[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:130,451,873-133,140,038

Best TWAS P=6.16e-30 · Best GWAS P=1.04e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-9.3	-11.4	6.2e-30	0.63	0.04	0.84	TRUE
16	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	-8.1	-11.2	6.9e-29	0.61	0.02	0.81	TRUE
41	GTEx	Thyroid	AC004041.2	0.11	0.00	enet	46	0.00	2.6e-01	-7.2	-8.8	8.8e-19	0.43	0.09	0.27	TRUE
23	GTEx	Nerve Tibial	HSPA4	0.15	0.07	lasso	3	0.05	1.0e-04	-7.7	-8.0	1.0e-15	0.13	0.03	0.96	TRUE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-6.4	-7.7	2.0e-14	0.34	0.98	0.00	TRUE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-6.4	-7.5	7.4e-14	0.32	1.00	0.00	TRUE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-4.6	-7.2	5.4e-13	0.39	0.07	0.89	TRUE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSPA4	0.09	0.01	blup	50	0.05	4.1e-06	-1.7	-6.0	1.8e-09	0.08	0.02	0.83	TRUE
53	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-6.3	-5.9	4.3e-09	0.31	1.00	0.00	TRUE
21	GTEx	Muscle Skeletal	HSPA4	0.13	0.09	enet	22	0.09	1.5e-09	-7.5	-5.6	2.6e-08	0.15	0.07	0.93	TRUE
7	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	8.2	-10.9	7.7e-28	0.69	0.89	0.11	FALSE
79	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-8.2	-10.6	3.4e-26	0.57	0.08	0.22	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-9.3	-10.4	4.0e-25	0.66	0.17	0.24	FALSE
50	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	-11.9	-10.3	6.7e-25	0.81	0.02	0.94	FALSE
13	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-9.3	-10.3	7.0e-25	0.63	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-9.3	-10.1	7.0e-24	0.51	0.21	0.42	FALSE
40	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-7.2	-10.0	1.5e-23	0.61	0.91	0.06	FALSE
43	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-9.3	-10.0	1.9e-23	0.64	0.38	0.38	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	8.6	9.9	2.7e-23	-0.51	0.05	0.22	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-6.0	-9.9	4.7e-23	0.47	0.03	0.86	FALSE
33	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-10.8	-9.8	1.3e-22	0.53	0.11	0.34	FALSE
45	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	8.2	-9.4	3.9e-21	0.59	0.94	0.02	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-9.3	-9.3	9.0e-21	0.61	0.03	0.43	FALSE
24	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	-7.2	-9.1	7.7e-20	0.55	0.74	0.22	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-8.5	-8.8	1.3e-18	0.45	0.94	0.02	FALSE
14	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	8.6	-8.7	3.4e-18	0.54	0.40	0.30	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	8.6	-8.6	6.5e-18	0.47	0.28	0.52	FALSE
44	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	8.6	-8.6	6.8e-18	0.51	1.00	0.00	FALSE
49	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	8.6	-8.6	7.4e-18	0.50	1.00	0.00	FALSE
35	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	7.3	8.5	1.5e-17	-0.52	0.90	0.05	FALSE
30	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	7.3	-8.4	4.6e-17	0.52	1.00	0.00	FALSE
52	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	8.3	-8.2	2.5e-16	0.45	0.42	0.43	FALSE
56	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	8.6	-8.1	7.9e-16	0.52	1.00	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	8.2	-8.0	1.4e-15	0.45	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	8.6	-7.9	2.0e-15	0.48	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	8.2	-7.9	3.9e-15	0.47	0.35	0.46	FALSE
51	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-5.1	7.8	6.8e-15	-0.47	1.00	0.00	FALSE
20	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	8.6	-7.8	9.6e-15	0.47	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-6.3	7.7	1.4e-14	-0.41	0.24	0.04	FALSE
8	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	6.7	7.7	1.7e-14	-0.41	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSPA4	0.03	0.02	blup	50	0.02	5.8e-05	-7.9	7.7	1.7e-14	-0.10	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-3.9	-7.6	2.8e-14	0.36	0.95	0.05	FALSE
