4 0.09 0.07 blup 108 0.09 3.0e-09 -3.9 -7.6 2.8e-14 0.36 0.95 0.05 FALSE
77 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A5 0.12 0.05 lasso 4 0.08 1.8e-08 -8.5 -8.8 1.3e-18 0.45 0.94 0.02 FALSE
78 The Cancer Genome Atlas Rectum Adenocarcinoma SLC22A5 0.27 0.21 lasso 12 0.24 2.0e-06 -6.5 -5.7 9.7e-09 0.17 0.62 0.06 FALSE
79 The Cancer Genome Atlas Stomach Adenocarcinoma SLC22A5 0.05 0.01 blup 92 0.02 1.1e-02 -8.2 -10.6 3.4e-26 0.57 0.08 0.22 FALSE
80 The Cancer Genome Atlas Thyroid Carcinoma C5orf56 0.06 0.04 blup 98 0.03 1.3e-03 -5.3 6.0 2.1e-09 -0.37 0.88 0.01 FALSE
81 The Cancer Genome Atlas Thyroid Carcinoma IRF1 0.05 0.02 blup 83 0.03 1.5e-03 8.6 9.9 2.7e-23 -0.51 0.05 0.22 FALSE
82 The Cancer Genome Atlas Thyroid Carcinoma P4HA2 0.21 0.35 enet 10 0.35 4.7e-35 6.7 6.9 4.7e-12 -0.43 1.00 0.00 FALSE
83 The Cancer Genome Atlas Thyroid Carcinoma SLC22A5 0.03 0.02 lasso 1 0.01 2.6e-02 -9.3 -9.3 9.0e-21 0.61 0.03 0.43 FALSE