36	GTEx	Testis	HSPA4	0.13	0.13	lasso	2	0.12	9.1e-06	-7.6	-7.6	3.2e-14	0.11	0.05	0.94	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-4.0	-7.6	4.2e-14	0.32	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC10	0.03	0.02	blup	30	0.02	1.3e-05	-7.9	7.5	5.3e-14	-0.07	0.01	0.99	FALSE
55	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-3.9	-7.5	6.0e-14	0.26	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	8.6	-7.5	7.1e-14	0.32	0.30	0.42	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	SLC22A5	0.09	0.03	lasso	7	0.08	1.7e-10	-7.2	-7.4	1.1e-13	0.45	1.00	0.00	FALSE
4	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	7.3	7.3	2.5e-13	-0.46	0.96	0.01	FALSE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-6.5	-7.1	1.6e-12	0.31	0.02	0.63	FALSE
32	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	8.6	7.0	2.3e-12	-0.40	0.22	0.44	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	6.7	6.9	4.7e-12	-0.43	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-6.4	-6.9	6.1e-12	0.29	0.10	0.30	FALSE
19	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	7.3	6.8	7.5e-12	-0.42	0.94	0.00	FALSE
42	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	6.8	6.8	1.1e-11	-0.46	0.72	0.03	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-6.3	-6.7	2.1e-11	0.35	0.37	0.63	FALSE
17	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	7.3	6.7	2.3e-11	-0.40	1.00	0.00	FALSE
6	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	6.8	6.6	4.3e-11	-0.39	1.00	0.00	FALSE
5	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	6.8	6.6	4.9e-11	-0.40	0.41	0.17	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-6.3	6.5	6.9e-11	-0.26	0.66	0.03	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-8.9	-6.5	7.1e-11	0.38	0.13	0.22	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	6.7	6.5	9.9e-11	-0.34	0.42	0.47	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-5.9	-6.4	1.8e-10	0.33	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-6.2	-6.3	2.3e-10	0.33	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-6.3	-6.3	2.3e-10	0.32	0.84	0.01	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-6.3	-6.3	2.6e-10	0.24	0.12	0.55	FALSE
25	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-4.6	6.0	1.7e-09	-0.31	0.42	0.05	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-5.3	6.0	2.1e-09	-0.37	0.88	0.01	FALSE
37	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	6.8	6.0	2.6e-09	-0.41	0.79	0.02	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-5.9	-5.9	4.5e-09	0.40	0.09	0.84	FALSE
78	The Cancer Genome Atlas	Rectum Adenocarcinoma	SLC22A5	0.27	0.21	lasso	12	0.24	2.0e-06	-6.5	-5.7	9.7e-09	0.17	0.62	0.06	FALSE
34	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-6.4	5.7	1.1e-08	-0.23	1.00	0.00	FALSE
48	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	4.3	-5.7	1.2e-08	0.19	0.95	0.00	FALSE
26	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-6.5	5.7	1.3e-08	-0.20	0.72	0.02	FALSE
39	GTEx	Thyroid	SLC22A4	0.06	0.02	lasso	4	0.02	2.3e-02	-6.4	5.6	1.7e-08	-0.18	0.39	0.09	FALSE
46	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-5.1	5.6	2.7e-08	-0.33	0.53	0.07	FALSE
10	GTEx	Brain Putamen basal ganglia	SLC22A5	0.27	0.05	lasso	8	0.07	8.8e-03	3.5	-5.5	3.6e-08	0.24	0.25	0.04	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-3.9	-5.5	4.5e-08	0.24	0.98	0.00	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	8.6	-5.4	5.8e-08	0.35	0.49	0.03	FALSE
47	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	6.7	5.4	6.8e-08	-0.27	1.00	0.00	FALSE
9	GTEx	Brain Caudate basal ganglia	SLC22A5	0.19	0.03	enet	17	0.12	2.7e-04	-7.2	-5.3	8.9e-08	0.35	0.07	0.29	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACSL6	0.13	0.07	enet	47	0.08	1.9e-10	-5.6	-5.2	1.7e-07	0.27	1.00	0.00	FALSE
38	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	3.1	-5.2	2.5e-07	0.30	0.40	0.14	FALSE